STL - ECP

$104 Find Cheap Flights from St. Louis to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$201
Overall average: $456
American Airlines
Tue 12/16Tue 12/16
STL - ECP • 1 stop
Cheapest non-stop
$397
Southwest
Wed 4/29Sun 5/3
STL - ECP • Non-stop
Top airlines
American Airlines
Cheapest • from $201 (round-trip)
Southwest
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to book
3 weeks
in advance
Our data shows that travelers who book at least 3 weeks in advance save around 46% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
October
Cheapest • 30% price drop
June
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Nonstop flights
1 day a week
There are direct flights from St. Louis to Panama City 1 day a week: Sat.
Direct flights
Direct flights
Direct flights
Direct flights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Panama City (STL-ECP)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Panama City

Tue, Dec 16 - Tue, Dec 16
American Airlines Logo
6:52 am - 11:38 amSTL-ECP
4h 46m1 stop
American Airlines Logo
1:23 pm - 9:47 pmECP-STL
8h 24m1 stop
$201American Airlines
Find Deal
Tue, Dec 16 - Tue, Dec 16
American Airlines Logo
6:00 am - 4:47 pmSTL-ECP
10h 47m2 stops
American Airlines Logo
5:50 pm - 11:06 pmECP-STL
5h 16m1 stop
$206American Airlines
Find Deal
Mon, Dec 8 - Fri, Dec 12
Delta Logo
5:12 pm - 11:06 pmSTL-ECP
5h 54m1 stop
Delta Logo
6:00 am - 1:02 pmECP-STL
7h 02m1 stop
$217Delta
Find Deal
Mon, Dec 8 - Fri, Dec 12
American Airlines Logo
2:11 pm - 11:10 pmSTL-ECP
8h 59m2 stops
American Airlines Logo
1:23 pm - 9:47 pmECP-STL
8h 24m1 stop
$222American Airlines
Find Deal
Mon, Dec 8 - Fri, Dec 12
American Airlines Logo
2:11 pm - 11:10 pmSTL-ECP
8h 59m2 stops
American Airlines Logo
12:08 pm - 9:47 pmECP-STL
9h 39m2 stops
$227American Airlines
Find Deal
Tue, Mar 3 - Wed, Mar 4
Delta Logo
6:00 am - 11:20 amSTL-ECP
5h 20m1 stop
Delta Logo
5:14 pm - 11:38 pmECP-STL
6h 24m1 stop
$289Delta
Find Deal
Thu, Apr 2 - Mon, Apr 6
Southwest Logo
8:25 am - 9:10 pmSTL-ECP
12h 45m2 stops
Southwest Logo
9:50 am - 3:05 pmECP-STL
5h 15m1 stop
$300Southwest
Find Deal
Sat, Jan 3 - Sat, Jan 17
American Airlines Logo
5:00 am - 10:41 amSTL-ECP
5h 41m1 stop
American Airlines Logo
12:03 pm - 10:44 pmECP-STL
10h 41m2 stops
$319American Airlines
Find Deal
Tue, Dec 16 - Tue, Dec 16
Southwest Logo
5:45 am - 2:40 pmSTL-ECP
8h 55m2 stops
Southwest Logo
4:25 pm - 10:20 pmECP-STL
5h 55m2 stops
$327Southwest
Find Deal
Thu, Apr 2 - Mon, Apr 6
Southwest Logo
8:25 am - 9:10 pmSTL-ECP
12h 45m2 stops
Southwest Logo
4:55 pm - 12:40 amECP-STL
7h 45m2 stops
$330Southwest
Find Deal
Booking Insights

KAYAK's insights & trends for St. Louis to Panama City flights

Get data-powered insights and trends into flights from St. Louis to Panama City to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from St. Louis to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Panama City is October, where tickets cost $279 (return) on average. On the other hand, the most expensive months are March and December, where the average cost of round-trip tickets is $482 and $456 respectively.

Can I save money by flying with a layover from St. Louis to Panama City?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 2 stops layover the cheapest option at $303 on average.

How far in advance should I book a flight from St. Louis to Panama City?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from St. Louis to Panama City, you should book around 3 weeks before departure, which saves you about 46% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 4 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$104
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 2% increase in price.
Flight from St. Louis to Panama City

When to book flights from St. Louis to Panama City

Are your dates flexible? Find out the best times to travel from St. Louis to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Panama City

  • What is the cheapest flight from St. Louis to Panama City?

    In the last 3 days, the lowest price for a flight from St. Louis to Panama City was $104 for a one-way ticket and $201 for a round-trip.

  • Do I need a passport to fly between St. Louis and Panama City?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which aircraft models fly most regularly from St. Louis to Panama City?

    The Boeing 737-700 Passenger/BBJ1 (winglets) is the aircraft model that flies most regularly on the St. Louis to Panama City flight route.

  • Which airline alliances offer flights from St. Louis to Panama City?

    oneworld, and SkyTeam are the airline alliances operating flights between St. Louis and Panama City, with oneworld being the most commonly used for this route.

  • On which days can I fly direct from St. Louis to Panama City?

    You can catch a nonstop flight from St. Louis to Panama City on on Saturday.

  • Which is the best airline for flights from St. Louis to Panama City, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from St. Louis to Panama City are Southwest and Delta. With an average price for the route of $430 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $353 and an overall rating of 7.9.

  • How does KAYAK find such low prices on flights from St. Louis to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and ECP can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Prefer to fly direct from St. Louis to Panama City?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Lambert-St Louis to Panama City NW Florida Beaches.
Find which airlines fly direct from Lambert-St Louis Airport to Panama City NW Florida Beaches Airport, which days they fly and book direct flights.

Direct departures

Lambert-St Louis to Panama City NW Florida Beaches

Saturday

Southwest

Southwest

See more direct flights

Direct returns

Panama City NW Florida Beaches to Lambert-St Louis

Saturday

Southwest

Southwest

See more direct flights

Reviews of the top 3 airlines serving from St. Louis to Panama City

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4235 reviews
8.1Boarding
8.0Comfort
7.0Food
7.5Entertainment
8.6Crew
Airline reviews

Crew could have been friendlier, maybe I'm spoiled by SW crews. In flight wifi was good. Would be nice to have more food offerings on a 4 plus hour flight

10.0 ExcellentMichael, Nov 2025LAX - BWI
Read more Southwest reviews

Crew could have been friendlier, maybe I'm spoiled by SW crews. In flight wifi was good. Would be nice to have more food offerings on a 4 plus hour flight

Had to get off plane from prior flight even though I had to reboard same plane to continue to my final destination.

Everything a cheap airline should be at normal airline rates.

Delays delays delays. Late taking off, late landing, wait for a gate, etc.

The quality of Southwest Airlines continues to degrade each time I fly with them. If it were not for the free luggage, I would probably choose another airline. Their prices are a little bit competitive, but way too high for the quality of the service. Southwest is not unique in this way. Domestic flight in the United States of America has continued to be a lower and lower quality product. Very sad when you compare the quality of domestic airlines to that of many international airlines around the world.

I'm not a fan of Southwest's model. I don't like the herding style of boarding.

It is southwest seat was ok. Not the most comfortable seat

Plz don't take away free bags and free seating

Very good. Sad to learn Southwest is going start to charge for bags

Excellent! Only question is how we check in at exactly 24 hours in advance and end up at the end of the B boarding group

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

The flight was an hour and a half late departing which was inconvenient

The flight was great. The gate location was way to far away!!!

The flight attendant in first class was beyond rude and didn't care at all about her job. AND the gate agent was even worse than the flight attendant for rudeness. She was awful.

Movie selection was meh. Food was great. Crew as always great. I paid for premium because that’s the only way not to feel like a sardine. That’s how economy should be imo. Sadly passengers have to pay an extra $1000 to get what they should at base price but that’s all airlines. The airline industry in general treats passengers as cargo.

Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!

Always good but we must do something about people in rows ahead of you that don't put their seats back up when they are suppose to. And It's rough to not be able to even lean over to get something out of my purse.

this crew didn't care much. bumping carts into seats more times than i care to remember

Everything was fine except the entertainment was not working for half of the flight.

Delays to take off and to leave the plane after landing added a lot of time to this flight.

It was a red eye flight, so no meals were provided, but it was fine with snacks. The seats felt cramped and almost too narrow.

We didn't take off until an hour after we boarded.

Wish they had the seat-back video screens for watching movies or playing games.

Very good but wish they had the seat-back video screens for movies & games

Flight was delayed not sure why no explanation given and no apologies either. Otherwise the flight was fine

While waiting to claim my checked luggage, I discovered the airline had lost it. After a long wait and inquiries, I discovered it was on another flight. Fortunately, the airline finally sent my luggage home.

Flight delays numerous times. Everytime we would get close to boarding it would be delayed again. Strung along the entire time.

This flight never occurred because AA couldn’t get their act together.

During service there was a garbage/beverage spill near our seats that never was cleaned up. On a relatively short flight when we’re fortunate enough to actually have in flight movies available, the flight attendants pitching the AADVANTAGE credit card shouldn’t talk for the last 10 minutes of the flight so that we miss the end of the movie.

Everything you need to know for your flight from St. Louis to Panama City

Information on your arrival and departure airports