Which airports can I use when flying from Knoxville to San Francisco?

Flights from Knoxville to San Francisco usually depart from Knoxville McGhee Tyson (TYS) and arrive at San Francisco (SFO).

What cabin classes can I book on flights from Knoxville to San Francisco?

Two cabin classes are available on flights from Knoxville to San Francisco: • Economy Class • First Class

Which airports do connecting flights from Knoxville to San Francisco pass through?

One-stop flights from Knoxville to San Francisco most commonly connect through: • Dallas/Fort Worth (DFW) - 37% of one-stop connections • Atlanta Hartsfield-Jackson (ATL) - 25% of one-stop connections • Denver Intl (DEN) - 21% of one-stop connections • Charlotte Douglas (CLT) - 7% of one-stop connections

Can I save money by using flexible dates for flights from Knoxville to San Francisco?

Yes. Flexible dates can save you up to 34% on flights from Knoxville to San Francisco. Thursday is the cheapest departure day at $377 round-trip on average, while Sunday is the most expensive at $566, a difference of $189. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

What popular places can I visit in San Francisco?

Some of the most popular sights in San Francisco are Fisherman's Wharf, Union Square and Moscone Center. These are among the most viewed places in San Francisco on KAYAK.

How expensive are last-minute Knoxville to San Francisco flights?

Last-minute fares on this route (booked within two weeks of departure) run 23% above the $435 route average. Book 19 weeks before departure for the lowest fares.

How long is a flight from Knoxville to San Francisco?

A nonstop flight from Knoxville to San Francisco takes 00m, covering 2,114 miles.

Do I need a passport to fly from Knoxville to San Francisco?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Have flight prices from Knoxville to San Francisco changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $289 to $2,026. That means the highest observed fare was about 7x higher than the lowest one.

How are flight prices from Knoxville to San Francisco looking right now?

One-way fares from Knoxville to San Francisco are currently lower than usual. Average one-way flight prices are about $219, which is 29% below the typical average for this route.

How much time can I save by choosing a different layover airport from Knoxville to San Francisco?

Flying via Dallas/Fort Worth (DFW) gives the shortest average 1-stop total travel time at 7h 29m, compared with 7h 29m via Atlanta Hartsfield-Jackson (ATL) and 7h 44m via Chicago O'Hare Intl (ORD).

What is the time difference between Knoxville and San Francisco?

San Francisco is 3 hours behind Knoxville (Pacific Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at San Francisco Airport (SFO)?

San Francisco Airport (SFO) hosts 5 major car rental companies, with daily rates averaging $63 for economy cars. Top options include: • Europcar • Thrifty • Dollar • Hertz • Fox

How much should I expect to pay for a Knoxville to San Francisco flight?

Round-trip flights from Knoxville to San Francisco range from $357 to $583, with an average of $435 over the past 12 months. Anything below $357 counts as a good deal.

What's the cheapest day of the week to fly from Knoxville to San Francisco?

Based on deals KAYAK users found in the last 12 months, Thursday is the cheapest day of the week to fly from Knoxville to San Francisco. It’s 14% cheaper than the average day, while Sunday is the most expensive, with prices 30% higher.

What’s the cheapest month to fly from Knoxville to San Francisco?

•February is the cheapest month to fly from Knoxville to San Francisco at $329 round-trip. •May ($658) and June ($626) are the most expensive months. •The price difference between flying in the cheapest and most expensive months is 100% on average. This is based on KAYAK aggregated and averaged internal data over the past 12 months.

When are flights from Knoxville to San Francisco the cheapest?

Flights from Knoxville to San Francisco are cheapest 19 weeks before departure. Booking in this window typically costs about 41% less than the average last-minute fare (within 2 weeks of the flight), based on KAYAK data.

Which airline is the cheapest to fly from Knoxville to San Francisco?

American Airlines ($377) and Delta ($377) are the cheapest airlines to fly round-trip from Knoxville to San Francisco according to KAYAK data over the last 5 days.

What’s the most popular layover airport when flying from Knoxville to San Francisco?

Dallas/Fort Worth (DFW) is the most popular layover for the Knoxville to San Francisco route. 37% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via DFW.

What is the cheapest layover airport when flying from Knoxville to San Francisco?

Flights via Denver Intl (DEN) offer the most affordable fares, with an average round-trip price of $380. Based on KAYAK data over the past 3 months.

When flying from Knoxville to San Francisco which airport offers the shortest layover?

Dallas/Fort Worth (DFW) had the shortest average connection time for Knoxville to San Francisco layovers at 4h 20m over the past 3 months.

$189 CHEAP FLIGHTS from Knoxville to San Francisco (TYS - SFO)

Save 26% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$289

Typical prices: $357-$583

Multiple Airlines

Fri 12/14Mon 12/17

TYS - SFO • 1 stop

Cheapest one-way

$189

Typical prices: $232-$400

Delta

Sun 12/2

TYS - SFO • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Knoxville and San Francisco. You'll need to take a connecting flight to reach the destination.

Insights

When to book

19 weeks

in advance

Our data shows that travelers who book at least 19 weeks in advance save around 41% compared to booking last minute.

Insights

When to travel

February

Cheapest • 24% price drop

July

Most popular

Good to know

Top layover airports

Denver Intl (DEN)

Cheapest • Avg $380 (round-trip)

Dallas/Fort Worth (DFW)

Shortest trip • 7h 29m (one-way)

Insights

Start a new search

KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to San Francisco!

Flight Deals

Cheap Flights from Knoxville to San Francisco (TYS-SFO)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Knoxville to San Francisco

Mon, Dec 14 - Thu, Dec 17

9:15 pm - 9:34 amTYS Knoxville McGhee Tyson-SFO San Francisco

15h 19m1 stop Las Vegas Harry Reid Intl

8:44 am - 12:41 pmSFO San Francisco-TYS Knoxville McGhee Tyson

24h 57m1 stop Las Vegas Harry Reid Intl

$289Multiple Airlines

Mon, Feb 22 - Fri, Feb 26

1:52 pm - 12:49 pmTYS Knoxville McGhee Tyson-SFO San Francisco

25h 57m1 stop Las Vegas Harry Reid Intl

10:28 am - 11:14 pmSFO San Francisco-TYS Knoxville McGhee Tyson

9h 46m1 stop Las Vegas Harry Reid Intl

$306Multiple Airlines

Mon, Dec 14 - Wed, Dec 16

9:15 pm - 9:34 amTYS Knoxville McGhee Tyson-SFO San Francisco

15h 19m1 stop Las Vegas Harry Reid Intl

9:31 pm - 10:14 pmSFO San Francisco-TYS Knoxville McGhee Tyson

21h 43m2 stops Los Angeles Phoenix Sky Harbor Intl

$306Multiple Airlines

Wed, Nov 25 - Tue, Dec 1

5:01 pm - 11:10 pmTYS Knoxville McGhee Tyson-SFO San Francisco

9h 09m1 stop Charlotte Douglas

5:00 am - 3:21 pmSFO San Francisco-TYS Knoxville McGhee Tyson

7h 21m1 stop Charlotte Douglas

$377American Airlines

Wed, Jan 27 - Thu, Feb 4

4:20 pm - 10:53 pmTYS Knoxville McGhee Tyson-SFO San Francisco

9h 33m1 stop Charlotte Douglas

8:24 am - 6:42 pmSFO San Francisco-TYS Knoxville McGhee Tyson

7h 18m1 stop Charlotte Douglas

$377American Airlines

Wed, Dec 2 - Thu, Dec 10

7:45 pm - 1:30 amTYS Knoxville McGhee Tyson-SFO San Francisco

8h 45m1 stop Washington, D.C. Dulles Intl

5:00 am - 2:40 pmSFO San Francisco-TYS Knoxville McGhee Tyson

6h 40m1 stop Denver Intl

$377United Airlines

Thu, Dec 3 - Thu, Dec 10

4:43 pm - 9:23 pmTYS Knoxville McGhee Tyson-SFO San Francisco

7h 40m1 stop Denver Intl

11:40 pm - 10:14 amSFO San Francisco-TYS Knoxville McGhee Tyson

7h 34m1 stop Chicago O'Hare Intl

$377United Airlines

Fri, Jan 29 - Thu, Feb 4

7:08 am - 12:42 pmTYS Knoxville McGhee Tyson-SFO San Francisco

8h 34m1 stop Atlanta Hartsfield-Jackson

8:00 am - 8:03 pmSFO San Francisco-TYS Knoxville McGhee Tyson

9h 03m1 stop Atlanta Hartsfield-Jackson

$377Delta

Tue, Jan 5 - Wed, Feb 3

5:30 am - 10:27 amTYS Knoxville McGhee Tyson-SFO San Francisco

7h 57m1 stop Dallas/Fort Worth

8:24 am - 6:42 pmSFO San Francisco-TYS Knoxville McGhee Tyson

7h 18m1 stop Charlotte Douglas

$377American Airlines

Sat, Dec 12 - Wed, Dec 16

5:40 am - 10:35 amTYS Knoxville McGhee Tyson-SFO San Francisco

7h 55m1 stop Atlanta Hartsfield-Jackson

6:00 am - 3:13 pmSFO San Francisco-TYS Knoxville McGhee Tyson

6h 13m1 stop Atlanta Hartsfield-Jackson

$399Delta

Recent last minute flight deals from Knoxville to San Francisco

Wed, Nov 11 - Wed, Nov 18

5:40 am - 10:41 amTYS Knoxville McGhee Tyson-SFO San Francisco

8h 01m1 stop Atlanta Hartsfield-Jackson

6:00 am - 3:15 pmSFO San Francisco-TYS Knoxville McGhee Tyson

6h 15m1 stop Atlanta Hartsfield-Jackson

$510Delta

Thu, Nov 12 - Wed, Nov 18

7:45 am - 10:29 pmTYS Knoxville McGhee Tyson-SFO San Francisco

17h 44m2 stops Washington, D.C. Dulles Intl Dallas/Fort Worth

5:07 pm - 10:12 pmSFO San Francisco-TYS Knoxville McGhee Tyson

26h 05m1 stop Phoenix Sky Harbor Intl

$563Multiple Airlines

Tue, Nov 10 - Wed, Nov 11

6:45 am - 11:50 amTYS Knoxville McGhee Tyson-SFO San Francisco

8h 05m1 stop Chicago O'Hare Intl

5:00 am - 3:01 pmSFO San Francisco-TYS Knoxville McGhee Tyson

7h 01m1 stop Denver Intl

$607United Airlines

Wed, Nov 11 - Wed, Nov 18

6:10 pm - 10:49 pmTYS Knoxville McGhee Tyson-SFO San Francisco

7h 39m1 stop Atlanta Hartsfield-Jackson

6:00 am - 4:20 pmSFO San Francisco-TYS Knoxville McGhee Tyson

7h 20m1 stop Minneapolis St Paul

$607Delta

Tue, Nov 10 - Wed, Nov 11

6:10 pm - 10:49 pmTYS Knoxville McGhee Tyson-SFO San Francisco

7h 39m1 stop Atlanta Hartsfield-Jackson

10:59 pm - 11:28 amSFO San Francisco-TYS Knoxville McGhee Tyson

9h 29m1 stop Atlanta Hartsfield-Jackson

$607Delta

Tue, Nov 10 - Wed, Nov 11

7:55 am - 1:50 pmTYS Knoxville McGhee Tyson-SFO San Francisco

8h 55m1 stop Baltimore/Washington

5:05 am - 7:50 pmSFO San Francisco-TYS Knoxville McGhee Tyson

11h 45m2 stops Phoenix Sky Harbor Intl Nashville Intl

$612Southwest

Tue, Nov 10 - Wed, Nov 11

7:05 am - 2:00 pmTYS Knoxville McGhee Tyson-SFO San Francisco

9h 55m2 stops Nashville Intl Denver Intl

6:10 am - 7:50 pmSFO San Francisco-TYS Knoxville McGhee Tyson

10h 40m2 stops Denver Intl Nashville Intl

$617Southwest

Tue, Nov 10 - Tue, Dec 8

10:33 am - 3:35 pmTYS Knoxville McGhee Tyson-SFO San Francisco

8h 02m1 stop Chicago O'Hare Intl

11:10 pm - 10:14 amSFO San Francisco-TYS Knoxville McGhee Tyson

8h 04m1 stop Chicago O'Hare Intl

$622United Airlines

Wed, Nov 11 - Sun, Nov 15

5:32 pm - 12:39 amTYS Knoxville McGhee Tyson-SFO San Francisco

10h 07m1 stop Dallas/Fort Worth

8:00 am - 7:34 pmSFO San Francisco-TYS Knoxville McGhee Tyson

8h 34m1 stop Charlotte Douglas

$692American Airlines

Wed, Nov 11 - Sun, Nov 15

5:19 pm - 10:32 pmTYS Knoxville McGhee Tyson-SFO San Francisco

8h 13m1 stop Charlotte Douglas

12:39 pm - 11:32 pmSFO San Francisco-TYS Knoxville McGhee Tyson

7h 53m1 stop Dallas/Fort Worth

$692American Airlines

Booking Insights

Price, demand and travel trends for Knoxville to San Francisco flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Prices

Airlines

Layovers

What's the cheapest day of the week to fly from Knoxville to San Francisco?: Based on deals KAYAK users found in the last 12 months, Thursday is the cheapest day of the week to fly from Knoxville to San Francisco. It’s 14% cheaper than the average day, while Sunday is the most expensive, with prices 30% higher.
What’s the cheapest month to fly from Knoxville to San Francisco? KAYAK internal proprietary data takes all prices for each month over the last 12 months for round-trip flights from Knoxville to San Francisco, removes the top 0.1% to account for outliers and then takes the median of all values for each month.: •February is the cheapest month to fly from Knoxville to San Francisco at $329 round-trip.
•May ($658) and June ($626) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 100% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.
When are flights from Knoxville to San Francisco the cheapest?: Flights from Knoxville to San Francisco are cheapest 19 weeks before departure. Booking in this window typically costs about 41% less than the average last-minute fare (within 2 weeks of the flight), based on KAYAK data.

Find deals

Low season	April
High season	July
Cheapest flight	$189

Beat the crowds with an average 34% drop in travelers.

The most popular month to fly with an average 31% increase in travelers.

One-way flight from Knoxville to San Francisco

When to book flights from Knoxville to San Francisco

Are your dates flexible? Find out the best times to travel from Knoxville to San Francisco based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

What cabin classes can I book on flights from Knoxville to San Francisco?
Two cabin classes are available on flights from Knoxville to San Francisco:

• Economy Class
• First Class
How long is a flight from Knoxville to San Francisco?
A nonstop flight from Knoxville to San Francisco takes 00m, covering 2,114 miles.
Do I need a passport to fly from Knoxville to San Francisco?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.
How much should I expect to pay for a Knoxville to San Francisco flight?
Round-trip flights from Knoxville to San Francisco range from $357 to $583, with an average of $435 over the past 12 months. Anything below $357 counts as a good deal.
How expensive are last-minute Knoxville to San Francisco flights?
Last-minute fares on this route (booked within two weeks of departure) run 23% above the $435 route average. Book 19 weeks before departure for the lowest fares.
Have flight prices from Knoxville to San Francisco changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $289 to $2,026. That means the highest observed fare was about 7x higher than the lowest one.
How are flight prices from Knoxville to San Francisco looking right now?
One-way fares from Knoxville to San Francisco are currently lower than usual. Average one-way flight prices are about $219, which is 29% below the typical average for this route.
What car rental options are available at San Francisco Airport (SFO)?
San Francisco Airport (SFO) hosts 5 major car rental companies, with daily rates averaging $63 for economy cars. Top options include:

• Europcar
• Thrifty
• Dollar
• Hertz
• Fox
Which airports can I use when flying from Knoxville to San Francisco?
Flights from Knoxville to San Francisco usually depart from Knoxville McGhee Tyson (TYS) and arrive at San Francisco (SFO).
Which airports do connecting flights from Knoxville to San Francisco pass through?
One-stop flights from Knoxville to San Francisco most commonly connect through:

• Dallas/Fort Worth (DFW) - 37% of one-stop connections
• Atlanta Hartsfield-Jackson (ATL) - 25% of one-stop connections
• Denver Intl (DEN) - 21% of one-stop connections
• Charlotte Douglas (CLT) - 7% of one-stop connections
Can I save money by using flexible dates for flights from Knoxville to San Francisco?
Yes. Flexible dates can save you up to 34% on flights from Knoxville to San Francisco. Thursday is the cheapest departure day at $377 round-trip on average, while Sunday is the most expensive at $566, a difference of $189.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
How much time can I save by choosing a different layover airport from Knoxville to San Francisco?
Flying via Dallas/Fort Worth (DFW) gives the shortest average 1-stop total travel time at 7h 29m, compared with 7h 29m via Atlanta Hartsfield-Jackson (ATL) and 7h 44m via Chicago O'Hare Intl (ORD).
What is the time difference between Knoxville and San Francisco?
San Francisco is 3 hours behind Knoxville (Pacific Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.
What popular places can I visit in San Francisco?
Some of the most popular sights in San Francisco are Fisherman's Wharf, Union Square and Moscone Center. These are among the most viewed places in San Francisco on KAYAK.

If your dates are flexible, aim for a Thursday departure and avoid flying on Sunday. On this route, Thursday flights average $377, about $189 less than Sunday fares (33% savings) based on the last 12 months.
For the best chance at a low fare, aim to book around 19 weeks before you fly. On this route, that window historically saves about 41% versus last-minute pricing (KAYAK booking data, last 12 months).
If you can choose when to travel, plan your Knoxville to San Francisco trip for February. Fares historically average $329 round-trip in that month - typically $329 less than the most expensive month, which is May (based on the last 12 months).
If you're arriving late at night and need somewhere to stay, check out these hotels close to San Francisco Airport.

• Grand Hyatt At Sfo

More options for your flight from Knoxville to San Francisco

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TYS - SFO

$189 Find Cheap Flights from Knoxville to San Francisco - Compare and Save

Everything you should know

Cheap Flights from Knoxville to San Francisco (TYS-SFO)

Recent round-trip flight deals from Knoxville to San Francisco

Recent one-way flight deals from Knoxville to San Francisco

Recent last minute flight deals from Knoxville to San Francisco

Price, demand and travel trends for Knoxville to San Francisco flights

What's the cheapest day of the week to fly from Knoxville to San Francisco?

What’s the cheapest month to fly from Knoxville to San Francisco?

When are flights from Knoxville to San Francisco the cheapest?

Which airline is the cheapest to fly from Knoxville to San Francisco?

What’s the most popular layover airport when flying from Knoxville to San Francisco?

What is the cheapest layover airport when flying from Knoxville to San Francisco?

When flying from Knoxville to San Francisco which airport offers the shortest layover?

Key details for Knoxville to San Francisco flights

Low season

High season

Cheapest flight

When to book flights from Knoxville to San Francisco

Your Knoxville to San Francisco flight questions, answered

Your guide to booking Knoxville to San Francisco flights

More options for your flight from Knoxville to San Francisco

Complete your trip to San Francisco with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Knoxville to San Francisco

Find direct flights to and from Knoxville and San Francisco

Flights from domestic origins to San Francisco

Flights to other popular destinations

Find deals for your return flight