$124 Find Cheap Flights from Charleston to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Charleston to South America departing on 4/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Charleston to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$508
Bogotá
Bogotá1 stop$306
Sao Paulo
Sao Paulo1 stop$884
Santiago
Santiago2 stops$704
Cartagena
Cartagena1 stop$252
Quito
Quito1 stop$653
Guayaquil
Guayaquil2 stops$293
Cusco
Cusco2 stops$943
Lima
Lima1 stop$508
Bogotá
Bogotá1 stop$306
Sao Paulo
Sao Paulo1 stop$884
Santiago
Santiago2 stops$704
Cartagena
Cartagena1 stop$252
Quito
Quito1 stop$653
Guayaquil
Guayaquil2 stops$293
Cusco
Cusco2 stops$943

Book Cheap Charleston to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Charleston to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Charleston to South America

Tue, Mar 3 - Sun, Mar 8
American Airlines Logo
7:45 pm - 2:31 pm
CHS
-
GYE
18h 46m2 stops
American Airlines Logo
2:30 pm - 10:50 am
GYE
-
CHS
19h 20m2 stops
$293American Airlines
Tue, Mar 3 - Sun, Mar 8
American Airlines Logo
10:57 am - 2:31 pm
CHS
-
GYE
27h 34m1 stop
American Airlines Logo
2:30 pm - 10:50 am
GYE
-
CHS
19h 20m2 stops
$299American Airlines
Thu, May 28 - Thu, Jun 11
Spirit Airlines Logo
7:00 am - 11:01 pm
CHS
-
GYE
17h 01m1 stop
Spirit Airlines Logo
11:59 pm - 10:41 pm
GYE
-
CHS
21h 42m1 stop
$303Spirit Airlines
Thu, Jan 22 - Thu, Feb 19
Spirit Airlines Logo
6:35 pm - 2:07 pm
CHS
-
BOG
19h 32m1 stop
Spirit Airlines Logo
3:05 pm - 5:30 pm
BOG
-
CHS
26h 25m1 stop
$306Spirit Airlines
Thu, Jan 22 - Mon, Jan 26
Multiple Airlines Logo
6:35 pm - 2:07 pm
CHS
-
BOG
19h 32m1 stop
Multiple Airlines Logo
1:45 pm - 8:38 am
BOG
-
CHS
18h 53m1 stop
$333Multiple Airlines
Sat, Jan 24 - Sat, Jan 31
Multiple Airlines Logo
6:35 pm - 12:50 pm
CHS
-
BOG
18h 15m2 stops
Multiple Airlines Logo
1:45 pm - 8:38 am
BOG
-
CHS
18h 53m1 stop
$340Multiple Airlines
Sat, Apr 4 - Mon, Apr 13
Delta Logo
5:20 am - 8:20 pm
CHS
-
LIM
16h 00m2 stops
Delta Logo
8:55 am - 11:51 pm
LIM
-
CHS
13h 56m2 stops
$608Delta
Sat, Apr 4 - Sun, Apr 19
Delta Logo
5:20 am - 8:20 pm
CHS
-
LIM
16h 00m2 stops
Delta Logo
11:20 pm - 9:47 am
LIM
-
CHS
9h 27m1 stop
$628Delta
Mon, Feb 2 - Thu, Feb 5
LATAM Airlines Logo
5:18 pm - 5:00 am
CHS
-
LIM
11h 42m1 stop
LATAM Airlines Logo
12:15 pm - 11:55 pm
LIM
-
CHS
11h 40m1 stop
$650LATAM Airlines
Mon, Feb 2 - Thu, Feb 5
LATAM Airlines Logo
12:53 pm - 8:00 am
CHS
-
LIM
19h 07m2 stops
LATAM Airlines Logo
11:50 am - 11:48 am
LIM
-
CHS
23h 58m2 stops
$653LATAM Airlines
Booking Insights

KAYAK's insights & trends for Charleston to South America flights

Get data-powered insights and trends into flights from Charleston to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Charleston to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Charleston to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Charleston to South America is April, when tickets cost $355 (return) on average. On the other hand, the most expensive months are December and November, when the average cost of round-trip tickets is $1,047 and $891 respectively.

What’s the cheapest day of the week to fly from Charleston to South America?

The average price of all round-trip flights from Charleston to South America clicked on KAYAK for each day over the last 12 months.

For Charleston to South America, Monday is the cheapest day to fly on average and Friday is the most expensive. Flying from South America back to Charleston, the best deals are generally found on Wednesday, with Thursday being the most expensive.

Good to know

Low seasonOctober
Cheapest flight$124
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 8% lower on average.
Flight from Charleston to Guayaquil

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Charleston to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Charleston to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Charleston to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Charleston to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Charleston to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Charleston to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Charleston to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Charleston to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the evening, when round-trip flights cost $659 on average. Morning departures are around 10% more expensive than evening flights, on average. The most expensive time of day to fly to South America is generally at night, which is peak travel time and where the average cost of a ticket is $833.

Reviews of the top 3 airlines serving from Charleston to South America

 
Need help choosing which airline to fly with from Charleston to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8007 reviews
8.1Boarding
7.9Comfort
7.9Entertainment
8.5Crew
7.3Food
Airline reviews

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

6.0 GoodJeff, Dec 2025
JFK - MIA
Read more Delta reviews

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

Lady Pilot was perfect in every way wheels up to wheels down communication, professionalism, excellent on time departure and on time arrival, excellent communication! Fantastic job with Superb attitude!!

The food is terrible. The staff is wonderful. Comfort is good.

Left on time, a bit delayed due to headwinds most of the trip.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Getting to the flight was arduous and lengthy. The flight itself was good but the food option wasn’t a good selection. I need to do a Kosher option on my return. Flight crew were nice

Good seats in Main cabin, excellent service and excellent landing

My flight was cancelled with no explanation after I had already cleared security. I was given 4 options to rebook, only one being non-stop like I had paid for. I grabbed it. It was 4 plus hours later and then took off even later. Biggest complaint is that I booked early and had an aisle seat. They gave me a "window" seat in front of the exit row, so the seat did not decline. I weigh all of 103 #s and it was tight for me! For what I paid, I feel I was kind of ripped off. I think they should have given me the empty comfort seat for the inconvenience. There was no apology nor any explanation as to why the flight was cancelled. My guess is it benefitted Delta in some way.

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

Staff was exceptional! Everyone was kind, professional and friendly making the trip very pleasant. Thank you!

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

The way the Pilot made all announcements, specially the way he congratulated the entire crew as the best team ever, making a comment that due to them they were able to shorter the delay to the destination. Amazing flight .

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

Really bad experience – delayed for 6 hours without any notice, no food or drinks provided, and stuck in the horrible Cartagena airport.

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

Awful. They won’t help me with anything. I booked on American but they abdicated to Iberia. The ticket was overpriced. Everything negative

it was fine, decent flight... dont get food besides cookies or pretzels so not sure why you ask about food. same for entertainment..

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

I got sick nothing contagious but distressing enough and the care I received on the flight was astounding.

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

A little late at the start but all worked out well.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

I liked the humor of the captain and crew on the flight from Flagstaff to Dallas. They were humorous.

AA delayed the flight for 3 hours and 50 minutes, but delayed the last 2 hours, 30 minutes at a time, so if we knew before, could have stayed at home and worked instead of being at the airport wasting time... The plane's crew was excellent, not their fault.

Everything you need to know for your flight to South America

Information on your arrival and departure airports