PTY - STL

$312 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 9/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Wed, Jan 28 - Mon, Feb 16
United Airlines Logo
4:40 pm - 2:18 pmPTY-STL
22h 38m2 stops
United Airlines Logo
6:15 am - 2:45 pmSTL-PTY
7h 30m1 stop
$515United Airlines
Find Deal
Wed, Jan 28 - Sat, Feb 21
Delta Logo
3:27 pm - 3:01 pmPTY-STL
24h 34m1 stop
Delta Logo
10:00 am - 8:04 pmSTL-PTY
9h 04m1 stop
$537Delta
Find Deal
Wed, Jan 28 - Fri, Feb 20
United Airlines Logo
4:40 pm - 2:18 pmPTY-STL
22h 38m2 stops
United Airlines Logo
6:45 am - 7:38 pmSTL-PTY
11h 53m2 stops
$580United Airlines
Find Deal
Sat, Sep 13 - Sat, Oct 11
United Airlines Logo
3:30 pm - 9:57 amPTY-STL
18h 27m1 stop
United Airlines Logo
6:15 am - 6:37 pmSTL-PTY
12h 22m1 stop
$610United Airlines
Find Deal
Sat, Sep 13 - Sat, Oct 11
American Airlines Logo
3:31 pm - 9:26 amPTY-STL
17h 55m2 stops
American Airlines Logo
8:00 pm - 2:03 pmSTL-PTY
18h 03m2 stops
$614American Airlines
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Mon, Sep 8 - Tue, Sep 23
American Airlines Logo
3:31 pm - 3:37 pmPTY-STL
24h 06m2 stops
American Airlines Logo
5:28 am - 12:55 pmSTL-PTY
7h 27m1 stop
$617American Airlines
Find Deal
Wed, Jan 28 - Mon, Feb 16
United Airlines Logo
4:40 pm - 12:20 pmPTY-STL
20h 40m2 stops
United Airlines Logo
6:45 am - 7:38 pmSTL-PTY
11h 53m2 stops
$722United Airlines
Find Deal
Fri, Sep 12 - Sat, Oct 11
 Logo
3:25 am - 5:52 pmPTY-STL
14h 27m2 stops
 Logo
9:20 am - 12:10 amSTL-PTY
14h 50m2 stops
$1,593
Find Deal
Sun, Sep 7 - Tue, Sep 23
 Logo
3:20 am - 6:10 pmPTY-STL
14h 50m2 stops
 Logo
10:21 am - 7:23 pmSTL-PTY
9h 02m1 stop
$1,609
Find Deal
Tue, Jan 27 - Thu, Feb 19
Avianca Logo
2:55 am - 6:33 pmPTY-STL
16h 38m2 stops
Avianca Logo
5:18 pm - 8:50 amSTL-PTY
14h 32m2 stops
$4,702Avianca
Find Deal
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Panama City to St. Louis?

The average price of all round-trip flights from Panama City to St. Louis clicked on KAYAK for each day over the last 12 months.

When flying from Panama City to St. Louis, you should consider leaving on a Thursday and avoid Wednesdays if you are looking for the best rates. For your return to Panama City, you’ll find the best rates on Tuesdays and the most expensive ones on Sundays.

Good to know

Low seasonFebruary
Cheapest flight$312
Best time to beat the crowds with an average 41% drop in price.
Most popular time to fly with an average 13% increase in price.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $312 for a one-way ticket and $515 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between Panama City and St. Louis, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Panama City to St. Louis, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Panama City to St. Louis are Delta and United Airlines. With an average price for the route of $558 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $598 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7982 reviews
7.3Food
7.9Entertainment
8.2Boarding
7.9Comfort
8.5Crew
Airline reviews

Three seats in first class were broken and while they were able to still acommodate us it was looking very touch and go and they had others they could not acommodate

6.0 GoodKristopher, Aug 2025HPN - ATL
Read more Delta reviews

Three seats in first class were broken and while they were able to still acommodate us it was looking very touch and go and they had others they could not acommodate

Mechanic delay in addition to a 2 hour change in takeoff time was frustrating.

Delayed due to thunderstorms and no in-flight service due to rough weather — both of which are out of Delta’s control. Flight was good overall.

The flight attendants in SLC were rude. I arrived 40 minutes early to gate. Ticket said I needed check in for seat assignments and tried check in and attendants said they weren’t doing it. And proceeded to never call me to give me a ticket so when time to board I received the very last seat. Please relay to employees to do their job better..,

On this flight I felt the food offering was not as complete as on previous flights. The tomato salad was a bit off and there was nothing additional such a bread or butter. The breakfast was only one option, so you either ate what they had or ate nothing. The crew was efficient, but most seemed frustrated throughout the flight. The flight arrived early and was obstacle-free, so I’m overall quite happy, but the shine in the rest of the experience just wasn’t there.

Our seats were comfortable with adequate room to stretch out and recline. The food was tasty and served it just the right intervals. Our flight attendant was extra attentive and friendly. Flight arrived early. And the most turbulence. Overall that’s good and experience for an 11 hour flight as can be hoped for

The seats got pretty uncomfortable pretty fast. The armrests are bigger than on other planes, so I had less room in the actual seat. My butt hurt by the end of the flight. :/ comfort was the primary issue. The crew were fantastic!

I believe that a four-hour trip should have a meal. Delta had none.

Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!

I was uncomfortably cold on the plane. Other than that it was uneventful and therefore as enjoyable as a plane ride can be.

I understand stuff happens, but plane failures are likely due to lack of maintenance. Additionally, air conditioning wasn't working, no snack/drink service, no WiFi. Fortunately, the crew was communicative and light-hearted. United grabbed another plane and we were able to get to our destination.

There was no food available for this red eye... one little waffle cookie for a 6+ hour flight... thank God I was able to sleep some

It is clear that someone knew, and competent, is in charge of food at United Airlines at least for the international flights. I was flying in coach, but the choices of the dinner were excellent. Tasty, and appropriate size. I had the beef, which was a little bit like a shepherds pie, and it was good. Nothing comparable has been served on a United flight in years. It will not be confused with three star food, but it is very good for airline food. Even better was the breakfast choice between a cinnamon roll and a breakfast sandwich. I chose the breakfast sandwich which was absolutely delicious and which I would happily order again at my local Starbucks or Panera. It is clear that someone knew indifferent is in charge of the food and it’s about time.

The flight was comfortable with the exit row and great service

Had to cancel first flight because Airporter Bus took over 3 hrs to get to airport which resulted in an extra $378 dollar fare . Is there anyway I can be reimbursed for initial fare since it was not my fault? Sent from my iPhone EJ Ledet

For both flights I requested a gluten free meal, they didn’t have one nor were there other options.

Plane was crowded and even when we hit altitude, the plane was hot, not enough air flow.

Flight attendant in first class gave poor service (like he didn't want to be there) and food was awful. We sat waiting for gate upon arrival over 45 mins.

The experience was great, the crew was very polite and hospitable. I will definitely make if my go to airlines.

Inoperable monitor left no entert for 9 hours. Crew was not helpful Food was awful.

Everything you need to know for your flight from Panama City to St. Louis

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