$255 Find Cheap Flights from Panama City to Mexico - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Mexico departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from Panama City to Mexico

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Cancún
Cancún1 stop$528
Mexico City
Mexico City1 stop$635
Puerto Vallarta
Puerto Vallarta1 stop$678
Cancún
Cancún1 stop$528
Mexico City
Mexico City1 stop$635
Puerto Vallarta
Puerto Vallarta1 stop$678

Book Cheap Panama City to Mexico Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Mexico that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Mexico

Sat, Jan 23 - Fri, Jan 29
Delta Logo
9:23 am - 4:30 pmECP  Panama City NW Florida Beaches-CUN Cancun
6h 07m1 stop Atlanta Hartsfield-Jackson
Delta Logo
11:00 am - 3:15 pmCUN  Cancun-ECP Panama City NW Florida Beaches
5h 15m1 stop Atlanta Hartsfield-Jackson
$528Delta
Sat, Jan 23 - Sat, Jan 30
Delta Logo
7:45 am - 2:00 pmECP  Panama City NW Florida Beaches-CUN Cancun
5h 15m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:10 pm - 10:47 pmCUN  Cancun-ECP Panama City NW Florida Beaches
8h 37m1 stop Atlanta Hartsfield-Jackson
$528Delta
Wed, Jan 20 - Tue, Feb 2
Delta Logo
9:23 am - 3:20 pmECP  Panama City NW Florida Beaches-CUN Cancun
4h 57m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:10 pm - 10:47 pmCUN  Cancun-ECP Panama City NW Florida Beaches
8h 37m1 stop Atlanta Hartsfield-Jackson
$528Delta
Mon, Sep 14 - Sat, Sep 19
Southwest Logo
6:00 am - 3:00 pmECP  Panama City NW Florida Beaches-CUN Cancun
9h 00m2 stops Dallas Love Field Houston Hobby
Southwest Logo
11:30 am - 6:10 pmCUN  Cancun-ECP Panama City NW Florida Beaches
6h 40m1 stop Lambert-St Louis
$537Southwest
Fri, Sep 18 - Fri, Sep 25
Southwest Logo
6:00 am - 3:00 pmECP  Panama City NW Florida Beaches-CUN Cancun
9h 00m2 stops Dallas Love Field Houston Hobby
Southwest Logo
11:35 am - 9:05 pmCUN  Cancun-ECP Panama City NW Florida Beaches
9h 30m2 stops Houston Hobby Dallas Love Field
$557Southwest
Mon, Sep 14 - Sat, Sep 19
Southwest Logo
5:10 am - 10:35 amECP  Panama City NW Florida Beaches-CUN Cancun
5h 25m1 stop Houston Hobby
Southwest Logo
11:30 am - 6:10 pmCUN  Cancun-ECP Panama City NW Florida Beaches
6h 40m1 stop Lambert-St Louis
$575Southwest
Thu, Sep 24 - Fri, Sep 25
United Airlines Logo
6:20 am - 12:33 pmECP  Panama City NW Florida Beaches-CUN Cancun
6h 13m1 stop Houston George Bush Intcntl
United Airlines Logo
1:12 pm - 10:18 pmCUN  Cancun-ECP Panama City NW Florida Beaches
9h 06m1 stop Houston George Bush Intcntl
$616United Airlines
Wed, Sep 2 - Wed, Sep 9
United Airlines Logo
6:30 am - 10:45 amECP  Panama City NW Florida Beaches-MEX Mexico City Benito Juarez
5h 15m1 stop Houston George Bush Intcntl
United Airlines Logo
6:30 am - 4:38 pmMEX  Mexico City Benito Juarez-ECP Panama City NW Florida Beaches
9h 08m1 stop Houston George Bush Intcntl
$635United Airlines
Fri, Oct 2 - Wed, Oct 7
American Airlines Logo
7:34 am - 8:45 pmECP  Panama City NW Florida Beaches-MEX Mexico City Benito Juarez
14h 11m1 stop Dallas/Fort Worth
American Airlines Logo
12:35 pm - 11:53 pmMEX  Mexico City Benito Juarez-ECP Panama City NW Florida Beaches
10h 18m1 stop Charlotte Douglas
$635American Airlines
Wed, Sep 2 - Wed, Sep 9
American Airlines Logo
6:40 am - 10:20 pmECP  Panama City NW Florida Beaches-MEX Mexico City Benito Juarez
16h 40m2 stops Charlotte Douglas Miami
American Airlines Logo
5:00 am - 2:22 pmMEX  Mexico City Benito Juarez-ECP Panama City NW Florida Beaches
8h 22m1 stop Dallas/Fort Worth
$640American Airlines
Booking Insights

KAYAK's insights & trends for Panama City to Mexico flights

Get data-powered insights and trends into flights from Panama City to Mexico to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to Mexico?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Mexico, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Mexico is September, when tickets cost $0 (return) on average. On the other hand, the most expensive months are June and August, when the average cost of round-trip tickets is $746 and $744 respectively.

Good to know

Low season

December

Cheapest flight

$255
Best time to beat the crowds with an average 3% drop in price.
Most popular time to fly and prices are also 22% lower on average.
Flight from Panama City to Cancun

FAQs - booking Mexico flights

  • How does KAYAK find such low prices on flights from Panama City to Mexico?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Mexico.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Mexico?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to Mexico is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Mexico?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to Mexico with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Mexico?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to Mexico up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Panama City to Mexico

 
Need help choosing which airline to fly with from Panama City to Mexico? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8499 reviews
7.8Comfort
8.5Crew
7.2Food
8.1Boarding
7.8Entertainment
Airline reviews

Boarding was quick and i made my connection early due to early arrival time

10.0 ExcellentKalen, Jul 2026
Read more Delta reviews

Boarding was quick and i made my connection early due to early arrival time

My flight was canceled, and instead of rebooking me on a non-stop first-class flight for the same day, which I originally had, Delta rebooked me on a one-stop flight for the following day. When I checked the Delta app, I noticed that there were available flights for both the same day and the next day. I believe this indicates poor management on their part.

My flight was delayed and I got back around 3.5 hours later than expected. I had to get a new connecting flight

I had only one problem. The temperature on the flight was too COLD. I froze throughout the flight. I thought it might be only my problem but when I went to the restroom during the flight, I saw several people huddling in their jackets. A couple had their winter coats on and I was jealous since I had only a very light jacket.

Five hour delays every hour, I wish it were all at once

Got rerouted from a straight flight from Orlando to Atlanta to Knoxville to a flight from Orlando to Detroit to Knoxville! Seriously!! Flight delay out of Detroit! Long day for what should have been a pretty easy travel day!

Left /arrived on time. Decent seat space. Like the wifi/plugs and entertainment. Windows and tray table were kinda gross. Attendants didn't start snack service til 40mins before landing. Two rows before us, captain came on to say there's turbulence and recalled staff to seats. So, no drink/snack. Later, attendants didn't stop to see if we had trash nor even look our way. Felt invisible! Almost all pilot announcements were not only unintelligible, but so quiet. We had no idea what she said.

Gate agent was unhelpful for handicapped boarding. Flight attendant seemed untrained.

Clean planes and not take my comfort class seat away.

Planes were clean, no water or snacks on either flight.

Wonderful flight! The crew was good, check-in was good and orderly and the flight was uneventful and good.

There was a piece of plastic baked into my buttermilk biscuit! I have a pictures. The flight attendants in first class were really apologetic, and tried to rectify the situation. I I am very appreciative that they were able to give me some packets of pretzels and gummy bears. I understand they don't personally handle the food until warming it up so I know it wasn't their fault. I don't know whether it was a newer aircraft, or different food packaging, but I was happy that when the food was being warmed up - it didn't smell like plastic. Jokes on me with finding plastic in my food.

Horrible experience. They delayed our flight 7 hours!! We had to seat at the airport with kids on 4th July all day!

Horrible I am at almost 2,000,000 miles on United. This was probably the worst flight ever. An hour and a half before takeoff I get a message that they’re changing the plane and I no longer have a seat in Polaris business Supposedly, there was a problem with the plane, but then there was no other plane Finally, they decided to bring a plane from Newark to Washington Dulles Of course the original flight was at 10:45 PM so by the time the plane got there it was 12:30 AM. It had not been cleaned. It had not been catered. They don’t really have people available to do those things when it’s not pre-programmed at 1 o’clock in the morning. The crew had to be changed And the new plane held 28 fewer people than the scheduled plane There is no way you can hate United Airlines enough The people at the gate were actually just fine, but it was management who was completely useless And did they send extra help to the people at the gate? Did they send supervisors? Of course not. Just don’t take United find somebody else or buy a boat

We used Kayak to reserve our tickets and specifically checked the luggage option which was a more expensive option. When we arrived at the terminal we had to pay an extra $90 per suitcase for the three passengers. This has been a pattern for the past 3 years. Why charge for a more expensive luggage option, and the ticket price not include luggage?

6 1/2 hours from Tampa to SFO on a Boeing 737. Cramped. No Service. No real food. One pass for coffee at the beginning and a second pass THREE hours later. And check-in in Tampa was nasty even by United standards. And I am at almost TWO million miles on United. It's a non-stop. But terrible service.

The flight had a delay but I made it to my connection. Flight was smooth overall

It's a short hop. My carryon was checked at the gate, I didn't have to drag it all over the airport. Excellent wheelchair assist.

Flights were on time actually early service was good and crew cheerful

The boarding process was straightforward. One pertinent observation regarding all boarding procedures is that if an individual requires assistance or possesses a special status and is part of preboarding, it is advisable to limit the number of passengers who can preboard with them, rather than the entire, sometimes large, companion groups. The seats are uncomfortable, and the entertainment options are significantly inferior compared to other airlines. During the snack service, I requested an additional bag of snacks, but my request was denied. Initially, the flight attendant agreed to my request.becoming a strange accurate moment. The flight duration was four hours.

My flight was delayed several hours, which is to be expected (American never fails to disappoint me!), but the parts that really bothered me are as follows: 1) I was unable to add myself to the standby list for another flight in the app, nor could the gate agents figure out how to help me do so (the app is difficult to work with and simply did not allow me to perform the action of adding myself to the list) 2) When I asked the gate agents to add me to the standby list, the agent said that he had added me, but I was not able to confirm that I was on the list in the app; as it turns out, I had NOT been added to the list after all. He had lied to me and/or failed to add me to the list. 3) I figured out I had not been added to the standby list when I spoke to the (rather rude, snippy, and dismissive) other gate agent, who finally did add me to the list after giving me some pretty unnecessary attitude. I understand that gate agents experience the worst of stressed travelers every day, so I appreciate that I was eventually able to make it onto the standby flight with their help. However, the app needs some SERIOUS attention!

Nice ! I am gold member at United Airlnes probably I will shift at American Airlines and JAL ! Thank you ! Kindly maintain quality service I fly often! ❤️

The flight was delayed 4 hours, and when we finally boarded, they told us that the fuel was only just then checked. So, we waited even longer to take off.

Everything was done like clockwork and I find no fault with the airline.

Like all planes recently, entertainment is achieved by giving the patron free WiFi and letting them stream shows via the screen on a phone or tablet.

I thought American Airlines did well considering the adverse weather situation over July 21 and 22. I especially appreciated the consideration given to me when I got stuck in Miami on my way to Boston from Charleston, West Virginia. Thank you for providing a voucher for an overnight stay. Though it was only a few hours of sleep, it was very helpful. I was able to reschedule my medical appointment and got back to the Boston area on the 1st flight out of Miami as a standby passenger. It was very helpful that I was given number one priority on the standby list.

Experience was good, however I had a delay due to weather happening and had to re purchase a seat on a new plane for a higher price (could be my own issue and misunderstanding) but other than that situation. First time flyer (by myself) was terrific!! The last from ORD to ALO didn't have wifi, but it was only 45 minutes so I'm sure that was part of the reason. Overall my experience was great! Next time I will remember to buy tickets with longer layovers. The delays really saved my overall anxiety. :)

No food/snack served during the flight. Crew wasn’t interested at all. Flew American First but flying low cost with Ryanair is even better

Ac was broken so we deplaned, waited 2 hours, taxiing for takeoff they said the plane would not fly so we went back to the gate and got a new plane which took another hour. In all a 4 hour delay for an 80 min flight.

Terrible, oxygen masks were deployed mid-flight. We returned to airport. Took additional 12 hours to get home.

Everything you need to know for your flight from Panama City to Mexico

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