PTY - STL

$301 Find Cheap Flights from Panama City to St. Louis - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 8/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$672
Typical prices: $252-$697
Multiple Airlines
Tue 7/14Tue 7/21
PTY - STL • 2 stops
Cheapest one-way
$301
Typical prices: $386-$477
Multiple Airlines
Sun 8/30
PTY - STL • 3 stops
Top airlines
American Airlines
Cheapest • from $680 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Miami (MIA)
Cheapest • Avg $567 (round-trip)
Miami (MIA)
Shortest trip • 8h 28m (one-way)
Insights
Insights
Insights
Insights
When to travel
March
Cheapest • 41% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Tue, Jul 14 - Tue, Jul 21
Multiple Airlines Logo
10:25 am - 8:57 am
PTY
-
STL
22h 32m
2 stops
Multiple Airlines Logo
6:34 pm - 8:34 pm
STL
-
PTY
26h 00m
1 stop
$672Multiple Airlines
Fri, Oct 16 - Mon, Oct 26
American Airlines Logo
3:35 pm - 1:03 pm
PTY
-
STL
21h 28m
2 stops
American Airlines Logo
6:28 pm - 2:00 pm
STL
-
PTY
19h 32m
2 stops
$680American Airlines
Thu, Aug 6 - Mon, Aug 17
United Airlines Logo
7:55 am - 5:42 pm
PTY
-
STL
9h 47m
1 stop
United Airlines Logo
12:27 pm - 4:04 am
STL
-
PTY
15h 37m
1 stop
$686United Airlines
Fri, Oct 16 - Mon, Oct 26
American Airlines Logo
3:35 pm - 11:15 pm
PTY
-
STL
7h 40m
1 stop
American Airlines Logo
6:08 pm - 2:00 pm
STL
-
PTY
19h 52m
1 stop
$690American Airlines
Thu, Aug 6 - Mon, Aug 17
United Airlines Logo
10:55 pm - 12:11 pm
PTY
-
STL
13h 16m
2 stops
United Airlines Logo
9:30 am - 4:04 am
STL
-
PTY
18h 34m
2 stops
$691United Airlines
Sat, Aug 29 - Mon, Aug 31
Delta Logo
2:30 pm - 11:31 pm
PTY
-
STL
9h 01m
1 stop
Delta Logo
6:00 am - 12:55 pm
STL
-
PTY
6h 55m
1 stop
$699Delta
Thu, Aug 6 - Tue, Aug 18
United Airlines Logo
7:55 am - 5:42 pm
PTY
-
STL
9h 47m
1 stop
United Airlines Logo
6:15 am - 2:14 pm
STL
-
PTY
7h 59m
1 stop
$708United Airlines
Sun, Sep 6 - Thu, Sep 10
United Airlines Logo
10:55 pm - 12:02 pm
PTY
-
STL
13h 07m
2 stops
United Airlines Logo
8:00 am - 7:31 pm
STL
-
PTY
11h 31m
2 stops
$709United Airlines
Thu, Aug 6 - Tue, Aug 18
United Airlines Logo
3:30 pm - 10:34 am
PTY
-
STL
19h 04m
2 stops
United Airlines Logo
7:25 am - 6:37 pm
STL
-
PTY
11h 12m
2 stops
$712United Airlines
Thu, Oct 29 - Sun, Nov 1
United Airlines Logo
7:55 am - 10:20 pm
PTY
-
STL
14h 25m
1 stop
United Airlines Logo
6:15 am - 2:45 pm
STL
-
PTY
7h 30m
1 stop
$718United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is March, where tickets cost $360 (return) on average. On the other hand, the most expensive months are May and June, where the average cost of round-trip tickets is $877 and $773 respectively.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$301
Best time to beat the crowds with an average 7% drop in price.
Most popular time to fly and prices are also 21% lower on average.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 5 days, the lowest price for a flight from Panama City to St. Louis was $301 for a one-way ticket and $680 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9868 reviews
7.3Comfort
6.6Food
7.7Boarding
7.1Entertainment
8.1Crew
Airline reviews

Lost one piece of luggage even though I checked in 2.5 hours before the flight

6.0 Goodmerrill, Jun 2026
SFO - MCO
Read more United Airlines reviews

Lost one piece of luggage even though I checked in 2.5 hours before the flight

The crew was the worst ive ever had in my life flying with United Airlines, letting another person move my bag without asking and then the staff saying would the floor be better after I kept begging saying dont move my bag it has fragile things inside. This incident truly makes me they favor other customers more and I dont want to worry about being on the tail end. Especially if they dont listen any input, no care for what I asked but accommodated those who are reckless and disturb others more...

For the expense of first class, the seats could have been nicer and higher tier snacks would have been nice.

The boarding process on the departure from LA was rather slow even though I was in Group 1. For first class, I was not expecting to have to pay for Wi-fi but I did and then the wi-fi was spotty. The entree was surprisingly good and so that was a pleasant surprise. However, once I got to Houston, it was terrible. Unfortunately there was bad weather but the constant gate changes for my connecting flight was difficult to manage due to having to navigate back and forth between different terminals.

United has been holding my money for a cancel on another ticket they wouldn’t let me fly for going on 5 months. Terrible service I wouldn’t choose to buy tickets or fly with united again. Very bad experience generally dishonorable and poor service .

The seats were very nice in premium economy. The service was good. The flight was slightly bumpy. Would have appreciated more updates from the pilots.

They delayed the flight 3 hours because it wasn't full they moved us to 5 different gates probably the worst airline ever not even spirit is this bad.

Very easy ! Use the kiosk and bag drop and right to security within 10 min

Checking bag at terminal was horrible. No agents to check us in and only 1 kiosk working. Boarding went ok. Crew onboard was very scattered rained. Missed our row while serving and then didn’t see them hardly again.

Crew was amazing, takeoff wonderful. The bathroom was disgusting from before takeoff the odor made the flight uncomfortable as you could smell the bathroom from the center of the plane where we were sitting. Smelled like raw sewage. My daughter was throwing up as we landed due to the smell and horrible turbulence as we approached Newark.

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports

Panama City (PTY)
St. Louis (STL)