$448 Find Cheap Flights from Panama to San Diego - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Diego departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Panama to San Diego

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama to San Diego that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama to San Diego

Fri, Sep 4 - Fri, Oct 2
Copa Airlines Logo
1:54 pm - 6:29 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 35mnonstop
Copa Airlines Logo
10:00 pm - 6:13 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 13mnonstop
$558Copa Airlines
Wed, Sep 2 - Wed, Sep 9
Copa Airlines Logo
1:54 pm - 6:29 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 35mnonstop
Copa Airlines Logo
10:00 pm - 6:17 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 17mnonstop
$558Copa Airlines
Fri, Nov 20 - Sun, Nov 22
Copa Airlines Logo
1:45 pm - 5:15 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 30mnonstop
Copa Airlines Logo
10:00 pm - 7:06 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 06mnonstop
$558Copa Airlines
Sun, Sep 6 - Sun, Sep 13
Copa Airlines Logo
1:54 pm - 6:29 pmPTY  Panama City Tocumen Intl-SAN San Diego
6h 35mnonstop
Copa Airlines Logo
10:00 pm - 6:17 amSAN  San Diego-PTY Panama City Tocumen Intl
6h 17mnonstop
$558Copa Airlines
Fri, Oct 16 - Tue, Oct 27
United Airlines Logo
3:30 pm - 3:40 pmPTY  Panama City Tocumen Intl-SAN San Diego
26h 10m1 stop Houston George Bush Intcntl
United Airlines Logo
6:26 pm - 1:45 pmSAN  San Diego-PTY Panama City Tocumen Intl
17h 19m2 stops San Francisco Houston George Bush Intcntl
$564United Airlines
Fri, Sep 4 - Fri, Oct 2
United Airlines Logo
3:30 pm - 5:46 pmPTY  Panama City Tocumen Intl-SAN San Diego
28h 16m1 stop Houston George Bush Intcntl
United Airlines Logo
3:00 pm - 6:37 pmSAN  San Diego-PTY Panama City Tocumen Intl
25h 37m1 stop Houston George Bush Intcntl
$564United Airlines
Fri, Sep 4 - Fri, Oct 2
United Airlines Logo
3:30 pm - 11:35 amPTY  Panama City Tocumen Intl-SAN San Diego
22h 05m2 stops Houston George Bush Intcntl Los Angeles Los Angeles
United Airlines Logo
3:56 pm - 6:37 pmSAN  San Diego-PTY Panama City Tocumen Intl
24h 41m3 stops San Francisco Denver Intl Houston George Bush Intcntl
$564United Airlines
Sun, Sep 13 - Fri, Sep 18
Delta Logo
2:23 pm - 10:54 pmPTY  Panama City Tocumen Intl-SAN San Diego
10h 31m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:45 pm - 12:58 pmSAN  San Diego-PTY Panama City Tocumen Intl
13h 13m1 stop Atlanta Hartsfield-Jackson
$585Delta
Thu, Nov 5 - Mon, Nov 9
American Airlines Logo
3:13 pm - 11:01 amPTY  Panama City Tocumen Intl-SAN San Diego
22h 48m2 stops Miami Chicago O'Hare Intl
American Airlines Logo
4:31 pm - 2:13 pmSAN  San Diego-PTY Panama City Tocumen Intl
18h 42m2 stops Dallas/Fort Worth Miami
$599American Airlines
Thu, Nov 5 - Mon, Nov 9
American Airlines Logo
3:13 pm - 11:38 pmPTY  Panama City Tocumen Intl-SAN San Diego
11h 25m1 stop Miami
American Airlines Logo
3:13 pm - 2:13 pmSAN  San Diego-PTY Panama City Tocumen Intl
20h 00m2 stops Dallas/Fort Worth Miami
$599American Airlines
Booking Insights

KAYAK's insights & trends for flights to San Diego

Get data-powered insights and trends for flights to San Diego to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest day to fly to San Diego?

The average price of all round-trip flights to San Diego clicked on KAYAK for each day over the last 12 months.

Based on KAYAK data, the cheapest day to fly to San Diego is Monday where round-trip tickets can be as cheap as $334. On the other hand, the most expensive day to fly is Tuesday, where round-trip prices are $516 on average.

What is the cheapest month to fly to San Diego?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights to San Diego, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights to San Diego is November, where tickets cost $434 on average for return flights. On the other hand, the most expensive months are June and April, where the average cost of tickets from Panama is $1,217 and $881 respectively. For one-way flights, the best month to travel is December with an average price of $244.

What is the cheapest time of day to fly to San Diego?

The average price for all round-trip flights to San Diego depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to San Diego is generally in the afternoon, when round-trip flights cost $513 on average. The most expensive time of day to fly to San Diego is generally in the afternoon, which is peak travel time and where the average cost of a ticket is $513.

Good to know

Low season

June

Cheapest flight

$448
Best time to beat the crowds but there is an average 70% increase in price.
Most popular time to fly and prices are also 21% lower on average.
Flight from Panama City to San Diego

FAQs - booking San Diego flights

  • How far is San Diego Airport from central San Diego?

    The distance between San Diego Airport and downtown San Diego is 3 miles.

  • What is the name of San Diego’s airport?

    San Diego is served by San Diego Airport, also commonly referred to as Lindbergh Field, San Diego, or San Diego Intl. The airport code is SAN.

  • How much is a flight to San Diego?

    On average, a flight to San Diego costs $513. The cheapest price found on KAYAK in the last 2 weeks cost $378 and departed from Panama City Tocumen Intl Airport.

  • How does KAYAK find such low prices on flights to San Diego?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights to San Diego.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket to San Diego?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Diego is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights to San Diego?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Diego with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight to San Diego?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Diego up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • How many direct flights to San Diego are there each week?

    Each week there are around 6,078 direct flights from within Panama to San Diego. The most common day for departures is Sunday, with 18% of flights taking off on this day.

Top tips for finding cheap flights to San Diego

  • Enter your preferred departure airport and travel dates into the search form above to unlock the latest San Diego flight deals.

Reviews of the top airlines flying from Panama to San Diego

 
See real verified KAYAK customer reviews for airlines flying to San Diego. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline from Panama to San Diego. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with to San Diego? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1563 reviews
8.1Crew
7.4Comfort
7.8Boarding
6.8Entertainment
6.9Food
Airline reviews

stood in line to check in luggage for nearly an hour. very poor service and not excusable

4.0 OkayAnonymous, Jun 2026
Read more Copa Airlines reviews

stood in line to check in luggage for nearly an hour. very poor service and not excusable

Same as the previous flight as far as comfort and food. Entertainment didn’t have a watchable screen so everything would need to be watched on your own device in which they didn’t have a charging port that accommodated my iPhone. Seats were very uncomfortable. Staff was very friendly.

Do not book it’s a scam! They stole $1200 from me

Flight got delayed; had to go through security three times.

A lot things happened in this trip.The fly should be less stress.

Some of the Air hostesses are not that friendly. Need improvement

Had to go through security at the gate again. Had to take off shoes and go through the whole thing again even though we have global entry. They asked us to check in items bought at duty free during our layover and since we checked our luggage at the original departure airport, they forced us to check in a small backpack. None of this ever happened with other airlines. In addition, no vegetarian food option and no snacks during a 7 hr flight. Luggage limits are unusually small. This is unacceptable. Will NEVER fly Copa again and will tell friends and family to avoid this airline.

I upgraded myself to Business Class at the last minute so I had a DREAMS window seat. Seeing as I've never flown Business before everything was novel and fun for me and it made the 7 hour flight much more enjoyable for sure.

Horrible food. No wine or any other alcohol is served on the flight. Water is not served often and they refused when I asked for water in two cups. On the other hand, both going and coming back flights were on time.

it was great! Boarded on-time, reasonable leg room, pleasant staff, decent food. The only thing is we were directed to Terminal 2 when the gate was actually in Terminal 1. Smooth ride. Landed early. Got off plane easily and quickly.

Old 757 with poor entertainment system. United no longer partners with United for free text and email. O'Hara an absolute disaster! Limited gates clauses two hour delay. Unfortunately this appears to be the norm.

The entire experience convinced my wife, Cathy, and me that traveling Polaris on United is the only way we’ll fly in the future. From check-in and baggage drop to the end of the 12-hour flight, the customer service was exceptional, with numerous staff members exemplifying the very best in care. On board, Andre, our primary crew chief, was sincerely friendly, a consummate professional, and, along with Freddy, one of his team members, truly among the best of the best. The captain even came through the cabin to chat with passengers—a wonderful personal touch, especially on such a long journey.

Delayed 2 hours while stuck on the aircraft. If the luggage was properly loaded the first time we probably wouldn’t have been delayed at all

UA594 was delayed multiple times. I ended up getting picked up so I can make it in time for work 6AM on Monday, 7/6/2026

Horrific. They missed my connecting flight to San Diego. I didn’t get there until Monday at 9am when I had a mandatory court settlement conference scheduled at 6am since we had parties on the east coast. This caused many issues. All because United apparently forgot to hold the doors open until my flight landed that only had a 10 minute delay. This was the last flight to Southern California. So I couldn’t even rent a car to finish the trip. United cannot be trusted when traveling on specific days and times since weather didn’t have anything to do with the delays.

Was a pain having to leave the plane and reboard but glad the plane was fixed

Connecting flights were poor,especially in Naples.our Lufthansa air bus was a joke.way too small for that long of a flight.no room at all.couldn’t even get out of the seats to move around or go to the bathrooms.we thought we were getting an actual air bus,double decker.i will never fly that long in a plane like that again.kind of misleading to call it an air bus.we actually had more room on our buses that we used.

For a 22 minute flight all you expect is for it to be safe and comfortable

Lost connnection had to stayON in Chicago Was a mess

Booked economy through United - air canada treated it as standby and was almost refused boarding.

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
National City
Julian
Borrego Springs
Poway
Alpine
Santee
Lemon Grove

Everything you need to know for your flight to San Diego

Information on the airport you'll fly into in San Diego