PTY - STL

$320 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 5/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$624
Typical prices: $678-$446
Delta
Thu 5/14Mon 8/10
PTY - STL • 1 stop
Cheapest one-way
$320
Multiple Airlines
Sat 5/9
PTY - STL • 3 stops
Top airlines
Delta
Cheapest • from $624 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Miami (MIA)
Cheapest • Avg $567 (round-trip)
Atlanta (ATL)
Shortest trip • 8h 26m (one-way)
Insights
Insights
Insights
Insights
When to travel
March
Cheapest • 37% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Thu, May 14 - Mon, Aug 10
Delta Logo
2:15 pm - 11:59 pm
PTY
-
STL
9h 44m
1 stop
Delta Logo
6:00 am - 1:13 pm
STL
-
PTY
7h 13m
1 stop
$624Delta
Thu, May 14 - Mon, Aug 10
American Airlines Logo
1:49 pm - 11:47 am
PTY
-
STL
21h 58m
2 stops
American Airlines Logo
8:00 pm - 2:20 pm
STL
-
PTY
18h 20m
2 stops
$629American Airlines
Tue, May 12 - Tue, May 19
American Airlines Logo
1:49 pm - 10:24 pm
PTY
-
STL
8h 35m
1 stop
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$643American Airlines
Tue, May 12 - Tue, May 19
American Airlines Logo
1:49 pm - 11:09 am
PTY
-
STL
21h 20m
2 stops
American Airlines Logo
3:42 pm - 12:46 pm
STL
-
PTY
21h 04m
2 stops
$648American Airlines
Sat, May 16 - Tue, May 19
Delta Logo
2:15 pm - 11:59 pm
PTY
-
STL
9h 44m
1 stop
Delta Logo
6:00 am - 12:50 pm
STL
-
PTY
6h 50m
1 stop
$650Delta
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
10:00 am - 12:30 am
PTY
-
STL
14h 30m
2 stops
United Airlines Logo
8:35 am - 6:37 pm
STL
-
PTY
10h 02m
1 stop
$656United Airlines
Sat, May 16 - Tue, May 19
American Airlines Logo
1:49 pm - 10:53 pm
PTY
-
STL
9h 04m
1 stop
American Airlines Logo
3:42 pm - 12:46 pm
STL
-
PTY
21h 04m
2 stops
$659American Airlines
Sat, May 16 - Tue, May 19
American Airlines Logo
1:49 pm - 10:53 pm
PTY
-
STL
9h 04m
1 stop
American Airlines Logo
5:24 am - 12:46 pm
STL
-
PTY
7h 22m
1 stop
$675American Airlines
Sun, May 10 - Sun, May 17
United Airlines Logo
7:55 am - 10:30 pm
PTY
-
STL
14h 35m
1 stop
United Airlines Logo
7:09 pm - 2:14 pm
STL
-
PTY
19h 05m
2 stops
$677United Airlines
Sat, May 16 - Tue, May 19
American Airlines Logo
1:49 pm - 8:27 am
PTY
-
STL
18h 38m
2 stops
American Airlines Logo
3:42 pm - 12:46 pm
STL
-
PTY
21h 04m
2 stops
$680American Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Panama City to St. Louis?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Panama City to St. Louis departing in May.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is March, where tickets cost $360 (return) on average. On the other hand, the most expensive months are November and January, where the average cost of round-trip tickets is $706 and $704 respectively.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$320
Best time to beat the crowds with an average 2% drop in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $320 for a one-way ticket and $624 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9509 reviews
8.1Crew
6.6Food
7.3Comfort
7.7Boarding
7.1Entertainment
Airline reviews

Wonderful in-seat entertainment with seatback screens and huge selection of quality movies. The ability to bluetooth connect headphones was amazing.

10.0 ExcellentBryan, Mar 2026
DEN - SFO
Read more United Airlines reviews

Wonderful in-seat entertainment with seatback screens and huge selection of quality movies. The ability to bluetooth connect headphones was amazing.

Smooth and easy boarding, comfortable for the entire 5 hour flight, and the seat back entertainment was great! I appreciated all the features, from location info and maps, movies, the ability to connect with Bluetooth headphones, and good selection of movies. Food was good, normal airline snacks (I didn’t purchase anything)

we did a return flight from Paris CDG to SFO. This trip was much better than the departing flight SFO to CDG. The food was better quality, the crew was nicer, and the interior of the plane seemed cleaner.

They promise free wi-fi prior to boarding and then once on board you are informed you have to purchase wifi even after being a mileagePlus member.

I've been flying American mostly, and it's been very frustrating. This united flight makes me realize maybe the issue isn't flying, but the airline. United was a significantly better experience. The plane was more comfortable, with a normal amount of leg room (vs the ridiculous reductions AA has made), more comfortable seats, screens to watch movies. It was a much better experience!

Awful. No counter attendants. No dinner offered due to delays.

Horrible service no Wi-Fi connection on both leg of the flight and they are refusing to fix bad service

3 hour delay…. Nearly 2 hours sitting on tarmac. Do better, United. Or at least have the sense to not say “we hope you enjoyed your flight with us” upon disembarking.

Flights were on time. Free Wifi on plane. Everything was well organized.

During landing. 2 crew members passed 3 times by my lane and didn't notice that people in front of us had their site to the furthermore reclined... That was uncomfortable and could have been dangerous.

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports

Panama City (PTY)
St. Louis (STL)