PTY - STL

$341 Find Cheap Flights from Panama City to St. Louis - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to St. Louis departing on 9/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$666
Typical prices: $671-$312
Delta
Tue 8/11Tue 8/18
PTY - STL • 1 stop
Cheapest one-way
$341
Typical prices: $315-$390
Multiple Airlines
Thu 9/3
PTY - STL • 3 stops
Top airlines
Cheapest • from $666 (round-trip)
Best reviews • 7.4 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $567 (round-trip)
Shortest trip • 8h 28m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 40% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Tue, Aug 11 - Tue, Aug 18
Delta Logo
2:20 pm - 11:21 pm
PTY
-
STL
9h 01m
1 stop
Delta Logo
6:00 am - 12:55 pm
STL
-
PTY
6h 55m
1 stop
$666Delta
Wed, Nov 4 - Fri, Jan 8
American Airlines Logo
2:43 pm - 10:32 pm
PTY
-
STL
8h 49m
1 stop
American Airlines Logo
7:03 am - 3:38 pm
STL
-
PTY
7h 35m
1 stop
$687American Airlines
Tue, Aug 11 - Tue, Aug 18
American Airlines Logo
1:39 pm - 10:39 am
PTY
-
STL
21h 00m
1 stop
American Airlines Logo
3:25 pm - 12:39 pm
STL
-
PTY
21h 14m
2 stops
$691American Airlines
Wed, Nov 4 - Fri, Jan 8
American Airlines Logo
2:43 pm - 12:37 pm
PTY
-
STL
22h 54m
2 stops
American Airlines Logo
5:15 am - 3:38 pm
STL
-
PTY
9h 23m
1 stop
$692American Airlines
Sun, Sep 6 - Thu, Sep 10
Delta Logo
2:20 pm - 11:31 pm
PTY
-
STL
9h 11m
1 stop
Delta Logo
6:00 am - 12:56 pm
STL
-
PTY
6h 56m
1 stop
$699Delta
Sun, Sep 6 - Thu, Sep 10
Delta Logo
2:20 pm - 11:31 pm
PTY
-
STL
9h 11m
1 stop
Delta Logo
6:00 am - 12:56 pm
STL
-
PTY
6h 56m
1 stop
$709Delta
Fri, Jul 24 - Mon, Jul 27
American Airlines Logo
1:14 pm - 2:05 pm
PTY
-
STL
24h 51m
2 stops
American Airlines Logo
5:13 pm - 12:14 pm
STL
-
PTY
19h 01m
2 stops
$713American Airlines
Wed, Oct 28 - Sat, Jan 9
American Airlines Logo
3:35 pm - 11:15 pm
PTY
-
STL
7h 40m
1 stop
American Airlines Logo
6:09 pm - 3:38 pm
STL
-
PTY
20h 29m
1 stop
$720American Airlines
Wed, Oct 28 - Sat, Jan 9
American Airlines Logo
3:35 pm - 12:55 pm
PTY
-
STL
21h 20m
2 stops
American Airlines Logo
5:59 pm - 1:27 pm
STL
-
PTY
18h 28m
2 stops
$724American Airlines
Fri, Jul 24 - Fri, Jul 31
American Airlines Logo
1:14 pm - 8:34 am
PTY
-
STL
19h 20m
2 stops
American Airlines Logo
6:13 pm - 12:14 pm
STL
-
PTY
18h 01m
2 stops
$733American Airlines
Booking Insights

KAYAK's insights & trends for Panama City to St. Louis flights

Get data-powered insights and trends into flights from Panama City to St. Louis to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Panama City to St. Louis?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Panama City to St. Louis departing in August.

What is the cheapest month to fly from Panama City to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to St. Louis is March, where tickets cost $360 (return) on average. On the other hand, the most expensive months are May and June, where the average cost of round-trip tickets is $825 and $773 respectively.

Good to know

Low seasonSeptember
Cheapest flight$341
Best time to beat the crowds with an average 22% drop in price.
Most popular time to fly with an average 4% increase in price.
Flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Panama City to St. Louis

  • What is the cheapest flight from Panama City to St. Louis?

    In the last 5 days, the lowest price for a flight from Panama City to St. Louis was $341 for a one-way ticket and $666 for a round-trip.

  • Do I need a passport to fly between Panama City and St. Louis?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Panama City and on arrival in St. Louis.

  • Which airports will I be using when flying from Panama City to St. Louis?

    On your way to St. Louis, you’ll fly out from Panama City Tocumen Intl. You’ll be landing at Lambert-St Louis.

  • Which aircraft models fly most regularly from Panama City to St. Louis?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Panama City to St. Louis?

    Star Alliance is the only airline alliance operating flights between Panama City and St. Louis.

  • How does KAYAK find such low prices on flights from Panama City to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Panama City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Panama City with another airline. Booking your flights between Panama City and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Panama City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Panama City to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9804 reviews
7.7Boarding
8.1Crew
6.6Food
7.3Comfort
7.1Entertainment
Airline reviews

Referencing ANA'S service to Japan and the return on UA, the pillow was awful, the crew was not very attentive, and the food was bizarre and tasted okay. Whoever's idea it was to make vegetable tempera in a steam capsule should probably revisit that. Since it was the vegetarian option, it was my only choice.

6.0 GoodTed, Jun 2026
HND - EWR
Read more United Airlines reviews

Referencing ANA'S service to Japan and the return on UA, the pillow was awful, the crew was not very attentive, and the food was bizarre and tasted okay. Whoever's idea it was to make vegetable tempera in a steam capsule should probably revisit that. Since it was the vegetarian option, it was my only choice.

Crew was great! Good meals. Had room to stretch out

Our flight was delayed 2.5 hours from Lisbon to DC so we missed our connection to Seattle that would have arrived at about 9 PM. The agent initially said we had to stay overnight in DC and there were no other options to put us on to get us to Seattle. While on board I discovered a flight via American he could have put us in but by the time we arrived in DC that was sold out. We were then put on a flight to San Francisco that was also delayed then arrived in San Francisco and our flight to Seattle was also delayed so we ended up not arriving until 2:15 am. Our son could not pick us up so we ended up having to pay over $100 to Uber home. This is the second trip with United that the flight has been delayed causing us to miss an evening in Las Vegas and we were given nothing.

Boarding was smooth and efficient. The only food was some pretzels, but it was a short flight. Not much to order if you were hungry.

Crew were welcoming, accommodating and they worked hard to find places for all carry on.

Packed flight, which makes it tough on crew and boarding staff (and the customers of course). But this was great boarding, clear instructions, etc. Traveling on the weekends are always fraught with danger as you have families and less frequent flyers thus more confusion. But this flight went as planned.

Destroyed my suitcase. Tired of talking about it. Cancelling my unite mileage plus account.

Read the fine print. This was my flight home. I booked my flight for the quickest way home. Had a carry-on and a personal item. Same as my outbound flight. Apparently I needed to pre-pay extra for my carry-on. When I checked in, I was told that I had to check it. I said I’ll pay for it, and was told that this wasn’t an option anymore. They said I still had to pay $50 to check my carry-on. I told them I’ll pay whatever to just carry it in as intended. I was not allowed, so eventually I paid $50 to check my carry-on under a plane that was half full, with overhead compartments that were even less full. My white carry-on suitcase was practically destroyed getting from Idaho falls to Denver to Orange County. The low price air fair was a bait and switch. Got me to the gate, made me pay extra, then didn’t even allow me to pay for a carry on. Not to mention that I paid the $8 for WiFi that didn’t work. All to get my suitcase destroyed. I don’t think I’m going to even keep my Untied mileage plus membership and card. Apparently, membership does not have its privileges for this one.

The flight was delayed, they didn’t even have water for the toilets or for drinks

Even through the flight was delayed due to storms near IAH The flight was great! The crew was so hospitable and professional

Everything you need to know for your flight from Panama City to St. Louis

Information on your arrival and departure airports