$105 Find Cheap Flights from San Antonio to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Antonio to South America departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Cheap Flights from San Antonio to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$303
Bogotá
Bogotá1 stop$289
Santiago
Santiago2 stops$613
Cartagena
Cartagena1 stop$360
Quito
Quito2 stops$595
Guayaquil
Guayaquil1 stop$300
Cali
Cali2 stops$334
Cusco
Cusco2 stops$429
Pereira
Pereira3 stops$450
Montevideo
Montevideo2 stops$965
Barranquilla
Barranquilla2 stops$462
Santa Marta
Santa Marta2 stops$732
Asuncion
Asuncion2 stops$920
Lima
Lima1 stop$303
Bogotá
Bogotá1 stop$289
Santiago
Santiago2 stops$613
Cartagena
Cartagena1 stop$360
Quito
Quito2 stops$595
Guayaquil
Guayaquil1 stop$300
Cali
Cali2 stops$334
Cusco
Cusco2 stops$429
Pereira
Pereira3 stops$450
Montevideo
Montevideo2 stops$965
Barranquilla
Barranquilla2 stops$462
Santa Marta
Santa Marta2 stops$732
Asuncion
Asuncion2 stops$920

Book Cheap San Antonio to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Antonio to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Antonio to South America

Thu, Mar 26 - Fri, Apr 3
Spirit Airlines Logo
10:22 am - 12:21 am
SAT
-
MDE
13h 59m
1 stop
Spirit Airlines Logo
1:17 am - 9:27 am
MDE
-
SAT
8h 10m
1 stop
$259Spirit Airlines
Thu, Mar 26 - Sun, Mar 29
Spirit Airlines Logo
10:22 am - 12:21 am
SAT
-
MDE
13h 59m
1 stop
Spirit Airlines Logo
1:17 am - 9:27 am
MDE
-
SAT
8h 10m
1 stop
$260Spirit Airlines
Sat, Apr 18 - Sat, Apr 25
Spirit Airlines Logo
10:26 am - 12:42 am
SAT
-
MDE
14h 16m
1 stop
Spirit Airlines Logo
2:10 pm - 9:30 am
MDE
-
SAT
19h 20m
1 stop
$282Spirit Airlines
Sat, Feb 14 - Thu, Feb 26
Multiple Airlines Logo
1:57 pm - 12:47 pm
SAT
-
BOG
21h 50m
1 stop
Multiple Airlines Logo
1:45 pm - 11:59 pm
BOG
-
SAT
11h 14m
1 stop
$295Multiple Airlines
Sat, Feb 21 - Wed, Mar 4
Multiple Airlines Logo
1:57 pm - 12:47 pm
SAT
-
BOG
21h 50m
1 stop
Multiple Airlines Logo
1:45 pm - 11:59 pm
BOG
-
SAT
11h 14m
1 stop
$298Multiple Airlines
Sun, Feb 22 - Wed, Feb 25
LATAM Airlines Logo
5:30 am - 2:17 pm
SAT
-
CTG
7h 47m
1 stop
LATAM Airlines Logo
3:32 pm - 12:35 am
CTG
-
SAT
10h 03m
1 stop
$461LATAM Airlines
Tue, Aug 4 - Tue, Aug 11
American Airlines Logo
5:59 pm - 12:11 pm
SAT
-
CUZ
18h 12m
2 stops
American Airlines Logo
10:02 pm - 11:25 pm
CUZ
-
SAT
25h 23m
2 stops
$898American Airlines
Sat, May 16 - Wed, May 20
LATAM Airlines Logo
2:27 pm - 8:35 am
SAT
-
SDU
16h 08m
2 stops
LATAM Airlines Logo
8:15 pm - 2:47 pm
SDU
-
SAT
20h 32m
2 stops
$1,201LATAM Airlines
Sun, May 31 - Mon, Jun 8
United Airlines Logo
5:30 am - 4:45 pm
SAT
-
SDU
33h 15m
2 stops
United Airlines Logo
1:45 pm - 11:03 am
SDU
-
SAT
23h 18m
2 stops
$1,238United Airlines
Mon, Mar 23 - Mon, Mar 30
United Airlines Logo
2:15 pm - 4:45 pm
SAT
-
SDU
24h 30m
2 stops
United Airlines Logo
1:45 pm - 8:42 am
SDU
-
SAT
20h 57m
2 stops
$1,241United Airlines
Booking Insights

KAYAK's insights & trends for San Antonio to South America flights

Get data-powered insights and trends into flights from San Antonio to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from San Antonio to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Antonio to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Antonio to South America is March, when tickets cost $619 (return) on average. On the other hand, the most expensive months are June and November, when the average cost of round-trip tickets is $779 and $774 respectively.

How far in advance should I book a flight from San Antonio to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Antonio to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Antonio to South America, you should book around 3 weeks before departure, which saves you about 11% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 20 weeks before departure.

Good to know

Low seasonApril
Cheapest flight$105
Best time to beat the crowds but there is an average 1% increase in price.
Most popular time to fly with an average 15% increase in price.
Flight from San Antonio to Medellín

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from San Antonio to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Antonio to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Antonio to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Antonio to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Antonio to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Antonio to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Antonio to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Antonio to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from San Antonio to South America

 
Need help choosing which airline to fly with from San Antonio to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8163 reviews
7.9Comfort
7.8Entertainment
7.2Food
8.5Crew
8.1Boarding
Airline reviews

Prior to takeoff, the pilot told us there was a possibility of not being able to land and going to Portland. Well that happened, we took off and then did 8 loops around Spokane before the pilot told us we ran out of fuel and had to go to Portland. So for a 35 minute flight we have now been on the plane for 3 hours (boarded at 6:50 am and landed in Portland at 10:30). Then, we just sat in Portland's airport with no updates of when we can start heading back. All of a sudden, our pilots and crew just left, leaving us stranded in a different city and state. We continued to sit in Portland until we finally got a new crew assigned and boarded the plane (This was from 10:30-2). We then sat on the plane for an additional hour before take off because they had to count us multiple times. We finally landed in Spokane at 3:55 PM. So a flight that should have taken at max an hour took us 10 hours and we missed the majority of the recruiting event we went for.

2.0 MediocreKeenan, Feb 2026
GEG - SEA
Read more Delta reviews

Prior to takeoff, the pilot told us there was a possibility of not being able to land and going to Portland. Well that happened, we took off and then did 8 loops around Spokane before the pilot told us we ran out of fuel and had to go to Portland. So for a 35 minute flight we have now been on the plane for 3 hours (boarded at 6:50 am and landed in Portland at 10:30). Then, we just sat in Portland's airport with no updates of when we can start heading back. All of a sudden, our pilots and crew just left, leaving us stranded in a different city and state. We continued to sit in Portland until we finally got a new crew assigned and boarded the plane (This was from 10:30-2). We then sat on the plane for an additional hour before take off because they had to count us multiple times. We finally landed in Spokane at 3:55 PM. So a flight that should have taken at max an hour took us 10 hours and we missed the majority of the recruiting event we went for.

It was delayed but other than that it was great.

Got on the plane and sat there for an hour before departure.

Second flight in a row where the entertainment system is broken. 5 hour long flight with no entertainment and flight attendants did not seem interested in resolving the matter. Very shocked to be treated this poorly considering I paid for a first class experience and have Diamond Medallion status.

They double booked seats, the gate staff changed my ticket as I was boarding she went over to the computer and changed it without telling me. She messed up an entire three row section for me and others. Other travelers were outraged but the gate staff were so rude, so condescending saying it wasn't their problem to solve. I would rate this a zero if I could. Will not fly Delta again I'll stick with United and American.

It was nt delta. It was aeromexo. Service was awful. They served a very small drink and NO snack for a 3hr and 35min flight. Then for the first 30 min of the flight is was talk and talk over head interruption the movie/ show i picked to watch.

Comfort seating was on the tight side. Maybe it was a smaller plane(?)

I was given middle seat on this flight and prior Boston to Seoul flight That is a problem for long flights, Kayak system did not give me a change to select my seats and assigned me middle seats regardless of my elevated status in Delta. This needs immediate attention.

I didn't take this flight. I changed the flight. Why am I getting surveys and notifications on flights that I change. Seems like a defect with Kayak.

Delta One is extraordinary. I fly business when somebody hires me. I just wonder why there is such a chasm between business class and the insanely inhumane and nonsensical coach. The seats are not large enough to fit even my tiny wife. We fly 10% of what we did because we don’t want to pay 5-10 k but for $400 it’s unbearable. It seems like the accountants took over and made stupid decisions. Screw in 20 extra seats and make it so unbearable that people fly 90% less. Just put the damn price up and put some proper chairs in. But business, yay.

Apart of Sky miles delta. And they go everywhere in Brazil

On board crew was very good. Crew was friendly, snacks were good, especially the chips. Seats seemed a bit cramped. Boarding seemed unorganized, as we were instructed to get to the gate an hour early and then just stood around until boarding.

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

The way the Pilot made all announcements, specially the way he congratulated the entire crew as the best team ever, making a comment that due to them they were able to shorter the delay to the destination. Amazing flight .

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

Really bad experience – delayed for 6 hours without any notice, no food or drinks provided, and stuck in the horrible Cartagena airport.

The flight was late. Please do not delay next time.

Delayed, toilets did not flush, pilot parked to far away from Gate

I like flying first class, and United has a nice one

Unbelievably poor service from flight attendants. They didn’t even do water service on a four hour flight. Just disrespectful.

Seats had less pitch than a regional jet. Food was OK. Have to buy alcohol on US based carriers flying international. Boarding was a mess. Did not have bags but overhead space was gone quick. Would like to see the airlines enforce the one bag over and one bag under policy

Lately I like the planes have been exceptionally filthy. There’s lines of dust and dirt all across the ceiling in the vents, and the cracks in between the seats are literally full of food. It’s definitely not the quality of service that I was used to with United. I’m also very disappointed with the Wi-Fi! All I wanna do is knock out a few work jobs while I’m trapped in my seat And it spools so bad. They did provide me with a refund, but the process of getting that refund is so complicated. It’s unfortunate.

Crew was excellent. This was a relatively long flight though and had very little leg room, and no entertainment.

The newer screen was super cool and had the option to watch many different shows or movies. Crew was polite and helpful. However again, many children screaming bloody murder and kicking my seat, and parents doing nothing about it as usual.

Flight was good and crew was super polite. However, there were around 5 kids screaming the WHOLE 2 hours. I understand kids have to come but parents need to do something to control their children. They make the experience terrible, especially after finishing 16 hour shifts at the hospital I needed some sleep, which I did not get.

Plane was crowded and even when we hit altitude, the plane was hot, not enough air flow.

Flight was delayed and missed my connection Lufthansa didn’t respond.

the plane was so hot!! the air-conditioning was barely blowing. The flight was delayed, and we had to sit on the hot plane before take off for an extended amount of time, waiting on international passengers. Would not have been so bad if it was not so hot. They said it would get better after take off, but it did not.

did not have enough meal for first class passengers so offer us snack

Old equipment, needs upgrade and seat comfort. Internet didn't work 75% or the time.

Update to handle the delay was very bad, crews no smiles or welcome or thanks. Don’t care attitude

No gates avail at DFW so our incoming had to wait 30 mins for a plane to push back because they Had mechanical. We boarded 90 mins delayed and then we had a mechanical. Come on American…do better. Also at my seat the tray table had not been cleaned. Floor had not been cleaned. But captain and flight Att were very picture and apologetic.

Flight was canceled. I asked to be rerouted to OKC and then took an Uber.

AA did not allow to board a flight because my connecting flight from DFW had been canceled. I got on another flight to another city. No service on the plane and I did not use their entertainment system.

I booked an aisle seat and was given a middle. At 6'4" 230lbs, it is not ideal to fly in the middle row for myself and passengers.

Concern Regarding Significant Gate Delay and Jet Bridge Issue Dear Customer Relations Team, I am writing to express my disappointment with the experience I had on my recent flight AA 2414 on Sunday January 18, 2026. What should have been a routine departure turned into a frustrating and avoidable delay due to an issue with the jet bridge at the gate. As a result, the flight was delayed by approximately 90 minutes while multiple gate changes were attempted. The lack of clear communication during this period made the situation even more challenging. Passengers were left uncertain about the cause of the delay, the expected timeline, and the next steps. This not only disrupted travel plans but also created unnecessary stress for everyone on board. I understand that operational issues can arise, but a malfunctioning jet bridge and the resulting extended delay suggest an area where procedures or equipment maintenance may need attention. I hope you will review this incident to prevent similar disruptions in the future. I would appreciate acknowledgment of this concern and consideration of appropriate compensation for the inconvenience and lost time caused by this delay. Thank you for taking the time to review my experience. I look forward to hearing from you. Sincerely, Dion Dillard

They made me pay $40 to check a bag that was listed as free when I bought my ticket. Then before boarding they offered to check any bags free.

Spirit was on time. They maintained updates and information. The crew was friendly and professional. Because this is a budget friendly airline, they have dispensed with a lot of frills and part of that comes with a price, for example, the seats are not quite as comfortable as others. I am ok with a pay for beverage and snack service as I prefer my own anyway so this was not a concern. I thought overall, having a great flight crew and on time service was definitely worth losing some of the frills from other carriers.

Sadly there was a crew member very rude with my kid and with me.

They canceled the flight and didn't assist in getting a new flight on any airline. I had to spend 10 hrs in the airport after getting a ticket On Delta for twice as much. I've flown Spirit many times and this was my worst experience I've had.

Late taking off. ATC sent us circling around Chicago for almost an hour, after landing taxied for 40 minutes.

We had too many delays for the crew not the plane

Awful!!! Spirit cancelled my flight just 4 hours before departure- with no alternative flights available. I ended up missing a huge family gathering because I wasn’t able to get out. Such An awful experience. And on top of that, all the buckle and dime-ing for bags. I will never book with Spirit EVER

I'd have like to check my bag and not toss my hair products.sears are very uncomfortable. And that even water isn't free really sucks. The ticket was almost $400

Terrible. They cancelled the flight at the last minute after I had checked in at the airport and then told me they could only put me on a flight after 7 days. Pathetic.

Spirit cancelled the flight very late last night, I was on the way to the airport when I found out

Flight was canceled and instead of rescheduling at the gate we had to go out to the ticket counter. Unruly kids kicking the back of my rows chair with staff to inattentive to say something.

Everything you need to know for your flight to South America

Information on your arrival and departure airports