$108 Find Cheap Flights from Charleston to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Charleston to South America departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Flight Deals

Cheap Flights from Charleston to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$499
Bogotá
Bogotá1 stop$304
Sao Paulo
Sao Paulo2 stops$754
Santiago
Santiago1 stop$783
Cartagena
Cartagena1 stop$371
Quito
Quito2 stops$432
Guayaquil
Guayaquil1 stop$261
Cusco
Cusco2 stops$899
Montevideo
Montevideo2 stops$1,131
Lima
Lima1 stop$499
Bogotá
Bogotá1 stop$304
Sao Paulo
Sao Paulo2 stops$754
Santiago
Santiago1 stop$783
Cartagena
Cartagena1 stop$371
Quito
Quito2 stops$432
Guayaquil
Guayaquil1 stop$261
Cusco
Cusco2 stops$899
Montevideo
Montevideo2 stops$1,131

Book Cheap Charleston to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Charleston to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Charleston to South America

Thu, Mar 5 - Sun, Mar 8
Spirit Airlines Logo
6:35 pm - 12:04 am
CHS
-
GYE
29h 29m
1 stop
Spirit Airlines Logo
11:59 pm - 5:40 pm
GYE
-
CHS
16h 41m
1 stop
$261Spirit Airlines
Thu, Mar 26 - Mon, Mar 30
Spirit Airlines Logo
8:07 am - 1:22 pm
CHS
-
MDE
6h 15m
1 stop
Spirit Airlines Logo
2:17 pm - 10:33 pm
MDE
-
CHS
7h 16m
1 stop
$271Spirit Airlines
Tue, Feb 10 - Mon, Feb 23
Multiple Airlines Logo
3:01 pm - 12:50 pm
CHS
-
BOG
21h 49m
1 stop
Multiple Airlines Logo
1:45 pm - 8:38 am
BOG
-
CHS
18h 53m
1 stop
$304Multiple Airlines
Tue, Feb 10 - Mon, Feb 23
Multiple Airlines Logo
3:01 pm - 12:50 pm
CHS
-
BOG
21h 49m
1 stop
Multiple Airlines Logo
1:45 pm - 4:05 pm
BOG
-
CHS
26h 20m
2 stops
$323Multiple Airlines
Sat, Apr 4 - Fri, Apr 10
United Airlines Logo
5:12 pm - 5:00 am
CHS
-
UIO
12h 48m
1 stop
United Airlines Logo
12:35 am - 5:13 pm
UIO
-
CHS
15h 38m
2 stops
$619United Airlines
Sat, Apr 4 - Fri, Apr 10
United Airlines Logo
5:12 pm - 5:00 am
CHS
-
UIO
12h 48m
1 stop
United Airlines Logo
12:35 am - 5:13 pm
UIO
-
CHS
15h 38m
2 stops
$665United Airlines
Mon, May 4 - Tue, May 19
American Airlines Logo
8:09 pm - 10:10 am
CHS
-
CUZ
15h 01m
2 stops
American Airlines Logo
4:35 pm - 10:24 am
CUZ
-
CHS
16h 49m
2 stops
$930American Airlines
Fri, May 1 - Sun, May 10
American Airlines Logo
11:04 am - 7:20 am
CHS
-
CUZ
21h 16m
2 stops
American Airlines Logo
9:45 pm - 7:41 pm
CUZ
-
CHS
20h 56m
2 stops
$949American Airlines
Wed, May 27 - Tue, Jun 9
LATAM Airlines Logo
12:15 pm - 5:40 am
CHS
-
GRU
16h 25m
1 stop
LATAM Airlines Logo
8:15 am - 11:57 pm
GRU
-
CHS
16h 42m
2 stops
$1,046LATAM Airlines
Wed, May 27 - Tue, Jun 9
LATAM Airlines Logo
12:15 pm - 8:50 am
CHS
-
GRU
19h 35m
2 stops
LATAM Airlines Logo
8:15 am - 11:57 pm
GRU
-
CHS
16h 42m
2 stops
$1,051LATAM Airlines
Booking Insights

KAYAK's insights & trends for Charleston to South America flights

Get data-powered insights and trends into flights from Charleston to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Charleston to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Charleston to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Charleston to South America is April, when tickets cost $535 (return) on average. On the other hand, the most expensive months are November and December, when the average cost of round-trip tickets is $891 and $874 respectively.

Good to know

Low seasonOctober
Cheapest flight$108
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 7% lower on average.
Flight from Charleston to Medellín

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Charleston to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Charleston to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Charleston to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Charleston to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Charleston to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Charleston to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Charleston to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Charleston to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Charleston to South America

 
Need help choosing which airline to fly with from Charleston to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8124 reviews
8.1Boarding
7.9Comfort
8.5Crew
7.2Food
7.8Entertainment
Airline reviews

The flight was comfortable and uneventful, which is what I desire

8.0 ExcellentLarry, Jan 2026
JFK - SJD
Read more Delta reviews

The flight was comfortable and uneventful, which is what I desire

The service from the flight attendants were of supreme quality. They greeted and treated everyone with a wide smile. This is totally absent nowadays. Kudos to them!!!!

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Very large passenger too space from my own seat. Arm board couldn’t be lowered because of his size. It wads very uncomfortable trip, as the flight was full couldn’t move anywhere having back pain because of the position in which I was the entire flight.

was sitting in the jet bridge for 10 minutes in -20 degree weather waiting for my bag

Outdated equipment in disrepair, wifi inoperable. Broken seats, taped air vents, generally poor condition, the 717 showed its age and lack of upkeep.

My flight out of Baton Rouge to Atlanta was delayed by a half hour. This got us into Atlanta airport 30 minutes late. I ran through the airport to get to my connecting flight. As I approached the boarding gate, I saw the boarding door was still open and a passenger was being checked in. But when I got to the gate, the boarding agent told me they had already given away my seat and there were no empty seats on that flight. So I had to take a later flight. That has never happened to me before. Very frustrating.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

The flight was delayed and oversold. I volunteered to give up my seat for compensation. Thinking I could get a good night's sleep instead of arriving home at 2 am. It took over an hour to get the new reservation confirmed, three different gate attendants, and two red coats. It took even longer to confirm the overnight hotel, and when I arrived, the line was 45 minutes long, with two people checking in, and at least 15 people slowly, very slowly—no food except frozen convenience food, no coupon for food from airlines. Slept, headed back to the airport, and that flight had an equipment change and a gate change just as they were about to board. It took an additional hour to board as they cleaned the plane from storage.

We were not allowed to carry a bottle of water onto the 8 hour flight.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

I like this airline a lot no problems at all, except being forced to check a carry-on bag ., Overall very good airline

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

The way the Pilot made all announcements, specially the way he congratulated the entire crew as the best team ever, making a comment that due to them they were able to shorter the delay to the destination. Amazing flight .

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

Just to drop my already labeled bag it took 50 minutes inline. Completely disappointed with Latam operation at GRU

Really bad experience – delayed for 6 hours without any notice, no food or drinks provided, and stuck in the horrible Cartagena airport.

I’m entitled to a refund per LATAM due to the mid flight itinerary change and being stuck in São Paulo for 24 hours and needing to get a hotel. The airline was dismissive and of no help.

The plane was experiencing problems with the HVAC system, it was very cold in the front of the plane and very hot in the back.

My flight to London from Philadelphia was cancelled due to weather.

The attendants were kind and helpful. A sugar-free drink would have been very welcome.

Pilot navigated severe weather/snow storm with skill. Described his intentions clearly

one crew said "he" didn't serve double alcohol drinks for travelers in exit rows. crew on prior flight did. Is this a AA rule, and the prior crew was being nice? Also, I think we deserve more than a 25% refund for losing first class seats when rescheduling a flight due to weather

It was a little concerning to hear the ground crew arguing with the flight crew over baggage space. Instead of taking them and checking them, they started checking for space in the first class cabin moving items around like the flight crew didn't know what they were doing. I was embarrassed for them.

2 hour delay due to equipment failure. No updates via the app and airport screens (which continued to show a departure time in the past). AA eventually switched planes and the new plane was not catered or cleaned correctly.

I booked an aisle seat and was given a middle. At 6'4" 230lbs, it is not ideal to fly in the middle row for myself and passengers.

Trip delayed for 2 hours because of rain. We boarded and have to get down the flight and reboard again.

The aircraft had several problems - from excess fuel to non operational ac. Two hours of delay in Chicago could have been avoided with proper planning and aircraft maintenance.

Everything you need to know for your flight to South America

Information on your arrival and departure airports