$302 Find Cheap Flights from Panama City to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 7/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Panama City to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston2 stops$577
Myrtle Beach
Myrtle Beach1 stop$742
Greenville
Greenville2 stops$583
Charlotte
Charlotte1 stop$551
Charleston
Charleston2 stops$577
Myrtle Beach
Myrtle Beach1 stop$742
Greenville
Greenville2 stops$583
Charlotte
Charlotte1 stop$551

Book Cheap Panama City to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South Carolina

Thu, Sep 10 - Mon, Sep 14
United Airlines Logo
3:30 pm - 10:54 am
PTY
-
CLT
18h 24m
1 stop
United Airlines Logo
7:55 pm - 7:31 pm
CLT
-
PTY
24h 36m
2 stops
$551United Airlines
Sat, Sep 26 - Fri, Oct 16
Copa Airlines Logo
6:41 pm - 9:44 am
PTY
-
CLT
14h 03m
1 stop
Copa Airlines Logo
6:00 am - 1:31 pm
CLT
-
PTY
8h 31m
1 stop
$560Copa Airlines
Fri, Aug 28 - Thu, Sep 17
American Airlines Logo
1:39 pm - 6:24 am
PTY
-
CLT
15h 45m
2 stops
American Airlines Logo
9:55 pm - 12:16 pm
CLT
-
PTY
15h 21m
1 stop
$564American Airlines
Tue, Aug 11 - Tue, Aug 18
United Airlines Logo
3:30 pm - 10:36 am
PTY
-
CHS
18h 06m
2 stops
United Airlines Logo
5:15 pm - 2:14 pm
CHS
-
PTY
21h 59m
1 stop
$577United Airlines
Fri, Aug 28 - Thu, Sep 17
American Airlines Logo
1:39 pm - 6:24 am
PTY
-
CLT
15h 45m
2 stops
American Airlines Logo
10:28 pm - 12:16 pm
CLT
-
PTY
14h 48m
2 stops
$578American Airlines
Wed, Dec 23 - Sat, Jan 2
United Airlines Logo
4:41 pm - 1:50 pm
PTY
-
CLT
21h 09m
2 stops
United Airlines Logo
8:05 am - 5:10 am
CLT
-
PTY
21h 05m
2 stops
$583United Airlines
Mon, Aug 31 - Wed, Sep 9
Delta Logo
2:20 pm - 2:12 pm
PTY
-
AGS
22h 52m
1 stop
Delta Logo
7:50 am - 12:58 pm
AGS
-
PTY
6h 08m
1 stop
$609Delta
Sat, Jul 18 - Tue, Jul 21
Multiple Airlines Logo
3:50 pm - 10:08 am
PTY
-
CHS
17h 18m
2 stops
Multiple Airlines Logo
8:14 pm - 1:55 am
CHS
-
PTY
30h 41m
2 stops
$636Multiple Airlines
Fri, Sep 4 - Mon, Sep 7
Delta Logo
2:20 pm - 5:54 pm
PTY
-
AGS
26h 34m
1 stop
Delta Logo
5:14 pm - 12:58 pm
AGS
-
PTY
20h 44m
1 stop
$641Delta
Fri, Jul 24 - Sun, Jul 26
Multiple Airlines Logo
3:50 pm - 10:03 am
PTY
-
CHS
17h 13m
2 stops
Multiple Airlines Logo
11:05 am - 10:30 am
CHS
-
PTY
24h 25m
2 stops
$677Multiple Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South Carolina flights

Get data-powered insights and trends into flights from Panama City to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Panama City to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to South Carolina is December, when tickets cost $148 (return) on average. On the other hand, the most expensive months are March and November, when the average cost of round-trip tickets is $715 and $530 respectively.

Find deals

Good to know

Low seasonMarch
Cheapest flight$302
Best time to beat the crowds but there is an average 30% increase in price.
Most popular time to fly and prices are also 13% lower on average.
Flight from Panama City to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Panama City to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Panama City to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11765 reviews
6.4Food
7.2Comfort
7.9Crew
6.8Entertainment
7.5Boarding
Airline reviews

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

4.0 OkayCaleb, Jun 2026
ORD - GSP
Read more American Airlines reviews

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

Flight was good. Miss getting more options to eat than pretzels or cookies. Attendants were all wonderful.

For the price of the ticket you get nothing. The plane had 1 bathroom in the back and when the flight attendant did service no one could use it. No announcement just was told to go back to my seat. Ridiculous and rude.

In-flight Wi-Fi didn’t work and the flight was 25 minutes late. The Embraer plane I was on was pretty old and the tray table was broken.

American Airlines no longer has Bischoff biscuits. This is intolerable.

The waiting area in panama was super crowded, and hot

Once we got on the flight everything was fine. The first leg of our flight was delayed 3 times but American sent us emails allowing us to chose a new itinerary.

Pros: "Nothing"
Cons: "Getting all my luggage. Allowing my wife and I to sit together"

Everything you need to know for your flight from Panama City to South Carolina

Information on your arrival and departure airports

Panama City (PTY)