ECP - TYS

$249 Find Cheap Flights from Panama City to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Knoxville departing on 2/14. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$308
Overall average: $541
Southwest
Fri 4/17Mon 4/20
ECP - TYS • 1 stop
Cheapest one-way
$249
Overall average: $154
Delta
Sat 2/14
ECP - TYS • 1 stop
Top airlines
Southwest
Cheapest • from $308 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
October
Cheapest • 30% price drop
June
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to Knoxville (ECP-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Knoxville

Fri, Apr 17 - Mon, Apr 20
Southwest Logo
7:10 am - 11:40 amECP-TYS
3h 30m1 stop
Southwest Logo
6:35 am - 9:05 amTYS-ECP
3h 30m1 stop
$308Southwest
Find Deal
Fri, Apr 17 - Mon, Apr 20
Southwest Logo
9:55 am - 9:15 pmECP-TYS
10h 20m2 stops
Southwest Logo
6:35 am - 9:05 amTYS-ECP
3h 30m1 stop
$313Southwest
Find Deal
Wed, Apr 15 - Sat, Apr 18
Delta Logo
6:00 am - 11:06 amECP-TYS
4h 06m1 stop
Delta Logo
10:05 am - 12:38 pmTYS-ECP
3h 33m1 stop
$317Delta
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Fri, Apr 17 - Mon, Apr 20
Southwest Logo
9:55 am - 9:15 pmECP-TYS
10h 20m2 stops
Southwest Logo
8:05 am - 7:35 pmTYS-ECP
12h 30m2 stops
$324Southwest
Find Deal
Sat, Dec 20 - Sun, Dec 21
American Airlines Logo
4:09 pm - 11:52 pmECP-TYS
6h 43m1 stop
American Airlines Logo
5:40 pm - 11:53 pmTYS-ECP
7h 13m1 stop
$343American Airlines
Find Deal
Fri, Apr 17 - Mon, Apr 20
Delta Logo
7:05 pm - 11:46 pmECP-TYS
3h 41m1 stop
Delta Logo
5:30 am - 8:17 amTYS-ECP
3h 47m1 stop
$363Delta
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Sat, Dec 20 - Sat, Jan 3
American Airlines Logo
4:09 pm - 11:52 pmECP-TYS
6h 43m1 stop
American Airlines Logo
7:00 am - 10:41 amTYS-ECP
4h 41m1 stop
$381American Airlines
Find Deal
Fri, Dec 5 - Sat, Dec 6
American Airlines Logo
8:30 am - 2:00 pmECP-TYS
4h 30m1 stop
American Airlines Logo
6:40 am - 9:59 amTYS-ECP
4h 19m1 stop
$407American Airlines
Find Deal
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
7:19 am - 6:36 pmECP-TYS
10h 17m2 stops
American Airlines Logo
6:00 am - 9:37 amTYS-ECP
4h 37m1 stop
$467American Airlines
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Fri, Apr 17 - Mon, Apr 20
American Airlines Logo
9:56 am - 5:33 pmECP-TYS
6h 37m1 stop
American Airlines Logo
9:05 am - 1:30 pmTYS-ECP
5h 25m1 stop
$525American Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Panama City to Knoxville flights

Get data-powered insights and trends into flights from Panama City to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Knoxville is October, where tickets cost $326 (return) on average. On the other hand, the most expensive months are January and March, where the average cost of round-trip tickets is $608 and $556 respectively.

Good to know

Low seasonMarch
Cheapest flight$249
Best time to beat the crowds but there is an average 19% increase in price.
Most popular time to fly with an average 1% increase in price.
Flight from Panama City to Knoxville

When to book flights from Panama City to Knoxville

Are your dates flexible? Find out the best times to travel from Panama City to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to Knoxville

  • What is the cheapest flight from Panama City to Knoxville?

    In the last 3 days, the lowest price for a flight from Panama City to Knoxville was $249 for a one-way ticket and $308 for a round-trip.

  • Do I need a passport to fly between Panama City and Knoxville?

    A passport is not required to fly from Panama City to Knoxville.

  • Which airports will I be using when flying from Panama City to Knoxville?

    Panama City and Knoxville are both served by 1 main airport. You will leave Panama City from Panama City NW Florida Beaches and will be arriving at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Panama City to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to Knoxville?

    oneworld, and SkyTeam are the airline alliances operating flights between Panama City and Knoxville, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from Panama City to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Panama City to Knoxville are Delta and American Airlines. With an average price for the route of $467 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $498 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Panama City to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Panama City with another airline. Booking your flights between Panama City and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8004 reviews
7.9Entertainment
8.5Crew
8.1Boarding
7.9Comfort
7.3Food
Airline reviews

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

10.0 ExcellentDuane, Nov 2025PBI - ATL
Read more Delta reviews

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

Non stop on long haul is the way to go. Great experience

The boarding process needs to be refined. Sometimes the gate crew call out the boarding zone, and then flip to the monitor to show which zones are boarding. So unless everyone is gathered around to see the monitor there is usually confusion as wi which zones are boarding.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Flight was an hour late, who knows why. It was OK, nothing outstanding.

Excellent check-in. Crew was good. Excellent communication from flight deck.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

I have a gluten allergy so didn't have any food

I enjoyed the extra leg room compared to other airlines. The first stewards made my daughter’s birthday special by giving her an extra snack. Then the last one coming home from Chicago to Appleton made our night really enjoyable Thanks for making our trip enjoyable

We had 3 flights. 1 & 2 were on the same plane but we had to de-board just to re-board 30 mins later. That may have been due to a crew change though. Our 3rd flight had a couple “maintenance” issues that held us up. They were quickly resolved but it took forever for someone to bring the paperwork needed so we could leave. Apparently there was a computer glitch so a driver had to bring a physical copy. It delayed us about 1 1/2 hrs. The flights themselves were smooth & no problems. For boarding, I don’t know why they don’t start with the back of the plane & move forward. It would eliminate the back up from people trying to find their seats & put their bags in the overhead bins. Unless you’re on an overseas flight, there is no food, you get a beverage & either a small bag of pretzels or a biscuit cookie. Take your own food or snacks of you want something more.

Lost bag and 2 days no word leaving for cruise no clothes or stuff

We will be writing a long, detailed letter to corporate about our awful experience with American airlines.

Internet was a bit expensive and did not work ask that week otherwise a good flight

Food was ok, but not as good as I have had before on AA.

Pretty good. The food was just mediocre, the boarding and crew were good.

Crew should be nicer and emphatic with customers. Same cookies as the past 20 years. Seat are ok and the plane was clean though it was delayed.

Everything you need to know for your flight from Panama City to Knoxville

Information on your arrival and departure airports