ECP - TYS

$125 Find Cheap Flights from Panama City to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Knoxville departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$268
Typical prices: $496-$305
Southwest
Wed 6/3Mon 6/8
ECP - TYS • 1 stop
Cheapest one-way
$125
Typical prices: $228-$248
Delta
Tue 5/5
ECP - TYS • 1 stop
Top airlines
Cheapest • from $268 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $368 (round-trip)
Shortest trip • 3h 30m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 20% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to Knoxville (ECP-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Knoxville

Wed, Jun 3 - Mon, Jun 8
Southwest Logo
7:15 am - 12:00 pm
ECP
-
TYS
3h 45m
1 stop
Southwest Logo
6:40 am - 2:15 pm
TYS
-
ECP
8h 35m
1 stop
$268Southwest
Wed, Jun 3 - Mon, Jun 8
Southwest Logo
12:05 pm - 8:50 pm
ECP
-
TYS
7h 45m
2 stops
Southwest Logo
6:40 am - 2:15 pm
TYS
-
ECP
8h 35m
1 stop
$274Southwest
Wed, Jun 3 - Mon, Jun 8
Southwest Logo
10:10 am - 7:40 pm
ECP
-
TYS
8h 30m
2 stops
Southwest Logo
6:40 am - 12:45 pm
TYS
-
ECP
7h 05m
2 stops
$294Southwest
Tue, Aug 4 - Sat, Aug 8
Southwest Logo
7:45 am - 12:05 pm
ECP
-
TYS
3h 20m
1 stop
Southwest Logo
6:50 am - 11:05 am
TYS
-
ECP
5h 15m
1 stop
$299Southwest
Tue, Aug 4 - Sat, Aug 8
Southwest Logo
10:30 am - 6:55 pm
ECP
-
TYS
7h 25m
2 stops
Southwest Logo
6:50 am - 11:05 am
TYS
-
ECP
5h 15m
1 stop
$304Southwest
Tue, Aug 4 - Sat, Aug 8
Southwest Logo
9:10 am - 7:50 pm
ECP
-
TYS
9h 40m
2 stops
Southwest Logo
6:50 am - 2:55 pm
TYS
-
ECP
9h 05m
2 stops
$309Southwest
Mon, May 18 - Thu, May 21
Southwest Logo
7:10 am - 11:40 am
ECP
-
TYS
3h 30m
1 stop
Southwest Logo
6:35 am - 9:05 am
TYS
-
ECP
3h 30m
1 stop
$328Southwest
Mon, May 18 - Thu, May 21
Southwest Logo
6:40 am - 8:20 pm
ECP
-
TYS
12h 40m
2 stops
Southwest Logo
6:35 am - 9:05 am
TYS
-
ECP
3h 30m
1 stop
$339Southwest
Fri, May 8 - Sun, May 10
Delta Logo
6:45 pm - 11:56 pm
ECP
-
TYS
4h 11m
1 stop
Delta Logo
5:40 am - 8:30 am
TYS
-
ECP
3h 50m
1 stop
$359Delta
Fri, May 8 - Sun, May 10
Delta Logo
6:45 pm - 11:56 pm
ECP
-
TYS
4h 11m
1 stop
Delta Logo
7:33 pm - 11:28 pm
TYS
-
ECP
4h 55m
1 stop
$379Delta
Booking Insights

KAYAK's insights & trends for Panama City to Knoxville flights

Get data-powered insights and trends into flights from Panama City to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Panama City, Florida to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Panama City, Florida to Knoxville departing in June.

What is the cheapest month to fly from Panama City to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Knoxville is October, where tickets cost $326 (return) on average. On the other hand, the most expensive months are April and December, where the average cost of round-trip tickets is $556 and $548 respectively.

Good to know

Low seasonJanuary
Cheapest flight$125
Best time to beat the crowds with an average 18% drop in price.
Most popular time to fly with an average 2% increase in price.
Flight from Panama City to Knoxville

When to book flights from Panama City to Knoxville

Are your dates flexible? Find out the best times to travel from Panama City to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to Knoxville

  • What is the cheapest flight from Panama City to Knoxville?

    In the last 3 days, the lowest price for a flight from Panama City to Knoxville was $125 for a one-way ticket and $268 for a round-trip.

  • Do I need a passport to fly between Panama City and Knoxville?

    A passport is not required to fly from Panama City to Knoxville.

  • Which airports will I be using when flying from Panama City to Knoxville?

    Panama City and Knoxville are both served by 1 main airport. You will leave Panama City from Panama City NW Florida Beaches and will be arriving at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Panama City to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to Knoxville?

    oneworld, and SkyTeam are the airline alliances operating flights between Panama City and Knoxville, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from Panama City to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Panama City to Knoxville are Delta and American Airlines. With an average price for the route of $386 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $366 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Panama City to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Panama City with another airline. Booking your flights between Panama City and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8399 reviews
7.8Entertainment
7.2Food
8.5Crew
7.9Comfort
8.1Boarding
Airline reviews

On the return flight, flight attendant Britt went out of her way to inform passengers that several of us had tight connections.

10.0 ExcellentAnonymous, Apr 2026
MIA - DTW
Read more Delta reviews

On the return flight, flight attendant Britt went out of her way to inform passengers that several of us had tight connections.

Too many people are taking up space in the overhead bins with their extra piece of luggage. Since they cannot fit their backpacks or extra luggage piece under the seat in front of them, they store it in the overheads and thus taking up room for other passengers. It wasn’t only one or two persons; more like 12 or 13 passengers.

Kayak botched up the booking, i had to call delta and fix. In the process Delta failed to honor my comfort plus seat assignment that i had previously.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

Same experience as the flight from Norfolk to Atlanta where people are boarded in zones that don't make sense. People behind you on the plane will get on before you and they take the luggage space on your row.

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Delays experienced in boarding/take off due to incoming plane delayed. However, the boarding time/depart time in the app was significantly delayed in providing these updates. Usually not updated until an hour after we should have already boarded. Poorly managed.

Bag drop was very disorganized in Miami. All main cabin passengers were shunted to just a few lanes and they had an equal number of lanes for first class passengers but there was nobody on those lines. They did nothing to bring the main cab and passengers over to the open lines and they just had employees standing there and doing nothing

Crew at the gate was very crabby and not at all polite. The plane was very hot the entire flight. And the seat cushion was very worn out.

I have never been assaulted they way I was today in Charlotte - shame on American

The staff are very, very professional. It's what flying should feel like.

The flight attendant in business class was excellent! Professional, friendly and attentive.

A first class seat should fit a fat person, and this doesn't. The trays in the armrest are less functional than an ordinary tray in the back of the seat.

It was great. Smooth flight, comfortable, left on time and landed on time.

Really good. I accidentally left my duffel on the plane and the reps were so friendly in retrieving it.

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

Everything you need to know for your flight from Panama City to Knoxville

Information on your arrival and departure airports