CHS - TYS

$108 Find Cheap Flights from Charleston to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Charleston to Knoxville departing on 3/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Charleston to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Charleston to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$235
Multiple Airlines
Tue 3/24Fri 3/27
CHS - TYS • 1 stop
Cheapest one-way
$108
Typical prices: $247-$319
Multiple Airlines
Sat 3/28
CHS - TYS • 1 stop
Top airlines
Southwest
Cheapest • from $263 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Charleston and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Charlotte (CLT)
Cheapest • Avg $396 (round-trip)
Charlotte (CLT)
Shortest trip • 3h 17m (one-way)
Insights
Insights
Insights
Insights
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Charleston to Knoxville (CHS-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Charleston to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Charleston to Knoxville

Tue, Mar 24 - Fri, Mar 27
Multiple Airlines Logo
3:01 pm - 12:51 pm
CHS
-
TYS
21h 50m
1 stop
Multiple Airlines Logo
7:40 am - 10:13 pm
TYS
-
CHS
14h 33m
1 stop
$235Multiple Airlines
Wed, Apr 1 - Wed, Apr 8
Southwest Logo
2:10 pm - 9:10 pm
CHS
-
TYS
7h 00m
1 stop
Southwest Logo
7:05 am - 12:25 pm
TYS
-
CHS
5h 20m
1 stop
$263Southwest
Wed, Apr 1 - Wed, Apr 8
Southwest Logo
2:10 pm - 9:10 pm
CHS
-
TYS
7h 00m
1 stop
Southwest Logo
8:15 am - 8:00 pm
TYS
-
CHS
11h 45m
2 stops
$268Southwest
Wed, Apr 1 - Wed, Apr 8
Southwest Logo
7:55 am - 5:40 pm
CHS
-
TYS
9h 45m
2 stops
Southwest Logo
8:15 am - 5:40 pm
TYS
-
CHS
9h 25m
2 stops
$273Southwest
Wed, Mar 25 - Sat, Mar 28
Southwest Logo
6:15 am - 11:50 am
CHS
-
TYS
5h 35m
1 stop
Southwest Logo
6:35 am - 12:00 pm
TYS
-
CHS
5h 25m
1 stop
$279Southwest
Wed, Apr 8 - Sat, Apr 11
Southwest Logo
12:00 pm - 8:50 pm
CHS
-
TYS
8h 50m
2 stops
Southwest Logo
7:45 am - 2:05 pm
TYS
-
CHS
6h 20m
1 stop
$284Southwest
Mon, Jun 1 - Fri, Jun 5
Multiple Airlines Logo
3:21 pm - 11:37 pm
CHS
-
TYS
8h 16m
1 stop
Multiple Airlines Logo
7:27 pm - 8:48 am
TYS
-
CHS
13h 21m
1 stop
$286Multiple Airlines
Wed, Apr 8 - Sat, Apr 11
Southwest Logo
12:00 pm - 8:50 pm
CHS
-
TYS
8h 50m
2 stops
Southwest Logo
6:40 am - 2:05 pm
TYS
-
CHS
7h 25m
2 stops
$289Southwest
Wed, Mar 25 - Sat, Mar 28
Southwest Logo
7:55 am - 8:05 pm
CHS
-
TYS
12h 10m
2 stops
Southwest Logo
6:35 am - 12:00 pm
TYS
-
CHS
5h 25m
1 stop
$290Southwest
Sat, May 16 - Wed, May 20
Southwest Logo
7:00 am - 6:30 pm
CHS
-
TYS
11h 30m
2 stops
Southwest Logo
8:15 am - 8:00 pm
TYS
-
CHS
11h 45m
2 stops
$295Southwest
Booking Insights

KAYAK's insights & trends for Charleston to Knoxville flights

Get data-powered insights and trends into flights from Charleston to Knoxville to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Charleston to Knoxville?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Charleston to Knoxville were found on Southwest ($263) and American Airlines ($310).

Good to know

Cheapest flight$108
Most popular time to fly and prices are also 24% lower on average.
Flight from Charleston to Knoxville

When to book flights from Charleston to Knoxville

Are your dates flexible? Find out the best times to travel from Charleston to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Charleston to Knoxville

  • What is the cheapest flight from Charleston to Knoxville?

    In the last 3 days, the lowest price for a flight from Charleston to Knoxville was $108 for a one-way ticket and $235 for a round-trip.

  • Do I need a passport to fly between Charleston and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Charleston to Knoxville?

    On your way to Knoxville, you’ll fly out from Charleston. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Charleston to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Charleston to Knoxville?

    SkyTeam, and oneworld are the airline alliances operating flights between Charleston and Knoxville, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Charleston to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Charleston to Knoxville are Delta and American Airlines. With an average price for the route of $485 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $356 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Charleston to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Charleston to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Charleston to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Charleston is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Charleston to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Charleston with another airline. Booking your flights between Charleston and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Charleston to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Charleston up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Charleston to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Charleston to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Charleston to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8245 reviews
7.8Entertainment
8.5Crew
7.9Comfort
7.2Food
8.1Boarding
Airline reviews

I was happy that I was able to get a last minute flight but unfortunately my seat was a middle seat. Even with Delta Comfort I wasn't comfortable

8.0 ExcellentSheila, Mar 2026
ATL - EWR
Read more Delta reviews

I was happy that I was able to get a last minute flight but unfortunately my seat was a middle seat. Even with Delta Comfort I wasn't comfortable

There’s not much to say about a one hour flight. This is a connection from LA to RNO that I missed the previous night due to a mechanical check delay on my originating flight from JFK to LAX. The short flight itself was fine. Instructions from the pilot and crew were per usual. The coffee was barely lukewarm, which possibly was purposeful so we would down it quickly. Bags were already on carousel upon reaching baggage claim, which was excellent.

Flight was warm for first few hours and quite rough

Seat was extremely hard which made even a short 1 hour 20 minute flight fairly uncomfortable.

Everything was good except wifi and a leaking drink chiller. The floor was all wet and my bag was soaked. Did not notice until debarking. Have not heard back from Delta. Even though this was leg one of an international flight in first class, they denied access to their Sky Club - very disappointing!

The staff was fine. The plane was extremely tight, and I paid for the wifi and it did not work at all. I was actually going to ask for a refund.

two hour delay and the Delta representative on the PA system was unable to understand

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

2+hrs delay without any reason provided and a cramped flight

We waited an hour on the runway to get a gate in Orlando

Good crew and flight was on time. It’s a small plane with limited overhead luggage space. They said the overhead space was full and I had to check my bag. There was still space when I got on. Waiting for my checked luggage added 30 minutes to my trip. Not the end of the world but also not great.

My seat was assigned last row behind restrooms No legroom’s I’m very Pettit Still was not comfortable Food choice was excellent

Delayed initially because they couldn’t print the flight details. Poor instruction on delay. When I got on the plane the flight attendant argued with me about whether my carry on would fit (it did, although she didn’t acknowledge that). No greeting (other than arguing with me) getting on or off the plane.

Overall good. The pilots and flight attendants are excellent! The equipment was the issue on my First flight as they had to wait for a part to be installed. So the take off was at least 30 minutes later.

It was an older plane. First Class was not especially roomy or comfortable. It was a short flight so there were no meal but they did offer mixed nuts which used to be normal but now is rare. Crew member was very polite and professional.

The chicken wrap was tiny ($13 for what looked like a 1/3 of a normal wrap?) and disgusting.

It was a train wreck but on an airplane. First off, flight was delayed then we board only to hear two announcements, First weather delays in Orlando and second backup battery warning on emergency lights. After sitting on the plane for almost 2 hours they have us deplane due to the maintenance issue. We were told they were getting another plane. In the mean time, I notice another American- Orlando flight and ask the gate agent if I can switch. He says he cant help me and I'd have to walk to A13 from A37. Really!? I get down there and get a seat only to get an announcement my original flight was RE-boarding. The Then inflight there's no communication and I notice on flightaware were circling over the Gulf of America. I call the flight attendant and of course she has no clue and apparently 5m later the pilot finally tells us about another delay. Why does American always have these service and delay issues? They are my LAST choice in flights now!

Mediocre would be best description. Food bland. Seat biz class uncomfortable to sleep. Crew never dimmed lights completely in an overnight flight to Europe. Would avoid AA if possible.

For my arriving destination, we were delayed multiple times to the point that we arrived 6 hours after we were originally scheduled. On my flight home, they overbooked and involuntarily removed passengers (including me) from the plane. It was not a good experience.

It was good experience this time. The flight was on time.

Everything you need to know for your flight from Charleston to Knoxville

Information on your arrival and departure airports