$377 Find Cheap Flights from Wilmington to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Wilmington to South America departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

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Cheap Flights from Wilmington to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Santiago
Santiago1 stop$767
Quito
Quito1 stop$749
Santiago
Santiago1 stop$767
Quito
Quito1 stop$749

Book Cheap Wilmington to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Wilmington to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Wilmington to South America

Sat, Nov 22 - Sun, Nov 30
American Airlines Logo
6:00 am - 11:02 pmILM-UIO
17h 02m1 stop
American Airlines Logo
8:27 am - 11:44 pmUIO-ILM
15h 17m1 stop
$749American Airlines
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Sat, Nov 22 - Sat, Nov 29
American Airlines Logo
6:00 am - 11:02 pmILM-UIO
17h 02m1 stop
American Airlines Logo
12:55 am - 11:44 pmUIO-ILM
22h 49m1 stop
$760American Airlines
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Wed, Jan 7 - Wed, Jan 21
American Airlines Logo
6:00 am - 7:55 amILM-SCL
23h 55m1 stop
American Airlines Logo
10:15 pm - 3:40 pmSCL-ILM
19h 25m2 stops
$767American Airlines
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Wed, Jan 7 - Wed, Jan 21
American Airlines Logo
6:00 am - 7:55 amILM-SCL
23h 55m1 stop
American Airlines Logo
10:15 pm - 11:03 pmSCL-ILM
26h 48m1 stop
$770American Airlines
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Wed, Jan 7 - Wed, Jan 21
American Airlines Logo
2:12 pm - 9:05 amILM-SCL
16h 53m2 stops
American Airlines Logo
10:15 pm - 5:15 pmSCL-ILM
21h 00m2 stops
$774American Airlines
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Sat, Oct 11 - Tue, Oct 14
LATAM Airlines Logo
11:30 am - 6:45 amILM-SCL
18h 15m2 stops
LATAM Airlines Logo
12:25 am - 9:31 amSCL-ILM
34h 06m2 stops
$814LATAM Airlines
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Wed, Jan 7 - Tue, Jan 20
LATAM Airlines Logo
6:00 am - 6:10 amILM-SCL
22h 10m1 stop
LATAM Airlines Logo
4:35 am - 11:54 pmSCL-ILM
21h 19m2 stops
$819LATAM Airlines
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Sat, Nov 22 - Sun, Nov 30
Delta Logo
4:30 pm - 7:05 pmILM-UIO
26h 35m2 stops
Delta Logo
9:11 am - 9:36 amUIO-ILM
24h 25m2 stops
$881Delta
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Sat, Nov 22 - Sun, Nov 30
Delta Logo
4:30 pm - 7:05 pmILM-UIO
26h 35m2 stops
Delta Logo
9:11 am - 9:36 amUIO-ILM
24h 25m2 stops
$901Delta
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Thu, Oct 2 - Mon, Oct 6
United Airlines Logo
7:05 am - 8:00 amILM-EZE
23h 55m2 stops
United Airlines Logo
9:00 pm - 11:24 pmEZE-ILM
27h 24m2 stops
$1,380United Airlines
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Booking Insights

KAYAK's insights & trends for Wilmington to South America flights

Get data-powered insights and trends into flights from Wilmington to South America to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Wilmington to South America?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Wilmington to South America were found on American Airlines ($749) and LATAM Airlines ($814).

Good to know

Cheapest flight$377
Flight from Wilmington to Quito

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Wilmington to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Wilmington to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Wilmington to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Wilmington to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Wilmington to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Wilmington to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Wilmington to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Wilmington to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the morning, when round-trip flights cost $748 on average. Morning departures are around 6% cheaper than evening flights, on average. The most expensive time of day to fly to South America is generally in the evening, which is peak travel time and where the average cost of a ticket is $799.

Reviews of the top airlines flying from Wilmington to South America

 
Need help choosing which airline to fly with from Wilmington to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 7982 reviews
8.5Crew
8.2Boarding
7.3Food
7.9Entertainment
7.9Comfort
Airline reviews

On this flight I felt the food offering was not as complete as on previous flights. The tomato salad was a bit off and there was nothing additional such a bread or butter. The breakfast was only one option, so you either ate what they had or ate nothing. The crew was efficient, but most seemed frustrated throughout the flight. The flight arrived early and was obstacle-free, so I’m overall quite happy, but the shine in the rest of the experience just wasn’t there.

8.0 ExcellentJeanne, Aug 2025MSY - JFK
Read more Delta reviews

On this flight I felt the food offering was not as complete as on previous flights. The tomato salad was a bit off and there was nothing additional such a bread or butter. The breakfast was only one option, so you either ate what they had or ate nothing. The crew was efficient, but most seemed frustrated throughout the flight. The flight arrived early and was obstacle-free, so I’m overall quite happy, but the shine in the rest of the experience just wasn’t there.

The seats got pretty uncomfortable pretty fast. The armrests are bigger than on other planes, so I had less room in the actual seat. My butt hurt by the end of the flight. :/ comfort was the primary issue. The crew were fantastic!

I believe that a four-hour trip should have a meal. Delta had none.

Great flight with Delta! Boarding was quick and easy, the amenities were solid, and the plane was in great shape. The flight attendants had a fun, lively energy while staying professional. All in all, a smooth trip — even managed to catch up on some rest. Thanks, Delta!

I was uncomfortably cold on the plane. Other than that it was uneventful and therefore as enjoyable as a plane ride can be.

There was supposed to be a meal served, but there wasn’t and the major toilet was out of order

They made us board and then deboard due to mechanical issue which delayed the departure by almost 2 hours and we barely made our connecting flight. These quality checks should've been done before boarding not after.

Having to up charge for a seat assignment is not good. Delta can do better

I liked the friendliness of the staff. The cleanliness of all 3 planes.

Was charged for my luggage despite having been on one ticket from an international flight. Too tired to argue after 15 hours on flight. Was charged for rechecking it at JFK airport. Not sure why those off Kenya Airways were required to do that.

Sat on the ground in Cincinnati for 50 minutes before deplaning

Flight was delayed. Staff at the gate effectively and proactively communicated about the delay.

Overall fine, but the delay was annoying and the reasons for the delay were not communicated. The crew on board were phenomenal!

This flight never occurred because AA couldn’t get their act together.

Boarding was very efficient. Everyone got on board and we got on our way very quickly. It was frustrating that the entertainment app was not functioning properly. I was not able to activate some of the movies offered. The crew on this flight appears to be pretty grumpy. They had no smile on their faces. I felt like they were doing us a favor for being there.

Delayed because of weather in Nashville. I think God or some higher power generally has cursed me when it comes to flying out of Charlotte on American. I'm delayed pretty much everytime. We need Team Cobra Kai types to come in and "sweep the leg(s)" of the Charlotte ops people on principle. Don't let the sweet southern rocking chairs fool you, Charlotte is a sinkhole

Long 5 hour and 45 min flight and only one drink service and cookie snack

Newark airport grounded inbound flight and only announced when the flight was about to start taxing.

Was a normal flight but it was delayed, and there wasn't an explanation.

Terrible. The flight was delayed two hours due to weather. Then when we got on the plane, the first pilot ended up timing out and we had to wait for a second pilot. Second pile came on board and we tax it out. Had to return back to the gate because of an unruly passenger. Then the copilot timed out. Had to wait for new copilot. Also had to wait for maintenance to check for fuel. Then found out the second pilot timed out and we had to wait for a third pilot. Was ready to go and then needed maintenance again for another issue. In the end, it was 2 o’clock in the morning when they announced that the flight couldn’t go because the third pilot and the second copilot had timed out.

Everything you need to know for your flight to South America

Information on your arrival and departure airports

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