MDE - SCL

$222 Find Cheap Flights from Medellín to Santiago - Compare and Save

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Everything you should know

Cheapest round-trip
$327
Typical prices: $376-$495
JetSMART
Mon 11/26Sat 2/3
MDE - SCL • Non-stop
Cheapest one-way
$222
Typical prices: $236-$335
JetSMART
Sun 12/16
MDE - SCL • 1 stop
Nonstop flights
You can fly direct with JetSMART. Average duration is 6h 12m
Direct flights
+1
Direct flights
+1
Avoid delays
Most punctual • 88% on-time
Best time • Fewest delays
Insights
Insights
When to book
in advance
Our data shows that travelers who book at least 18 weeks in advance save around 27% compared to booking last minute.
Insights
Insights
When to travel
Cheapest • 7% price drop
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Cheapest • Avg $412 (round-trip)
Shortest trip • 9h 55m (one-way)
Insights
Insights
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Expert advice
Flight Deals

Cheap Flights from Medellín to Santiago (MDE-SCL)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Medellín to Santiago

Thu, Nov 26 - Wed, Feb 3
JetSMART Logo
4:51 pm - 1:03 amMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
6h 12mnonstop
JetSMART Logo
2:13 am - 6:28 amSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
6h 15mnonstop
$327JetSMART
Thu, Feb 18 - Sat, Feb 20
JetSMART Logo
5:36 pm - 5:03 amMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
9h 27m1 stop Lima J Chavez Intl
JetSMART Logo
2:13 am - 6:28 amSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
6h 15mnonstop
$327JetSMART
Fri, Dec 25 - Thu, Feb 25
JetSMART Logo
5:01 pm - 1:13 amMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
6h 12mnonstop
JetSMART Logo
4:36 pm - 12:32 pmSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
21h 56m1 stop Cali Alfonso B. Aragon Intl
$333JetSMART
Fri, Apr 2 - Sat, Apr 10
Multiple Airlines Logo
5:01 pm - 1:11 amMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
6h 10mnonstop
Multiple Airlines Logo
6:05 am - 11:45 pmSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
18h 40m3 stops Antofagasta Cerro Moreno Cali Alfonso B. Aragon Intl Bogotá El Dorado
$392Multiple Airlines
Wed, Feb 3 - Wed, Mar 17
Multiple Airlines Logo
4:51 pm - 1:03 amMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
6h 12mnonstop
Multiple Airlines Logo
4:36 pm - 11:10 pmSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
8h 34m1 stop Cali Alfonso B. Aragon Intl
$408Multiple Airlines
Thu, Jan 28 - Wed, Mar 17
Multiple Airlines Logo
5:01 pm - 1:13 amMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
6h 12mnonstop
Multiple Airlines Logo
4:36 pm - 11:10 pmSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
8h 34m1 stop Cali Alfonso B. Aragon Intl
$414Multiple Airlines
Tue, Dec 1 - Sun, Dec 20
LATAM Airlines Logo
6:10 pm - 5:20 amMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
9h 10m1 stop Lima J Chavez Intl
LATAM Airlines Logo
7:25 pm - 6:45 pmSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
25h 20m2 stops Quito Mariscal Sucr Bogotá El Dorado
$477LATAM Airlines
Tue, Dec 1 - Sun, Dec 20
LATAM Airlines Logo
2:55 pm - 5:20 amMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
12h 25m2 stops Bogotá El Dorado Lima J Chavez Intl
LATAM Airlines Logo
7:25 pm - 6:45 pmSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
25h 20m2 stops Quito Mariscal Sucr Bogotá El Dorado
$483LATAM Airlines
Fri, Dec 4 - Mon, Apr 5
Copa Airlines Logo
6:25 pm - 5:52 amMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
9h 27m1 stop Panama City Tocumen Intl
Copa Airlines Logo
12:16 am - 3:35 pmSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
16h 19m1 stop Panama City Tocumen Intl
$491Copa Airlines
Sat, Mar 6 - Sat, Mar 6
Copa Airlines Logo
8:45 am - 8:07 pmMDE  Medellín Jose Maria Cordova Intl-SCL Santiago Arturo Merino Benitez
9h 22m1 stop Panama City Tocumen Intl
Copa Airlines Logo
11:58 pm - 7:25 amSCL  Santiago Arturo Merino Benitez-MDE Medellín Jose Maria Cordova Intl
9h 27m1 stop Panama City Tocumen Intl
$517Copa Airlines
Booking Insights

Price, demand and travel trends for Medellín Jose Maria Cordova Intl Airport to Santiago flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Medellín Jose Maria Cordova Intl Airport to Santiago?

Round-trip flights from Medellín Jose Maria Cordova Intl Airport to Santiago typically range from $376 to $495. The lowest price found in the past 5 days was $327, on JetSMART.

What's the cheapest day of the week to fly from Medellín Jose Maria Cordova Intl Airport to Santiago?

Based on deals KAYAK users found in the last 12 months, Thursday is the cheapest day of the week to fly from Medellín Jose Maria Cordova Intl Airport to Santiago. It’s 4% cheaper than the average day, while Saturday is the most expensive, with prices 10% higher.

What’s the cheapest month to fly from Medellín Jose Maria Cordova Intl Airport to Santiago?

•November is the cheapest month to fly from Medellín Jose Maria Cordova Intl Airport to Santiago at $397 round-trip.
•February ($497) and January ($458) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 25% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

When are flights from Medellín Jose Maria Cordova Intl Airport to Santiago the cheapest?

Flights from Medellín Jose Maria Cordova Intl Airport to Santiago are cheapest 18 weeks before departure. Booking in this window typically costs about 27% less than the average last-minute fare (within 2 weeks of the flight), based on KAYAK data.

Expert advice

Expert advice for your flight from Medellín to Santiago

 
KAYAK teamed up with top travel experts to share the best tips for your journey.
Our travel experts
Mark Chesnut

Mark Chesnut

Expert on Avianca

Mark Chesnut is a travel writer and public speaker with more than 30 years of experience. The 2019 winner of the NLGJA Excellence in Travel Writing Award, Mark is the author of the book “Prepare for Departure” and has covered air travel for multiple top consumer and trade media outlets.

Daniel Scheffler

Daniel Scheffler

Expert on JetSMART

Daniel Scheffler is a travel writer, podcaster, and producer. Born in Africa, bred in Europe and now living in America he has traveled to 140 countries (and all 50 U.S. states). Plus he has stayed at over 2500 hotels across the globe. His original shows Everywhere and Without Maps (available on Spotify) showcase his beliefs, travel is about humanity and sharing that beauty. And thus it reminds you that you shouldn’t believe everything you think.

Key details for Medellín Jose Maria Cordova Intl Airport to Santiago flights

Low season

April

Cheapest flight

$222
Beat the crowds with an average 28% drop in travelers.
The most popular month to fly with an average 30% increase in travelers.
One-way flight from Medellín Jose Maria Cordova Intl Airport to Santiago

When to book flights from Medellín to Santiago

Are your dates flexible? Find out the best times to travel from Medellín to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Medellín Jose Maria Cordova Intl Airport to Santiago flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What are the earliest and latest flights from Medellín Jose Maria Cordova Intl Airport to Santiago?

    These are the earliest and latest flight times available from Medellín Jose Maria Cordova Intl Airport to Santiago:

    • Earliest: departs at 4:51 pm and lands at 11:03 pm
    • Latest: departs at 5:31 pm and lands at 11:43 pm.

    The flight takes about 6h 12m.

  • What cabin classes can I book on flights from Medellín Jose Maria Cordova Intl Airport to Santiago?

    Two cabin classes are available on flights from Medellín Jose Maria Cordova Intl Airport to Santiago:

    • Economy Class
    • Business Class

  • How long is a flight from Medellín Jose Maria Cordova Intl Airport to Santiago?

    A nonstop flight from Medellín Jose Maria Cordova Intl Airport to Santiago takes 6h 12m, covering 2,748 miles.

  • Do I need a passport to fly from Medellín Jose Maria Cordova Intl Airport to Santiago?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a Medellín Jose Maria Cordova Intl Airport to Santiago flight?

    Round-trip flights from Medellín Jose Maria Cordova Intl Airport to Santiago range from $376 to $495, with an average of $429 over the past 12 months. Anything below $376 counts as a good deal.

  • How expensive are last-minute Medellín Jose Maria Cordova Intl Airport to Santiago flights?

    Last-minute fares on this route (booked within two weeks of departure) run 20% above the $429 route average. Book 18 weeks before departure for the lowest fares.

  • How much can I save by taking a layover when flying from Medellín Jose Maria Cordova Intl Airport to Santiago?

    On this route, nonstop and layover fares are close on average, with nonstop at $399 round-trip and layover options via Cali Alfonso B. Aragon Intl (CLO) at $412.

  • How does on-time performance compare across airlines flying from Medellín Jose Maria Cordova Intl Airport to Santiago?

    JetSMART is the only airline operating Medellín Jose Maria Cordova Intl Airport to Santiago flights. 88% of its flights are on time.

  • What is the standard checked-bag allowance on flights from Medellín Jose Maria Cordova Intl Airport to Santiago?

    There is no standard. Checked-bag policies vary by airline on this route. Most carriers charge $18–$100 for the first checked bag in economy. Premium fares and elite-status bookings typically include a free checked bag.

  • Which aircraft model is used most often on flights from Medellín Jose Maria Cordova Intl Airport to Santiago?

    The Airbus A320-100/200 family is used most often on this route, operated mainly by JetSMART and LATAM Airlines. Other aircraft seen on the route include Airbus A320 variants.

  • How are flight departures from Medellín Jose Maria Cordova Intl Airport to Santiago spread across the day?

    Evening is the busiest departure period on Medellín Jose Maria Cordova Intl Airport to Santiago flights, with 100% of flights leaving in that window. Morning departures account for 0%, afternoon flights for 0%, and night flights for 0%.

  • Have flight prices from Medellín Jose Maria Cordova Intl Airport to Santiago changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $327 to $1,765. That means the highest observed fare was about 5x higher than the lowest one.

  • How are flight prices from Medellín Jose Maria Cordova Intl Airport to Santiago looking right now?

    One-way fares from Medellín Jose Maria Cordova Intl Airport to Santiago are currently lower than usual. Average one-way flight prices are about $258, which is 9% below the typical average for this route.

  • What car rental options are available at Santiago Arturo Merino Benitez Airport (SCL)?

    Santiago Arturo Merino Benitez Airport (SCL) hosts 5 major car rental companies, with daily rates averaging $36 for economy cars. Top options include:

    • Lucano
    • United Rent-A-Car
    • FlexWays
    • Rosselot
    • Alamo

  • Which airports can I use when flying from Medellín Jose Maria Cordova Intl Airport to Santiago?

    Flights from Medellín Jose Maria Cordova Intl Airport to Santiago usually depart from Medellín Jose Maria Cordova Intl (MDE) and arrive at Santiago Arturo Merino Benitez (SCL).

  • What time of day has the fewest delays on flights from Medellín Jose Maria Cordova Intl Airport to Santiago?

    Afternoon flights have the fewest delays on this route.

  • At what point is a flight considered delayed from Medellín Jose Maria Cordova Intl Airport to Santiago?

    A flight is considered delayed when it departs 15 minutes or more after its scheduled time. This is the standard used by the US Department of Transportation and most airline industry reporting. On the Medellín Jose Maria Cordova Intl Airport to Santiago route, 12% of flights were delayed in the past 3 months, with delays averaging 3h 18m.

  • Which airports do connecting flights from Medellín Jose Maria Cordova Intl Airport to Santiago pass through?

    One-stop flights from Medellín Jose Maria Cordova Intl Airport to Santiago most commonly connect through:

    • Lima J Chavez Intl (LIM) - 31% of one-stop connections
    • Bogotá El Dorado (BOG) - 31% of one-stop connections
    • Panama City Tocumen Intl (PTY) - 30% of one-stop connections
    • Cali Alfonso B. Aragon Intl (CLO) - 8% of one-stop connections

  • Can I save money by using flexible dates for flights from Medellín Jose Maria Cordova Intl Airport to Santiago?

    Yes. Flexible dates can save you up to 14% on flights from Medellín Jose Maria Cordova Intl Airport to Santiago. Thursday is the cheapest departure day at $414 round-trip on average, while Saturday is the most expensive at $476, a difference of $62.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What airlines fly from Medellín Jose Maria Cordova Intl Airport to Santiago?

    Only JetSMART operates flights between Medellín Jose Maria Cordova Intl Airport and Santiago.

  • How much time can I save by choosing a different layover airport from Medellín Jose Maria Cordova Intl Airport to Santiago?

    Flying via Bogotá El Dorado (BOG) gives the shortest average 1-stop total travel time at 9h 55m, compared with 10h 02m via Panama City Tocumen Intl (PTY) and 10h 42m via Lima J Chavez Intl (LIM).

  • What is the time difference between Medellín Jose Maria Cordova Intl Airport and Santiago?

    Santiago is 2 hours ahead of Medellín Jose Maria Cordova Intl Airport (Chile Time vs Colombia Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Santiago?

    Some of the most popular sights in Santiago are Estadio Nacional Julio Martinez Pradanos, Espacio Riesco Convention and Exhibition Center and Costanera Center. These are among the most viewed places in Santiago on KAYAK.

  • Which airlines offer extra legroom and free seat selection on Medellín Jose Maria Cordova Intl Airport to Santiago flights?

    Among airlines operating Medellín Jose Maria Cordova Intl Airport to Santiago flights:

    • JetSMART: offers free seat selection

    Extra legroom and free seat selection availability depends on fare class and route.

  • Which airlines include bags at no extra cost on Medellín Jose Maria Cordova Intl Airport to Santiago flights?

    Here are some options for this route, based on selected ticket types and cabin classes:

    • JetSMART: a cabin bag and a checked bag in Economy Class

    Bag allowance can vary by ticket type, cabin class, route and airline, so always check the fare details before booking.

Your guide to booking Medellín Jose Maria Cordova Intl Airport to Santiago flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Thursday departure and avoid flying on Saturday. On this route, Thursday flights average $414, about $62 less than Saturday fares (13% savings) based on the last 12 months.
  • For the best chance at a low fare, aim to book around 18 weeks before you fly. On this route, that window historically saves about 27% versus last-minute pricing (KAYAK booking data, last 12 months).
  • If you can choose when to travel, plan your Medellín Jose Maria Cordova Intl Airport to Santiago trip for November. Fares historically average $397 round-trip in that month - typically $100 less than the most expensive month, which is February (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Santiago Arturo Merino Benitez Airport.

    • Holiday Inn Santiago - Airport Terminal By IHG

Prefer to fly direct from Medellín to Santiago?

 
Find which airlines fly direct from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport, which days they fly and book direct flights.

Direct departures

Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez

Monday

JetSMART

JetSMART

Tuesday

JetSMART

JetSMART

Wednesday

JetSMART

JetSMART

Thursday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Saturday

JetSMART

JetSMART

Sunday

JetSMART

JetSMART

See more direct flights

Direct returns

Santiago Arturo Merino Benitez to Medellín Jose Maria Cordova Intl

Monday

JetSMART

JetSMART

Tuesday

JetSMART

JetSMART

Wednesday

JetSMART

JetSMART

Thursday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Saturday

JetSMART

JetSMART

Sunday

JetSMART

JetSMART

See more direct flights

More options for your flight from Medellín to Santiago

Complete your trip to Santiago with a hotel stay or car rental