$629 Find Cheap Flights from Knoxville to Guatemala - Compare and Save

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Guatemala departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Book Cheap Knoxville to Guatemala Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Guatemala that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Guatemala

Tue, Oct 27 - Tue, Nov 10
American Airlines Logo
6:06 pm - 11:04 am
TYS
-
GUA
18h 58m
2 stops
American Airlines Logo
6:00 am - 8:43 pm
GUA
-
TYS
13h 43m
2 stops
$629American Airlines
Tue, Oct 27 - Tue, Nov 10
American Airlines Logo
7:13 pm - 11:04 am
TYS
-
GUA
17h 51m
2 stops
American Airlines Logo
6:00 am - 10:01 pm
GUA
-
TYS
15h 01m
1 stop
$629American Airlines
Thu, Aug 20 - Sat, Aug 29
Multiple Airlines Logo
8:00 am - 8:51 pm
TYS
-
GUA
38h 51m
2 stops
Multiple Airlines Logo
2:47 pm - 12:05 pm
GUA
-
TYS
19h 18m
1 stop
$639Multiple Airlines
Tue, Oct 27 - Tue, Nov 10
American Airlines Logo
7:13 pm - 11:04 am
TYS
-
GUA
17h 51m
2 stops
American Airlines Logo
6:00 am - 10:01 pm
GUA
-
TYS
15h 01m
1 stop
$650American Airlines
Tue, Oct 27 - Tue, Nov 10
American Airlines Logo
7:13 pm - 11:04 am
TYS
-
GUA
17h 51m
2 stops
American Airlines Logo
6:00 am - 6:35 pm
GUA
-
TYS
11h 35m
2 stops
$650American Airlines
Tue, Oct 27 - Tue, Nov 10
Delta Logo
5:40 am - 11:32 am
TYS
-
GUA
7h 52m
1 stop
Delta Logo
2:10 pm - 10:22 pm
GUA
-
TYS
7h 12m
1 stop
$664Delta
Tue, Oct 27 - Tue, Nov 10
Delta Logo
5:40 am - 11:32 am
TYS
-
GUA
7h 52m
1 stop
Delta Logo
2:10 pm - 10:22 pm
GUA
-
TYS
7h 12m
1 stop
$667Delta
Thu, Aug 20 - Sat, Aug 29
Multiple Airlines Logo
2:21 pm - 11:10 pm
TYS
-
GUA
10h 49m
2 stops
Multiple Airlines Logo
5:25 am - 6:17 pm
GUA
-
TYS
10h 52m
2 stops
$705Multiple Airlines
Mon, Sep 7 - Mon, Sep 14
Delta Logo
7:30 am - 11:29 am
TYS
-
GUA
5h 59m
1 stop
Delta Logo
1:02 pm - 11:55 pm
GUA
-
TYS
8h 53m
1 stop
$710Delta
Fri, Oct 2 - Sat, Oct 10
American Airlines Logo
7:00 am - 6:29 pm
TYS
-
GUA
13h 29m
2 stops
American Airlines Logo
3:14 pm - 10:25 am
GUA
-
TYS
17h 11m
2 stops
$714American Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Guatemala flights

Get data-powered insights and trends into flights from Knoxville to Guatemala to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to Guatemala?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.

In the past 5 days, the cheapest round-trip tickets from Knoxville to Guatemala were found on Delta ($664) and American Airlines ($732).

Good to know

Cheapest flight

$629
Flight from Knoxville to Guatemala City

FAQs - booking Guatemala flights

  • How does KAYAK find such low prices on flights from Knoxville to Guatemala?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Guatemala.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Guatemala?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Knoxville to Guatemala is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Guatemala?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Knoxville to Guatemala with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Guatemala?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Knoxville to Guatemala up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Knoxville to Guatemala

 
Need help choosing which airline to fly with from Knoxville to Guatemala? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11845 reviews
7.2Comfort
6.8Entertainment
6.4Food
7.9Crew
7.5Boarding
Airline reviews

Not one thing to like. Three flights all with “mechanical” delays. Never got to where I was going and spent additional $500 for a hotel room. American Airlines is the worst in the industry!

2.0 MediocreJason, Jul 2026
CHA - DFW
Read more American Airlines reviews

Not one thing to like. Three flights all with “mechanical” delays. Never got to where I was going and spent additional $500 for a hotel room. American Airlines is the worst in the industry!

Air condition was not working for long both after boarding and also after landing ; unbearably hot and suffocating

It was canceled at the last minute. While I was literally at the airport. Messed my entire trip up.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Did not get any refreshments. Crew was very nice but limited. Small seats

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

I didn’t like anything, being platinum pro get you absolutely nowhere and does not increase the customer service treatment whatsoever anymore. My flight was canceled and they put me on a flight eight hours later that would’ve got me back in the middle of the night. They could’ve easily move me up to an hour Prior on an earlier flight. My second flight was unreasonable to take, the third flight was also canceled due to mechanical issues like the first flight. I don’t know what’s going on with American, but they are falling apart, after seven flight changes I finally got home, Unreasonable.

This was a horrible American Airlines experience, and it discourages me from flying with them again. It may have stemmed from a mechanical delay, but it appeared that the team was unprepared to respond to the delay. After boarding, we waited an hour before finally taking off. After landing at our destination, we waited an additional hour on the tarmac waiting for a gate (at 8:00pm) to be assigned and cleared. The flight crew did their best, but they were clearly tired and also ready to be done for the day. Because of the delay, I missed a connecting flight. It was a very poor experience.

Fantastic! If it had not been for a check-in agent in Knoxville I may have not gotten my passes on British Airways. I couldn’t check-in online because British Airways had messed us the info on my tickets to London & Inverness. AA’s was great! British Airways was a continuous series of delays and frustrations.

Wheelchair was waiting for me,changed to a better seat which was great as it's hard for me to walk

Everything you need to know for your flight from Knoxville to Guatemala

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