$165 Find Cheap Flights from Charleston to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Charleston to South America departing on 12/12. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South America

Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Free to useThere are no hidden charges or fees.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Charleston to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$521
Bogotá
Bogotá1 stop$523
Sao Paulo
Sao Paulo2 stops$750
Santiago
Santiago2 stops$704
Cartagena
Cartagena1 stop$276
Quito
Quito1 stop$604
Guayaquil
Guayaquil2 stops$297
Cusco
Cusco2 stops$1,032
Montevideo
Montevideo2 stops$1,386
Lima
Lima1 stop$521
Bogotá
Bogotá1 stop$523
Sao Paulo
Sao Paulo2 stops$750
Santiago
Santiago2 stops$704
Cartagena
Cartagena1 stop$276
Quito
Quito1 stop$604
Guayaquil
Guayaquil2 stops$297
Cusco
Cusco2 stops$1,032
Montevideo
Montevideo2 stops$1,386

Book Cheap Charleston to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Charleston to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Charleston to South America

Mon, Dec 1 - Thu, Dec 4
Spirit Airlines Logo
6:50 am - 12:56 amCHS-MDE
18h 06m1 stop
Spirit Airlines Logo
2:05 am - 8:54 pmMDE-CHS
18h 49m1 stop
$266Spirit Airlines
Find Deal
Tue, Dec 2 - Fri, Dec 5
Spirit Airlines Logo
6:50 am - 1:25 pmCHS-CTG
6h 35m1 stop
Spirit Airlines Logo
2:15 pm - 8:54 pmCTG-CHS
6h 39m1 stop
$276Spirit Airlines
Find Deal
Sun, Feb 8 - Sat, Feb 14
American Airlines Logo
6:10 am - 11:22 pmCHS-GYE
17h 12m2 stops
American Airlines Logo
3:31 pm - 10:45 amGYE-CHS
19h 14m2 stops
$297American Airlines
Find Deal
Mon, Dec 1 - Mon, Dec 8
Multiple Airlines Logo
6:50 am - 9:40 pmCHS-MDE
14h 50m1 stop
Multiple Airlines Logo
1:00 pm - 8:54 pmMDE-CHS
7h 54m1 stop
$299Multiple Airlines
Find Deal
Mon, Dec 1 - Fri, Dec 5
Multiple Airlines Logo
6:50 am - 12:56 amCHS-MDE
18h 06m1 stop
Multiple Airlines Logo
2:05 am - 10:59 pmMDE-CHS
20h 54m2 stops
$322Multiple Airlines
Find Deal
Sun, Feb 8 - Sat, Feb 14
American Airlines Logo
6:10 am - 11:22 pmCHS-GYE
17h 12m2 stops
American Airlines Logo
3:31 pm - 11:59 pmGYE-CHS
8h 28m1 stop
$463American Airlines
Find Deal
Tue, Dec 2 - Tue, Dec 9
Delta Logo
5:25 am - 2:17 pmCHS-CTG
8h 52m1 stop
Delta Logo
3:32 pm - 11:50 pmCTG-CHS
8h 18m1 stop
$513Delta
Find Deal
Wed, Dec 3 - Tue, Dec 9
Delta Logo
8:00 am - 12:31 amCHS-CTG
16h 31m2 stops
Delta Logo
3:32 pm - 11:50 pmCTG-CHS
8h 18m1 stop
$519Delta
Find Deal
Mon, Jan 12 - Tue, Jan 20
LATAM Airlines Logo
6:30 am - 9:20 pmCHS-LIM
14h 50m1 stop
LATAM Airlines Logo
12:15 pm - 11:58 pmLIM-CHS
11h 43m1 stop
$624LATAM Airlines
Find Deal
Mon, Jan 12 - Tue, Jan 20
LATAM Airlines Logo
6:30 am - 9:20 pmCHS-LIM
14h 50m1 stop
LATAM Airlines Logo
12:05 pm - 12:07 pmLIM-CHS
24h 02m2 stops
$653LATAM Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Charleston to South America flights

Get data-powered insights and trends into flights from Charleston to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Charleston to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Charleston to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Charleston to South America is April, when tickets cost $625 (return) on average. On the other hand, the most expensive months are December and February, when the average cost of round-trip tickets is $1,572 and $850 respectively.

What’s the cheapest day of the week to fly from Charleston to South America?

The average price of all round-trip flights from Charleston to South America clicked on KAYAK for each day over the last 12 months.

For Charleston to South America, Monday is the cheapest day to fly on average and Friday is the most expensive. Flying from South America back to Charleston, the best deals are generally found on Wednesday, with Thursday being the most expensive.

Good to know

Low seasonApril
Cheapest flight$165
Best time to beat the crowds with an average 12% drop in price.
Most popular time to fly with an average 35% increase in price.
Flight from Charleston to Cartagena

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Charleston to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Charleston to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Charleston to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Charleston to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Charleston to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Charleston to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Charleston to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Charleston to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the evening, when round-trip flights cost $659 on average. Morning departures are around 10% more expensive than evening flights, on average. The most expensive time of day to fly to South America is generally at night, which is peak travel time and where the average cost of a ticket is $833.

Reviews of the top 3 airlines serving from Charleston to South America

 
Need help choosing which airline to fly with from Charleston to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7997 reviews
8.5Crew
7.9Comfort
8.2Boarding
7.3Food
7.9Entertainment
Airline reviews

Everything went well and was good. Nothing exceptional, but no complaints either. Cheap seats are pretty comfortable.

8.0 ExcellentPAULINA, Oct 2025LAS - ATL
Read more Delta reviews

Everything went well and was good. Nothing exceptional, but no complaints either. Cheap seats are pretty comfortable.

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

They ended up paying for the bag twice, but the counter wouldn't take my baggage receipt. Left it to me to resolve. Not sure how to resolve the issue.

The customer service before board was very rude and when I expressed my concerns about making the connecting flight she laughed and told me I bought the wrong ticket. I explained once it showed the flight was delayed it no longer let me change seats or anything. I was trying to upgrade to make sure I would get to the next gate on time.

Non stop on long haul is the way to go. Great experience

The aircraft interior is old and tired on this aircraft. The entertainment system never worked despite the crews attempt to reset the system.

The flight used a B767 with a very old interior from before 2014. The entertainment system did not work at all during the flight despite attempts to reset the system. It was like they flew this route just to be competitive.

Old plane and old configuration/seats but still comfortable for a morning flight

They changed planes and the new plane couldn’t carry enough fuel to fly across the country so we had to stop in Kansas City to refuel. Flight was delayed .

Flight was too crowded and seats are too small, especially since passengrs are getting larger. Having a middle seat is ALWAYS tough! Woman on my left was large & kept creeping in to my space. Flight personnel were great! Have more savory rather than sweet snacks please.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

My entertainment did not work. I was very tired from the botched connection, and the poor sleep

Boarding was done by woman who insisted on strict standing in line policy; food was ok; entertainment minimal

entertainment was not good; the shoulder strap on Business class seat did not sit well across the body (more like across the neck); the food was not hot and the special meal promoted by insert in the menu was not available to us

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

The flight attendant, a black woman with curly hair who sat near Row 21, was wonderful and kind.

It was good..clean, comfy seat. Friendly warm welcoming crew. Was able to check my cabin luggage at the gate which I was able to pickup in a decent time from baggage claim. The app gave all updates from delays to baggage claim info. Overall smooth flight.

Flight was delayed leaving Dallas. Arrived about 2 hours later than scheduled.

Flight delayed and missed connection. Rescheduled flight cancelled after 6 hrs wait. Rerouted thru ORD, flight cancelled, overnight stay in ORD. Still in the air on new flight!

We are too tired and frustrated to comment politely at this point

Terrible. Our luggage was delayed and couldn’t be delivered for several days. We got bad information from the airline agents at baggage claim. We had to pick up our car so we wouldn’t be charged for an extra day. We got lost in the maze of airport parking. The baggage claim agents didn’t offer us any compensation for our extra time and expense. We are tired, hungry and very frustrated.

The flight was flawless and we even arrived between 20 and 25 minutes early!

The only thing to like was that we eventually got to our destination

Everything you need to know for your flight to South America

Information on your arrival and departure airports

Not what you’re looking for? Find thousands of other hotels, flights, car rentals and package deals with KAYAK.