MEX - SCL

$308 Find Cheap Flights from Mexico City to Santiago - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$641
Typical prices: $555-$805
Multiple Airlines
Tue 9/29Fri 10/23
MEX - SCL • 2 stops
Cheapest non-stop
$707
Typical prices: $647-$833
LATAM Airlines
Wed 8/19Wed 9/23
MEX - SCL • Non-stop
Top airlines
Cheapest • from $703 (round-trip)
Best reviews • 7.6 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
You can fly direct with LATAM Airlines. Average duration is 8h 50m
Direct flights
Direct flights
+1
+1
Direct flights
Direct flights
+1
Avoid delays
Most punctual • 92% on-time
Best time • Fewest delays
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $492 (round-trip)
Shortest trip • 10h 45m (one-way)
Insights
Insights
Insights
Insights
When to book
in advance
Our data shows that travelers who book at least 6 weeks in advance save around 17% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
Cheapest • 14% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
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We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Expert advice
Flight Deals

Cheap Flights from Mexico City to Santiago (MEX-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Mexico City to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Mexico City to Santiago

Tue, Sep 29 - Fri, Oct 23
Multiple Airlines Logo
7:00 am - 3:35 am
MEX
-
SCL
17h 35m
2 stops
Multiple Airlines Logo
8:33 pm - 11:10 am
SCL
-
MEX
17h 37m
1 stop
$641Multiple Airlines
Thu, Oct 1 - Thu, Oct 22
Multiple Airlines Logo
6:45 am - 3:35 am
MEX
-
SCL
17h 50m
2 stops
Multiple Airlines Logo
8:33 pm - 11:10 am
SCL
-
MEX
17h 37m
1 stop
$648Multiple Airlines
Tue, Oct 20 - Wed, Oct 28
Multiple Airlines Logo
10:00 pm - 5:16 am
MEX
-
SCL
28h 16m
1 stop
Multiple Airlines Logo
8:33 pm - 11:10 am
SCL
-
MEX
17h 37m
1 stop
$653Multiple Airlines
Sun, Sep 13 - Fri, Sep 18
Multiple Airlines Logo
6:45 am - 4:55 am
MEX
-
SCL
19h 10m
2 stops
Multiple Airlines Logo
6:00 am - 12:10 pm
SCL
-
MEX
33h 10m
2 stops
$655Multiple Airlines
Tue, Sep 29 - Thu, Oct 22
Multiple Airlines Logo
10:00 pm - 2:35 pm
MEX
-
SCL
13h 35m
1 stop
Multiple Airlines Logo
8:33 pm - 11:10 am
SCL
-
MEX
17h 37m
1 stop
$656Multiple Airlines
Tue, Sep 29 - Sat, Oct 17
Multiple Airlines Logo
7:00 am - 3:35 am
MEX
-
SCL
17h 35m
2 stops
Multiple Airlines Logo
8:33 pm - 11:10 am
SCL
-
MEX
17h 37m
1 stop
$661Multiple Airlines
Sun, Sep 13 - Wed, Nov 4
Multiple Airlines Logo
10:00 pm - 10:05 pm
MEX
-
SCL
21h 05m
1 stop
Multiple Airlines Logo
7:25 am - 6:10 pm
SCL
-
MEX
13h 45m
1 stop
$662Multiple Airlines
Thu, Oct 1 - Fri, Oct 23
Multiple Airlines Logo
6:45 am - 3:35 am
MEX
-
SCL
17h 50m
2 stops
Multiple Airlines Logo
8:33 pm - 11:10 am
SCL
-
MEX
17h 37m
1 stop
$668Multiple Airlines
Wed, Sep 30 - Thu, Oct 22
Multiple Airlines Logo
10:00 pm - 12:41 pm
MEX
-
SCL
11h 41m
1 stop
Multiple Airlines Logo
8:33 pm - 11:10 am
SCL
-
MEX
17h 37m
1 stop
$674Multiple Airlines
Tue, Sep 29 - Fri, Oct 23
Multiple Airlines Logo
10:00 pm - 2:35 pm
MEX
-
SCL
13h 35m
1 stop
Multiple Airlines Logo
8:33 pm - 11:10 am
SCL
-
MEX
17h 37m
1 stop
$675Multiple Airlines
Booking Insights

KAYAK's insights & trends for Mexico City to Santiago flights

Get data-powered insights and trends into flights from Mexico City to Santiago to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Mexico City to Santiago?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Mexico City to Santiago departing in September.

Flight prices are typical for this route right now.

Flights to Santiago from Mexico City usually cost between $636 and $821 in September.
The lowest price found in the past 5 days was $641 on Multiple Airlines (Sep 29-Oct 23).

What’s the cheapest day of the week to fly from Mexico City to Santiago?

The average price of all round-trip flights from Mexico City to Santiago clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Santiago on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Mexico City to Santiago. For your return ticket, we recommend flying on a Monday and avoiding Fridays for the best deals.

What is the cheapest month to fly from Mexico City to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Mexico City to Santiago is January, where tickets cost $585 (return) on average. On the other hand, the most expensive months are July and June, where the average cost of round-trip tickets is $772 and $770 respectively.

Can I save money by flying with a layover from Mexico City to Santiago?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $769 on average.

How far in advance should I book a flight from Mexico City to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Mexico City to Santiago, you should book around 6 weeks before departure, which saves you about 17% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 9 weeks before departure.

Expert advice

Expert advice for your flight from Mexico City to Santiago

 
AI-powered summary based on content written by travel experts. AI can make mistakes.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Our travel experts
Marisa Garcia

Marisa Garcia

Expert on LATAM Airlines and Aeromexico

Marisa knows planes inside and out, spending 16 years working on aircraft in hangars at airports around the world. She is an aviation industry expert, specialized in airline interiors and regulations. Ten years ago, she pivoted to journalism. She shares her insights in leading aviation, travel, and business publications and on her site FlightChic.

Good to know

Low season

June

Cheapest flight

$308
Best time to beat the crowds but there is an average 12% increase in price.
Flight from Mexico City to Santiago

When to book flights from Mexico City to Santiago

Are your dates flexible? Find out the best times to travel from Mexico City to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Mexico City to Santiago

  • What is the cheapest flight from Mexico City to Santiago?

    In the last 5 days, the lowest price for a flight from Mexico City to Santiago was $308 for a one-way ticket and $641 for a round-trip.

  • Do I need a passport to fly between Mexico City and Santiago?

    Yes

  • Which airports will I be using when flying from Mexico City to Santiago?

    Mexico City airport is called Mexico City Benito Juarez and the only airport in Santiago is Santiago Arturo Merino Benitez.

  • Which aircraft models fly most regularly from Mexico City to Santiago?

    The Airbus A330 is the aircraft model that flies most regularly on the Mexico City to Santiago flight route.

  • Which airline alliances offer flights from Mexico City to Santiago?

    Star Alliance, and SkyTeam are the airline alliances operating flights between Mexico City and Santiago, with Star Alliance being the most commonly used for this route.

  • On which days can I fly direct from Mexico City to Santiago?

    There are nonstop flights from Mexico City to Santiago on a daily basis.

  • Which is the best airline for flights from Mexico City to Santiago, Copa Airlines or LATAM Airlines?

    The two airlines most popular with KAYAK users for flights from Mexico City to Santiago are Copa Airlines and LATAM Airlines. With an average price for the route of $646 and an overall rating of 7.6, Copa Airlines is the most popular choice. LATAM Airlines is also a great choice for the route, with an average price of $732 and an overall rating of 7.5.

  • How does KAYAK find such low prices on flights from Mexico City to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Mexico City to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Mexico City to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Mexico City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Mexico City to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Mexico City with another airline. Booking your flights between Mexico City and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Mexico City to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Mexico City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Mexico City to Santiago

  • Looking for a cheap flight? 25% of our users found flights on this route for $616 or less one-way and $764 or less round-trip.

Prefer to fly direct from Mexico City to Santiago?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Find which airlines fly direct from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport, which days they fly and book direct flights.

Direct departures

Mexico City Benito Juarez to Santiago Arturo Merino Benitez

Monday

LATAM Airlines

LATAM Airlines

Tuesday

LATAM Airlines

LATAM Airlines

Wednesday

LATAM Airlines

LATAM Airlines

Thursday

LATAM Airlines

LATAM Airlines

Friday

LATAM Airlines

LATAM Airlines

Saturday

LATAM Airlines

LATAM Airlines

Sunday

LATAM Airlines

LATAM Airlines

See more direct flights

Direct returns

Santiago Arturo Merino Benitez to Mexico City Benito Juarez

Monday

LATAM Airlines

LATAM Airlines

Tuesday

LATAM Airlines

LATAM Airlines

Wednesday

LATAM Airlines

LATAM Airlines

Thursday

LATAM Airlines

LATAM Airlines

Friday

LATAM Airlines

LATAM Airlines

Saturday

LATAM Airlines

LATAM Airlines

Sunday

LATAM Airlines

LATAM Airlines

See more direct flights

Reviews of the top 3 airlines serving from Mexico City to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Mexico City to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Mexico City to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1562 reviews
7.8Boarding
8.1Crew
6.8Entertainment
7.4Comfort
6.9Food
Airline reviews

Orderly boarding, priority for platinum members, courtesy drinks from business class even when we were seating in economy.

10.0 ExcellentAnonymous, Jun 2026
PTY - BOG
Read more Copa Airlines reviews

Orderly boarding, priority for platinum members, courtesy drinks from business class even when we were seating in economy.

I was flying business class, and the French fellow passengers were super noisy. It was not a comfortable flight. And the crew was not helpful.

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

The flighr attandants were very rude they ignored me didnt offer me anything to drink throughoit the 4 hour flight i feel i was targeted and ignored because i was a darkskin latino man.

No headphones given for inflight entertainment. I missed my flight from the previous day and the customer service agent tried to extort an additional $100.00 US from me for missing my flight. Really?!

It was reasonably comfortable trip considering its duration (7 hours). Crew was very good and friendly, seats very more comfortable than other planes. Only negative comment would be that the bathroom light did not get its full brightness 🙃

Friendly flight team and seamless travel from one stop to next.

I would like a glass of wine or some kind of alcoholic drink.

It's the first time I couldn't check in online because they told me I had to call because there was a problem. Despite having called twice, I had to check in at the airport

other than a slight delay in takeoff from Panama , the flights were excellent ..... we will continue to use Copa whenever possible for flights to and from Central and South America ....

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

We departed and landed on time, the aircraft was clean and comfortable, the crew were lovely. Online checkin worked well and the self service bag drop at the airport worked well. The a/c was an Airbus A330 and has been fitted with a good entertainment system with lots of choice in many languages. The price I paid for the flight was competitive with other airlines apart from the budget carriers, none of whom I was familiar with so I stuck to an airline I have used in previous visits to South America.

I liked everything, this was classed as premium economy but it was much better than Lufthansas business class. Lovely staff, comfortable plane and an excellent seat arrangement. A very pleasant surprise.

The crew was amazing. The best in the last times. Great group of people.

I do not read or speak in Spanish. Only English. When asking for help, the people spoke quickly in English and pointed a lot. I wish they would’ve spoken a little slower for me to understand. There was much confusion and hurried in their message and I was unclear as to where to go

It’s been some time since I saw the plane and the cabin that old and worn out.

I loved how polite the crew was even though some of them wasn't the best with English that they still done everything they could to help me with my needs food was amazing

The flight was overbooked and the solution gave was unrespctful. I arrived 4 hour in advance in the airport and only after 2hous was possible suggest a different ticket with another company LATAM, I have accepted, but when I was checking in at LATAM the tickets was issued without luggage, what it is absurd since I have bought my tickets including it since the beginning. Due to the timing for the next flight was not possible return to Avianca to claim due to the distance between Both companies Avianca and Latam since were located in different terminals. I have insiste to the crew of Latam to call Avianca to solve it, but they could help they were alleging that only paying a thousand pesos Mexicans ($1,000 MXN) to dispatch my luggage would be accepted and I have no money at all. So I had to beg for others passagens, it was an humiliating to exchange luggage with who was platinum in order to return back the luggage in the connection airport in Brazil (GRU). I have no clue that a judicial process would be taken from my side due the lots of stress in sequence by the non professional treatment with a passenger that was just following everything said by Avianca.. Long hours of waiting until next flight and only arrive at final destine in 6hs later..

Both ground crew and flight crew were rude, and did not provide any level of service. They made it very difficult as we were traveling with a passenger the required assistance.

It was OK. The flight is pretty long for the airlines to only offer a simple sandwich on business class. The entertainment is similar to that on other Skyteam members. Ultimately the airline lost my bag and didn’t deliver it to me until the next day after a lengthy lost baggage report.

Good, the flight from Miami to Mexico City was better than Mexico City to Miami

It was good in general. The Crew during the flight were very nice at all times.

Annoying that we had to go to departures and get boarding passes. Should allow us to be booked all the way through, this is the only airline i have this problem with in MEX. Late boarding and take off

the guy in front of me put his seat back immediately...and then left it back including thru landing and taxiing to the runway. attendants did not check/ask him to put it up for landing.

This is not a low cost airline. Stop acting like o e.

Terrible. The flight arrives 2 hr later, no AC. One of the worst flights ever

Boarding - It is unclear where the line for the group are given the signs. A solution would be a diagonal arrow pointing to the lane in which the lane for boarding of a given zone should form. As it is now, you are guessing which side of the pole the "zone 3" sign is telling you to form the line. Inflight Entertainment - The Spanish subtitles function didn't work for movie watching (in fact, all subtitles didn't work), so was difficult to follow along and I watched the movie in silence without words.

An hour-long wait to check in, 90 minutes for luggage to come out, lost luggage, chaotic operations

Everything you need to know for your flight from Mexico City to Santiago

Information on your arrival and departure airports