MDE - SCL

$219 Find Cheap Flights from Medellín to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Medellín to Santiago departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medellín to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Medellín to Santiago, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$323
Typical prices: $367-$438
JetSMART
Fri 7/10Mon 7/13
MDE - SCL • Non-stop
Cheapest one-way
$219
Typical prices: $220-$275
JetSMART
Wed 7/22
MDE - SCL • 1 stop
Advice from real travelers
AI-powered summary based on content written by travel experts. AI can make mistakes.
Avianca's Classic fare includes a carry-on and checked bag.
JetSMART's FlySMART fare only includes a small handbag.
Expert advice
Expert advice
Expert advice
Expert advice
Nonstop flights
Mon, Thu, Fri, Sun
You can fly direct with JetSMART. Average duration is 6h 08m
Direct flights
Direct flights
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Direct flights
Direct flights
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Top layover airports
Cheapest • Avg $386 (round-trip)
Shortest trip • 8h 28m (one-way)
Insights
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Insights
Avoid delays
Most punctual • 86% on-time
Best time • Fewest delays
Insights
Insights
Insights
Insights
When to book
in advance
Our data shows that travelers who book at least 10 weeks in advance save around 17% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
Cheapest • 5% price drop
Most popular
Good to know
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santiago!
Flight Deals
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Expert advice
Flight Deals

Cheap Flights from Medellín to Santiago (MDE-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Medellín to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Medellín to Santiago

Fri, Jul 10 - Mon, Jul 13
JetSMART Logo
5:01 pm - 12:11 am
MDE
-
SCL
6h 10mnonstop
JetSMART Logo
1:11 am - 6:35 am
SCL
-
MDE
6h 24mnonstop
$323JetSMART
Thu, Apr 2 - Fri, Apr 17
JetSMART Logo
5:01 pm - 1:11 am
MDE
-
SCL
6h 10mnonstop
JetSMART Logo
3:30 pm - 11:02 pm
SCL
-
MDE
8h 32m
1 stop
$327JetSMART
Mon, Apr 13 - Mon, Apr 20
JetSMART Logo
1:46 pm - 4:17 am
MDE
-
SCL
13h 31m
1 stop
JetSMART Logo
3:30 pm - 11:08 pm
SCL
-
MDE
8h 38m
1 stop
$329JetSMART
Fri, May 15 - Fri, May 22
JetSMART Logo
5:01 pm - 12:11 am
MDE
-
SCL
6h 10mnonstop
JetSMART Logo
1:11 am - 6:35 am
SCL
-
MDE
6h 24mnonstop
$330JetSMART
Sun, May 3 - Wed, May 20
JetSMART Logo
5:01 pm - 12:11 am
MDE
-
SCL
6h 10mnonstop
JetSMART Logo
3:30 pm - 6:31 am
SCL
-
MDE
16h 01m
2 stops
$333JetSMART
Mon, Jun 1 - Thu, Jun 4
JetSMART Logo
5:01 pm - 12:11 am
MDE
-
SCL
6h 10mnonstop
JetSMART Logo
1:11 am - 6:35 am
SCL
-
MDE
6h 24mnonstop
$334JetSMART
Thu, Apr 30 - Sun, May 3
JetSMART Logo
5:01 pm - 12:11 am
MDE
-
SCL
6h 10mnonstop
JetSMART Logo
3:30 pm - 9:56 pm
SCL
-
MDE
55h 26m
2 stops
$335JetSMART
Fri, May 8 - Fri, May 15
JetSMART Logo
5:01 pm - 12:11 am
MDE
-
SCL
6h 10mnonstop
JetSMART Logo
3:30 pm - 6:31 am
SCL
-
MDE
40h 01m
2 stops
$336JetSMART
Mon, Jun 1 - Sun, Jun 14
JetSMART Logo
5:01 pm - 12:11 am
MDE
-
SCL
6h 10mnonstop
JetSMART Logo
1:11 am - 6:35 am
SCL
-
MDE
6h 24mnonstop
$337JetSMART
Mon, Jun 1 - Sun, Jun 14
JetSMART Logo
5:01 pm - 12:11 am
MDE
-
SCL
6h 10mnonstop
JetSMART Logo
1:11 am - 6:35 am
SCL
-
MDE
6h 24mnonstop
$338JetSMART
Booking Insights

KAYAK's insights & trends for Medellín to Santiago flights

Get data-powered insights and trends into flights from Medellín to Santiago to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Medellín Jose Maria Cordova Intl Airport to Santiago?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Medellín Jose Maria Cordova Intl Airport to Santiago departing in July.

What’s the cheapest day of the week to fly from Medellín to Santiago?

The average price of all round-trip flights from Medellín Jose Maria Cordova Intl Airport to Santiago clicked on KAYAK for each day over the last 12 months.

When flying from Medellín to Santiago, you should consider leaving on a Wednesday and avoid Fridays if you are looking for the best rates. For your return to Medellín, you’ll find the best rates on Tuesdays and the most expensive ones on Sundays.

What is the cheapest month to fly from Medellín Jose Maria Cordova Intl Airport to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Medellín Jose Maria Cordova Intl Airport to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Medellín Jose Maria Cordova Intl Airport to Santiago is May, where tickets cost $382 (return) on average. On the other hand, the most expensive months are February and January, where the average cost of round-trip tickets is $479 and $406 respectively.

Can I save money by flying with a layover from Medellín Jose Maria Cordova Intl Airport to Santiago?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $318, prices are generally cheapest when you fly direct.

How far in advance should I book a flight from Medellín Jose Maria Cordova Intl Airport to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Medellín Jose Maria Cordova Intl Airport to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Medellín Jose Maria Cordova Intl Airport to Santiago, you should book around 10 weeks before departure, which saves you about 17% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 19 weeks before departure.

Expert advice

Expert advice for your flight from Medellín to Santiago

 
AI-powered summary based on content written by travel experts. AI can make mistakes.
KAYAK teamed up with top travel experts to share the best tips for your journey.
Our travel experts
Daniel Scheffler

Daniel Scheffler

Expert on JetSMART

Daniel Scheffler is a travel writer, podcaster, and producer. Born in Africa, bred in Europe and now living in America he has traveled to 140 countries (and all 50 U.S. states). Plus he has stayed at over 2500 hotels across the globe. His original shows Everywhere and Without Maps (available on Spotify) showcase his beliefs, travel is about humanity and sharing that beauty. And thus it reminds you that you shouldn’t believe everything you think.

Mark Chesnut

Mark Chesnut

Expert on Avianca

Mark Chesnut is a travel writer and public speaker with more than 30 years of experience. The 2019 winner of the NLGJA Excellence in Travel Writing Award, Mark is the author of the book “Prepare for Departure” and has covered air travel for multiple top consumer and trade media outlets.

Good to know

Low seasonMay
Cheapest flight$219
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 3% lower on average.
Flight from Medellín to Santiago

When to book flights from Medellín to Santiago

Are your dates flexible? Find out the best times to travel from Medellín to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking Medellín to Santiago flights

  • What is the cheapest flight from Medellín Jose Maria Cordova Intl Airport to Santiago?

    In the last 3 days, the lowest price for a flight from Medellín Jose Maria Cordova Intl Airport to Santiago was $219 for a one-way ticket and $323 for a round-trip.

  • Do I need a passport to fly between Medellín and Santiago?

    A passport is required to fly from Medellín to Santiago.

  • Which aircraft models fly most regularly from Medellín to Santiago?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Medellín to Santiago flight route.

  • Which airline alliances offer flights from Medellín to Santiago?

    Star Alliance is the only airline alliance operating flights between Medellín and Santiago.

  • On which days can I fly direct from Medellín to Santiago?

    You can catch a nonstop flight from Medellín to Santiago on Monday, Tuesday, Thursday, Friday, and Sunday.

  • Which is the best airline for flights from Medellín to Santiago, Copa Airlines or LATAM Airlines?

    The two airlines most popular with KAYAK users for flights from Medellín to Santiago are Copa Airlines and LATAM Airlines. With an average price for the route of $441 and an overall rating of 7.5, Copa Airlines is the most popular choice. LATAM Airlines is also a great choice for the route, with an average price of $444 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Medellín to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Medellín to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Medellín to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Medellín is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Medellín to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Medellín with another airline. Booking your flights between Medellín and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Medellín to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Medellín up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Medellín Jose Maria Cordova Intl Airport to Santiago

  • Looking for a cheap flight? 25% of our users found flights on this route for $209 or less one-way.

Prefer to fly direct from Medellín to Santiago?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez.
Find which airlines fly direct from Medellín Jose Maria Cordova Intl Airport to Santiago Arturo Merino Benitez Airport, which days they fly and book direct flights.

Direct departures

Medellín Jose Maria Cordova Intl to Santiago Arturo Merino Benitez

Monday

JetSMART

JetSMART

Thursday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Sunday

JetSMART

JetSMART

See more direct flights

Direct returns

Santiago Arturo Merino Benitez to Medellín Jose Maria Cordova Intl

Monday

JetSMART

JetSMART

Tuesday

JetSMART

JetSMART

Friday

JetSMART

JetSMART

Saturday

JetSMART

JetSMART

See more direct flights

Reviews of the top 4 airlines serving from Medellín to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Medellín to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Medellín to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.5
Copa AirlinesOverall score based on 1569 reviews
8.1Crew
6.8Food
6.8Entertainment
7.4Comfort
7.8Boarding
Airline reviews

Copa staff at PTY and one particular crew member were unhelpful & rude.

6.0 GoodOluwaseyi, Feb 2026
PTY - POS
Read more Copa Airlines reviews

Copa staff at PTY and one particular crew member were unhelpful & rude.

Seats were awful. Media should have been included for such a long flight.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

The flight was good overall. Everything went smoothly, although the landing was a bit rough. Still, it was a pleasant experience

Some of the Air hostesses are not that friendly. Need improvement

I liked the meatloaf the chicken was awful but the plane was on time and got there and the staff was nice.

They were super friendly bumped me up to exit row free of charge, All flight legs were on time

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

Cops Airlines is fantastic! The level of care and professionalism provided by the entire crew was top rate.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

Nothing I like, I missed this connection b/c of an earlier flight delay. I had to stay one more night and I paid out my own pocket. LATAM failed to send me to a safe and decent hotel.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

On board crew was very good. Crew was friendly, snacks were good, especially the chips. Seats seemed a bit cramped. Boarding seemed unorganized, as we were instructed to get to the gate an hour early and then just stood around until boarding.

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

We were not allowed to carry a bottle of water onto the 8 hour flight.

There was a mechanical issue with the plane that they had to work on before we could take off. That's fine, by all means, PLEASE make sure the mechanics are functioning properly. What was a problem was the fact that we sat on the tarmac for 4.5 hours without moving, without letting us off the plane, and without climate control and air running through the plane. There was no explanation as to what was going on; they just kept promising that it would be "15 minutes, then we are on our way." At one point, they even switched the entire crew out and told everyone we just needed to wait for new employees to show up. Then, as the 4 hours were not moving, an hour before the full refund, they made a big show about "the flight starting and the doors are locked, so you have to sit down." We didn't move for another 40 minutes; they were just trying to skirt around legalities that entitled us to restitution. When the flight finally was underway, the plane was gigantic but cramped in design, my entertainment screen kept freezing and glitching, and subtitles didn't work, and the crew was passive-aggressive. Terrible flight.

Comfort in exit seat was excellent. FLight crew and flight were excellent. However exit seat tray table was broken so could not use it. Entertainment monitor did not work at all despite attempts to reset it.

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

The plane broke down at the Lima stopover and they offered to put me on a flight the be t day but I had to be back in LA that morning and so I had to buy another ticket from Avianca and United for $2k I asked LATAM for compensation and received none. Very bad experience

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

First of all, could be Kyak's fault he we couldn't for days check in on line via Kayak or Jet Smart. We can't get the app either. Luckily on LATAM I managed to get the WiFi and contact Jet smart via what's app. This was horrendous and the person was unhelpful to start with. But we explained and she managed to check us in as if she didn't we wouldn't have got on the flight as would've been too late to check in. At the gate they were checking everyone's bag for size. My bag was 1 cm over and they tried to charge me $255 soles to carry it on but was 225 to put it in the hold. We had to pay to put both bags in the hold adding £100 to the cost of the flight. We had to carry the bags as the jet smart sight doesn't allow us to add bags which would've cost us £13 each so £26 on booking instead of £100. Staff at the gate were rude to us and other passengers. I'm sure they were on commission to get money off passengers for the bags. The lady flight attendant was pleasant but over ruled buy this jumped up young guy when I asked if my partner could sit beside me. The plane was 1/3 full. Then he was rude most of the flight. Avoid jet smart at all costs! Worrying thing is we have a return journey with these shower of.... We have been on their site the past two days trying to add bags but site won't do anything. I think this is on purpose to get more money out of passengers. As I said avoid at all costs.

Terrible website. Does not work most of the time I tired using it to check in. Had to have someone from another country help me check in. Their customer service is the worst.

The crew was polite, the Captain specially was cool! But the onboard service was nonexistent: No entertainment, no food, no reclining seats. I know it is a low cost, but the cost of the ticket was not so low for just the transport service.

Was a good flight, no delays and good customer service.

Customer service is horrible. Our flight was at 9pm and we were at check in counter by 7pm. The crew strolls in at 7.30 without even an apology. We were suppose to get our boarding passes online but the website was not working at expected and the staff kept arguing with us saying that is not possible.

There was no entertainment but everyone just used their phones.

The app told us that carry on luggage was included but we were made to pay for it again at the check in counter, making it a very expensive flight. Not happy

I was charged 168 soles for kids stroller. We have travelled across the world and have never charged for the stroller. Horrific airlines and the staff was extremely rude. They wouldn’t let us board unless we pay the extra baggage cost. Never ever flying this airline and I would recommend the same for the others.

Avoid this airline. They are unprofessional. The captain left several passengers on ground due to covid restrictions which were never communicated. As a chilean, I am ashamed that this low level airline comes from my country. Remember this horrible brand and avoid it... Jetsmart

Horrible experience with Avianca, they delayed their flight and when we arrived to NYC, AVIANCA took 1 hr y 30 mins to park the airplane and all passenger get off the plane, it made me lost all my trains to get back home and I came back to my place at 3 am instead of 12 am. On the top of that their plane seat are so uncomfortable and is not enough space and killed my legs and knees, Avianca used to be good when it was a Colombian company, now after Brasilian company bought them, their service quality is bad and their flights are delayed and oversold.

It was delayed and I lost my connection flight to Cali and I missed my Mom's funeral and avianca lost my check in luggage

I upgraded to businesses class. Because of that the flight was comfortable.

Avianca has transitioned from full service legacy airline to "low cost" but has now became a strange hybrid (minimum leg space, started offering business class in domestic flights again, charges passenger for printing boarding pass, etc.). National and international coverage and destinations are really wide but service is not at its best

Provide free food and drinks on an international flight. Add updated head rests

Not good, tried to purchase a first class upgrade and they couldn’t get it done. Was super uncomfortable the whole time.

Boarding was late due to the company’s that cleaned the aircraft (very poorly done) and the catering company. The entertainment system was not working for this six hour flight, uncomfortable seats in business (barely any cushion or recline). The airline staff is very good but the planes are horrible and not well maintained.

I like the crew members they're very friendly. Clean plane. The flight was on time. I dont like the comfort my car seat its better that the plane seats. They charge for everything. This airline was very good. Now it's a low cost airline

No free snacks nor drinks on very short 30min flight. Entertainment system is over wifi to your own phone or tablet, which is good but often a show or movie just stops and refuses to continue

6 hour flight and have to pay for everything 100 dollars to add a carry-on bag is insane

Everything you need to know for your flight from Medellín to Santiago

Information on your arrival and departure airports