$307 Find Cheap Flights from Panama City to Mexico - Compare and Save

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Cheap Flights from Panama City to Mexico

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Cancún
Cancún1 stop$625
Puerto Vallarta
Puerto Vallarta2 stops$760
Oaxaca
Oaxaca2 stops$535
San Luis Potosí
San Luis Potosí2 stops$897
Cancún
Cancún1 stop$625
Puerto Vallarta
Puerto Vallarta2 stops$760
Oaxaca
Oaxaca2 stops$535
San Luis Potosí
San Luis Potosí2 stops$897
Booking Insights

Price, demand and travel trends for Panama City to Mexico flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Are flights from Panama City to Mexico cheaper or more expensive than last year?

Fares from Panama City to Mexico are running about 6% higher than they were around this time last year, averaging $636 round-trip.

What are the cheapest fares from Panama City to Mexico right now?

Here are the cheapest round-trip fares from Panama City to Mexico on KAYAK in the last week:

• Cancun (CUN) from $625
• Tulum Intl (TQO) from $650
• Santiago de Querétaro (QRO) from $720
• Mexico City Benito Juarez (MEX) from $728
• Cozumel Intl (CZM) from $759

What’s the cheapest month to fly from Panama City to Mexico?

January is the cheapest time of year to fly, with average fares of $553. Prices are highest in October, when average flight costs increase to around $936.

Which airport in Mexico is the cheapest to fly to from Panama City?

Based on KAYAK data from the past 12 months, the cheapest airports to fly into Mexico are:

• Tulum Intl (TQO) (avg. price $587)
• Cancun (CUN) (avg. price $587)
• Mexico City Benito Juarez (MEX) (avg. price $612)

What’s the cheapest day to fly from Panama City to Mexico?

Tuesday tends to be the cheapest day to fly from Panama City to Mexico, while Friday is the most expensive. Fares run about 26% higher that day, based on the past 12 months of KAYAK data.

What's the cheapest time of day to fly from Panama City to Mexico?

Data from the past 12 months shows it's cheapest to fly to Mexico during the afternoon with average prices of $665. The evening is the most expensive time to fly, with average prices of $761.

Key details for Panama City to Mexico flights

Low season

September

Cheapest flight

$307
Beat the crowds with an average 37% drop in travelers.
The most popular month to fly with an average 44% increase in travelers.
One-way flight from Panama City to Cancún

Your Panama City to Mexico flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Panama City to Mexico?

    Fares from Panama City to Mexico are around their usual level right now. A round-trip under $587 is considered a good deal, so it's worth keeping an eye out, or setting a Price Alert to catch price changes.

  • How much should I budget for a flight from Panama City to Mexico?

    Over the past 12 months, round-trip fares from Panama City to Mexico have ranged from $587 to $802.

  • What are the main airports serving Mexico?

    Mexico has 62 airports. The three busiest are Cancun (CUN) (24% of arrivals), Guadalajara Miguel Hidal (GDL) (14%) and Mexico City Benito Juarez (MEX) (12%).

  • What airlines fly nonstop from Panama City to Mexico?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Panama City to Mexico. One-stop options include Delta and Southwest.

  • Which cabin classes are available on flights from Panama City to Mexico?

    On flights from Panama City to Mexico you can book Economy Class or First Class.

  • What are some popular landmarks in Mexico?

    KAYAK travelers' favorite landmarks in Mexico include:

    • El Ángel de la Independencia
    • Plaza de la Constitucion
    • Centro Cultural Tijuana
    • Mexico City Stadium

Your guide to booking Panama City to Mexico flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your travel dates are flexible, book your trip for January when flights are typically cheapest and avoid October when prices are at their highest.
  • Flying on Tuesday is usually the cheapest. Flights on Friday cost about 26% more on average, so being flexible with your travel dates could help you save.
  • If you're looking to save, Tulum Intl (TQO) is the cheapest airport to fly into from Panama City. If you have onward travel, don't forget to factor in the cost of your journey by train, bus or domestic flight.
  • Start your trip in Cancún, which is the most popular destination in Mexico. From there, it's easy to continue on to other popular destinations such as Playa del Carmen, Cabo San Lucas and Puerto Vallarta.

Reviews of the top airlines flying from Panama City to Mexico

 
Need help choosing which airline to fly with from Panama City to Mexico? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8700 reviews
7.2Food
7.8Entertainment
8.5Crew
7.8Comfort
8.1Boarding
Airline reviews

Delta always provides stellar service. I am always impressed and will try my best to travel via Delta if I can afford it.

10.0 ExcellentCharlean, Oct 2026
Read more Delta reviews

Delta always provides stellar service. I am always impressed and will try my best to travel via Delta if I can afford it.

I think in the future I cannot fly anything less than Comfort plus. The seats vary depending on the plane. The people are extremely nice and funny. I try to only fly Delta if I can help it.

Great flight. Thank you for the upgrade to first class.

Everything was great. The only thing that wasn’t was the breakfast calzone which was basically warm bread. It was very tasteless and wasn’t good at all

I usually like delta. However this is my second flight that the wifi does not work

Both legs on the way were smaller planes, each had a mechanical issue causing a delay

Delayed flight. Dirty seats, dirty seat belts with food stuck on it from previous passengers maybe. No one cleaned the seats or flight.

No headphones, forced to sit in another seat that I did not book, had to check my carry on when I boarded the plane I saw backpacks and other non carry on items stuffed in the carry on holder! Horrible experience Wi-Fi did not work either

There was no food, so :( to that one. The flight was delayed by 3 hours. Not Delta's fault. Not the crew's fault. Considering how tired all us passengers were, everything went surprisingly well. The flight crew were very helpful, friendly, and professional. I always fly Delta.

Planes were clean, no water or snacks on either flight.

Starlink internet made the flight time shrink and I was able to work.

We sat on the tarmac in Denver for over 30 minutes because a plane was in our gate. The pilot kept saying it will just be 5 minutes or less. However, we sat for over 30 minutes. Experiences like this make customers not trust what the pilot is saying.

Loved the easy process to board and the experience overall was smooth

Service was slow Flight was very loud at back of plane

Fine except from Chicago to moline three different gate changes and flight times

The food could have been better and the entertainment could have better movies or streaming.

Fantastic experience once again flying with United! There was great communication from the cockpit and one of the flight attendants went out of her way to get my two little kids some special treats which elevated our travel experience coming home.

Flight attendants need to know their plane. Seated in first row yesterday. The seat had about a 1 inch recline that was not adjustable. I don't appreciate being awakened to raise a seat that can't go any further forward and such a small recline is either irrelevant or the plane needs to be repaired. Not the way to treat any customer and especially the ones who have paid that level of money for the seats.

Flights was great, service and transit support was outstanding - but the food was limited and of poor quality - only a snack on the first hour for 2 hours 1/2 leg. and a light breakfast on the second 4 hour leg.

typical but they have finally enhanced the wifi on some UA flights. Boy, its such a huge improvement

More options for your flight from Panama City to Mexico

Complete your trip to Mexico with a hotel stay or car rental