$354 Find Cheap Flights from San Diego to Panama - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Diego to Panama departing on 10/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from San Diego to Panama

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Panama City
Panama Citynonstop$570
David
David2 stops$1,028
Panama City
Panama Citynonstop$570
David
David2 stops$1,028

Book Cheap San Diego to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Diego to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Diego to Panama

Mon, Aug 31 - Sun, Sep 13
Copa Airlines Logo
10:00 pm - 6:22 am
SAN
-
PTY
6h 22mnonstop
Copa Airlines Logo
1:55 pm - 6:30 pm
PTY
-
SAN
6h 35mnonstop
$570Copa Airlines
Fri, Sep 25 - Fri, Oct 2
United Airlines Logo
2:24 pm - 6:37 pm
SAN
-
PTY
26h 13m
2 stops
United Airlines Logo
10:00 am - 5:46 pm
PTY
-
SAN
9h 46m
1 stop
$576United Airlines
Mon, Aug 31 - Sun, Sep 13
Delta Logo
10:25 pm - 12:55 pm
SAN
-
PTY
12h 30m
1 stop
Delta Logo
2:21 pm - 10:44 pm
PTY
-
SAN
10h 23m
1 stop
$585Delta
Mon, Sep 14 - Fri, Sep 25
United Airlines Logo
8:00 am - 6:37 pm
SAN
-
PTY
8h 37m
1 stop
United Airlines Logo
3:30 pm - 11:35 am
PTY
-
SAN
22h 05m
2 stops
$589United Airlines
Mon, Aug 31 - Sun, Sep 13
Delta Logo
10:25 pm - 12:55 pm
SAN
-
PTY
12h 30m
1 stop
Delta Logo
2:21 pm - 10:44 pm
PTY
-
SAN
10h 23m
1 stop
$595Delta
Wed, Sep 9 - Sun, Sep 13
United Airlines Logo
8:00 am - 6:37 pm
SAN
-
PTY
8h 37m
1 stop
United Airlines Logo
3:30 pm - 10:58 am
PTY
-
SAN
21h 28m
1 stop
$597United Airlines
Mon, Oct 5 - Fri, Oct 9
United Airlines Logo
5:00 pm - 2:14 pm
SAN
-
PTY
19h 14m
2 stops
United Airlines Logo
10:00 am - 12:31 am
PTY
-
SAN
16h 31m
2 stops
$599United Airlines
Fri, Oct 9 - Mon, Oct 12
United Airlines Logo
6:50 pm - 6:37 pm
SAN
-
PTY
21h 47m
2 stops
United Airlines Logo
3:30 pm - 5:46 pm
PTY
-
SAN
28h 16m
1 stop
$602United Airlines
Fri, Oct 9 - Mon, Oct 12
United Airlines Logo
4:46 pm - 6:37 pm
SAN
-
PTY
23h 51m
1 stop
United Airlines Logo
3:30 pm - 1:17 pm
PTY
-
SAN
23h 47m
1 stop
$609United Airlines
Thu, Oct 29 - Sun, Nov 8
Delta Logo
9:40 pm - 12:56 pm
SAN
-
PTY
13h 16m
1 stop
Delta Logo
3:21 pm - 11:03 pm
PTY
-
SAN
10h 42m
1 stop
$620Delta
Booking Insights

KAYAK's insights & trends for San Diego to Panama flights

Get data-powered insights and trends into flights from San Diego to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest San Diego to Panama flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to Panama from San Diego found in the last 5 days was to Panama City, at $200 round-trip. The most popular route is from San Diego (SAN) to Panama City (PTY), and the cheapest round-trip airline ticket found on this route in the last 5 days was $200.

What is the cheapest time of day to fly to Panama?

The average price for all round-trip flights from San Diego to Panama depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to Panama is generally at night, when round-trip flights cost $537 on average. The most expensive time of day to fly to Panama is generally at night, which is peak travel time and where the average cost of a ticket is $537.

Can I save money by flying with a layover from San Diego to Panama?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $651 on average.

What is the cheapest month to fly from San Diego to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Diego to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Diego to Panama is September, when tickets cost $169 (return) on average. On the other hand, the most expensive months are April and June, when the average cost of round-trip tickets is $510 and $436 respectively.

What’s the cheapest day of the week to fly from San Diego to Panama?

The average price of all round-trip flights from San Diego to Panama clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from San Diego to Panama, look for departures on Wednesdays and avoid leaving on a Saturday, as it's usually the priciest day. When flying back from Panama, Monday is the cheapest day to fly and Wednesday is the most expensive.

How far in advance should I book a flight from San Diego to Panama?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Diego to Panama, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Diego to Panama, you should book around 3 weeks before departure, which saves you about 29% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 16 weeks before departure.

Good to know

Low seasonJune
Cheapest flight$354
Best time to beat the crowds but there is an average 22% increase in price.
Most popular time to fly and prices are also 5% lower on average.
Flight from San Diego to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from San Diego to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Diego to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Diego to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Diego to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Diego to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Diego to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Diego to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Diego to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from San Diego to Panama

 
Need help choosing which airline to fly with from San Diego to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1567 reviews
6.8Entertainment
8.1Crew
7.8Boarding
7.4Comfort
6.9Food
Airline reviews

They didn’t have any headphones for the entertainment screen and their USB port didn’t accommodate a USB-C for more modern phones. The food was just ok. The staff was friendly but the seats were very uncomfortable for a full flight.

6.0 GoodAnonymous, May 2026
SCL - PTY
Read more Copa Airlines reviews

They didn’t have any headphones for the entertainment screen and their USB port didn’t accommodate a USB-C for more modern phones. The food was just ok. The staff was friendly but the seats were very uncomfortable for a full flight.

I had to run from the end of terminal one to the end of terminal two to make the connecting flight....probably a kilometer. No electric carts were available. I'm 76 and literally had to run to make the connection at the last minute. The connecting time was absolutely unrealistic. When Last Call was announced, I tried to get other Copa gate staff to call Gate 221 to let them know I was on my way, but they said no. I came within 1 minute of missing the flight.

I was flying business class, and the French fellow passengers were super noisy. It was not a comfortable flight. And the crew was not helpful.

Boarding was a mess, they call all priority members without distinction so gold, platinum, silver were all mixed together in a long line which defeats the purpose

Entire experience from check in to landing was amazing the flight crew was excellent and friendly. Seats were comfortable.

Boarding was confusing from staff telling going to preboard and than to group 1 Airplane was not cooling at the beginning

Avoid at all costs. My wife had to stay back on a connecting flight as her parents flight was delayed. 10 days later on the way back they cancelled all our flights. We had to rebook all four of us on the next days flight.

Friendly crew, good food options, food not the best and seats not as comfy but that’s typical.

The food is terrible I ask for water never got transport my mother we’re late and my sister from Lima was the worst waiting to long for wheelchair

Seats were awful. Media should have been included for such a long flight.

I was promised by United Airline (operated by ANA) that I will be seated together with my kids as I am the only adult flying with two minors. We did not get seats together in our 11 hours flight from LA to Tokyo. When asked at the gate, ANA representative said United Airline should have informed them that there is a parent flying with two minors. He said they can’t do anything in the system as the flight is full. He ask me to ask passengers next to me and the kids if they are willing to change seats. This is ridiculous! However, I went in the flight and asked other passages but no one willing to change seats. 11 hours and we were seating separately. I was very disappointed with this. It made things super inconvenient for me.

Service was professional and quick. Premium economy seat was comfortable given the class

It was perfect! United Airlines staff was extremely caring, super friendly and professional

The staff was extremely helpful and friendly at all times! They went above and beyond to get us into an earlier flight in San Diego to make our connection in SFO possible, because our original flight did actually not make it! I did so much appreciate the UA team and how they made this possible. We also didn’t have seats together on the long flight to Singapore, but they found us seats together last moment with no additional cost! Nobody sat next to us, so that we were able to sleep! Thanks to UA for improving their service and Underpricer for booking this trip! Please be careful: 1,5 hrs for transfer in San Francisco might not be enough time in the future

Over 2.5 hour maintenance delay on first morning flight with no acknowledgement, compensation or even gesture of good will. Aircraft had overnighted at airport so issue should have been addressed prior to boarding. Over 3.5 hours before first slow and deliberate beverage service.

United has maintenance issues and can then never recover. No operations ability and simple issues always turn into multiple hours long cascading delays. Worst airline on earth.

I paid for a confirmed upgraded aisle seat and was moved to a center seat in the back of the plane at the last minute.

Horrifying Almost 2 million miles. Bring your own food and drink. One coffee or drink every three hours. Have to order meals on app more than 24 hours ahead Tiny and dirty bathrooms

Flight was delayed but more than 90 minutes. This caused me to miss my available windows for pick-up by a friend. I had to pay $125 for an uber back home from the airport which was an added expense that I had not budgeted for my trip. Staff was friendly.

Seat pitch is horrible especially on the 15 hour flight. Gate crew at SFO was Outstanding. The flight crew was also great.

Everything you need to know for your flight from San Diego to Panama

Information on your arrival and departure airports