STL - PTY

$252 Find Cheap Flights from St. Louis to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Panama City, as well as popular online travel agencies
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Flight Deals

Cheap Flights from St. Louis to Panama City (STL-PTY)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Panama City

Mon, Oct 13 - Thu, Oct 23
Delta Logo
6:00 am - 12:56 pmSTL-PTY
6h 56m1 stop
Delta Logo
2:21 pm - 11:41 pmPTY-STL
9h 20m1 stop
$386Delta
Find Deal
Tue, Oct 14 - Thu, Oct 23
United Airlines Logo
6:15 am - 6:37 pmSTL-PTY
12h 22m1 stop
United Airlines Logo
10:00 am - 10:00 pmPTY-STL
12h 00m1 stop
$393United Airlines
Find Deal
Mon, Oct 13 - Tue, Oct 21
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
3:30 pm - 10:49 amPTY-STL
19h 19m2 stops
$398United Airlines
Find Deal
Tue, Oct 14 - Thu, Oct 23
American Airlines Logo
3:03 pm - 2:03 pmSTL-PTY
23h 00m2 stops
American Airlines Logo
3:15 pm - 9:35 amPTY-STL
18h 20m2 stops
$399American Airlines
Find Deal
Thu, Oct 23 - Mon, Oct 27
United Airlines Logo
6:15 am - 6:37 pmSTL-PTY
12h 22m1 stop
United Airlines Logo
3:41 pm - 6:47 pmPTY-STL
27h 06m1 stop
$401United Airlines
Find Deal
Mon, Oct 13 - Fri, Oct 24
Delta Logo
6:00 am - 12:56 pmSTL-PTY
6h 56m1 stop
Delta Logo
2:21 pm - 12:35 pmPTY-STL
22h 14m1 stop
$403Delta
Find Deal
Thu, Oct 23 - Mon, Oct 27
United Airlines Logo
5:00 am - 6:37 pmSTL-PTY
13h 37m2 stops
United Airlines Logo
3:41 pm - 6:47 pmPTY-STL
27h 06m1 stop
$406United Airlines
Find Deal
Sun, Oct 12 - Thu, Oct 23
United Airlines Logo
6:15 am - 6:37 pmSTL-PTY
12h 22m1 stop
United Airlines Logo
10:00 am - 10:00 pmPTY-STL
12h 00m1 stop
$410United Airlines
Find Deal
Sun, Oct 12 - Tue, Oct 21
United Airlines Logo
6:15 am - 2:14 pmSTL-PTY
7h 59m1 stop
United Airlines Logo
3:30 pm - 10:49 amPTY-STL
19h 19m2 stops
$415United Airlines
Find Deal
Thu, Oct 23 - Mon, Oct 27
American Airlines Logo
6:08 pm - 2:03 pmSTL-PTY
19h 55m1 stop
American Airlines Logo
3:15 pm - 9:28 amPTY-STL
18h 13m2 stops
$473American Airlines
Find Deal

Everything you should know

Top airlines
Delta
Cheapest • from $386 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to book
5 weeks
in advance
Our data shows that travelers who book at least 5 weeks in advance save around 13% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
April
Cheapest • 20% price drop
January
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Cheapest round-trip
$386
Typical prices: $412-567
Delta
Mon 10/13Thu 10/23
STL - PTY • 1 stop
Cheapest one-way
$252
Delta
Tue 9/30
STL - PTY • 1 stop
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Booking Insights

KAYAK's insights & trends for St. Louis to Panama City flights

Get data-powered insights and trends into flights from St. Louis to Panama City to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from St. Louis to Panama City?

What’s the cheapest day of the week to fly from St. Louis to Panama City?

The average price of all round-trip flights from St. Louis to Panama City clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from St. Louis to Panama City, look for departures on Tuesdays and avoid leaving on a Sunday, as it's usually the priciest day. When flying back from Panama City, Thursday is the cheapest day to fly and Wednesday is the most expensive.

What is the cheapest month to fly from St. Louis to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Panama City is April, where tickets cost $441 (return) on average. On the other hand, the most expensive months are February and March, where the average cost of round-trip tickets is $641 and $610 respectively.

How far in advance should I book a flight from St. Louis to Panama City?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from St. Louis to Panama City, you should book around 5 weeks before departure, which saves you about 13% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 17 weeks before departure.

Good to know

Low seasonSeptember
Cheapest flight$252
Best time to beat the crowds with an average 0% drop in price.
Most popular time to fly with an average 4% increase in price.
Flight from St. Louis to Panama City

When to book flights from St. Louis to Panama City

Are your dates flexible? Find out the best times to travel from St. Louis to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Panama City

  • What is the cheapest flight from St. Louis to Panama City?

    In the last 3 days, the lowest price for a flight from St. Louis to Panama City was $252 for a one-way ticket and $386 for a round-trip.

  • Do I need a passport to fly between St. Louis and Panama City?

    Yes, you'll most likely have to show a valid passport before boarding the plane in St. Louis and on arrival in Panama City.

  • Which airports will I be using when flying from St. Louis to Panama City?

    St. Louis and Panama City are both served by 1 main airport. You will leave St. Louis from Lambert-St Louis and will be arriving at Panama City Tocumen Intl.

  • Which aircraft models fly most regularly from St. Louis to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from St. Louis to Panama City?

    SkyTeam, Star Alliance, and oneworld are the airline alliances operating flights between St. Louis and Panama City, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from St. Louis to Panama City, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from St. Louis to Panama City are Delta and United Airlines. With an average price for the route of $569 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $558 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from St. Louis to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and PTY can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from St. Louis to Panama City

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7954 reviews
8.5Crew
7.9Comfort
7.9Entertainment
8.2Boarding
7.3Food
Airline reviews

Perfect flight both ways. On time, courteous staff, plane comfortable and cool. Best domestic flights I’ve had in awhile.

10.0 ExcellentAnonymous, Sep 2025CLT - BOS
Read more Delta reviews

Perfect flight both ways. On time, courteous staff, plane comfortable and cool. Best domestic flights I’ve had in awhile.

The food was terrible especially for a 15 hour international flight. The crew was unpleasant as well.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

Quick check in. Everything went smooth. I don't know what can be done about airline food.

Crew was good. The reservation got mixed up and they didn't have my TSA number. I am also a Silver Medallion and wasn't able to use Sky Priority.

Delta made it easy, comfortable and timely. The crew was fantastic.

This route with Delta always has delays or is cancelled. Aircrafts seem smaller and older. I fly Delta quite a bit - haven’t had issues with the international flights. But this route has always been the troublesome one

Nothing special. The crew never went out of their way for anything.

Three seats in first class were broken and while they were able to still acommodate us it was looking very touch and go and they had others they could not acommodate

We had to deboard 2 times due to maintenance issues. They changed the plane, and then we got deviated to LAX due to maibtenance issues on the other plane, had to sleep at LAX and los a full day.

Everything was good, except the seats in economy were so close together, you could barely get out when the seat in front of your was reclined. If the airlines keep jamming in more and more seats, it will become intolerable. I will look for another airline that considers customer comfort and does not keep adding more rows of seats for more profit.

The newer screen was super cool and had the option to watch many different shows or movies. Crew was polite and helpful. However again, many children screaming bloody murder and kicking my seat, and parents doing nothing about it as usual.

Flight was good and crew was super polite. However, there were around 5 kids screaming the WHOLE 2 hours. I understand kids have to come but parents need to do something to control their children. They make the experience terrible, especially after finishing 16 hour shifts at the hospital I needed some sleep, which I did not get.

IAD with the archaic people movers is just a place to be avoided.

Great service on board. Boarding a bit slow due to process. Food was pretty average.

Tastless food and too obvious lack of enthusiasm for service in the economy vesus business class

All of the United employees I interacted with were professional and courteous. The aircraft was clean, the food on the flight was good. No complaints here.

I had no checked baggage but was required to hand over carry on baggage at the door of the plane. There was a lot of overboard space in the plane and I was one of the last ones. I ran to get my carry on but it was gone. I was given back at the plane door in Toronto, so the wait was not as long as it would have been at the carousel.

Armrest controller on my seat 35D and nextbooennseat 35E did not work right. Hard to press buttons to recognize and 35D had constantnpressure either upmost down somit was nearly impossible to make selections. .

Given it’s a red-eye into Charolotte, we didn’t get any food. The survey does not include “N/A” so the rating will be skewed.

Great. Quick and quiet and east. The breakfast choices were a welcome surprise!

American airlines suck they delay the flights all the time made me sleep in an airport because my flight was delayed and I miss my connecting flight

There's nothing I liked about it. For first off I scheduled this trip two weeks in advance then they delayed my flight which messed up my whole trip. So I scheduled it for the following weekend thinking there won't be a delay and guess what as soon as I got to the airport we said in the airplane on the tarmac for an hour and a half. Not only was it delayed I missed my connecting flight meaning I had to stay the night at Dallas-Fort Worth airport sleeping on the floor. I will tell you this I will never fly American airlines ever again I have had nothing but horrible experience with them and I just throw money at them

The stewardess hit me with the food kart twice on the head and didn't say I'm sorry once. The same stewardess gave me a warm Apple Juice with No ice. The Flight was delayed for Departure 6 times, starting from 2:36pm, finally taking off 7:50pm. I was late picking up my child from the sitter by 3 hours.

Don’t know they cancelled the flight day before I was to leave. They sent a email at 9:00 pm at night saying they cancelled. That is the smooth way to say we don’t want your business! I think they didn’t have enough people booking so they cancelled the flight! It’s all about the money anymore there is no honesty in business.

Having to reschedule flights a day later, they loaded by luggage on the wrong plane from Little rock now I have to HOPE they deliver it to where im staying like they said would. International flight crew was very disgruntled and not very friendly.

We will be writing a long, detailed letter to corporate about our awful experience with American airlines.

It took way too long to diagnose and solve the problem of a broken crew member cabin seat. Though compensation for the volunteer who left the flight was very kind.

The entertainment package was vast and the selections were very current. Keep updating it was great.

Everything you need to know for your flight from St. Louis to Panama City

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