LSE - SFO

$302 Find Cheap Flights from La Crosse to San Francisco - Compare and Save

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from La Crosse to San Francisco departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$302
Multiple Airlines
Mon 8/31Thu 9/3
LSE - SFO • 2 stops
Nonstop flights
Not available
There are currently no direct flights between La Crosse and San Francisco. You'll need at least 1 connection.
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Top layover airports
Cheapest • Avg $368 (round-trip)
Shortest trip • 6h 40m (one-way)
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Booking Insights
Flight Deals

Cheap Flights from La Crosse to San Francisco (LSE-SFO)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from La Crosse to San Francisco that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from La Crosse to San Francisco

Mon, Aug 31 - Thu, Sep 3
Multiple Airlines Logo
1:56 pm - 11:52 amLSE  La Crosse-SFO San Francisco
23h 56m2 stops Phoenix-Mesa Gateway San Diego
Multiple Airlines Logo
7:04 pm - 11:46 amSFO  San Francisco-LSE La Crosse
14h 42m1 stop Phoenix Sky Harbor Intl
$302Multiple Airlines
Thu, Oct 1 - Thu, Oct 8
Multiple Airlines Logo
9:46 am - 7:48 pmLSE  La Crosse-SFO San Francisco
36h 02m2 stops Orlando Sanford Intl Atlanta Hartsfield-Jackson
Multiple Airlines Logo
10:06 pm - 7:16 pmSFO  San Francisco-LSE La Crosse
19h 10m1 stop Phoenix Sky Harbor Intl
$361Multiple Airlines
Wed, Oct 14 - Mon, Oct 19
American Airlines Logo
6:50 pm - 11:59 pmLSE  La Crosse-SFO San Francisco
7h 09m1 stop Chicago O'Hare Intl
American Airlines Logo
3:18 pm - 11:59 pmSFO  San Francisco-LSE La Crosse
6h 41m1 stop Chicago O'Hare Intl
$474American Airlines
Wed, Nov 18 - Sun, Nov 22
American Airlines Logo
12:22 pm - 8:00 pmLSE  La Crosse-SFO San Francisco
9h 38m1 stop Chicago O'Hare Intl
American Airlines Logo
7:11 am - 6:23 pmSFO  San Francisco-LSE La Crosse
9h 12m1 stop Chicago O'Hare Intl
$520American Airlines
Thu, Oct 1 - Thu, Oct 8
American Airlines Logo
5:22 pm - 11:29 amLSE  La Crosse-SFO San Francisco
20h 07m1 stop Chicago O'Hare Intl
American Airlines Logo
5:27 pm - 11:53 amSFO  San Francisco-LSE La Crosse
16h 26m1 stop Chicago O'Hare Intl
$524American Airlines
Wed, Oct 14 - Mon, Oct 19
American Airlines Logo
12:23 pm - 11:37 pmLSE  La Crosse-SFO San Francisco
13h 14m2 stops Chicago O'Hare Intl Los Angeles Los Angeles
American Airlines Logo
5:27 pm - 11:53 amSFO  San Francisco-LSE La Crosse
16h 26m1 stop Chicago O'Hare Intl
$530American Airlines
Mon, Aug 31 - Fri, Sep 4
American Airlines Logo
12:19 pm - 11:45 pmLSE  La Crosse-SFO San Francisco
13h 26m1 stop Chicago O'Hare Intl
American Airlines Logo
11:30 pm - 2:42 pmSFO  San Francisco-LSE La Crosse
13h 12m2 stops Dallas/Fort Worth Chicago O'Hare Intl
$530American Airlines
Thu, Jan 14 - Sun, Jan 17
American Airlines Logo
12:23 pm - 8:11 pmLSE  La Crosse-SFO San Francisco
9h 48m1 stop Chicago O'Hare Intl
American Airlines Logo
7:10 am - 6:20 pmSFO  San Francisco-LSE La Crosse
9h 10m1 stop Chicago O'Hare Intl
$538American Airlines
Fri, Sep 4 - Sun, Sep 13
American Airlines Logo
12:19 pm - 6:00 pmLSE  La Crosse-SFO San Francisco
7h 41m1 stop Chicago O'Hare Intl
American Airlines Logo
2:58 pm - 12:20 amSFO  San Francisco-LSE La Crosse
7h 22m1 stop Chicago O'Hare Intl
$538American Airlines
Fri, Sep 4 - Sun, Sep 13
American Airlines Logo
5:20 pm - 12:28 pmLSE  La Crosse-SFO San Francisco
21h 08m1 stop Chicago O'Hare Intl
American Airlines Logo
7:00 am - 12:20 amSFO  San Francisco-LSE La Crosse
15h 20m1 stop Chicago O'Hare Intl
$554American Airlines
Booking Insights

KAYAK's insights & trends for La Crosse to San Francisco flights

Get data-powered insights and trends into flights from La Crosse to San Francisco to help you find the cheapest flights, the best time to fly and much more.

What is the most popular layover airport when flying from La Crosse to San Francisco?

Percentage of 1-stop round-trip flights from La Crosse to San Francisco chosen by KAYAK users via each layover airport in the last 12 months (only includes trips with the same layover airport on both legs).

Chicago (ORD) is the top choice – 92% of KAYAK users who clicked on 1-stop flights from La Crosse to San Francisco picked an itinerary connecting there.

What is the cheapest layover airport when flying from La Crosse to San Francisco?

Average round-trip price for 1-stop flights from La Crosse to San Francisco clicked by KAYAK users in the last 12 months (only includes trips with the same layover airport on both legs).

Flights via Minneapolis (MSP) offer the most affordable fares, with an average round-trip price of $368.

Which layover airport offers the shortest total travel time from La Crosse to San Francisco?

Shortest average total travel time for 1-stop one-way flights from La Crosse to San Francisco via different layover airports, based on KAYAK user data from the last 12 months.

Consider flying via Minneapolis (MSP) for the shortest journey. The average one-way travel time for flights connecting there is 6h 40m.

Which layover airport has the quickest connection when flying from La Crosse to San Francisco?

Average layover duration at different layover airports for 1-stop one-way flights from La Crosse to San Francisco, based on KAYAK user data from the last 12 months.

If you prefer a quick connection, Chicago (ORD) often has the shortest layovers from La Crosse to San Francisco, with an average of 1h 47m.

Good to know

Cheapest flight

$302
Flight from La Crosse to San Francisco

When to book flights from La Crosse to San Francisco

Are your dates flexible? Find out the best times to travel from La Crosse to San Francisco based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from La Crosse to San Francisco

  • What is the cheapest flight from La Crosse to San Francisco?

    In the last 5 days, the lowest price for a flight from La Crosse to San Francisco was $302 for a round-trip ticket.

  • Do I need a passport to fly between La Crosse and San Francisco?

    No, a passport isn't needed to fly from La Crosse to San Francisco. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from La Crosse to San Francisco?

    On your way to San Francisco, you’ll fly out from La Crosse. You’ll be landing at San Francisco.

  • Which aircraft models fly most regularly from La Crosse to San Francisco?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from La Crosse to San Francisco?

    oneworld is the only airline alliance operating flights between La Crosse and San Francisco.

  • How does KAYAK find such low prices on flights from La Crosse to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from La Crosse to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from La Crosse to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco from La Crosse is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from La Crosse to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back to La Crosse with another airline. Booking your flights between La Crosse and SFO can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from La Crosse to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco from La Crosse up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from La Crosse to San Francisco

 
See real verified KAYAK customer reviews for airlines flying from La Crosse to San Francisco. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from La Crosse to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11895 reviews
7.2Comfort
7.9Crew
6.4Food
6.8Entertainment
7.5Boarding
Airline reviews

Our experience with American Airlines was extremely disappointing and honestly made an already exhausting international journey much worse. After flying all the way from Melbourne and dealing with significant jet lag, the American Airlines experience at LAX was the last thing we needed. The terminal and boarding area felt very old and uncomfortable, with little to no air conditioning and only old fans running in the area. Boarding was also through outdoor stairs rather than a jet bridge, which felt especially inconvenient after such a long journey. Even though we were traveling First Class, the onboard experience was surprisingly poor. There were no meaningful snack options, no decent coffee available to order, and the aircraft was so small that there was barely enough overhead space for carry-on luggage. The staff experience was also disappointing and lacked the warmth or attentiveness we had experienced on our international flights. To make matters worse, the flight departed late, extending an already very long travel day. Overall, the combination of the outdated terminal, uncomfortable boarding process, limited First Class service, small aircraft, poor staff experience, and delay made this an extremely unpleasant final leg of our journey. It significantly worsened our exhaustion and jet lag rather than making the connection home easier. Unfortunately, this experience was bad enough that I do not plan to travel with American Airlines again in the future.

2.0 MediocreAnonymous, Aug 2026
Read more American Airlines reviews

Our experience with American Airlines was extremely disappointing and honestly made an already exhausting international journey much worse. After flying all the way from Melbourne and dealing with significant jet lag, the American Airlines experience at LAX was the last thing we needed. The terminal and boarding area felt very old and uncomfortable, with little to no air conditioning and only old fans running in the area. Boarding was also through outdoor stairs rather than a jet bridge, which felt especially inconvenient after such a long journey. Even though we were traveling First Class, the onboard experience was surprisingly poor. There were no meaningful snack options, no decent coffee available to order, and the aircraft was so small that there was barely enough overhead space for carry-on luggage. The staff experience was also disappointing and lacked the warmth or attentiveness we had experienced on our international flights. To make matters worse, the flight departed late, extending an already very long travel day. Overall, the combination of the outdated terminal, uncomfortable boarding process, limited First Class service, small aircraft, poor staff experience, and delay made this an extremely unpleasant final leg of our journey. It significantly worsened our exhaustion and jet lag rather than making the connection home easier. Unfortunately, this experience was bad enough that I do not plan to travel with American Airlines again in the future.

Horrible. No AC. No Air inside the plane. We had to deplane twice! It is late almost 5 hrs in total. I almost passed out and about to call 911. I asked the crew to be honest and open the door. The lady next to me was lay down in the floor due to heat and no air inside the plane. I got headaches, can’t wait the replacement flight about midnight Dallas time. I end it up rebook for next day flight and stay overnight using my own pocket in a hotel nearby due to headaches and can’t breath. I still have a headache this morning. Still not decided yes how to file this issue to AA and/or FAA.

Initial flight had an engine overheat - returned to DFW. Had another plane ready, but crew timed out. Had to wait 5h for boarding. Fully boarded and pilot says plane is not flight worthy. Deplane and go to the other end of the terminal. Wait an hour to board third plane because the crew couldn’t leave the second plane because no wheelchairs were brought to remove passengers. Finally take off and there is no catering (in flight service) even in first class. Very much an AA failure.

The flight attendant was very polite and attentive. The food was good.

Was put into a seat right behind the toilet that had no entertainment possible but did have plenty of leg room over noisy part of plane.

Flight: Started on time. Comfortable flight. Arrived on time. Crew: Very cordial and helpful. Drinks and snack was served with a smile. Overall enjoyed the trip. Regards, Hari Doss Chanchala Doss

A first class seat should fit a fat person, and this doesn't. The trays in the armrest are less functional than an ordinary tray in the back of the seat.

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

This was a horrible experience. For a first class experience, my chair was held together by 3M tape - and I have a photo. The crew weren’t very attentive, somewhat dismissive and forgot my drink and snack, the chair reclined about 3 inches on a 6-hour cross country flight. I was also not informed that there was no lounge available in Newark airport because of renovations, so all around this was one of the worst experiences and I would actively avoid both American and Alaska Air going forward.

Long 5 hour and 45 min flight and only one drink service and cookie snack

Everything you need to know for your flight from La Crosse to San Francisco

Information on your arrival and departure airports