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Flight Deals
Cheap Flights from St. Louis to South Carolina
Cheapest round-trip prices found by our users on KAYAK in the last 5 daysBook Cheap St. Louis to South Carolina Plane Tickets
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.
Recent round-trip flight deals from St. Louis to South Carolina
Fri, Dec 18 - Mon, Dec 21
6:00 am - 12:59 pmSTL Lambert-St Louis-CHS Charleston
5h 59m1 stop Atlanta Hartsfield-Jackson
6:15 am - 11:52 amCHS Charleston-STL Lambert-St Louis
6h 37m1 stop Atlanta Hartsfield-Jackson
$227Delta
Mon, Nov 23 - Tue, Dec 1
6:59 am - 2:58 pmSTL Lambert-St Louis-GSP Greenville
6h 59m1 stop Washington, D.C. Reagan-National
5:17 pm - 9:59 pmGSP Greenville-STL Lambert-St Louis
5h 42m1 stop Dallas/Fort Worth
$233American Airlines
Tue, Nov 17 - Thu, Nov 19
6:00 am - 11:07 amSTL Lambert-St Louis-GSP Greenville
4h 07m1 stop Atlanta Hartsfield-Jackson
8:11 am - 11:15 amGSP Greenville-STL Lambert-St Louis
4h 04m1 stop Atlanta Hartsfield-Jackson
$233Delta
Thu, Dec 3 - Mon, Dec 7
5:02 am - 11:30 amSTL Lambert-St Louis-CHS Charleston
5h 28m1 stop Chicago O'Hare Intl
4:19 pm - 10:17 pmCHS Charleston-STL Lambert-St Louis
6h 58m1 stop Chicago O'Hare Intl
$237American Airlines
Tue, Nov 17 - Thu, Nov 19
12:40 pm - 7:55 pmSTL Lambert-St Louis-GSP Greenville
6h 15m1 stop Baltimore/Washington
7:05 am - 1:05 pmGSP Greenville-STL Lambert-St Louis
7h 00m2 stops Nashville Intl Houston Hobby
$238Southwest
Tue, Nov 17 - Thu, Nov 19
11:20 am - 8:50 pmSTL Lambert-St Louis-GSP Greenville
8h 30m2 stops Denver Intl Nashville Intl
7:05 am - 1:45 pmGSP Greenville-STL Lambert-St Louis
7h 40m2 stops Nashville Intl Atlanta Hartsfield-Jackson
$243Southwest
Thu, Nov 26 - Thu, Dec 3
8:00 am - 2:28 pmSTL Lambert-St Louis-CHS Charleston
5h 28m1 stop Washington, D.C. Dulles Intl
6:00 am - 12:22 pmCHS Charleston-STL Lambert-St Louis
7h 22m1 stop Chicago O'Hare Intl
$301United Airlines
Thu, Nov 26 - Thu, Dec 3
6:00 am - 1:46 pmSTL Lambert-St Louis-CHS Charleston
6h 46m1 stop Chicago O'Hare Intl
10:23 am - 6:16 pmCHS Charleston-STL Lambert-St Louis
8h 53m2 stops Newark Chicago O'Hare Intl
$306United Airlines
Thu, Nov 19 - Mon, Nov 23
7:24 pm - 11:44 amSTL Lambert-St Louis-MYR Myrtle Beach Intl
15h 20m2 stops Atlanta Hartsfield-Jackson Tampa
2:41 pm - 11:59 pmMYR Myrtle Beach Intl-STL Lambert-St Louis
10h 18m1 stop Orlando
$324Multiple Airlines
Mon, Nov 9 - Fri, Nov 13
6:34 pm - 9:13 amSTL Lambert-St Louis-MYR Myrtle Beach Intl
37h 39m2 stops Atlanta Hartsfield-Jackson Fort Lauderdale
2:41 pm - 11:16 pmMYR Myrtle Beach Intl-STL Lambert-St Louis
9h 35m1 stop Orlando
$324Multiple Airlines
Recent one-way flight deals from St. Louis to South Carolina
Wed, Dec 9
10:06 am - 3:10 pmSTL Lambert-St Louis-CHS Charleston
4h 04m1 stop Atlanta Hartsfield-Jackson
$114Delta
Wed, Dec 9
12:02 pm - 8:38 amSTL Lambert-St Louis-CHS Charleston
19h 36m2 stops Atlanta Hartsfield-Jackson Orlando
$123Multiple Airlines
Wed, Dec 2
12:05 pm - 12:14 pmSTL Lambert-St Louis-MYR Myrtle Beach Intl
23h 09m2 stops Atlanta Hartsfield-Jackson Tampa
$130Multiple Airlines
Thu, Dec 10
5:02 am - 11:30 amSTL Lambert-St Louis-CHS Charleston
5h 28m1 stop Chicago O'Hare Intl
$151American Airlines
Mon, Nov 23
12:54 pm - 7:39 pmSTL Lambert-St Louis-CHS Charleston
5h 45m1 stop Charlotte Douglas
$151American Airlines
Tue, Nov 17
7:13 am - 11:52 amSTL Lambert-St Louis-CHS Charleston
3h 39m1 stop Atlanta Hartsfield-Jackson
$151Delta
Mon, Nov 23
5:00 am - 2:28 pmSTL Lambert-St Louis-CHS Charleston
8h 28m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$156United Airlines
Fri, Dec 18
2:35 pm - 8:40 pmSTL Lambert-St Louis-MYR Myrtle Beach Intl
5h 05m1 stop Nashville Intl
$174Southwest
Fri, Jan 8
11:30 am - 7:10 pmSTL Lambert-St Louis-CHS Charleston
6h 40m2 stops Chicago Midway Nashville Intl
$188Southwest
Tue, Nov 17
5:00 am - 5:11 pmSTL Lambert-St Louis-MYR Myrtle Beach Intl
11h 11m2 stops Chicago O'Hare Intl Newark
$206United Airlines
Recent last minute flight deals from St. Louis to South Carolina
Thu, Nov 5 - Tue, Nov 10
9:08 am - 4:07 pmSTL Lambert-St Louis-CHS Charleston
5h 59m1 stop Charlotte Douglas
10:19 am - 1:18 pmCHS Charleston-STL Lambert-St Louis
3h 59m1 stop Charlotte Douglas
$441American Airlines
Wed, Nov 4 - Mon, Nov 9
7:24 am - 2:39 pmSTL Lambert-St Louis-CHS Charleston
6h 15m1 stop Dallas/Fort Worth
7:13 am - 12:50 pmCHS Charleston-STL Lambert-St Louis
6h 37m1 stop Chicago O'Hare Intl
$441American Airlines
Mon, Nov 2 - Thu, Nov 5
1:20 pm - 8:20 pmSTL Lambert-St Louis-MYR Myrtle Beach Intl
6h 00m1 stop Nashville Intl
7:35 pm - 12:10 amMYR Myrtle Beach Intl-STL Lambert-St Louis
5h 35m1 stop Baltimore/Washington
$499Southwest
Sun, Nov 1 - Thu, Nov 5
2:25 pm - 9:43 pmSTL Lambert-St Louis-MYR Myrtle Beach Intl
6h 18m1 stop Atlanta Hartsfield-Jackson
6:00 am - 10:51 amMYR Myrtle Beach Intl-STL Lambert-St Louis
5h 51m1 stop Atlanta Hartsfield-Jackson
$499Delta
Thu, Nov 5 - Fri, Nov 6
1:20 pm - 8:20 pmSTL Lambert-St Louis-MYR Myrtle Beach Intl
6h 00m1 stop Nashville Intl
1:40 pm - 7:10 pmMYR Myrtle Beach Intl-STL Lambert-St Louis
6h 30m2 stops Baltimore/Washington Milwaukee-Mitchell
$504Southwest
Mon, Nov 2 - Sun, Nov 8
6:00 am - 1:14 pmSTL Lambert-St Louis-CAE Columbia Metropolitan
6h 14m1 stop Atlanta Hartsfield-Jackson
5:40 am - 9:09 amCAE Columbia Metropolitan-STL Lambert-St Louis
4h 29m1 stop Atlanta Hartsfield-Jackson
$619Delta
Wed, Nov 4 - Mon, Nov 9
4:18 pm - 8:38 amSTL Lambert-St Louis-CHS Charleston
15h 20m2 stops Denver Intl Orlando
3:27 pm - 11:16 pmCHS Charleston-STL Lambert-St Louis
8h 49m1 stop Orlando
$632Multiple Airlines
Thu, Nov 5 - Mon, Nov 9
4:26 pm - 8:48 amSTL Lambert-St Louis-CHS Charleston
15h 22m1 stop Orlando
3:27 pm - 3:23 pmCHS Charleston-STL Lambert-St Louis
48h 56m2 stops Orlando Denver Intl
$648Multiple Airlines
Thu, Nov 5 - Fri, Nov 6
9:59 am - 5:11 pmSTL Lambert-St Louis-MYR Myrtle Beach Intl
6h 12m1 stop Newark
11:27 am - 9:40 pmMYR Myrtle Beach Intl-STL Lambert-St Louis
11h 13m2 stops Newark Chicago O'Hare Intl
$664United Airlines
Mon, Nov 2 - Tue, Nov 3
9:59 am - 5:11 pmSTL Lambert-St Louis-MYR Myrtle Beach Intl
6h 12m1 stop Newark
11:27 am - 9:40 pmMYR Myrtle Beach Intl-STL Lambert-St Louis
11h 13m2 stops Newark Chicago O'Hare Intl
$694United Airlines
Recent direct flight deals from St. Louis to South Carolina
Tue, Apr 6 - Thu, Apr 8
2:45 pm - 5:40 pmSTL Lambert-St Louis-CHS Charleston
1h 55mnonstop
6:05 pm - 7:20 pmCHS Charleston-STL Lambert-St Louis
2h 15mnonstop
$474Southwest
Sat, Apr 10 - Wed, Apr 14
3:40 pm - 6:35 pmSTL Lambert-St Louis-CHS Charleston
1h 55mnonstop
4:25 pm - 5:40 pmCHS Charleston-STL Lambert-St Louis
2h 15mnonstop
$474Southwest
Fri, Apr 16 - Sun, Apr 18
2:30 pm - 5:25 pmSTL Lambert-St Louis-CHS Charleston
1h 55mnonstop
5:55 pm - 7:10 pmCHS Charleston-STL Lambert-St Louis
2h 15mnonstop
$515Southwest
Wed, Apr 7 - Sun, Apr 11
2:45 pm - 5:40 pmSTL Lambert-St Louis-CHS Charleston
1h 55mnonstop
5:55 pm - 7:10 pmCHS Charleston-STL Lambert-St Louis
2h 15mnonstop
$525Southwest
Thu, Apr 22 - Mon, Apr 26
2:30 pm - 5:25 pmSTL Lambert-St Louis-CHS Charleston
1h 55mnonstop
6:05 pm - 7:20 pmCHS Charleston-STL Lambert-St Louis
2h 15mnonstop
$531Southwest
Fri, Apr 9 - Sun, Apr 11
2:30 pm - 5:25 pmSTL Lambert-St Louis-CHS Charleston
1h 55mnonstop
5:55 pm - 7:10 pmCHS Charleston-STL Lambert-St Louis
2h 15mnonstop
$536Southwest
Booking Insights
KAYAK's insights & trends for St. Louis to South Carolina flights
Get data-powered insights and trends into flights from St. Louis to South Carolina to help you find the cheapest flights, the best time to fly and much more.
Prices
Airlines
More
How much is a round-trip flight from St. Louis to South Carolina?
This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from St. Louis to South Carolina departing in December.
Flight prices are below average for this route right now.
Flights to South Carolina from St. Louis usually cost between $299 and $565 in December.The lowest price found in the past 5 days was $237 on American Airlines (Dec 3-Dec 7).
What is the cheapest St. Louis to South Carolina flight route?
Data is based on round-trip flight searches on KAYAK over the past month.
The cheapest ticket to South Carolina from St. Louis found in the last 5 days was to Charleston, at $484 round-trip. The most popular route is from St. Louis (STL) to Charleston (CHS), and the cheapest round-trip airline ticket found on this route in the last 5 days was $484.
What is the cheapest time of day to fly to South Carolina?
The average price for all round-trip flights from St. Louis to South Carolina depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.
The cheapest time of day to fly to South Carolina is generally in the morning, when round-trip flights cost $404 on average. Morning departures are around 10% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the afternoon, which is peak travel time and where the average cost of a ticket is $456.
Can I save money by flying with a layover from St. Louis to South Carolina?
The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.
No, with an average price for the route of $424, prices are generally cheapest when you fly direct.
What is the cheapest month to fly from St. Louis to South Carolina?
To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.
The cheapest month for flights from St. Louis to South Carolina is February, when tickets cost $349 (return) on average. On the other hand, the most expensive months are March and October, when the average cost of round-trip tickets is $432 and $429 respectively.
What’s the cheapest day of the week to fly from St. Louis to South Carolina?
The average price of all round-trip flights from St. Louis to South Carolina clicked on KAYAK for each day over the last 12 months.
If you are looking for a flight deal from St. Louis to South Carolina, look for departures on Tuesdays and avoid leaving on a Sunday, as it's usually the priciest day. When flying back from South Carolina, Wednesday is the cheapest day to fly and Sunday is the most expensive.
How far in advance should I book a flight from St. Louis to South Carolina?
To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from St. Louis to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.
To get a below average price on the flight from St. Louis to South Carolina, you should book around 4 weeks before departure, which saves you about 30% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 25 weeks before departure.
Which airlines fly non-stop between St. Louis and South Carolina?
Airline and price data is aggregated from results in KAYAK’s search results from the last 2 weeks for round-trip flights from St. Louis to South Carolina.
There is just one airline that flies from St. Louis to South Carolina direct and that is Southwest. The best round-trip deal found from Southwest for the route is to Charleston (CHS) and costs $245.
Which airlines provide the cheapest flights from St. Louis to South Carolina?
The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 5 days.
In the past 5 days, the cheapest round-trip tickets from St. Louis to South Carolina were found on Southwest ($238) and Delta ($253).
How long does a flight from St. Louis to South Carolina take?
The duration of a flight to South Carolina depends on your arrival airport. The shortest routes to South Carolina from St. Louis are to Charleston, which takes 1h 55m, Myrtle Beach, which takes 3h 20m, and Columbia, which takes 3h 27m.
Which cabin class options are there for flights between St. Louis and South Carolina?
The average price of round-trip flights for each cabin class for the route found by users searching on KAYAK over the last 2 weeks.
There is only one cabin class option available for the route, which is Economy. Perform a search on KAYAK to find the latest prices and availability for all cabin fares, which differ across airlines.
Good to know
Low season | February |
|---|---|
High season | October |
Cheapest flight | $114 |
FAQs - booking South Carolina flights
Top tips for finding cheap flights to South Carolina
Reviews of the top 4 airlines serving from St. Louis to South Carolina
See real verified KAYAK customer reviews for airlines flying from St. Louis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
7.9
SouthwestOverall score based on 4217 reviews
8.6Crew
8.1Boarding
7.4Entertainment
8.0Comfort
7.0Food
Airline reviews
Trash experience on all my flights this week. Delay after delay. The flight I’m waiting for has been delayed 6 times and nearly 3 hours.
2.0 MediocrePhilip, Sep 2026
Trash experience on all my flights this week. Delay after delay. The flight I’m waiting for has been delayed 6 times and nearly 3 hours.
Exceptional. The gate crew responded quickly and got me onto this earlier flight as the final passenger, saving me more than four hours of wait time for my reserved flight.
The flight was delayed due to earlier issues at other airports. The crew was excellent & made it a good trip.
Snacks are always pretzels. Why can't you also offer peanuts ?
Only downside was the legroom and seat width, which is always a problem unless I spend more for a premium seat.
Very good. Sad to learn Southwest is going start to charge for bags
Exceptional crew! Friendly and professional. Pleasant attitude and treated everyone with respect.
The flight was promptly on schedule and Southwest delivered everything they promised. No excuses for any shortfalls just 100% ownership of their responsibilities and business. The boarding and seating policy is a complete shambles. What started out as a great idea when Southwest first hit the market has been turned into a disaster due to the lack of integrity in many of the people who fly Southwest and take advantage of Southwest generosity at the expense of their fellow passengers.
Crew was excellent - Plane was fine. Media was good, could use more kid shows; Not a fan of the brownie brittle -- snack could be slightly better.
Left on time and arrived early. Brand new plane and no parts missing. Comfortable seats. The actual Captain spoke prior to the flight and reassured everyone about safety. Crew was so nice and fun. Perfect flight!
The flight was delayed and passengers were told that they will miss connections as flight may get 40-55 min late.
Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.
From checking to boarding, it was a seamless experience. The service agents were so helpful. The flight crew was so pleasant.
For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.
I am still at the Airport! Delayed Delayed and Delyaed
Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!
My flight was canceled after being rescheduled for four days canceling my trip. Kayak and everyone affiliated with it I.e the airlines, and just fly have been excruciating to deal with. My trip to visit family had to be canceled as there was no way to make it. I am furious at all of you.
They delayed our flight because of bad weather in NY which was completely understandable. Then they cancelled our flight and a later flight that evening. The earliest we could fly was the next morning. We ended up buying last minute tickets on another airline and made it home slightly delayed but safely that evening. Delta kept saying it was weather related but if that was the case how did we make it back on another airline? The weather in NY was cloudy but not bad.
The plane smelled like a sewer. Multiple passengers complained. It’s a safety and quality issue to clean these planes.
We were delayed 2 hours leaving STL. I had 20 mins from when we landed in SLC terminal A to make it to SLC terminal B. I had to actually run! thankfully I made my flight but 3/4 legs were delayed to some capacity.
Requested for warm or hot water because of throat pain, it was denied. The entertainment system was hung, requested the crew to turn it off, instead of turning it off they rebooted the device. It was stuck again, no one bothered to check.
A couple flight attendants in business class had bad attitudes and provided poor service. They did provide drinks or refill drinks. They talked to certain passengers for long periods of time and ignored others.
On boarding crew at the airport called in the boarding numbers too early meaning before the previous line was completed resulting in later numbers getting to board ahead. Also she asked those who boarded from number 3 to have the tags in their carry-on bags and leave it in the jet bridge. Most of the overhead bins were empty though. This is more work for the ground staff in addition to more inconvenience for passengers waiting to get their carry-ons from the jet bridge.
Our flight was great with an unexpected upgrade. However, four days into our travel we are still without a piece of luggage. The bag tracker has not been accurate, the airline is not communicating with me or the luggage delivery service and no one is willing to take responsibility or guarantee any kind of support or reimbursement. Unfortunately, we do not have the option to easily shop to replace items as we are currently on a cruise. I have been very disappointed by United Airlines response.
Awful. No counter attendants. No dinner offered due to delays.
HORRIBLE, my initial flight was cancelled, they made me pay $200 extra dollars and that got cancelled as well! After 6 cancellations I decided to get a refund because I needed to get home to my babies. Out of $1000+ dollars they offered me only $40 in refund! Totally unacceptable! The flight that they cancelled I was able to fly it on another airline. I had to spend $400 on one way tickets just to get home! I’m still getting the runaround.
Flight was delayed only slightly before takeoff due to traffic control. However, the flight arrived early to ORD. Good flight. United has been very reliable for me.
Overall a very poor experience - booked premium economy tickets but due to last minute flight delays , all my itinery went for a toss and had to fly economy class with no access to lounge or any compensation by united airlines to make up for the flight delays . i had expected better experience than that from united.
Onboarding - it would be great to see on the screen what group they were boarding. It was very confusing on who was boarding (even though they called it out) they were not clear and the space to board was strange.
Older plane. Food was really bad, almost not worth the effort. Huge difference with European based airlines.
My luggage was not sent with us. Not sure if this is Envoy Air responsibility but that was a very BAD experience
American delayed the flight for a crew rest period. The delay occurred late in the evening - the earliest i can find is 10:20 pm. With a 6 am flight anyone on the flight would have already have been asleep (unless you are insane, a vampire or on drugs) and at least for me i was already on the way to the airport at 445 am the next morning when i discovered they delayed the flight until 9 am. Given the incoming flight was in the air at 6 pm the evening before this should have been figured out a lot more timely that was there only crew to use. Just frustrating given there is no consideration for customer experience anymore in flying.
Good crew and flight was on time. It’s a small plane with limited overhead luggage space. They said the overhead space was full and I had to check my bag. There was still space when I got on. Waiting for my checked luggage added 30 minutes to my trip. Not the end of the world but also not great.
Trip delayed for 2 hours because of rain. We boarded and have to get down the flight and reboard again.
No enough space plus only allowing one laggage instead of two like other airlines.
Qatar airways ,boarding arrangements at Hamid international airport could been better
Two flight changes before the scheduled flight. On the day of the flight, the flight was delayed, which caused the connecting flight to be missed. Then, I was directed to another airport (CUN) and traveled to Tulum. American gave a $12 voucher for lunch. The least expensive item on the menu at a Mexican restaurant was $9.99. Driving to Tulum was a bad auto crash, and traffic was delayed two-plus hours. The bottom line is that we should have been at the hotel at noon, but it ended up at 11:30 PM.
Miami lounges were overcrowded and we were unable to get in. We only had a short time. But the banks are too tight in all American hubs
Overall boarding and debarking is a joke. I dont even bring luggage anymore on trips because you can never allow them to be place then in the overhead bin or you have to pay or you check them which is even worse having to wait for your luggage on the tarmac.
First time flying internationally with AA and probably my last. Not military friendly at all. Didn't allow free checked bag for military family members (dependents) on orders like other airlines. We were charged $100 for baggage weight overage (5 lbs!)even though we had military orders allowing us extra.. Didn’t allow military members to board early. Inefficient and long wait time to board. Seats are smaller and more uncomfortable than other airlines.. no drink service for over 7 hrs of flight! After initial meal was served, the crew never offered a snack or drinks until the breakfast's was served 1 1/2 hrs before landing. Overall expensive and poor experience for the entire flight.
More options for your flight from St. Louis to South Carolina
Complete your trip to South Carolina with a hotel stay or car rental
Information on your arrival and departure airports
Cabin class types available on flights to South Carolina
Cabin classes available on flights to South Carolina. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights from other airports in St. Louis to South Carolina
Flights from all airports in St. Louis to South Carolina. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights to other popular destinations
The most popular flights on KAYAK according to clicks in the last 2 weeks. Prices are the lowest found on KAYAK over the last 7 days. Price and availability is not guaranteed.
Flights from St. Louis to popular cities in South Carolina
Flights from St. Louis to Augustafrom $503
Flights from St. Louis to Charlestonfrom $301
Flights from St. Louis to Charlottefrom $241
Flights from St. Louis to Columbiafrom $350
Flights from St. Louis to Florencefrom $419
Flights from St. Louis to Greenvillefrom $233
Flights from St. Louis to Savannahfrom $295