$311 Find Cheap Flights from Panama to St. Louis

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to St. Louis departing on 4/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to St. Louis

 
These are the airlines KAYAK users have selected most often from within our search results for flights to St. Louis, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results for flights to St. Louis, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$538
Overall average: $546
United Airlines
Thu 4/30Mon 5/4
PTY - STL • 2 stops
Cheapest one-way
$311
Typical prices: $329-$403
Multiple Airlines
Wed 4/1
PTY - STL • 3 stops
When to travel
June
Cheapest • 35% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to St. Louis!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Panama to St. Louis

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama to St. Louis that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama to St. Louis

Thu, Apr 30 - Mon, May 4
United Airlines Logo
3:30 pm - 8:18 am
PTY
-
STL
16h 48m
2 stops
United Airlines Logo
6:49 pm - 2:14 pm
STL
-
PTY
19h 25m
2 stops
$538United Airlines
Fri, May 1 - Tue, May 5
Delta Logo
2:27 pm - 11:34 pm
PTY
-
STL
9h 07m
1 stop
Delta Logo
6:00 am - 1:02 pm
STL
-
PTY
7h 02m
1 stop
$559Delta
Sat, May 30 - Tue, Jun 2
United Airlines Logo
10:55 pm - 12:11 pm
PTY
-
STL
13h 16m
2 stops
United Airlines Logo
8:37 am - 6:37 pm
STL
-
PTY
10h 00m
1 stop
$573United Airlines
Sat, May 30 - Tue, Jun 2
United Airlines Logo
10:55 pm - 3:21 pm
PTY
-
STL
16h 26m
2 stops
United Airlines Logo
6:40 am - 6:37 pm
STL
-
PTY
11h 57m
2 stops
$594United Airlines
Tue, Feb 24 - Sat, Feb 28
United Airlines Logo
4:41 pm - 12:21 pm
PTY
-
STL
20h 40m
2 stops
United Airlines Logo
3:15 pm - 2:45 pm
STL
-
PTY
22h 30m
2 stops
$616United Airlines
Tue, Feb 24 - Sat, Feb 28
United Airlines Logo
4:41 pm - 3:38 pm
PTY
-
STL
23h 57m
1 stop
United Airlines Logo
10:10 am - 5:07 pm
STL
-
PTY
29h 57m
1 stop
$631United Airlines
Sat, Feb 14 - Sun, Feb 22
Delta Logo
3:15 pm - 9:06 am
PTY
-
STL
18h 51m
1 stop
Delta Logo
6:56 pm - 1:50 pm
STL
-
PTY
17h 54m
1 stop
$645Delta
Fri, Feb 13 - Sun, Feb 22
United Airlines Logo
10:00 am - 10:59 pm
PTY
-
STL
13h 59m
2 stops
United Airlines Logo
6:00 am - 2:45 pm
STL
-
PTY
7h 45m
1 stop
$666United Airlines
Fri, Feb 13 - Sat, Feb 21
Avianca Logo
3:50 pm - 8:23 pm
PTY
-
STL
29h 33m
2 stops
Avianca Logo
8:30 am - 2:55 pm
STL
-
PTY
29h 25m
3 stops
$677Avianca
Sat, Feb 14 - Sat, Feb 21
Avianca Logo
7:50 pm - 10:13 am
PTY
-
STL
15h 23m
2 stops
Avianca Logo
8:30 am - 10:30 am
STL
-
PTY
25h 00m
2 stops
$685Avianca
Booking Insights

KAYAK's insights & trends for flights to St. Louis

Get data-powered insights and trends for flights to St. Louis to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly to St. Louis?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for flights to St. Louis, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights to St. Louis is June, where tickets cost $362 on average for one-way flights. On the other hand, the most expensive months are January and July, where the average cost of tickets from Panama is $664 and $659 respectively. For return trips, the best month to travel is June with an average price of $362.

Good to know

Low seasonApril
Cheapest flight$311
Best time to beat the crowds with an average 3% drop in price.
Most popular time to fly with an average 12% increase in price.
Flight from Panama City to St. Louis

FAQs - booking St. Louis flights

  • How far is Lambert-St Louis Airport from central St. Louis?

    The city center of St. Louis is 13 miles from Lambert-St Louis Airport.

  • What is the name of St. Louis’s airport?

    St. Louis is served by Lambert-St Louis Airport, also commonly referred to as Lambert Field, Lambert-St Louis, St. Louis Lambert, or St. Louis Lambert Intl. The airport code is STL.

  • How does KAYAK find such low prices on flights to St. Louis?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights to St. Louis.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket to St. Louis?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights to St. Louis?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to St. Louis with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight to St. Louis?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • How many direct flights to St. Louis are there each week?

    Each week there are around 1,771 direct flights from within Panama to St. Louis. The most common day for departures is Sunday, with 17% of flights taking off on this day.

Top tips for finding cheap flights to St. Louis

  • Enter your preferred departure airport and travel dates into the search form above to unlock the latest St. Louis flight deals.

Reviews of the top airline flying from Panama to St. Louis

 
See real verified KAYAK customer reviews for airlines flying to St. Louis. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline from Panama to St. Louis. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with to St. Louis? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9214 reviews
7.7Boarding
7.1Entertainment
6.6Food
7.3Comfort
8.1Crew
Airline reviews

In overall it was a good experience, the only down point was that the entertainment screen was working properly.

8.0 ExcellentAnonymous, Jan 2026
ORD - TPA
Read more United Airlines reviews

In overall it was a good experience, the only down point was that the entertainment screen was working properly.

This Japanese airline provides great service and very helpful in assisting their passengers.

Good crew. Boarding delays. Almost two hours wait for the bags in DC.

HORRIBLE, my initial flight was cancelled, they made me pay $200 extra dollars and that got cancelled as well! After 6 cancellations I decided to get a refund because I needed to get home to my babies. Out of $1000+ dollars they offered me only $40 in refund! Totally unacceptable! The flight that they cancelled I was able to fly it on another airline. I had to spend $400 on one way tickets just to get home! I’m still getting the runaround.

First class ticket gets you a choice of chips or nuts. . Just like economy Southwest. Also no screen in the seats. This is first class???!

Seated dude next to me even though lots of empty rows. But main thing was we sat on the tarmac after landing for 30 minutes because of, in the words of the dude who sat next to me, “operational incompetence”. We got changing directions about where to pick up gate checked bags. Pilot and flight attendant were awesome though.

It was a pretty standard flight... until the almost hour and a half spent on the taxi way. I get that the weather has been poor but the delay had nothing to do with the weather and more to do with a plane with several issues tying up the gate. I get that that happens from time to time but this has been EVERY flight I've been on for the past 5 years and I fly 3 to 5 times a year. This isn't just United... it's American, it's Delta. It's an issue with the entire industry. I work for UPS and packages on a cargo plane get better service than people do these days. Anymore I HATE flying.

I so appreciate the crew members on each flight of United. They are outstanding.

Flight arrived 30 min early and bag was waiting at the baggage pickup. United Club HNL was one of the nicest in the system

Unfortunately weather delayed our flight waiting for our plane to arrive and due to a little snow time was needed to deice the plane so departure was very delayed and I missed the connecting flight

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
O'Fallon
Wentzville
Farmington
Eureka
Litchfield
Grafton
Shrewsbury
Glencoe

Everything you need to know for your flight to St. Louis

Information on the airport you'll fly into in St. Louis