STL - ECP

$89 Find Cheap Flights from St. Louis to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Panama City, as well as popular online travel agencies
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Flight Deals

Cheap Flights from St. Louis to Panama City (STL-ECP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Panama City

Mon, Oct 13 - Tue, Oct 21
Southwest Logo
8:35 am - 10:20 amSTL-ECP
1h 45mnonstop
Southwest Logo
4:05 pm - 10:05 pmECP-STL
6h 00m1 stop
$207Southwest
Find Deal
Mon, Oct 27 - Sat, Nov 1
Southwest Logo
5:00 am - 1:20 pmSTL-ECP
8h 20m2 stops
Southwest Logo
8:00 am - 2:30 pmECP-STL
6h 30m1 stop
$212Southwest
Find Deal
Mon, Oct 13 - Tue, Oct 21
Southwest Logo
6:45 pm - 10:35 pmSTL-ECP
3h 50m1 stop
Southwest Logo
4:05 pm - 10:05 pmECP-STL
6h 00m1 stop
$217Southwest
Find Deal
Mon, Oct 27 - Sat, Nov 1
Southwest Logo
8:35 am - 10:20 amSTL-ECP
1h 45mnonstop
Southwest Logo
8:00 am - 2:30 pmECP-STL
6h 30m1 stop
$242Southwest
Find Deal
Sun, Oct 19 - Thu, Oct 23
American Airlines Logo
6:00 am - 1:21 pmSTL-ECP
7h 21m1 stop
American Airlines Logo
3:38 pm - 8:51 pmECP-STL
5h 13m1 stop
$252American Airlines
Find Deal
Sun, Oct 19 - Thu, Oct 23
American Airlines Logo
6:00 am - 1:21 pmSTL-ECP
7h 21m1 stop
American Airlines Logo
2:40 pm - 10:55 pmECP-STL
8h 15m2 stops
$257American Airlines
Find Deal
Fri, Oct 3 - Tue, Oct 7
Delta Logo
11:04 am - 3:51 pmSTL-ECP
4h 47m1 stop
Delta Logo
7:10 am - 12:35 pmECP-STL
5h 25m1 stop
$297Delta
Find Deal
Tue, Feb 24 - Thu, Feb 26
Delta Logo
11:51 am - 3:17 pmSTL-ECP
3h 26m1 stop
Delta Logo
7:05 pm - 11:40 pmECP-STL
4h 35m1 stop
$331Delta
Find Deal
Fri, Oct 3 - Fri, Oct 10
United Airlines Logo
6:30 am - 4:16 pmSTL-ECP
9h 46m2 stops
United Airlines Logo
3:03 pm - 10:00 pmECP-STL
6h 57m1 stop
$424United Airlines
Find Deal
Fri, Oct 3 - Tue, Oct 7
United Airlines Logo
8:25 am - 4:16 pmSTL-ECP
7h 51m1 stop
United Airlines Logo
5:08 pm - 10:00 pmECP-STL
4h 52m1 stop
$456United Airlines
Find Deal

Everything you should know

Top airlines
Southwest
Cheapest • from $207 (round-trip)
Southwest
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to book
3 weeks
in advance
Our data shows that travelers who book at least 3 weeks in advance save around 44% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
October
Cheapest • 17% price drop
June
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Cheapest round-trip
$207
Overall average: $339
Southwest
Mon 10/13Tue 10/21
STL - ECP • Non-stop
Cheapest non-stop
$434
Typical prices: $228-280
Southwest
Mon 10/13Tue 10/21
STL - ECP • Non-stop
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Booking Insights

KAYAK's insights & trends for St. Louis to Panama City flights

Get data-powered insights and trends into flights from St. Louis to Panama City to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from St. Louis to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Panama City is October, where tickets cost $339 (return) on average. On the other hand, the most expensive months are November and March, where the average cost of round-trip tickets is $486 and $465 respectively.

Can I save money by flying with a layover from St. Louis to Panama City?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 2 stops layover the cheapest option at $303 on average.

How far in advance should I book a flight from St. Louis to Panama City?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from St. Louis to Panama City, you should book around 3 weeks before departure, which saves you about 44% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 11 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$89
Best time to beat the crowds with an average 1% drop in price.
Most popular time to fly and prices are also 0% lower on average.
Flight from St. Louis to Panama City

When to book flights from St. Louis to Panama City

Are your dates flexible? Find out the best times to travel from St. Louis to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Panama City

  • What is the cheapest flight from St. Louis to Panama City?

    In the last 3 days, the lowest price for a flight from St. Louis to Panama City was $89 for a one-way ticket and $207 for a round-trip.

  • Do I need a passport to fly between St. Louis and Panama City?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which aircraft models fly most regularly from St. Louis to Panama City?

    The Boeing 737-700 Passenger/BBJ1 (winglets) is the aircraft model that flies most regularly on the St. Louis to Panama City flight route.

  • On which days can I fly direct from St. Louis to Panama City?

    There are nonstop flights from St. Louis to Panama City on a daily basis.

  • Which is the best airline for flights from St. Louis to Panama City, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from St. Louis to Panama City are Southwest and Delta. With an average price for the route of $430 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $392 and an overall rating of 7.9.

  • How does KAYAK find such low prices on flights from St. Louis to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and ECP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from St. Louis to Panama City

  • Looking for a cheap flight? 25% of our users found flights on this route for $192 or less round-trip.

Prefer to fly direct from St. Louis to Panama City?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Lambert-St Louis to Panama City NW Florida Beaches.
Find which airlines fly direct from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport, which days they fly and book direct flights.

Direct departures

Lambert-St Louis to Panama City NW Florida Beaches

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Direct returns

Panama City NW Florida Beaches to Lambert-St Louis

Monday

Southwest

Southwest

Tuesday

Southwest

Southwest

Wednesday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Reviews of the top 4 airlines serving from St. Louis to Panama City

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4242 reviews
8.1Boarding
7.0Food
8.0Comfort
7.5Entertainment
8.6Crew
Airline reviews

I wish they had movie screens in the headrests. The seats are much improved, more legroom and recently renovated. Bathroom was clean. Staff was outstanding!!

10.0 ExcellentG, Sep 2025LAS - ATL
Read more Southwest reviews

I wish they had movie screens in the headrests. The seats are much improved, more legroom and recently renovated. Bathroom was clean. Staff was outstanding!!

As always, the entire Southwest experience was wonderful, from online booking to flight to baggage retrieval. Very grateful.

The weather could have been better. There was a 40 minute ATC delay in SFO because of marine fog and a micro cell storm delayed landing and take-off at Nashville. The gate was changed 5 minutes from boarding from gate B3 to gate C23 at Nashville airport.

The quality of Southwest Airlines continues to degrade each time I fly with them. If it were not for the free luggage, I would probably choose another airline. Their prices are a little bit competitive, but way too high for the quality of the service. Southwest is not unique in this way. Domestic flight in the United States of America has continued to be a lower and lower quality product. Very sad when you compare the quality of domestic airlines to that of many international airlines around the world.

I'm not a fan of Southwest's model. I don't like the herding style of boarding.

It is southwest seat was ok. Not the most comfortable seat

Plz don't take away free bags and free seating

Very good. Sad to learn Southwest is going start to charge for bags

Excellent! Only question is how we check in at exactly 24 hours in advance and end up at the end of the B boarding group

Multiple delays and gate changes. Arrived at final destination 6 hours late. All rental cars had been taken.

The staff and the boarding procedure were all amazing . The one flight was not equipped with WIFI which now adays seems odd. All in all the experience was good

Perfect flight both ways. On time, courteous staff, plane comfortable and cool. Best domestic flights I’ve had in awhile.

Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!

Always good but we must do something about people in rows ahead of you that don't put their seats back up when they are suppose to. And It's rough to not be able to even lean over to get something out of my purse.

this crew didn't care much. bumping carts into seats more times than i care to remember

Everything was fine except the entertainment was not working for half of the flight.

Easy boarding with an extremely kind attendant. Seats were spacious and we had 3 seats for 2 people so we could stretch out. Comfortable air flow and very attentive and hospital attendants. Bathrooms and food were the only negative. Bathrooms were so small you could hardly get in and close the door. I don’t think an obese person would fit or a person with a movement disability. Food was the trending food for flights, nonexistent. We spent $40 getting sandwich and snack at airport for our 6 hour flught.

My flight was canceled after being rescheduled for four days canceling my trip. Kayak and everyone affiliated with it I.e the airlines, and just fly have been excruciating to deal with. My trip to visit family had to be canceled as there was no way to make it. I am furious at all of you.

They delayed our flight because of bad weather in NY which was completely understandable. Then they cancelled our flight and a later flight that evening. The earliest we could fly was the next morning. We ended up buying last minute tickets on another airline and made it home slightly delayed but safely that evening. Delta kept saying it was weather related but if that was the case how did we make it back on another airline? The weather in NY was cloudy but not bad.

I am very bothered by the events today. I can't believe the flight attendants allowed someone to take my seat and made me move. It was embarrassing. I was in the right. The lady just didn't want move. I can't believe delta would allow this to stand and disrespect my rights as a passenger. The lady complained about her leg and that she couldn't move. Firstly somehow she was able to make it to row 24. Not sure how much her leg could have hurt. Secondly, I'm in plenty of pain myself. I just finished chemotherapy a several weeks ago. My body is constantly sore. Yet deltas flight attendants didn't appropriately protect my rights. In the end they found me a seat on the plane but I want to understand how delta can operate this way. They in essence allowed a bully to get their way.

Flight was delayed not sure why no explanation given and no apologies either. Otherwise the flight was fine

While waiting to claim my checked luggage, I discovered the airline had lost it. After a long wait and inquiries, I discovered it was on another flight. Fortunately, the airline finally sent my luggage home.

Flight delays numerous times. Everytime we would get close to boarding it would be delayed again. Strung along the entire time.

This flight never occurred because AA couldn’t get their act together.

During service there was a garbage/beverage spill near our seats that never was cleaned up. On a relatively short flight when we’re fortunate enough to actually have in flight movies available, the flight attendants pitching the AADVANTAGE credit card shouldn’t talk for the last 10 minutes of the flight so that we miss the end of the movie.

Waited on the runway for takeoff for 2.5 hours. Air traffic rerouted us. The plane didn't have enough fuel, so had to go back to the gate. Had to wait for a new pilot. Should have landed at 5:22. Didn't land until 9:10. Trash flight.

The boarding was pretty easy. However, the first class seats are not lay flat as other airlines (like JetBlue) has and therefore sleeping was a challenge.

Everything about the flight was lovely…We left early, arrived early, cabin crew were efficient and helpful. Flight was easy and most pleasant.

Would have thought that they would gas up plane before everyone got on board

Fine. On time, cabin service was fine, bag arrived. All good. Flying into DCA so did not collide with any helicopters, which is also good. Horrid incident that could have and should have been prevented.

Crew was great. No entertainment and food and beverage was for purchase only, even water

It was canceled. The flight wasn’t rescheduled, everyone had to figure out their own new arrangements. They said we would get refunded our original fare and receive an additional $150. We received links for $100 only and they expired before we could activate them.

The plane had originated in Las Vegas at 6:30 in the morning and flew to Moline where we boarded. The flight left around 12:30 PM and there were no boxed snacks available and many of the alcoholic beverages were unavailable. I would find it hard to believe that that many of the passengers coming from Las Vegas at 6:30 in the morning, drank and ate that much of the items. I can only come to the conclusion that someone failed to stock the plane for the round-trip. This is a huge revenue failure for the airline and disappointment for the passengers. The flight crew did not seem happy to be there and did not engage with passengers. Allegiant you can do better.

They did not let my husband on the plane with our service animal at the last minute. Do NOT fly this airline with a service animal!

Tight! Seats are not designed for those of us who wear extra-large clothes.

The non-stop flight from Grand Rapids was excellent. I neither expected or needed a budget flight and Allegiant made the trip easy and for an affordable price, Arriving at the Mesa Airport (AZA) is a delight compared to the international airport. For our return flight, we were able to arrive 75 minutes before the flight, return the rental car, check our bag and make it to the gate in plenty of time. That would never happen at most airports.

Easiest flights I’ve ever taken. Plane was comfortable without overly crowded seating.

Terrible. Still have not received the refund from them. They sent it to some account that I don't even know. Spoke with costumer service and they are unable to help.

I didn’t like it at all. I miss my second flight because of the delay on Allegiant Air now I m stuck in MCO.

Good, but a bit late on take off after loading. Don't like charging for carry ons!

Everything you need to know for your flight from St. Louis to Panama City

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