PTY - STL

$340 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$570
Overall average: $556
United Airlines
Wed 8/26Mon 8/31
PTY - STL • 2 stops
Cheapest one-way
$340
Typical prices: $310-$384
United Airlines
Wed 4/1
PTY - STL • 2 stops
Top airlines
United Airlines
Cheapest • from $570 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Miami (MIA)
Cheapest • Avg $567 (round-trip)
Atlanta (ATL)
Shortest trip • 8h 15m (one-way)
Insights
Insights
Insights
Insights
When to travel
June
Cheapest • 36% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Wed, Aug 26 - Mon, Aug 31
United Airlines Logo
3:20 pm - 12:20 pm
PTY
-
STL
21h 00m
2 stops
United Airlines Logo
8:15 pm - 6:37 pm
STL
-
PTY
22h 22m
2 stops
$570United Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
3:30 pm - 10:07 am
PTY
-
STL
18h 37m
1 stop
United Airlines Logo
6:14 am - 6:37 pm
STL
-
PTY
12h 23m
1 stop
$601United Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
3:30 pm - 10:34 am
PTY
-
STL
19h 04m
2 stops
United Airlines Logo
5:41 pm - 4:12 pm
STL
-
PTY
22h 31m
2 stops
$605United Airlines
Thu, Apr 2 - Sun, Apr 5
United Airlines Logo
7:55 am - 4:08 pm
PTY
-
STL
8h 13m
1 stop
United Airlines Logo
4:49 pm - 4:12 pm
STL
-
PTY
23h 23m
1 stop
$613United Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
3:30 pm - 10:07 am
PTY
-
STL
18h 37m
1 stop
United Airlines Logo
6:14 am - 4:12 pm
STL
-
PTY
9h 58m
1 stop
$622United Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
3:30 pm - 12:11 pm
PTY
-
STL
20h 41m
2 stops
United Airlines Logo
8:35 am - 6:37 pm
STL
-
PTY
10h 02m
1 stop
$626United Airlines
Thu, Mar 26 - Thu, Apr 2
American Airlines Logo
1:40 pm - 8:51 am
PTY
-
STL
19h 11m
2 stops
American Airlines Logo
11:22 am - 3:01 pm
STL
-
PTY
27h 39m
1 stop
$640American Airlines
Thu, Mar 26 - Thu, Apr 2
American Airlines Logo
3:10 pm - 10:32 am
PTY
-
STL
19h 22m
1 stop
American Airlines Logo
6:20 pm - 3:01 pm
STL
-
PTY
20h 41m
1 stop
$649American Airlines
Mon, Jun 29 - Sat, Jul 4
United Airlines Logo
7:55 am - 5:42 pm
PTY
-
STL
9h 47m
1 stop
United Airlines Logo
11:10 am - 6:37 pm
STL
-
PTY
7h 27m
1 stop
$778United Airlines
Thu, Apr 2 - Sun, Apr 5
Multiple Airlines Logo
10:10 am - 3:25 pm
PTY
-
STL
29h 15m
3 stops
Multiple Airlines Logo
4:05 pm - 1:30 pm
STL
-
PTY
21h 25m
2 stops
$1,024Multiple Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is June, where tickets cost $362 (return) on average. On the other hand, the most expensive months are January and July, where the average cost of round-trip tickets is $704 and $679 respectively.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$340
Most popular time to fly and prices are also 2% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $340 for a one-way ticket and $570 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9377 reviews
6.6Food
7.1Entertainment
7.7Boarding
8.1Crew
7.3Comfort
Airline reviews

It’s always a great time flying with united airlines.

10.0 ExcellentCollins, Mar 2026
BOS - DEN
Read more United Airlines reviews

It’s always a great time flying with united airlines.

Good flight. Efficient boarding and competent flight crew. No problems until we arrived at our destination gate. We were early so there was an aircraft at the gate that had to move before we could pull in. Then, due to the type of aircraft we flew, the cabin door could not be opened until some luggage from the cargo bay was offloaded to preserve center of gravity characteristics. So, that further delayed deplaning. Despite being 20 minutes early on landing, we ended up being 5 to 10 minutes late after all the delays.

It was amazing. I had several upgraded seats on my flight out. Everything went smooth with no delays.

They never clean the toilet, and the food is worse

Everything went well except the turbulence what no one have a control of but pilot and crew handled very good!

There was no WiFi available, there were mechanical problems with the plane and we landed at C 124, then the gate was switched to A 26, then all the way back to C126! For a 75 yo woman traveling alone, this was a difficult journey, indeed!

This trip did not start off well. The inbound flight was delayed about 20 minutes. Then, after initial onboarding, the passengers had to deplane due to a mechanical problem. That took about 30 minutes to fix and be cleared. Then, reboarding was chaotic. It took a long time to sort passengers and two passengers on standby were ticketed but there was no seat. So, they had to deplane. One of the flight crew was trying to help passengers figure out a place to put their carry-on bags and that took more time. In the end, our scheduled 10:30 am departure did not actually take off until about 12:05 pm CST. The flight itself was long but we got to Houston. Some passengers missed their connecting flights and had to rebook. Not the best of flights I've had.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Complimentary light meal would be appreciated. But great flight crew service on all legs

Poor. Crew allowed children to run around and scream and disturb passanger’s seats.

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports

Panama City (PTY)
St. Louis (STL)