STL - ECP

$114 Find Cheap Flights from St. Louis to Panama City - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 8/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$227
Typical prices: $316-$538
Southwest
Tue 8/18Thu 8/20
STL - ECP • Non-stop
Cheapest one-way
$114
Typical prices: $198-$342
Southwest
Sat 8/22
STL - ECP • Non-stop
Top airlines
Cheapest • from $227 (round-trip)
Best reviews • 8.0 score
Airline reviews
Airline reviews
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Airline reviews
Airline reviews
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Nonstop flights
You can fly direct with Southwest. Average duration is 1h 46m
Direct flights
Direct flights
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Direct flights
Direct flights
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Top layover airports
Cheapest • Avg $314 (round-trip)
Shortest trip • 4h 19m (one-way)
Insights
Insights
Insights
Insights
When to book
in advance
Our data shows that travelers who book at least 4 weeks in advance save around 16% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
Cheapest • 18% price drop
Most popular
Good to know
Good to know
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Good to know
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We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Panama City (STL-ECP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Panama City

Tue, Aug 18 - Thu, Aug 20
Southwest Logo
1:55 pm - 3:40 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
5:10 pm - 6:55 pm
ECP
-
STL
1h 45mnonstop
$227Southwest
Tue, Aug 18 - Thu, Aug 20
Southwest Logo
1:55 pm - 3:40 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
4:10 pm - 10:05 pm
ECP
-
STL
5h 55m
1 stop
$237Southwest
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
1:55 pm - 3:40 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
9:10 am - 4:45 pm
ECP
-
STL
7h 35m
2 stops
$242Southwest
Sat, Sep 5 - Sat, Sep 12
Southwest Logo
2:05 pm - 6:10 pm
STL
-
ECP
4h 05m
1 stop
Southwest Logo
9:30 am - 3:30 pm
ECP
-
STL
6h 00m
1 stop
$247Southwest
Tue, Aug 18 - Thu, Aug 20
Southwest Logo
8:35 am - 3:00 pm
STL
-
ECP
6h 25m
2 stops
Southwest Logo
11:20 am - 7:45 pm
ECP
-
STL
8h 25m
1 stop
$252Southwest
Sat, Sep 5 - Sat, Sep 12
Southwest Logo
4:20 pm - 6:05 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
11:45 am - 1:30 pm
ECP
-
STL
1h 45mnonstop
$253Southwest
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
12:50 pm - 6:10 pm
STL
-
ECP
5h 20m
2 stops
Southwest Logo
9:10 am - 4:45 pm
ECP
-
STL
7h 35m
2 stops
$257Southwest
Sat, Sep 5 - Sat, Sep 12
Southwest Logo
12:20 pm - 2:05 pm
STL
-
ECP
1h 45mnonstop
Southwest Logo
9:30 am - 3:30 pm
ECP
-
STL
6h 00m
1 stop
$258Southwest
Mon, Nov 23 - Wed, Dec 2
Delta Logo
1:30 pm - 7:36 pm
STL
-
ECP
6h 06m
1 stop
Delta Logo
11:15 am - 6:01 pm
ECP
-
STL
6h 46m
1 stop
$268Delta
Sat, Sep 5 - Sat, Sep 12
Southwest Logo
2:05 pm - 6:10 pm
STL
-
ECP
4h 05m
1 stop
Southwest Logo
8:15 am - 4:40 pm
ECP
-
STL
8h 25m
2 stops
$278Southwest
Booking Insights

KAYAK's insights & trends for St. Louis to Panama City flights

Get data-powered insights and trends into flights from St. Louis to Panama City to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from St. Louis to Panama City, Florida?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from St. Louis to Panama City, Florida departing in August.

Flight prices are below average for this route right now.

Flights to Panama City, Florida from St. Louis usually cost between $326 and $513 in August.
The lowest price found in the past 5 days was $227 on Southwest (Aug 18-Aug 20).

What is the cheapest month to fly from St. Louis to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Panama City is December, where tickets cost $302 (return) on average. On the other hand, the most expensive months are June and May, where the average cost of round-trip tickets is $443 and $425 respectively.

Can I save money by flying with a layover from St. Louis to Panama City?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 2 stops layover the cheapest option at $303 on average.

How far in advance should I book a flight from St. Louis to Panama City?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from St. Louis to Panama City, you should book around 4 weeks before departure, which saves you about 16% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 7 weeks before departure.

Good to know

Low season

December

Cheapest flight

$114
Best time to beat the crowds with an average 19% drop in price.
Most popular time to fly with an average 9% increase in price.
Flight from St. Louis to Panama City

When to book flights from St. Louis to Panama City

Are your dates flexible? Find out the best times to travel from St. Louis to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Panama City

  • What is the cheapest flight from St. Louis to Panama City?

    In the last 5 days, the lowest price for a flight from St. Louis to Panama City was $114 for a one-way ticket and $227 for a round-trip.

  • Do I need a passport to fly between St. Louis and Panama City?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airlines offer Wi-Fi service onboard planes from St. Louis to Panama City?

    Only JetBlue offers inflight Wi-Fi service on the St. Louis to Panama City flight route.

  • Which aircraft models fly most regularly from St. Louis to Panama City?

    The Boeing 737 MAX 8 is the aircraft model that flies most regularly on the St. Louis to Panama City flight route.

  • Which airline alliances offer flights from St. Louis to Panama City?

    oneworld, and SkyTeam are the airline alliances operating flights between St. Louis and Panama City, with oneworld being the most commonly used for this route.

  • On which days can I fly direct from St. Louis to Panama City?

    There are nonstop flights from St. Louis to Panama City on a daily basis.

  • Which is the best airline for flights from St. Louis to Panama City, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from St. Louis to Panama City are Southwest and Delta. With an average price for the route of $427 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $316 and an overall rating of 7.8.

  • How does KAYAK find such low prices on flights from St. Louis to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and ECP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from St. Louis to Panama City

  • Looking for a cheap flight? 25% of our users found flights on this route for $362 or less round-trip.

Prefer to fly direct from St. Louis to Panama City?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Lambert-St Louis to Panama City NW Florida Beaches.
Find which airlines fly direct from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport, which days they fly and book direct flights.

Direct departures

Lambert-St Louis to Panama City NW Florida Beaches

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Direct returns

Panama City NW Florida Beaches to Lambert-St Louis

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Reviews of the top 3 airlines serving from St. Louis to Panama City

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4238 reviews
7.0Food
7.5Entertainment
8.0Comfort
8.1Boarding
8.6Crew
Airline reviews

Snacks are always pretzels. Why can't you also offer peanuts ?

6.0 GoodAnonymous, Mar 2026
STL - HOU
Read more Southwest reviews

Snacks are always pretzels. Why can't you also offer peanuts ?

Only downside was the legroom and seat width, which is always a problem unless I spend more for a premium seat.

Very good. Sad to learn Southwest is going start to charge for bags

Exceptional crew! Friendly and professional. Pleasant attitude and treated everyone with respect.

The flight was promptly on schedule and Southwest delivered everything they promised. No excuses for any shortfalls just 100% ownership of their responsibilities and business. The boarding and seating policy is a complete shambles. What started out as a great idea when Southwest first hit the market has been turned into a disaster due to the lack of integrity in many of the people who fly Southwest and take advantage of Southwest generosity at the expense of their fellow passengers.

Crew was excellent - Plane was fine. Media was good, could use more kid shows; Not a fan of the brownie brittle -- snack could be slightly better.

Left on time and arrived early. Brand new plane and no parts missing. Comfortable seats. The actual Captain spoke prior to the flight and reassured everyone about safety. Crew was so nice and fun. Perfect flight!

Everything went smoothly and the plane wasn’t full. It was delayed though. The delay was increased due to a crew change which was frustrating.

Love Southwest! Always a good trip with a happy crew who goes out of their way to be kind and fun.

friendly staff for the most part. they thought we were going to have bad turbulence so no drink service. there wasn't any turbulence. Iwish you had a choice of snacks

We were skipped when the snack cart passed and then the attendant said we weren’t . I am disabled and was in a row toward the back of the plane which was very difficult for me to navigate. Disabled people should not be forced to walk the plank.

Flight was delayed and then "they did not have time to load food". No snack or drink at all for 1.5 how flight. Somebody wasn't prepared.

From checking to boarding, it was a seamless experience. The service agents were so helpful. The flight crew was so pleasant.

No service flight that took 5 hrs and a stop at an unscheduled airport. Crew and pilots did their jobs

Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!

My flight was canceled after being rescheduled for four days canceling my trip. Kayak and everyone affiliated with it I.e the airlines, and just fly have been excruciating to deal with. My trip to visit family had to be canceled as there was no way to make it. I am furious at all of you.

They delayed our flight because of bad weather in NY which was completely understandable. Then they cancelled our flight and a later flight that evening. The earliest we could fly was the next morning. We ended up buying last minute tickets on another airline and made it home slightly delayed but safely that evening. Delta kept saying it was weather related but if that was the case how did we make it back on another airline? The weather in NY was cloudy but not bad.

The plane smelled like a sewer. Multiple passengers complained. It’s a safety and quality issue to clean these planes.

We checked one bag. That was fast and the agent was fast and super nice. At the gate, boarding was fast and efficient. Flight was uneventful which was great because it was early in the morning and most folks were sleeping. Landing was great. Delta does a really good job of making the flying experience better all around considering you are sitting in such a small space on a plane for several hours. Flight from ALT to Panama City was short and uneventful as well. No entertainment but no need since it was such a short flight.

We were delayed 2 hours leaving STL. I had 20 mins from when we landed in SLC terminal A to make it to SLC terminal B. I had to actually run! thankfully I made my flight but 3/4 legs were delayed to some capacity.

My luggage was not sent with us. Not sure if this is Envoy Air responsibility but that was a very BAD experience

American delayed the flight for a crew rest period. The delay occurred late in the evening - the earliest i can find is 10:20 pm. With a 6 am flight anyone on the flight would have already have been asleep (unless you are insane, a vampire or on drugs) and at least for me i was already on the way to the airport at 445 am the next morning when i discovered they delayed the flight until 9 am. Given the incoming flight was in the air at 6 pm the evening before this should have been figured out a lot more timely that was there only crew to use. Just frustrating given there is no consideration for customer experience anymore in flying.

Good crew and flight was on time. It’s a small plane with limited overhead luggage space. They said the overhead space was full and I had to check my bag. There was still space when I got on. Waiting for my checked luggage added 30 minutes to my trip. Not the end of the world but also not great.

Trip delayed for 2 hours because of rain. We boarded and have to get down the flight and reboard again.

No enough space plus only allowing one laggage instead of two like other airlines.

Qatar airways ,boarding arrangements at Hamid international airport could been better

Two flight changes before the scheduled flight. On the day of the flight, the flight was delayed, which caused the connecting flight to be missed. Then, I was directed to another airport (CUN) and traveled to Tulum. American gave a $12 voucher for lunch. The least expensive item on the menu at a Mexican restaurant was $9.99. Driving to Tulum was a bad auto crash, and traffic was delayed two-plus hours. The bottom line is that we should have been at the hotel at noon, but it ended up at 11:30 PM.

Miami lounges were overcrowded and we were unable to get in. We only had a short time. But the banks are too tight in all American hubs

Overall boarding and debarking is a joke. I dont even bring luggage anymore on trips because you can never allow them to be place then in the overhead bin or you have to pay or you check them which is even worse having to wait for your luggage on the tarmac.

First time flying internationally with AA and probably my last. Not military friendly at all. Didn't allow free checked bag for military family members (dependents) on orders like other airlines. We were charged $100 for baggage weight overage (5 lbs!)even though we had military orders allowing us extra.. Didn’t allow military members to board early. Inefficient and long wait time to board. Seats are smaller and more uncomfortable than other airlines.. no drink service for over 7 hrs of flight! After initial meal was served, the crew never offered a snack or drinks until the breakfast's was served 1 1/2 hrs before landing. Overall expensive and poor experience for the entire flight.

Everything you need to know for your flight from St. Louis to Panama City

Information on your arrival and departure airports