PTY - STL

$329 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 5/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$624
Overall average: $667
Delta
Thu 5/7Tue 5/12
PTY - STL • 1 stop
Cheapest one-way
$329
Multiple Airlines
Wed 5/6
PTY - STL • 2 stops
Top airlines
Delta
Cheapest • from $624 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Miami (MIA)
Cheapest • Avg $567 (round-trip)
Atlanta (ATL)
Shortest trip • 8h 15m (one-way)
Insights
Insights
Insights
Insights
When to travel
March
Cheapest • 37% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Thu, May 7 - Tue, May 12
Delta Logo
2:15 pm - 11:59 pm
PTY
-
STL
9h 44m
1 stop
Delta Logo
6:00 am - 12:50 pm
STL
-
PTY
6h 50m
1 stop
$624Delta
Thu, May 7 - Mon, May 11
American Airlines Logo
1:49 pm - 10:24 pm
PTY
-
STL
8h 35m
1 stop
American Airlines Logo
2:12 pm - 12:46 pm
STL
-
PTY
22h 34m
2 stops
$626American Airlines
Thu, May 7 - Tue, May 12
American Airlines Logo
1:49 pm - 10:16 am
PTY
-
STL
20h 27m
1 stop
American Airlines Logo
11:06 am - 12:46 pm
STL
-
PTY
25h 40m
1 stop
$632American Airlines
Thu, May 7 - Tue, May 12
United Airlines Logo
7:55 am - 10:30 pm
PTY
-
STL
14h 35m
1 stop
United Airlines Logo
7:45 am - 6:37 pm
STL
-
PTY
10h 52m
2 stops
$634United Airlines
Thu, May 7 - Mon, May 11
American Airlines Logo
1:49 pm - 10:24 pm
PTY
-
STL
8h 35m
1 stop
American Airlines Logo
11:06 am - 12:46 pm
STL
-
PTY
25h 40m
1 stop
$635American Airlines
Fri, May 1 - Fri, May 8
American Airlines Logo
1:49 pm - 10:24 pm
PTY
-
STL
8h 35m
1 stop
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$643American Airlines
Fri, May 1 - Fri, May 8
American Airlines Logo
1:49 pm - 3:05 pm
PTY
-
STL
25h 16m
2 stops
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$648American Airlines
Sat, May 16 - Tue, May 19
Delta Logo
2:15 pm - 11:59 pm
PTY
-
STL
9h 44m
1 stop
Delta Logo
6:00 am - 12:50 pm
STL
-
PTY
6h 50m
1 stop
$650Delta
Sat, May 16 - Tue, May 19
American Airlines Logo
1:49 pm - 10:53 pm
PTY
-
STL
9h 04m
1 stop
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$654American Airlines
Sat, May 30 - Sun, Jun 21
United Airlines Logo
10:55 pm - 3:46 pm
PTY
-
STL
16h 51m
2 stops
United Airlines Logo
8:15 pm - 4:12 pm
STL
-
PTY
19h 57m
2 stops
$656United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is March, where tickets cost $360 (return) on average. On the other hand, the most expensive months are November and January, where the average cost of round-trip tickets is $706 and $704 respectively.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$329
Best time to beat the crowds with an average 2% drop in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $329 for a one-way ticket and $624 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9452 reviews
8.1Crew
7.1Entertainment
7.3Comfort
6.6Food
7.7Boarding
Airline reviews

Good quick flight on a small but comfortable plane. I'm 6'3 and had plenty of space.

8.0 ExcellentMatthew, Mar 2026
IAD - CMH
Read more United Airlines reviews

Good quick flight on a small but comfortable plane. I'm 6'3 and had plenty of space.

Offered to check carry on to final destination. This is the most absurd thing in the world. I'm carrying on because I need what is in the carry-on. I'm okay with picking up at next stop but then I will be on much larger plane that can accommodate it. Also, if there is ever a change to your flight. Go to the airport and have the people there fix your ticket. Don't do it over the phone or online with United they screwed us up and ended up with flights for our last leg that took off before our first leg.

The economy seats on the 777 was not as cramped as I had feared, but the food was terrible.

Experience was great - no complaints. Took off on time, landed early. Got to the gate relatively quickly - took a little bit of extra time to deplane but nothing excessive.

Economy plus was so cramped I could not use my laptop. It was beyond bad.

OK, we were delayed and had to de plane and reboard.

United is one airline which regardless of how many separate United tickets in existence, if one flight breaks down, the airline will take care of all the flights.

Both our flights were delayed. Almost didn’t get in the second flight. Staff was rude to the bone.

Hopped on time for the flight only to get deplaned and delayed another 2.5 hours.

Terrible experience! delay 2 time and say i dont have ticket

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports

Panama City (PTY)
St. Louis (STL)