PTY - STL

$693 Find Cheap Flights from Panama City to St. Louis - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$693
Typical prices: $687-$787
United Airlines
Sat 1/27Wed 1/31
PTY - STL • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
February
Cheapest • 25% price drop
November
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Miami (MIA)
Cheapest • Avg $715 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 8h 12m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Wed, Jan 27 - Sun, Jan 31
United Airlines Logo
4:41 pm - 9:31 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
17h 50m1 stop Houston George Bush Intcntl
United Airlines Logo
6:45 pm - 5:12 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
21h 27m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
$693United Airlines
Wed, Jan 27 - Sun, Jan 31
United Airlines Logo
10:00 am - 11:20 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
14h 20m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
5:06 pm - 2:45 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
20h 39m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
$693United Airlines
Wed, Jan 27 - Sun, Jan 31
United Airlines Logo
4:41 pm - 2:06 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
22h 25m1 stop Houston George Bush Intcntl
United Airlines Logo
5:59 pm - 5:12 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
22h 13m1 stop Houston George Bush Intcntl
$710United Airlines
Thu, Feb 25 - Mon, Mar 1
United Airlines Logo
11:35 am - 10:25 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
11h 50m1 stop Houston George Bush Intcntl
United Airlines Logo
6:00 am - 8:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
13h 02m1 stop Newark
$710United Airlines
Wed, Nov 18 - Thu, Nov 26
Delta Logo
3:29 pm - 11:56 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 2:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
7h 02m1 stop Atlanta Hartsfield-Jackson
$808Delta
Thu, Nov 19 - Sun, Nov 22
Multiple Airlines Logo
6:10 pm - 11:59 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
30h 49m3 stops Bogotá El Dorado San Salvador El Salvador Intl Orlando
Multiple Airlines Logo
5:15 pm - 1:20 amSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
31h 05m3 stops Las Vegas Harry Reid Intl Orlando Bogotá El Dorado
$1,120Multiple Airlines
Wed, Nov 18 - Thu, Nov 26
Multiple Airlines Logo
10:05 am - 6:39 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
33h 34m3 stops Bogotá El Dorado Miami Atlanta Hartsfield-Jackson
Multiple Airlines Logo
9:09 am - 2:10 amSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
16h 01m2 stops Dallas/Fort Worth San Salvador El Salvador Intl
$1,232Multiple Airlines
Wed, Nov 18 - Thu, Nov 26
Multiple Airlines Logo
10:05 am - 6:39 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
33h 34m3 stops Bogotá El Dorado Miami Atlanta Hartsfield-Jackson
Multiple Airlines Logo
6:09 pm - 1:20 amSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
30h 11m3 stops Orlando Baltimore/Washington Bogotá El Dorado
$1,242Multiple Airlines
Wed, Nov 18 - Sun, Nov 22
Multiple Airlines Logo
2:30 am - 11:16 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
21h 46m2 stops Bogotá El Dorado Orlando
Multiple Airlines Logo
6:05 pm - 3:15 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
20h 10m3 stops Orlando Baltimore/Washington Bogotá El Dorado
$1,689Multiple Airlines
Booking Insights

Price, demand and travel trends for Panama City to St. Louis flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Panama City to St. Louis?

Round-trip flights from Panama City to St. Louis typically range from $687 to $787. The lowest price found in the past 5 days was $693, on United Airlines.

What’s the cheapest month to fly from Panama City to St. Louis?

•February is the cheapest month to fly from Panama City to St. Louis at $559 round-trip.
•June ($976) and July ($918) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 74% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Panama City to St. Louis flights

Low season

August

Cheapest flight

$693
Beat the crowds with an average 77% drop in travelers.
The most popular month to fly with an average 126% increase in travelers.
Round-trip flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Panama City to St. Louis flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Panama City to St. Louis?

    Only Economy Class is available on flights from Panama City to St. Louis.

  • How long is a flight from Panama City to St. Louis?

    A nonstop flight from Panama City to St. Louis takes 00m, covering 2,159 miles.

  • Do I need a passport to fly from Panama City to St. Louis?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Panama City to St. Louis flight?

    Round-trip flights from Panama City to St. Louis range from $687 to $787, with an average of $743 over the past 12 months. Anything below $687 counts as a good deal.

  • Have flight prices from Panama City to St. Louis changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $693 to $1,689. That means the highest observed fare was about 2x higher than the lowest one.

  • What car rental options are available at Lambert-St Louis Airport (STL)?

    Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates averaging $77 for economy cars. Top options include:

    • Hertz
    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Payless

  • Which airports can I use when flying from Panama City to St. Louis?

    Flights from Panama City to St. Louis usually depart from Panama City Tocumen Intl (PTY) and arrive at Lambert-St Louis (STL).

  • Which airports do connecting flights from Panama City to St. Louis pass through?

    One-stop flights from Panama City to St. Louis most commonly connect through:

    • Houston George Bush Intcntl (IAH) - 54% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 32% of one-stop connections
    • Miami (MIA) - 14% of one-stop connections

  • Can I save money by using flexible dates for flights from Panama City to St. Louis?

    Yes. Flexible dates can save you up to 23% on flights from Panama City to St. Louis. Tuesday is the cheapest departure day at $687 round-trip on average, while Monday is the most expensive at $883, a difference of $196.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Panama City to St. Louis?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 8h 12m, compared with 8h 56m via Houston George Bush Intcntl (IAH) and 11h 52m via Miami (MIA).

  • What is the time difference between Panama City and St. Louis?

    St. Louis is 1 hour behind Panama City (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in St. Louis?

    Some of the most popular sights in St. Louis are Busch Stadium, Enterprise Center and America's Center Convention Complex. These are among the most viewed places in St. Louis on KAYAK.

Your guide to booking Panama City to St. Louis flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Tuesday departure and avoid flying on Monday. On this route, Tuesday flights average $687, about $196 less than Monday fares (22% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Panama City to St. Louis trip for February. Fares historically average $559 round-trip in that month - typically $417 less than the most expensive month, which is June (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Lambert-St Louis Airport.

    • Renaissance St. Louis Airport Hotel
    • Drury Inn & Suites St. Louis Airport
    • DoubleTree by Hilton St. Louis Airport

More options for your flight from Panama City to St. Louis

Complete your trip to St. Louis with a hotel stay or car rental

Car rentals in St. Louis
Hotels in St. Louis
Vacations in St. Louis