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ECP - TYS

$109 Find Cheap Flights from Panama City to Knoxville - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$217
Typical prices: $316-$476
American Airlines
Sat 11/3Sat 11/10
ECP - TYS • 1 stop
Cheapest one-way
$109
Typical prices: $203-$346
American Airlines
Sat 11/3
ECP - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Panama City and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
June
Cheapest • 29% price drop
November
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Atlanta Hartsfield-Jackson (ATL)
Cheapest • Avg $393 (round-trip)
Nashville Intl (BNA)
Shortest trip • 3h 23m (one-way)
Insights
Insights
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Cheap Flights from Panama City to Knoxville (ECP-TYS)

 

Cheap flights from Panama City to Knoxville with top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.

Tue, Nov 3 - Tue, Nov 10
American Airlines Logo
5:41 pm - 10:48 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
4h 07m1 stop Charlotte Douglas
American Airlines Logo
6:01 am - 11:30 amTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
6h 29m1 stop Charlotte Douglas
$217American Airlines
Tue, Nov 3 - Tue, Nov 10
Southwest Logo
7:55 am - 12:20 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
3h 25m1 stop Nashville Intl
Southwest Logo
7:55 am - 6:15 pmTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
11h 20m2 stops Baltimore/Washington Nashville Intl
$228Southwest
Tue, Nov 3 - Tue, Nov 10
Southwest Logo
7:30 am - 7:45 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
11h 15m2 stops Dallas Love Field Nashville Intl
Southwest Logo
7:55 am - 6:15 pmTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
11h 20m2 stops Baltimore/Washington Nashville Intl
$239Southwest
Fri, Oct 30 - Sun, Nov 1
American Airlines Logo
6:42 pm - 11:55 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
4h 13m1 stop Charlotte Douglas
American Airlines Logo
8:04 pm - 11:48 pmTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
4h 44m1 stop Charlotte Douglas
$340American Airlines
Fri, Jan 15 - Sun, Jan 17
Southwest Logo
7:50 am - 9:20 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
12h 30m2 stops Nashville Intl Baltimore/Washington
Southwest Logo
7:00 am - 9:45 amTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
3h 45m1 stop Nashville Intl
$361Southwest
Thu, Dec 31 - Mon, Jan 4
Delta Logo
8:06 am - 1:39 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
4h 33m1 stop Atlanta Hartsfield-Jackson
Delta Logo
8:47 am - 11:04 amTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
3h 17m1 stop Atlanta Hartsfield-Jackson
$363Delta
Fri, Jan 15 - Sun, Jan 17
Southwest Logo
7:50 am - 9:20 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
12h 30m2 stops Nashville Intl Baltimore/Washington
Southwest Logo
7:00 am - 3:15 pmTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
9h 15m2 stops Nashville Intl Dallas Love Field
$366Southwest
Fri, Oct 30 - Sun, Nov 1
Delta Logo
5:34 pm - 10:22 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
3h 48m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:38 pm - 7:53 pmTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
6h 15m1 stop Atlanta Hartsfield-Jackson
$392Delta
Fri, Jan 15 - Sun, Jan 17
Delta Logo
9:23 am - 3:05 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
4h 42m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 11:04 amTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
6h 04m1 stop Atlanta Hartsfield-Jackson
$393Delta
Thu, Dec 31 - Mon, Jan 4
American Airlines Logo
7:02 pm - 11:53 pmECP  Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson
3h 51m1 stop Charlotte Douglas
American Airlines Logo
8:01 pm - 11:40 pmTYS  Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches
4h 39m1 stop Charlotte Douglas
$407American Airlines

Price, demand and travel trends for Panama City to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Panama City to Knoxville?

Round-trip flights from Panama City to Knoxville typically range from $316 to $476. The lowest price found in the past 5 days was $217, on American Airlines.

What's the cheapest day of the week to fly from Panama City to Knoxville?

Based on deals KAYAK users found in the last 12 months, Saturday is the cheapest day of the week to fly from Panama City to Knoxville. It’s 29% cheaper than the average day, while Friday is the most expensive, with prices 29% higher.

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Key details for Panama City to Knoxville flights

Low season

March

Cheapest flight

$109
The most popular month to fly with an average 67% increase in travelers.
One-way flight from Panama City to Knoxville

When to book flights from Panama City to Knoxville

Are your dates flexible? Find out the best times to travel from Panama City to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Panama City to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Panama City to Knoxville?

    Only Economy Class is available on flights from Panama City to Knoxville.

  • How long is a flight from Panama City to Knoxville?

    A nonstop flight from Panama City to Knoxville takes 00m, covering 390 miles.

  • Do I need a passport to fly from Panama City to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Panama City to Knoxville flight?

    Round-trip flights from Panama City to Knoxville range from $316 to $476, with an average of $368 over the past 12 months. Anything below $316 counts as a good deal.

  • Have flight prices from Panama City to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $217 to $1,508. That means the highest observed fare was about 7x higher than the lowest one.

  • How are flight prices from Panama City to Knoxville looking right now?

    One-way fares from Panama City to Knoxville are currently lower than usual. Average one-way flight prices are about $189, which is 36% below the typical average for this route.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from Panama City to Knoxville?

    Flights from Panama City to Knoxville usually depart from Panama City NW Florida Beaches (ECP) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Panama City to Knoxville pass through?

    One-stop flights from Panama City to Knoxville most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 83% of one-stop connections
    • Charlotte Douglas (CLT) - 11% of one-stop connections
    • Nashville Intl (BNA) - 6% of one-stop connections

  • Can I save money by using flexible dates for flights from Panama City to Knoxville?

    Yes. Flexible dates can save you up to 46% on flights from Panama City to Knoxville. Saturday is the cheapest departure day at $262 round-trip on average, while Friday is the most expensive at $478, a difference of $216.

    Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

  • How much time can I save by choosing a different layover airport from Panama City to Knoxville?

    Flying via Nashville Intl (BNA) gives the shortest average 1-stop total travel time at 3h 23m, compared with 3h 54m via Atlanta Hartsfield-Jackson (ATL) and 5h 11m via Charlotte Douglas (CLT).

  • What is the time difference between Panama City and Knoxville?

    Knoxville is 1 hour ahead of Panama City (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Panama City to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Saturday departure and avoid flying on Friday. On this route, Saturday flights average $262, about $216 less than Friday fares (45% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Panama City to Knoxville trip for June. Fares historically average $262 round-trip in that month - typically $374 less than the most expensive month, which is August (based on the last 12 months).

More options for your flight from Panama City to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Car rentals in Knoxville
Hotels in Knoxville
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