MEX - SCL

$282 Find Cheap Flights from Mexico City to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Mexico City to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Mexico City to Santiago, as well as popular online travel agencies
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Flights Deals

Cheap Flights from Mexico City to Santiago (MEX-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Mexico City to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Mexico City to Santiago

Tue, Oct 21 - Fri, Oct 31
LATAM Airlines Logo
8:00 pm - 7:40 amMEX-SCL
8h 40mnonstop
LATAM Airlines Logo
9:40 pm - 1:50 pmSCL-MEX
19h 10m1 stop
$516LATAM Airlines
Find Deal
Tue, Jul 29 - Thu, Aug 14
LATAM Airlines Logo
8:00 pm - 6:40 amMEX-SCL
8h 40mnonstop
LATAM Airlines Logo
9:40 pm - 1:50 pmSCL-MEX
18h 10m1 stop
$545LATAM Airlines
Find Deal
Tue, Jul 29 - Thu, Aug 14
Avianca Logo
11:20 pm - 10:30 pmMEX-SCL
21h 10m1 stop
Avianca Logo
2:30 pm - 3:05 amSCL-MEX
14h 35m1 stop
$552Avianca
Find Deal
Mon, Aug 11 - Tue, Aug 19
Avianca Logo
12:40 am - 10:30 pmMEX-SCL
19h 50m1 stop
Avianca Logo
6:10 am - 6:05 pmSCL-MEX
13h 55m1 stop
$553Avianca
Find Deal
Tue, Sep 16 - Tue, Sep 23
LATAM Airlines Logo
8:00 pm - 7:40 amMEX-SCL
8h 40mnonstop
LATAM Airlines Logo
9:20 am - 2:55 pmSCL-MEX
8h 35mnonstop
$554LATAM Airlines
Find Deal
Wed, Oct 8 - Wed, Oct 22
Avianca Logo
12:40 am - 11:30 pmMEX-SCL
19h 50m1 stop
Avianca Logo
3:30 pm - 3:05 amSCL-MEX
14h 35m1 stop
$555Avianca
Find Deal
Mon, Nov 17 - Fri, Nov 28
LATAM Airlines Logo
7:00 pm - 3:30 pmMEX-SCL
17h 30m2 stops
LATAM Airlines Logo
9:20 pm - 3:30 pmSCL-MEX
21h 10m1 stop
$561LATAM Airlines
Find Deal
Mon, Aug 25 - Mon, Sep 1
Copa Airlines Logo
1:40 am - 7:24 pmMEX-SCL
15h 44m1 stop
Copa Airlines Logo
2:26 am - 10:05 pmSCL-MEX
21h 39m1 stop
$563Copa Airlines
Find Deal
Mon, Aug 4 - Tue, Aug 12
Copa Airlines Logo
1:40 am - 7:24 pmMEX-SCL
15h 44m1 stop
Copa Airlines Logo
12:13 am - 2:30 pmSCL-MEX
16h 17m1 stop
$584Copa Airlines
Find Deal
Wed, Aug 20 - Sun, Aug 24
Copa Airlines Logo
1:40 am - 11:08 pmMEX-SCL
19h 28m1 stop
Copa Airlines Logo
2:26 am - 10:05 pmSCL-MEX
21h 39m1 stop
$590Copa Airlines
Find Deal
Expert advice

Expert advice for your flight from Mexico City to Santiago

 
Snippets provided in this section are AI-generated based on a summarization of KAYAK-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Airlines
LATAM Airlines

LATAM's Premium Business offers 1-2-1 seating, ensuring all-aisle access and a 77” long bed.


LATAM Economy's LATAM+ seats provide up to 35” pitch, offering more space on long-haul flights.

Aeromexico

Aeromexico's Clase Premier on 787-9 offers 20” wide seats with 60” pitch for enhanced comfort.


Aeromexico's AM Plus seats provide 38” pitch, offering more comfort in economy class.

Our travel experts
Marisa Garcia

Marisa Garcia

Expert on LATAM Airlines and Aeromexico

Marisa Garcia

Marisa Garcia

Marisa knows planes inside and out, spending 16 years working on aircraft in hangars at airports around the world. She is an aviation industry expert, specialized in airline interiors and regulations. Ten years ago, she pivoted to journalism. She shares her insights in leading aviation, travel, and business publications and on her site FlightChic.

Read more
Useful Info

KAYAK's insights & trends for Mexico City to Santiago flights

Get data-powered insights and trends into flights from Mexico City to Santiago to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Mexico City to Santiago?

What’s the cheapest day of the week to fly from Mexico City to Santiago?

The average price of all round-trip flights from Mexico City to Santiago clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Santiago on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Saturday is the most expensive day to fly from Mexico City to Santiago. For your return ticket, we recommend flying on a Thursday and avoiding Sundays for the best deals.

What is the cheapest month to fly from Mexico City to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Mexico City to Santiago is May, where tickets cost $537 (return) on average. On the other hand, the most expensive months are December and February, where the average cost of round-trip tickets is $728 and $725 respectively.

Can I save money by flying with a layover from Mexico City to Santiago?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $1,151 on average.

How far in advance should I book a flight from Mexico City to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Mexico City to Santiago, you should book around 9 weeks before departure. For the absolute cheapest price, our data suggests you should book 15 weeks before departure.

Good to know

Low seasonJune
High seasonDecember
Cheapest flight$282
Best time to beat the crowds with an average 0% drop in price.
Most popular time to fly with an average 14% increase in price.
Flight from Mexico City to Santiago

When to book flights from Mexico City to Santiago

Are your dates flexible? Find out the best times to travel from Mexico City to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Mexico City to Santiago

  • What is the cheapest flight from Mexico City to Santiago?

    In the last 3 days, the lowest price for a flight from Mexico City to Santiago was $282 for a one-way ticket and $516 for a round-trip.

  • Do I need a passport to fly between Mexico City and Santiago?

    Yes

  • Which airports will I be using when flying from Mexico City to Santiago?

    Mexico City airport is called Mexico City Benito Juarez and the only airport in Santiago is Santiago Arturo Merino Benitez.

  • Which aircraft models fly most regularly from Mexico City to Santiago?

    The Airbus A330 is the aircraft model that flies most regularly on the Mexico City to Santiago flight route.

  • On which days can I fly direct from Mexico City to Santiago?

    There are nonstop flights from Mexico City to Santiago on a daily basis.

  • Which is the best airline for flights from Mexico City to Santiago, LATAM Airlines or Copa Airlines?

    The two airlines most popular with KAYAK users for flights from Mexico City to Santiago are LATAM Airlines and Copa Airlines. With an average price for the route of $689 and an overall rating of 7.5, LATAM Airlines is the most popular choice. Copa Airlines is also a great choice for the route, with an average price of $648 and an overall rating of 7.5.

  • How does KAYAK find such low prices on flights from Mexico City to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Mexico City to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Mexico City to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Mexico City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Mexico City to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Mexico City with another airline. Booking your flights between Mexico City and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Mexico City to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Mexico City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Mexico City to Santiago

  • Looking for a cheap flight? 25% of our users found flights on this route for $589 or less one-way and $654 or less round-trip.

Prefer to fly direct from Mexico City to Santiago?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Find which airlines fly direct from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport, which days they fly and book direct flights.

Direct departures

Mexico City Benito Juarez to Santiago Arturo Merino Benitez

Monday

LATAM Airlines

LATAM Airlines

Tuesday

LATAM Airlines

LATAM Airlines

Wednesday

LATAM Airlines

LATAM Airlines

Thursday

LATAM Airlines

LATAM Airlines

Friday

LATAM Airlines

LATAM Airlines

Saturday

LATAM Airlines

LATAM Airlines

Sunday

LATAM Airlines

LATAM Airlines

See more direct flights

Direct returns

Santiago Arturo Merino Benitez to Mexico City Benito Juarez

Monday

LATAM Airlines

LATAM Airlines

Tuesday

LATAM Airlines

LATAM Airlines

Wednesday

LATAM Airlines

LATAM Airlines

Thursday

LATAM Airlines

LATAM Airlines

Friday

LATAM Airlines

LATAM Airlines

Saturday

LATAM Airlines

LATAM Airlines

Sunday

LATAM Airlines

LATAM Airlines

See more direct flights

Reviews of the top 4 airlines serving from Mexico City to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Mexico City to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Mexico City to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1801 reviews
7.4Comfort
7.0Entertainment
7.6Boarding
8.1Crew
6.7Food
Airline reviews

It was a very good flight, no entertainment is the reason for not checking that box.

10.0 ExcellentAnonymous, Jun 2025REC - GRU
Read more LATAM Airlines reviews

It was a very good flight, no entertainment is the reason for not checking that box.

I travel often with LATAM, it never disappoints me. The service is great, nice crew, latest and some classic movies. I got 3 small meals, cannot complaint. I’ll definitely travel again with them.

We departed and landed on time, the aircraft was clean and comfortable, the crew were lovely. Online checkin worked well and the self service bag drop at the airport worked well. The a/c was an Airbus A330 and has been fitted with a good entertainment system with lots of choice in many languages. The price I paid for the flight was competitive with other airlines apart from the budget carriers, none of whom I was familiar with so I stuck to an airline I have used in previous visits to South America.

We didn’t have any entertainment. I tried to go online without success. The airplane was extremely cold and they didn’t have blankets.

It was good, however the airplane was really cold. We received snacks and the crew was friendly.

Not sure why there are so many security checks at this airport. Consistently annoying showing passport over and over, checking carryons at gate all the while trying to make tight connection. Basically it was uncomfortable crowded cabin with meidiocre service

Change of gate in Santiago devolved into half plus hour delay and a really tight connection in Lima

Although the flight is goof and the crew is good, the way the airline charges you for every service is ridiculous.

Plane never left the ground. Mech issues - entire trip was rerouted through united.

I liked everything, this was classed as premium economy but it was much better than Lufthansas business class. Lovely staff, comfortable plane and an excellent seat arrangement. A very pleasant surprise.

Had to go through security at the gate again. Had to take off shoes and go through the whole thing again even though we have global entry. They asked us to check in items bought at duty free during our layover and since we checked our luggage at the original departure airport, they forced us to check in a small backpack. None of this ever happened with other airlines. In addition, no vegetarian food option and no snacks during a 7 hr flight. Luggage limits are unusually small. This is unacceptable. Will NEVER fly Copa again and will tell friends and family to avoid this airline.

We paid extra with copa for seats near one another The plane was changed and we lost our seats We were all Separated. We have not received a refund for our seats despite emailing and calling.

We had a five hour layover in the way home from Colombia. I read the "bout your flight" email carefully before we checked bags. We had to go through security right at the gate. Almost lost our ground coffee because that airport only allows 16 ounce of coffee and we had 18. I've been to 48 countries and never heard of a coffee restriction. I can't follow a rule I don't know about. I requested they bring our coffee to our checked luggage. Instead tey gate checked our bag for free. Back to planning transfers in Dallas I guess

It was ok. However, the food was quite poor since I don't eat pasta.

Enforce the boarding process by group numbers. Tell people to stay seated during the meal/drink distribution. It took forever to get food and drinks because people would not stay out the isle and let the crew do their jobs. Everyone wanted to go to the bathroom forcing the crew to enter and leave the isle constantly so people can pass. Tell people to keep their electronics off speaker mode. No one wants to hear phone conversations and music playing.

There was no individual at the front check in when I arrived. I waited for at least 15 minutes and walked around asking security/janitors if they could help and they did not have a solution. So I had to take my checked bag through security and they threw away some of my items. I ended up making it to the gate only a few minutes before it closed due to my waiting for an agent at check in.

The flight was delayed twice and I could not speak with anyone at the airport about checking in. The phone number to Copa - the customer service agents were polite. They are just limited at helping because they are not at the airport

We were in transit from Lima (flight at 1.10am) and we were in stand by in our flight from Panama to Washington. We wait from 4.30 am to 18.30pm in the Airport. The company give us 2 x 15 dollars for eat during the day and a personnal travel voucher of 400 dollars each. Do they buy food one time something in the Airport ??? And one of us live in France so the voucher is not usable. More than 24 hours travel !! And our place were near the toilets, with 8 children around us. The boy behind my seat stamped his feet on my back all the flight. Really Wonder full ! So we are totally unhappy with our travel. Thanks Copa Airlines....

My flight delayed and i misss the connection they send me to orlando no to tampa i have to pay a uber to my house

It would have been better if they don't separate families in seating. We were seated in the aile row in the middle of a family of four. It would have been better if they they seat the family of four together than separated.

My flight was delayed, then I got transferred to a new flight that was also delayed- which wasn’t Aeromexico’s fault, it was because of weather conditions. Most of the crew was very nice and patient, except for one or two flight attendants who were rude. The entertainment wasn’t on, so all the screens were off.

My wife's entertainment system did not work. Payed for flight upgrade but did not receive advertised "free WiFi".

Annoying that we had to go to departures and get boarding passes. Should allow us to be booked all the way through, this is the only airline i have this problem with in MEX. Late boarding and take off

the guy in front of me put his seat back immediately...and then left it back including thru landing and taxiing to the runway. attendants did not check/ask him to put it up for landing.

The airplane was an old airplane, seats were very uncomfortable and very little space, they changed my seat and that was no option to get back into my seat even when I was traveling a senior who required assistance.

This is not a low cost airline. Stop acting like o e.

Aeromexico crew made me check my hand luggage in the door of the plane. As soon as I reach Mexico City, I notice that my luggage was opened and 8 games of Nintendo Switch were stolen (700 dllrs value aprox) (the console was there) but the games were stolen. I am very dissapointed of Aeromexico and all the crew. Instead of being a good trip, It was a sad trip

Ok. But we arrived to a remote terminal which meant that a bus had to take us to the terminal building

Old aircraft the audio of the entertainment dosent work Dirty seats

Terrible. The flight arrives 2 hr later, no AC. One of the worst flights ever

Boarding was excessively slow. They do it by groups in a way that it doesn’t make sense. After business class , ppl that need assistance and any other priority group they should have ppl board from the back to the front. First rows 20+. Then 15+. Then 10, etc. having ppl sitting in the back board last makes no sense. The libe backame long as soon as ppl on rows 10 or so where told to board. The line went all the way up the ramp and tunnel for 25 mins.

Seats are very tight even in Plus, no complimentary snacks or beverage

The chicken that was served in business class was cold!

i think the flight was late because they were so strict about measuring everyone's personal items to try and charge them $119. It was really petty and made us late.

A few years ago long flights 6 hours or so used to have video screens and they offered ear phones. The food cart used to come and drinks. Now absolutely nothing. Avianca is as bad as Spirit Airlines. Avianca will now be my last choice when booking my next flight.

Excellent flight and one of the smoothest landing I’ve ever experienced

The seats were very uncomfortable. I would have upgrade or got different flight if I knew. I usually sleep in the plane but I couldn’t sleep at all. Very uncomfortable. Also no food or drink everything was to purchase, and that’s u usual for international flight.

There isn't much space in-between seats and even water needs to be paid for during the flight.

Lounge for business was closed. Boarding was rush and stand by. Seat for business is just the middle seat blocked and some more leg room.

Flew with our two children. Paid $380 to check two bags (one was overweight). They then left the bags behind on Sunday, December 21st, with all our family’s clothes and family Christmas presents. When we arrived at our destination they told us the bags had not arrived, and they thought (but didn’t know) they were still in Boston, but that there’d be a flight the next day and the bags would arrive the next day. The next day we found out there was no flight, now we’re hoping we get our bags before we fly back out. Meanwhile, trying to get any engagement or accurate information is a waste of time. The folks at the call center are just gatekeepers, who can’t connect with any departments that actually do things to solve a problem. Getting information is made deliberately difficult. My biggest regret is that I’ve had a number of awful experiences with Avianca traveling between the US and Colombia, and still let myself get suckered into buying these tickets because the schedule was great. Never again.

Everything you need to know for your flight from Mexico City to Santiago

Information on your arrival and departure airports

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