SDQ - SCL

$332 Find Cheap Flights from Santo Domingo to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santo Domingo to Santiago departing on 3/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santo Domingo to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santo Domingo to Santiago, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$524
Typical prices: $585-$662
Multiple Airlines
Thu 3/19Wed 3/25
SDQ - SCL • 1 stop
Cheapest one-way
$335
Typical prices: $312-$417
Multiple Airlines
Sun 3/15
SDQ - SCL • 2 stops
When to travel
August
Cheapest • 10% price drop
December
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
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We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santo Domingo to Santiago (SDQ-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santo Domingo to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santo Domingo to Santiago

Thu, Mar 19 - Wed, Mar 25
Multiple Airlines Logo
1:50 pm - 3:35 am
SDQ
-
SCL
12h 45m
1 stop
Multiple Airlines Logo
6:00 am - 4:45 pm
SCL
-
SDQ
11h 45m
1 stop
$524Multiple Airlines
Thu, Apr 2 - Fri, Apr 10
Avianca Logo
11:45 am - 11:30 pm
SDQ
-
SCL
10h 45m
1 stop
Avianca Logo
6:10 am - 5:15 pm
SCL
-
SDQ
11h 05m
1 stop
$608Avianca
Wed, Mar 4 - Wed, Mar 11
Multiple Airlines Logo
5:45 pm - 3:20 pm
SDQ
-
SCL
20h 35m
1 stop
Multiple Airlines Logo
6:00 am - 4:45 pm
SCL
-
SDQ
11h 45m
1 stop
$635Multiple Airlines
Thu, Apr 2 - Fri, Apr 10
Multiple Airlines Logo
11:45 am - 11:30 pm
SDQ
-
SCL
10h 45m
1 stop
Multiple Airlines Logo
3:30 pm - 1:37 pm
SCL
-
SDQ
22h 07m
2 stops
$677Multiple Airlines
Wed, Mar 4 - Wed, Mar 11
Multiple Airlines Logo
5:45 pm - 10:39 am
SDQ
-
SCL
15h 54m
2 stops
Multiple Airlines Logo
6:00 am - 4:45 pm
SCL
-
SDQ
11h 45m
1 stop
$685Multiple Airlines
Wed, Mar 4 - Wed, Mar 11
Multiple Airlines Logo
7:25 pm - 1:58 pm
SDQ
-
SCL
41h 33m
3 stops
Multiple Airlines Logo
4:25 pm - 11:25 am
SCL
-
SDQ
20h 00m
1 stop
$713Multiple Airlines
Fri, Mar 20 - Mon, Mar 23
Copa Airlines Logo
11:56 am - 3:17 am
SDQ
-
SCL
14h 21m
1 stop
Copa Airlines Logo
12:28 pm - 10:40 pm
SCL
-
SDQ
11h 12m
1 stop
$717Copa Airlines
Thu, Apr 2 - Fri, Apr 10
Multiple Airlines Logo
11:45 am - 11:30 pm
SDQ
-
SCL
10h 45m
1 stop
Multiple Airlines Logo
3:30 pm - 1:55 pm
SCL
-
SDQ
22h 25m
3 stops
$720Multiple Airlines
Sun, Feb 1 - Sun, Feb 15
Multiple Airlines Logo
9:26 pm - 3:20 pm
SDQ
-
SCL
40h 54m
2 stops
Multiple Airlines Logo
9:14 pm - 8:42 am
SCL
-
SDQ
12h 28m
1 stop
$728Multiple Airlines
Wed, Mar 4 - Wed, Mar 11
Multiple Airlines Logo
7:25 pm - 1:58 pm
SDQ
-
SCL
41h 33m
3 stops
Multiple Airlines Logo
3:37 pm - 1:50 pm
SCL
-
SDQ
23h 13m
2 stops
$733Multiple Airlines
Booking Insights

KAYAK's insights & trends for Santo Domingo to Santiago flights

Get data-powered insights and trends into flights from Santo Domingo to Santiago to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Santo Domingo to Santiago?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Santo Domingo to Santiago departing in March.

What is the cheapest month to fly from Santo Domingo to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santo Domingo to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santo Domingo to Santiago is August, where tickets cost $578 (return) on average. On the other hand, the most expensive months are February and January, where the average cost of round-trip tickets is $856 and $767 respectively.

Can I save money by flying with a layover from Santo Domingo to Santiago?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $575, prices are generally cheapest when you fly direct.

How far in advance should I book a flight from Santo Domingo to Santiago?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Santo Domingo to Santiago, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Santo Domingo to Santiago, you should book around 1 week before departure. For the absolute cheapest price, our data suggests you should book 18 weeks before departure.

Good to know

Low seasonApril
Cheapest flight$335
Best time to beat the crowds with an average 9% drop in price.
Most popular time to fly with an average 17% increase in price.
Flight from Santo Domingo to Santiago

When to book flights from Santo Domingo to Santiago

Are your dates flexible? Find out the best times to travel from Santo Domingo to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Santo Domingo to Santiago

  • What is the cheapest flight from Santo Domingo to Santiago?

    In the last 3 days, the lowest price for a flight from Santo Domingo to Santiago was $332 for a one-way ticket and $524 for a round-trip.

  • Do I need a passport to fly between Santo Domingo and Santiago?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Santo Domingo and on arrival in Santiago.

  • Which aircraft models fly most regularly from Santo Domingo to Santiago?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Santo Domingo to Santiago?

    Star Alliance is the only airline alliance operating flights between Santo Domingo and Santiago.

  • Which is the best airline for flights from Santo Domingo to Santiago, Copa Airlines or Avianca?

    The two airlines most popular with KAYAK users for flights from Santo Domingo to Santiago are Copa Airlines and Avianca. With an average price for the route of $744 and an overall rating of 7.6, Copa Airlines is the most popular choice. Avianca is also a great choice for the route, with an average price of $605 and an overall rating of 6.6.

  • How does KAYAK find such low prices on flights from Santo Domingo to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Santo Domingo to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Santo Domingo to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from Santo Domingo is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Santo Domingo to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to Santo Domingo with another airline. Booking your flights between Santo Domingo and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Santo Domingo to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from Santo Domingo up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Santo Domingo to Santiago

 
See real verified KAYAK customer reviews for airlines flying from Santo Domingo to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santo Domingo to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.6
Copa AirlinesOverall score based on 1560 reviews
8.1Crew
6.8Entertainment
7.8Boarding
6.8Food
7.4Comfort
Airline reviews

A lot things happened in this trip.The fly should be less stress.

6.0 GoodIrma, Jan 2026
PTY - MIA
Read more Copa Airlines reviews

A lot things happened in this trip.The fly should be less stress.

There should be a warning regarding the quality of the aircraft on the website as we reserve the tickets. There was no TV or any type of screen onboard. The wifi they offer is good for nothing. Traveling 9 hours straight with kids and no type of entetainment was horrible. I wish I had been informed prior so I could buy a ticket with another airline. The food was a joke too. A very tiny portion per passenger. They also charged $100 per checked bag. With United I used to pay $60. So, fair to say that I wont be flying Copa anymore. Their aircraft was super old, outdated, no entertainment, with nearly no onboard food.

I always enjoy flying Copa. There are very few airlines where I can enjoy a comfortable sleep in-flight. The snacks weren't the best, but they sufficed. The in-flight entertainment was fantastic, and I crossed another movie off my watch list.

Some of the Air hostesses are not that friendly. Need improvement

They were super friendly bumped me up to exit row free of charge, All flight legs were on time

As always, Copa Airlines is great to fly on. The flights are always on time, the staff are pleasant and helpful and it's always a wonderful flying experience.

Cops Airlines is fantastic! The level of care and professionalism provided by the entire crew was top rate.

We had a great flight just wished they had a tv so we can see a movie that would of made my trip excellent.

horrible service, food was an embarrassment, no charging for cellphones, stay away

Great experience with a crew always thinking in the passenger

We found the chairs to be really uncomfortable. It’s also really unacceptable that no form of food or drink is included in a 6+ hour flight

Not good, tried to purchase a first class upgrade and they couldn’t get it done. Was super uncomfortable the whole time.

The flight attendant smashed her beverage cart into my knee, causing significant amount of pain. The seats were extremely uncomfortable. No food or drink is offered unless you want to pay the ridiculous prices for it. The schedule of flying in the overnight hours is also very uncomfortable.

We waited for one hour to deboard the plane after landing. That could be better

I handed in my suitcase in perfect condition at SAL Airport. And in MIA Airport I received it with one corner broken and the wheels bent.

I like the crew members they're very friendly. Clean plane. The flight was on time. I dont like the comfort my car seat its better that the plane seats. They charge for everything. This airline was very good. Now it's a low cost airline

No free snacks nor drinks on very short 30min flight. Entertainment system is over wifi to your own phone or tablet, which is good but often a show or movie just stops and refuses to continue

I like the crew they're very friendly. I don't like. on five hour flight they not offered snacks. Any drink. Not even coffee

Not even water is offered on the flight. You cannot lean back on the seats and the seats are so narrow you can’t avoid rubbing elbows with the person next to you.

I couldnt recline the seat. Other than that crew was very attentive and helpful. Thsnk you

Everything you need to know for your flight from Santo Domingo to Santiago

Information on your arrival and departure airports