MEX - SCL

$260 Find Cheap Flights from Mexico City to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 3/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Mexico City to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Mexico City to Santiago, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$465
Overall average: $628
Multiple Airlines
Thu 3/12Thu 3/19
MEX - SCL • Non-stop
Cheapest non-stop
$500
Typical prices: $546-$757
LATAM Airlines
Mon 3/9Mon 3/16
MEX - SCL • Non-stop
Our travelers' advice
AI-powered summary based on content written by travel experts. AI can make mistakes.
Aeromexico's AM Plus seats offer 38” pitch in economy.
LATAM's LATAM+ seats provide up to 35” pitch for comfort.
Expert advice
Expert advice
Expert advice
Expert advice
Top airlines
LATAM Airlines
Cheapest • from $500 (round-trip)
LATAM Airlines
Best reviews • 7.5 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to book
6 weeks
in advance
Our data shows that travelers who book at least 6 weeks in advance save around 18% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
May
Cheapest • 13% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Expert advice
Flight Deals

Cheap Flights from Mexico City to Santiago (MEX-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Mexico City to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Mexico City to Santiago

Thu, Mar 12 - Thu, Mar 19
Multiple Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
Multiple Airlines Logo
9:05 pm - 11:10 am
SCL
-
MEX
17h 05m
1 stop
$465Multiple Airlines
Fri, Jun 5 - Sat, Jun 13
Multiple Airlines Logo
10:00 pm - 1:30 pm
MEX
-
SCL
13h 30m
1 stop
Multiple Airlines Logo
8:20 pm - 11:10 am
SCL
-
MEX
16h 50m
1 stop
$481Multiple Airlines
Sun, Mar 15 - Wed, Mar 18
LATAM Airlines Logo
5:25 pm - 12:45 pm
MEX
-
SCL
16h 20m
1 stop
LATAM Airlines Logo
9:40 pm - 2:50 pm
SCL
-
MEX
20h 10m
1 stop
$500LATAM Airlines
Tue, Mar 17 - Tue, Mar 31
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
9:15 am - 2:55 pm
SCL
-
MEX
8h 40mnonstop
$513LATAM Airlines
Tue, Jun 9 - Thu, Jun 18
Multiple Airlines Logo
6:45 am - 2:35 am
MEX
-
SCL
17h 50m
2 stops
Multiple Airlines Logo
8:20 pm - 11:10 am
SCL
-
MEX
16h 50m
1 stop
$520Multiple Airlines
Tue, Jun 9 - Fri, Jun 19
Multiple Airlines Logo
6:45 am - 2:35 am
MEX
-
SCL
17h 50m
2 stops
Multiple Airlines Logo
8:20 pm - 11:10 am
SCL
-
MEX
16h 50m
1 stop
$526Multiple Airlines
Thu, Mar 12 - Thu, Mar 19
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
9:00 am - 3:15 pm
SCL
-
MEX
9h 15mnonstop
$530LATAM Airlines
Thu, Mar 12 - Thu, Mar 19
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
4:35 am - 8:20 pm
SCL
-
MEX
18h 45m
2 stops
$535LATAM Airlines
Sat, Jun 13 - Fri, Jun 19
Multiple Airlines Logo
10:00 pm - 1:30 pm
MEX
-
SCL
13h 30m
1 stop
Multiple Airlines Logo
8:20 pm - 11:10 am
SCL
-
MEX
16h 50m
1 stop
$536Multiple Airlines
Thu, Mar 12 - Thu, Mar 19
LATAM Airlines Logo
7:50 pm - 7:30 am
MEX
-
SCL
8h 40mnonstop
LATAM Airlines Logo
9:00 am - 3:15 pm
SCL
-
MEX
9h 15mnonstop
$540LATAM Airlines
Booking Insights

KAYAK's insights & trends for Mexico City to Santiago flights

Get data-powered insights and trends into flights from Mexico City to Santiago to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Mexico City to Santiago?

The average price of all round-trip flights from Mexico City to Santiago clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Santiago on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Mexico City to Santiago. For your return ticket, we recommend flying on a Monday and avoiding Sundays for the best deals.

What is the cheapest month to fly from Mexico City to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Mexico City to Santiago is May, where tickets cost $531 (return) on average. On the other hand, the most expensive months are December and February, where the average cost of round-trip tickets is $681 and $680 respectively.

Can I save money by flying with a layover from Mexico City to Santiago?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $724 on average.

How far in advance should I book a flight from Mexico City to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Mexico City to Santiago, you should book around 6 weeks before departure, which saves you about 18% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 13 weeks before departure.

Expert advice

Expert advice for your flight from Mexico City to Santiago

 
AI-powered summary based on content written by travel experts. AI can make mistakes.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Our travel experts
Marisa Garcia

Marisa Garcia

Expert on LATAM Airlines and Aeromexico

Marisa knows planes inside and out, spending 16 years working on aircraft in hangars at airports around the world. She is an aviation industry expert, specialized in airline interiors and regulations. Ten years ago, she pivoted to journalism. She shares her insights in leading aviation, travel, and business publications and on her site FlightChic.

Good to know

Low seasonJune
Cheapest flight$260
Best time to beat the crowds but there is an average 2% increase in price.
Most popular time to fly with an average 11% increase in price.
Flight from Mexico City to Santiago

When to book flights from Mexico City to Santiago

Are your dates flexible? Find out the best times to travel from Mexico City to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Mexico City to Santiago

  • What is the cheapest flight from Mexico City to Santiago?

    In the last 3 days, the lowest price for a flight from Mexico City to Santiago was $260 for a one-way ticket and $465 for a round-trip.

  • Do I need a passport to fly between Mexico City and Santiago?

    Yes

  • Which airports will I be using when flying from Mexico City to Santiago?

    Mexico City airport is called Mexico City Benito Juarez and the only airport in Santiago is Santiago Arturo Merino Benitez.

  • Which aircraft models fly most regularly from Mexico City to Santiago?

    The Airbus A330 is the aircraft model that flies most regularly on the Mexico City to Santiago flight route.

  • Which airline alliances offer flights from Mexico City to Santiago?

    SkyTeam, and Star Alliance are the airline alliances operating flights between Mexico City and Santiago, with SkyTeam being the most commonly used for this route.

  • On which days can I fly direct from Mexico City to Santiago?

    There are nonstop flights from Mexico City to Santiago on a daily basis.

  • Which is the best airline for flights from Mexico City to Santiago, LATAM Airlines or Copa Airlines?

    The two airlines most popular with KAYAK users for flights from Mexico City to Santiago are LATAM Airlines and Copa Airlines. With an average price for the route of $663 and an overall rating of 7.5, LATAM Airlines is the most popular choice. Copa Airlines is also a great choice for the route, with an average price of $563 and an overall rating of 7.5.

  • How does KAYAK find such low prices on flights from Mexico City to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Mexico City to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Mexico City to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Mexico City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Mexico City to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Mexico City with another airline. Booking your flights between Mexico City and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Mexico City to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Mexico City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Mexico City to Santiago

  • Looking for a cheap flight? 25% of our users found flights on this route for $347 or less one-way and $734 or less round-trip.

Prefer to fly direct from Mexico City to Santiago?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Find which airlines fly direct from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport, which days they fly and book direct flights.

Direct departures

Mexico City Benito Juarez to Santiago Arturo Merino Benitez

Monday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Tuesday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Wednesday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Thursday

LATAM Airlines

LATAM Airlines

Friday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Saturday

LATAM Airlines

LATAM Airlines

Sunday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

See more direct flights

Direct returns

Santiago Arturo Merino Benitez to Mexico City Benito Juarez

Monday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Tuesday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Wednesday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Thursday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Friday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Saturday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Sunday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

See more direct flights

Reviews of the top 4 airlines serving from Mexico City to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Mexico City to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Mexico City to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1921 reviews
7.3Comfort
6.7Food
7.5Boarding
7.0Entertainment
8.0Crew
Airline reviews

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

10.0 ExcellentSarah, Jan 2026
ANF - SCL
Read more LATAM Airlines reviews

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Poor, the airline was not able to help me move flights.

The plane broke down at the Lima stopover and they offered to put me on a flight the be t day but I had to be back in LA that morning and so I had to buy another ticket from Avianca and United for $2k I asked LATAM for compensation and received none. Very bad experience

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

Copa staff at PTY and one particular crew member were unhelpful & rude.

Seats were awful. Media should have been included for such a long flight.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

I always enjoy flying Copa. There are very few airlines where I can enjoy a comfortable sleep in-flight. The snacks weren't the best, but they sufficed. The in-flight entertainment was fantastic, and I crossed another movie off my watch list.

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

They were super friendly bumped me up to exit row free of charge, All flight legs were on time

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

horrible service, food was an embarrassment, no charging for cellphones, stay away

Great experience with a crew always thinking in the passenger

It was OK. The flight is pretty long for the airlines to only offer a simple sandwich on business class. The entertainment is similar to that on other Skyteam members. Ultimately the airline lost my bag and didn’t deliver it to me until the next day after a lengthy lost baggage report.

Good, the flight from Miami to Mexico City was better than Mexico City to Miami

Flight was on time, good service, but there was no free WiFi, even for first class passengers

It was good in general. The Crew during the flight were very nice at all times.

The ground staff were not as friendly and nice to the passengers as the air crew. Flight attendants, cockpit crew were great and very nice to everyone on board.

My flight was delayed, then I got transferred to a new flight that was also delayed- which wasn’t Aeromexico’s fault, it was because of weather conditions. Most of the crew was very nice and patient, except for one or two flight attendants who were rude. The entertainment wasn’t on, so all the screens were off.

My wife's entertainment system did not work. Payed for flight upgrade but did not receive advertised "free WiFi".

Annoying that we had to go to departures and get boarding passes. Should allow us to be booked all the way through, this is the only airline i have this problem with in MEX. Late boarding and take off

the guy in front of me put his seat back immediately...and then left it back including thru landing and taxiing to the runway. attendants did not check/ask him to put it up for landing.

Lousy No wheelchair. As normal at Atlanta Cheap airline Cheap aero plane. - Neither entertainment nor food on a 5 hour saga

Horrible experience with Avianca, they delayed their flight and when we arrived to NYC, AVIANCA took 1 hr y 30 mins to park the airplane and all passenger get off the plane, it made me lost all my trains to get back home and I came back to my place at 3 am instead of 12 am. On the top of that their plane seat are so uncomfortable and is not enough space and killed my legs and knees, Avianca used to be good when it was a Colombian company, now after Brasilian company bought them, their service quality is bad and their flights are delayed and oversold.

It was delayed and I lost my connection flight to Cali and I missed my Mom's funeral

The flight attendant smashed her beverage cart into my knee, causing significant amount of pain. The seats were extremely uncomfortable. No food or drink is offered unless you want to pay the ridiculous prices for it. The schedule of flying in the overnight hours is also very uncomfortable.

We waited for one hour to deboard the plane after landing. That could be better

I like the crew they're very friendly. I don't like. on five hour flight they not offered snacks. Any drink. Not even coffee

Not even water is offered on the flight. You cannot lean back on the seats and the seats are so narrow you can’t avoid rubbing elbows with the person next to you.

I couldnt recline the seat. Other than that crew was very attentive and helpful. Thsnk you

This low cost airline looks and fells more like a local bus. In a 6 hour flight not being able to recline a seat is torture. The only thing available with no charge is a glass of water provided by, mostly, rude staff. Our luggage didn’t arrive

Horrible experience. Flight cancelled. Arrived at destination 12 hs later. No one gave us an answer or any information. Very very poor service. We won’t ever travel again with Avianca

Did not fly with Pakistan International Airlines. Have never flown with Pakistan International Airlines.

Everything you need to know for your flight from Mexico City to Santiago

Information on your arrival and departure airports