SFO - TYS

$131 Find Cheap Flights from San Francisco to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to Knoxville departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Francisco to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from San Francisco to Knoxville, as well as popular online travel agencies
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41,299,237 searches in the past 7 days on KAYAK

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Everything you should know

Cheapest round-trip
$218
Overall average: $532
Frontier
Sun 5/3Mon 5/11
SFO - TYS • 1 stop
Cheapest one-way
$131
Typical prices: $180-$359
Multiple Airlines
Wed 4/15
SFO - TYS • 2 stops
Top airlines
Cheapest • from $218 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
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Airline reviews
Airline reviews
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Nonstop flights
Not available
There are currently no direct flights between San Francisco and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $434 (round-trip)
Shortest trip • 6h 56m (one-way)
Insights
Insights
Insights
Insights
When to book
in advance
Our data shows that travelers who book at least 3 weeks in advance save around 23% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
Cheapest • 19% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from San Francisco to Knoxville (SFO-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to Knoxville

Sun, May 3 - Mon, May 11
Frontier Logo
6:00 am - 3:33 pm
SFO
-
TYS
6h 33m
1 stop
Frontier Logo
8:32 pm - 11:42 am
TYS
-
SFO
18h 10m
1 stop
$218Frontier
Thu, May 28 - Mon, Jun 1
Frontier Logo
12:52 pm - 7:33 pm
SFO
-
TYS
27h 41m
1 stop
Frontier Logo
8:32 pm - 11:42 am
TYS
-
SFO
18h 10m
1 stop
$280Frontier
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
11:49 pm - 10:26 am
SFO
-
TYS
7h 37m
1 stop
American Airlines Logo
7:00 am - 12:32 pm
TYS
-
SFO
8h 32m
1 stop
$359American Airlines
Sat, May 2 - Fri, May 15
Multiple Airlines Logo
6:00 am - 3:33 pm
SFO
-
TYS
30h 33m
1 stop
Multiple Airlines Logo
1:15 pm - 11:42 am
TYS
-
SFO
25h 27m
2 stops
$366Multiple Airlines
Fri, Apr 24 - Sat, May 9
American Airlines Logo
11:49 pm - 10:26 am
SFO
-
TYS
7h 37m
1 stop
American Airlines Logo
3:58 pm - 9:28 pm
TYS
-
SFO
8h 30m
1 stop
$369American Airlines
Sat, May 2 - Fri, May 15
Multiple Airlines Logo
6:00 am - 3:33 pm
SFO
-
TYS
30h 33m
1 stop
Multiple Airlines Logo
1:43 pm - 10:41 am
TYS
-
SFO
23h 58m
1 stop
$371Multiple Airlines
Fri, Apr 24 - Tue, Apr 28
American Airlines Logo
11:49 pm - 12:30 pm
SFO
-
TYS
9h 41m
1 stop
American Airlines Logo
4:09 pm - 10:04 pm
TYS
-
SFO
8h 55m
1 stop
$379American Airlines
Mon, May 4 - Fri, May 15
Multiple Airlines Logo
11:26 pm - 10:36 am
SFO
-
TYS
32h 10m
2 stops
Multiple Airlines Logo
1:43 pm - 10:41 am
TYS
-
SFO
23h 58m
1 stop
$382Multiple Airlines
Tue, Apr 14 - Tue, Apr 21
Southwest Logo
5:25 am - 7:40 pm
SFO
-
TYS
11h 15m
2 stops
Southwest Logo
8:15 am - 7:55 pm
TYS
-
SFO
14h 40m
2 stops
$385Southwest
Sun, Apr 26 - Sat, May 2
American Airlines Logo
11:59 pm - 12:30 pm
SFO
-
TYS
9h 31m
1 stop
American Airlines Logo
4:09 pm - 10:00 pm
TYS
-
SFO
8h 51m
1 stop
$389American Airlines
Booking Insights

KAYAK's insights & trends for San Francisco to Knoxville flights

Get data-powered insights and trends into flights from San Francisco to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Francisco to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to Knoxville is August, where tickets cost $383 (return) on average. On the other hand, the most expensive months are November and April, where the average cost of round-trip tickets is $573 and $534 respectively.

How far in advance should I book a flight from San Francisco to Knoxville?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to Knoxville, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to Knoxville, you should book around 3 weeks before departure, which saves you about 23% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 22 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$131
Best time to beat the crowds with an average 9% drop in price.
Most popular time to fly with an average 9% increase in price.
Flight from San Francisco to Knoxville

When to book flights from San Francisco to Knoxville

Are your dates flexible? Find out the best times to travel from San Francisco to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from San Francisco to Knoxville

  • What are the transportation options to get from the McGhee Tyson Airport (TYS) to downtown Knoxville?

    Since there are no public transportation options that offer service from the airport to the downtown area, the best choice for most travelers is to take one of the readily available taxis outside of the terminal building that will make the trip in about 18min.

  • Where should I be looking for my rental car company when I arrive at the airport in Knoxville?

    There are roughly 8 different rental car companies that operate at this airport, and every one of them has a customer service counter on the lower level of the airport terminal building adjacent to the baggage claim area. All vehicles for rent sit just outside of the exit doors from the baggage claim area in the adjacent parking lots.

  • Where should I plan on meeting my rideshare ride after my flight to Knoxville?

    All rideshare companies do their pick-ups on the lower level of the terminal building just outside of the baggage claim area. When you exit the baggage claim area of the terminal building, you will see signage for pick-up locations just to the right.

  • Are there any hotels that have a convenient location close to the terminal buildings at the airport in Knoxville?

    One of the most convenient choices is Hilton Knoxville Airport, which has a location right on the airport property. When you walk out of the terminal building, you will see this hotel just a few steps from the terminal building to your right just before the Economy Parking Lot B.

  • What is the cheapest flight from San Francisco to Knoxville?

    In the last 3 days, the lowest price for a flight from San Francisco to Knoxville was $131 for a one-way ticket and $218 for a round-trip.

  • Do I need a passport to fly between San Francisco and Knoxville?

    No

  • Which airports will I be using when flying from San Francisco to Knoxville?

    San Francisco airport is called San Francisco and the only airport in Knoxville is Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from San Francisco to Knoxville?

    The Embraer 175 is the aircraft model that flies most regularly on the San Francisco to Knoxville flight route.

  • Which airline alliances offer flights from San Francisco to Knoxville?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between San Francisco and Knoxville, with Star Alliance being the most commonly used for this route.

  • What is the most popular layover when flying to Knoxville from San Francisco?

    Dallas is the most popular layover city among KAYAK users traveling from San Francisco to Knoxville.

  • Which is the best airline for flights from San Francisco to Knoxville, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from San Francisco to Knoxville are Delta and United Airlines. With an average price for the route of $422 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $550 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from San Francisco to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from San Francisco is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to San Francisco with another airline. Booking your flights between San Francisco and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from San Francisco up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from San Francisco to Knoxville

  • A fantastic way to get to the San Francisco International Airport (SFO) from the downtown area without having to drive your own car is to take the BART Yellow Line light rail train that can make the trip from the downtown area to the airport in 29 minutes.
  • If you plan on getting dropped off at the San Francisco International Airport before your flight, a good choice for a drop-off point is the Kiss and Fly location adjacent to the rental car center at the airport. This allows passengers to take their time getting dropped off, and then they can ride aboard the AirTrain Blue Line to the terminal building from the rental car center.
  • Parents who plan on taking their kids through the San Francisco International Airport before a flight to Knoxville should know that the airport offers an interactive play area in terminal two that lets kids have some fun and expend some energy before a long flight.
  • Travelers making their way to Knoxville with a pet or a service animal should know that the San Francisco International Airport offers seven different pet relief areas both outside and inside the terminal buildings at the airport. All of the relief areas have things like drinking bowls and waste gloves with disposal areas.
  • If you plan on flying to Knoxville from the San Francisco International Airport and want a comfortable place to wait for your flight, the San Francisco International Airport offers airline lounges from United Airlines, Alaska Airlines, Delta Airlines, and American Airlines that all offer plenty of comfortable seating options as well as a wide selection of food and beverage choices.

Reviews of the top 4 airlines serving from San Francisco to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from San Francisco to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from San Francisco to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8286 reviews
7.2Food
7.9Comfort
8.5Crew
8.1Boarding
7.8Entertainment
Airline reviews

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

2.0 MediocreIsabella, Mar 2026
SJC - SLC
Read more Delta reviews

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Same experience as the flight from Norfolk to Atlanta where people are boarded in zones that don't make sense. People behind you on the plane will get on before you and they take the luggage space on your row.

Flight was delayed by 3-hours and their fix was… complimentary pretzels.

The crew, and fellow passengers, were super gracious and kind. There seemed to be plenty of bin space even though the plane was full. It’s nice to get a glass of wine with dinner in Premiere seating, and there was a lot of food.

Everything I mentioned earlier - the airbus was more comfortable indeed and the experience was further enhanced.

Smallest leg room I've ever had on a plane.

The plane was an older model, so it wasn’t as comfortable as others. The flight attendants were not helpful during onboarding. It was a full flight so there was chaos finding space for baggage.

Awesome! On time flight, early arrival, and a complimentary upgrade!

Delta One is extraordinary. I fly business when somebody hires me. I just wonder why there is such a chasm between business class and the insanely inhumane and nonsensical coach. The seats are not large enough to fit even my tiny wife. We fly 10% of what we did because we don’t want to pay 5-10 k but for $400 it’s unbearable. It seems like the accountants took over and made stupid decisions. Screw in 20 extra seats and make it so unbearable that people fly 90% less. Just put the damn price up and put some proper chairs in. But business, yay.

Delta’s staff is unmatched. From the gate agents, to the pilots, to the flight attendants… all top of the industry.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

The flight was delayed so we were dead tired, and after that the turbulence was horrible. I was very scared.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Flight delayed for more than 16 hrs and no effort was spent to provide an alternate

it was a very short flight so my expectations were low.

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Terrible. No customer service, no food, no drinks on a 6 hour premier economy booking.

The flight crew where really good. Better then the crew from BNE to SFO

left on time, reasonable boarding process arrived early luggage came out quickly

Pushed back only to get deplaned due to a tire damaged by ground crew. They did at least go pretty fast. The bathrooms should be banned under the Geneva convention. No room to even sit straight on the toilet. The under-seat entertainment units block what little leg room there is.

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

Dloght delayed by 2.5 hrs . Common theme in my last four american floghts

They are rarely on time! Very hard to plan your travels when flights or connections keep getting delayed.

My seat was assigned last row behind restrooms No legroom’s I’m very Pettit Still was not comfortable Food choice was excellent

The worst Airline ever. They centered my second flight and leave me in NY. They don’t have any representatives at the airport and they don’t respond to calls. Basically I got stuck. I will never purchase through there again.

The chicken wrap was tiny ($13 for what looked like a 1/3 of a normal wrap?) and disgusting.

Mediocre would be best description. Food bland. Seat biz class uncomfortable to sleep. Crew never dimmed lights completely in an overnight flight to Europe. Would avoid AA if possible.

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Arrived early picked up my bag in a few minutes- great trip - thank you

Massimo, flight attendant was very authentic, attentive - wonderful. Food/wrap was just okay.

My flight was originally from SAT to MCO connecting from MCO to ORD. We got diverted to ATL and than Frontier staff there was sooo un helpful first they said they couldn’t give us any accommodation since our flight first got delayed that cancelled and now it’s 221am and I am still in ATL since they said they need to create a new flight my final destination is ORD and I have been delayed twice and cancelled. With no real help the frontier app didn’t work no email updates over all such a horrible experience

There's no seats that lean back with little leg space i wad uncomfortable the entire flight. Your charges for extra baggage is despicable and costly!!

Remind customers of the need to have passport or new ID for boarding.

Flight was canceled. Most upsetting was message from Kayak, stating that the flight was canceled and click with Kayak for details regarding rebook, refund details. THERE'S NO INFORMATION PROVIDED BY KAYAK EXCEPT THAT FLIGHT IS CANCELED. AND NOW THIS SURVEY TO FIND OUT HOW WAS THE FLIGHT !!!!!!!

The flight never took off and we spent 7 hours at the airport

Gate not determined until I got to the airport - hard to plan the trip to the airport.

Our flight was canceled. I will never use Kayak nor Frontier for travel again. The entire experience was a headache.

It was ok. It was expensive to check 2 bags ($75.00 per bag), and then it took a long time to wait for shuttle to take us from one terminal to the terminal where the plane was taking off at LAX. And all of this for a flight where we had to pay for any food or drink that was not water.

When I wanted to check in 3 hours prior to boarding time, the employees mentioned “a little over an hour delay” so I waited for an hour then I went to go look for food in the terminal and most people from that flight were in the same area looking for food. Finally I decided after food to check to see if it’s anytime closer and now it’s 2 mins until boarding closes?! What are you kidding me? I didn’t receive anything via sms about boarding now nor via email or on the intercom. I luckily made it through, barely, and then there’s no room for my carry on mind you I’m in the very first row so I had to place my purse in one further row back and my carry on sections down. Not sure who pays for better seats to get your stuff placed all over the plane but that was the worst experience I’ve ever had flying with anyone.

This airline sucks. They offer low rates then charge you for everything, the app does not work well, the seats are the most uncomfortable. Maintenance issues on the flight, and you still have to sit through their credit card commercials. People are nice enough but does not make up for overall poor experience.

Everything you need to know for your flight from San Francisco to Knoxville

Information on your arrival and departure airports