TYS

$45 Find Cheap Flights from Florida Keys to Knoxville - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Knoxville departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Florida Keys to Knoxville

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Florida Keys to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Florida Keys to Knoxville

Fri, Jul 31 - Mon, Aug 3
Allegiant Air Logo
10:31 am - 12:46 pm
EYW
-
TYS
2h 15mnonstop
Allegiant Air Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
$73Allegiant Air
Fri, Jul 31 - Mon, Aug 3
Allegiant Air Logo
3:27 pm - 9:15 pm
EYW
-
TYS
5h 48m
1 stop
Allegiant Air Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
$134Allegiant Air
Thu, Jul 30 - Mon, Aug 3
Multiple Airlines Logo
3:39 pm - 4:42 pm
MIA
-
TYS
25h 03m
1 stop
Multiple Airlines Logo
12:53 pm - 10:19 pm
TYS
-
MIA
9h 26m
1 stop
$201Multiple Airlines
Thu, Jul 30 - Mon, Aug 3
Multiple Airlines Logo
3:39 pm - 4:42 pm
MIA
-
TYS
25h 03m
1 stop
Multiple Airlines Logo
12:53 pm - 10:19 pm
TYS
-
MIA
9h 26m
1 stop
$203Multiple Airlines
Thu, Jul 9 - Thu, Jul 16
Multiple Airlines Logo
7:53 pm - 11:19 pm
EYW
-
TYS
27h 26m
1 stop
Multiple Airlines Logo
3:53 pm - 2:37 pm
TYS
-
EYW
22h 44m
1 stop
$220Multiple Airlines
Fri, Jul 31 - Mon, Aug 3
Allegiant Air Logo
3:27 pm - 9:15 pm
EYW
-
TYS
5h 48m
1 stop
Allegiant Air Logo
8:30 am - 3:51 pm
TYS
-
EYW
7h 21m
1 stop
$223Allegiant Air
Wed, Jul 29 - Wed, Aug 5
American Airlines Logo
9:45 pm - 11:59 pm
MIA
-
TYS
2h 14mnonstop
American Airlines Logo
6:00 am - 8:12 am
TYS
-
MIA
2h 12mnonstop
$229American Airlines
Fri, Jul 31 - Mon, Aug 3
Multiple Airlines Logo
10:31 am - 12:46 pm
EYW
-
TYS
2h 15mnonstop
Multiple Airlines Logo
12:40 pm - 12:34 pm
TYS
-
EYW
23h 54m
3 stops
$229Multiple Airlines
Tue, Jul 14 - Tue, Jul 21
American Airlines Logo
9:45 pm - 11:59 pm
MIA
-
TYS
2h 14mnonstop
American Airlines Logo
6:00 am - 8:12 am
TYS
-
MIA
2h 12mnonstop
$231American Airlines
Wed, Jul 29 - Wed, Aug 5
Delta Logo
8:20 am - 2:48 pm
MIA
-
TYS
6h 28m
1 stop
Delta Logo
5:40 am - 11:00 am
TYS
-
MIA
5h 20m
1 stop
$249Delta
Useful Info

Good to know

Low seasonJanuary
Cheapest flight$45
Best time to beat the crowds but there is an average 7% increase in price.
Most popular time to fly and prices are also 1% lower on average.
Flight from Key West to Knoxville

FAQs for booking flights from Florida Keys to Knoxville

  • How does KAYAK find such low prices on flights from Florida Keys to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Florida Keys to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Florida Keys to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Florida Keys to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Florida Keys with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Florida Keys to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Florida Keys to Knoxville

 
Need help choosing which airline to fly with from Florida Keys to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8405 reviews
7.8Comfort
7.8Entertainment
8.5Crew
7.2Food
8.1Boarding
Airline reviews

Five hour delays every hour, I wish it were all at once

2.0 MediocreAnonymous, Jun 2026
MCO - LGA
Read more Delta reviews

Five hour delays every hour, I wish it were all at once

Should never have had to go to Detroit from Orlando back to Tennessee!

Got rerouted from a straight flight from Orlando to Atlanta to Knoxville to a flight from Orlando to Detroit to Knoxville! Seriously!! Flight delay out of Detroit! Long day for what should have been a pretty easy travel day!

Left /arrived on time. Decent seat space. Like the wifi/plugs and entertainment. Windows and tray table were kinda gross. Attendants didn't start snack service til 40mins before landing. Two rows before us, captain came on to say there's turbulence and recalled staff to seats. So, no drink/snack. Later, attendants didn't stop to see if we had trash nor even look our way. Felt invisible! Almost all pilot announcements were not only unintelligible, but so quiet. We had no idea what she said.

Gate agent was unhelpful for handicapped boarding. Flight attendant seemed untrained.

Clean planes and not take my comfort class seat away.

Weather caused a long delay, but the efficiency and updates from the pilot were helpful. We were able to make our connection fortunately.

Planes were clean, no water or snacks on either flight.

Aside from a completely packed plane, I really have no complaints.

Much better than Latam, the worse airline company ever. I hope I don't have the need to fly Latam ever in my life again.

Seats were very uncomfortable and being charged for snacks and water.........

Allegiant actually impressed me, original inbound flight from PBG was so late they gave us a bird inbound from Des Moines and only left 1h late and gained 40 minutes back in the air. Comfortable flight with no frills but no complaints.

Flight was delayed. Crew was good but hot coffee was not available.

Great. No choice for n/a. No food or entertainment options

No food is available without purchasing it and there is no in-flight entertainment. Both of these are OK because we got an inexpensive flight from Allegiant and, otherwise, our experience was excellent.

just had water and there was plenty of leg & seat room. But then i don't weight 220#s!!

Not totally their fault- screaming kids that had zero parent intervention.

It was cold on the flight. The crew was very pleasant. I didn't order any food. We were delayed due to Captain waiting on maintenance log. He kept us informed though. The flight itself was smooth. I would definitely fly with Allegiant again!

I had a fantastic experience with Allegiant. I had wheelchair assistance and they helped me find my luggage and brought me to my car. Even loaded my luggage. Wonderful service!! Thank you Allegiant!

Superb. Staff great. Great flight. As with other airlines, seating too tight and restrictive.

Trash. Sat on the runway for 40 mins…missed connecting flight because of it now I’m stuck. Thanks…a whole fkn lot.

Little time between flight from Dallas to flight to Gainesville. We chose this one, 43 minutes between, because the price for a connection with at least an hour between, was so much higher. Had to ask passengers on the Dallas flight to please allow us to deplane ahead of them. The economy passengers allowed this. We had to walk very fast to the next gate, 35 gates away. Thankfully all in the same terminal. Getting to the small Gainesville plane was a little confusing as you enter an area that is boarding many small planes at the same time. We stood in the wrong line for about 15 seconds before realizing it was not our Gainesville flight. Since I had boarded at this gate in the past, I knew to check the signs carefully so we weren’t lost. The first class seat experience was wonderful. I really enjoyed the upgrade. We were offered an alcohol drink as soon as we sat down. I got something different but it was a great gesture especially since we really had to hurry to make the flight. We had packed expecting we might miss this connection, but made it. Our luggage didn’t miss the flight. American Airlines delivered our bags to our home the next day. That was very convenient!

It was what i expected. I like the movies you can access from your phone. It would be nice if there was a gluten free snack offered. But I did bring my own snack knowing there would not be a gluten free option

There were flight delays making our flight arrive at our destination after midnight didn’t seem to have enough crew or airplanes for the flights laid over in Dallas should’ve had plenty of time to make it to our next flight only made it because that flight was also delayed because our plane wasn’t even at the airport yet overall have not had a good experience on American

Requested early boarding to disinfect seat, tray table, etc. before general boarding. Instructed to board after wheelchair passengers. Waited on jet bridge behind 12 wheelchair passengers. Stopped immediately after entering plane to wait for gate agent in rear of plane cleaning a seat that was wet, got to my row and found both seats adjacent to mine already occupied, with the lack of room making it impossible for me to clean my own space and defeating the purpose of my boarding early. Cleaned the armrests and tray table as best I could.

We had several flights and they were all on-time and flawless

Flying in the United States with the major airlines has become so underwhelming. A 2-3hr flight in most other parts of the world with the major carriers of the area comes with newer, CLEANER aircraft and significantly better in flight service in terms of both staff attitude and a actual meal service.

The seats need better cushioning for a nearly 5-hour flight, it was a bit uncomfortable. I'm glad American has free wi-fi but there were was a bout 30 minutes in the middle of the flight when there was no connection which was frustrating.

My original flight got delayed day of so I had to rebook it from one layover to two layovers. The flight also left earlier which was a slight inconvenience but manageable. Then my first connection flight got delayed 3 separate times for a total of 2 hours delayed, causing me to miss my second connection flight back to Santa Barbara. Now, because of this missed flight, I am missing my college classes that I pay for.

Flight: Started on time. Comfortable flight. Arrived on time. Crew: Very cordial and helpful. Drinks and snack was served with a smile. Overall enjoyed the trip. Regards, Hari Doss Chanchala Doss

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