SCL - MDE

$171 Find Cheap Flights from Santiago to Medellín

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santiago to Medellín departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Medellín Jose Maria Cordova Intl Airport

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santiago to Medellín, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santiago to Medellín, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$321
Typical prices: $320-$407
JetSMART
Fri 5/1Fri 5/29
SCL - MDE • 1 stop
Cheapest non-stop
$329
Typical prices: $283-$339
JetSMART
Thu 3/26Fri 4/17
SCL - MDE • Non-stop
Our travelers' advice
AI-powered summary based on content written by travel experts. AI can make mistakes.
Avianca's Classic fare includes a carry-on and checked bag.
JetSMART's low-cost fares include only a small handbag.
Expert advice
Expert advice
Expert advice
Expert advice
When to book
7 weeks
in advance
Our data shows that travelers who book at least 7 weeks in advance save around 21% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
March
Cheapest • 10% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Medellín!
Flight Deals
Booking Insights
Expert advice
Flight Deals

Cheap Flights from Santiago to Medellín (SCL-MDE)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santiago to Medellín that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santiago to Medellín

Fri, May 1 - Fri, May 29
JetSMART Logo
3:30 pm - 11:02 pm
SCL
-
MDE
8h 32m
1 stop
JetSMART Logo
6:05 am - 4:17 am
MDE
-
SCL
21h 12m
1 stop
$321JetSMART
Thu, May 28 - Tue, Jun 2
JetSMART Logo
1:11 am - 6:35 am
SCL
-
MDE
6h 24mnonstop
JetSMART Logo
5:35 pm - 7:46 pm
MDE
-
SCL
25h 11m
1 stop
$326JetSMART
Sat, Feb 28 - Wed, Apr 15
JetSMART Logo
8:13 pm - 6:32 am
SCL
-
MDE
12h 19m
1 stop
JetSMART Logo
6:10 pm - 4:17 am
MDE
-
SCL
9h 07m
1 stop
$329JetSMART
Fri, May 29 - Tue, Jun 2
JetSMART Logo
3:30 pm - 11:02 pm
SCL
-
MDE
8h 32m
1 stop
JetSMART Logo
5:35 pm - 3:56 am
MDE
-
SCL
9h 21m
1 stop
$330JetSMART
Thu, Mar 26 - Fri, Apr 17
JetSMART Logo
2:09 am - 6:24 am
SCL
-
MDE
6h 15mnonstop
JetSMART Logo
5:01 pm - 12:11 am
MDE
-
SCL
6h 10mnonstop
$331JetSMART
Mon, May 11 - Fri, May 22
JetSMART Logo
3:30 pm - 2:09 pm
SCL
-
MDE
23h 39m
1 stop
JetSMART Logo
3:11 pm - 4:17 am
MDE
-
SCL
12h 06m
1 stop
$332JetSMART
Fri, Feb 27 - Wed, Apr 15
JetSMART Logo
2:09 am - 6:24 am
SCL
-
MDE
6h 15mnonstop
JetSMART Logo
6:10 pm - 4:17 am
MDE
-
SCL
9h 07m
1 stop
$333JetSMART
Mon, Feb 16 - Sun, Mar 22
JetSMART Logo
3:37 pm - 3:25 pm
SCL
-
MDE
25h 48m
1 stop
JetSMART Logo
6:27 am - 4:17 am
MDE
-
SCL
19h 50m
1 stop
$336JetSMART
Fri, Mar 13 - Sat, Mar 21
JetSMART Logo
3:37 pm - 4:50 pm
SCL
-
MDE
27h 13m
1 stop
JetSMART Logo
3:03 pm - 9:07 am
MDE
-
SCL
16h 04m
1 stop
$338JetSMART
Mon, Feb 23 - Sun, Mar 15
JetSMART Logo
3:37 pm - 3:25 pm
SCL
-
MDE
25h 48m
1 stop
JetSMART Logo
3:25 pm - 4:17 am
MDE
-
SCL
10h 52m
1 stop
$344JetSMART
Booking Insights

KAYAK's insights & trends for Santiago to Medellín flights

Get data-powered insights and trends into flights from Santiago to Medellín to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Santiago to Medellín Jose Maria Cordova Intl Airport?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Santiago to Medellín Jose Maria Cordova Intl Airport departing in May.

What’s the cheapest day of the week to fly from Santiago to Medellín?

The average price of all round-trip flights from Santiago to Medellín Jose Maria Cordova Intl Airport clicked on KAYAK for each day over the last 12 months.

Your flight ticket price will generally be cheaper if you fly to Medellín on a Sunday and more expensive on a Thursday. On your return trip to Santiago, you should consider flying back on a Wednesday, and avoid Fridays for better deals.

What is the cheapest month to fly from Santiago to Medellín Jose Maria Cordova Intl Airport?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santiago to Medellín Jose Maria Cordova Intl Airport, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santiago to Medellín Jose Maria Cordova Intl Airport is March, where tickets cost $337 (return) on average. On the other hand, the most expensive months are January and December, where the average cost of round-trip tickets is $431 and $393 respectively.

Can I save money by flying with a layover from Santiago to Medellín Jose Maria Cordova Intl Airport?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

Yes, flying with a layover may cost you more time, but you can also save money on the route, with a 1 stop layover the cheapest option at $573 on average.

How far in advance should I book a flight from Santiago to Medellín Jose Maria Cordova Intl Airport?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Santiago to Medellín Jose Maria Cordova Intl Airport, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Santiago to Medellín Jose Maria Cordova Intl Airport, you should book around 7 weeks before departure, which saves you about 21% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 19 weeks before departure.

Expert advice

Expert advice for your flight from Santiago to Medellín

 
AI-powered summary based on content written by travel experts. AI can make mistakes.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Airlines
JetSMART

JetSMART offers low-cost fares with a small handbag included; extras cost more.


Print your boarding pass in advance to avoid airport fees.

Avianca

Avianca's Classic fare includes a carry-on, personal item, and checked bag.


Avianca offers lounge access with Business fares, including showers and workspaces.

Our travel experts
Daniel Scheffler

Daniel Scheffler

Expert on JetSMART

Daniel Scheffler

Daniel Scheffler

Daniel Scheffler is a travel writer, podcaster, and producer. Born in Africa, bred in Europe and now living in America he has traveled to 140 countries (and all 50 U.S. states). Plus he has stayed at over 2500 hotels across the globe. His original shows Everywhere and Without Maps (available on Spotify) showcase his beliefs, travel is about humanity and sharing that beauty. And thus it reminds you that you shouldn’t believe everything you think.

Read more
Mark Chesnut

Mark Chesnut

Expert on Avianca

Mark Chesnut

Mark Chesnut

Mark Chesnut is a travel writer and public speaker with more than 30 years of experience. The 2019 winner of the NLGJA Excellence in Travel Writing Award, Mark is the author of the book “Prepare for Departure” and has covered air travel for multiple top consumer and trade media outlets.

Read more

Good to know

Low seasonSeptember
Cheapest flight$171
Best time to beat the crowds with an average 1% drop in price.
Most popular time to fly with an average 5% increase in price.
Flight from Santiago to Medellín

When to book flights from Santiago to Medellín

Are your dates flexible? Find out the best times to travel from Santiago to Medellín based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking Santiago to Medellín flights

  • What is the cheapest flight from Santiago to Medellín Jose Maria Cordova Intl Airport?

    In the last 3 days, the lowest price for a flight from Santiago to Medellín Jose Maria Cordova Intl Airport was $171 for a one-way ticket and $321 for a round-trip.

  • Do I need a passport to fly between Santiago and Medellín?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Santiago and on arrival in Medellín.

  • Which airports will I be using when flying from Santiago to Medellín?

    Santiago airport is called Santiago Arturo Merino Benitez and the only airport in Medellín is Medellín Jose Maria Cordova Intl.

  • Which aircraft models fly most regularly from Santiago to Medellín?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Santiago to Medellín flight route.

  • Which airline alliances offer flights from Santiago to Medellín?

    Star Alliance is the only airline alliance operating flights between Santiago and Medellín.

  • On which days can I fly direct from Santiago to Medellín?

    There are nonstop flights from Santiago to Medellín on a daily basis.

  • Which is the best airline for flights from Santiago to Medellín, LATAM Airlines or JetSMART?

    The two airlines most popular with KAYAK users for flights from Santiago to Medellín are LATAM Airlines and JetSMART. With an average price for the route of $425 and an overall rating of 7.5, LATAM Airlines is the most popular choice. JetSMART is also a great choice for the route, with an average price of $366 and an overall rating of 6.7.

  • How does KAYAK find such low prices on flights from Santiago to Medellín?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santiago to Medellín.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santiago to Medellín?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Medellín from Santiago is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santiago to Medellín?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Medellín with an airline and back to Santiago with another airline. Booking your flights between Santiago and MDE can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santiago to Medellín?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Medellín from Santiago up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Prefer to fly direct from Santiago to Medellín?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Santiago Arturo Merino Benitez to Medellín Jose Maria Cordova Intl.
Find which airlines fly direct from Santiago Arturo Merino Benitez Airport to Medellín Jose Maria Cordova Intl Airport, which days they fly and book direct flights.

Direct departures

Santiago Arturo Merino Benitez to Medellín Jose Maria Cordova Intl

Monday

JetSMART

JetSMART

Tuesday

JetSMART

JetSMART

Wednesday

JetSMART

JetSMART

Thursday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Saturday

JetSMART

JetSMART

Sunday

JetSMART

JetSMART

See more direct flights

Direct returns

Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez

Monday

JetSMART

JetSMART

Tuesday

JetSMART

JetSMART

Wednesday

JetSMART

JetSMART

Thursday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Saturday

JetSMART

JetSMART

Sunday

JetSMART

JetSMART

See more direct flights

Reviews of the top 3 airlines serving from Santiago to Medellín

 
See real verified KAYAK customer reviews for airlines flying from Santiago to Medellín. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santiago to Medellín? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
LATAM AirlinesOverall score based on 1910 reviews
7.0Entertainment
6.7Food
7.6Boarding
7.3Comfort
8.0Crew
Airline reviews

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

2.0 MediocreAnonymous, Jan 2026
LPB - LIM
Read more LATAM Airlines reviews

LATAM’s crews are fine, but God help you if you need any customer service. Their app and website never work, with error after error. Trying to solve anything over the phone is painful, and lastly, the boarding pass LATAM gave me to board the flight with Delta was invalid and I had to purchase an emergency one-way ticket at the last minute to get home.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

Good flight, boarding ok and crew very nice. Flight was not full so I was able to be very comfortable. Blanket and pillow provided with was good as it was very cold during the flight . Food was very good(small snack sandwich and an excellent piece of orange cake). Overall good flight, no complaints.

Poor, the airline was not able to help me move flights.

Check in -- in business took over 30 mins as there was only one attendant. Boarding was also a mess. The seat was too narrow and was not working properly. Food was very bad and the entertainment very poor. Crew was very polite and helpful, in fairness.

The plane broke down at the Lima stopover and they offered to put me on a flight the be t day but I had to be back in LA that morning and so I had to buy another ticket from Avianca and United for $2k I asked LATAM for compensation and received none. Very bad experience

Really bad experience – delayed for 6 hours without any notice, no food or drinks provided, and stuck in the horrible Cartagena airport.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

My entertainment did not work. I was very tired from the botched connection, and the poor sleep

Our flight was cancelled and it took them 5 hours to reschedule and the next morning they said we still didn’t have a new ticket.

The crew was polite, the Captain specially was cool! But the onboard service was nonexistent: No entertainment, no food, no reclining seats. I know it is a low cost, but the cost of the ticket was not so low for just the transport service.

Was a good flight, no delays and good customer service.

Customer service is horrible. Our flight was at 9pm and we were at check in counter by 7pm. The crew strolls in at 7.30 without even an apology. We were suppose to get our boarding passes online but the website was not working at expected and the staff kept arguing with us saying that is not possible.

There was no entertainment but everyone just used their phones.

The app told us that carry on luggage was included but we were made to pay for it again at the check in counter, making it a very expensive flight. Not happy

I was charged 168 soles for kids stroller. We have travelled across the world and have never charged for the stroller. Horrific airlines and the staff was extremely rude. They wouldn’t let us board unless we pay the extra baggage cost. Never ever flying this airline and I would recommend the same for the others.

Avoid this airline. They are unprofessional. The captain left several passengers on ground due to covid restrictions which were never communicated. As a chilean, I am ashamed that this low level airline comes from my country. Remember this horrible brand and avoid it... Jetsmart

only a bag of chips and a bottle of water in business class was served

Avianca has transitioned from full service legacy airline to "low cost" but has now became a strange hybrid (minimum leg space, started offering business class in domestic flights again, charges passenger for printing boarding pass, etc.). National and international coverage and destinations are really wide but service is not at its best

We found the chairs to be really uncomfortable. It’s also really unacceptable that no form of food or drink is included in a 6+ hour flight

Not good, tried to purchase a first class upgrade and they couldn’t get it done. Was super uncomfortable the whole time.

Deplaning was a mess, I sat in business (seats are horrible) and the front door had a problem so we had to deplane from the rear exit. The stairs were not tall enough to reach so there was a large step down from the plane to the top of the stairs.

Pros: we leave and arrive on time Cons: the most uncomfortable seats ever. You cant recline at all your seats. No entertainment No TVs flight attendants didn't provide even a glass of water. You have to go to back of the airplane and ask for one. I am Colombian and I remember seeing the flight attendants very neat, elegants which is or was a staple of Avianca.it was one with tennis shoes, no male up, the hair was messy... that was really odd.

The flight attendant smashed her beverage cart into my knee, causing significant amount of pain. The seats were extremely uncomfortable. No food or drink is offered unless you want to pay the ridiculous prices for it. The schedule of flying in the overnight hours is also very uncomfortable.

Last seat of Bussines Class it does recline but passenger seating behind kept pushing since they did not have space once my seat was reclined

No free snacks nor drinks on very short 30min flight. Entertainment system is over wifi to your own phone or tablet, which is good but often a show or movie just stops and refuses to continue

I like the crew they're very friendly. I don't like. on five hour flight they not offered snacks. Any drink. Not even coffee

Everything you need to know for your flight from Santiago to Medellín

Information on your arrival and departure airports