$362 Find Cheap Flights from Panama City to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 6/25. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Panama City to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$532
Myrtle Beach
Myrtle Beach2 stops$819
Greenville
Greenville2 stops$532
Charlotte
Charlotte1 stop$497
Charleston
Charleston1 stop$532
Myrtle Beach
Myrtle Beach2 stops$819
Greenville
Greenville2 stops$532
Charlotte
Charlotte1 stop$497

Book Cheap Panama City to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South Carolina

Thu, Sep 10 - Mon, Sep 14
Delta Logo
2:21 pm - 11:57 pm
PTY
-
CLT
8h 36m
1 stop
Delta Logo
6:45 am - 12:56 pm
CLT
-
PTY
7h 11m
1 stop
$497Delta
Thu, Sep 10 - Mon, Sep 14
American Airlines Logo
3:40 pm - 7:49 am
PTY
-
CLT
15h 09m
2 stops
American Airlines Logo
9:00 pm - 2:10 pm
CLT
-
PTY
18h 10m
1 stop
$514American Airlines
Thu, Sep 10 - Mon, Sep 14
American Airlines Logo
3:40 pm - 7:49 am
PTY
-
CLT
15h 09m
2 stops
American Airlines Logo
10:25 pm - 2:10 pm
CLT
-
PTY
16h 45m
1 stop
$521American Airlines
Wed, Jul 1 - Fri, Jul 31
Delta Logo
2:24 pm - 12:36 am
PTY
-
CHS
9h 12m
1 stop
Delta Logo
6:15 am - 1:05 pm
CHS
-
PTY
7h 50m
1 stop
$532Delta
Wed, Sep 30 - Sat, Oct 31
American Airlines Logo
3:40 pm - 10:56 am
PTY
-
GSP
18h 16m
2 stops
American Airlines Logo
7:41 pm - 1:36 pm
GSP
-
PTY
18h 55m
2 stops
$532American Airlines
Wed, Sep 30 - Sun, Oct 25
American Airlines Logo
3:40 pm - 11:16 pm
PTY
-
GSP
6h 36m
1 stop
American Airlines Logo
4:56 pm - 2:00 pm
GSP
-
PTY
22h 04m
1 stop
$538American Airlines
Mon, Jun 8 - Tue, Jul 14
Delta Logo
2:24 pm - 11:59 pm
PTY
-
CLT
8h 35m
1 stop
Delta Logo
8:01 am - 1:05 pm
CLT
-
PTY
6h 04m
1 stop
$541Delta
Fri, Aug 28 - Mon, Aug 31
United Airlines Logo
3:30 pm - 1:58 pm
PTY
-
CHS
21h 28m
2 stops
United Airlines Logo
7:00 am - 6:37 pm
CHS
-
PTY
12h 37m
1 stop
$549United Airlines
Mon, Aug 3 - Mon, Aug 17
Delta Logo
2:20 pm - 11:57 pm
PTY
-
CLT
8h 37m
1 stop
Delta Logo
5:30 am - 12:55 pm
CLT
-
PTY
8h 25m
1 stop
$557Delta
Fri, Aug 28 - Mon, Aug 31
United Airlines Logo
3:30 pm - 4:02 pm
PTY
-
CHS
23h 32m
1 stop
United Airlines Logo
7:00 am - 6:37 pm
CHS
-
PTY
12h 37m
1 stop
$565United Airlines
Booking Insights

KAYAK's insights & trends for Panama City to South Carolina flights

Get data-powered insights and trends into flights from Panama City to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Panama City to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Panama City to South Carolina departing in July.

What is the cheapest month to fly from Panama City to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Panama City to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Panama City to South Carolina is December, when tickets cost $148 (return) on average. On the other hand, the most expensive months are March and November, when the average cost of round-trip tickets is $715 and $530 respectively.

Find deals

Good to know

Low seasonJuly
Cheapest flight$362
Best time to beat the crowds with an average 12% drop in price.
Most popular time to fly and prices are also 23% lower on average.
Flight from Panama City to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Panama City to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Panama City to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Panama City to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11662 reviews
7.9Crew
6.9Entertainment
7.2Comfort
7.5Boarding
6.4Food
Airline reviews

The airplane seats were spacious and comfortable, and the flight attendants were friendly and attentive. The food was delicious like never before. The blankets and toiletries were thoughtfully provided. The captain's navigation was steady and reliable. In short, having flown with Starlux, I won't consider any other airline next time.

10.0 ExcellentAnonymous, May 2026
GJT - PHX
Read more American Airlines reviews

The airplane seats were spacious and comfortable, and the flight attendants were friendly and attentive. The food was delicious like never before. The blankets and toiletries were thoughtfully provided. The captain's navigation was steady and reliable. In short, having flown with Starlux, I won't consider any other airline next time.

STOP MAKING THE SEATING SO CRAMPED. WE NEED A PASSENGER BILL OF RIGHTS!

The passenger in front of of me reclined their seat back all the way the entire flight. Their headrest was in my face the entire flight! I barely had room for the little plastic cup of water to fit on my tray table; can you make the seats and space between the rows any smaller??? You can’t even get up to use the restroom! Worst flight I’ve had in a very long time!

We had several flights and they were all on-time and flawless

My Frequent Flyer nber wasn't put on as I was told it was..... This resulted in a last group boarding and no priority tags on My bags.

Terrible steward... Plane was quite empty... I asked to move "back" in the plane and the steward said no... Unnecessary power trip of mediocre people.

The small flights with Valet Luggage has a poor service

not sure why you ask about food, I n3ver get food on flights except maybe cookies or pretzels. wifi was slow and in and out most of the flight not good.

Everything was fine except the end of the flight. We spent more than an hour circling around Miami due to weather conditions. That was not good.

They lost my bag. ... And I asked them 3 times to 3 different people if my checked bag will maKe it all the way - they all confirmed and at the end it was left at the connection... Bravo

Everything you need to know for your flight from Panama City to South Carolina

Information on your arrival and departure airports

Panama City (PTY)