STL - PTY

$266 Find Cheap Flights from St. Louis to Panama City - Compare and Save

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Everything you should know

Cheapest round-trip
$592
Typical prices: $566-$826
American Airlines
Thu 1/25Mon 1/29
STL - PTY • 2 stops
Cheapest one-way
$266
Typical prices: $236-$347
American Airlines
Thu 1/11
STL - PTY • 2 stops
Nonstop flights
Not available
There are currently no direct flights between St. Louis and Panama City. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
April
Cheapest • 26% price drop
April
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Houston George Bush Intcntl (IAH)
Cheapest • Avg $681 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 8h 01m (one-way)
Insights
Insights
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We hope you love your trip to Panama City!
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Booking Insights
Flight Deals

Cheap Flights from St. Louis to Panama City (STL-PTY)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Panama City

Mon, Jan 25 - Fri, Jan 29
American Airlines Logo
6:00 pm - 1:26 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
18h 26m2 stops Dallas/Fort Worth Miami
American Airlines Logo
4:55 pm - 2:15 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
22h 20m2 stops Miami Dallas/Fort Worth
$592American Airlines
Mon, Jan 11 - Wed, Jan 20
American Airlines Logo
5:49 pm - 1:26 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
18h 37m2 stops Chicago O'Hare Intl Miami
American Airlines Logo
2:26 pm - 10:42 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 16m1 stop Miami
$592American Airlines
Mon, Jan 11 - Wed, Jan 20
United Airlines Logo
6:15 am - 5:12 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
9h 57m1 stop Houston George Bush Intcntl
United Airlines Logo
4:41 pm - 9:31 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
17h 50m1 stop Houston George Bush Intcntl
$667United Airlines
Thu, Feb 25 - Mon, May 17
United Airlines Logo
6:10 am - 5:12 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
10h 02m1 stop Houston George Bush Intcntl
United Airlines Logo
3:30 pm - 9:42 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
18h 12m1 stop Houston George Bush Intcntl
$667United Airlines
Tue, Feb 23 - Tue, May 18
Delta Logo
6:00 am - 1:55 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 55m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:25 pm - 8:12 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
17h 47m1 stop Atlanta Hartsfield-Jackson
$667Delta
Sat, Jan 16 - Sat, Feb 13
Delta Logo
6:00 am - 2:04 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
7h 04m1 stop Atlanta Hartsfield-Jackson
Delta Logo
1:40 pm - 11:39 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
10h 59m1 stop Atlanta Hartsfield-Jackson
$706Delta
Sun, Feb 21 - Fri, May 14
Copa Airlines Logo
10:05 am - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
8h 33m1 stop Houston George Bush Intcntl
Copa Airlines Logo
7:55 am - 4:44 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
8h 49m1 stop Houston George Bush Intcntl
$785Copa Airlines
Sun, Feb 21 - Fri, May 21
Copa Airlines Logo
10:05 am - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
8h 33m1 stop Houston George Bush Intcntl
Copa Airlines Logo
9:45 am - 7:40 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 55m1 stop Newark
$785Copa Airlines
Fri, Nov 27 - Fri, Dec 4
Multiple Airlines Logo
1:20 pm - 9:10 amSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
18h 50m2 stops Orlando Bogotá El Dorado
Multiple Airlines Logo
5:30 am - 10:57 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
30h 27m3 stops San Salvador El Salvador Intl Orlando Denver Intl
$871Multiple Airlines
Fri, Jan 1 - Sun, Jan 10
Multiple Airlines Logo
6:21 pm - 8:31 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
25h 10m1 stop Atlanta Hartsfield-Jackson
Multiple Airlines Logo
12:03 pm - 10:30 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
23h 27m2 stops Fort Lauderdale Denver Intl
$1,048Multiple Airlines
Booking Insights

Price, demand and travel trends for St. Louis to Panama City flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from St. Louis to Panama City?

Round-trip flights from St. Louis to Panama City typically range from $566 to $826. The lowest price found in the past 5 days was $592, on American Airlines.

What's the cheapest day of the week to fly from St. Louis to Panama City?

Based on deals KAYAK users found in the last 12 months, Wednesday is the cheapest day of the week to fly from St. Louis to Panama City. It’s 24% cheaper than the average day, while Sunday is the most expensive, with prices 53% higher.

What’s the cheapest month to fly from St. Louis to Panama City?

•April is the cheapest month to fly from St. Louis to Panama City at $528 round-trip.
•July ($1,019) and September ($810) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 92% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for St. Louis to Panama City flights

Low season

October

Cheapest flight

$266
Beat the crowds with an average 69% drop in travelers.
The most popular month to fly with an average 50% increase in travelers.
One-way flight from St. Louis to Panama City

When to book flights from St. Louis to Panama City

Are your dates flexible? Find out the best times to travel from St. Louis to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your St. Louis to Panama City flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from St. Louis to Panama City?

    Three cabin classes are available on flights from St. Louis to Panama City:

    • Economy Class
    • Business Class
    • First Class

  • How long is a flight from St. Louis to Panama City?

    A nonstop flight from St. Louis to Panama City takes 00m, covering 2,159 miles.

  • Do I need a passport to fly from St. Louis to Panama City?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a St. Louis to Panama City flight?

    Round-trip flights from St. Louis to Panama City range from $566 to $826, with an average of $718 over the past 12 months. Anything below $566 counts as a good deal.

  • Have flight prices from St. Louis to Panama City changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $592 to $3,039. That means the highest observed fare was about 5x higher than the lowest one.

  • How are flight prices from St. Louis to Panama City looking right now?

    One-way fares from St. Louis to Panama City are currently higher than usual. Average one-way flight prices are about $387, which is 38% above the typical average for this route.

  • What car rental options are available at Panama City Tocumen Intl Airport (PTY)?

    Panama City Tocumen Intl Airport (PTY) hosts 5 major car rental companies, with daily rates averaging $16 for economy cars. Top options include:

    • Avis
    • Ace
    • Europcar
    • Budget
    • Thrifty

  • Which airports can I use when flying from St. Louis to Panama City?

    Flights from St. Louis to Panama City usually depart from Lambert-St Louis (STL) and arrive at Panama City Tocumen Intl (PTY).

  • Which airports do connecting flights from St. Louis to Panama City pass through?

    One-stop flights from St. Louis to Panama City most commonly connect through:

    • Houston George Bush Intcntl (IAH) - 46% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 27% of one-stop connections
    • Miami (MIA) - 20% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 6% of one-stop connections

  • Can I save money by using flexible dates for flights from St. Louis to Panama City?

    Yes. Flexible dates can save you up to 51% on flights from St. Louis to Panama City. Wednesday is the cheapest departure day at $550 round-trip on average, while Sunday is the most expensive at $1,104, a difference of $554.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from St. Louis to Panama City?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 8h 01m, compared with 8h 04m via Miami (MIA) and 9h 41m via Houston George Bush Intcntl (IAH).

  • What popular places can I visit in Panama City?

    Some of the most popular sights in Panama City are ATLAPA Conventions Center, Panama Old Cathedral and Veneto Casino. These are among the most viewed places in Panama City on KAYAK.

Your guide to booking St. Louis to Panama City flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Wednesday departure and avoid flying on Sunday. On this route, Wednesday flights average $550, about $554 less than Sunday fares (50% savings) based on the last 12 months.
  • If you can choose when to travel, plan your St. Louis to Panama City trip for April. Fares historically average $528 round-trip in that month - typically $491 less than the most expensive month, which is July (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Panama City Tocumen Intl Airport.

    • Riande Aeropuerto Hotel & Casino

More options for your flight from St. Louis to Panama City

Complete your trip to Panama City with a hotel stay or car rental

Car rentals in Panama City
Hotels in Panama City
Vacations in Panama City