$540 Find Cheap Flights from Wilmington to South America

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Wilmington to South America departing on 3/29. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Wilmington to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Bogotá
Bogotá1 stop$766
Santiago
Santiago1 stop$784
Quito
Quito2 stops$664
Bogotá
Bogotá1 stop$766
Santiago
Santiago1 stop$784
Quito
Quito2 stops$664

Book Cheap Wilmington to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Wilmington to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Wilmington to South America

Sun, Mar 29 - Sun, Apr 5
Multiple Airlines Logo
2:25 pm - 12:21 am
ILM
-
MDE
10h 56m
2 stops
Multiple Airlines Logo
1:52 pm - 1:08 pm
MDE
-
ILM
22h 16m
1 stop
$540Multiple Airlines
Wed, Apr 15 - Sun, Apr 19
American Airlines Logo
5:00 am - 8:15 pm
ILM
-
MDE
16h 15m
2 stops
American Airlines Logo
1:50 pm - 10:34 am
MDE
-
ILM
19h 44m
2 stops
$580American Airlines
Sun, Mar 29 - Sun, Apr 5
American Airlines Logo
7:57 pm - 1:10 pm
ILM
-
MDE
18h 13m
1 stop
American Airlines Logo
6:00 am - 7:17 pm
MDE
-
ILM
12h 17m
1 stop
$583American Airlines
Sat, May 16 - Fri, Jun 5
Delta Logo
4:46 pm - 4:43 am
ILM
-
UIO
36h 57m
2 stops
Delta Logo
6:50 pm - 3:59 pm
UIO
-
ILM
20h 09m
2 stops
$664Delta
Fri, May 15 - Fri, Jun 5
Delta Logo
6:16 pm - 6:59 pm
ILM
-
UIO
25h 43m
1 stop
Delta Logo
6:50 pm - 3:59 pm
UIO
-
ILM
20h 09m
2 stops
$703Delta
Sat, Apr 25 - Tue, Apr 28
LATAM Airlines Logo
6:00 am - 6:59 pm
ILM
-
UIO
13h 59m
1 stop
LATAM Airlines Logo
12:59 am - 1:38 pm
UIO
-
ILM
11h 39m
1 stop
$722LATAM Airlines
Fri, Apr 24 - Mon, Apr 27
LATAM Airlines Logo
5:50 pm - 4:43 am
ILM
-
UIO
11h 53m
2 stops
LATAM Airlines Logo
12:59 am - 1:38 pm
UIO
-
ILM
11h 39m
1 stop
$726LATAM Airlines
Sat, Apr 25 - Tue, Apr 28
LATAM Airlines Logo
6:00 am - 6:59 pm
ILM
-
UIO
13h 59m
1 stop
LATAM Airlines Logo
12:59 am - 1:38 pm
UIO
-
ILM
11h 39m
1 stop
$732LATAM Airlines
Tue, Jul 14 - Tue, Aug 11
GOL Logo
9:19 am - 11:55 pm
ILM
-
UIO
15h 36m
2 stops
GOL Logo
6:09 am - 7:05 pm
UIO
-
ILM
11h 56m
2 stops
$895GOL
Fri, Jun 12 - Fri, Jun 19
GOL Logo
3:21 pm - 8:50 am
ILM
-
EZE
16h 29m
2 stops
GOL Logo
8:55 pm - 11:21 pm
EZE
-
ILM
27h 26m
2 stops
$1,728GOL
Booking Insights

KAYAK's insights & trends for Wilmington to South America flights

Get data-powered insights and trends into flights from Wilmington to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Wilmington to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Wilmington to South America were found on American Airlines ($580) and Delta ($664).

Good to know

Cheapest flight$540
Flight from Wilmington to Medellín

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Wilmington to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Wilmington to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Wilmington to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Wilmington to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Wilmington to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Wilmington to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Wilmington to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Wilmington to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Wilmington to South America

 
Need help choosing which airline to fly with from Wilmington to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8180 reviews
8.5Crew
7.2Food
7.9Comfort
8.1Boarding
7.8Entertainment
Airline reviews

boarded at 5:30 pm, pushed away from gate at 6pm ... takeoff was not until ~6:45pm; disappointing

4.0 OkayLawrence, Feb 2026
LGA - JAX
Read more Delta reviews

boarded at 5:30 pm, pushed away from gate at 6pm ... takeoff was not until ~6:45pm; disappointing

Smooth boarding, pleasant and professional lady checking us in. Crew service was excellent, again pleasant, but professional. Nice touch-down on landing! Thank you Delta. 💗

Originally, I was booked in economy. I paid several hundred additional dollars to upgrade to first class. Then I paid several more hundred dollars to change my flight to a slightly earlier flight. I asked if the changed flight would also seat me in first class, and I was told that it would. When I boarded the plane, however, I was seated in economy. So, I paid $500-600 more than I paid for my original ticket for an upgrade and a changed flight - received the changed flight (which was nice), but did not receive the upgrade. So, I was not completely satisfied.

Awesome! On time flight, early arrival, and a complimentary upgrade!

Paid for wifi that didn't work. No plug in seat to work. No entertainment.

We departed early and made up time in the air allowing us to arrive 30 minutes early. Capt was incredibly genuine and thanked every passenger for flying with Delta. Completely humble and professional!

Was forced to check in my small carry on, even though I informed the crew it has very fragile items inside

This was one of the worst flights I’ve been on in years. I upgraded to comfort and had such an uncomfortable experience. The person next to me was oversized - which I understand - however, they took up their space and mine. I could only use about 50% of my seat space to not be physically touching this person the entire flight and there was no spatial awareness. I also could not use the seat outlet because their body was obstructing it. It was very inconvenient. Their body kept touching me repeatedly during the flight and I felt very uncomfortable. To pay more for an upgraded space and then not even being able to use it was highly disappointing.

No wheel chair as requested at Atlanta arrival on first flight.

Only freetext wifi was available in flight; browsing WiFi required payment. Since the seats had no in flight entertainment, Delta should revisit this policy on this longer flight.

Flight was smooth, quick and felt safe. The 2 delays not happening would have been better but I guess that happens in the airline industry

2 hour delay due to equipment failure. No updates via the app and airport screens (which continued to show a departure time in the past). AA eventually switched planes and the new plane was not catered or cleaned correctly.

Could we please end the loud announcements about credit card offers on your flights? We are trying to sleep, work, watch videos, etc. and if we need a credit card, we will ask for one. Flying is already not what it used to be.

Bags took over and hour to come out. Delays due to wind caused rebooking.

Lower WiFi prices; allow us to see our flight on a map; more variety of drink choices.

Flight was on time is the only good thing. Person loading the plane called 1-6 to board at the same time, made it chaotic. Plane was too small for even putting backpacks in overhead. Seat for normal sized people were too small. The WIFI didn't work. When we landed had to wait because not enough ground crew.

Did not understand a single word the attendant said on the pa system. I was glad it was not an emergency.

Awful. They won’t help me with anything. I booked on American but they abdicated to Iberia. The ticket was overpriced. Everything negative

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

After arriving in Dallas, the aircraft taxied for an unusually long time and was unable to park at the gate, which caused a significant delay and made me miss my connecting flight. I then had to wait in a very long line to be rebooked, and I was told that no hotel or meal accommodations would be provided. What is even more unacceptable is that my luggage was mishandled and has still not been located. My suitcase contains important medications that I urgently need, and I have been unable to access them due to the airline’s mishandling. This situation has caused me considerable stress and inconvenience, and I need this issue to be resolved immediately.

Everything you need to know for your flight to South America

Information on your arrival and departure airports