$166 Find Cheap Flights from Medford to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Medford to South Carolina departing on 9/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medford to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medford to South Carolina, as well as popular online travel agencies
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Cheap Flights from Medford to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston2 stops$361
Greenville
Greenville2 stops$414
Columbia
Columbia2 stops$379
Charlotte
Charlotte1 stop$339
Charleston
Charleston2 stops$361
Greenville
Greenville2 stops$414
Columbia
Columbia2 stops$379
Charlotte
Charlotte1 stop$339

Book Cheap Medford to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Medford to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Medford to South Carolina

Sun, Sep 7 - Sun, Sep 14
United Airlines Logo
5:00 am - 3:11 pmMFR-CLT
7h 11m1 stop
United Airlines Logo
8:30 am - 1:08 pmCLT-MFR
7h 38m1 stop
$339United Airlines
Find Deal
Tue, Sep 9 - Sat, Sep 13
United Airlines Logo
6:35 pm - 10:23 amMFR-CAE
12h 48m2 stops
United Airlines Logo
11:04 am - 9:04 pmCAE-MFR
13h 00m2 stops
$379United Airlines
Find Deal
Tue, Nov 11 - Wed, Nov 26
Delta Logo
5:30 am - 4:21 pmMFR-CLT
7h 51m1 stop
Delta Logo
5:29 pm - 11:56 pmCLT-MFR
9h 27m1 stop
$384Delta
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Tue, Nov 11 - Wed, Nov 26
Delta Logo
6:00 am - 10:42 pmMFR-CLT
13h 42m2 stops
Delta Logo
5:29 pm - 11:56 pmCLT-MFR
9h 27m1 stop
$389Delta
Find Deal
Tue, Sep 23 - Sat, Sep 27
Delta Logo
5:00 pm - 10:17 amMFR-CAE
14h 17m2 stops
Delta Logo
5:40 am - 3:34 pmCAE-MFR
12h 54m2 stops
$402Delta
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Sun, Sep 7 - Sun, Sep 14
American Airlines Logo
5:30 am - 3:45 pmMFR-CLT
7h 15m1 stop
American Airlines Logo
6:27 pm - 11:00 pmCLT-MFR
7h 33m1 stop
$414American Airlines
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Sat, Sep 6 - Wed, Sep 10
United Airlines Logo
6:35 pm - 11:56 amMFR-GSP
14h 21m2 stops
United Airlines Logo
4:30 pm - 9:04 pmGSP-MFR
7h 34m1 stop
$414United Airlines
Find Deal
Sat, Sep 6 - Wed, Sep 10
United Airlines Logo
5:00 am - 3:00 pmMFR-GSP
7h 00m1 stop
United Airlines Logo
4:30 pm - 9:04 pmGSP-MFR
7h 34m1 stop
$454United Airlines
Find Deal
Sat, Sep 6 - Wed, Sep 10
United Airlines Logo
6:35 pm - 8:51 amMFR-GSP
11h 16m2 stops
United Airlines Logo
4:30 pm - 9:04 pmGSP-MFR
7h 34m1 stop
$519United Airlines
Find Deal
Sat, Sep 6 - Wed, Sep 10
American Airlines Logo
5:30 am - 10:30 pmMFR-GSP
14h 00m2 stops
American Airlines Logo
10:25 am - 7:16 pmGSP-MFR
11h 51m2 stops
$524American Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Medford to South Carolina flights

Get data-powered insights and trends into flights from Medford to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Medford to South Carolina?

The average price of all round-trip flights from Medford to South Carolina clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from Medford to South Carolina, look for departures on Saturdays and avoid leaving on a Friday, as it's usually the priciest day. When flying back from South Carolina, Wednesday is the cheapest day to fly and Thursday is the most expensive.

Good to know

Low seasonApril
Cheapest flight$166
Best time to beat the crowds but there is an average 1% increase in price.
Most popular time to fly with an average 72% increase in price.
Flight from Medford to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Medford to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Medford to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Medford to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Medford to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Medford to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Medford to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Medford to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Medford to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally in the morning, when round-trip flights cost $617 on average. The most expensive time of day to fly to South Carolina is generally in the morning, which is peak travel time and where the average cost of a ticket is $617.

Reviews of the top 3 airlines serving from Medford to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Medford to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Medford to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
Alaska AirlinesOverall score based on 10000 reviews
7.8Comfort
7.0Entertainment
8.5Crew
7.1Food
8.1Boarding
Airline reviews

It was fine—the seats are not very comfortable and the aisles are very narrow. Nothing different from other airlines

8.0 ExcellentAnonymous, Aug 2025PDX - SMF
Read more Alaska Airlines reviews

It was fine—the seats are not very comfortable and the aisles are very narrow. Nothing different from other airlines

I booked a round trip. I ordered a lunch going and a lunch for the return but got both lunches going. Could have been my error. Both lunches were good.

Well the flight being delayed multiple time really was frustrating. But the crew and flight was good.

generally good. No snacks or drinks on the flight 3379 from Portland to San Jose, CA. Sad.

Everything except for the lack of a choice of the snack provided was great.

All went smoothly. Only one delay departing Seattle of around 30 minutes.

I like the friendliness of the staff. The food choices were OK. I wish there was more options. The entertainment through the movie portal was alright.

First time flying with Alaska, and it went great. Thank you for a great experience flying to PDX.

There was a very drunk man behind me who kept talking loudly to no one in particular. He was slurring his words and at times he didn’t know where we were going or whether or not we landed. He was also loudly using a lot of profanity. The attendants didn’t seem to notice or care and in fact continued to serve him alcohol. He was allowed to purchase 4 little bottles.

We did not realize there wasn't any food apart from a small packet of pretzels - I dropped one and nearly cried.

This route with Delta always has delays or is cancelled. Aircrafts seem smaller and older. I fly Delta quite a bit - haven’t had issues with the international flights. But this route has always been the troublesome one

Three seats in first class were broken and while they were able to still acommodate us it was looking very touch and go and they had others they could not acommodate

Mechanic delay in addition to a 2 hour change in takeoff time was frustrating.

Delayed due to thunderstorms and no in-flight service due to rough weather — both of which are out of Delta’s control. Flight was good overall.

The flight attendants in SLC were rude. I arrived 40 minutes early to gate. Ticket said I needed check in for seat assignments and tried check in and attendants said they weren’t doing it. And proceeded to never call me to give me a ticket so when time to board I received the very last seat. Please relay to employees to do their job better..,

On this flight I felt the food offering was not as complete as on previous flights. The tomato salad was a bit off and there was nothing additional such a bread or butter. The breakfast was only one option, so you either ate what they had or ate nothing. The crew was efficient, but most seemed frustrated throughout the flight. The flight arrived early and was obstacle-free, so I’m overall quite happy, but the shine in the rest of the experience just wasn’t there.

The seats got pretty uncomfortable pretty fast. The armrests are bigger than on other planes, so I had less room in the actual seat. My butt hurt by the end of the flight. :/ comfort was the primary issue. The crew were fantastic!

I believe that a four-hour trip should have a meal. Delta had none.

Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!

I was uncomfortably cold on the plane. Other than that it was uneventful and therefore as enjoyable as a plane ride can be.

Armrest controller on my seat 35D and nextbooennseat 35E did not work right. Hard to press buttons to recognize and 35D had constantnpressure either upmost down somit was nearly impossible to make selections. .

I flew with my dog and had already purchased my dog’s ticket. Even that morning I had called costumer service to insure that my husband and I had seats together since the website was giving me an error when choosing our seats and the representative mentioned our dog. I showed up early to the airport and when I got to the gate and we started boarding I was help back and told that I was supposed to have a yellow tag and that I should have checked in at the counter for them to give me that tag. I was not aware of this, the representative on the phone did not say anything. Nor did I see it anywhere in the checking process online, so if you travel with a pet and are not checking in luggage, just know that you still have to go to the check in counter when arriving at the airport unless you want to be the last one to board and not have room for your carry on in the overhead bins. Other than that, I had a great experience.

Once we got in the air the pilot made up some of the time of the delay. So that was really nice.

I understand stuff happens, but plane failures are likely due to lack of maintenance. Additionally, air conditioning wasn't working, no snack/drink service, no WiFi. Fortunately, the crew was communicative and light-hearted. United grabbed another plane and we were able to get to our destination.

There was no food available for this red eye... one little waffle cookie for a 6+ hour flight... thank God I was able to sleep some

It is clear that someone knew, and competent, is in charge of food at United Airlines at least for the international flights. I was flying in coach, but the choices of the dinner were excellent. Tasty, and appropriate size. I had the beef, which was a little bit like a shepherds pie, and it was good. Nothing comparable has been served on a United flight in years. It will not be confused with three star food, but it is very good for airline food. Even better was the breakfast choice between a cinnamon roll and a breakfast sandwich. I chose the breakfast sandwich which was absolutely delicious and which I would happily order again at my local Starbucks or Panera. It is clear that someone knew indifferent is in charge of the food and it’s about time.

The flight was comfortable with the exit row and great service

Had to cancel first flight because Airporter Bus took over 3 hrs to get to airport which resulted in an extra $378 dollar fare . Is there anyway I can be reimbursed for initial fare since it was not my fault? Sent from my iPhone EJ Ledet

Plane was crowded and even when we hit altitude, the plane was hot, not enough air flow.

Flight attendant in first class gave poor service (like he didn't want to be there) and food was awful. We sat waiting for gate upon arrival over 45 mins.

Everything you need to know for your flight from Medford to South Carolina

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