MEX - SCL

$264 Find Cheap Flights from Mexico City to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 12/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Mexico City to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Mexico City to Santiago, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$473
Overall average: $710
LATAM Airlines
Wed 1/21Wed 1/28
MEX - SCL • Non-stop
Cheapest non-stop
$473
Typical prices: $605-$879
LATAM Airlines
Wed 1/7Wed 1/14
MEX - SCL • Non-stop
Our travelers' advice
AI-generated summary based on content written by travel experts
Aeromexico's AM Plus seats offer 38” pitch in economy.
LATAM's LATAM+ seats provide up to 35” pitch for comfort.
Expert advice
Expert advice
Expert advice
Expert advice
Top airlines
LATAM Airlines
Cheapest • from $473 (round-trip)
Copa Airlines
Best reviews • 7.6 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to book
9 weeks
in advance
Our data shows that travelers who book at least 9 weeks in advance save around 18% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
May
Cheapest • 15% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Expert advice
Flight Deals

Cheap Flights from Mexico City to Santiago (MEX-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Mexico City to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Mexico City to Santiago

Wed, Jan 21 - Wed, Jan 28
LATAM Airlines Logo
7:50 pm - 7:30 amMEX-SCL
8h 40mnonstop
LATAM Airlines Logo
9:10 am - 2:50 pmSCL-MEX
8h 40mnonstop
$473LATAM Airlines
Find Deal
Thu, Dec 4 - Thu, Dec 11
Multiple Airlines Logo
9:00 pm - 10:00 pmMEX-SCL
22h 00m1 stop
Multiple Airlines Logo
5:25 pm - 3:15 pmSCL-MEX
24h 50m1 stop
$515Multiple Airlines
Find Deal
Tue, Dec 2 - Wed, Dec 17
LATAM Airlines Logo
7:50 pm - 7:30 amMEX-SCL
8h 40mnonstop
LATAM Airlines Logo
9:10 am - 2:50 pmSCL-MEX
8h 40mnonstop
$519LATAM Airlines
Find Deal
Wed, Jan 7 - Sun, Jan 25
LATAM Airlines Logo
7:50 pm - 7:30 amMEX-SCL
8h 40mnonstop
LATAM Airlines Logo
9:10 am - 2:50 pmSCL-MEX
8h 40mnonstop
$520LATAM Airlines
Find Deal
Wed, Jan 7 - Sun, Jan 25
Multiple Airlines Logo
7:50 pm - 7:30 amMEX-SCL
8h 40mnonstop
Multiple Airlines Logo
9:24 pm - 11:10 amSCL-MEX
16h 46m1 stop
$524Multiple Airlines
Find Deal
Wed, Jan 21 - Wed, Jan 28
LATAM Airlines Logo
5:15 pm - 12:50 pmMEX-SCL
16h 35m1 stop
LATAM Airlines Logo
10:15 pm - 1:50 pmSCL-MEX
18h 35m1 stop
$525LATAM Airlines
Find Deal
Thu, Jan 29 - Mon, Feb 9
Multiple Airlines Logo
4:00 pm - 2:05 pmMEX-SCL
19h 05m1 stop
Multiple Airlines Logo
9:05 pm - 11:10 amSCL-MEX
17h 05m1 stop
$537Multiple Airlines
Find Deal
Wed, Dec 3 - Tue, Dec 9
Copa Airlines Logo
9:25 am - 11:41 pmMEX-SCL
11h 16m1 stop
Copa Airlines Logo
3:23 am - 7:20 pmSCL-MEX
18h 57m1 stop
$550Copa Airlines
Find Deal
Tue, Dec 2 - Tue, Dec 9
Copa Airlines Logo
2:00 am - 8:21 pmMEX-SCL
15h 21m1 stop
Copa Airlines Logo
3:23 am - 7:20 pmSCL-MEX
18h 57m1 stop
$564Copa Airlines
Find Deal
Wed, Dec 17 - Sat, Jan 31
Aeromexico Logo
10:10 am - 9:15 pmMEX-SCL
8h 05mnonstop
Aeromexico Logo
11:25 pm - 4:50 amSCL-MEX
8h 25mnonstop
$640Aeromexico
Find Deal
Booking Insights

KAYAK's insights & trends for Mexico City to Santiago flights

Get data-powered insights and trends into flights from Mexico City to Santiago to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Mexico City to Santiago?

The average price of all round-trip flights from Mexico City to Santiago clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Santiago on a Tuesday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Mexico City to Santiago. For your return ticket, we recommend flying on a Thursday and avoiding Sundays for the best deals.

What is the cheapest month to fly from Mexico City to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Mexico City to Santiago is May, where tickets cost $533 (return) on average. On the other hand, the most expensive months are February and December, where the average cost of round-trip tickets is $730 and $718 respectively.

Can I save money by flying with a layover from Mexico City to Santiago?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $640, prices are generally cheapest when you fly direct.

How far in advance should I book a flight from Mexico City to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Mexico City to Santiago, you should book around 9 weeks before departure, which saves you about 18% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 23 weeks before departure.

Expert advice

Expert advice for your flight from Mexico City to Santiago

 
Snippets provided in this section are AI-generated based on a summarization of KAYAK-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Airlines
LATAM Airlines

LATAM's Premium Business offers 1-2-1 seating, ensuring all-aisle access and a 77” long bed.


LATAM Economy's LATAM+ seats provide up to 35” pitch, offering more space on long-haul flights.

Aeromexico

Aeromexico's Clase Premier on 787-9 offers 20” wide seats with 60” pitch for enhanced comfort.


Aeromexico's AM Plus seats provide 38” pitch, offering more comfort in economy class.

Our travel experts
Marisa Garcia

Marisa Garcia

Expert on LATAM Airlines and Aeromexico

Marisa Garcia

Marisa Garcia

Marisa knows planes inside and out, spending 16 years working on aircraft in hangars at airports around the world. She is an aviation industry expert, specialized in airline interiors and regulations. Ten years ago, she pivoted to journalism. She shares her insights in leading aviation, travel, and business publications and on her site FlightChic.

Read more

Good to know

Low seasonJune
Cheapest flight$264
Best time to beat the crowds with an average 1% drop in price.
Most popular time to fly with an average 14% increase in price.
Flight from Mexico City to Santiago

When to book flights from Mexico City to Santiago

Are your dates flexible? Find out the best times to travel from Mexico City to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Mexico City to Santiago

  • What is the cheapest flight from Mexico City to Santiago?

    In the last 3 days, the lowest price for a flight from Mexico City to Santiago was $264 for a one-way ticket and $473 for a round-trip.

  • Do I need a passport to fly between Mexico City and Santiago?

    Yes

  • Which airports will I be using when flying from Mexico City to Santiago?

    Mexico City airport is called Mexico City Benito Juarez and the only airport in Santiago is Santiago Arturo Merino Benitez.

  • Which aircraft models fly most regularly from Mexico City to Santiago?

    The Airbus A330 is the aircraft model that flies most regularly on the Mexico City to Santiago flight route.

  • Which airline alliances offer flights from Mexico City to Santiago?

    SkyTeam, and Star Alliance are the airline alliances operating flights between Mexico City and Santiago, with SkyTeam being the most commonly used for this route.

  • On which days can I fly direct from Mexico City to Santiago?

    There are nonstop flights from Mexico City to Santiago on a daily basis.

  • Which is the best airline for flights from Mexico City to Santiago, Copa Airlines or LATAM Airlines?

    The two airlines most popular with KAYAK users for flights from Mexico City to Santiago are Copa Airlines and LATAM Airlines. With an average price for the route of $646 and an overall rating of 7.6, Copa Airlines is the most popular choice. LATAM Airlines is also a great choice for the route, with an average price of $699 and an overall rating of 7.5.

  • How does KAYAK find such low prices on flights from Mexico City to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Mexico City to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Mexico City to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Mexico City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Mexico City to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Mexico City with another airline. Booking your flights between Mexico City and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Mexico City to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Mexico City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Mexico City to Santiago

  • Looking for a cheap flight? 25% of our users found flights on this route for $341 or less one-way and $617 or less round-trip.

Prefer to fly direct from Mexico City to Santiago?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Find which airlines fly direct from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport, which days they fly and book direct flights.

Direct departures

Mexico City Benito Juarez to Santiago Arturo Merino Benitez

Monday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Tuesday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Wednesday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Thursday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Friday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Saturday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Sunday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

See more direct flights

Direct returns

Santiago Arturo Merino Benitez to Mexico City Benito Juarez

Monday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Tuesday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Wednesday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Thursday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Friday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Saturday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

Sunday

Aeromexico, LATAM Airlines

Aeromexico, LATAM Airlines

See more direct flights

Reviews of the top 4 airlines serving from Mexico City to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Mexico City to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Mexico City to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1563 reviews
6.8Entertainment
7.8Boarding
8.1Crew
6.9Food
7.4Comfort
Airline reviews

I always enjoy flying Copa. There are very few airlines where I can enjoy a comfortable sleep in-flight. The snacks weren't the best, but they sufficed. The in-flight entertainment was fantastic, and I crossed another movie off my watch list.

8.0 ExcellentTisagh, Nov 2025SDQ - PTY
Read more Copa Airlines reviews

I always enjoy flying Copa. There are very few airlines where I can enjoy a comfortable sleep in-flight. The snacks weren't the best, but they sufficed. The in-flight entertainment was fantastic, and I crossed another movie off my watch list.

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

They were super friendly bumped me up to exit row free of charge, All flight legs were on time

Boarding was quick & efficient; they gave boarding groups due priority; staff & air crew were very cordial and helpful, pleasant flight.

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

horrible service, food was an embarrassment, no charging for cellphones, stay away

Great experience with a crew always thinking in the passenger

The flighr attandants were very rude they ignored me didnt offer me anything to drink throughoit the 4 hour flight i feel i was targeted and ignored because i was a darkskin latino man.

Very happy with my flight. I would definitely recommend it.

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

The plane broke down at the Lima stopover and they offered to put me on a flight the be t day but I had to be back in LA that morning and so I had to buy another ticket from Avianca and United for $2k I asked LATAM for compensation and received none. Very bad experience

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

Really bad experience – delayed for 6 hours without any notice, no food or drinks provided, and stuck in the horrible Cartagena airport.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

Horrible the worst airlines I have ever flown. Cancelled flight with no choices and when contacted them they were not helpful

Bought a ticket that included a bag and they still charged me to check it in, latam is the worst airline.

Good, the flight from Miami to Mexico City was better than Mexico City to Miami

Flight was on time, good service, but there was no free WiFi, even for first class passengers

It was good in general. The Crew during the flight were very nice at all times.

The ground staff were not as friendly and nice to the passengers as the air crew. Flight attendants, cockpit crew were great and very nice to everyone on board.

My flight was delayed, then I got transferred to a new flight that was also delayed- which wasn’t Aeromexico’s fault, it was because of weather conditions. Most of the crew was very nice and patient, except for one or two flight attendants who were rude. The entertainment wasn’t on, so all the screens were off.

My wife's entertainment system did not work. Payed for flight upgrade but did not receive advertised "free WiFi".

Annoying that we had to go to departures and get boarding passes. Should allow us to be booked all the way through, this is the only airline i have this problem with in MEX. Late boarding and take off

the guy in front of me put his seat back immediately...and then left it back including thru landing and taxiing to the runway. attendants did not check/ask him to put it up for landing.

The airplane was an old airplane, seats were very uncomfortable and very little space, they changed my seat and that was no option to get back into my seat even when I was traveling a senior who required assistance.

This is not a low cost airline. Stop acting like o e.

Horrible experience. Flight cancelled. Arrived at destination 12 hs later. No one gave us an answer or any information. Very very poor service. We won’t ever travel again with Avianca

Did not fly with Pakistan International Airlines. Have never flown with Pakistan International Airlines.

Usb plugs for charging your phone does not work in every flight. uncomfortable chairs even in higher categories.

The seats were uncomfortable and barely reclined at all. Very little leg room despite being business class. The crew was friendly and the food was good. Had to use my own phone for in-flight entertainment.

Avianca is not what it used to be. So disappointing

why did we have to go through security mid flight

Seats are very tight even in Plus, no complimentary snacks or beverage

Terrible, We had to stay in Bogota for two days due to weather but the airline did not provide for the same day flight. Only two days later

Excellent flight and one of the smoothest landing I’ve ever experienced

There isn't much space in-between seats and even water needs to be paid for during the flight.

Everything you need to know for your flight from Mexico City to Santiago

Information on your arrival and departure airports