COU - TYS

$308 Find Cheap Flights from Columbia to Knoxville - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$308
Typical prices: $348-$541
American Airlines
Sun 12/9Thu 12/13
COU - TYS • 1 stop
Cheapest one-way
$343
Typical prices: $258-$403
Multiple Airlines
Mon 11/19
COU - TYS • 2 stops
When to travel
November
Cheapest • 33% price drop
October
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Chicago O'Hare Intl (ORD)
Cheapest • Avg $397 (round-trip)
Charlotte Douglas (CLT)
Shortest trip • 4h 40m (one-way)
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Flight Deals

Cheap Flights from Columbia to Knoxville (COU-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Columbia to Knoxville

Wed, Dec 9 - Sun, Dec 13
American Airlines Logo
8:12 am - 3:26 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
6h 14m1 stop Charlotte Douglas
American Airlines Logo
5:13 pm - 10:17 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
6h 04m1 stop Chicago O'Hare Intl
$308American Airlines
Tue, Dec 1 - Tue, Dec 8
American Airlines Logo
5:08 pm - 11:32 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
5h 24m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 11:39 amTYS  Knoxville McGhee Tyson-COU Columbia Regional
7h 09m1 stop Dallas/Fort Worth
$308American Airlines
Wed, Nov 18 - Sat, Dec 5
American Airlines Logo
6:47 am - 2:05 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
6h 18m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 11:35 amTYS  Knoxville McGhee Tyson-COU Columbia Regional
7h 05m1 stop Dallas/Fort Worth
$323American Airlines
Tue, Dec 1 - Tue, Dec 8
United Airlines Logo
3:04 pm - 11:59 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
7h 55m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
6:00 am - 10:35 amTYS  Knoxville McGhee Tyson-COU Columbia Regional
5h 35m1 stop Chicago O'Hare Intl
$330United Airlines
Fri, Nov 13 - Tue, Nov 17
American Airlines Logo
6:26 pm - 11:47 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
4h 21m1 stop Chicago O'Hare Intl
American Airlines Logo
11:33 am - 5:52 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
7h 19m1 stop Chicago O'Hare Intl
$338American Airlines
Tue, Nov 17 - Sat, Nov 21
American Airlines Logo
5:11 pm - 11:32 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
5h 21m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 11:35 amTYS  Knoxville McGhee Tyson-COU Columbia Regional
7h 05m1 stop Dallas/Fort Worth
$338American Airlines
Tue, Nov 17 - Sat, Nov 21
United Airlines Logo
3:00 pm - 11:59 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
7h 59m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
6:45 am - 10:45 amTYS  Knoxville McGhee Tyson-COU Columbia Regional
5h 00m1 stop Chicago O'Hare Intl
$344United Airlines
Fri, Feb 19 - Sun, Feb 21
American Airlines Logo
5:35 pm - 11:53 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
5h 18m1 stop Dallas/Fort Worth
American Airlines Logo
2:52 pm - 7:22 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
5h 30m1 stop Dallas/Fort Worth
$353American Airlines
Fri, Nov 13 - Mon, Nov 16
American Airlines Logo
6:26 pm - 11:47 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
4h 21m1 stop Chicago O'Hare Intl
American Airlines Logo
4:59 pm - 10:15 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
6h 16m1 stop Chicago O'Hare Intl
$358American Airlines
Sat, Feb 6 - Tue, Feb 9
United Airlines Logo
11:36 am - 4:54 pmCOU  Columbia Regional-TYS Knoxville McGhee Tyson
4h 18m1 stop Chicago O'Hare Intl
United Airlines Logo
5:55 pm - 11:30 pmTYS  Knoxville McGhee Tyson-COU Columbia Regional
6h 35m1 stop Chicago O'Hare Intl
$398United Airlines
Booking Insights

Price, demand and travel trends for Columbia to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Columbia to Knoxville?

Round-trip flights from Columbia to Knoxville typically range from $348 to $541. The lowest price found in the past 5 days was $308, on American Airlines.

What's the cheapest day of the week to fly from Columbia to Knoxville?

Based on deals KAYAK users found in the last 12 months, Wednesday is the cheapest day of the week to fly from Columbia to Knoxville. It’s 38% cheaper than the average day, while Monday is the most expensive, with prices 53% higher.

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Key details for Columbia to Knoxville flights

Low season

January

Cheapest flight

$308
Beat the crowds with an average 92% drop in travelers.
The most popular month to fly with an average 82% increase in travelers.
Round-trip flight from Columbia to Knoxville

When to book flights from Columbia to Knoxville

Are your dates flexible? Find out the best times to travel from Columbia to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Columbia to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Columbia to Knoxville?

    Two cabin classes are available on flights from Columbia to Knoxville:

    • Economy Class
    • First Class

  • How long is a flight from Columbia to Knoxville?

    There are currently no nonstop flights available from Columbia to Knoxville. Flights with 1 layover take between 4h 40m and 5h 29m in total, depending on the connection.

  • Do I need a passport to fly from Columbia to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Columbia to Knoxville flight?

    Round-trip flights from Columbia to Knoxville range from $348 to $541, with an average of $461 over the past 12 months. Anything below $348 counts as a good deal.

  • Have flight prices from Columbia to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $308 to $1,399. That means the highest observed fare was about 5x higher than the lowest one.

  • How are flight prices from Columbia to Knoxville looking right now?

    One-way fares from Columbia to Knoxville are currently higher than usual. Average one-way flight prices are about $352, which is 33% above the typical average for this route.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from Columbia to Knoxville?

    Flights from Columbia to Knoxville usually depart from Columbia Regional (COU) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Columbia to Knoxville pass through?

    One-stop flights from Columbia to Knoxville most commonly connect through:

    • Chicago O'Hare Intl (ORD) - 68% of one-stop connections
    • Dallas/Fort Worth (DFW) - 21% of one-stop connections
    • Charlotte Douglas (CLT) - 11% of one-stop connections

  • Can I save money by using flexible dates for flights from Columbia to Knoxville?

    Yes. Flexible dates can save you up to 60% on flights from Columbia to Knoxville. Wednesday is the cheapest departure day at $288 round-trip on average, while Monday is the most expensive at $707, a difference of $419.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Columbia to Knoxville?

    Flying via Charlotte Douglas (CLT) gives the shortest average 1-stop total travel time at 4h 40m, compared with 4h 50m via Chicago O'Hare Intl (ORD) and 5h 29m via Dallas/Fort Worth (DFW).

  • What is the time difference between Columbia and Knoxville?

    Knoxville is 1 hour ahead of Columbia (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Columbia to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Wednesday departure and avoid flying on Monday. On this route, Wednesday flights average $288, about $419 less than Monday fares (59% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Columbia to Knoxville trip for November. Fares historically average $308 round-trip in that month - typically $440 less than the most expensive month, which is February (based on the last 12 months).

More options for your flight from Columbia to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Car rentals in Knoxville
Hotels in Knoxville
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