$137 Find Cheap Flights from Columbus to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Columbus to South America departing on 12/7. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Columbus to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$430
Bogotá
Bogotá1 stop$304
Buenos Aires
Buenos Aires3 stops$985
Sao Paulo
Sao Paulo3 stops$896
Rio de Janeiro
Rio de Janeiro3 stops$787
Santiago
Santiago3 stops$740
Cartagena
Cartagena1 stop$310
Quito
Quito3 stops$591
Guayaquil
Guayaquil1 stop$341
Cali
Cali1 stop$394
Cusco
Cusco2 stops$863
Georgetown
Georgetown1 stop$642
Lima
Lima1 stop$430
Bogotá
Bogotá1 stop$304
Buenos Aires
Buenos Aires3 stops$985
Sao Paulo
Sao Paulo3 stops$896
Rio de Janeiro
Rio de Janeiro3 stops$787
Santiago
Santiago3 stops$740
Cartagena
Cartagena1 stop$310
Quito
Quito3 stops$591
Guayaquil
Guayaquil1 stop$341
Cali
Cali1 stop$394
Cusco
Cusco2 stops$863
Georgetown
Georgetown1 stop$642

Book Cheap Columbus to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Columbus to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Columbus to South America

Mon, Jan 26 - Thu, Jan 29
Spirit Airlines Logo
6:15 am - 1:15 pmCMH-CTG
7h 00m1 stop
Spirit Airlines Logo
2:21 pm - 10:13 pmCTG-CMH
7h 52m1 stop
$310Spirit Airlines
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Mon, Jan 26 - Mon, Feb 2
Spirit Airlines Logo
6:15 am - 1:15 pmCMH-CTG
7h 00m1 stop
Spirit Airlines Logo
2:21 pm - 10:13 pmCTG-CMH
7h 52m1 stop
$312Spirit Airlines
Find Deal
Tue, Jan 6 - Wed, Jan 28
Spirit Airlines Logo
11:14 am - 1:28 amCMH-MDE
14h 14m1 stop
Spirit Airlines Logo
2:50 pm - 11:58 pmMDE-CMH
9h 08m1 stop
$315Spirit Airlines
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Thu, Mar 12 - Mon, Mar 23
Delta Logo
1:01 pm - 7:40 amCMH-SCL
17h 39m1 stop
Delta Logo
6:30 pm - 12:04 pmSCL-CMH
18h 34m2 stops
$764Delta
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Wed, Dec 24 - Mon, Jan 19
LATAM Airlines Logo
6:00 am - 5:35 amCMH-SCL
21h 35m2 stops
LATAM Airlines Logo
9:30 pm - 9:55 amSCL-CMH
14h 25m1 stop
$769LATAM Airlines
Find Deal
Thu, Mar 12 - Sun, Mar 22
LATAM Airlines Logo
1:00 pm - 2:05 pmCMH-SCL
24h 05m2 stops
LATAM Airlines Logo
6:52 pm - 11:44 amSCL-CMH
41h 52m3 stops
$794LATAM Airlines
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Sat, Dec 6 - Wed, Dec 10
Delta Logo
12:26 pm - 6:35 amCMH-SCL
16h 09m2 stops
Delta Logo
11:30 pm - 5:36 pmSCL-CMH
20h 06m1 stop
$804Delta
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Mon, Feb 23 - Wed, Feb 25
Air Canada Logo
9:30 am - 9:00 amCMH-GRU
21h 30m1 stop
Air Canada Logo
9:30 pm - 8:56 pmGRU-CMH
25h 26m1 stop
$939Air Canada
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Fri, May 1 - Fri, May 15
Air Canada Logo
2:15 pm - 8:15 pmCMH-SDU
29h 00m2 stops
Air Canada Logo
1:45 pm - 3:28 pmSDU-CMH
26h 43m2 stops
$1,269Air Canada
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Wed, Feb 4 - Sun, Feb 15
United Airlines Logo
8:05 pm - 2:20 pmCMH-SDU
16h 15m2 stops
United Airlines Logo
2:50 pm - 9:41 amSDU-CMH
20h 51m2 stops
$1,346United Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Columbus to South America flights

Get data-powered insights and trends into flights from Columbus to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Columbus Airport to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Columbus Airport to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Columbus Airport to South America is January, when tickets cost $707 (return) on average. On the other hand, the most expensive months are June and December, when the average cost of round-trip tickets is $982 and $927 respectively.

What’s the cheapest day of the week to fly from Columbus to South America?

The average price of all round-trip flights from Columbus Airport to South America clicked on KAYAK for each day over the last 12 months.

When flying from Columbus to South America, you should consider leaving on a Wednesday and avoid Saturdays if you are looking for the best rates. For your return to Columbus, you’ll find the best rates on Sundays and the most expensive ones on Fridays.

How far in advance should I book a flight from Columbus Airport to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Columbus Airport to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Columbus Airport to South America, you should book around 5 weeks before departure, which saves you about 35% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 15 weeks before departure.

Good to know

Low seasonOctober
Cheapest flight$137
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 31% increase in price.
Flight from Columbus to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Columbus to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Columbus to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Columbus to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Columbus to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Columbus to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Columbus to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Columbus to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Columbus to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the afternoon, when round-trip flights cost $818 on average. Morning departures are around 2% more expensive than evening flights, on average. The most expensive time of day to fly to South America is generally at night, which is peak travel time and where the average cost of a ticket is $851.

Reviews of the top 5 airlines serving from Columbus to South America

 
Need help choosing which airline to fly with from Columbus to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7996 reviews
8.1Boarding
7.9Entertainment
8.5Crew
7.3Food
7.9Comfort
Airline reviews

Great. Seamless. Check in agent at kiosk international was amazing and extremely helpful.

10.0 ExcellentWilliam, Nov 2025ATL - SJO
Read more Delta reviews

Great. Seamless. Check in agent at kiosk international was amazing and extremely helpful.

Our flight from SFO to MSP was right on time on 11/15/2025. No delays. As we approached MSP at about 8 pm, we circled in the air until 8:40 pm so I don't call that efficient for MSP. I think the captain should announce the delay and why. (as if we all don't know that we are just circling around the area, slowing down, speeding up, slowing down.) Thank you. Marilyn Fischer

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

Plenty of leg room, temperature was great and staff was excellent. Would do it more often.

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

Flight delayed then cancelled. Misplaced luggage. Still do not have. Rented car 1100 mile drive. I had to buy some overnight Hotels clothes toiletries gas food at my expense. Still not home. Not sure where luggage is. Over 4 hours on hold to Felta

I truly love flying with Delta. They have always treated me with the upmost respect

Our flight attendant in FIRST CLASS was one of the worst I’ve ever had. She was not at all pleasant, nor particularly good at her service.

Everything went well and was good. Nothing exceptional, but no complaints either. Cheap seats are pretty comfortable.

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

Boarding was confusing with a delayed flight because there was no English translation

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

Very nice flight love the small aircraft. We had a wonderful flight attendant. Nice to see someone that really enjoys her job. Don't have her name but had a southern accent.

This was an older airplane. The cabin was constantly warm to hot throughout the 10 hour flight and there were no vents to personalize air flow. Also since it was an older plane, the material and comfort of the chairs were very uncomfortable. I left my flight with major soreness on my tailbone.

Very thoughtful flight attendant offered me water immediately since I had run to make my connection.

Door to door, the crew and staff were amazing. It was a stressful travel day with delays, but they were focused on customers and doing what they could to get us to our destinations.

Even though we were delayed, we were able to make our connection

Seats in waiting area and on plane hard as rock. Fast internet on the flight was great! Crew was kind.

Starlink wifi on the Embraer E175 is an excellent experience. I was able to connect and work from IAD all the way to approach into BTV.

Older aircraft, no meal, only food was for purchase. Not impressed United.

United needs to step up their game. Delayed flight leaving Seattle, San Francisco. Older aircraft, not very comfortable.

Always wish for more healthy, gluten free options. We have to bring our own.

I had a positive experience on American. I'm blind and traveling with a guide dog and the flight attendants were so kind, friendly, and helpful towards us. They checked in on us during the flight and they made us feel comfortable and welcomed. There was an hour delay before depature, but overall the flight was a smooth ride. I appreciate that there were no issues on this long flight back home.

We were told the flight was delayed 5 times, then it was moved to the next day.

More choices on snacks. Built-in video screen to enjoy entertainment choices.

we landed at cmh ten minutes early but had to sit on tarmac for twenty minutes because a plane was at our gate despite the fact that 3 other gates were open.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

I have a gluten allergy so did have any food

I have a gluten allergy so didn't have any food

Loved the crew . Absolutely no complaints. Except for luggage lost

Everything was good The connects, with no blame to crew. Or pilots. I understand they are short staffed. Everything went well for me. I'll be using you guys again in May if not sooner.

this plane was really old, had exit row seats and tray was in arm of seat so super uncomfortable to use. another seat they could t even use the tray it was broke. seat i. front of me had duct tape on it cause seat was ripped open... this plane should either be updated or retired.

Speaker airport didn't work well, so we couldn't hear the boarding call but the plane was on time leaving and on time arriving took a while for them to open the door and there was a non-disruptive guy who was inebriated a few rows ahead of us. Overall the flight was good and we appreciate the on-time-ness

The plane was freezing and everyone had on their winter coats. I pulled out my sweaters out of my carryon to cover myself and put on an extra pair of socks. They offered NO FREE drinks or snacks on a 6 hour flight. The seats don’t have plugs or charges or any form of entertainment- so I just played my one downloaded game on my phone because I couldn’t sleep because I was too cold. Miserable flight though we landed safely.

Bought round trip tickets. Ended up upgrading to first class. Both flights were new planes but hadn’t been equipped with WiFi and there were no charging ports at my seat despite it being new and first class accommodations.

The flight was on time and the crew was very professional and accommodating. When other airlines are canceling flights Spirit is still flying with on time flights. I have no complaints and will continue to choose Spirit when it is the best option for me.

Very uncomfortable seat. Hard bar under cushion. Flight had no solution except to walk a around at times

Endless, trip oof my life, we still are in in plane waiting for getting off.after 3 hours delay. Not even a glass of water.

It was cheap. Spirit is what it is. I got to my destination and home safely. There was no food or entertainment without paying extra, which is fine. That’s why the flight was inexpensive.

Like: seats that don't move; fast boarding; engaging crew; low-prices; individual gate at LGA; access to restrooms at the gate Dislike: no water on the flight

No leg room. My knee was sore for a day.

It was better than expected. But there were two delays in taking off.

Everything you need to know for your flight to South America

Information on your arrival and departure airports