PTY - STL

$314 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$656
Overall average: $567
United Airlines
Sun 9/6Thu 9/10
PTY - STL • 2 stops
Cheapest one-way
$314
Multiple Airlines
Sat 5/9
PTY - STL • 3 stops
Top airlines
United Airlines
Cheapest • from $656 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Miami (MIA)
Cheapest • Avg $567 (round-trip)
Atlanta (ATL)
Shortest trip • 8h 26m (one-way)
Insights
Insights
Insights
Insights
When to travel
March
Cheapest • 37% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
10:00 am - 12:30 am
PTY
-
STL
14h 30m
2 stops
United Airlines Logo
6:00 am - 6:37 pm
STL
-
PTY
12h 37m
2 stops
$656United Airlines
Sat, May 16 - Tue, May 19
American Airlines Logo
1:49 pm - 10:53 pm
PTY
-
STL
9h 04m
1 stop
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$675American Airlines
Thu, May 7 - Tue, May 12
United Airlines Logo
7:55 am - 10:45 pm
PTY
-
STL
14h 50m
2 stops
United Airlines Logo
7:09 pm - 4:12 pm
STL
-
PTY
21h 03m
2 stops
$677United Airlines
Thu, May 7 - Tue, May 12
American Airlines Logo
1:49 pm - 10:24 pm
PTY
-
STL
8h 35m
1 stop
American Airlines Logo
11:06 am - 12:46 pm
STL
-
PTY
25h 40m
1 stop
$679American Airlines
Sat, May 16 - Tue, May 19
American Airlines Logo
1:49 pm - 8:30 am
PTY
-
STL
18h 41m
2 stops
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$680American Airlines
Thu, May 7 - Tue, May 12
American Airlines Logo
1:49 pm - 11:47 am
PTY
-
STL
21h 58m
2 stops
American Airlines Logo
4:30 pm - 12:46 pm
STL
-
PTY
20h 16m
2 stops
$683American Airlines
Sat, May 16 - Tue, May 19
Delta Logo
2:15 pm - 11:59 pm
PTY
-
STL
9h 44m
1 stop
Delta Logo
6:00 am - 12:50 pm
STL
-
PTY
6h 50m
1 stop
$693Delta
Sat, May 16 - Tue, May 19
American Airlines Logo
1:49 pm - 11:47 am
PTY
-
STL
21h 58m
2 stops
American Airlines Logo
3:42 pm - 12:46 pm
STL
-
PTY
21h 04m
2 stops
$701American Airlines
Wed, May 13 - Sat, May 16
United Airlines Logo
10:00 am - 10:30 pm
PTY
-
STL
12h 30m
1 stop
United Airlines Logo
6:00 am - 6:37 pm
STL
-
PTY
12h 37m
1 stop
$708United Airlines
Wed, May 13 - Sat, May 16
United Airlines Logo
7:55 am - 10:45 pm
PTY
-
STL
14h 50m
2 stops
United Airlines Logo
10:14 am - 6:37 pm
STL
-
PTY
8h 23m
1 stop
$712United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Panama City to St. Louis?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Panama City to St. Louis departing in September.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is March, where tickets cost $360 (return) on average. On the other hand, the most expensive months are November and January, where the average cost of round-trip tickets is $706 and $704 respectively.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$314
Best time to beat the crowds with an average 2% drop in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $314 for a one-way ticket and $656 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9538 reviews
7.3Comfort
8.1Crew
7.7Boarding
6.6Food
7.1Entertainment
Airline reviews

Food was awful. TV didn’t work for long haul flight and my husband needed credit. Staff was nice and did their best but overall conditions were very uncomfortable.

4.0 OkayAnonymous, Apr 2026
NRT - EWR
Read more United Airlines reviews

Food was awful. TV didn’t work for long haul flight and my husband needed credit. Staff was nice and did their best but overall conditions were very uncomfortable.

It was perfect! I've never flown with United before, but I definitely will in the future

I had a cancelled flight because of technical issues going to my destination, and a delayed flight coming home. All told it wasn’t a total bust.

Just a bad day to fly. Flight was delayed from scheduled 6:50 pm departure to 8:50 pm. Combination of factors mostly related to weather at the destination airport (which is where the incoming flight originated) which delayed the inbound flight over an hour. Once on board, we taxied but had to hold again on the taxiway for 10 minutes or so. We did not get wheels up until after 9 pm. The flight was smooth but about 18 minutes from our destination, we had to hold for several minutes more due to weather at ORD. We finally landed at ORD about 11:08 pm (accounting for the time difference, that was about a 3 hour delay from our scheduled departure time). It felt like we were never going to get to our destination. But the flight crew and attendants were very good. The movie selection onboard was also very nice. Got to watch half of a movie just during our taxi from the gate at ATL due to the delay!

I liked that it was on time, however, the food was not good.

Fine. The issues I had were associated with luggage being delayed from Turkey to Tanzania

They were fast and I like how they used to entertainment system to play video about the safety.

No meal service to the back of the plane as it started late or was too slow to get it out before it was time to land.

Terrible, if possible won't be flying again anytime soon!

Efficient boarding and early departure. Very smooth flight. Early arrival in ATL. Great flight.

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports

Panama City (PTY)
St. Louis (STL)