$250 Find Cheap Flights from Panama City to Mexico - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to Mexico departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Cheap Flights from Panama City to Mexico

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Cancún
Cancún2 stops$519
Mexico City
Mexico City1 stop$636
Puerto Vallarta
Puerto Vallarta2 stops$654
Oaxaca
Oaxaca1 stop$758
Cancún
Cancún2 stops$519
Mexico City
Mexico City1 stop$636
Puerto Vallarta
Puerto Vallarta2 stops$654
Oaxaca
Oaxaca1 stop$758

Book Cheap Panama City to Mexico Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to Mexico that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to Mexico

Fri, Aug 28 - Fri, Sep 4
Delta Logo
6:00 am - 6:44 pm
ECP
-
CUN
12h 44m
2 stops
Delta Logo
2:10 pm - 11:30 pm
CUN
-
ECP
9h 20m
1 stop
$519Delta
Mon, Nov 2 - Fri, Nov 6
Southwest Logo
7:00 am - 7:45 pm
ECP
-
CUN
11h 45m
2 stops
Southwest Logo
8:20 am - 9:45 pm
CUN
-
ECP
14h 25m
2 stops
$521Southwest
Mon, Nov 2 - Fri, Nov 6
United Airlines Logo
9:05 am - 3:37 pm
ECP
-
CUN
5h 32m
1 stop
United Airlines Logo
4:47 pm - 9:50 pm
CUN
-
ECP
6h 03m
1 stop
$530United Airlines
Mon, Nov 2 - Fri, Nov 6
Southwest Logo
10:10 am - 7:45 pm
ECP
-
CUN
8h 35m
2 stops
Southwest Logo
8:20 am - 4:40 pm
CUN
-
ECP
9h 20m
1 stop
$534Southwest
Mon, Aug 10 - Tue, Aug 18
United Airlines Logo
9:00 am - 2:37 pm
ECP
-
CUN
5h 37m
1 stop
United Airlines Logo
7:51 am - 1:52 pm
CUN
-
ECP
6h 01m
1 stop
$543United Airlines
Sun, Aug 2 - Thu, Aug 13
Delta Logo
9:12 am - 2:36 pm
ECP
-
CUN
5h 24m
1 stop
Delta Logo
12:30 pm - 11:30 pm
CUN
-
ECP
11h 00m
1 stop
$570Delta
Sat, Oct 17 - Sat, Oct 24
American Airlines Logo
6:43 pm - 11:14 am
ECP
-
CUN
16h 31m
1 stop
American Airlines Logo
3:31 pm - 11:53 pm
CUN
-
ECP
8h 22m
1 stop
$599American Airlines
Sat, Dec 5 - Sat, Dec 12
American Airlines Logo
3:15 pm - 10:29 am
ECP
-
CUN
18h 14m
2 stops
American Airlines Logo
3:10 pm - 11:55 pm
CUN
-
ECP
9h 45m
2 stops
$603American Airlines
Mon, Aug 10 - Fri, Aug 14
American Airlines Logo
5:48 pm - 11:25 am
ECP
-
CUN
17h 37m
2 stops
American Airlines Logo
11:31 am - 10:40 pm
CUN
-
ECP
11h 09m
2 stops
$609American Airlines
Wed, Aug 5 - Sat, Aug 15
Delta Logo
7:35 am - 2:22 pm
ECP
-
CUN
6h 47m
1 stop
Delta Logo
8:05 am - 9:40 pm
CUN
-
ECP
13h 35m
1 stop
$610Delta
Booking Insights

KAYAK's insights & trends for Panama City to Mexico flights

Get data-powered insights and trends into flights from Panama City to Mexico to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to Mexico?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to Mexico, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to Mexico is August, when tickets cost $0 (return) on average. On the other hand, the most expensive months are June and May, when the average cost of round-trip tickets is $746 and $708 respectively.

Good to know

Low season

December

Cheapest flight

$250
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly and prices are also 17% lower on average.
Flight from Panama City to Cancun

FAQs - booking Mexico flights

  • How does KAYAK find such low prices on flights from Panama City to Mexico?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to Mexico.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to Mexico?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to Mexico is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to Mexico?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to Mexico with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to Mexico?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to Mexico up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Panama City to Mexico

 
Need help choosing which airline to fly with from Panama City to Mexico? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8476 reviews
8.1Boarding
7.8Comfort
7.8Entertainment
7.2Food
8.5Crew
Airline reviews

My flight was delayed and I got back around 3.5 hours later than expected. I had to get a new connecting flight

2.0 MediocreAnonymous, Jul 2026
MCO - ATL
Read more Delta reviews

My flight was delayed and I got back around 3.5 hours later than expected. I had to get a new connecting flight

I had only one problem. The temperature on the flight was too COLD. I froze throughout the flight. I thought it might be only my problem but when I went to the restroom during the flight, I saw several people huddling in their jackets. A couple had their winter coats on and I was jealous since I had only a very light jacket.

Five hour delays every hour, I wish it were all at once

Got rerouted from a straight flight from Orlando to Atlanta to Knoxville to a flight from Orlando to Detroit to Knoxville! Seriously!! Flight delay out of Detroit! Long day for what should have been a pretty easy travel day!

Left /arrived on time. Decent seat space. Like the wifi/plugs and entertainment. Windows and tray table were kinda gross. Attendants didn't start snack service til 40mins before landing. Two rows before us, captain came on to say there's turbulence and recalled staff to seats. So, no drink/snack. Later, attendants didn't stop to see if we had trash nor even look our way. Felt invisible! Almost all pilot announcements were not only unintelligible, but so quiet. We had no idea what she said.

Gate agent was unhelpful for handicapped boarding. Flight attendant seemed untrained.

Clean planes and not take my comfort class seat away.

Weather caused a long delay, but the efficiency and updates from the pilot were helpful. We were able to make our connection fortunately.

Planes were clean, no water or snacks on either flight.

Aside from a completely packed plane, I really have no complaints.

There was a piece of plastic baked into my buttermilk biscuit! I have a pictures. The flight attendants in first class were really apologetic, and tried to rectify the situation. I I am very appreciative that they were able to give me some packets of pretzels and gummy bears. I understand they don't personally handle the food until warming it up so I know it wasn't their fault. I don't know whether it was a newer aircraft, or different food packaging, but I was happy that when the food was being warmed up - it didn't smell like plastic. Jokes on me with finding plastic in my food.

Horrible experience. They delayed our flight 7 hours!! We had to seat at the airport with kids on 4th July all day!

Horrible I am at almost 2,000,000 miles on United. This was probably the worst flight ever. An hour and a half before takeoff I get a message that they’re changing the plane and I no longer have a seat in Polaris business Supposedly, there was a problem with the plane, but then there was no other plane Finally, they decided to bring a plane from Newark to Washington Dulles Of course the original flight was at 10:45 PM so by the time the plane got there it was 12:30 AM. It had not been cleaned. It had not been catered. They don’t really have people available to do those things when it’s not pre-programmed at 1 o’clock in the morning. The crew had to be changed And the new plane held 28 fewer people than the scheduled plane There is no way you can hate United Airlines enough The people at the gate were actually just fine, but it was management who was completely useless And did they send extra help to the people at the gate? Did they send supervisors? Of course not. Just don’t take United find somebody else or buy a boat

We used Kayak to reserve our tickets and specifically checked the luggage option which was a more expensive option. When we arrived at the terminal we had to pay an extra $90 per suitcase for the three passengers. This has been a pattern for the past 3 years. Why charge for a more expensive luggage option, and the ticket price not include luggage?

6 1/2 hours from Tampa to SFO on a Boeing 737. Cramped. No Service. No real food. One pass for coffee at the beginning and a second pass THREE hours later. And check-in in Tampa was nasty even by United standards. And I am at almost TWO million miles on United. It's a non-stop. But terrible service.

The flight had a delay but I made it to my connection. Flight was smooth overall

It's a short hop. My carryon was checked at the gate, I didn't have to drag it all over the airport. Excellent wheelchair assist.

Flights were on time actually early service was good and crew cheerful

The boarding process was straightforward. One pertinent observation regarding all boarding procedures is that if an individual requires assistance or possesses a special status and is part of preboarding, it is advisable to limit the number of passengers who can preboard with them, rather than the entire, sometimes large, companion groups. The seats are uncomfortable, and the entertainment options are significantly inferior compared to other airlines. During the snack service, I requested an additional bag of snacks, but my request was denied. Initially, the flight attendant agreed to my request.becoming a strange accurate moment. The flight duration was four hours.

Flights were on time. Free Wifi on plane. Everything was well organized.

Not great. I understand delays happen due to weather and crew issues, but it was unacceptable that no agents were available at the counters inside the airport for customer service or help getting on a standby list. The app was not helpful either. I stood in line for an hour waiting for someone to show up at the gate to help me get on a standby flight. Customer care does not seem to be a priority.

As I said I never took the flight back from due to earlier delayed that prevented from taking the second trip back and nobody helped me to rebook from kayak

It was awful. My first flight was delayed and as a consequence I lost my second flight to Greensboro. I did not know what to do so I rebook myself a flight to Charlotte . It was very inconvenient I not to have anybody form corporate assisting me either from PwC or from kayak . It is a very disappointing experience that American did not wait 1 minute or told me to rebook before making the first flight

Would have been good to have the live TV outside of the continental United States as AA was promoting they are sponsors of the Fifa World Cup only for the live coverage to end.

Terrible check in experience in Miami airport by a so-called supervisor. Food came and they were picking up trash within 5 mins. Did not get fed again for about 6 hours. No chance to buy anything on board, horrible experience. Flight attendants have no control over passengers dropping off bags closer to the exit, not close to their seat.

American Airlines changed are gate no fewer than four times. Walking back and forth from one concourse to another was exhausting, especially after all the flight delays.

Experience was good, however I had a delay due to weather happening and had to re purchase a seat on a new plane for a higher price (could be my own issue and misunderstanding) but other than that situation. First time flyer (by myself) was terrific!! The last from ORD to ALO didn't have wifi, but it was only 45 minutes so I'm sure that was part of the reason. Overall my experience was great! Next time I will remember to buy tickets with longer layovers. The delays really saved my overall anxiety. :)

No food/snack served during the flight. Crew wasn’t interested at all. Flew American First but flying low cost with Ryanair is even better

Ac was broken so we deplaned, waited 2 hours, taxiing for takeoff they said the plane would not fly so we went back to the gate and got a new plane which took another hour. In all a 4 hour delay for an 80 min flight.

Terrible, oxygen masks were deployed mid-flight. We returned to airport. Took additional 12 hours to get home.

Everything you need to know for your flight from Panama City to Mexico

Information on your arrival and departure airports