$109 Find Cheap Flights from St. Louis to Panama City - Compare and Save

Among airlines operating St. Louis to Panama City flights:

• Southwest: offers free seat selection

Extra legroom and free seat selection availability depends on fare class and route.

Only Southwest operates flights between St. Louis and Panama City.

Flights from St. Louis to Panama City usually depart from Lambert-St Louis (STL) and arrive at Panama City NW Florida Beaches (ECP).

Here are some options for this route, based on selected ticket types and cabin classes:

• Southwest: a cabin bag in Economy Class class

Bag allowance can vary by ticket type, cabin class, route and airline, so travelers should check the fare details before booking.

Only Economy Class is available on flights from St. Louis to Panama City.

On this route, layover flights are cheaper than nonstop options on average. Layover fares average $314 round-trip via Washington, D.C. Reagan-National (DCA), compared to $446 for nonstop.

There is no standard. Checked-bag policies vary by airline on this route. Most carriers charge $45–$90 for the first checked bag in economy. Premium fares and elite-status bookings typically include a free checked bag.

The Boeing 737 MAX 8 family is used most often on this route, operated mainly by Southwest. Other aircraft seen on the route include Boeing 737 variants.

One-stop flights from St. Louis to Panama City most commonly connect through:

• Atlanta Hartsfield-Jackson (ATL) - 74% of one-stop connections
• Charlotte Douglas (CLT) - 9% of one-stop connections
• Nashville Intl (BNA) - 6% of one-stop connections
• Chicago O'Hare Intl (ORD) - 4% of one-stop connections

Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

Yes. Being flexible with your travel dates can save you up to 25% on the St. Louis to Panama City route. Monday is the cheapest departure day at $336 round-trip on average, while Friday is the most expensive at $445, a difference of $109. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

These are the earliest and latest flight times available from St. Louis to Panama City:

• Earliest: departs at 8:00 am and lands at 9:46 am
• Latest: departs at 7:15 pm and lands at 9:01 pm.

The flight takes about 1h 46m.

Last-minute fares on this route - booked within 2 weeks of departure - run 25% above the route average of $381. Book 7 weeks before departure for the lowest fares.

A nonstop flight from St. Louis to Panama City takes 1h 46m, covering 635 miles.

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $227 to $1,179. That means the highest observed fare was about 5x higher than the lowest one.

One-way fares from St. Louis to Panama City are currently lower than usual. Average one-way flight prices are about $123, which is 42% below the typical average for this route.

Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 18m, compared with 4h 25m via Nashville Intl (BNA) and 5h 07m via Dallas/Fort Worth (DFW).

Panama City NW Florida Beaches Airport (ECP) hosts 5 major car rental companies, with daily rates starting from around $29 for economy cars. Top options include:
• Dollar
• Budget
• Hertz
• Alamo
• Avis

Round-trip flights from St. Louis to Panama City range from $312 to $466, with an average of $381 over the past 12 months. Anything below $312 counts as a good deal.