$350 Find Cheap Flights from Panama City to Mexico City Federal District

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Mexico City Federal District departing on 9/24. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Mexico City Federal District

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Mexico City Federal District, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to Mexico City Federal District, as well as popular online travel agencies
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Flight Deals

Book Cheap Panama City to Mexico City Federal District Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Mexico City Federal District that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Mexico City Federal District

Tue, May 12 - Tue, May 19
United Airlines Logo
2:14 pm - 11:10 pm
ECP
-
MEX
9h 56m
2 stops
United Airlines Logo
2:15 pm - 10:05 pm
MEX
-
ECP
6h 50m
1 stop
$624United Airlines
Wed, May 20 - Mon, May 25
Delta Logo
9:19 am - 8:15 pm
ECP
-
MEX
11h 56m
2 stops
Delta Logo
8:30 am - 7:09 pm
MEX
-
ECP
9h 39m
2 stops
$629Delta
Fri, Jun 5 - Tue, Jun 9
Aeromexico Logo
6:00 am - 8:15 pm
ECP
-
MEX
15h 15m
2 stops
Aeromexico Logo
8:40 am - 4:23 pm
MEX
-
ECP
6h 43m
1 stop
$644Aeromexico
Sat, Jul 11 - Mon, Jul 20
Delta Logo
6:00 am - 3:30 pm
ECP
-
MEX
10h 30m
2 stops
Delta Logo
9:00 am - 11:37 pm
MEX
-
ECP
13h 37m
2 stops
$649Delta
Fri, Jun 5 - Tue, Jun 9
Aeromexico Logo
6:00 am - 4:05 pm
ECP
-
MEX
11h 05m
2 stops
Aeromexico Logo
6:50 am - 11:44 pm
MEX
-
ECP
15h 54m
2 stops
$664Aeromexico
Fri, Jul 31 - Sun, Aug 2
United Airlines Logo
6:30 am - 10:45 am
ECP
-
MEX
5h 15m
1 stop
United Airlines Logo
4:40 am - 8:01 pm
MEX
-
ECP
14h 21m
1 stop
$682United Airlines
Sun, May 24 - Sun, May 31
United Airlines Logo
5:05 pm - 11:10 pm
ECP
-
MEX
7h 05m
1 stop
United Airlines Logo
6:30 am - 4:23 pm
MEX
-
ECP
8h 53m
1 stop
$684United Airlines
Sun, May 24 - Sun, May 31
Delta Logo
7:41 am - 6:50 pm
ECP
-
MEX
12h 09m
2 stops
Delta Logo
8:40 am - 7:09 pm
MEX
-
ECP
9h 29m
1 stop
$689Delta
Wed, Apr 29 - Fri, May 8
American Airlines Logo
7:00 am - 4:15 pm
ECP
-
MEX
10h 15m
1 stop
American Airlines Logo
7:00 am - 9:58 pm
MEX
-
ECP
13h 58m
1 stop
$709American Airlines
Wed, Apr 29 - Fri, May 8
American Airlines Logo
7:21 am - 8:45 pm
ECP
-
MEX
14h 24m
2 stops
American Airlines Logo
5:00 am - 9:58 pm
MEX
-
ECP
15h 58m
1 stop
$714American Airlines
Booking Insights

KAYAK's insights & trends for Panama City to Mexico City Federal District flights

Get data-powered insights and trends into flights from Panama City to Mexico City Federal District to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Panama City to Mexico City Federal District?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Panama City to Mexico City Federal District were found on United Airlines ($624) and Delta ($629).

Good to know

Low seasonSeptember
Cheapest flight$350
Best time to beat the crowds with an average 20% drop in price.
Most popular time to fly and prices are also 12% lower on average.
Flight from Panama City to Mexico City

FAQs - booking Mexico City Federal District flights

  • How does KAYAK find such low prices on flights from Panama City to Mexico City Federal District?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Mexico City Federal District.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Mexico City Federal District?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to Mexico City Federal District is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Mexico City Federal District?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to Mexico City Federal District with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Mexico City Federal District?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to Mexico City Federal District up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to Mexico City Federal District

 
See real verified KAYAK customer reviews for airlines flying from Panama City to Mexico City Federal District. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to Mexico City Federal District? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8406 reviews
7.9Comfort
7.2Food
8.5Crew
7.8Entertainment
8.1Boarding
Airline reviews

Crew was great. Near on time departure and early arrival. Snacks are always meh. Not a fan of the "pay for everything including miles " proposal unless base flight rate going to be 100 bucks.

4.0 OkayRay, Apr 2026
EYW - ATL
Read more Delta reviews

Crew was great. Near on time departure and early arrival. Snacks are always meh. Not a fan of the "pay for everything including miles " proposal unless base flight rate going to be 100 bucks.

On the return flight, flight attendant Britt went out of her way to inform passengers that several of us had tight connections.

Too many people are taking up space in the overhead bins with their extra piece of luggage. Since they cannot fit their backpacks or extra luggage piece under the seat in front of them, they store it in the overheads and thus taking up room for other passengers. It wasn’t only one or two persons; more like 12 or 13 passengers.

Kayak botched up the booking, i had to call delta and fix. In the process Delta failed to honor my comfort plus seat assignment that i had previously.

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

With Aeromexico it ended up good but with Delta it was bad because we did everything through Delta... Showed up at the Delta terminal... It was the wrong place! Nothing ever told us to go to the Aeromexico terminal. It said "in partnership with Aeromexico" but I was never instructed to check in with them or go to their terminal. We had to haul @$$ running through the airport and almost didn't make it thanks to this poor communication. 👎🏽

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Everything you need to know for your flight from Panama City to Mexico City Federal District

Information on your arrival and departure airports