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PTY - STL

$356 Find Cheap Flights from Panama City to St. Louis - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$629
Typical prices: $673-$781
United Airlines
Sat 1/27Wed 1/31
PTY - STL • 1 stop
Cheapest one-way
$442
Typical prices: $388-$529
United Airlines
Sat 10/27
PTY - STL • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Panama City and St. Louis. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
February
Cheapest • 25% price drop
November
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Miami (MIA)
Cheapest • Avg $635 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 8h 25m (one-way)
Insights
Insights
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Booking Insights
Flight Deals

Cheap Flights from Panama City to St. Louis (PTY-STL)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to St. Louis

Wed, Jan 27 - Sun, Jan 31
United Airlines Logo
4:41 pm - 9:31 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
17h 50m1 stop Houston George Bush Intcntl
United Airlines Logo
6:45 pm - 5:12 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
21h 27m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
$629United Airlines
Wed, Jan 27 - Sun, Jan 31
United Airlines Logo
11:35 am - 10:35 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
24h 00m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
6:45 pm - 8:02 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
24h 17m2 stops Chicago O'Hare Intl Newark
$629United Airlines
Wed, Jan 27 - Sun, Jan 31
United Airlines Logo
8:55 am - 2:06 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
30h 11m1 stop Houston George Bush Intcntl
United Airlines Logo
10:45 am - 5:12 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
29h 27m1 stop Houston George Bush Intcntl
$645United Airlines
Wed, Jan 27 - Sun, Jan 31
United Airlines Logo
4:41 pm - 4:43 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
25h 02m1 stop Houston George Bush Intcntl
United Airlines Logo
5:59 pm - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
24h 39m1 stop Houston George Bush Intcntl
$645United Airlines
Thu, Nov 19 - Wed, Jan 27
Delta Logo
3:29 pm - 11:56 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
9h 27m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:00 am - 1:55 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
6h 55m1 stop Atlanta Hartsfield-Jackson
$664Delta
Mon, Nov 23 - Thu, Jan 28
Copa Airlines Logo
4:41 pm - 10:02 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
18h 21m1 stop Houston George Bush Intcntl
Copa Airlines Logo
6:15 am - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
12h 23m1 stop Houston George Bush Intcntl
$674Copa Airlines
Mon, Nov 23 - Thu, Jan 28
Copa Airlines Logo
4:41 pm - 8:55 amPTY  Panama City Tocumen Intl-STL Lambert-St Louis
17h 14m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
Copa Airlines Logo
8:30 am - 7:38 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
10h 08m1 stop Houston George Bush Intcntl
$679Copa Airlines
Thu, Nov 19 - Thu, Jan 21
American Airlines Logo
3:34 pm - 5:25 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
26h 51m1 stop Miami
American Airlines Logo
6:08 pm - 3:55 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
20h 47m1 stop Miami
$698American Airlines
Thu, Nov 19 - Thu, Jan 28
American Airlines Logo
3:34 pm - 5:25 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
26h 51m1 stop Miami
American Airlines Logo
6:08 pm - 1:26 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
18h 18m1 stop Miami
$698American Airlines
Thu, Nov 19 - Thu, Jan 28
American Airlines Logo
3:34 pm - 12:44 pmPTY  Panama City Tocumen Intl-STL Lambert-St Louis
22h 10m2 stops Miami Chicago O'Hare Intl
American Airlines Logo
6:00 pm - 3:55 pmSTL  Lambert-St Louis-PTY Panama City Tocumen Intl
20h 55m2 stops Dallas/Fort Worth Miami
$702American Airlines
Booking Insights

Price, demand and travel trends for Panama City to St. Louis flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Panama City to St. Louis?

Round-trip flights from Panama City to St. Louis typically range from $673 to $781. The lowest price found in the past 5 days was $629, on United Airlines.

What’s the cheapest month to fly from Panama City to St. Louis?

•February is the cheapest month to fly from Panama City to St. Louis at $559 round-trip.
•June ($976) and July ($918) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 74% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Panama City to St. Louis flights

Low season

August

Cheapest flight

$442
Beat the crowds with an average 73% drop in travelers.
The most popular month to fly with an average 60% increase in travelers.
One-way flight from Panama City to St. Louis

When to book flights from Panama City to St. Louis

Are your dates flexible? Find out the best times to travel from Panama City to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Panama City to St. Louis flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Panama City to St. Louis?

    Only Economy Class is available on flights from Panama City to St. Louis.

  • How long is a flight from Panama City to St. Louis?

    A nonstop flight from Panama City to St. Louis takes 00m, covering 2,159 miles.

  • Do I need a passport to fly from Panama City to St. Louis?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Panama City to St. Louis flight?

    Round-trip flights from Panama City to St. Louis range from $673 to $781, with an average of $743 over the past 12 months. Anything below $673 counts as a good deal.

  • Have flight prices from Panama City to St. Louis changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $629 to $2,117. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Panama City to St. Louis looking right now?

    One-way fares from Panama City to St. Louis are currently lower than usual. Average one-way flight prices are about $443, which is 7% below the typical average for this route.

  • What car rental options are available at Lambert-St Louis Airport (STL)?

    Lambert-St Louis Airport (STL) hosts 5 major car rental companies, with daily rates starting from around $31 for economy cars. Top options include:

    • Hertz
    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Payless

  • Which airports can I use when flying from Panama City to St. Louis?

    Flights from Panama City to St. Louis usually depart from Panama City Tocumen Intl (PTY) and arrive at Lambert-St Louis (STL).

  • Which airports do connecting flights from Panama City to St. Louis pass through?

    One-stop flights from Panama City to St. Louis most commonly connect through:

    • Houston George Bush Intcntl (IAH) - 61% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 24% of one-stop connections
    • Miami (MIA) - 15% of one-stop connections

  • Can I save money by using flexible dates for flights from Panama City to St. Louis?

    Yes. Flexible dates can save you up to 26% on flights from Panama City to St. Louis. Tuesday is the cheapest departure day at $654 round-trip on average, while Monday is the most expensive at $883, a difference of $229.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Panama City to St. Louis?

    Flying via Miami (MIA) gives the shortest average 1-stop total travel time at 8h 04m, compared with 8h 25m via Atlanta Hartsfield-Jackson (ATL) and 8h 58m via Houston George Bush Intcntl (IAH).

  • What popular places can I visit in St. Louis?

    Some of the most popular sights in St. Louis are Busch Stadium, Enterprise Center and America's Center Convention Complex. These are among the most viewed places in St. Louis on KAYAK.

Your guide to booking Panama City to St. Louis flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Tuesday departure and avoid flying on Monday. On this route, Tuesday flights average $654, about $229 less than Monday fares (26% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Panama City to St. Louis trip for February. Fares historically average $559 round-trip in that month - typically $417 less than the most expensive month, which is June (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Lambert-St Louis Airport.

    • Renaissance St. Louis Airport Hotel
    • Drury Inn & Suites St. Louis Airport
    • DoubleTree by Hilton St. Louis Airport

More options for your flight from Panama City to St. Louis

Complete your trip to St. Louis with a hotel stay or car rental

Car rentals in St. Louis
Hotels in St. Louis
Vacations in St. Louis