PTY - STL

$613 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$613
Typical prices: $684-$579
Multiple Airlines
Thu 5/7Tue 5/12
PTY - STL • 1 stop
Cheapest one-way
$414
Multiple Airlines
Wed 4/15
PTY - STL • 3 stops
Top airlines
Cheapest • from $656 (round-trip)
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
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Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $567 (round-trip)
Shortest trip • 8h 26m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 37% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Thu, May 7 - Tue, May 12
Multiple Airlines Logo
7:09 pm - 2:39 pm
PTY
-
STL
19h 30m
1 stop
Multiple Airlines Logo
6:00 am - 2:01 pm
STL
-
PTY
8h 01m
1 stop
$613Multiple Airlines
Sun, Sep 6 - Thu, Sep 10
Delta Logo
2:28 pm - 11:37 pm
PTY
-
STL
9h 09m
1 stop
Delta Logo
6:00 am - 12:56 pm
STL
-
PTY
6h 56m
1 stop
$656Delta
Thu, May 7 - Tue, May 12
American Airlines Logo
1:49 pm - 10:24 pm
PTY
-
STL
8h 35m
1 stop
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$665American Airlines
Thu, May 7 - Tue, May 12
American Airlines Logo
1:49 pm - 8:24 am
PTY
-
STL
18h 35m
2 stops
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$669American Airlines
Thu, May 7 - Tue, May 12
American Airlines Logo
1:49 pm - 10:16 am
PTY
-
STL
20h 27m
1 stop
American Airlines Logo
11:06 am - 12:46 pm
STL
-
PTY
25h 40m
1 stop
$675American Airlines
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
10:00 am - 12:30 am
PTY
-
STL
14h 30m
2 stops
United Airlines Logo
6:00 am - 6:37 pm
STL
-
PTY
12h 37m
2 stops
$677United Airlines
Thu, May 7 - Tue, May 12
American Airlines Logo
1:49 pm - 8:54 am
PTY
-
STL
19h 05m
2 stops
American Airlines Logo
5:53 pm - 12:46 pm
STL
-
PTY
18h 53m
2 stops
$679American Airlines
Thu, May 7 - Tue, May 12
American Airlines Logo
1:49 pm - 10:16 am
PTY
-
STL
20h 27m
1 stop
American Airlines Logo
8:03 pm - 12:46 pm
STL
-
PTY
16h 43m
2 stops
$680American Airlines
Sat, May 16 - Tue, May 19
Delta Logo
2:15 pm - 9:38 pm
PTY
-
STL
7h 23m
1 stop
Delta Logo
6:00 am - 12:50 pm
STL
-
PTY
6h 50m
1 stop
$693Delta
Sat, May 16 - Tue, May 19
American Airlines Logo
1:49 pm - 10:53 pm
PTY
-
STL
9h 04m
1 stop
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$697American Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Panama City to St. Louis?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Panama City to St. Louis departing in May.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is March, where tickets cost $360 (return) on average. On the other hand, the most expensive months are November and January, where the average cost of round-trip tickets is $706 and $704 respectively.

Good to know

Low seasonSeptember
Cheapest flight$414
Best time to beat the crowds with an average 1% drop in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $337 for a one-way ticket and $613 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9554 reviews
7.3Comfort
7.7Boarding
8.1Crew
6.6Food
7.1Entertainment
Airline reviews

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

10.0 ExcellentCorrine, Apr 2026
MCW - ORD
Read more United Airlines reviews

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

After arriving in Chicago, we were taxiing for 1.5 hours with infrequent and untruthful updates about the amount of time it would take to arrive at the gate. Minimally, the team could have provided timing expectations that were more truthful, especially one their original expectations were not met.

The crew was generally professional. Though one of the crew members seemed to be easily annoyed, the others were fine and helpful. The green olives and almonds snack was really good. A great idea, and nice balance of tastes.

It as confusing with the connections and I almost missed my next flight because of the first delay with the first flight. United could have helped passengers go through immigration quicker rather than waiting with everyone else. The flight attendants were super friendly and lovely. The vegetarian food was awful- I did not finish. I would suggest they just do pasta next time

Flights were on time actually early service was good and crew cheerful

Every staff member was professional, friendly and courteous. The pizza twist was ok. It was warm but too much dough.

I had a terrible experience. My flight got delayed from Atlanta to Chicago on Monday April 6, 2026, and that led to me missing my next flight to Brussels. United Airlines didn’t provide me with any accommodation for shelter. I had to sleep at the airport in Chicago. The next flight I was put on didn’t leave until the evening hours of Tuesday 4/7/2026.

Boarding was again a "free for all". We were boarding group 4, and almost the entire plane was able to board before us. It's a shame that someone who follows the rules, gets the short end of the stick. Not fair.

Food and drink service was very low quality. The flight attendants in business class must have been short some staff. Service was sluggish and not much English was spoken

Flight left on time, arrived early, pleasant staff provided water, coffee, etc. access to bathrooms was reasonable and were well maintained. blankets were available, lots of entertainment options. LUGGAGE SERVICE WAS GREAT. I got my one checked bag quickly and was able to make a bus connection for a 2 hour bus ride saving me from waiting another 1.5 hours.

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports