$323 Find Cheap Flights from Panama City to Santiago - Compare and Save

These are the earliest and latest flight times available from Panama City to Santiago:

• Earliest: departs at 11:48 am and lands at 6:17 pm
• Latest: departs at 9:39 pm and lands at 4:08 am.

The flight takes about 6h 29m.

Only Economy Class is available on flights from Panama City to Santiago.

A nonstop flight from Panama City to Santiago takes 6h 29m, covering 2,986 miles.

Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

Round-trip flights from Panama City to Santiago range from $561 to $682, with an average of $618 over the past 12 months. Anything below $561 counts as a good deal.

Last-minute fares on this route (booked within two weeks of departure) run 5% above the $618 route average. Book 10 weeks before departure for the lowest fares.

On this route, nonstop and layover fares are close on average, with nonstop at $631 round-trip and layover options via Bogotá El Dorado (BOG) at $623.

Copa Airlines is the only airline operating Panama City to Santiago flights. 90% of its flights are on time.

There is no standard. Checked-bag policies vary by airline on this route. Most carriers charge $85–$100 for the first checked bag in economy. Premium fares and elite-status bookings typically include a free checked bag.

The Boeing 737 MAX 9 family is used most often on this route, operated mainly by Copa Airlines. Other aircraft seen on the route include Boeing 737 MAX 8 variants.

Afternoon is the busiest departure period on Panama City to Santiago flights, with 34% of flights leaving in that window. Evening departures account for 33%, morning flights for 17%, and night flights for 16%.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $598 to $3,124. That means the highest observed fare was about 5x higher than the lowest one.

One-way fares from Panama City to Santiago are currently higher than usual. Average one-way flight prices are about $585, which is 60% above the typical average for this route.

Santiago Arturo Merino Benitez Airport (SCL) hosts 5 major car rental companies, with daily rates starting from around $6 for economy cars. Top options include:

• Lucano
• United Rent-A-Car
• Rosselot
• FlexWays
• Alamo

Flights from Panama City to Santiago usually depart from Panama City Tocumen Intl (PTY) and arrive at Santiago Arturo Merino Benitez (SCL).

Night flights have the fewest delays on this route, while afternoon departures tend to have the most.

A flight is considered delayed when it departs 15 minutes or more after its scheduled time. This is the standard used by the US Department of Transportation and most airline industry reporting. On the Panama City to Santiago route, 10% of flights were delayed in the past 3 months, with delays averaging 1h 56m.

One-stop flights from Panama City to Santiago most commonly connect through:

• Bogotá El Dorado (BOG) - 100% of one-stop connections
• Lima J Chavez Intl (LIM) - 0% of one-stop connections
• Miami (MIA) - 0% of one-stop connections

Yes. Flexible dates can save you up to 7% on flights from Panama City to Santiago. Tuesday is the cheapest departure day at $602 round-trip on average, while Thursday is the most expensive at $645, a difference of $43.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Only Copa Airlines operates flights between Panama City and Santiago.

Flying via Bogotá El Dorado (BOG) gives the shortest average 1-stop total travel time at 9h 51m, compared with 13h 01m via Lima J Chavez Intl (LIM) and 17h 12m via Miami (MIA).

Santiago is 2 hours ahead of Panama City (Chile Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

Some of the most popular sights in Santiago are Estadio Nacional Julio Martinez Pradanos, Costanera Center and Espacio Riesco Convention and Exhibition Center. These are among the most viewed places in Santiago on KAYAK.

Among airlines operating Panama City to Santiago flights:

• Copa Airlines: offers extra legroom; offers free seat selection

Extra legroom and free seat selection availability depends on fare class and route.

Here are some options for this route, based on selected ticket types and cabin classes:

• Copa Airlines: a cabin bag and a checked bag in Economy Class

Bag allowance can vary by ticket type, cabin class, route and airline, so always check the fare details before booking.