$317 Find Cheap Flights from Panama City to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
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Cheap Flights from Panama City to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$386
Myrtle Beach
Myrtle Beach1 stop$586
Greenville
Greenville2 stops$506
Charlotte
Charlotte1 stop$409
Charleston
Charleston1 stop$386
Myrtle Beach
Myrtle Beach1 stop$586
Greenville
Greenville2 stops$506
Charlotte
Charlotte1 stop$409

Book Cheap Panama City to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South Carolina

Fri, Feb 6 - Fri, Mar 6
American Airlines Logo
2:27 pm - 11:55 pmPTY-CHS
9h 28m1 stop
American Airlines Logo
9:37 am - 3:00 pmCHS-PTY
5h 23m1 stop
$386American Airlines
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Fri, Feb 6 - Fri, Mar 6
American Airlines Logo
2:27 pm - 11:41 amPTY-CHS
21h 14m2 stops
American Airlines Logo
9:37 am - 3:00 pmCHS-PTY
5h 23m1 stop
$390American Airlines
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Wed, Dec 24 - Thu, Jan 1
United Airlines Logo
8:55 am - 9:42 pmPTY-CLT
12h 47m1 stop
United Airlines Logo
6:10 am - 5:07 pmCLT-PTY
10h 57m1 stop
$409United Airlines
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Fri, Feb 6 - Fri, Mar 6
American Airlines Logo
2:27 pm - 9:48 amPTY-CHS
19h 21m2 stops
American Airlines Logo
6:30 pm - 1:10 pmCHS-PTY
18h 40m2 stops
$409American Airlines
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Wed, Dec 3 - Wed, Dec 10
American Airlines Logo
4:43 pm - 8:07 amPTY-CLT
15h 24m1 stop
American Airlines Logo
5:15 am - 1:47 pmCLT-PTY
8h 32m1 stop
$424American Airlines
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Sun, Dec 21 - Mon, Jan 5
United Airlines Logo
4:41 pm - 10:41 amPTY-CLT
18h 00m1 stop
United Airlines Logo
6:23 am - 5:07 pmCLT-PTY
10h 44m1 stop
$430United Airlines
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Fri, Nov 7 - Mon, Nov 10
Multiple Airlines Logo
9:33 pm - 7:47 amPTY-CLT
10h 14m1 stop
Multiple Airlines Logo
10:42 pm - 8:06 amCLT-PTY
9h 24m1 stop
$445Multiple Airlines
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Sun, Nov 2 - Sat, Nov 15
Multiple Airlines Logo
9:33 pm - 7:47 amPTY-CLT
10h 14m1 stop
Multiple Airlines Logo
9:57 pm - 8:06 amCLT-PTY
10h 09m1 stop
$455Multiple Airlines
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Wed, Dec 3 - Tue, Jan 13
Delta Logo
3:46 pm - 11:49 pmPTY-CLT
8h 03m1 stop
Delta Logo
5:30 am - 2:02 pmCLT-PTY
8h 32m1 stop
$456Delta
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Mon, Dec 22 - Sat, Jan 3
Delta Logo
8:00 am - 10:11 pmPTY-CLT
14h 11m1 stop
Delta Logo
7:05 am - 1:57 pmCLT-PTY
6h 52m1 stop
$477Delta
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Booking Insights

KAYAK's insights & trends for Panama City to South Carolina flights

Get data-powered insights and trends into flights from Panama City to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Panama City to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Panama City to South Carolina departing in February.

What’s the cheapest day of the week to fly from Panama City to South Carolina?

The average price of all round-trip flights from Panama City to South Carolina clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from Panama City to South Carolina, look for departures on Wednesdays and avoid leaving on a Sunday, as it's usually the priciest day. When flying back from South Carolina, Wednesday is the cheapest day to fly and Sunday is the most expensive.

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Good to know

Low seasonJuly
Cheapest flight$288
Best time to beat the crowds with an average 16% drop in price.
Most popular time to fly with an average 2% increase in price.
Flight from Panama City to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Panama City to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally at night, when round-trip flights cost $469 on average. Morning departures are around 4% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the evening, which is peak travel time and where the average cost of a ticket is $554.

Reviews of the top airline flying from Panama City to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Panama City to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 11042 reviews
8.0Crew
6.4Food
7.2Comfort
6.9Entertainment
7.5Boarding
Airline reviews

Mostly good. Flight was crowded but Airline personnel were very friendly & accommodating. It would be good to have savory snacks rather than just sweet Biscoff cookies.

8.0 ExcellentMaryann, Oct 2025SFO - CLT
Read more American Airlines reviews

Mostly good. Flight was crowded but Airline personnel were very friendly & accommodating. It would be good to have savory snacks rather than just sweet Biscoff cookies.

It was a typical flight. We had a delay which seems to be the normality now. And we had no in flight service due to conditions.

Flight attendants on this flight were very attentive and friendly

After we landed we sat on the tarmac for 1.5 hours waiting to get to our gate. Ridiculous.

the trip to madrid was uncomfortable with my legs touching the seat in front of me

The plane was late, when we did board the plane was as cold as a freezer. I was freezing the entire flight, no blankets. Lost miserable flight I’ve ever had.

Flight, food and crew were all good, friendly and very satisfactory.

Terrible. Flight delayed for more than 8 hours with only a $12 meal voucher provided for the inconvenience. The airplane did not have breaks on arrival yet they still made us go through the motions and board on time knowing we could not take off then sit for 40+ minutes before having to get of the time. A complete waste of my time. I cannot believe they can stay business with these shenanigans. I’ll avoid this company like the plague moving forward as the lack of accountability is disgraceful.

This was the best 2 flights I have had with American out of SGF. Great crew both flights.

We were delayed for a “couple of maintenance issues.” They were resolved rather quickly but a computer glitch caused someone in the airport to have to bring a physical copy of the paperwork so we could leave. I don’t know where they had to drive from to get to our plane but it took forever & we were 1 1/2 hrs late in leaving. The flight itself was fine.

Everything you need to know for your flight from Panama City to South Carolina

Information on your arrival and departure airports

Panama City (PTY)

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