$125 Find Cheap Flights from Charleston to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Charleston to South America departing on 4/11. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Charleston to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$666
Bogotá
Bogotá2 stops$483
Sao Paulo
Sao Paulo1 stop$820
Santiago
Santiago1 stop$864
Cartagena
Cartagena1 stop$446
Quito
Quito1 stop$515
Guayaquil
Guayaquil2 stops$344
Cusco
Cusco2 stops$932
Lima
Lima1 stop$666
Bogotá
Bogotá2 stops$483
Sao Paulo
Sao Paulo1 stop$820
Santiago
Santiago1 stop$864
Cartagena
Cartagena1 stop$446
Quito
Quito1 stop$515
Guayaquil
Guayaquil2 stops$344
Cusco
Cusco2 stops$932

Book Cheap Charleston to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Charleston to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Charleston to South America

Mon, May 11 - Mon, May 25
American Airlines Logo
8:21 pm - 1:31 pm
CHS
-
GYE
18h 10m
2 stops
American Airlines Logo
2:31 pm - 12:08 pm
GYE
-
CHS
20h 37m
2 stops
$344American Airlines
Tue, Mar 31 - Sun, Apr 5
Spirit Airlines Logo
8:07 am - 12:21 am
CHS
-
MDE
17h 14m
1 stop
Spirit Airlines Logo
1:17 am - 10:13 pm
MDE
-
CHS
19h 56m
1 stop
$346Spirit Airlines
Tue, May 12 - Mon, May 25
Multiple Airlines Logo
10:38 am - 1:00 pm
CHS
-
MDE
27h 22m
1 stop
Multiple Airlines Logo
1:55 pm - 8:38 am
MDE
-
CHS
17h 43m
1 stop
$391Multiple Airlines
Sun, May 3 - Fri, May 15
Multiple Airlines Logo
10:48 pm - 1:00 pm
CHS
-
MDE
15h 12m
1 stop
Multiple Airlines Logo
1:55 pm - 8:48 am
MDE
-
CHS
17h 53m
1 stop
$397Multiple Airlines
Thu, Apr 30 - Mon, May 4
JetBlue Logo
8:29 pm - 1:00 pm
CHS
-
CTG
17h 31m
1 stop
JetBlue Logo
2:05 pm - 7:13 pm
CTG
-
CHS
28h 08m
1 stop
$446JetBlue
Mon, May 11 - Mon, May 25
JetBlue Logo
8:08 pm - 2:26 pm
CHS
-
GYE
19h 18m
1 stop
JetBlue Logo
12:59 pm - 9:49 am
GYE
-
CHS
19h 50m
1 stop
$460JetBlue
Tue, Apr 28 - Tue, May 5
Delta Logo
7:25 am - 6:30 pm
CHS
-
CTG
12h 05m
2 stops
Delta Logo
4:25 am - 8:41 pm
CTG
-
CHS
15h 16m
2 stops
$555Delta
Mon, Jun 8 - Mon, Jun 29
LATAM Airlines Logo
7:59 pm - 8:10 pm
CHS
-
BOG
25h 11m
2 stops
LATAM Airlines Logo
8:40 am - 11:57 pm
BOG
-
CHS
14h 17m
2 stops
$572LATAM Airlines
Mon, May 11 - Mon, May 25
Delta Logo
9:25 am - 4:43 am
CHS
-
UIO
20h 18m
2 stops
Delta Logo
6:50 pm - 2:03 pm
UIO
-
CHS
18h 13m
2 stops
$611Delta
Tue, Jul 7 - Fri, Jul 17
LATAM Airlines Logo
7:30 am - 8:55 pm
CHS
-
LIM
14h 25m
2 stops
LATAM Airlines Logo
8:55 am - 11:57 pm
LIM
-
CHS
14h 02m
2 stops
$689LATAM Airlines
Booking Insights

KAYAK's insights & trends for Charleston to South America flights

Get data-powered insights and trends into flights from Charleston to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Charleston to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Charleston to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Charleston to South America is September, when tickets cost $633 (return) on average. On the other hand, the most expensive months are November and June, when the average cost of round-trip tickets is $932 and $881 respectively.

Good to know

Low seasonOctober
Cheapest flight$125
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly and prices are also 2% lower on average.
Flight from Charleston to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Charleston to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Charleston to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Charleston to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Charleston to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Charleston to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Charleston to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Charleston to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Charleston to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Charleston to South America

 
Need help choosing which airline to fly with from Charleston to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8292 reviews
7.9Comfort
7.2Food
8.5Crew
8.1Boarding
7.8Entertainment
Airline reviews

First class is comfortable. Enjoyed a movie and was able to relax compared to coach.

10.0 ExcellentAnonymous, Mar 2026
ATL - DTW
Read more Delta reviews

First class is comfortable. Enjoyed a movie and was able to relax compared to coach.

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

The WiFi was not working. That made for a long flight.

With Aeromexico it ended up good but with Delta it was bad because we did everything through Delta... Showed up at the Delta terminal... It was the wrong place! Nothing ever told us to go to the Aeromexico terminal. It said "in partnership with Aeromexico" but I was never instructed to check in with them or go to their terminal. We had to haul @$$ running through the airport and almost didn't make it thanks to this poor communication. 👎🏽

Absolutely no communication on why there's a delay and multiple flight time reschedules. I would have canceled the flight and drove back home if I known it was going to be rescheduled 3 or 4 times.

Another late night flight and MORE men belligerently drinking and yelling. I had to move from first to economy because they were so obnoxious and disruptive. Crazy to go from a cozy chair to cardboard when you were supposed to be in first. Delta allows was too much drinking which leads to belligerent behavior.

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Love delta smaller commuter plane so no entertainment and paid wifi on MKE-LGA leg was extremely unreliable and slow

Stop changing gates. Stop cancelling flights Stop moving my seat.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

We were not allowed to carry a bottle of water onto the 8 hour flight.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

The way the Pilot made all announcements, specially the way he congratulated the entire crew as the best team ever, making a comment that due to them they were able to shorter the delay to the destination. Amazing flight .

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

Easy boarding. Rows are smaller but that may be an older and bigger me now :)

It would have been nice if American tried to care.

American Airlines did everything they could with the high Spring Break crowd. I was frustrated to be changed from 1st class to a middle seat at the back of the plane. This has happened before, not sure booking 1st class and paying the extra actually works.

I booked 1st class, my flights were changed and I was sitting in the middle at the back of the plane. A far cry from the 1st class I purchased for my flights. I am grateful I arrived on time.

Aging planer and NO wifi on a 14 hour day flight. Unless you are retired or don't need to work or be in touch with the world... The lack of Wifif really ruined the flight. And the old plane - really showing it's age, wasn't great

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Our flight was delayed 3 times and this is why I am giving such low reviews. Everything else was okay but being in the airport at 4:30pm for my initial flight at 7pm to not leave until after 9:30pm is insane,

Flights were constantly delayed. CRW took 50 minutes to get bags

Flight has been delayed every time I've ever taken it. Seats uncomfortable. Children behind me yelling the entire flight. Some of this is out of their control but overall just consistently not a great experience.

Everything you need to know for your flight to South America

Information on your arrival and departure airports