$399 Find Cheap Flights from San Luis Obispo to Knoxville - Compare and Save

Only Economy Class is available on flights from San Luis Obispo to Knoxville.

A nonstop flight from San Luis Obispo to Knoxville takes 00m, covering 2,048 miles.

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Round-trip flights from San Luis Obispo to Knoxville range from $398 to $724, with an average of $563 over the past 12 months. Anything below $398 counts as a good deal.

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $399 to $2,103. That means the highest observed fare was about 5x higher than the lowest one.

Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $82 for economy cars. Top options include:

• Budget
• Alamo
• Enterprise Rent-A-Car
• Thrifty
• Avis

Flights from San Luis Obispo to Knoxville usually depart from San Luis Obispo County (SBP) and arrive at Knoxville McGhee Tyson (TYS).

Connecting flights from San Luis Obispo to Knoxville most commonly pass through:

• Dallas/Fort Worth (DFW) - 61% of one-stop connections
• Denver Intl (DEN) - 39% of one-stop connections

Yes. Flexible dates can save you up to 60% on flights from San Luis Obispo to Knoxville. Monday is the cheapest departure day at $314 round-trip on average, while Friday is the most expensive at $772, a difference of $458.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

Flying via Denver Intl (DEN) gives the shortest average 1-stop total travel time at 7h 24m, compared with 8h 18m via Dallas/Fort Worth (DFW).

Knoxville is 3 hours ahead of San Luis Obispo (Eastern Time vs Pacific Time). Plan for the time shift when scheduling connections or first-day activities.