$340 Find Cheap Flights from Panama to South Carolina - Compare and Save

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Cheap Flights from Panama to South Carolina

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama to South Carolina

Thu, Nov 12 - Mon, Nov 16
United Airlines Logo
8:55 am - 9:30 amPTY  Panama City Tocumen Intl-GSP Greenville
24h 35m2 stops Houston George Bush Intcntl Chicago O'Hare Intl
United Airlines Logo
5:37 pm - 2:45 pmGSP  Greenville-PTY Panama City Tocumen Intl
21h 08m2 stops Chicago O'Hare Intl Houston George Bush Intcntl
$607United Airlines
Sat, Dec 19 - Sun, Jan 10
United Airlines Logo
11:55 pm - 11:59 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
24h 04m2 stops Newark Washington, D.C. Dulles Intl
United Airlines Logo
5:28 pm - 8:02 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
26h 34m2 stops Chicago O'Hare Intl Newark
$626United Airlines
Wed, Dec 23 - Sat, Jan 2
Delta Logo
8:00 am - 9:37 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
13h 37m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:50 am - 8:00 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
10h 10m1 stop Atlanta Hartsfield-Jackson
$626Delta
Wed, Dec 23 - Sat, Jan 2
Delta Logo
8:00 am - 4:09 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
8h 09m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:30 am - 8:00 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
12h 30m1 stop Atlanta Hartsfield-Jackson
$626Delta
Sat, Dec 19 - Sun, Jan 10
United Airlines Logo
11:55 pm - 9:23 amPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
9h 28m1 stop Newark
United Airlines Logo
7:47 pm - 5:12 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
21h 25m2 stops Washington, D.C. Dulles Intl Houston George Bush Intcntl
$626United Airlines
Wed, Dec 23 - Sat, Jan 2
United Airlines Logo
11:35 am - 10:46 amPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
23h 11m1 stop Houston George Bush Intcntl
United Airlines Logo
6:20 am - 7:38 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
13h 18m1 stop Houston George Bush Intcntl
$626United Airlines
Fri, Oct 30 - Fri, Nov 6
American Airlines Logo
2:02 pm - 11:08 amPTY  Panama City Tocumen Intl-GSP Greenville
20h 06m2 stops Miami Chicago O'Hare Intl
American Airlines Logo
4:37 pm - 2:13 pmGSP  Greenville-PTY Panama City Tocumen Intl
21h 36m2 stops Chicago O'Hare Intl Miami
$639American Airlines
Thu, Sep 10 - Fri, Oct 30
Multiple Airlines Logo
4:25 am - 9:14 pmPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
15h 49m2 stops Bogotá El Dorado Miami
Multiple Airlines Logo
9:41 pm - 1:20 amCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
28h 39m2 stops Miami Bogotá El Dorado
$644Multiple Airlines
Fri, Nov 27 - Mon, Nov 30
American Airlines Logo
3:34 pm - 8:15 amPTY  Panama City Tocumen Intl-CLT Charlotte Douglas
16h 41m1 stop Miami
American Airlines Logo
5:00 am - 2:34 pmCLT  Charlotte Douglas-PTY Panama City Tocumen Intl
9h 34m1 stop Miami
$648American Airlines
Fri, Oct 30 - Fri, Nov 6
American Airlines Logo
2:02 pm - 1:28 pmPTY  Panama City Tocumen Intl-GSP Greenville
22h 26m2 stops Miami Dallas/Fort Worth
American Airlines Logo
7:42 pm - 2:13 pmGSP  Greenville-PTY Panama City Tocumen Intl
18h 31m1 stop Miami
$651American Airlines
Booking Insights

KAYAK's insights & trends for flights to South Carolina

Get data-powered insights and trends for flights to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How many airports are there in South Carolina?

There are 6 airports in South Carolina. The busiest airport is Charleston Municipal Airport (CHS), with 40% of all flights arriving there.

How long is the flight to South Carolina?

An average nonstop flight from Panama to South Carolina takes 19h 50m, covering a distance of 1727 miles. The shortest route is Panama City (PTY) to Charlotte (CLT) with an average flight time of 11h 40m.

What are the most popular destinations in South Carolina?

Based on KAYAK flight searches, the most popular destination is Charlotte (76% of total searches to South Carolina). The next most popular destinations are Charleston (17%) and Columbia (4%). Searches for flights to Augusta (2%) and to Florence (2%) are also popular.

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Good to know

Low season

August

Cheapest flight

$340
Best time to beat the crowds but there is an average 13% increase in price.
Most popular time to fly and prices are also 26% lower on average.
Flight from Panama City to Charleston

FAQs for booking flights from Panama to South Carolina

  • How does KAYAK find such low prices on flights from Panama to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama to South Carolina

 
Need help choosing which airline to fly with from Panama to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 12027 reviews
6.8Entertainment
7.2Comfort
7.9Crew
7.5Boarding
6.4Food
Airline reviews

It was my first time flying with Alaska Airlines and it was a pleasure!

10.0 ExcellentJill, Aug 2026
Read more American Airlines reviews

It was my first time flying with Alaska Airlines and it was a pleasure!

DFW notification of changing the gate notice was an inconvenience.

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

Flight was good. Miss getting more options to eat than pretzels or cookies. Attendants were all wonderful.

For the price of the ticket you get nothing. The plane had 1 bathroom in the back and when the flight attendant did service no one could use it. No announcement just was told to go back to my seat. Ridiculous and rude.

In-flight Wi-Fi didn’t work and the flight was 25 minutes late. The Embraer plane I was on was pretty old and the tray table was broken.

American Airlines no longer has Bischoff biscuits. This is intolerable.

The waiting area in panama was super crowded, and hot

Everything you need to know for your flight to South Carolina

Cabin class types available on flights to South Carolina

First Class flights to South Carolina
Business Class flights to South Carolina
Premium Economy Class flights to South Carolina
Economy Class flights to South Carolina