MYR - STL

$146 Find Cheap Flights from Myrtle Beach to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Myrtle Beach to St. Louis departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Myrtle Beach to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$355
Typical prices: $364-$179
Delta
Wed 6/24Tue 6/30
MYR - STL • 1 stop
Cheapest non-stop
$408
Southwest
Fri 8/28Mon 8/31
MYR - STL • Non-stop
Advice from real travelers
AI-powered summary based on content written by travel experts. AI can make mistakes.
MYR's terminals are easy to navigate with kiosks.
Use MetroLink for easy access from Lambert-St Louis.
Expert advice
Expert advice
Expert advice
Expert advice
Nonstop flights
5 days a week
Mon, Thu, Fri, Sat, Sun
You can fly direct with Southwest. Average duration is 2h 05m
Direct flights
Direct flights
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Direct flights
Direct flights
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Top airlines
Cheapest • from $355 (round-trip)
Best reviews • 8.0 score
Airline reviews
Airline reviews
+1
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Airline reviews
Airline reviews
+1
When to travel
Cheapest • 37% price drop
Most popular
Good to know
Good to know
+1
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Good to know
Good to know
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Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Expert advice
Flight Deals

Cheap Flights from Myrtle Beach to St. Louis (MYR-STL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Myrtle Beach to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Myrtle Beach to St. Louis

Wed, Jun 24 - Tue, Jun 30
Delta Logo
6:00 am - 9:46 am
MYR
-
STL
4h 46m
1 stop
Delta Logo
10:51 am - 3:29 pm
STL
-
MYR
3h 38m
1 stop
$355Delta
Wed, Jun 24 - Tue, Jun 30
American Airlines Logo
6:06 pm - 12:16 am
MYR
-
STL
7h 10m
2 stops
American Airlines Logo
10:45 am - 5:39 pm
STL
-
MYR
5h 54m
1 stop
$360American Airlines
Fri, Aug 28 - Mon, Aug 31
Delta Logo
2:18 pm - 5:53 pm
MYR
-
STL
4h 35m
1 stop
Delta Logo
6:00 am - 10:47 am
STL
-
MYR
3h 47m
1 stop
$364Delta
Wed, Jun 24 - Tue, Jun 30
American Airlines Logo
6:06 pm - 12:16 am
MYR
-
STL
7h 10m
2 stops
American Airlines Logo
2:32 pm - 9:46 pm
STL
-
MYR
6h 14m
2 stops
$366American Airlines
Thu, Sep 17 - Sun, Sep 20
Southwest Logo
6:15 pm - 9:40 pm
MYR
-
STL
4h 25m
1 stop
Southwest Logo
12:30 pm - 9:25 pm
STL
-
MYR
7h 55m
2 stops
$369Southwest
Thu, Sep 17 - Sun, Sep 20
Southwest Logo
3:20 pm - 9:40 pm
MYR
-
STL
7h 20m
1 stop
Southwest Logo
3:15 pm - 6:10 pm
STL
-
MYR
1h 55mnonstop
$374Southwest
Tue, Jul 7 - Tue, Jul 14
Southwest Logo
10:25 am - 6:20 pm
MYR
-
STL
8h 55m
2 stops
Southwest Logo
11:20 am - 8:35 pm
STL
-
MYR
8h 15m
2 stops
$378Southwest
Thu, Jun 18 - Mon, Jun 22
Southwest Logo
7:25 am - 12:10 pm
MYR
-
STL
5h 45m
1 stop
Southwest Logo
10:00 am - 6:35 pm
STL
-
MYR
7h 35m
2 stops
$392Southwest
Fri, Jul 17 - Mon, Jul 20
Southwest Logo
7:25 am - 12:10 pm
MYR
-
STL
5h 45m
1 stop
Southwest Logo
3:35 pm - 10:50 pm
STL
-
MYR
6h 15m
1 stop
$396Southwest
Fri, Aug 28 - Mon, Aug 31
Southwest Logo
2:30 pm - 7:10 pm
MYR
-
STL
5h 40m
1 stop
Southwest Logo
10:15 am - 1:10 pm
STL
-
MYR
1h 55mnonstop
$398Southwest
Booking Insights

KAYAK's insights & trends for Myrtle Beach to St. Louis flights

Get data-powered insights and trends into flights from Myrtle Beach to St. Louis to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Myrtle Beach to St. Louis?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Myrtle Beach to St. Louis departing in June.

What’s the cheapest day of the week to fly from Myrtle Beach to St. Louis?

The average price of all round-trip flights from Myrtle Beach to St. Louis clicked on KAYAK for each day over the last 12 months.

When flying from Myrtle Beach to St. Louis, you should consider leaving on a Saturday and avoid Sundays if you are looking for the best rates. For your return to Myrtle Beach, you’ll find the best rates on Saturdays and the most expensive ones on Sundays.

What is the cheapest month to fly from Myrtle Beach to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Myrtle Beach to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Myrtle Beach to St. Louis is August, where tickets cost $225 (return) on average. On the other hand, the most expensive months are December and May, where the average cost of round-trip tickets is $484 and $436 respectively.

Can I save money by flying with a layover from Myrtle Beach to St. Louis?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $260, prices are generally cheapest when you fly direct.

Expert advice

Expert advice for your flight from Myrtle Beach to St. Louis

 
AI-powered summary based on content written by travel experts. AI can make mistakes.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Our travel experts
Ramsey Qubein

Ramsey Qubein

Expert on MYR

An avid traveler and aviation expert who has visited 173 countries, all 50 states and seven continents, Ramsey Qubein flies nearly 400,000 miles a year. As a North Carolina-based freelance journalist for publications including Conde Nast Traveler, Forbes, USA Today and Bloomberg among others, he explores the latest trends in aviation, hospitality, cruises and business.

Yulia Denisyuk

Yulia Denisyuk

Expert on STL

Yulia is a freelance journalist who’s dispatched from 90+ countries. Her work focuses on cultures, adventure trips and air travel, appearing in NatGeo, NYT, CNTraveler, and more. For past assignments, she’s stayed with nomads in Mongolia and learned the art of Imigongo in Rwanda. She’s based in Chicago; in winter she often questions that decision.

Good to know

Low seasonOctober
Cheapest flight$146
Best time to beat the crowds with an average 22% drop in price.
Most popular time to fly and prices are also 9% lower on average.
Flight from Myrtle Beach to St. Louis

When to book flights from Myrtle Beach to St. Louis

Are your dates flexible? Find out the best times to travel from Myrtle Beach to St. Louis based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Myrtle Beach to St. Louis

  • What is the cheapest flight from Myrtle Beach to St. Louis?

    In the last 3 days, the lowest price for a flight from Myrtle Beach to St. Louis was $146 for a one-way ticket and $355 for a round-trip.

  • Do I need a passport to fly between Myrtle Beach and St. Louis?

    A passport is not required to fly from Myrtle Beach to St. Louis.

  • Which airports will I be using when flying from Myrtle Beach to St. Louis?

    On your way to St. Louis, you’ll fly out from Myrtle Beach Intl. You’ll be landing at Lambert-St Louis.

  • Which airlines offer Wi-Fi service onboard planes from Myrtle Beach to St. Louis?

    Delta, and American Airlines offer inflight Wi-Fi service on the Myrtle Beach to St. Louis flight route.

  • Which aircraft models fly most regularly from Myrtle Beach to St. Louis?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Myrtle Beach to St. Louis flight route.

  • Which airline alliances offer flights from Myrtle Beach to St. Louis?

    SkyTeam, and oneworld are the airline alliances operating flights between Myrtle Beach and St. Louis, with SkyTeam being the most commonly used for this route.

  • On which days can I fly direct from Myrtle Beach to St. Louis?

    You can catch a nonstop flight from Myrtle Beach to St. Louis on on Monday, Thursday, Friday, Saturday, and Sunday.

  • Which is the best airline for flights from Myrtle Beach to St. Louis, Southwest or Delta?

    The two airlines most popular with KAYAK users for flights from Myrtle Beach to St. Louis are Southwest and Delta. With an average price for the route of $361 and an overall rating of 8.0, Southwest is the most popular choice. Delta is also a great choice for the route, with an average price of $350 and an overall rating of 7.9.

  • How does KAYAK find such low prices on flights from Myrtle Beach to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Myrtle Beach to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Myrtle Beach to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis from Myrtle Beach is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Myrtle Beach to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back to Myrtle Beach with another airline. Booking your flights between Myrtle Beach and STL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Myrtle Beach to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis from Myrtle Beach up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Myrtle Beach to St. Louis

  • Looking for a cheap flight? 25% of our users found flights on this route for $375 or less round-trip.

Prefer to fly direct from Myrtle Beach to St. Louis?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Myrtle Beach Intl to Lambert-St Louis.
Find which airlines fly direct from Myrtle Beach Intl Airport to Lambert-St Louis Airport, which days they fly and book direct flights.

Direct departures

Myrtle Beach Intl to Lambert-St Louis

Monday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Direct returns

Lambert-St Louis to Myrtle Beach Intl

Monday

Southwest

Southwest

Thursday

Southwest

Southwest

Friday

Southwest

Southwest

Saturday

Southwest

Southwest

Sunday

Southwest

Southwest

See more direct flights

Reviews of the top 3 airlines serving from Myrtle Beach to St. Louis

 
See real verified KAYAK customer reviews for airlines flying from Myrtle Beach to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Myrtle Beach to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4266 reviews
8.6Crew
8.1Boarding
7.0Food
8.0Comfort
7.5Entertainment
Airline reviews

The first time I flew in the extra legroom section. It was difficult to notice a difference. I had bad luck with my neighbors. The crew was okay. Southwest has reduced the live TV options.

4.0 OkayAnonymous, May 2026
MDW - LAX
Read more Southwest reviews

The first time I flew in the extra legroom section. It was difficult to notice a difference. I had bad luck with my neighbors. The crew was okay. Southwest has reduced the live TV options.

The flight was smooth. The Southwest experience has degraded overall, but this one was okay.

No gluten free snacks. Seats felt worn or bare bones even though it was a new 737 MAX 8.

One major problem that was very unprofessional and uncalled for. Plane landed and we had to wait 20 minutes to get off the plane since they were waiting for someone to come to the gate to drive the jetway. Southwest couldn't have someone available and waiting for the plane to land? Is there only one person in Hobby airport who knows to drive the jetway? Was he at lunch? In the bar? Uncomfortable and uncalled for!

The checking experience in Orlando was terrible, almost missed the flight. Too many travelers and Southwest completely understaffed.

I'm glad it wasn't only 75% full because I could get a good seat

if I was good. Not happy that I have to pay extra money to get the seat I need for lake room, but I guess that’s a sign of the times.

Seats were very comfortable. They tilted back. Drinks and snacks were free and served 3 times. Attendants were awesome.

Plane was clean and comfortable. Flight attendants and gate staff were professional, friendly and efficient. Boarding and deplaning were orderly and efficient. All in all, the typical excellent Southwest experience.

Truly terrible. Will never willingly fly southwest again. Seats are worse than before they switched to assigned seating. One flight attendant was the opposite of helpful (rude, unhelpful, dismissive, and as my stranger seatmate said unprompted: a total prick). This caused me, 15 minutes into the flight, to book an alternate return flight home on a competing airline (first class 1.2k purchase instead of my existing planned flight) just so I would not have to ever be on that aircraft, with that terrible service person, with those horrific seats ever again.

Planes were clean, no water or snacks on either flight.

Free & relatively fast Wi-Fi. Would've liked a wider drink selection.

I continue to be satisfied with Delta’s excellent service out of LGA. The digit id works well and gets me through security in no time. Whenever possible, I choose Delta.

Was revoked with Jet Blue due to delay from Kenya Air

Enjoyed it very much. Especially liked the free WiFi that Delta offers.

Smooth flight. Left on time, and got in 15 minutes early. Onboard video was great

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

WiFi didn’t work on two of four planes. Flight attendants were not overly friendly or welcoming. Planes were extremely slow to board and deplane.

Delta does a great job with entertainment and free wifi. I can still be in touch with my colleagues while in the air.

Aside from a completely packed plane, I really have no complaints.

Ontario airport boarding was very easy to park and access, is clean and TSA took 10 minutes total. Check-in was a breeze and cruise was very nice.

American Airlines II: Delay Boogaloo. Multiple gate changes, delays, boarded and then MORE delays. I hate to say this won’t matter, but posting stuff about major corporations in 2026 is a post-modern “scream into the void.” Was multiple hours late coming home, so there you go.

Awful, tons of delays, I got into Chicago multiple hours late meaning I hit the very traffic I tried so desperately to avoid. Just empty apologies from American Airlines text alerts. Trash behavior from a trash airline.

The flight attendants were very friendly, efficient, and helpful. The plane was ahead of schedule, and it all went very smoothly. Thank you.

They lost my baggage and I am still struggling to the information and update

We got delayed getting out of DFW for broken overhead bins. Once the flight got underway the captain kept the seatbelt sign lit the entire flight despite little perceptible turbulence, preventing use of the rest rooms and any sort of refreshment service in the main cabin.

Flight delays for communication overall not a good experience uncomfortable on the plane. Person in front of me reclined his seat, putting them inches from my lap.

There were flight delays making our flight arrive at our destination after midnight didn’t seem to have enough crew or airplanes for the flights laid over in Dallas should’ve had plenty of time to make it to our next flight only made it because that flight was also delayed because our plane wasn’t even at the airport yet overall have not had a good experience on American

Flight left on time. Captain provided relevant announcements. We had to wait 45 minutes to desembark due to the ramp closed because of lightening.

Cancelled flight. Still waiting to get home for grand daughter’s graduation .

Everything you need to know for your flight from Myrtle Beach to St. Louis

Information on your arrival and departure airports