TYS - SFO

$126 Find Cheap Flights from Knoxville to San Francisco - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$266
Typical prices: $351-$582
Multiple Airlines
Fri 10/26Wed 10/31
TYS - SFO • 1 stop
Cheapest one-way
$126
Typical prices: $220-$395
Multiple Airlines
Fri 10/19
TYS - SFO • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Knoxville and San Francisco. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to book
19 weeks
in advance
Our data shows that travelers who book at least 19 weeks in advance save around 38% compared to booking last minute.
Insights
Insights
When to travel
February
Cheapest • 29% price drop
July
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Minneapolis St Paul (MSP)
Cheapest • Avg $246 (round-trip)
Dallas/Fort Worth (DFW)
Shortest trip • 7h 30m (one-way)
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Insights
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We hope you love your trip to San Francisco!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to San Francisco (TYS-SFO)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to San Francisco

Mon, Oct 26 - Sat, Oct 31
Multiple Airlines Logo
9:42 pm - 8:19 amTYS  Knoxville McGhee Tyson-SFO San Francisco
13h 37m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
12:20 pm - 2:11 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
22h 51m1 stop Denver Intl
$266Multiple Airlines
Mon, Oct 26 - Fri, Oct 30
Multiple Airlines Logo
9:42 pm - 8:19 amTYS  Knoxville McGhee Tyson-SFO San Francisco
13h 37m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
10:23 pm - 2:11 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
36h 48m2 stops Las Vegas Harry Reid Intl Denver Intl
$267Multiple Airlines
Mon, Oct 26 - Fri, Oct 30
Multiple Airlines Logo
9:42 pm - 8:19 amTYS  Knoxville McGhee Tyson-SFO San Francisco
13h 37m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
11:06 am - 9:49 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 43m1 stop Las Vegas Harry Reid Intl
$272Multiple Airlines
Tue, Oct 20 - Tue, Oct 27
American Airlines Logo
5:26 pm - 11:57 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
9h 31m1 stop Dallas/Fort Worth
American Airlines Logo
10:03 pm - 8:32 amSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 29m1 stop Charlotte Douglas
$377American Airlines
Thu, Oct 15 - Mon, Oct 19
American Airlines Logo
8:02 pm - 12:44 amTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 42m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 4:36 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 06m1 stop Dallas/Fort Worth
$377American Airlines
Thu, Oct 15 - Mon, Oct 19
Delta Logo
6:23 pm - 11:56 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
8h 33m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:25 pm - 9:34 amSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 09m1 stop Atlanta Hartsfield-Jackson
$377Delta
Thu, Oct 15 - Sat, Oct 17
Delta Logo
6:23 pm - 11:56 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
8h 33m1 stop Atlanta Hartsfield-Jackson
Delta Logo
10:25 pm - 9:34 amSFO  San Francisco-TYS Knoxville McGhee Tyson
8h 09m1 stop Atlanta Hartsfield-Jackson
$377Delta
Sat, Nov 7 - Tue, Nov 10
American Airlines Logo
5:19 pm - 10:09 pmTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 50m1 stop Charlotte Douglas
American Airlines Logo
12:39 pm - 11:32 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 53m1 stop Dallas/Fort Worth
$377American Airlines
Tue, Oct 13 - Tue, Oct 20
United Airlines Logo
6:00 am - 10:30 amTYS  Knoxville McGhee Tyson-SFO San Francisco
7h 30m1 stop Chicago O'Hare Intl
United Airlines Logo
5:00 am - 3:49 pmSFO  San Francisco-TYS Knoxville McGhee Tyson
7h 49m1 stop Denver Intl
$380United Airlines
Wed, Nov 25 - Wed, Nov 25
United Airlines Logo
5:45 am - 11:22 amTYS  Knoxville McGhee Tyson-SFO San Francisco
8h 37m1 stop Washington, D.C. Dulles Intl
United Airlines Logo
8:45 pm - 9:53 amSFO  San Francisco-TYS Knoxville McGhee Tyson
10h 08m1 stop Chicago O'Hare Intl
$415United Airlines
Booking Insights

Price, demand and travel trends for Knoxville to San Francisco flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What's the cheapest day of the week to fly from Knoxville to San Francisco?

Based on deals KAYAK users found in the last 12 months, Thursday is the cheapest day of the week to fly from Knoxville to San Francisco. It’s 17% cheaper than the average day, while Sunday is the most expensive, with prices 26% higher.

What’s the cheapest month to fly from Knoxville to San Francisco?

•February is the cheapest month to fly from Knoxville to San Francisco at $329 round-trip.
•May ($658) and June ($626) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 100% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

When are flights from Knoxville to San Francisco the cheapest?

Flights from Knoxville to San Francisco are cheapest 19 weeks before departure. Booking in this window typically costs about 38% less than the average last-minute fare (within 2 weeks of the flight), based on KAYAK data.

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Key details for Knoxville to San Francisco flights

Low season

April

Cheapest flight

$126
Beat the crowds with an average 58% drop in travelers.
The most popular month to fly with an average 56% increase in travelers.
One-way flight from Knoxville to San Francisco

When to book flights from Knoxville to San Francisco

Are your dates flexible? Find out the best times to travel from Knoxville to San Francisco based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Knoxville to San Francisco flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Knoxville to San Francisco?

    Two cabin classes are available on flights from Knoxville to San Francisco:

    • Economy Class
    • First Class

  • How long is a flight from Knoxville to San Francisco?

    A nonstop flight from Knoxville to San Francisco takes 00m, covering 2,114 miles.

  • Do I need a passport to fly from Knoxville to San Francisco?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Knoxville to San Francisco flight?

    Round-trip flights from Knoxville to San Francisco range from $351 to $582, with an average of $463 over the past 12 months. Anything below $351 counts as a good deal.

  • How expensive are last-minute Knoxville to San Francisco flights?

    Last-minute fares on this route (booked within two weeks of departure) run 23% above the $463 route average. Book 19 weeks before departure for the lowest fares.

  • Have flight prices from Knoxville to San Francisco changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $266 to $1,945. That means the highest observed fare was about 7x higher than the lowest one.

  • How are flight prices from Knoxville to San Francisco looking right now?

    One-way fares from Knoxville to San Francisco are currently lower than usual. Average one-way flight prices are about $179, which is 42% below the typical average for this route.

  • What car rental options are available at San Francisco Airport (SFO)?

    San Francisco Airport (SFO) hosts 5 major car rental companies, with daily rates starting from around $15 for economy cars. Top options include:

    • Thrifty
    • Europcar
    • Dollar
    • Hertz
    • Fox

  • Which airports can I use when flying from Knoxville to San Francisco?

    Flights from Knoxville to San Francisco usually depart from Knoxville McGhee Tyson (TYS) and arrive at San Francisco (SFO).

  • Which airports do connecting flights from Knoxville to San Francisco pass through?

    One-stop flights from Knoxville to San Francisco most commonly connect through:

    • Dallas/Fort Worth (DFW) - 38% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 23% of one-stop connections
    • Denver Intl (DEN) - 22% of one-stop connections
    • Charlotte Douglas (CLT) - 7% of one-stop connections

  • Can I save money by using flexible dates for flights from Knoxville to San Francisco?

    Yes. Flexible dates can save you up to 34% on flights from Knoxville to San Francisco. Thursday is the cheapest departure day at $388 round-trip on average, while Sunday is the most expensive at $586, a difference of $198.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Knoxville to San Francisco?

    Flying via Dallas/Fort Worth (DFW) gives the shortest average 1-stop total travel time at 7h 30m, compared with 7h 31m via Atlanta Hartsfield-Jackson (ATL) and 7h 44m via Chicago O'Hare Intl (ORD).

  • What is the time difference between Knoxville and San Francisco?

    San Francisco is 3 hours behind Knoxville (Pacific Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in San Francisco?

    Some of the most popular sights in San Francisco are Fisherman's Wharf, Union Square and Moscone Center. These are among the most viewed places in San Francisco on KAYAK.

Your guide to booking Knoxville to San Francisco flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Thursday departure and avoid flying on Sunday. On this route, Thursday flights average $388, about $198 less than Sunday fares (34% savings) based on the last 12 months.
  • For the best chance at a low fare, aim to book around 19 weeks before you fly. On this route, that window historically saves about 38% versus last-minute pricing (KAYAK booking data, last 12 months).
  • If you can choose when to travel, plan your Knoxville to San Francisco trip for February. Fares historically average $329 round-trip in that month - typically $329 less than the most expensive month, which is May (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to San Francisco Airport.

    • Grand Hyatt At Sfo

More options for your flight from Knoxville to San Francisco

Complete your trip to San Francisco with a hotel stay or car rental

Car rentals in San Francisco
Hotels in San Francisco
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