ECP - TYS

$249 Find Cheap Flights from Panama City to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Knoxville departing on 11/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Knoxville, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Panama City to Knoxville (ECP-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Knoxville

Tue, Nov 4 - Sat, Nov 8
American Airlines Logo
5:50 pm - 10:51 pmECP-TYS
4h 01m1 stop
American Airlines Logo
8:04 pm - 11:53 pmTYS-ECP
4h 49m1 stop
$259American Airlines
Find Deal
Tue, Nov 4 - Sat, Nov 8
American Airlines Logo
5:50 pm - 10:51 pmECP-TYS
4h 01m1 stop
American Airlines Logo
8:04 pm - 11:53 pmTYS-ECP
4h 49m1 stop
$299American Airlines
Find Deal
Sat, Nov 1 - Sat, Nov 8
American Airlines Logo
5:30 am - 10:31 amECP-TYS
4h 01m1 stop
American Airlines Logo
8:04 pm - 11:53 pmTYS-ECP
4h 49m1 stop
$303American Airlines
Find Deal
Sat, Nov 1 - Sat, Nov 8
Delta Logo
5:00 pm - 11:07 pmECP-TYS
5h 07m1 stop
Delta Logo
2:41 pm - 6:34 pmTYS-ECP
4h 53m1 stop
$367Delta
Find Deal
Thu, Oct 16 - Mon, Oct 20
Delta Logo
6:17 pm - 11:46 pmECP-TYS
4h 29m1 stop
Delta Logo
8:10 pm - 11:10 pmTYS-ECP
4h 00m1 stop
$457Delta
Find Deal
Fri, Oct 17 - Sat, Oct 18
Delta Logo
6:17 pm - 11:46 pmECP-TYS
4h 29m1 stop
Delta Logo
6:15 am - 8:44 amTYS-ECP
3h 29m1 stop
$461Delta
Find Deal
Sat, Oct 18 - Tue, Oct 21
Delta Logo
5:32 pm - 11:07 pmECP-TYS
4h 35m1 stop
Delta Logo
5:44 am - 8:44 amTYS-ECP
4h 00m1 stop
$503Delta
Find Deal
Wed, Oct 29 - Fri, Oct 31
United Airlines Logo
6:30 am - 11:44 pmECP-TYS
16h 14m1 stop
United Airlines Logo
5:46 pm - 2:40 pmTYS-ECP
21h 54m2 stops
$576United Airlines
Find Deal
Sat, Nov 1 - Sat, Nov 8
United Airlines Logo
6:30 am - 11:44 pmECP-TYS
16h 14m1 stop
United Airlines Logo
8:50 am - 1:57 pmTYS-ECP
30h 07m2 stops
$586United Airlines
Find Deal
Tue, Nov 4 - Sat, Nov 8
United Airlines Logo
6:30 am - 11:44 pmECP-TYS
16h 14m1 stop
United Airlines Logo
8:50 am - 1:57 pmTYS-ECP
30h 07m2 stops
$594United Airlines
Find Deal

Everything you should know

Top airlines
American Airlines
Cheapest • from $259 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
August
Cheapest • 32% price drop
June
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Cheapest round-trip
$259
Overall average: $558
American Airlines
Tue 11/4Sat 11/8
ECP - TYS • 1 stop
Cheapest one-way
$249
Delta
Sat 11/8
ECP - TYS • 1 stop
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Booking Insights

KAYAK's insights & trends for Panama City to Knoxville flights

Get data-powered insights and trends into flights from Panama City to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Knoxville is August, where tickets cost $328 (return) on average. On the other hand, the most expensive months are January and November, where the average cost of round-trip tickets is $608 and $558 respectively.

Good to know

Low seasonMarch
Cheapest flight$249
Best time to beat the crowds but there is an average 15% increase in price.
Most popular time to fly and prices are also 2% lower on average.
Flight from Panama City to Knoxville

When to book flights from Panama City to Knoxville

Are your dates flexible? Find out the best times to travel from Panama City to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to Knoxville

  • What is the cheapest flight from Panama City to Knoxville?

    In the last 3 days, the lowest price for a flight from Panama City to Knoxville was $249 for a one-way ticket and $259 for a round-trip.

  • Do I need a passport to fly between Panama City and Knoxville?

    A passport is not required to fly from Panama City to Knoxville.

  • Which airports will I be using when flying from Panama City to Knoxville?

    Panama City and Knoxville are both served by 1 main airport. You will leave Panama City from Panama City NW Florida Beaches and will be arriving at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Panama City to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to Knoxville?

    oneworld, and SkyTeam are the airline alliances operating flights between Panama City and Knoxville, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from Panama City to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Panama City to Knoxville are Delta and American Airlines. With an average price for the route of $485 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $498 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Panama City to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Panama City with another airline. Booking your flights between Panama City and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7970 reviews
7.3Food
8.2Boarding
7.9Entertainment
8.5Crew
7.9Comfort
Airline reviews

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

8.0 ExcellentOlaf, Sep 2025FLL - ATL
Read more Delta reviews

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Flight was an hour late, who knows why. It was OK, nothing outstanding.

Excellent check-in. Crew was good. Excellent communication from flight deck.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

The Dekta Rep that checked us in was great. She's very personable, pleasant, and can tell she enjoys her job.

Kind staff. Snacks are small but that’s the new normal.

The young man who was our flight attendant in first class was lazy and did not do his job well at all. Never offered drinks upon boarding - actually I take that back... said "are you okay with water" as if I do not want to get you anything else, only passed the snacks around once, got my drink order wrong and then never offered a second round of drinks. He was the worst I have ever seen on Delta and we fly a lot.

We had 3 flights. 1 & 2 were on the same plane but we had to de-board just to re-board 30 mins later. That may have been due to a crew change though. Our 3rd flight had a couple “maintenance” issues that held us up. They were quickly resolved but it took forever for someone to bring the paperwork needed so we could leave. Apparently there was a computer glitch so a driver had to bring a physical copy. It delayed us about 1 1/2 hrs. The flights themselves were smooth & no problems. For boarding, I don’t know why they don’t start with the back of the plane & move forward. It would eliminate the back up from people trying to find their seats & put their bags in the overhead bins. Unless you’re on an overseas flight, there is no food, you get a beverage & either a small bag of pretzels or a biscuit cookie. Take your own food or snacks of you want something more.

Lost bag and 2 days no word leaving for cruise no clothes or stuff

We will be writing a long, detailed letter to corporate about our awful experience with American airlines.

Internet was a bit expensive and did not work ask that week otherwise a good flight

Food was ok, but not as good as I have had before on AA.

Pretty good. The food was just mediocre, the boarding and crew were good.

Crew should be nicer and emphatic with customers. Same cookies as the past 20 years. Seat are ok and the plane was clean though it was delayed.

Plane was delayed for 6 hours, at first by weather, which is understandable, but was further delayed with NO given reason for 2 1/2 hours more. We had no clue when we were going to depart actually until they opened the ramp. VERY POOR to ZERO COMMUNICATION!!!

It was very difficult to stretch my knee out and I am very short. I also had a torn tendon in my knee which made it extra uncomfortable anyways. My husband is 6'2" and I can't imagine him flying in that plane.

Delayed because of weather in Nashville. I think God or some higher power generally has cursed me when it comes to flying out of Charlotte on American. I'm delayed pretty much everytime. We need Team Cobra Kai types to come in and "sweep the leg(s)" of the Charlotte ops people on principle. Don't let the sweet southern rocking chairs fool you, Charlotte is a sinkhole

Everything you need to know for your flight from Panama City to Knoxville

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