PTY - STL

$281 Find Cheap Flights from Panama City to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 3/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$591
Overall average: $679
Copa Airlines
Wed 7/8Wed 7/15
PTY - STL • 1 stop
Cheapest one-way
$281
Typical prices: $321-$342
Multiple Airlines
Mon 3/30
PTY - STL • 3 stops
Top airlines
Copa Airlines
Cheapest • from $591 (round-trip)
United Airlines
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Miami (MIA)
Cheapest • Avg $567 (round-trip)
Atlanta (ATL)
Shortest trip • 8h 15m (one-way)
Insights
Insights
Insights
Insights
When to travel
June
Cheapest • 34% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Wed, Jul 8 - Wed, Jul 15
Copa Airlines Logo
3:30 pm - 10:07 am
PTY
-
STL
18h 37m
1 stop
Copa Airlines Logo
6:01 am - 4:04 am
STL
-
PTY
22h 03m
1 stop
$591Copa Airlines
Wed, Apr 8 - Wed, Apr 15
United Airlines Logo
7:55 am - 10:56 pm
PTY
-
STL
15h 01m
2 stops
United Airlines Logo
6:00 am - 2:14 pm
STL
-
PTY
8h 14m
1 stop
$592United Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
3:30 pm - 10:07 am
PTY
-
STL
18h 37m
1 stop
United Airlines Logo
6:14 am - 4:12 pm
STL
-
PTY
9h 58m
1 stop
$601United Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
10:55 pm - 12:11 pm
PTY
-
STL
13h 16m
2 stops
United Airlines Logo
5:41 pm - 2:14 pm
STL
-
PTY
20h 33m
2 stops
$605United Airlines
Tue, Mar 17 - Tue, Jun 16
United Airlines Logo
3:41 pm - 9:21 am
PTY
-
STL
17h 40m
1 stop
United Airlines Logo
11:10 am - 6:37 pm
STL
-
PTY
7h 27m
1 stop
$613United Airlines
Tue, Mar 17 - Thu, Jun 11
United Airlines Logo
7:55 am - 9:21 am
PTY
-
STL
25h 26m
1 stop
United Airlines Logo
8:15 pm - 4:12 pm
STL
-
PTY
19h 57m
2 stops
$634United Airlines
Wed, Jul 8 - Wed, Jul 15
United Airlines Logo
10:55 pm - 3:46 pm
PTY
-
STL
16h 51m
2 stops
United Airlines Logo
5:41 pm - 4:12 pm
STL
-
PTY
22h 31m
2 stops
$686United Airlines
Tue, Mar 17 - Thu, Jun 11
American Airlines Logo
3:10 pm - 11:58 pm
PTY
-
STL
8h 48m
1 stop
American Airlines Logo
5:15 am - 12:14 pm
STL
-
PTY
6h 59m
1 stop
$726American Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
7:55 am - 10:45 pm
PTY
-
STL
14h 50m
1 stop
United Airlines Logo
6:14 am - 6:37 pm
STL
-
PTY
12h 23m
1 stop
$812United Airlines
Tue, Mar 17 - Tue, Jun 9
Multiple Airlines Logo
9:45 am - 3:29 pm
PTY
-
STL
29h 44m
3 stops
Multiple Airlines Logo
2:20 pm - 5:00 pm
STL
-
PTY
26h 40m
3 stops
$847Multiple Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is June, where tickets cost $362 (return) on average. On the other hand, the most expensive months are January and July, where the average cost of round-trip tickets is $704 and $679 respectively.

Find deals

Good to know

Low seasonSeptember
Cheapest flight$281
Best time to beat the crowds but there is an average 3% increase in price.
Most popular time to fly with an average 14% increase in price.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 3 days, the lowest price for a flight from Panama City to St. Louis was $281 for a one-way ticket and $591 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9345 reviews
8.1Crew
7.7Boarding
7.3Comfort
7.1Entertainment
6.6Food
Airline reviews

Given I (and I’m assuming most people) have both carry in and a personal item included in their fare, I find it very unfair that on neither of my flights I was able to use the overhead for my small backpack because they were completely rammed with luggage, people personal items, jackets, hats and other items. So the only item I brought in had to be stuffed under my seat while they had their leg room and sat comfortable with all of their items in the overhead. This has to stop because I was uncomfortable on both flights when I only had one smaller item that could not be checked due to its contents (medication etc). Plenty of people could have checked theirs but chose not to and then took up the space allotment for 2 people.

8.0 ExcellentAnonymous, Feb 2026
YEG - IAH
Read more United Airlines reviews

Given I (and I’m assuming most people) have both carry in and a personal item included in their fare, I find it very unfair that on neither of my flights I was able to use the overhead for my small backpack because they were completely rammed with luggage, people personal items, jackets, hats and other items. So the only item I brought in had to be stuffed under my seat while they had their leg room and sat comfortable with all of their items in the overhead. This has to stop because I was uncomfortable on both flights when I only had one smaller item that could not be checked due to its contents (medication etc). Plenty of people could have checked theirs but chose not to and then took up the space allotment for 2 people.

Flight left on time and we arrived 25 minutes early! There was a gate available when we arrived so early on a busy Sunday afternoon! Flight attendants came around twice with the drinks cart.

Wonderful. Quick boarding. Early departure and we arrived 30 minutes early at our destination. Unfortunately, when you arrive early, there is still a departing aircraft at our gate. We had to park for 30 minutes until the gate was clear. So our early arrival was not really early at the gate. Otherwise it was a quick and smooth flight. Appreciated the efficiency.

I couldn’t make my first flight due to weather delays trapping us in the town we were in. Then I had to buy a new ticket

Flight attendants had a little attitude. Food tastes no good.

Chargers didn’t work, no entertainment and we had to wait for taxiing for easily 40 minutes after arriving early. Bags were late too!

Everything was great except for the boarding process. Everyone is lining up all at the same time and it’s hard to tell between the groups as they are way too large.

Women boarding passengers at the gate was absolutely rude and disrespectful of passengers. The flight attendant was absolutely delightful! Smiling and connected with the passengers. So happy. The seats are cramped and uncomfortable but I guess that’s just the way it is Communication regarding flight was excellent

Overall we had a good experience during our flight from San Francisco to Houston.

Airport terminal was outdated, flight was on a small jet with no wifi

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports

Panama City (PTY)
St. Louis (STL)