$349 Find Cheap Flights from Panama City to St. Louis - Compare and Save

Only Economy Class is available on flights from Panama City to St. Louis.

A nonstop flight from Panama City to St. Louis takes 00m, covering 2,159 miles.

Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

Round-trip flights from Panama City to St. Louis range from $687 to $787, with an average of $743 over the past 12 months. Anything below $687 counts as a good deal.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $630 to $2,373. That means the highest observed fare was about 4x higher than the lowest one.

One-way fares from Panama City to St. Louis are currently lower than usual. Average one-way flight prices are about $445, which is 10% below the typical average for this route.

Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates averaging $77 for economy cars. Top options include:

• Hertz
• Budget
• Alamo
• Enterprise Rent-A-Car
• Payless

Flights from Panama City to St. Louis usually depart from Panama City Tocumen Intl (PTY) and arrive at Lambert-St Louis (STL).

One-stop flights from Panama City to St. Louis most commonly connect through:

• Houston George Bush Intcntl (IAH) - 54% of one-stop connections
• Atlanta Hartsfield-Jackson (ATL) - 32% of one-stop connections
• Miami (MIA) - 14% of one-stop connections

Yes. Flexible dates can save you up to 23% on flights from Panama City to St. Louis. Tuesday is the cheapest departure day at $687 round-trip on average, while Monday is the most expensive at $883, a difference of $196.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 8h 12m, compared with 8h 56m via Houston George Bush Intcntl (IAH) and 11h 52m via Miami (MIA).

St. Louis is 1 hour behind Panama City (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

Some of the most popular sights in St. Louis are Busch Stadium, Enterprise Center and America's Center Convention Complex. These are among the most viewed places in St. Louis on KAYAK.