$281 Find Cheap Flights from Panama City to Mexico - Compare and Save

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Cheap Flights from Panama City to Mexico

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Cancún
Cancún1 stop$615
Puerto Vallarta
Puerto Vallarta1 stop$760
Cancún
Cancún1 stop$615
Puerto Vallarta
Puerto Vallarta1 stop$760
Booking Insights

Price, demand and travel trends for Panama City to Mexico flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Are flights from Panama City to Mexico cheaper or more expensive than last year?

Fares from Panama City to Mexico are running about 6% higher than they were around this time last year, averaging $636 round-trip.

What are the cheapest fares from Panama City to Mexico right now?

Here are the cheapest round-trip fares from Panama City to Mexico on KAYAK in the last week:

• Cancun (CUN) from $610
• Mexico City Benito Juarez (MEX) from $614
• Santiago de Querétaro (QRO) from $684
• Cozumel Intl (CZM) from $689
• San José del Cabo Los Cabos (SJD) from $695

What’s the cheapest month to fly from Panama City to Mexico?

January is the cheapest time of year to fly, with average fares of $553. Prices are highest in October, when average flight costs increase to around $786.

Which airport in Mexico is the cheapest to fly to from Panama City?

Based on KAYAK data from the past 12 months, the cheapest airports to fly into Mexico are:

• San Luis Potosi (SLP) from $489
• Cancun (CUN) from $538
• Guadalajara Miguel Hidal (GDL) from $578

What’s the cheapest day to fly from Panama City to Mexico?

Tuesday tends to be the cheapest day to fly from Panama City to Mexico, while Friday is the most expensive. Fares run about 21% higher that day, based on the past 12 months of KAYAK data.

What's the cheapest time of day to fly from Panama City to Mexico?

Data from the past 12 months shows it's cheapest to fly to Mexico during the morning with average prices of $676. The evening is the most expensive time to fly, with average prices of $761.

Key details for Panama City to Mexico flights

Low season

October

Cheapest flight

$281
Beat the crowds with an average 44% drop in travelers.
The most popular month to fly with an average 62% increase in travelers.
One-way flight from Panama City to Cancún

Your Panama City to Mexico flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Panama City to Mexico?

    Fares from Panama City to Mexico are around their usual level right now. A round-trip under $578 is considered a good deal, so it's worth keeping an eye out, or setting a Price Alert to catch price changes.

  • How much should I budget for a flight from Panama City to Mexico?

    Over the past 12 months, round-trip fares from Panama City to Mexico have ranged from $578 to $807.

  • What are the main airports serving Mexico?

    Mexico has 62 airports. The three busiest are Cancun (CUN) (17% of arrivals), Puerto Vallarta Ordaz (PVR) (17%) and Guadalajara Miguel Hidal (GDL) (14%).

  • What airlines fly nonstop from Panama City to Mexico?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Panama City to Mexico. One-stop options include Delta and Southwest.

  • Which cabin classes are available on flights from Panama City to Mexico?

    On flights from Panama City to Mexico you can book Economy Class, Premium Economy Class or First Class.

  • What are some popular landmarks in Mexico?

    KAYAK travelers' favorite landmarks in Mexico include:

    • El Ángel de la Independencia
    • Plaza de la Constitucion
    • Mexico City Stadium
    • Estadio GNP Seguros

Your guide to booking Panama City to Mexico flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your travel dates are flexible, book your trip for January when flights are typically cheapest and avoid October when prices are at their highest.
  • Flying on Tuesday is usually the cheapest. Flights on Friday cost about 21% more on average, so being flexible with your travel dates could help you save.
  • If you're looking to save, San Luis Potosi (SLP) is the cheapest airport to fly into from Panama City. If you have onward travel, don't forget to factor in the cost of your journey by train, bus or domestic flight.
  • Start your trip in Cancún, which is the most popular destination in Mexico. From there, it's easy to continue on to other popular destinations such as Playa del Carmen, Cabo San Lucas and Puerto Vallarta.

Reviews of the top airlines flying from Panama City to Mexico

 
Need help choosing which airline to fly with from Panama City to Mexico? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8652 reviews
7.8Comfort
8.1Boarding
8.5Crew
7.8Entertainment
7.2Food
Airline reviews

Great flight. Thank you for the upgrade to first class.

10.0 ExcellentLisa, Oct 2026
Read more Delta reviews

Great flight. Thank you for the upgrade to first class.

Everything was great. The only thing that wasn’t was the breakfast calzone which was basically warm bread. It was very tasteless and wasn’t good at all

I usually like delta. However this is my second flight that the wifi does not work

Both legs on the way were smaller planes, each had a mechanical issue causing a delay

Delayed flight. Dirty seats, dirty seat belts with food stuck on it from previous passengers maybe. No one cleaned the seats or flight.

No headphones, forced to sit in another seat that I did not book, had to check my carry on when I boarded the plane I saw backpacks and other non carry on items stuffed in the carry on holder! Horrible experience Wi-Fi did not work either

There was no food, so :( to that one. The flight was delayed by 3 hours. Not Delta's fault. Not the crew's fault. Considering how tired all us passengers were, everything went surprisingly well. The flight crew were very helpful, friendly, and professional. I always fly Delta.

Terrible. Waited on runway for 1+ hour after landing and then was brought to wrong terminal

Pushing back flight and ultimately cancelling it after multiple changes and hours of delays. Comm were terrible as to what was going on and what options were available.

Planes were clean, no water or snacks on either flight.

Fantastic experience once again flying with United! There was great communication from the cockpit and one of the flight attendants went out of her way to get my two little kids some special treats which elevated our travel experience coming home.

Flight attendants need to know their plane. Seated in first row yesterday. The seat had about a 1 inch recline that was not adjustable. I don't appreciate being awakened to raise a seat that can't go any further forward and such a small recline is either irrelevant or the plane needs to be repaired. Not the way to treat any customer and especially the ones who have paid that level of money for the seats.

Flights was great, service and transit support was outstanding - but the food was limited and of poor quality - only a snack on the first hour for 2 hours 1/2 leg. and a light breakfast on the second 4 hour leg.

typical but they have finally enhanced the wifi on some UA flights. Boy, its such a huge improvement

Return flight was perfect. All on time and no hiccups. However, going was another story. I don't blame United for the weather, but I am rather disappointed in its response to my getting stranded in my layover city for the night. United gave me a $20 food voucher. That's it. But besides this policy, the employees were incredibly helpful rerouting me to my final destination in Fort Lauderdale, FL. So overall, 8 out of 10. 10 out of 10 for flight comfort, inflight service and before flight service. 5 out of 10 for layover handling.

The price. Omg $1100. Was crazy and it was not clear on the website.

Delayed too much. 1.5 hrs in the airport and another 1 hr in the runway. Got too late in the night. There was no proper food available.

Did not like the check in guy quibbling over a couple pounds at the luggage weigh in

This is related to my second leg of the flight, from Washington DC to SFO. I understand things happen, but I got home at 3 am for a 12:59 am landing. I live 10 min from the airport. Bridge breaks when a few rows of the plane are off? Maintenance didn’t catch that?

WiFi was slow as compared to trip down. Maybe because it was a night flight and more people were using it?

More options for your flight from Panama City to Mexico

Complete your trip to Mexico with a hotel stay or car rental