Which airports can I use when flying from Panama City to Knoxville?

Flights from Panama City to Knoxville usually depart from Panama City NW Florida Beaches (ECP) and arrive at Knoxville McGhee Tyson (TYS).

What cabin classes can I book on flights from Panama City to Knoxville?

Only Economy Class is available on flights from Panama City to Knoxville.

Which airports do connecting flights from Panama City to Knoxville pass through?

One-stop flights from Panama City to Knoxville most commonly connect through: • Atlanta Hartsfield-Jackson (ATL) - 74% of one-stop connections • Charlotte Douglas (CLT) - 21% of one-stop connections • Nashville Intl (BNA) - 5% of one-stop connections Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

Can I save money by using flexible dates for flights from Panama City to Knoxville?

On the Panama City to Knoxville route, being flexible with your departure day can save you up to 41%. Saturday is the cheapest day at $327 round-trip on average, while Monday is the most expensive at $548: a $221 difference. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

How long is a flight from Panama City to Knoxville?

A nonstop flight from Panama City to Knoxville takes 0h 00m, covering 390 miles.

What are the earliest and latest flights from Panama City to Knoxville?

These are the earliest and latest flight times available from Panama City to Knoxville: • Earliest: departs at 12:00 am and lands at 12:00 am • Latest: departs at 12:00 am and lands at 12:00 am. The flight takes about 0h 00m.

Do I need a passport to fly from Panama City to Knoxville?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Have flight prices from Panama City to Knoxville changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $243 to $1,307. That means the highest observed fare was about 5x higher than the lowest one.

How are flight prices from Panama City to Knoxville looking right now?

One-way fares from Panama City to Knoxville are currently lower than usual. Average one-way flight prices are about $136, which is 53% below the typical average for this route.

How much time can I save by choosing a different layover airport from Panama City to Knoxville?

Flying via Nashville Intl (BNA) gives the shortest average 1-stop total travel time at 3h 23m, compared with 3h 57m via Atlanta Hartsfield-Jackson (ATL) and 4h 52m via Charlotte Douglas (CLT).

What is the time difference between Panama City and Knoxville?

Knoxville is 1 hour ahead of Panama City (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include: · Budget · Alamo · Thrifty · Enterprise Rent-A-Car · Payless

How much should I expect to pay for a Panama City to Knoxville flight?

Round-trip flights from Panama City to Knoxville range from $327 to $476, with an average of $366 over the past 12 months. Anything below $327 counts as a good deal.

What is the cheapest airline to fly from Panama City to Knoxville?

Delta ($243) and American Airlines ($266) are the cheapest airlines to fly round-trip from Panama City to Knoxville according to KAYAK data over the last 5 days.

What is the most popular layover airport when flying from Panama City to Knoxville?

Atlanta Hartsfield-Jackson (ATL) is the most popular layover for the Panama City to Knoxville route. 74% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via ATL.

What is the cheapest layover airport when flying from Panama City to Knoxville?

Flights via Atlanta Hartsfield-Jackson (ATL) offer the most affordable fares, with an average round-trip price of $399. Based on KAYAK data over the past 3 months.

When flying from Panama City to Knoxville which airport offers the shortest layover?

Nashville Intl (BNA) had the shortest average connection time for Panama City to Knoxville layovers at 126 minutes over the past 3 months.

$122 CHEAP FLIGHTS from Panama City to Knoxville (ECP - TYS)

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$243

Typical prices: $327-$476

Delta

Wed 9/19Sun 9/23

ECP - TYS • 1 stop

Cheapest one-way

$122

Typical prices: $203-$349

Delta

Sun 9/9

ECP - TYS • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Panama City and Knoxville. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

June

Cheapest • 28% price drop

November

Most popular

Good to know

Top layover airports

Atlanta Hartsfield-Jackson (ATL)

Cheapest • Avg $399 (round-trip)

Nashville Intl (BNA)

Shortest trip • 3h 23m (one-way)

Insights

Start a new search

KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to Knoxville!

Flight Deals

Cheap Flights from Panama City to Knoxville (ECP-TYS)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Panama City to Knoxville

Sat, Sep 19 - Wed, Sep 23

6:00 am - 10:44 amECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

3h 44m1 stop Atlanta Hartsfield-Jackson

5:40 am - 8:16 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 36m1 stop Atlanta Hartsfield-Jackson

$243Delta

Mon, Sep 21 - Sat, Sep 26

7:35 am - 1:21 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 46m1 stop Atlanta Hartsfield-Jackson

11:39 am - 3:31 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 52m1 stop Atlanta Hartsfield-Jackson

$243Delta

Tue, Sep 22 - Sat, Sep 26

5:30 pm - 11:55 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

5h 25m1 stop Atlanta Hartsfield-Jackson

11:39 am - 3:31 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 52m1 stop Atlanta Hartsfield-Jackson

$243Delta

Mon, Sep 21 - Mon, Sep 28

7:35 am - 1:21 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 46m1 stop Atlanta Hartsfield-Jackson

10:26 am - 3:31 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

6h 05m1 stop Atlanta Hartsfield-Jackson

$243Delta

Tue, Sep 22 - Mon, Sep 28

9:23 am - 1:21 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

2h 58m1 stop Atlanta Hartsfield-Jackson

7:25 pm - 11:25 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

5h 00m1 stop Atlanta Hartsfield-Jackson

$243Delta

Mon, Sep 21 - Tue, Sep 29

7:35 am - 1:21 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 46m1 stop Atlanta Hartsfield-Jackson

5:40 am - 8:16 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 36m1 stop Atlanta Hartsfield-Jackson

$243Delta

Sat, Sep 19 - Sat, Sep 26

6:00 am - 10:44 amECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

3h 44m1 stop Atlanta Hartsfield-Jackson

5:40 am - 10:34 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

5h 54m1 stop Atlanta Hartsfield-Jackson

$243Delta

Wed, Sep 23 - Tue, Sep 29

5:30 pm - 11:55 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

5h 25m1 stop Atlanta Hartsfield-Jackson

4:40 pm - 7:08 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 28m1 stop Atlanta Hartsfield-Jackson

$243Delta

Fri, Dec 4 - Wed, Dec 9

7:01 pm - 11:58 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

3h 57m1 stop Charlotte Douglas

2:13 pm - 5:09 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 56m1 stop Charlotte Douglas

$266American Airlines

Tue, Sep 22 - Sat, Sep 26

7:45 am - 12:05 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

3h 20m1 stop Nashville Intl

6:50 am - 12:40 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

6h 50m2 stops Nashville Intl Houston Hobby

$291Southwest

Recent last minute flight deals from Panama City to Knoxville

Fri, Aug 28 - Sat, Aug 29

1:53 pm - 8:03 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

5h 10m1 stop Atlanta Hartsfield-Jackson

1:17 pm - 4:02 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 45m1 stop Atlanta Hartsfield-Jackson

$637Delta

Thu, Aug 27 - Wed, Sep 2

5:48 pm - 10:58 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 10m1 stop Charlotte Douglas

5:15 am - 11:12 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

6h 57m1 stop Charlotte Douglas

$637American Airlines

Thu, Aug 27 - Wed, Sep 2

1:30 pm - 6:35 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 05m1 stop Nashville Intl

8:05 am - 6:10 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

11h 05m2 stops Baltimore/Washington Nashville Intl

$642Southwest

Thu, Aug 27 - Wed, Sep 2

10:00 am - 7:55 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

8h 55m2 stops Chicago Midway Baltimore/Washington

8:05 am - 6:10 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

11h 05m2 stops Baltimore/Washington Nashville Intl

$647Southwest

Thu, Aug 27 - Wed, Sep 2

5:48 pm - 10:58 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 10m1 stop Charlotte Douglas

5:15 am - 11:12 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

6h 57m1 stop Charlotte Douglas

$662American Airlines

Tue, Aug 25 - Sat, Aug 29

5:48 pm - 10:58 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 10m1 stop Charlotte Douglas

7:25 pm - 10:40 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

4h 15m1 stop Charlotte Douglas

$662American Airlines

Tue, Aug 25 - Sat, Aug 29

11:30 am - 7:50 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

7h 20m2 stops Nashville Intl Baltimore/Washington

7:50 am - 1:55 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

7h 05m1 stop Baltimore/Washington

$667Southwest

Tue, Aug 25 - Sat, Aug 29

9:10 am - 7:50 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

9h 40m2 stops Dallas Love Field Baltimore/Washington

6:50 am - 12:40 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

6h 50m2 stops Nashville Intl Houston Hobby

$672Southwest

Fri, Aug 28 - Sat, Aug 29

4:10 pm - 10:00 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

4h 50m1 stop Atlanta Hartsfield-Jackson

6:00 am - 8:31 amTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

3h 31m1 stop Atlanta Hartsfield-Jackson

$687Delta

Thu, Aug 27 - Wed, Sep 2

6:40 am - 1:31 pmECP Panama City NW Florida Beaches-TYS Knoxville McGhee Tyson

5h 51m1 stop Charlotte Douglas

1:16 pm - 10:40 pmTYS Knoxville McGhee Tyson-ECP Panama City NW Florida Beaches

10h 24m2 stops Chicago O'Hare Intl Charlotte Douglas

$846American Airlines

Booking Insights

Price, demand and travel trends for Panama City to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Panama City to Knoxville with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Panama City to Knoxville?

Round-trip flights from Panama City to Knoxville start at $243. Prices are below average for this route right now, with typical round-trip fares ranging from $327 to $476. The lowest price found in the past 5 days was $243 on Delta.

What's the cheapest day of the week to fly from Panama City to Knoxville?

Saturday is the cheapest day of the week to fly from Panama City to Knoxville, it is 11% cheaper than the average day. Monday is the most expensive day with flight prices 49% higher than average. Based on deals found by KAYAK users in the last 12 months.

Find deals

Low season	March
High season	November
Cheapest flight	$122

Best time to beat the crowds but there is an average 21% increase in price.

Most popular time to fly with an average 10% increase in price.

Flight from Panama City to Knoxville

When to book flights from Panama City to Knoxville

Are your dates flexible? Find out the best times to travel from Panama City to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

Which airports can I use when flying from Panama City to Knoxville?
Flights from Panama City to Knoxville usually depart from Panama City NW Florida Beaches (ECP) and arrive at Knoxville McGhee Tyson (TYS).
What cabin classes can I book on flights from Panama City to Knoxville?
Only Economy Class is available on flights from Panama City to Knoxville.
Which airports do connecting flights from Panama City to Knoxville pass through?
One-stop flights from Panama City to Knoxville most commonly connect through:

• Atlanta Hartsfield-Jackson (ATL) - 74% of one-stop connections
• Charlotte Douglas (CLT) - 21% of one-stop connections
• Nashville Intl (BNA) - 5% of one-stop connections

Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.
Can I save money by using flexible dates for flights from Panama City to Knoxville?
On the Panama City to Knoxville route, being flexible with your departure day can save you up to 41%. Saturday is the cheapest day at $327 round-trip on average, while Monday is the most expensive at $548: a $221 difference. Cheaper weekend fares like these are typical of routes dominated by weekday business travel.
How long is a flight from Panama City to Knoxville?
A nonstop flight from Panama City to Knoxville takes 0h 00m, covering 390 miles.
What are the earliest and latest flights from Panama City to Knoxville?
These are the earliest and latest flight times available from Panama City to Knoxville:

• Earliest: departs at 12:00 am and lands at 12:00 am
• Latest: departs at 12:00 am and lands at 12:00 am.

The flight takes about 0h 00m.
Do I need a passport to fly from Panama City to Knoxville?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.
Have flight prices from Panama City to Knoxville changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $243 to $1,307. That means the highest observed fare was about 5x higher than the lowest one.
How are flight prices from Panama City to Knoxville looking right now?
One-way fares from Panama City to Knoxville are currently lower than usual. Average one-way flight prices are about $136, which is 53% below the typical average for this route.
How much time can I save by choosing a different layover airport from Panama City to Knoxville?
Flying via Nashville Intl (BNA) gives the shortest average 1-stop total travel time at 3h 23m, compared with 3h 57m via Atlanta Hartsfield-Jackson (ATL) and 4h 52m via Charlotte Douglas (CLT).
What is the time difference between Panama City and Knoxville?
Knoxville is 1 hour ahead of Panama City (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.
What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?
Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
· Budget
· Alamo
· Thrifty
· Enterprise Rent-A-Car
· Payless
How much should I expect to pay for a Panama City to Knoxville flight?
Round-trip flights from Panama City to Knoxville range from $327 to $476, with an average of $366 over the past 12 months. Anything below $327 counts as a good deal.

If your dates can be flexible, aim for a Saturday departure instead of Monday. On this route, Saturday flights average $327 - about $221 less than Monday (40% savings) based on the last 12 months.
If you can choose when to travel, plan your Panama City to Knoxville trip for June. Fares historically average $262 round-trip in that month - typically $444 less than the most expensive month, which is September (based on the last 12 months).

Everything you need to know for your flight from Panama City to Knoxville

Airports

Cabin class

Complete your trip

Direct Flights

Flights to other cities

Origins

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Return flight deals

Information on your arrival and departure airports

Panama City (ECP)

Knoxville (TYS)

ECP - TYS

$122 Find Cheap Flights from Panama City to Knoxville - Compare and Save

Everything you should know

Cheap Flights from Panama City to Knoxville (ECP-TYS)

Recent round-trip flight deals from Panama City to Knoxville

Recent one-way flight deals from Panama City to Knoxville

Recent last minute flight deals from Panama City to Knoxville

Price, demand and travel trends for Panama City to Knoxville flights

How much is a round-trip flight from Panama City to Knoxville?

What's the cheapest day of the week to fly from Panama City to Knoxville?

What is the cheapest airline to fly from Panama City to Knoxville?

What is the most popular layover airport when flying from Panama City to Knoxville?

What is the cheapest layover airport when flying from Panama City to Knoxville?

When flying from Panama City to Knoxville which airport offers the shortest layover?

Key details for Panama City to Knoxville flights

Low season

High season

Cheapest flight

When to book flights from Panama City to Knoxville

Your Panama City to Knoxville flight questions, answered

Your guide to booking Panama City to Knoxville flights

Everything you need to know for your flight from Panama City to Knoxville

Information on your arrival and departure airports

Cabin class types available on flights from Panama City to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Find direct flights to and from Panama City and Knoxville

Flights to other popular destinations

Flights from domestic origins to Knoxville

Choose which airport to fly into in Knoxville

Find deals for your return flight