$240 Find Cheap Flights from Panama City to Mexico - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Mexico departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Panama City to Mexico

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Cancún
Cancún1 stop$499
Mexico City
Mexico City1 stop$636
Puerto Vallarta
Puerto Vallarta1 stop$644
Cancún
Cancún1 stop$499
Mexico City
Mexico City1 stop$636
Puerto Vallarta
Puerto Vallarta1 stop$644

Book Cheap Panama City to Mexico Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Mexico that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Mexico

Sat, Dec 5 - Sat, Dec 12
Delta Logo
9:23 am - 9:10 pm
ECP
-
CUN
10h 47m
1 stop
Delta Logo
1:28 pm - 10:47 pm
CUN
-
ECP
10h 19m
2 stops
$499Delta
Wed, Oct 28 - Wed, Nov 4
Southwest Logo
6:10 am - 3:25 pm
ECP
-
CUN
9h 15m
2 stops
Southwest Logo
8:20 am - 3:35 pm
CUN
-
ECP
8h 15m
2 stops
$528Southwest
Wed, Oct 28 - Wed, Nov 4
United Airlines Logo
9:05 am - 2:24 pm
ECP
-
CUN
5h 19m
1 stop
United Airlines Logo
2:44 pm - 9:50 pm
CUN
-
ECP
8h 06m
1 stop
$549United Airlines
Wed, Oct 28 - Wed, Nov 4
American Airlines Logo
7:15 am - 1:34 pm
ECP
-
CUN
6h 19m
1 stop
American Airlines Logo
3:16 pm - 11:49 pm
CUN
-
ECP
9h 33m
2 stops
$559American Airlines
Thu, Jul 30 - Mon, Aug 3
Southwest Logo
7:50 am - 3:05 pm
ECP
-
CUN
7h 15m
1 stop
Southwest Logo
12:00 pm - 9:45 pm
CUN
-
ECP
9h 45m
2 stops
$571Southwest
Sat, Jul 25 - Fri, Jul 31
American Airlines Logo
6:54 pm - 9:34 am
ECP
-
CUN
14h 40m
1 stop
American Airlines Logo
8:00 am - 9:39 pm
CUN
-
ECP
13h 39m
1 stop
$585American Airlines
Sat, Dec 5 - Sat, Dec 12
American Airlines Logo
3:15 pm - 10:29 am
ECP
-
CUN
18h 14m
2 stops
American Airlines Logo
11:31 am - 9:16 pm
CUN
-
ECP
10h 45m
2 stops
$593American Airlines
Sat, Dec 5 - Sat, Dec 12
American Airlines Logo
3:15 pm - 10:29 am
ECP
-
CUN
18h 14m
2 stops
American Airlines Logo
11:31 am - 9:16 pm
CUN
-
ECP
10h 45m
2 stops
$594American Airlines
Wed, Oct 7 - Sun, Oct 11
American Airlines Logo
7:15 am - 3:22 pm
ECP
-
CUN
8h 07m
2 stops
American Airlines Logo
12:14 pm - 11:53 pm
CUN
-
ECP
11h 39m
1 stop
$604American Airlines
Sat, Aug 15 - Sat, Aug 22
United Airlines Logo
6:30 am - 3:40 pm
ECP
-
MEX
10h 10m
1 stop
United Airlines Logo
6:30 am - 1:46 pm
MEX
-
ECP
6h 16m
1 stop
$676United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to Mexico flights

Get data-powered insights and trends into flights from Panama City to Mexico to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to Mexico?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Mexico, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Mexico is August, when tickets cost $0 (return) on average. On the other hand, the most expensive months are March and May, when the average cost of round-trip tickets is $587 and $587 respectively.

Good to know

Low seasonDecember
Cheapest flight$240
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly and prices are also 17% lower on average.
Flight from Panama City to Cancun

FAQs - booking Mexico flights

  • How does KAYAK find such low prices on flights from Panama City to Mexico?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Mexico.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Mexico?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to Mexico is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Mexico?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to Mexico with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Mexico?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to Mexico up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Panama City to Mexico

 
Need help choosing which airline to fly with from Panama City to Mexico? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8454 reviews
8.1Boarding
7.2Food
7.8Comfort
7.8Entertainment
8.5Crew
Airline reviews

Five hour delays every hour, I wish it were all at once

2.0 MediocreAnonymous, Jun 2026
MCO - LGA
Read more Delta reviews

Five hour delays every hour, I wish it were all at once

Got rerouted from a straight flight from Orlando to Atlanta to Knoxville to a flight from Orlando to Detroit to Knoxville! Seriously!! Flight delay out of Detroit! Long day for what should have been a pretty easy travel day!

Left /arrived on time. Decent seat space. Like the wifi/plugs and entertainment. Windows and tray table were kinda gross. Attendants didn't start snack service til 40mins before landing. Two rows before us, captain came on to say there's turbulence and recalled staff to seats. So, no drink/snack. Later, attendants didn't stop to see if we had trash nor even look our way. Felt invisible! Almost all pilot announcements were not only unintelligible, but so quiet. We had no idea what she said.

Gate agent was unhelpful for handicapped boarding. Flight attendant seemed untrained.

Clean planes and not take my comfort class seat away.

Weather caused a long delay, but the efficiency and updates from the pilot were helpful. We were able to make our connection fortunately.

Planes were clean, no water or snacks on either flight.

Aside from a completely packed plane, I really have no complaints.

Much better than Latam, the worse airline company ever. I hope I don't have the need to fly Latam ever in my life again.

The flight was operated by Latam. The aircraft had a technical issue and the flight was delayed for the next day. They grounded other passengers to get their airplane assigned to my flight. Most of he ground staff don't speak English (Orlando Airport), but were very polite.The crew on the other hand could speak English and Portuguese. On board service was good.

Horrible I am at almost 2,000,000 miles on United. This was probably the worst flight ever. An hour and a half before takeoff I get a message that they’re changing the plane and I no longer have a seat in Polaris business Supposedly, there was a problem with the plane, but then there was no other plane Finally, they decided to bring a plane from Newark to Washington Dulles Of course the original flight was at 10:45 PM so by the time the plane got there it was 12:30 AM. It had not been cleaned. It had not been catered. They don’t really have people available to do those things when it’s not pre-programmed at 1 o’clock in the morning. The crew had to be changed And the new plane held 28 fewer people than the scheduled plane There is no way you can hate United Airlines enough The people at the gate were actually just fine, but it was management who was completely useless And did they send extra help to the people at the gate? Did they send supervisors? Of course not. Just don’t take United find somebody else or buy a boat

We used Kayak to reserve our tickets and specifically checked the luggage option which was a more expensive option. When we arrived at the terminal we had to pay an extra $90 per suitcase for the three passengers. This has been a pattern for the past 3 years. Why charge for a more expensive luggage option, and the ticket price not include luggage?

6 1/2 hours from Tampa to SFO on a Boeing 737. Cramped. No Service. No real food. One pass for coffee at the beginning and a second pass THREE hours later. And check-in in Tampa was nasty even by United standards. And I am at almost TWO million miles on United. It's a non-stop. But terrible service.

The flight had a delay but I made it to my connection. Flight was smooth overall

It's a short hop. My carryon was checked at the gate, I didn't have to drag it all over the airport. Excellent wheelchair assist.

Flights were on time actually early service was good and crew cheerful

The boarding process was straightforward. One pertinent observation regarding all boarding procedures is that if an individual requires assistance or possesses a special status and is part of preboarding, it is advisable to limit the number of passengers who can preboard with them, rather than the entire, sometimes large, companion groups. The seats are uncomfortable, and the entertainment options are significantly inferior compared to other airlines. During the snack service, I requested an additional bag of snacks, but my request was denied. Initially, the flight attendant agreed to my request.becoming a strange accurate moment. The flight duration was four hours.

Flights were on time. Free Wifi on plane. Everything was well organized.

Experience was great - no complaints. Took off on time, landed early. Got to the gate relatively quickly - took a little bit of extra time to deplane but nothing excessive.

Economy plus was so cramped I could not use my laptop. It was beyond bad.

I cancelled this flight 2 days before departure but I followed your texts and emails and IF you were correct this flight turned into a nightmare.

Absolutely terrible. They boarded the plane, supposedly realized they didn't refuel the plane or load the luggage so we sat as the gate inside the plane for over 2 hours while they supposedly did things that should have been done before having passengers board the planem

It was awful. The communication between corporate and the crew on the ground left more to be desired. The crew even said that Corporate was waiting on answers because they themselves didn't know. Every hour, there was a new excuse. I also understood that passengers were angry, but the crew should have done a better job at crowd control. There was a racial exchange between passengers that could've been avoided has the crew acted sooner.

We sat on plane at gate delayed without communication as to why we were just sitting there

Trash. Sat on the runway for 40 mins…missed connecting flight because of it now I’m stuck. Thanks…a whole fkn lot.

Little time between flight from Dallas to flight to Gainesville. We chose this one, 43 minutes between, because the price for a connection with at least an hour between, was so much higher. Had to ask passengers on the Dallas flight to please allow us to deplane ahead of them. The economy passengers allowed this. We had to walk very fast to the next gate, 35 gates away. Thankfully all in the same terminal. Getting to the small Gainesville plane was a little confusing as you enter an area that is boarding many small planes at the same time. We stood in the wrong line for about 15 seconds before realizing it was not our Gainesville flight. Since I had boarded at this gate in the past, I knew to check the signs carefully so we weren’t lost. The first class seat experience was wonderful. I really enjoyed the upgrade. We were offered an alcohol drink as soon as we sat down. I got something different but it was a great gesture especially since we really had to hurry to make the flight. We had packed expecting we might miss this connection, but made it. Our luggage didn’t miss the flight. American Airlines delivered our bags to our home the next day. That was very convenient!

Experience was good, however I had a delay due to weather happening and had to re purchase a seat on a new plane for a higher price (could be my own issue and misunderstanding) but other than that situation. First time flyer (by myself) was terrific!! The last from ORD to ALO didn't have wifi, but it was only 45 minutes so I'm sure that was part of the reason. Overall my experience was great! Next time I will remember to buy tickets with longer layovers. The delays really saved my overall anxiety. :)

No food/snack served during the flight. Crew wasn’t interested at all. Flew American First but flying low cost with Ryanair is even better

Ac was broken so we deplaned, waited 2 hours, taxiing for takeoff they said the plane would not fly so we went back to the gate and got a new plane which took another hour. In all a 4 hour delay for an 80 min flight.

Terrible, oxygen masks were deployed mid-flight. We returned to airport. Took additional 12 hours to get home.

Everything you need to know for your flight from Panama City to Mexico

Information on your arrival and departure airports