$336 Find Cheap Flights from Panama to San Francisco - Compare and Save

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Cheap Flights from Panama to San Francisco

 

Cheap flights to San Francisco from top airlines, updated regularly. Compare round-trip, one-way, direct and last-minute deals.

Thu, Oct 22 - Sat, Oct 31
Avianca Logo
10:10 am - 10:35 pmPTY  Panama City Tocumen Intl-SFO San Francisco
14h 25m2 stops Bogotá El Dorado San Salvador El Salvador Intl
Avianca Logo
2:15 pm - 2:10 amSFO  San Francisco-PTY Panama City Tocumen Intl
9h 55m1 stop San Salvador El Salvador Intl
$691Avianca
Fri, Oct 30 - Mon, Nov 9
Avianca Logo
5:30 am - 12:55 pmPTY  Panama City Tocumen Intl-SFO San Francisco
9h 25m1 stop San Salvador El Salvador Intl
Avianca Logo
11:00 pm - 5:15 pmSFO  San Francisco-PTY Panama City Tocumen Intl
15h 15m2 stops San Salvador El Salvador Intl Bogotá El Dorado
$691Avianca
Wed, Dec 2 - Tue, Dec 8
Avianca Logo
5:30 am - 11:55 amPTY  Panama City Tocumen Intl-SFO San Francisco
9h 25m1 stop San Salvador El Salvador Intl
Avianca Logo
1:15 pm - 2:10 amSFO  San Francisco-PTY Panama City Tocumen Intl
9h 55m1 stop San Salvador El Salvador Intl
$691Avianca
Wed, Feb 3 - Wed, Feb 17
American Airlines Logo
2:26 pm - 11:59 pmPTY  Panama City Tocumen Intl-SFO San Francisco
12h 33m1 stop Miami
American Airlines Logo
9:35 pm - 3:30 pmSFO  San Francisco-PTY Panama City Tocumen Intl
14h 55m1 stop Miami
$705American Airlines
Mon, Nov 16 - Sun, Nov 29
Copa Airlines Logo
6:31 pm - 11:12 pmPTY  Panama City Tocumen Intl-SFO San Francisco
7h 41mnonstop
Copa Airlines Logo
12:33 am - 10:46 amSFO  San Francisco-PTY Panama City Tocumen Intl
7h 13mnonstop
$708Copa Airlines
Fri, Nov 20 - Sun, Nov 22
Copa Airlines Logo
6:31 pm - 11:12 pmPTY  Panama City Tocumen Intl-SFO San Francisco
7h 41mnonstop
Copa Airlines Logo
12:33 am - 10:46 amSFO  San Francisco-PTY Panama City Tocumen Intl
7h 13mnonstop
$708Copa Airlines
Wed, Feb 3 - Wed, Feb 17
American Airlines Logo
2:26 pm - 8:56 amPTY  Panama City Tocumen Intl-SFO San Francisco
21h 30m2 stops Miami Dallas/Fort Worth
American Airlines Logo
9:35 pm - 1:47 pmSFO  San Francisco-PTY Panama City Tocumen Intl
13h 12m1 stop Miami
$709American Airlines
Wed, Feb 3 - Wed, Feb 17
American Airlines Logo
2:26 pm - 9:29 amPTY  Panama City Tocumen Intl-SFO San Francisco
22h 03m2 stops Miami Chicago O'Hare Intl
American Airlines Logo
7:08 pm - 3:30 pmSFO  San Francisco-PTY Panama City Tocumen Intl
17h 22m2 stops Phoenix Sky Harbor Intl Miami
$709American Airlines
Tue, Dec 1 - Wed, Dec 9
United Airlines Logo
4:41 pm - 5:07 pmPTY  Panama City Tocumen Intl-SFO San Francisco
27h 26m1 stop Houston George Bush Intcntl
United Airlines Logo
12:15 am - 5:12 pmSFO  San Francisco-PTY Panama City Tocumen Intl
13h 57m1 stop Houston George Bush Intcntl
$714United Airlines
Thu, Nov 5 - Sat, Nov 7
United Airlines Logo
8:55 am - 6:45 pmPTY  Panama City Tocumen Intl-SFO San Francisco
12h 50m1 stop Houston George Bush Intcntl
United Airlines Logo
6:35 pm - 2:45 pmSFO  San Francisco-PTY Panama City Tocumen Intl
17h 10m1 stop Houston George Bush Intcntl
$714United Airlines

KAYAK's insights & trends for flights to San Francisco

Get data-powered insights and trends for flights to San Francisco to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest day to fly to San Francisco?

Based on KAYAK data, the cheapest day to fly to San Francisco is Wednesday where round-trip tickets can be as cheap as $562. On the other hand, the most expensive day to fly is Sunday, where round-trip prices are $1,252 on average.

What is the cheapest month to fly to San Francisco?

The cheapest month for flights to San Francisco is April, where tickets cost $624 on average for return flights. On the other hand, the most expensive months are October and November, where the average cost of tickets from Panama is $866 and $819 respectively. For one-way flights, the best month to travel is May with an average price of $311.

What is the cheapest time of day to fly to San Francisco?

The cheapest time of day to fly to San Francisco is generally in the morning, when round-trip flights cost $752 on average. The most expensive time of day to fly to San Francisco is generally in the evening, which is peak travel time and where the average cost of a ticket is $802.

What is a good deal for flights to San Francisco?

If you’re looking for cheap airfare to San Francisco, 25% of our users found tickets to San Francisco for the following prices or less: From Panama City $685 round-trip.

How far in advance should I book a flight to San Francisco?

To get a below average price, you should book around 6 weeks before departure, which saves you about 22% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 24 weeks before departure.

Good to know

Low season

January

Cheapest flight

$336
Best time to beat the crowds with an average 11% drop in price.
Most popular time to fly with an average 1% increase in price.
Flight from Panama City to San Francisco

FAQs - booking San Francisco flights

  • How far is San Francisco Airport from central San Francisco?

    You’ll need to travel 11 miles to reach the San Francisco city center from San Francisco Airport.

  • What is the name of San Francisco’s airport?

    San Francisco is served by San Francisco Airport, also commonly referred to as San Francisco or San Francisco Intl. The airport code is SFO.

  • How much is a flight to San Francisco?

    On average, a flight to San Francisco costs $726. The cheapest price found on KAYAK in the last 2 weeks cost $356 and departed from Panama City Tocumen Intl Airport.

  • How does KAYAK find such low prices on flights to San Francisco?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights to San Francisco.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket to San Francisco?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to San Francisco is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights to San Francisco?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to San Francisco with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight to San Francisco?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to San Francisco up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to San Francisco

  • Looking for cheap airfare to San Francisco? 25% of our users found round-trip tickets to San Francisco for the following prices or less: From Panama City $630

  • Enter your preferred departure airport and travel dates into the search form above to unlock the latest San Francisco flight deals.

Reviews of the top 3 airlines serving from Panama to San Francisco

 
Need help choosing which airline to fly with to San Francisco? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1548 reviews
6.9Entertainment
8.1Crew
6.9Food
7.8Boarding
7.4Comfort
Airline reviews

We were made to check our carry-on luggage because it did not fit the measurements. That’s what we were told, but I saw plenty of carry-on luggage on the plane that was the same size as ours

4.0 OkayAnonymous, Sep 2026
Read more Copa Airlines reviews

We were made to check our carry-on luggage because it did not fit the measurements. That’s what we were told, but I saw plenty of carry-on luggage on the plane that was the same size as ours

Flight Crew Review The crew was absolutely amazing from start to finish! They were friendly, professional, attentive, and genuinely made the flight feel comfortable and enjoyable. Every interaction was pleasant, and they went above and beyond to make sure passengers were taken care of. You could really tell that they cared about providing great service. I truly appreciate their kindness and professionalism and would be happy to fly with this crew again!

stood in line to check in luggage for nearly an hour. very poor service and not excusable

Same as the previous flight as far as comfort and food. Entertainment didn’t have a watchable screen so everything would need to be watched on your own device in which they didn’t have a charging port that accommodated my iPhone. Seats were very uncomfortable. Staff was very friendly.

Do not book it’s a scam! They stole $1200 from me

Flight got delayed; had to go through security three times.

Had to go through security at the gate again. Had to take off shoes and go through the whole thing again even though we have global entry. They asked us to check in items bought at duty free during our layover and since we checked our luggage at the original departure airport, they forced us to check in a small backpack. None of this ever happened with other airlines. In addition, no vegetarian food option and no snacks during a 7 hr flight. Luggage limits are unusually small. This is unacceptable. Will NEVER fly Copa again and will tell friends and family to avoid this airline.

I upgraded myself to Business Class at the last minute so I had a DREAMS window seat. Seeing as I've never flown Business before everything was novel and fun for me and it made the 7 hour flight much more enjoyable for sure.

Horrible food. No wine or any other alcohol is served on the flight. Water is not served often and they refused when I asked for water in two cups. On the other hand, both going and coming back flights were on time.

it was great! Boarded on-time, reasonable leg room, pleasant staff, decent food. The only thing is we were directed to Terminal 2 when the gate was actually in Terminal 1. Smooth ride. Landed early. Got off plane easily and quickly.

The flight was for my mom in wheelchair the staff in Newark wer not friendly took a long time to even get a wheelchair she almost missed her flight because they finally got a chair few minutes before boarding they had to rush her to the gate. They took her carryon and checked it as a bag told her don’t worry free of charge but they charge the credit card anyway. She also told me the seats are not comfortable at all as if they were broken she could feel the bars in the seat SFO staff was much better overall she had the worst experience

First class flight crew was barely available. They came through 3 times while we were on the plane for nearly 4 hours.

United did nit provide any updated on flight crew not bein available until boarding time started. It was bad. Itws alate night flight and there no proactive communication and iha d an important meeting that i missed due to thus

Delayed too much. 1.5 hrs in the airport and another 1 hr in the runway. Got too late in the night. There was no proper food available.

For the Singapore to CA flight, nearly 16 hours long was miserable. We sat on the tarmac for one hour to burn fuel. The flight attendant girls were mean. They would yell at people who stood up to try to stretch their legs. One time the drinks came thru and the lady judged us and made a comment about how much sugar was in apple juice when we ordered it once. She was rude and inappropriate. The entire flight was frustrating. You'd think a long haul like that the airline would try to make you comfortable. I just don't understand why the ladies were so snappy. I have never experienced rude flight attendants like that. It was the longest flight I've had to sit on before. We were not impressed. Raymond on the other hand was amazing! By far the best person working that flight!

premium economy is expensive but worth it for the comfort and food on a long flight

Even though the incoming flight was delayed by 20 minutes they managed to get us to SFO 15 minutes early.

Boarding, time to take off, in flight offerings, and staff were all great. I recommend using UA for this short flight.

Good experience. Staff was friendly and helpful. Flight was slightly delayed due to airport construction, but they still arrived on time.

This is the worst airline I’ve ever been on in my life and I’ve been probably on 75% of them. I said 15 years ago I would never go on United again. I was an idiot. I booked a flight with them from Las Vegas to San Francisco and of course they screwed that up and cost me a day flying all over the world trying to get to Thailand. My luggage was gone for 35 hours all because they couldn’t make their route on time

It’s a new plane, but the most important detail is that the economy class seat doesn't recline—it’s completely fixed. The only one that reclines is in Comfort Class.

Better seats, allow us to upgrade, terrible website, poor telephone service, better equipment

It was horrible. My experience with Avianca. I didn’t know it was Pakistan international Airlines but anyway, whatever it is it is bad horrible you guys need to upgrade everything in those planes. And you guys charge $130 for a carry-on did they wanna let me in with my carry-on that I travel everywhere with the luggage you guys are such a dog thank you

The fees for baggage were outrageous. $130 for carry on and $150 for check in for an international flight. The seats did not recline. We were not even offered water. Had we known all of this, we would not have booked Avianca at all.

I was shocked flying to El Salvador that they only give you water. Everything else you have to pay for. There is no wifi or entertainment and it’s an international flight. At least back in the day they had tvs on the plane and everyone watched the same movie. Also seats do not recline, even comfort or plus.

I did not like anything, first time I use company and for sure it will be the last time, they charge for simple operations that any other average airline wouldn't charge.

The good thing is the flight was on time and the crew was really nice. They can work better the arriving with staff

The inflight entertainment did not work on a 6 hour flight The cel phone chargers did not work There was a 45 minute wait for the luggage to get off the plane.

They could offer free food and drink like other international flights.

Flight attendants to show up on time, offer drinks and food.

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