$277 Find Cheap Flights from Panama City to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Panama City to South Carolina departing on 9/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Panama City to South Carolina, as well as popular online travel agencies
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Cheap Flights from Panama City to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$376
Myrtle Beach
Myrtle Beach3 stops$601
Greenville
Greenville1 stop$527
Charlotte
Charlotte1 stop$481
Charleston
Charleston1 stop$376
Myrtle Beach
Myrtle Beach3 stops$601
Greenville
Greenville1 stop$527
Charlotte
Charlotte1 stop$481

Book Cheap Panama City to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama City to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama City to South Carolina

Thu, Sep 4 - Mon, Sep 8
Delta Logo
2:05 pm - 11:51 pmPTY-CHS
8h 46m1 stop
Delta Logo
6:20 am - 12:50 pmCHS-PTY
7h 30m1 stop
$376Delta
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Thu, Sep 4 - Mon, Sep 8
American Airlines Logo
3:31 pm - 11:37 pmPTY-CHS
7h 06m1 stop
American Airlines Logo
7:28 pm - 12:55 pmCHS-PTY
18h 27m2 stops
$390American Airlines
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Thu, Sep 11 - Mon, Sep 15
American Airlines Logo
3:31 pm - 11:37 pmPTY-CHS
7h 06m1 stop
American Airlines Logo
7:08 am - 2:31 pmCHS-PTY
8h 23m1 stop
$405American Airlines
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Wed, Sep 17 - Sun, Sep 21
American Airlines Logo
1:45 pm - 11:37 pmPTY-CHS
8h 52m1 stop
American Airlines Logo
8:17 pm - 2:31 pmCHS-PTY
19h 14m2 stops
$409American Airlines
Find Deal
Fri, Oct 17 - Sat, Nov 1
United Airlines Logo
3:30 pm - 4:44 pmPTY-CHS
24h 14m1 stop
United Airlines Logo
6:00 am - 1:55 pmCHS-PTY
8h 55m1 stop
$415United Airlines
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Thu, Aug 28 - Mon, Sep 1
American Airlines Logo
3:30 pm - 10:09 amPTY-CHS
17h 39m1 stop
American Airlines Logo
7:50 pm - 2:30 pmCHS-PTY
19h 40m1 stop
$475American Airlines
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Wed, Dec 3 - Tue, Jan 13
United Airlines Logo
11:35 am - 10:51 amPTY-CLT
23h 16m1 stop
United Airlines Logo
4:45 pm - 7:38 pmCLT-PTY
26h 53m1 stop
$481United Airlines
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Thu, Aug 21 - Fri, Oct 24
 Logo
5:25 pm - 12:38 pmPTY-CLT
18h 13m2 stops
 Logo
6:00 am - 12:45 amCLT-PTY
19h 45m2 stops
Tue, Aug 26 - Wed, Nov 26
Copa Airlines Logo
10:29 pm - 9:49 amPTY-CAE
10h 20m1 stop
Copa Airlines Logo
10:34 am - 8:34 pmCAE-PTY
10h 00m1 stop
$1,337Copa Airlines
Find Deal
Mon, Aug 25 - Wed, Dec 3
Copa Airlines Logo
10:29 pm - 9:49 amPTY-CAE
10h 20m1 stop
Copa Airlines Logo
10:00 am - 8:34 pmCAE-PTY
10h 34m1 stop
$1,396Copa Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Panama City to South Carolina flights

Get data-powered insights and trends into flights from Panama City to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Panama City to South Carolina?

The average price of all round-trip flights from Panama City to South Carolina clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from Panama City to South Carolina, look for departures on Wednesdays and avoid leaving on a Sunday, as it's usually the priciest day. When flying back from South Carolina, Wednesday is the cheapest day to fly and Sunday is the most expensive.


Good to know

Low seasonJanuary
Cheapest flight$277
Best time to beat the crowds but there is an average 8% increase in price.
Most popular time to fly with an average 14% increase in price.
Flight from Panama City to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Panama City to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Panama City to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Panama City to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Panama City to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Panama City to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Panama City to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Panama City to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Panama City to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally at night, when round-trip flights cost $469 on average. Morning departures are around 4% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the evening, which is peak travel time and where the average cost of a ticket is $554.

Reviews of the top airline flying from Panama City to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Panama City to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Panama City to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 10000 reviews
8.0Crew
6.5Food
6.9Entertainment
7.2Comfort
7.5Boarding
Airline reviews

Dreadful experience. Our flight was delayed more than 8 hours due to a maintenance issue and the assistance from rebooking was poor. I was travelling with a bad knee and needed assistance waited in one place more than 3 hours before someone came with a wheelchair. The woman next to me was a 91 year old great grandmother who had waited more than 4 hours. There were moments of support from the staff but it appeared as they were going against the direction of management. It was apathy, lack of ownership and dismissive responses with small moments of kindness and understanding typically from grey haired, female, veteran staff..

6.0 Goodpaul, Aug 2025SEA - ORD
Read more American Airlines reviews

Dreadful experience. Our flight was delayed more than 8 hours due to a maintenance issue and the assistance from rebooking was poor. I was travelling with a bad knee and needed assistance waited in one place more than 3 hours before someone came with a wheelchair. The woman next to me was a 91 year old great grandmother who had waited more than 4 hours. There were moments of support from the staff but it appeared as they were going against the direction of management. It was apathy, lack of ownership and dismissive responses with small moments of kindness and understanding typically from grey haired, female, veteran staff..

Pathetic check in experience once again. Not enough staff scheduled at bag drop or for special assistance at LHR. Really need to rethink the whole self check in procedure. The crew was good. A very decent selection of special meals in this leg as compared to the JFK-LHR leg.

We had to turn around and head back to Manchester. Problem with a plane engine.

Flight was delayed. Staff at the gate effectively and proactively communicated about the delay.

Very poor delay in dfw was really bad n long

Our flight was 1.5 hours delayed. There was no weather for the inbound flight, so I don't understand why. This meant a VERY late arrival and only a quick nap before my morning flight.

Because of rescheduling, they had to put me on a flight that didn't go through Dallas

It was very difficult to stretch my knee out and I am very short. I also had a torn tendon in my knee which made it extra uncomfortable anyways. My husband is 6'2" and I can't imagine him flying in that plane.

3 hour weather delay followed by 1 hour (and counting) maintenance delay. UGH!

Couldn’t get the door on the plane to close leading to a nearly 2 hour delay. But, hey at least they didn’t cancel the flight.

Everything you need to know for your flight from Panama City to South Carolina

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