STL - PTY

$394 Find Cheap Flights from St. Louis to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Panama City departing on 1/2. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$394
Overall average: $648
United Airlines
Tue 2/17Wed 2/25
STL - PTY • 1 stop
Cheapest one-way
$252
Typical prices: $240-$247
American Airlines
Fri 1/2
STL - PTY • 1 stop
When to book
3 weeks
in advance
Our data shows that travelers who book at least 3 weeks in advance save around 2% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
April
Cheapest • 19% price drop
June
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Panama City (STL-PTY)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Panama City

Tue, Feb 17 - Wed, Feb 25
United Airlines Logo
6:00 am - 5:07 pm
STL
-
PTY
10h 07m1 stop
United Airlines Logo
4:41 pm - 9:23 am
PTY
-
STL
17h 42m1 stop
$394United Airlines
Wed, Apr 29 - Wed, May 6
United Airlines Logo
6:30 am - 6:37 pm
STL
-
PTY
12h 07m2 stops
United Airlines Logo
10:00 am - 10:26 pm
PTY
-
STL
12h 26m1 stop
$398United Airlines
Tue, Jan 27 - Tue, Feb 3
United Airlines Logo
10:07 am - 5:07 pm
STL
-
PTY
30h 00m1 stop
United Airlines Logo
8:55 am - 9:59 pm
PTY
-
STL
14h 04m1 stop
$402United Airlines
Tue, Feb 10 - Sat, Feb 14
United Airlines Logo
6:00 am - 2:45 pm
STL
-
PTY
7h 45m1 stop
United Airlines Logo
4:41 pm - 9:23 am
PTY
-
STL
17h 42m1 stop
$411United Airlines
Tue, Feb 10 - Sat, Feb 14
American Airlines Logo
3:54 pm - 1:27 pm
STL
-
PTY
20h 33m2 stops
American Airlines Logo
4:05 pm - 1:54 pm
PTY
-
STL
22h 49m2 stops
$415American Airlines
Tue, Feb 10 - Sat, Feb 14
United Airlines Logo
10:07 am - 2:45 pm
STL
-
PTY
27h 38m1 stop
United Airlines Logo
4:41 pm - 9:23 am
PTY
-
STL
17h 42m1 stop
$419United Airlines
Fri, Apr 10 - Fri, Apr 17
United Airlines Logo
6:00 am - 6:37 pm
STL
-
PTY
12h 37m1 stop
United Airlines Logo
3:30 pm - 9:28 am
PTY
-
STL
17h 58m1 stop
$428United Airlines
Tue, Feb 17 - Wed, Feb 25
United Airlines Logo
6:25 am - 8:02 pm
STL
-
PTY
12h 37m2 stops
United Airlines Logo
10:00 am - 9:05 pm
PTY
-
STL
12h 05m2 stops
$443United Airlines
Mon, Feb 16 - Mon, Feb 23
United Airlines Logo
6:00 am - 2:45 pm
STL
-
PTY
7h 45m1 stop
United Airlines Logo
8:55 am - 9:23 am
PTY
-
STL
25h 28m1 stop
$448United Airlines
Mon, Feb 16 - Mon, Feb 23
United Airlines Logo
6:55 pm - 5:07 pm
STL
-
PTY
21h 12m2 stops
United Airlines Logo
8:55 am - 9:23 am
PTY
-
STL
25h 28m1 stop
$452United Airlines
Booking Insights

KAYAK's insights & trends for St. Louis to Panama City flights

Get data-powered insights and trends into flights from St. Louis to Panama City to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from St. Louis to Panama City?

The average price of all round-trip flights from St. Louis to Panama City clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from St. Louis to Panama City, look for departures on Tuesdays and avoid leaving on a Sunday, as it's usually the priciest day. When flying back from Panama City, Thursday is the cheapest day to fly and Wednesday is the most expensive.

What is the cheapest month to fly from St. Louis to Panama City?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Panama City is April, where tickets cost $459 (return) on average. On the other hand, the most expensive months are December and February, where the average cost of round-trip tickets is $719 and $648 respectively.

How far in advance should I book a flight from St. Louis to Panama City?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to Panama City, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from St. Louis to Panama City, you should book around 3 weeks before departure, which saves you about 2% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 15 weeks before departure.

Good to know

Low seasonSeptember
Cheapest flight$252
Best time to beat the crowds with an average 10% drop in price.
Most popular time to fly with an average 5% increase in price.
Flight from St. Louis to Panama City

When to book flights from St. Louis to Panama City

Are your dates flexible? Find out the best times to travel from St. Louis to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Panama City

  • What is the cheapest flight from St. Louis to Panama City?

    In the last 3 days, the lowest price for a flight from St. Louis to Panama City was $394 for a round-trip ticket.

  • Do I need a passport to fly between St. Louis and Panama City?

    Yes, you'll most likely have to show a valid passport before boarding the plane in St. Louis and on arrival in Panama City.

  • Which airports will I be using when flying from St. Louis to Panama City?

    St. Louis and Panama City are both served by 1 main airport. You will leave St. Louis from Lambert-St Louis and will be arriving at Panama City Tocumen Intl.

  • Which aircraft models fly most regularly from St. Louis to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from St. Louis to Panama City?

    SkyTeam, oneworld, and Star Alliance are the airline alliances operating flights between St. Louis and Panama City, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from St. Louis to Panama City, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from St. Louis to Panama City are Delta and United Airlines. With an average price for the route of $585 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $560 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from St. Louis to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and PTY can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from St. Louis to Panama City

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8010 reviews
8.1Boarding
8.5Crew
7.9Entertainment
7.9Comfort
7.3Food
Airline reviews

None of the airplane features were available during the flight.

4.0 OkayAnonymous, Dec 2025
JFK - SDQ
Read more Delta reviews

None of the airplane features were available during the flight.

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

Lady Pilot was perfect in every way wheels up to wheels down communication, professionalism, excellent on time departure and on time arrival, excellent communication! Fantastic job with Superb attitude!!

The food is terrible. The staff is wonderful. Comfort is good.

Left on time, a bit delayed due to headwinds most of the trip.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Getting to the flight was arduous and lengthy. The flight itself was good but the food option wasn’t a good selection. I need to do a Kosher option on my return. Flight crew were nice

Good seats in Main cabin, excellent service and excellent landing

My flight was cancelled with no explanation after I had already cleared security. I was given 4 options to rebook, only one being non-stop like I had paid for. I grabbed it. It was 4 plus hours later and then took off even later. Biggest complaint is that I booked early and had an aisle seat. They gave me a "window" seat in front of the exit row, so the seat did not decline. I weigh all of 103 #s and it was tight for me! For what I paid, I feel I was kind of ripped off. I think they should have given me the empty comfort seat for the inconvenience. There was no apology nor any explanation as to why the flight was cancelled. My guess is it benefitted Delta in some way.

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

The flight was on time. I generally don’t drink or eat on short flights and the seats were good and the flight attendants were friendly. That’s all I expect

It was nice to have gotten up upgraded to first class with a meal on a three hour flight

Not great experience - we were super late boarding due to issues with aircraft. Then when we finally all got onboard and seated and they started taxiing out to the runway they just stopped then turned around and went back to the airport. Apparently the crew “ran out of time” to legally fly us. They mentioned that they were about 2 minutes away from taking off. I understand the rules and safety but kinda wonder why they would have bothered boarding us in the first place? Had to go all the way back and de plane and then wait in a HUGE line to get a hotel (this is somewhere around 2:30am) finally got to hotel by Uber (no shuttle after 20min so gave up) and they ended up putting us all back on the same aircraft at 10am next morning so got about 2.5 hours sleep. They did give us. $250 credit, but it was a São Paulo Brazil flight out of Dulles. The flight and everything was fine.

United overall experience is great these days. Airport experience was very organized. Staff on flight were great. App and information as good as it gets.

United have really come back. Airport and boarding process is clear and good, app and information also very good

They charged a fee for 1st bag checked. Others in same party were free.

Flight was delayed 8 times. We were sitting at the airport for 14 hours. We got 2 hours of sleep (if that) on what was not meant to be a red-eye.

The movies offered were great. Staff were very pleasant and very efficient.

After a delay at the gate, C3, at Ohare on Sunday, I left my Blk ski coat on the bench at the gate, lost! Please review my lob claim, thx.

Very bad! They kept delaying my flight and wouldn’t do anything about it

Gate was overcrowded. Gate agents performed very well. Flight crew was top notch! Efficient & professional & courteous. Both meals not thermalized well. Dinner main dish was actually cold in the center. Almost inedible. Breakfast sandwich was lukewarm.

The boarding was as always, the crew tried their best but not enough. The food was a disaster I had dietary restrictions that were half met because the company did not loaded the food for the flight. The entertainment screen was fine but content was not and also they removed the free messaging option from the flight and they charged 30 dollars for that crappy bandwidth. This flight is not worth the cost and the company is going down on quality.

Not comparable to Qatar Airways services on flights to Doha. Flight attendants provided basic services; I was never recognized by name or as an Executive Platinum member. Restrooms were not kept clean during the flight.

Awful. They won’t help me with anything. I booked on American but they abdicated to Iberia. The ticket was overpriced. Everything negative

it was fine, decent flight... dont get food besides cookies or pretzels so not sure why you ask about food. same for entertainment..

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

I got sick nothing contagious but distressing enough and the care I received on the flight was astounding.

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

A little late at the start but all worked out well.

Everything you need to know for your flight from St. Louis to Panama City

Information on your arrival and departure airports