$509 Find Cheap Flights from Wilmington to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Wilmington to South America departing on 5/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Wilmington to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Santiago
Santiago3 stops$1,064
Quito
Quito2 stops$810
Santiago
Santiago3 stops$1,064
Quito
Quito2 stops$810

Book Cheap Wilmington to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Wilmington to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Wilmington to South America

Sat, Sep 26 - Sat, Oct 3
American Airlines Logo
6:00 am - 12:36 pm
ILM
-
MDE
7h 36m
1 stop
American Airlines Logo
3:05 pm - 11:18 pm
MDE
-
ILM
7h 13m
1 stop
$561American Airlines
Sat, Sep 26 - Sat, Oct 3
American Airlines Logo
6:17 am - 8:00 pm
ILM
-
MDE
14h 43m
2 stops
American Airlines Logo
3:05 pm - 11:18 pm
MDE
-
ILM
7h 13m
1 stop
$566American Airlines
Sat, Sep 26 - Sat, Oct 3
American Airlines Logo
7:18 am - 8:00 pm
ILM
-
MDE
13h 42m
2 stops
American Airlines Logo
3:05 pm - 10:19 am
MDE
-
ILM
18h 14m
2 stops
$576American Airlines
Tue, May 19 - Fri, May 22
LATAM Airlines Logo
6:00 am - 4:43 am
ILM
-
UIO
23h 43m
2 stops
LATAM Airlines Logo
12:59 am - 11:06 am
UIO
-
ILM
9h 07m
1 stop
$810LATAM Airlines
Sat, May 16 - Mon, May 25
LATAM Airlines Logo
4:46 pm - 4:43 am
ILM
-
UIO
12h 57m
2 stops
LATAM Airlines Logo
12:59 am - 1:36 pm
UIO
-
ILM
11h 37m
1 stop
$850LATAM Airlines
Thu, May 21 - Fri, May 29
Multiple Airlines Logo
9:45 pm - 4:17 am
ILM
-
SCL
30h 32m
3 stops
Multiple Airlines Logo
1:11 am - 8:56 pm
SCL
-
ILM
43h 45m
3 stops
$1,064Multiple Airlines
Thu, May 21 - Sat, May 30
Multiple Airlines Logo
9:45 pm - 4:17 am
ILM
-
SCL
30h 32m
3 stops
Multiple Airlines Logo
6:40 am - 4:43 pm
SCL
-
ILM
34h 03m
3 stops
$1,086Multiple Airlines
Sat, May 23 - Sun, May 31
Delta Logo
6:00 am - 6:25 am
ILM
-
SCL
24h 25m
2 stops
Delta Logo
10:55 pm - 11:24 pm
SCL
-
ILM
24h 29m
2 stops
$1,190Delta
Thu, May 28 - Sun, May 31
United Airlines Logo
4:05 pm - 2:30 am
ILM
-
MAO
34h 25m
2 stops
United Airlines Logo
3:35 am - 3:24 pm
MAO
-
ILM
35h 49m
2 stops
$1,539United Airlines
Tue, May 19 - Sat, May 23
United Airlines Logo
6:00 am - 11:25 pm
ILM
-
UIO
18h 25m
2 stops
United Airlines Logo
7:25 am - 3:22 pm
UIO
-
ILM
30h 57m
2 stops
$2,925United Airlines
Booking Insights

KAYAK's insights & trends for Wilmington to South America flights

Get data-powered insights and trends into flights from Wilmington to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Wilmington to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Wilmington to South America were found on American Airlines ($561) and LATAM Airlines ($728).

Good to know

Cheapest flight$509
Flight from Wilmington to Santiago

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Wilmington to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Wilmington to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Wilmington to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Wilmington to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Wilmington to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Wilmington to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Wilmington to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Wilmington to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Wilmington to South America

 
Need help choosing which airline to fly with from Wilmington to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8386 reviews
7.8Entertainment
7.2Food
8.1Boarding
7.9Comfort
8.5Crew
Airline reviews

We departed and landed early which was a nice surprise. The boarding process was slow.

10.0 ExcellentBrittany, Apr 2026
DAL - ATL
Read more Delta reviews

We departed and landed early which was a nice surprise. The boarding process was slow.

N Everything was perfect from boarding to assistance to baggage in Tampa

Subpar. The seating on the plane is almost unbearable. We are literally touching and/or sitting on each other which is totally unacceptable and shameful. Pilots and crew was very accommodating and friendly.

The boarding was organized and informative but the plane was tight meaning that you were sitting on one another and extremely uncomfortable. It’s disappointing that can’t have common seating comfort on the plane.

Loved the crew! Sucks that we went from 1 hour and 8 minute layover to a 3 hour layover. But weather sucks like that.

I was told that they needed to check my bag at the gate and to pick it up at the gate in Richmond. No big deal. I know they can't control the weather, but we flew around RIC for 45 minutes to avoid the storm and were 25 minutes late leaving as well. Once we landed, we were told to go to baggage claim to pick up our luggage. I went to bathroom, paid for parking, and went to the assigned baggage claim location. United flight people came down with us as well. They got their luggage immediately. Next, South West people came down about 10 minutes later. They got their luggage next. We finally got our luggage around 30 minutes in waiting. Was not a wonderful experience. No reflection on Delta, but the ground crew was lousy at best.

Everything could have benn better. Short fly, no food, no entertainment and no wifi.

Flight delayed. Air broken. Cabin was hot enough to pass out. Delta shuttle’s becoming worse and worse.

my mom urmila patel needed a wheelchair which was not available on the curbside. she needed to walk almost 50 meters inside (at the risk of falling) and then had to wait in line to get a wheelchair (this is not ok). Once obtained she had to seat in it for 30-45 minutes for someone to take her in thru the checkin process (which was fairly smooth and easy). the lady who helped her with her checkin process was very courteous and helpful

On the return flight, flight attendant Britt went out of her way to inform passengers that several of us had tight connections.

Ceiling fell down and had to have maintenance come and duct tape it up. No WiFi on the flight.

I appreciate that I finally got the seat I paid extra for this time. Thank you

American Airlines did everything they could with the high Spring Break crowd. I was frustrated to be changed from 1st class to a middle seat at the back of the plane. This has happened before, not sure booking 1st class and paying the extra actually works.

Plane from partner PSA was filthy. Plastic needs to be thoroughly cleaned. Really disgusting to look at and wonder about cleanliness of parts less visible.

Arrived early picked up my bag in a few minutes- great trip - thank you

I like that the flight attendant was very attentive and helpful. The meal menu could have more of an variety of food choices.

We missed our flight and got stranded in Miami where we had to rent a hotel we could not afford. they would not work with us because they said it was weather related even though the gate attendant said it was not. I could go on but trying to get satisfaction has wore me down, which I believe is the intent. My only solution is to never fly AA again.

Overall it was a good flight. Because we traveled on a Saturday we were upgraded to FC since my wife and I are both Executive Platinum. The only areas for improvement we noted are better snack assortment and perhaps a little nicer plane as American is flying some older planes now. Everything else on this flight was excellent, which is frankly not the norm for American since we have had multiple issues on prior AA flights.

Didn't get a seat assignment until the last minute even though i picked a seat.

Flight was smooth, quick and felt safe. The 2 delays not happening would have been better but I guess that happens in the airline industry

Everything you need to know for your flight to South America

Information on your arrival and departure airports