PTY - STL

$300 Find Cheap Flights from Panama City to St. Louis - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 8/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$680
Typical prices: $515-$673
American Airlines
Fri 10/16Mon 10/26
PTY - STL • 1 stop
Cheapest one-way
$300
Typical prices: $386-$477
Multiple Airlines
Mon 8/3
PTY - STL • 3 stops
Top airlines
American Airlines
Cheapest • from $680 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Miami (MIA)
Cheapest • Avg $567 (round-trip)
Miami (MIA)
Shortest trip • 8h 28m (one-way)
Insights
Insights
Insights
Insights
When to travel
March
Cheapest • 41% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Fri, Oct 16 - Mon, Oct 26
American Airlines Logo
3:35 pm - 11:15 pm
PTY
-
STL
7h 40m
1 stop
American Airlines Logo
6:28 pm - 2:00 pm
STL
-
PTY
19h 32m
2 stops
$680American Airlines
Tue, Aug 11 - Wed, Aug 26
United Airlines Logo
3:30 pm - 10:10 am
PTY
-
STL
18h 40m
1 stop
United Airlines Logo
5:30 pm - 2:14 pm
STL
-
PTY
20h 44m
2 stops
$688United Airlines
Fri, Oct 16 - Mon, Oct 26
American Airlines Logo
3:35 pm - 11:15 pm
PTY
-
STL
7h 40m
1 stop
American Airlines Logo
6:08 pm - 2:00 pm
STL
-
PTY
19h 52m
1 stop
$690American Airlines
Thu, Aug 6 - Mon, Aug 17
United Airlines Logo
7:55 am - 10:45 pm
PTY
-
STL
14h 50m
1 stop
United Airlines Logo
6:15 am - 2:14 pm
STL
-
PTY
7h 59m
1 stop
$697United Airlines
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
3:30 pm - 3:38 pm
PTY
-
STL
24h 08m
2 stops
United Airlines Logo
8:00 am - 7:31 pm
STL
-
PTY
11h 31m
2 stops
$699United Airlines
Thu, Aug 6 - Mon, Aug 17
United Airlines Logo
10:55 pm - 12:11 pm
PTY
-
STL
13h 16m
2 stops
United Airlines Logo
8:50 am - 4:04 am
STL
-
PTY
19h 14m
2 stops
$701United Airlines
Thu, Oct 29 - Sun, Nov 1
United Airlines Logo
7:55 am - 10:20 pm
PTY
-
STL
14h 25m
1 stop
United Airlines Logo
6:15 am - 2:45 pm
STL
-
PTY
7h 30m
1 stop
$708United Airlines
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
3:30 pm - 10:10 am
PTY
-
STL
18h 40m
1 stop
United Airlines Logo
8:00 am - 7:31 pm
STL
-
PTY
11h 31m
2 stops
$709United Airlines
Thu, Oct 29 - Sun, Nov 1
United Airlines Logo
9:30 am - 8:48 am
PTY
-
STL
23h 18m
2 stops
United Airlines Logo
6:15 am - 2:45 pm
STL
-
PTY
7h 30m
1 stop
$712United Airlines
Sun, Aug 2 - Mon, Aug 31
United Airlines Logo
7:55 am - 5:42 pm
PTY
-
STL
9h 47m
1 stop
United Airlines Logo
8:00 am - 4:04 am
STL
-
PTY
20h 04m
2 stops
$720United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is March, where tickets cost $360 (return) on average. On the other hand, the most expensive months are May and June, where the average cost of round-trip tickets is $877 and $773 respectively.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$300
Best time to beat the crowds with an average 7% drop in price.
Most popular time to fly and prices are also 21% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 5 days, the lowest price for a flight from Panama City to St. Louis was $300 for a one-way ticket and $680 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9896 reviews
7.7Boarding
7.1Entertainment
8.1Crew
7.3Comfort
6.6Food
Airline reviews

It was terrible. sat on airplane 2 hours then flight was canceled. made to pick up bags and go through Panama immagration to rebook another flight. worst experice ever at a airport.

10.0 ExcellentJeff, Apr 2026
PTY - IAH
Read more United Airlines reviews

It was terrible. sat on airplane 2 hours then flight was canceled. made to pick up bags and go through Panama immagration to rebook another flight. worst experice ever at a airport.

Crew was tired as we all were. Pretty abrupt. Flight was delayed. Not as enjoyable as the other 3 legs we flew.

Airport terminal was outdated, flight was on a small jet with no wifi

Good until I was put on air canada flight Houston Vancouver not even one cookie

Excellent flight. Smooth, efficient boarding. Quick flight. Arrived early at STL.

Where the plane landed and the next grate to get to is a LONG LONG LONG walk again if one is not fit and healthy with no carts to assist. It sucks

More racist flight attandants maybe because i sm an attracticted darkskin latino man but once again bad flight attamdants they ignored me the whole flight even the woman sitting next to me notice how rude they were towards me i really never want to fly united or american airlines they alawsys have the rudesslt and racist flight attandants

The fight didn’t happen because I was rerouted to Trinidad as previously explained.

The check in from Panama to Houston was good. From Houston to Toronto was definitely an experience. The Pilot from Houston to Toronto was exceptional. He probably saved our lives by noticing a dent in the fuselage. Everyone was taken off the plane and we boarded a new plane

Last minute gate change nearly caused us to miss our flight. Change was not announced or displayed in the main board at the old gate. Terrible communication. When we landed we had to wait 20 minutes because there was another plane at the assigned gate. Not the crew’s fault, but adding 20 minutes to a 45 minute flight sucked.

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports

Panama City (PTY)
St. Louis (STL)