PTY - STL

$311 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 3/31. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$573
Typical prices: $407-$606
United Airlines
Sat 5/30Tue 6/2
PTY - STL • 2 stops
Cheapest one-way
$311
Typical prices: $329-$403
Multiple Airlines
Tue 3/31
PTY - STL • 3 stops
Top airlines
United Airlines
Cheapest • from $573 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
June
Cheapest • 35% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Sat, May 30 - Tue, Jun 2
United Airlines Logo
10:55 pm - 3:21 pm
PTY
-
STL
16h 26m
2 stops
United Airlines Logo
8:50 am - 4:12 pm
STL
-
PTY
7h 22m
1 stop
$573United Airlines
Wed, Feb 25 - Tue, Mar 3
United Airlines Logo
4:41 pm - 3:38 pm
PTY
-
STL
23h 57m
1 stop
United Airlines Logo
6:25 am - 8:02 pm
STL
-
PTY
12h 37m
2 stops
$581United Airlines
Wed, Mar 18 - Sun, Mar 22
American Airlines Logo
3:10 pm - 10:32 am
PTY
-
STL
19h 22m
1 stop
American Airlines Logo
6:20 pm - 12:40 pm
STL
-
PTY
18h 20m
1 stop
$587American Airlines
Tue, Feb 24 - Tue, Mar 3
United Airlines Logo
4:41 pm - 9:23 am
PTY
-
STL
17h 42m
1 stop
United Airlines Logo
6:00 am - 5:07 pm
STL
-
PTY
10h 07m
1 stop
$590United Airlines
Wed, Mar 18 - Sun, Mar 22
American Airlines Logo
3:10 pm - 12:44 pm
PTY
-
STL
21h 34m
2 stops
American Airlines Logo
6:57 pm - 12:40 pm
STL
-
PTY
17h 43m
2 stops
$592American Airlines
Tue, Feb 24 - Tue, Mar 3
United Airlines Logo
4:41 pm - 9:23 am
PTY
-
STL
17h 42m
1 stop
United Airlines Logo
6:25 am - 7:38 pm
STL
-
PTY
12h 13m
2 stops
$594United Airlines
Mon, Feb 23 - Sun, Mar 1
United Airlines Logo
4:41 pm - 10:14 pm
PTY
-
STL
30h 33m
1 stop
United Airlines Logo
6:00 am - 2:45 pm
STL
-
PTY
7h 45m
1 stop
$602United Airlines
Wed, Feb 25 - Tue, Mar 3
American Airlines Logo
2:40 pm - 1:43 pm
PTY
-
STL
24h 03m
2 stops
American Airlines Logo
3:49 pm - 1:40 pm
STL
-
PTY
20h 51m
2 stops
$618American Airlines
Thu, Mar 12 - Thu, Mar 19
United Airlines Logo
3:41 pm - 10:36 am
PTY
-
STL
18h 55m
2 stops
United Airlines Logo
6:00 am - 6:38 pm
STL
-
PTY
12h 38m
1 stop
$675United Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
7:55 am - 8:21 pm
PTY
-
STL
12h 26m
1 stop
United Airlines Logo
8:50 am - 6:37 pm
STL
-
PTY
9h 47m
1 stop
$684United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is June, where tickets cost $362 (return) on average. On the other hand, the most expensive months are January and July, where the average cost of round-trip tickets is $664 and $659 respectively.

Good to know

Low seasonApril
Cheapest flight$277
Best time to beat the crowds with an average 3% drop in price.
Most popular time to fly with an average 12% increase in price.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $311 for a one-way ticket and $573 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9205 reviews
7.1Entertainment
7.3Comfort
7.7Boarding
6.6Food
8.1Crew
Airline reviews

HORRIBLE, my initial flight was cancelled, they made me pay $200 extra dollars and that got cancelled as well! After 6 cancellations I decided to get a refund because I needed to get home to my babies. Out of $1000+ dollars they offered me only $40 in refund! Totally unacceptable! The flight that they cancelled I was able to fly it on another airline. I had to spend $400 on one way tickets just to get home! I’m still getting the runaround.

2.0 MediocreSonje’, Jan 2026
STL - EWR
Read more United Airlines reviews

HORRIBLE, my initial flight was cancelled, they made me pay $200 extra dollars and that got cancelled as well! After 6 cancellations I decided to get a refund because I needed to get home to my babies. Out of $1000+ dollars they offered me only $40 in refund! Totally unacceptable! The flight that they cancelled I was able to fly it on another airline. I had to spend $400 on one way tickets just to get home! I’m still getting the runaround.

First class ticket gets you a choice of chips or nuts. . Just like economy Southwest. Also no screen in the seats. This is first class???!

Seated dude next to me even though lots of empty rows. But main thing was we sat on the tarmac after landing for 30 minutes because of, in the words of the dude who sat next to me, “operational incompetence”. We got changing directions about where to pick up gate checked bags. Pilot and flight attendant were awesome though.

It was a pretty standard flight... until the almost hour and a half spent on the taxi way. I get that the weather has been poor but the delay had nothing to do with the weather and more to do with a plane with several issues tying up the gate. I get that that happens from time to time but this has been EVERY flight I've been on for the past 5 years and I fly 3 to 5 times a year. This isn't just United... it's American, it's Delta. It's an issue with the entire industry. I work for UPS and packages on a cargo plane get better service than people do these days. Anymore I HATE flying.

I so appreciate the crew members on each flight of United. They are outstanding.

Flight arrived 30 min early and bag was waiting at the baggage pickup. United Club HNL was one of the nicest in the system

Unfortunately weather delayed our flight waiting for our plane to arrive and due to a little snow time was needed to deice the plane so departure was very delayed and I missed the connecting flight

Mean flight attendant. I wanted to reuse my plastic cup, but he (Matthew) said he can't for safety. I then said "I don't want water then" and he poured me a glass. I hope Matthew gets herpes and spends the rest of his life poor, lonely, and homeless.

Very good. Because of the delays with my previous flight, I missed my connection, but I was able to book another flight through the United app easily.

It was great. There were some issues prior to takeoff. The weather was poor so we had to go through deicing, and we were delayed a bit by the pilots' concern about one of the engines, but that's aviation. The pilots handled everything with aplomb, and kept us apprised

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports