STL - PTY

$284 Find Cheap Flights from St. Louis to Panama City - Compare and Save

1 adult
1 adult, Economy, 0 bags

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Everything you should know

Cheapest round-trip
$641
Typical prices: $539-$787
United Airlines
Tue 11/20Fri 12/7
STL - PTY • 1 stop
Cheapest one-way
$284
Typical prices: $236-$348
Multiple Airlines
Fri 10/19
STL - PTY • 1 stop
Nonstop flights
Not available
There are currently no direct flights between St. Louis and Panama City. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
April
Cheapest • 24% price drop
April
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Houston George Bush Intcntl (IAH)
Cheapest • Avg $622 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 8h 00m (one-way)
Insights
Insights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Panama City (STL-PTY)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Panama City

Fri, Nov 20 - Mon, Dec 7
United Airlines Logo
6:15 am - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
12h 23m1 stop Houston George Bush Intcntl
United Airlines Logo
11:35 am - 10:30 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
11h 55m1 stop Houston George Bush Intcntl
$641United Airlines
Fri, Oct 30 - Tue, Nov 3
United Airlines Logo
8:30 am - 6:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
10h 08m1 stop Houston George Bush Intcntl
United Airlines Logo
10:00 am - 9:52 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
12h 52m1 stop Newark
$641United Airlines
Fri, Oct 30 - Tue, Nov 3
Multiple Airlines Logo
6:44 pm - 8:31 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
25h 47m1 stop Atlanta Hartsfield-Jackson
Multiple Airlines Logo
9:31 pm - 5:40 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
21h 09m2 stops Miami Atlanta Hartsfield-Jackson
$643Multiple Airlines
Fri, Oct 30 - Tue, Nov 3
American Airlines Logo
7:10 pm - 1:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
17h 52m2 stops Dallas/Fort Worth Miami
American Airlines Logo
3:13 pm - 8:42 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
18h 29m2 stops Miami New York LaGuardia
$645American Airlines
Fri, Oct 30 - Wed, Nov 4
American Airlines Logo
5:08 pm - 1:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
19h 54m2 stops Washington, D.C. Reagan-National Miami
American Airlines Logo
3:13 pm - 10:53 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
20h 40m2 stops Miami Chicago O'Hare Intl
$645American Airlines
Sun, Oct 4 - Tue, Nov 17
Delta Logo
4:59 pm - 12:58 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
19h 59m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:29 pm - 11:56 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 27m1 stop Atlanta Hartsfield-Jackson
$662Delta
Sun, Oct 4 - Tue, Nov 17
Delta Logo
10:05 am - 12:58 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
26h 53m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:29 pm - 11:56 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 27m1 stop Atlanta Hartsfield-Jackson
$662Delta
Wed, Jan 27 - Tue, Feb 2
Copa Airlines Logo
6:30 am - 8:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
12h 32m1 stop Newark
Copa Airlines Logo
8:55 am - 10:13 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
14h 18m1 stop Houston George Bush Intcntl
$869Copa Airlines
Wed, Jan 27 - Tue, Feb 2
Copa Airlines Logo
6:30 am - 8:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
12h 32m1 stop Newark
Copa Airlines Logo
11:35 am - 10:13 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
11h 38m1 stop Houston George Bush Intcntl
$869Copa Airlines
Tue, Oct 6 - Fri, Nov 13
Avianca Logo
8:30 am - 2:55 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
30h 25m3 stops Washington, D.C. Dulles Intl Guatemala City La Aurora San José Juan Santamaria Intl
Avianca Logo
3:55 pm - 10:12 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
19h 17m2 stops San Salvador El Salvador Intl Washington, D.C. Dulles Intl
$896Avianca
Booking Insights

Price, demand and travel trends for St. Louis to Panama City flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from St. Louis to Panama City with more confidence.

How much is a round-trip flight from St. Louis to Panama City?

Round-trip flights from St. Louis to Panama City start at $641. Prices are typical for this route right now, with typical round-trip fares ranging from $539 to $787. The lowest price found in the past 5 days was $641 on United Airlines.

What's the cheapest day of the week to fly from St. Louis to Panama City?

Wednesday is the cheapest day of the week to fly from St. Louis to Panama City, it is 18% cheaper than the average day. Sunday is the most expensive day with flight prices 26% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from St. Louis to Panama City?

  • April is the cheapest month to fly from St. Louis to Panama City at $503 round-trip.
  • July ($1,019) and June ($796) are the most expensive months.
  • The price difference between flying in the cheapest and most expensive months is 102% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for St. Louis to Panama City flights

Low season

October

Cheapest flight

$284
Best time to beat the crowds with an average 11% drop in price.
Most popular time to fly and prices are also 24% lower on average.
Flight from St. Louis to Panama City

When to book flights from St. Louis to Panama City

Are your dates flexible? Find out the best times to travel from St. Louis to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your St. Louis to Panama City flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from St. Louis to Panama City?

    Flights from St. Louis to Panama City usually depart from Lambert-St Louis (STL) and arrive at Panama City Tocumen Intl (PTY).

  • What cabin classes can I book on flights from St. Louis to Panama City?

    Two cabin classes are available on flights from St. Louis to Panama City:

    • Economy Class
    • Business Class

  • Which airports do connecting flights from St. Louis to Panama City pass through?

    One-stop flights from St. Louis to Panama City most commonly connect through:

    • Houston George Bush Intcntl (IAH) - 43% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 26% of one-stop connections
    • Miami (MIA) - 25% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 5% of one-stop connections

    Houston George Bush Intcntl (IAH) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from St. Louis to Panama City?

    Yes. Being flexible with your travel dates can save you up to 35% on the St. Louis to Panama City route. Wednesday is the cheapest departure day at $550 round-trip on average, while Sunday is the most expensive at $842, a difference of $292. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What popular places can I visit in Panama City?

    Some of the most popular sights in Panama City are Panama City Centre, Avenida Balboa and Multiplaza Pacific. These are among the most viewed places in Panama City on KAYAK.

  • How long is a flight from St. Louis to Panama City?

    A nonstop flight from St. Louis to Panama City takes 0h 00m, covering 2,159 miles.

  • Do I need a passport to fly from St. Louis to Panama City?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • Have flight prices from St. Louis to Panama City changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $641 to $4,665. That means the highest observed fare was about 7x higher than the lowest one.

  • How are flight prices from St. Louis to Panama City looking right now?

    One-way fares from St. Louis to Panama City are currently higher than usual. Average one-way flight prices are about $360, which is 31% above the typical average for this route.

  • How much time can I save by choosing a different layover airport from St. Louis to Panama City?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 8h 00m, compared with 8h 10m via Miami (MIA) and 9h 41m via Houston George Bush Intcntl (IAH).

  • What car rental options are available at Panama City Tocumen Intl Airport (PTY)?

    Panama City Tocumen Intl Airport (PTY) hosts 5 major car rental companies, with daily rates starting from around $1 for economy cars. Top options include:
    • Avis
    • Europcar
    • Ace
    • Budget
    • Hertz

  • How much should I expect to pay for a St. Louis to Panama City flight?

    Round-trip flights from St. Louis to Panama City range from $539 to $787, with an average of $664 over the past 12 months. Anything below $539 counts as a good deal.

Your guide to booking St. Louis to Panama City flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Wednesday departure instead of Sunday. On this route, Wednesday flights average $550 - about $292 less than Sunday (35% savings) based on the last 12 months.
  • If you can choose when to travel, plan your St. Louis to Panama City trip for April. Fares historically average $503 round-trip in that month - typically $516 less than the most expensive month, which is July (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Panama City Tocumen Intl Airport.
    - Riande Aeropuerto Hotel & Casino

More options for your flight from St. Louis to Panama City

Complete your trip to Panama City with a hotel stay or car rental

Car rentals in Panama City
Hotels in Panama City
Vacations in Panama City