ECP - TYS

$129 Find Cheap Flights from Panama City to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Knoxville departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$268
Overall average: $527
Southwest
Sat 5/16Sun 5/17
ECP - TYS • 1 stop
Cheapest one-way
$129
Typical prices: $228-$248
Southwest
Sat 5/9
ECP - TYS • 1 stop
Top airlines
Southwest
Cheapest • from $268 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Charlotte (CLT)
Cheapest • Avg $418 (round-trip)
Atlanta (ATL)
Shortest trip • 3h 47m (one-way)
Insights
Insights
Insights
Insights
When to travel
October
Cheapest • 27% price drop
June
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to Knoxville (ECP-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Knoxville

Sat, May 16 - Sun, May 17
Southwest Logo
7:20 am - 11:40 am
ECP
-
TYS
3h 20m
1 stop
Southwest Logo
6:40 am - 9:10 am
TYS
-
ECP
3h 30m
1 stop
$268Southwest
Sat, May 16 - Sun, May 17
Southwest Logo
7:20 am - 11:40 am
ECP
-
TYS
3h 20m
1 stop
Southwest Logo
6:40 am - 12:15 pm
TYS
-
ECP
6h 35m
2 stops
$273Southwest
Fri, Jun 12 - Mon, Jun 15
Southwest Logo
6:55 am - 3:45 pm
ECP
-
TYS
7h 50m
1 stop
Southwest Logo
6:40 am - 9:35 am
TYS
-
ECP
3h 55m
1 stop
$279Southwest
Fri, Jun 12 - Mon, Jun 15
Southwest Logo
7:50 am - 12:00 pm
ECP
-
TYS
3h 10m
1 stop
Southwest Logo
6:40 am - 12:45 pm
TYS
-
ECP
7h 05m
2 stops
$284Southwest
Fri, Jun 12 - Mon, Jun 15
Southwest Logo
10:15 am - 9:10 pm
ECP
-
TYS
9h 55m
2 stops
Southwest Logo
12:35 pm - 8:10 pm
TYS
-
ECP
8h 35m
2 stops
$289Southwest
Fri, Jun 12 - Mon, Jun 15
Southwest Logo
10:15 am - 9:10 pm
ECP
-
TYS
9h 55m
2 stops
Southwest Logo
12:35 pm - 8:10 pm
TYS
-
ECP
8h 35m
2 stops
$299Southwest
Sat, Apr 11 - Sat, Apr 18
Southwest Logo
12:40 pm - 6:30 pm
ECP
-
TYS
4h 50m
1 stop
Southwest Logo
6:40 am - 9:00 am
TYS
-
ECP
3h 20m
1 stop
$307Southwest
Fri, Jun 12 - Mon, Jun 15
Delta Logo
2:47 pm - 9:44 pm
ECP
-
TYS
5h 57m
1 stop
Delta Logo
7:20 pm - 10:46 pm
TYS
-
ECP
4h 26m
1 stop
$338Delta
Fri, Apr 17 - Mon, Apr 20
Delta Logo
5:49 am - 11:17 am
ECP
-
TYS
4h 28m
1 stop
Delta Logo
5:54 pm - 9:22 pm
TYS
-
ECP
4h 28m
1 stop
$359Delta
Fri, Apr 17 - Mon, Apr 20
Delta Logo
5:49 am - 11:17 am
ECP
-
TYS
4h 28m
1 stop
Delta Logo
5:54 pm - 9:22 pm
TYS
-
ECP
4h 28m
1 stop
$369Delta
Booking Insights

KAYAK's insights & trends for Panama City to Knoxville flights

Get data-powered insights and trends into flights from Panama City to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Knoxville is October, where tickets cost $326 (return) on average. On the other hand, the most expensive months are February and March, where the average cost of round-trip tickets is $580 and $556 respectively.

Good to know

Low seasonJanuary
Cheapest flight$129
Best time to beat the crowds with an average 25% drop in price.
Most popular time to fly with an average 6% increase in price.
Flight from Panama City to Knoxville

When to book flights from Panama City to Knoxville

Are your dates flexible? Find out the best times to travel from Panama City to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to Knoxville

  • What is the cheapest flight from Panama City to Knoxville?

    In the last 3 days, the lowest price for a flight from Panama City to Knoxville was $129 for a one-way ticket and $268 for a round-trip.

  • Do I need a passport to fly between Panama City and Knoxville?

    A passport is not required to fly from Panama City to Knoxville.

  • Which airports will I be using when flying from Panama City to Knoxville?

    Panama City and Knoxville are both served by 1 main airport. You will leave Panama City from Panama City NW Florida Beaches and will be arriving at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Panama City to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to Knoxville?

    oneworld, and SkyTeam are the airline alliances operating flights between Panama City and Knoxville, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from Panama City to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Panama City to Knoxville are Delta and American Airlines. With an average price for the route of $386 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $422 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Panama City to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Panama City with another airline. Booking your flights between Panama City and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8236 reviews
7.8Entertainment
7.2Food
8.1Boarding
7.9Comfort
8.5Crew
Airline reviews

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

10.0 ExcellentSoosnata, Feb 2026
MIA - LAX
Read more Delta reviews

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

Smallest leg room I've ever had on a plane.

The flight was great as well as the airline staff

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

I have diamond medallion status and usually we are in comfort plus . We were in main this time ( which was fine ) and my husband wanted wine . I have at least 10 vouchers for drinks that are good for this year and next! The attendant would not take the picture of the voucher as proof and never came back to check as She asked me to pull it up on delta Wi-Fi. Instead my husband just used his Amex to buy the wine . Disappointing!!!

Everything was good. Flight was very full so crew was busy. After we boarded and plane pulled away from the gate, we were delayed about 40 minutes- sitting on the runway - due to weather en route or at the destination. While weather is not the fault of the airline- it’s terrible to sit on a plane and not moving.

The smell from the bathroom kept wafting through the cabin. It made people sick.

Waited for oxygen tanks for 30 minutes after boarding was complete.

Awful. Original flight was delayed 5 hours. Had to to take a connecting flight instead of direct. Had a 4 hour layover. I missed all of my morning meetings getting in 5 hours later than I was supposed to and had to change to take a later flight the next day to get them back in which cia time another $150.

Flight was smooth, quick and felt safe. The 2 delays not happening would have been better but I guess that happens in the airline industry

On time on a day with lots of weather cancellations on other flights. Thank you for getting me home during a winter storm!

Don't change gate multiple times make people run across the airport. Announce delays in a timely manner. Have maintenance crew ready. Don't delay and keep passengers on the plane for 3 hrs. on tarmac.

The attendants were kind and helpful. A sugar-free drink would have been very welcome.

Little warm on the plane and delayed for an hour

UGH I HAD TO MISS MY FIRST FLIGHT TO TAMPA CAUSE OF THE 10 MINUTE DELAY OF THE ORLANDO TO MIAMI ONE SO THEY HAD ME GET ANOTHER TICKET. I AM NOT HAPPY AT ALL BECAUSE IT MADE ME MISS MY CONNECTING FLIGHT FROM TAMPA TO LONDON AND FORCED ME TO MISS A DAY AT MY ROOM IN THE UK.

Everything you need to know for your flight from Panama City to Knoxville

Information on your arrival and departure airports