MEX - SCL

$264 Find Cheap Flights from Mexico City to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Mexico City to Santiago departing on 10/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Mexico City to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Mexico City to Santiago, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Mexico City to Santiago (MEX-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Mexico City to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Mexico City to Santiago

Tue, Sep 16 - Thu, Sep 25
Avianca Logo
2:00 pm - 5:15 amMEX-SCL
12h 15m1 stop
Avianca Logo
12:55 am - 12:05 pmSCL-MEX
14h 10m1 stop
$535Avianca
Find Deal
Wed, Sep 17 - Thu, Sep 25
Avianca Logo
2:00 pm - 5:15 amMEX-SCL
12h 15m1 stop
Avianca Logo
3:30 pm - 3:05 amSCL-MEX
14h 35m1 stop
$539Avianca
Find Deal
Tue, Sep 16 - Thu, Sep 25
LATAM Airlines Logo
8:00 pm - 7:40 amMEX-SCL
8h 40mnonstop
LATAM Airlines Logo
1:40 am - 2:55 pmSCL-MEX
16h 15m1 stop
$540LATAM Airlines
Find Deal
Tue, Sep 30 - Wed, Oct 15
 Logo
7:05 pm - 1:20 pmMEX-SCL
15h 15m2 stops
 Logo
11:11 am - 1:50 pmSCL-MEX
29h 39m2 stops
Sun, Nov 16 - Thu, Nov 27
Avianca Logo
12:40 am - 12:30 amMEX-SCL
20h 50m1 stop
Avianca Logo
1:35 am - 6:10 pmSCL-MEX
19h 35m1 stop
$549Avianca
Find Deal
Sun, Sep 14 - Fri, Sep 26
Copa Airlines Logo
5:50 am - 8:20 pmMEX-SCL
11h 30m1 stop
Copa Airlines Logo
5:11 am - 2:30 pmSCL-MEX
12h 19m1 stop
$553Copa Airlines
Find Deal
Fri, Sep 26 - Fri, Oct 3
Avianca Logo
2:00 pm - 5:15 amMEX-SCL
12h 15m1 stop
Avianca Logo
3:30 pm - 3:05 amSCL-MEX
14h 35m1 stop
$560Avianca
Find Deal
Fri, Sep 12 - Fri, Sep 19
Copa Airlines Logo
1:05 pm - 3:42 amMEX-SCL
11h 37m1 stop
Copa Airlines Logo
12:29 pm - 1:00 amSCL-MEX
15h 31m1 stop
$563Copa Airlines
Find Deal
Mon, Nov 17 - Fri, Nov 28
LATAM Airlines Logo
6:55 pm - 3:30 pmMEX-SCL
17h 35m2 stops
LATAM Airlines Logo
9:15 am - 2:55 pmSCL-MEX
8h 40mnonstop
$579LATAM Airlines
Find Deal
Tue, Sep 30 - Mon, Nov 10
 Logo
7:05 pm - 1:20 pmMEX-SCL
15h 15m2 stops
 Logo
6:35 pm - 3:15 pmSCL-MEX
23h 40m1 stop
Expert advice

Expert advice for your flight from Mexico City to Santiago

 
Snippets provided in this section are AI-generated based on a summarization of KAYAK-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Airlines
LATAM Airlines

LATAM's Premium Business offers 1-2-1 seating, ensuring all-aisle access and a 77” long bed.


LATAM Economy's LATAM+ seats provide up to 35” pitch, offering more space on long-haul flights.

Aeromexico

Aeromexico's Clase Premier on 787-9 offers 20” wide seats with 60” pitch for enhanced comfort.


Aeromexico's AM Plus seats provide 38” pitch, offering more comfort in economy class.

Our travel experts
Marisa Garcia

Marisa Garcia

Expert on LATAM Airlines and Aeromexico

Marisa Garcia

Marisa Garcia

Marisa knows planes inside and out, spending 16 years working on aircraft in hangars at airports around the world. She is an aviation industry expert, specialized in airline interiors and regulations. Ten years ago, she pivoted to journalism. She shares her insights in leading aviation, travel, and business publications and on her site FlightChic.

Read more
Booking Insights

KAYAK's insights & trends for Mexico City to Santiago flights

Get data-powered insights and trends into flights from Mexico City to Santiago to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Mexico City to Santiago?

The average price of all round-trip flights from Mexico City to Santiago clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Santiago on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Saturday is the most expensive day to fly from Mexico City to Santiago. For your return ticket, we recommend flying on a Thursday and avoiding Sundays for the best deals.

What is the cheapest month to fly from Mexico City to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Mexico City to Santiago is May, where tickets cost $536 (return) on average. On the other hand, the most expensive months are December and February, where the average cost of round-trip tickets is $730 and $722 respectively.

Can I save money by flying with a layover from Mexico City to Santiago?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $1,212 on average.

How far in advance should I book a flight from Mexico City to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Mexico City to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Mexico City to Santiago, you should book around 9 weeks before departure, which saves you about 16% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 23 weeks before departure.

Good to know

Low seasonJune
Cheapest flight$264
Best time to beat the crowds with an average 3% drop in price.
Most popular time to fly with an average 15% increase in price.
Flight from Mexico City to Santiago

When to book flights from Mexico City to Santiago

Are your dates flexible? Find out the best times to travel from Mexico City to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Mexico City to Santiago

  • What is the cheapest flight from Mexico City to Santiago?

    In the last 3 days, the lowest price for a flight from Mexico City to Santiago was $264 for a one-way ticket and $535 for a round-trip.

  • Do I need a passport to fly between Mexico City and Santiago?

    Yes

  • Which airports will I be using when flying from Mexico City to Santiago?

    Mexico City airport is called Mexico City Benito Juarez and the only airport in Santiago is Santiago Arturo Merino Benitez.

  • Which aircraft models fly most regularly from Mexico City to Santiago?

    The Airbus A330 is the aircraft model that flies most regularly on the Mexico City to Santiago flight route.

  • On which days can I fly direct from Mexico City to Santiago?

    There are nonstop flights from Mexico City to Santiago on a daily basis.

  • Which is the best airline for flights from Mexico City to Santiago, LATAM Airlines or Aeromexico?

    The two airlines most popular with KAYAK users for flights from Mexico City to Santiago are LATAM Airlines and Aeromexico. With an average price for the route of $686 and an overall rating of 7.5, LATAM Airlines is the most popular choice. Aeromexico is also a great choice for the route, with an average price of $767 and an overall rating of 7.5.

  • How does KAYAK find such low prices on flights from Mexico City to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Mexico City to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Mexico City to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Mexico City is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Mexico City to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Mexico City with another airline. Booking your flights between Mexico City and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Mexico City to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Mexico City up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Mexico City to Santiago

  • Looking for a cheap flight? 25% of our users found flights on this route for $582 or less one-way and $602 or less round-trip.

Prefer to fly direct from Mexico City to Santiago?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Find which airlines fly direct from Mexico City Benito Juarez Airport to Santiago Arturo Merino Benitez Airport, which days they fly and book direct flights.

Direct departures

Mexico City Benito Juarez to Santiago Arturo Merino Benitez

Monday

LATAM Airlines, Aeromexico

LATAM Airlines, Aeromexico

Tuesday

LATAM Airlines, Aeromexico

LATAM Airlines, Aeromexico

Wednesday

LATAM Airlines, Aeromexico

LATAM Airlines, Aeromexico

Thursday

LATAM Airlines, Aeromexico

LATAM Airlines, Aeromexico

Friday

LATAM Airlines, Aeromexico

LATAM Airlines, Aeromexico

Saturday

LATAM Airlines, Aeromexico

LATAM Airlines, Aeromexico

Sunday

LATAM Airlines, Aeromexico

LATAM Airlines, Aeromexico

See more direct flights

Direct returns

Santiago Arturo Merino Benitez to Mexico City Benito Juarez

Monday

LATAM Airlines, Aeromexico, WestJet

LATAM Airlines, Aeromexico, +1 more

Tuesday

LATAM Airlines, Aeromexico, WestJet

LATAM Airlines, Aeromexico, +1 more

Wednesday

LATAM Airlines, Aeromexico, WestJet

LATAM Airlines, Aeromexico, +1 more

Thursday

LATAM Airlines, Aeromexico, WestJet

LATAM Airlines, Aeromexico, +1 more

Friday

LATAM Airlines, Aeromexico, WestJet

LATAM Airlines, Aeromexico, +1 more

Saturday

LATAM Airlines, Aeromexico, WestJet

LATAM Airlines, Aeromexico, +1 more

Sunday

LATAM Airlines, Aeromexico, WestJet

LATAM Airlines, Aeromexico, +1 more

See more direct flights

Reviews of the top 4 airlines serving from Mexico City to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Mexico City to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Mexico City to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1840 reviews
7.4Comfort
7.0Entertainment
8.0Crew
6.7Food
7.6Boarding
Airline reviews

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

6.0 GoodAnonymous, Aug 2025JFK - GRU
Read more LATAM Airlines reviews

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

Horrible the worst airlines I have ever flown. Cancelled flight with no choices and when contacted them they were not helpful

Bought a ticket that included a bag and they still charged me to check it in, latam is the worst airline.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

My entertainment did not work. I was very tired from the botched connection, and the poor sleep

Boarding was done by woman who insisted on strict standing in line policy; food was ok; entertainment minimal

entertainment was not good; the shoulder strap on Business class seat did not sit well across the body (more like across the neck); the food was not hot and the special meal promoted by insert in the menu was not available to us

Our flight was cancelled and it took them 5 hours to reschedule and the next morning they said we still didn’t have a new ticket.

I travel often with LATAM, it never disappoints me. The service is great, nice crew, latest and some classic movies. I got 3 small meals, cannot complaint. I’ll definitely travel again with them.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

horrible service, food was an embarrassment, no charging for cellphones, stay away

Great experience with a crew always thinking in the passenger

The flighr attandants were very rude they ignored me didnt offer me anything to drink throughoit the 4 hour flight i feel i was targeted and ignored because i was a darkskin latino man.

Very happy with my flight. I would definitely recommend it.

Did upgrade, travel in business it was great (more room I could sleep)

Had to go through security at the gate again. Had to take off shoes and go through the whole thing again even though we have global entry. They asked us to check in items bought at duty free during our layover and since we checked our luggage at the original departure airport, they forced us to check in a small backpack. None of this ever happened with other airlines. In addition, no vegetarian food option and no snacks during a 7 hr flight. Luggage limits are unusually small. This is unacceptable. Will NEVER fly Copa again and will tell friends and family to avoid this airline.

Seats not reclining, no vegetarian food option, no snacks. 7.5 hr flight should have been more comfortable. Luggage limits are unusually small. Will never fly Copa again and will tell friends and family to avoid this airline.

We paid extra with copa for seats near one another The plane was changed and we lost our seats We were all Separated. We have not received a refund for our seats despite emailing and calling.

We had a five hour layover in the way home from Colombia. I read the "bout your flight" email carefully before we checked bags. We had to go through security right at the gate. Almost lost our ground coffee because that airport only allows 16 ounce of coffee and we had 18. I've been to 48 countries and never heard of a coffee restriction. I can't follow a rule I don't know about. I requested they bring our coffee to our checked luggage. Instead tey gate checked our bag for free. Back to planning transfers in Dallas I guess

Good, the flight from Miami to Mexico City was better than Mexico City to Miami

Flight was on time, good service, but there was no free WiFi, even for first class passengers

It was good in general. The Crew during the flight were very nice at all times.

The ground staff were not as friendly and nice to the passengers as the air crew. Flight attendants, cockpit crew were great and very nice to everyone on board.

My flight was delayed, then I got transferred to a new flight that was also delayed- which wasn’t Aeromexico’s fault, it was because of weather conditions. Most of the crew was very nice and patient, except for one or two flight attendants who were rude. The entertainment wasn’t on, so all the screens were off.

My wife's entertainment system did not work. Payed for flight upgrade but did not receive advertised "free WiFi".

Annoying that we had to go to departures and get boarding passes. Should allow us to be booked all the way through, this is the only airline i have this problem with in MEX. Late boarding and take off

the guy in front of me put his seat back immediately...and then left it back including thru landing and taxiing to the runway. attendants did not check/ask him to put it up for landing.

The airplane was an old airplane, seats were very uncomfortable and very little space, they changed my seat and that was no option to get back into my seat even when I was traveling a senior who required assistance.

This is not a low cost airline. Stop acting like o e.

The check in is the only positive thing in Avianca. The seat is the most uncomfortable I have traveled, the distance is minimal.

why did we have to go through security mid flight

The incoming plane was late and no information was shared. They even announced we would board in 10 muntes 40 minutes prior to the plane arriving, and the website said until takeoff that we had taken off an hour earlier

Boarding was excessively slow. They do it by groups in a way that it doesn’t make sense. After business class , ppl that need assistance and any other priority group they should have ppl board from the back to the front. First rows 20+. Then 15+. Then 10, etc. having ppl sitting in the back board last makes no sense. The libe backame long as soon as ppl on rows 10 or so where told to board. The line went all the way up the ramp and tunnel for 25 mins.

Seats are very tight even in Plus, no complimentary snacks or beverage

Terrible, We had to stay in Bogota for two days due to weather but the airline did not provide for the same day flight. Only two days later

Excellent flight and one of the smoothest landing I’ve ever experienced

There isn't much space in-between seats and even water needs to be paid for during the flight.

Lounge for business was closed. Boarding was rush and stand by. Seat for business is just the middle seat blocked and some more leg room.

Flew with our two children. Paid $380 to check two bags (one was overweight). They then left the bags behind on Sunday, December 21st, with all our family’s clothes and family Christmas presents. When we arrived at our destination they told us the bags had not arrived, and they thought (but didn’t know) they were still in Boston, but that there’d be a flight the next day and the bags would arrive the next day. The next day we found out there was no flight, now we’re hoping we get our bags before we fly back out. Meanwhile, trying to get any engagement or accurate information is a waste of time. The folks at the call center are just gatekeepers, who can’t connect with any departments that actually do things to solve a problem. Getting information is made deliberately difficult. My biggest regret is that I’ve had a number of awful experiences with Avianca traveling between the US and Colombia, and still let myself get suckered into buying these tickets because the schedule was great. Never again.

Everything you need to know for your flight from Mexico City to Santiago

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