MFE - TYS

$386 Find Cheap Flights from McAllen to Knoxville

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from McAllen to Knoxville departing on 5/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from McAllen to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from McAllen to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$330
United Airlines
Sat 5/30Wed 6/3
MFE - TYS • 2 stops
Top airlines
American Airlines
Cheapest • from $386 (round-trip)
American Airlines
Best reviews • 7.1 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between McAllen and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Houston (IAH)
Cheapest • Avg $290 (round-trip)
Houston (IAH)
Shortest trip • 4h 43m (one-way)
Insights
Insights
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from McAllen to Knoxville (MFE-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from McAllen to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from McAllen to Knoxville

Sat, May 30 - Wed, Jun 3
United Airlines Logo
5:00 am - 4:51 pm
MFE
-
TYS
10h 51m
2 stops
United Airlines Logo
3:25 pm - 9:51 pm
TYS
-
MFE
7h 26m
1 stop
$330United Airlines
Sat, May 30 - Wed, Jun 3
United Airlines Logo
7:00 am - 4:51 pm
MFE
-
TYS
8h 51m
2 stops
United Airlines Logo
6:30 am - 3:59 pm
TYS
-
MFE
10h 29m
2 stops
$338United Airlines
Sat, May 30 - Wed, Jun 3
United Airlines Logo
5:00 am - 4:51 pm
MFE
-
TYS
10h 51m
2 stops
United Airlines Logo
1:54 pm - 9:51 pm
TYS
-
MFE
8h 57m
2 stops
$374United Airlines
Sat, Mar 28 - Wed, Apr 1
American Airlines Logo
5:28 am - 11:30 am
MFE
-
TYS
5h 02m
1 stop
American Airlines Logo
5:40 am - 10:15 am
TYS
-
MFE
5h 35m
1 stop
$386American Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
2:05 pm - 9:30 pm
MFE
-
TYS
6h 25m
1 stop
United Airlines Logo
12:05 pm - 3:59 pm
TYS
-
MFE
4h 54m
1 stop
$391United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
7:00 am - 8:48 pm
MFE
-
TYS
12h 48m
2 stops
United Airlines Logo
7:15 am - 11:23 am
TYS
-
MFE
5h 08m
1 stop
$396United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
7:00 am - 4:59 pm
MFE
-
TYS
8h 59m
2 stops
United Airlines Logo
6:30 am - 3:59 pm
TYS
-
MFE
10h 29m
2 stops
$401United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
2:05 pm - 9:30 pm
MFE
-
TYS
6h 25m
1 stop
United Airlines Logo
7:15 am - 1:21 pm
TYS
-
MFE
7h 06m
1 stop
$411United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
9:38 am - 8:48 pm
MFE
-
TYS
10h 10m
2 stops
United Airlines Logo
7:15 am - 11:23 am
TYS
-
MFE
5h 08m
1 stop
$416United Airlines
Sat, Aug 22 - Wed, Aug 26
United Airlines Logo
5:00 am - 4:59 pm
MFE
-
TYS
10h 59m
2 stops
United Airlines Logo
6:30 am - 3:59 pm
TYS
-
MFE
10h 29m
2 stops
$421United Airlines
Booking Insights

KAYAK's insights & trends for McAllen to Knoxville flights

Get data-powered insights and trends into flights from McAllen to Knoxville to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from McAllen to Knoxville?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from McAllen to Knoxville were found on American Airlines ($386) and United Airlines ($391).

Find deals

Good to know

Low seasonApril
Cheapest flight$330
Best time to beat the crowds with an average 50% drop in price.
Most popular time to fly and prices are also 32% lower on average.
Flight from McAllen to Knoxville

When to book flights from McAllen to Knoxville

Are your dates flexible? Find out the best times to travel from McAllen to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from McAllen to Knoxville

  • What is the cheapest flight from McAllen to Knoxville?

    In the last 3 days, the lowest price for a flight from McAllen to Knoxville was $386 for a round-trip ticket.

  • Do I need a passport to fly between McAllen and Knoxville?

    No, a passport isn't needed to fly from McAllen to Knoxville. However, local authorities might ask for an official ID.

  • Which aircraft models fly most regularly from McAllen to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from McAllen to Knoxville?

    oneworld is the only airline alliance operating flights between McAllen and Knoxville.

  • How does KAYAK find such low prices on flights from McAllen to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from McAllen to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from McAllen to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from McAllen is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from McAllen to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to McAllen with another airline. Booking your flights between McAllen and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from McAllen to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from McAllen up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from McAllen to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from McAllen to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from McAllen to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11468 reviews
6.4Food
7.9Crew
6.9Entertainment
7.5Boarding
7.2Comfort
Airline reviews

Easy boarding. Rows are smaller but that may be an older and bigger me now :)

10.0 ExcellentEric, Mar 2026
DFW - DCA
Read more American Airlines reviews

Easy boarding. Rows are smaller but that may be an older and bigger me now :)

Check in was rough because the check in crew did not know how to manage my international visa documents. Required a long process and 4 people to finally be able to proceed to security. They told us incorrect information several times before acknowledging we did indeed have everything we needed from the start.

Poor communication ahead of time about flight delays and old planes/other equipment.

Mechanical issue delayed us 2hrs and then once we landed sat on tarmac for 30mins because someone left a vehicle in front of the gaye

The crew was excellent and overall the flight was good. No complaints.

Like all of the flights I took to get down to Dallas. They were delayed

Forced to check bags. Crew uninterested in collecting trash. Unclean seats.

Flight pulled out on time but sat on runway for 30 mins. It was extremely cold in the aircraft despite wearing a winter coat. Surprisingly they had a vegetarian meal but could have some better snack choices for a 8 hour flight.

We had a male flight attendant who was super attentive and wonderful! Very professional. I have both gluten and dairy intolerance, and was only able to get a gluten free part, and not the dairy free part of the meal. Easy to order ahead of time and I appreciate being able to do that.

It was a train wreck but on an airplane. First off, flight was delayed then we board only to hear two announcements, First weather delays in Orlando and second backup battery warning on emergency lights. After sitting on the plane for almost 2 hours they have us deplane due to the maintenance issue. We were told they were getting another plane. In the mean time, I notice another American- Orlando flight and ask the gate agent if I can switch. He says he cant help me and I'd have to walk to A13 from A37. Really!? I get down there and get a seat only to get an announcement my original flight was RE-boarding. The Then inflight there's no communication and I notice on flightaware were circling over the Gulf of America. I call the flight attendant and of course she has no clue and apparently 5m later the pilot finally tells us about another delay. Why does American always have these service and delay issues? They are my LAST choice in flights now!

Everything you need to know for your flight from McAllen to Knoxville

Information on your arrival and departure airports

McAllen (MFE)
Knoxville (TYS)