LSE - SDF

$446 Find Cheap Flights from La Crosse to Louisville - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$446
Typical prices: $408-$491
American Airlines
Wed 11/21Sat 11/24
LSE - SDF • 1 stop
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Booking Insights
Flight Deals

Cheap Flights from La Crosse to Louisville (LSE-SDF)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from La Crosse to Louisville

Sat, Nov 21 - Tue, Nov 24
American Airlines Logo
6:01 am - 9:37 pmLSE  La Crosse-SDF Louisville Intl
14h 36m1 stop Chicago O'Hare Intl
American Airlines Logo
6:24 am - 6:20 pmSDF  Louisville Intl-LSE La Crosse
12h 56m1 stop Chicago O'Hare Intl
$446American Airlines
Wed, Nov 25 - Sun, Nov 29
American Airlines Logo
6:50 pm - 4:01 pmLSE  La Crosse-SDF Louisville Intl
20h 11m1 stop Chicago O'Hare Intl
American Airlines Logo
1:14 pm - 6:20 pmSDF  Louisville Intl-LSE La Crosse
6h 06m1 stop Chicago O'Hare Intl
$494American Airlines
Wed, Nov 25 - Sun, Nov 29
American Airlines Logo
6:50 pm - 4:01 pmLSE  La Crosse-SDF Louisville Intl
20h 11m1 stop Chicago O'Hare Intl
American Airlines Logo
1:14 pm - 6:20 pmSDF  Louisville Intl-LSE La Crosse
6h 06m1 stop Chicago O'Hare Intl
$499American Airlines
Wed, Nov 25 - Sun, Nov 29
American Airlines Logo
6:50 pm - 12:43 pmLSE  La Crosse-SDF Louisville Intl
16h 53m1 stop Chicago O'Hare Intl
American Airlines Logo
6:24 am - 11:56 amSDF  Louisville Intl-LSE La Crosse
6h 32m1 stop Chicago O'Hare Intl
$513American Airlines
Mon, Mar 29 - Sun, Apr 4
American Airlines Logo
5:32 am - 12:44 pmLSE  La Crosse-SDF Louisville Intl
6h 12m1 stop Chicago O'Hare Intl
American Airlines Logo
6:14 pm - 12:23 amSDF  Louisville Intl-LSE La Crosse
7h 09m1 stop Chicago O'Hare Intl
$542American Airlines
Sat, Nov 21 - Tue, Nov 24
American Airlines Logo
6:01 am - 9:37 pmLSE  La Crosse-SDF Louisville Intl
14h 36m1 stop Chicago O'Hare Intl
American Airlines Logo
6:02 am - 6:20 pmSDF  Louisville Intl-LSE La Crosse
13h 18m2 stops Washington, D.C. Reagan-National Chicago O'Hare Intl
$574American Airlines
Fri, Nov 13 - Tue, Nov 17
American Airlines Logo
12:24 pm - 5:13 pmLSE  La Crosse-SDF Louisville Intl
3h 49m1 stop Chicago O'Hare Intl
American Airlines Logo
6:27 am - 11:53 amSDF  Louisville Intl-LSE La Crosse
6h 26m1 stop Chicago O'Hare Intl
$624American Airlines
Tue, Nov 10 - Sat, Nov 14
American Airlines Logo
5:57 am - 12:43 pmLSE  La Crosse-SDF Louisville Intl
5h 46m1 stop Chicago O'Hare Intl
American Airlines Logo
1:32 pm - 6:16 pmSDF  Louisville Intl-LSE La Crosse
5h 44m1 stop Chicago O'Hare Intl
$640American Airlines
Wed, Nov 25 - Sun, Nov 29
American Airlines Logo
6:01 am - 6:08 pmLSE  La Crosse-SDF Louisville Intl
11h 07m2 stops Chicago O'Hare Intl Dallas/Fort Worth
American Airlines Logo
6:24 am - 11:56 amSDF  Louisville Intl-LSE La Crosse
6h 32m1 stop Chicago O'Hare Intl
$670American Airlines
Fri, Apr 9 - Sun, Apr 11
American Airlines Logo
10:05 am - 10:08 pmLSE  La Crosse-SDF Louisville Intl
11h 03m2 stops Chicago O'Hare Intl Charlotte Douglas
American Airlines Logo
6:00 am - 9:35 amSDF  Louisville Intl-LSE La Crosse
4h 35m1 stop Chicago O'Hare Intl
$714American Airlines
Booking Insights

Price, demand and travel trends for La Crosse to Louisville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from La Crosse to Louisville?

Round-trip flights from La Crosse to Louisville typically range from $408 to $491. The lowest price found in the past 5 days was $446, on American Airlines.

Key details for La Crosse to Louisville flights

Cheapest flight

$446
Round-trip flight from La Crosse to Louisville

When to book flights from La Crosse to Louisville

Are your dates flexible? Find out the best times to travel from La Crosse to Louisville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your La Crosse to Louisville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from La Crosse to Louisville?

    Only Economy Class is available on flights from La Crosse to Louisville.

  • Do I need a passport to fly from La Crosse to Louisville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • Have flight prices from La Crosse to Louisville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $446 to $921. That means the highest observed fare was about 2x higher than the lowest one.

  • What car rental options are available at Louisville Intl Airport (SDF)?

    Louisville Intl Airport (SDF) hosts 5 major car rental companies, with daily rates averaging $75 for economy cars. Top options include:

    • Hertz
    • Dollar
    • Alamo
    • Thrifty
    • Budget

  • Which airports can I use when flying from La Crosse to Louisville?

    Flights from La Crosse to Louisville usually depart from La Crosse (LSE) and arrive at Louisville Intl (SDF).

  • Which airports do connecting flights from La Crosse to Louisville pass through?

    Most connecting flights from La Crosse to Louisville pass through Chicago O'Hare Intl (ORD), which handles 100% of one-stop traffic on this route.

  • Can I save money by using flexible dates for flights from La Crosse to Louisville?

    Yes. Flexible dates can save you up to 17% on flights from La Crosse to Louisville. Tuesday is the cheapest departure day at $408 round-trip on average, while Wednesday is the most expensive at $491, a difference of $83.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What is the time difference between La Crosse and Louisville?

    Louisville is 1 hour ahead of La Crosse (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Louisville?

    Some of the most popular sights in Louisville are Louisville Waterfront Park and Masonic Widows and Orphans Home. These are among the most viewed places in Louisville on KAYAK.

Your guide to booking La Crosse to Louisville flights

Get tips on when to book, when to fly and what to know before your trip.

More options for your flight from La Crosse to Louisville

Complete your trip to Louisville with a hotel stay or car rental