$381 Find Cheap Flights from Panama to San Diego - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to San Diego departing on 8/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Panama to San Diego

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Panama to San Diego that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Panama to San Diego

Wed, Sep 30 - Wed, Oct 7
Multiple Airlines Logo
5:30 am - 5:10 pm
PTY
-
SAN
13h 40m
2 stops
Multiple Airlines Logo
7:48 pm - 10:30 am
SAN
-
PTY
12h 42m
2 stops
$768Multiple Airlines
Mon, Nov 2 - Wed, Nov 11
Multiple Airlines Logo
9:31 pm - 3:41 pm
PTY
-
SAN
21h 10m
2 stops
Multiple Airlines Logo
12:35 pm - 8:20 am
SAN
-
PTY
16h 45m
1 stop
$770Multiple Airlines
Wed, Aug 26 - Thu, Sep 10
Multiple Airlines Logo
5:30 am - 5:10 pm
PTY
-
SAN
13h 40m
2 stops
Multiple Airlines Logo
11:19 am - 1:55 am
SAN
-
PTY
12h 36m
2 stops
$777Multiple Airlines
Sun, Sep 13 - Fri, Sep 18
Multiple Airlines Logo
5:30 am - 8:02 pm
PTY
-
SAN
16h 32m
2 stops
Multiple Airlines Logo
7:59 pm - 10:30 am
SAN
-
PTY
12h 31m
2 stops
$779Multiple Airlines
Sun, Sep 13 - Fri, Sep 18
Multiple Airlines Logo
5:30 am - 8:02 pm
PTY
-
SAN
16h 32m
2 stops
Multiple Airlines Logo
7:59 pm - 10:30 am
SAN
-
PTY
12h 31m
2 stops
$784Multiple Airlines
Sun, Sep 13 - Fri, Sep 18
Copa Airlines Logo
1:55 pm - 6:30 pm
PTY
-
SAN
6h 35mnonstop
Copa Airlines Logo
10:00 pm - 6:17 am
SAN
-
PTY
6h 17mnonstop
$787Copa Airlines
Tue, Aug 25 - Fri, Aug 28
Multiple Airlines Logo
5:30 am - 7:55 pm
PTY
-
SAN
16h 25m
2 stops
Multiple Airlines Logo
7:59 pm - 10:30 am
SAN
-
PTY
12h 31m
2 stops
$788Multiple Airlines
Wed, Dec 23 - Mon, Jan 11
United Airlines Logo
11:35 am - 11:51 pm
PTY
-
SAN
15h 16m
2 stops
United Airlines Logo
8:00 am - 7:38 pm
SAN
-
PTY
8h 38m
1 stop
$790United Airlines
Sun, Sep 13 - Fri, Sep 18
Delta Logo
2:23 pm - 10:55 pm
PTY
-
SAN
10h 32m
1 stop
Delta Logo
9:45 pm - 12:58 pm
SAN
-
PTY
13h 13m
1 stop
$793Delta
Thu, Oct 29 - Mon, Nov 2
United Airlines Logo
7:55 am - 5:53 pm
PTY
-
SAN
11h 58m
1 stop
United Airlines Logo
5:00 pm - 2:45 pm
SAN
-
PTY
18h 45m
1 stop
$802United Airlines
Booking Insights

KAYAK's insights & trends for flights to San Diego

Get data-powered insights and trends for flights to San Diego to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest day to fly to San Diego?

The average price of all round-trip flights to San Diego clicked on KAYAK for each day over the last 12 months.

Based on KAYAK data, the cheapest day to fly to San Diego is Monday where round-trip tickets can be as cheap as $334. On the other hand, the most expensive day to fly is Wednesday, where round-trip prices are $714 on average.

What is the cheapest month to fly to San Diego?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights to San Diego, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights to San Diego is November, where tickets cost $434 on average for return flights. On the other hand, the most expensive months are June and April, where the average cost of tickets from Panama is $1,217 and $881 respectively. For one-way flights, the best month to travel is December with an average price of $244.

What is the cheapest time of day to fly to San Diego?

The average price for all round-trip flights to San Diego depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to San Diego is generally in the afternoon, when round-trip flights cost $460 on average. The most expensive time of day to fly to San Diego is generally in the afternoon, which is peak travel time and where the average cost of a ticket is $460.

Good to know

Low season

June

Cheapest flight

$381
Best time to beat the crowds but there is an average 71% increase in price.
Most popular time to fly and prices are also 21% lower on average.
Flight from Panama City to San Diego

FAQs - booking San Diego flights

  • How far is San Diego Airport from central San Diego?

    The distance between San Diego Airport and downtown San Diego is 3 miles.

  • What is the name of San Diego’s airport?

    San Diego is served by San Diego Airport, also commonly referred to as Lindbergh Field, San Diego, or San Diego Intl. The airport code is SAN.

  • How much is a flight to San Diego?

    On average, a flight to San Diego costs $378. The cheapest price found on KAYAK in the last 2 weeks cost $378 and departed from Panama City Tocumen Intl Airport.

  • How does KAYAK find such low prices on flights to San Diego?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights to San Diego.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket to San Diego?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Diego is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights to San Diego?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Diego with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight to San Diego?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Diego up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • How many direct flights to San Diego are there each week?

    Each week there are around 5,067 direct flights from within Panama to San Diego. The most common day for departures is Sunday, with 16% of flights taking off on this day.

Top tips for finding cheap flights to San Diego

  • Looking for cheap airfare to San Diego? 25% of our users found round-trip tickets to San Diego for the following prices or less: From Panama City $378
  • Enter your preferred departure airport and travel dates into the search form above to unlock the latest San Diego flight deals.

Reviews of the top airlines flying from Panama to San Diego

 
See real verified KAYAK customer reviews for airlines flying to San Diego. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline from Panama to San Diego. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with to San Diego? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1565 reviews
7.4Comfort
6.9Food
7.8Boarding
8.1Crew
6.8Entertainment
Airline reviews

stood in line to check in luggage for nearly an hour. very poor service and not excusable

4.0 OkayAnonymous, Jun 2026
PTY - AUS
Read more Copa Airlines reviews

stood in line to check in luggage for nearly an hour. very poor service and not excusable

Same as the previous flight as far as comfort and food. Entertainment didn’t have a watchable screen so everything would need to be watched on your own device in which they didn’t have a charging port that accommodated my iPhone. Seats were very uncomfortable. Staff was very friendly.

Do not book it’s a scam! They stole $1200 from me

Flight got delayed; had to go through security three times.

A lot things happened in this trip.The fly should be less stress.

Some of the Air hostesses are not that friendly. Need improvement

Had to go through security at the gate again. Had to take off shoes and go through the whole thing again even though we have global entry. They asked us to check in items bought at duty free during our layover and since we checked our luggage at the original departure airport, they forced us to check in a small backpack. None of this ever happened with other airlines. In addition, no vegetarian food option and no snacks during a 7 hr flight. Luggage limits are unusually small. This is unacceptable. Will NEVER fly Copa again and will tell friends and family to avoid this airline.

I upgraded myself to Business Class at the last minute so I had a DREAMS window seat. Seeing as I've never flown Business before everything was novel and fun for me and it made the 7 hour flight much more enjoyable for sure.

Horrible food. No wine or any other alcohol is served on the flight. Water is not served often and they refused when I asked for water in two cups. On the other hand, both going and coming back flights were on time.

it was great! Boarded on-time, reasonable leg room, pleasant staff, decent food. The only thing is we were directed to Terminal 2 when the gate was actually in Terminal 1. Smooth ride. Landed early. Got off plane easily and quickly.

We boarded the plane and were about to take off when we were notified that the tires had to be checked. Upon inspection, they were found to need replacement, so the entire plane had to be deboarded. After we exited the plane, United staff forced us to stay in the gate area by posting "Do Not Exit" signs on the doors connecting the gate area to the terminal. Many of us had already rebooked our flights and had no checked bags, but they told us we could not leave. This seemed inappropriate to hold people under false pretenses. When the agent told us we could leave, I asked them to please take down the "Do Not Exit" signs, as they were misleading. The agent refused, and I told them that it didn't feel right to hold people like that.

It was a short, comfortable flight. It did leave an hour late due to the pilot having to be replaced (family emergency) but that didn’t inconvenience myself & my friend. The situation was explained, eventually.

There was a piece of plastic baked into my buttermilk biscuit! I have a pictures. The flight attendants in first class were really apologetic, and tried to rectify the situation. I I am very appreciative that they were able to give me some packets of pretzels and gummy bears. I understand they don't personally handle the food until warming it up so I know it wasn't their fault. I don't know whether it was a newer aircraft, or different food packaging, but I was happy that when the food was being warmed up - it didn't smell like plastic. Jokes on me with finding plastic in my food.

UA594 was delayed multiple times. I ended up getting picked up so I can make it in time for work 6AM on Monday, 7/6/2026

Horrific. They missed my connecting flight to San Diego. I didn’t get there until Monday at 9am when I had a mandatory court settlement conference scheduled at 6am since we had parties on the east coast. This caused many issues. All because United apparently forgot to hold the doors open until my flight landed that only had a 10 minute delay. This was the last flight to Southern California. So I couldn’t even rent a car to finish the trip. United cannot be trusted when traveling on specific days and times since weather didn’t have anything to do with the delays.

Was a pain having to leave the plane and reboard but glad the plane was fixed

Connecting flights were poor,especially in Naples.our Lufthansa air bus was a joke.way too small for that long of a flight.no room at all.couldn’t even get out of the seats to move around or go to the bathrooms.we thought we were getting an actual air bus,double decker.i will never fly that long in a plane like that again.kind of misleading to call it an air bus.we actually had more room on our buses that we used.

For a 22 minute flight all you expect is for it to be safe and comfortable

Lost connnection had to stayON in Chicago Was a mess

Booked economy through United - air canada treated it as standby and was almost refused boarding.

Traveling to a place near San Diego?

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Everything you need to know for your flight to San Diego

Information on the airport you'll fly into in San Diego