MFE - TYS

$399 Find Cheap Flights from McAllen to Knoxville - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$399
Typical prices: $481-$558
American Airlines
Sun 11/11Thu 11/15
MFE - TYS • 1 stop
Nonstop flights
There are currently no direct flights between McAllen and Knoxville. You'll need to take a connecting flight to reach the destination.
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When to travel
Cheapest • 22% price drop
Most popular
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Cheap Flights from McAllen to Knoxville (MFE-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from McAllen to Knoxville

Wed, Nov 11 - Sun, Nov 15
American Airlines Logo
6:32 am - 2:05 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
6h 33m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 10:31 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
6h 01m1 stop Dallas/Fort Worth
$399American Airlines
Wed, Nov 11 - Sun, Nov 15
American Airlines Logo
5:30 am - 3:23 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
8h 53m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
5:30 am - 10:31 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
6h 01m1 stop Dallas/Fort Worth
$404American Airlines
Sat, Jan 30 - Wed, Feb 3
United Airlines Logo
2:12 pm - 9:59 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
6h 47m1 stop Houston George Bush Intcntl
United Airlines Logo
11:53 am - 4:06 pmTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
5h 13m1 stop Houston George Bush Intcntl
$459United Airlines
Sat, Jan 30 - Wed, Feb 3
United Airlines Logo
7:15 am - 4:54 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
8h 39m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
6:30 am - 1:37 pmTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
8h 07m1 stop Houston George Bush Intcntl
$464United Airlines
Sat, Jan 30 - Wed, Feb 3
United Airlines Logo
7:15 am - 4:54 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
8h 39m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
6:55 am - 1:37 pmTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
7h 42m1 stop Houston George Bush Intcntl
$464United Airlines
Wed, Nov 11 - Sun, Nov 15
Delta Logo
5:20 am - 3:15 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
8h 55m2 stops Austin Bergstrom Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 12:19 pmTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
7h 39m2 stops Atlanta Hartsfield-Jackson Austin Bergstrom
$625Delta
Wed, Nov 25 - Mon, Nov 30
American Airlines Logo
4:19 pm - 11:32 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
6h 13m1 stop Dallas/Fort Worth
American Airlines Logo
7:30 pm - 12:18 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
5h 48m1 stop Dallas/Fort Worth
$852American Airlines
Wed, Nov 25 - Mon, Nov 30
American Airlines Logo
4:19 pm - 11:32 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
6h 13m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 11:07 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
6h 37m1 stop Dallas/Fort Worth
$904American Airlines
Wed, Nov 25 - Sun, Nov 29
American Airlines Logo
4:19 pm - 11:32 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
6h 13m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 11:07 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
6h 37m1 stop Dallas/Fort Worth
$1,004American Airlines
Wed, Nov 25 - Mon, Nov 30
American Airlines Logo
11:47 am - 9:41 pmMFE  McAllen Miller Intl-TYS Knoxville McGhee Tyson
8h 54m2 stops Dallas/Fort Worth Charlotte Douglas
American Airlines Logo
5:30 am - 11:07 amTYS  Knoxville McGhee Tyson-MFE McAllen Miller Intl
6h 37m1 stop Dallas/Fort Worth
$1,066American Airlines
Booking Insights

Price, demand and travel trends for McAllen to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from McAllen to Knoxville?

Round-trip flights from McAllen to Knoxville typically range from $481 to $558. The lowest price found in the past 5 days was $399, on American Airlines.

Key details for McAllen to Knoxville flights

Low season

February

Cheapest flight

$399
Beat the crowds with an average 71% drop in travelers.
The most popular month to fly with an average 76% increase in travelers.
Round-trip flight from McAllen to Knoxville

When to book flights from McAllen to Knoxville

Are your dates flexible? Find out the best times to travel from McAllen to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your McAllen to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from McAllen to Knoxville?

    Only Economy Class is available on flights from McAllen to Knoxville.

  • How long is a flight from McAllen to Knoxville?

    A nonstop flight from McAllen to Knoxville takes 00m, covering 1,072 miles.

  • Do I need a passport to fly from McAllen to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a McAllen to Knoxville flight?

    Round-trip flights from McAllen to Knoxville range from $481 to $558, with an average of $533 over the past 12 months. Anything below $481 counts as a good deal.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from McAllen to Knoxville?

    Flights from McAllen to Knoxville usually depart from McAllen Miller Intl (MFE) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from McAllen to Knoxville pass through?

    Most connecting flights from McAllen to Knoxville pass through Dallas/Fort Worth (DFW), which handles 100% of one-stop traffic on this route.

  • Can I save money by using flexible dates for flights from McAllen to Knoxville?

    Yes. Flexible dates can save you up to 46% on flights from McAllen to Knoxville. Saturday is the cheapest departure day at $418 round-trip on average, while Sunday is the most expensive at $763, a difference of $345.

    Cheaper weekend fares like these are typical of routes dominated by weekday business travel.

  • What is the time difference between McAllen and Knoxville?

    Knoxville is 1 hour ahead of McAllen (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking McAllen to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Saturday departure and avoid flying on Sunday. On this route, Saturday flights average $418, about $345 less than Sunday fares (45% savings) based on the last 12 months.
  • If you can choose when to travel, plan your McAllen to Knoxville trip for October. Fares historically average $418 round-trip in that month - typically $345 less than the most expensive month, which is January (based on the last 12 months).

More options for your flight from McAllen to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental