$335 Find Cheap Flights from San Francisco to Panama - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from San Francisco to Panama departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Cheap Flights from San Francisco to Panama

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Panama City
Panama City3 stops$705
Bocas del Toro
Bocas del Toro1 stop$1,008
David
David2 stops$1,206
Panama City
Panama City3 stops$705
Bocas del Toro
Bocas del Toro1 stop$1,008
David
David2 stops$1,206

Book Cheap San Francisco to Panama Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from San Francisco to Panama that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from San Francisco to Panama

Wed, Aug 19 - Tue, Aug 25
Multiple Airlines Logo
12:29 am - 12:35 am
SFO
-
PTY
22h 06m
3 stops
Multiple Airlines Logo
5:55 pm - 7:03 pm
PTY
-
SFO
27h 08m
3 stops
$705Multiple Airlines
Wed, Aug 19 - Tue, Aug 25
Multiple Airlines Logo
12:29 am - 7:20 pm
SFO
-
PTY
16h 51m
2 stops
Multiple Airlines Logo
6:34 pm - 7:03 pm
PTY
-
SFO
26h 29m
2 stops
$712Multiple Airlines
Sun, Aug 30 - Wed, Sep 9
Copa Airlines Logo
1:12 am - 10:27 am
SFO
-
PTY
7h 15mnonstop
Copa Airlines Logo
12:38 pm - 6:10 pm
PTY
-
SFO
7h 32mnonstop
$756Copa Airlines
Sat, Sep 12 - Mon, Sep 21
Multiple Airlines Logo
7:17 pm - 4:06 pm
SFO
-
PTY
18h 49m
2 stops
Multiple Airlines Logo
5:30 am - 12:50 pm
PTY
-
SFO
9h 20m
1 stop
$761Multiple Airlines
Sun, Sep 13 - Mon, Sep 21
Multiple Airlines Logo
10:48 pm - 8:30 am
SFO
-
PTY
31h 42m
2 stops
Multiple Airlines Logo
5:30 am - 12:50 pm
PTY
-
SFO
9h 20m
1 stop
$762Multiple Airlines
Mon, Aug 24 - Mon, Aug 31
Multiple Airlines Logo
10:35 pm - 7:20 pm
SFO
-
PTY
18h 45m
2 stops
Multiple Airlines Logo
5:30 am - 12:50 pm
PTY
-
SFO
9h 20m
1 stop
$768Multiple Airlines
Fri, Sep 4 - Tue, Sep 8
United Airlines Logo
6:30 pm - 2:14 pm
SFO
-
PTY
17h 44m
1 stop
United Airlines Logo
3:30 pm - 9:30 am
PTY
-
SFO
20h 00m
1 stop
$771United Airlines
Mon, Aug 31 - Wed, Sep 9
American Airlines Logo
2:08 pm - 12:39 pm
SFO
-
PTY
20h 31m
2 stops
American Airlines Logo
1:16 pm - 11:59 pm
PTY
-
SFO
12h 43m
1 stop
$775American Airlines
Tue, Aug 25 - Thu, Aug 27
American Airlines Logo
9:35 pm - 12:39 pm
SFO
-
PTY
13h 04m
1 stop
American Airlines Logo
1:39 pm - 12:11 am
PTY
-
SFO
12h 32m
2 stops
$777American Airlines
Mon, Aug 24 - Fri, Aug 28
United Airlines Logo
4:40 pm - 9:08 am
SFO
-
DAV
38h 28m
2 stops
United Airlines Logo
9:50 am - 9:30 am
DAV
-
SFO
25h 40m
2 stops
$1,206United Airlines
Booking Insights

KAYAK's insights & trends for San Francisco to Panama flights

Get data-powered insights and trends into flights from San Francisco to Panama to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest San Francisco to Panama flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to Panama from San Francisco found in the last 5 days was to Panama City, at $507 round-trip. The most popular route is from San Francisco (SFO) to Panama City (PTY), and the cheapest round-trip airline ticket found on this route in the last 5 days was $507.

What is the cheapest time of day to fly to Panama?

The average price for all round-trip flights from San Francisco to Panama depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to Panama is generally in the morning, when round-trip flights cost $709 on average. The most expensive time of day to fly to Panama is generally at night, which is peak travel time and where the average cost of a ticket is $718.

Can I save money by flying with a layover from San Francisco to Panama?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $917, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from San Francisco to Panama?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from San Francisco to Panama, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from San Francisco to Panama is October, when tickets cost $207 (return) on average. On the other hand, the most expensive months are July and August, when the average cost of round-trip tickets is $418 and $378 respectively.

What’s the cheapest day of the week to fly from San Francisco to Panama?

The average price of all round-trip flights from San Francisco to Panama clicked on KAYAK for each day over the last 12 months.

For San Francisco to Panama, Monday is the cheapest day to fly on average and Saturday is the most expensive. Flying from Panama back to San Francisco, the best deals are generally found on Friday, with Sunday being the most expensive.

How far in advance should I book a flight from San Francisco to Panama?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from San Francisco to Panama, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from San Francisco to Panama, you should book around 7 weeks before departure, which saves you about 17% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 22 weeks before departure.

Good to know

Low seasonSeptember
Cheapest flight$335
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 25% increase in price.
Flight from San Francisco to Panama City

FAQs - booking Panama flights

  • How does KAYAK find such low prices on flights from San Francisco to Panama?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from San Francisco to Panama.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from San Francisco to Panama?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from San Francisco to Panama is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from San Francisco to Panama?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from San Francisco to Panama with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from San Francisco to Panama?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from San Francisco to Panama up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from San Francisco to Panama

 
Need help choosing which airline to fly with from San Francisco to Panama? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1566 reviews
6.9Food
7.8Boarding
7.4Comfort
6.8Entertainment
8.1Crew
Airline reviews

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

2.0 MediocreAnonymous, Dec 2025
LAS - PTY
Read more Copa Airlines reviews

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

It would have been better if they don't separate families in seating. We were seated in the aile row in the middle of a family of four. It would have been better if they they seat the family of four together than separated.

It was good, plane is a bit older so seats are somewhat flat

Very good flight and crew Food was a surprise on a short flight

Biggest issue was that they only had two restrooms in the back of the aircraft. Too many people for only two restrooms. The trash was overflowing and there was paper on the floor too. Long lines in the isle to use it. Food was also a bit meh. They don’t offer snacks with drinks, so you might want to buy a snack to hold you off on a longer trip, since the meals are very small.

Everything was smooth and crew was very polite and friendly.

I like that they served a mail, I’m not sure about the in-flight entertainment. I didn’t really check. staff helped me with my luggage. Smooth boarding smooth takeoff smooth flight

The seats had plenty of leg room and the staff were very nice.

Copa performed as expected for the amount of money I was willing to spend for the flight; it wasn’t exceptional but it was not bad in any way either. The crew was good; friendly and straightforward. The food was airplane food, so no expectations there and the entertainment was lacking but that was my fault for owning an IPhone with a charging port that’s not compatible with the rest of the world. I’d fly Copa again.

Left my bags in origin city on a business class ticket , spent about 2-3 days in the same clothes plus the flight .

Excellent communication from the staff. We actually arrived early. Very friendly and professional staff.

No extra snacks were available. Meals quality is terrible. Crew was not friendly.

Lost one piece of luggage even though I checked in 2.5 hours before the flight

It was perfect! United Airlines staff was extremely caring, super friendly and professional

United has maintenance issues and can then never recover. No operations ability and simple issues always turn into multiple hours long cascading delays. Worst airline on earth.

I paid for a confirmed upgraded aisle seat and was moved to a center seat in the back of the plane at the last minute.

Horrifying Almost 2 million miles. Bring your own food and drink. One coffee or drink every three hours. Have to order meals on app more than 24 hours ahead Tiny and dirty bathrooms

Easy of boarding, helpfully staff at check in, surprisingly comfortable seating

Lost of requested seat assignments. Lost my husband's meal choice

Same as last comment. Food sucks. Quality. Not surprising most people have no clue about nourishment Clearly

The plane was spartan, the seats not that comfortable. It was like flying a super low budget airline. They charged for coffee!!! I have never, ever experienced that before.

I had no problems but the changing of planes that I was supposed to be on was confusing. Maybe it would be helpful to let people know your flight changed. Not everyone understands airports or how flying works.

Flight was delayed multiple times without giving any particular reason and the only thing that was communicated was that 'Aircraft is getting ready'. I was stuck at SFO airport for 15 hours and finally took Southwest Airlines flight back home to Dallas.

I was not clear if food was offered or not.

Agency very bad had to cancelled my booking too many changes in the flight changed my flight to 1 week

Take-off delayed an hour because of a missing flight officer, so,arrived in Charlotte lates causing many passengers to miss connections. Otherwise a very good flight, safe and comfortable, with an excellent professional crew.

B-class on an old plane with antiquated amenities and poor service. Landed in Rome w/o bag that didn’t make the connection (plenty of time in London). Bag will come to hotel NOT the day it lands but the following night!! Still waiting for bag…BA had nothing to offer in support and couldn’t even tell me their comp, told to submit receipts and then I’ll learn what is or isn’t covered.

Premium Economy Good crew, good service, excellent food. Seat back screen just not bright enough.

The SFO Lounge crew were amazing. The bartender Faris was great. Thanks!

Not good. One of my luggage is missing. And until now they can’t find it

Staff are the rudest in the industry … awful customer service … will never fly Avianca again

Here we have another airline flying to Guatemala but doesn't have a plus or a less, just in the middle. Why? Well, first we don't have even free water Movie selection is poor Seats don't recline in some places Food selection is carb based Forgot to mention, customer service on the web is the worst. Good things; Very reliable on schedule Kind crew

I had to go to the boarding counter for them to enter my return flight as it’s not with Avianca. There was a long queue as there were lots of people being called to the counter.

Boarding, crew were excellent, food was ok and entertainment need to improve

There isn't much space in-between seats and even water needs to be paid for during the flight.

We were not aware carry-on bags cost extra until we arrived at the airport so, we were charged $240.00 for two small carry- on bags! There was a substantial fee for drinks and snacks. No wifi, or other entertainment was available. Waiting areas were crowded and uncomfortable.

Ok, but these people don’t give you nothing no snack no water

No water for a 5 hour flight entertainment not working seats with little room for knees when person in front of me reclined kept bumping my knees.

Awful. I checked in online and there was no option to pay for baggage, at the airport when I checked in my baggage was received and Iwas not charged. When I got to LA during the boarding process I was told I didn't pay for baggage, the crew resolved I was let in the plane. When I got to my final destination my baggage was not there. It took me two days to receive my baggage. Bad service ever!

Wasn’t able to take the trip and no one could help me with a refund or rescheduling

Everything you need to know for your flight from San Francisco to Panama

Information on your arrival and departure airports