$250 Find Cheap Flights from Panama City to Mexico

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Mexico departing on 3/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Panama City to Mexico

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Cancún
Cancún1 stop$460
Mexico City
Mexico City1 stop$574
Puerto Vallarta
Puerto Vallarta2 stops$657
Cancún
Cancún1 stop$460
Mexico City
Mexico City1 stop$574
Puerto Vallarta
Puerto Vallarta2 stops$657

Book Cheap Panama City to Mexico Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Mexico that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Mexico

Tue, Jul 21 - Tue, Aug 4
Delta Logo
6:00 am - 2:22 pm
ECP
-
CUN
8h 22m
1 stop
Delta Logo
8:00 am - 1:52 pm
CUN
-
ECP
5h 52m
1 stop
$460Delta
Tue, Jul 21 - Tue, Aug 4
Delta Logo
1:30 pm - 8:23 pm
ECP
-
CUN
6h 53m
1 stop
Delta Logo
8:00 am - 1:52 pm
CUN
-
ECP
5h 52m
1 stop
$470Delta
Tue, Jul 21 - Tue, Aug 4
Delta Logo
1:30 pm - 12:27 am
ECP
-
CUN
10h 57m
2 stops
Delta Logo
8:00 am - 1:52 pm
CUN
-
ECP
5h 52m
1 stop
$479Delta
Mon, Apr 20 - Fri, Apr 24
Aeromexico Logo
1:33 pm - 8:14 pm
ECP
-
CUN
6h 41m
1 stop
Aeromexico Logo
3:15 pm - 9:22 pm
CUN
-
ECP
6h 07m
1 stop
$480Aeromexico
Sat, May 9 - Thu, May 14
Delta Logo
1:50 pm - 8:03 pm
ECP
-
CUN
6h 13m
1 stop
Delta Logo
8:05 am - 7:09 pm
CUN
-
ECP
11h 04m
2 stops
$485Delta
Mon, Apr 13 - Fri, Apr 17
United Airlines Logo
6:30 am - 7:19 pm
ECP
-
CUN
12h 49m
1 stop
United Airlines Logo
7:51 am - 9:59 pm
CUN
-
ECP
14h 08m
1 stop
$487United Airlines
Tue, Mar 17 - Tue, Mar 24
American Airlines Logo
8:20 am - 3:10 pm
ECP
-
CUN
6h 50m
1 stop
American Airlines Logo
1:25 pm - 10:17 pm
CUN
-
ECP
8h 52m
1 stop
$488American Airlines
Mon, Apr 20 - Fri, Apr 24
Aeromexico Logo
7:05 am - 12:40 pm
ECP
-
CUN
5h 35m
1 stop
Aeromexico Logo
12:40 pm - 9:22 pm
CUN
-
ECP
8h 42m
1 stop
$490Aeromexico
Mon, Mar 9 - Tue, Mar 17
American Airlines Logo
7:19 am - 3:20 pm
ECP
-
CUN
8h 01m
2 stops
American Airlines Logo
7:45 am - 10:17 pm
CUN
-
ECP
14h 32m
2 stops
$492American Airlines
Tue, Mar 31 - Mon, Apr 6
United Airlines Logo
10:10 am - 5:50 pm
ECP
-
MEX
8h 40m
1 stop
United Airlines Logo
6:30 am - 9:59 pm
MEX
-
ECP
14h 29m
1 stop
$574United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to Mexico flights

Get data-powered insights and trends into flights from Panama City to Mexico to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to Mexico?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Mexico, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Mexico is August, when tickets cost $441 (return) on average. On the other hand, the most expensive months are March and May, when the average cost of round-trip tickets is $630 and $628 respectively.

Good to know

Low seasonJanuary
Cheapest flight$250
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 7% increase in price.
Flight from Panama City to Cancun

FAQs - booking Mexico flights

  • How does KAYAK find such low prices on flights from Panama City to Mexico?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Mexico.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Mexico?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to Mexico is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Mexico?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to Mexico with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Mexico?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to Mexico up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Panama City to Mexico

 
Need help choosing which airline to fly with from Panama City to Mexico? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8187 reviews
7.9Comfort
8.1Boarding
8.5Crew
7.8Entertainment
7.2Food
Airline reviews

The flight was great as well as the airline staff

10.0 ExcellentPatty, Feb 2026
TPA - ATL
Read more Delta reviews

The flight was great as well as the airline staff

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

I have diamond medallion status and usually we are in comfort plus . We were in main this time ( which was fine ) and my husband wanted wine . I have at least 10 vouchers for drinks that are good for this year and next! The attendant would not take the picture of the voucher as proof and never came back to check as She asked me to pull it up on delta Wi-Fi. Instead my husband just used his Amex to buy the wine . Disappointing!!!

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

The only thing nice I can say is the flight crew was really nice and apologetic about the situation. They shared as much information as they had and advised us on what we could do about missing connecting flights. The boarding process was so slow. The gate agent was working by herself and should have had someone working with her. It took almost an hour to board because she was trying to board a full flight of people and provide customer service to everyone who was flying standby and/or had questions. It was really chaotic. This didn't help the fact that we were delayed and folks were missing connections the longer it took.

The food is terrible. The staff is wonderful. Comfort is good.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Plane outlets in my row not working to charge phone. Staff response was, well it should be. Plug into seed for volume not working well. Had to find the sweet spot for plug in or it would shut off and on.

It was great with United overall except for two things. 1) It was a 5-hour flight and we were with kids, so we were asking for extra snacks. They were extremely reticent to dole them out even though there wasn't any meal and the kids were starting to hit their limit towards the end. 2) Baggage didn't arrive until 80 minutes after we landed.

Everything was absolutely wonderful from check in to baggage claim. Staff was very professional and sweet. Will definitely recommend United to family and friends.

Very turbulent trip made it pretty bearable, plus the lack of refreshments served and the lack of any air conditioning before takeoff which took an hour or more.

It was nice to have gotten up upgraded to first class with a meal on a three hour flight

They charged a fee for 1st bag checked. Others in same party were free.

Flight team stood out for perzonal attention, kindness at bright cheery attitudes at 8am. Very helpful.

Seats had less pitch than a regional jet. Food was OK. Have to buy alcohol on US based carriers flying international. Boarding was a mess. Did not have bags but overhead space was gone quick. Would like to see the airlines enforce the one bag over and one bag under policy

Great smooth flight. Had a seating change, but that was an improvement. Thanks United Airways Crew.

The worst landing I have ever had on a domestic flight. Thought we would lose the landing gear on landing in Newark. Then we spent 40 minutes trying to position the plane in the right place to be able to get the jet way to the plane. The plane arrived stopped. The announcer was that we were there. Everybody got up, then we were told to sit back down because they had to have us towed to a different position. We got towed and then everyone stood up and they told us we were in the wrong position to sit back down again, and then we got towed to a different position This did not happen immediately. It was 30 minutes while we wandered around a small section of the tarmac in Newark close to the gate, but apparently not close enough. Horrifying experience The CAB should be investigating that flight

From the check-in, to the flight, and arriving, everything went very smoothly. Unfortunately, when I received my baggage it was severely damaged. I have a hard shelled suitcase and it was completely smashed it. I’m not sure how this could happened but I am extremely disappointed that my belongings were damaged beyond repair and continued use.

Really nice, all good, nice crew and all on time

Unfortunately I had an awful boarding experience. Our first flight with Aeromexico was fine and landed on time however it couldn’t find a gate and we were late which made us lose our connecting flight with Aeromexico. The staff handled it horribly when we explained our situation and would not led us board when we missed the boarding time by a couple minutes. The staff were extremely rude and did not attempt to even help us. Because of this incident, my husband and I missed a full day of work which negatively impacted our salary which we need. Please compensate us for the work that we missed.

It was OK. The flight is pretty long for the airlines to only offer a simple sandwich on business class. The entertainment is similar to that on other Skyteam members. Ultimately the airline lost my bag and didn’t deliver it to me until the next day after a lengthy lost baggage report.

Aeroméxico cancelled my ticket without advice AND It make a last minute mess in my intinerary, no solving my situation, bad advice and bad customer service

The ground staff were not as friendly and nice to the passengers as the air crew. Flight attendants, cockpit crew were great and very nice to everyone on board.

My flight was delayed, then I got transferred to a new flight that was also delayed- which wasn’t Aeromexico’s fault, it was because of weather conditions. Most of the crew was very nice and patient, except for one or two flight attendants who were rude. The entertainment wasn’t on, so all the screens were off.

My wife's entertainment system did not work. Payed for flight upgrade but did not receive advertised "free WiFi".

Annoying that we had to go to departures and get boarding passes. Should allow us to be booked all the way through, this is the only airline i have this problem with in MEX. Late boarding and take off

Lousy No wheelchair. As normal at Atlanta Cheap airline Cheap aero plane. - Neither entertainment nor food on a 5 hour saga

Awful. Original flight was delayed 5 hours. Had to to take a connecting flight instead of direct. Had a 4 hour layover. I missed all of my morning meetings getting in 5 hours later than I was supposed to and had to change to take a later flight the next day to get them back in which cia time another $150.

On time on a day with lots of weather cancellations on other flights. Thank you for getting me home during a winter storm!

Don't change gate multiple times make people run across the airport. Announce delays in a timely manner. Have maintenance crew ready. Don't delay and keep passengers on the plane for 3 hrs. on tarmac.

The attendants were kind and helpful. A sugar-free drink would have been very welcome.

Little warm on the plane and delayed for an hour

UGH I HAD TO MISS MY FIRST FLIGHT TO TAMPA CAUSE OF THE 10 MINUTE DELAY OF THE ORLANDO TO MIAMI ONE SO THEY HAD ME GET ANOTHER TICKET. I AM NOT HAPPY AT ALL BECAUSE IT MADE ME MISS MY CONNECTING FLIGHT FROM TAMPA TO LONDON AND FORCED ME TO MISS A DAY AT MY ROOM IN THE UK.

Wish they didnt delay off-boarding for 10 minutes so i could connect to my flight from miami to tampa

It was fine. My connection in Charlotte to go to WPB was too late and I had to spend the night in the Charlotte Airport in the mini suites.

Boarding was organized and timely. Food was mediocre, especially for first class travel.

We were 4+ hours delayed. AA is absolutely obnoxious. They just kept pushing back the time to the point where we did not get into Vegas until after midnight when we were supposed to arrive like 845pm.

Everything you need to know for your flight from Panama City to Mexico

Information on your arrival and departure airports