$120 Find Cheap Flights from Columbus to South America

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Columbus to South America departing on 1/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Cheap Flights from Columbus to South America

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Lima
Lima1 stop$416
Bogotá
Bogotá1 stop$315
Buenos Aires
Buenos Aires3 stops$844
Sao Paulo
Sao Paulo2 stops$684
Rio de Janeiro
Rio de Janeiro3 stops$708
Santiago
Santiago3 stops$691
Cartagena
Cartagena1 stop$310
Quito
Quito2 stops$692
Guayaquil
Guayaquil1 stop$349
Cali
Cali1 stop$394
Cusco
Cusco2 stops$1,130
Georgetown
Georgetown1 stop$756
Asuncion
Asuncion2 stops$1,037
Lima
Lima1 stop$416
Bogotá
Bogotá1 stop$315
Buenos Aires
Buenos Aires3 stops$844
Sao Paulo
Sao Paulo2 stops$684
Rio de Janeiro
Rio de Janeiro3 stops$708
Santiago
Santiago3 stops$691
Cartagena
Cartagena1 stop$310
Quito
Quito2 stops$692
Guayaquil
Guayaquil1 stop$349
Cali
Cali1 stop$394
Cusco
Cusco2 stops$1,130
Georgetown
Georgetown1 stop$756
Asuncion
Asuncion2 stops$1,037

Book Cheap Columbus to South America Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Columbus to South America that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Columbus to South America

Mon, Feb 2 - Thu, Feb 5
Spirit Airlines Logo
5:45 am - 2:15 pmCMH-MDE
8h 30m1 stop
Spirit Airlines Logo
3:15 pm - 11:27 pmMDE-CMH
8h 12m1 stop
$280Spirit Airlines
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Mon, Jan 26 - Wed, Jan 28
Spirit Airlines Logo
5:45 am - 2:15 pmCMH-MDE
8h 30m1 stop
Spirit Airlines Logo
3:15 pm - 11:27 pmMDE-CMH
8h 12m1 stop
$305Spirit Airlines
Find Deal
Mon, Jan 26 - Thu, Jan 29
Spirit Airlines Logo
5:45 am - 1:15 pmCMH-CTG
7h 30m1 stop
Spirit Airlines Logo
2:21 pm - 11:27 pmCTG-CMH
9h 06m1 stop
$310Spirit Airlines
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Tue, May 12 - Tue, May 19
United Airlines Logo
6:45 am - 11:42 pmCMH-GYE
17h 57m2 stops
United Airlines Logo
12:20 pm - 10:06 pmGYE-CMH
32h 46m2 stops
$626United Airlines
Find Deal
Mon, Mar 2 - Wed, Mar 11
Air Canada Logo
9:30 am - 9:00 amCMH-GRU
45h 30m2 stops
Air Canada Logo
9:15 pm - 8:56 pmGRU-CMH
24h 41m2 stops
$684Air Canada
Find Deal
Mon, Mar 2 - Wed, Mar 11
Air Canada Logo
9:30 am - 9:00 amCMH-GRU
21h 30m1 stop
Air Canada Logo
9:30 pm - 8:56 pmGRU-CMH
24h 26m1 stop
$759Air Canada
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Mon, Mar 23 - Wed, Apr 8
LATAM Airlines Logo
6:00 pm - 5:00 pmCMH-AEP
22h 00m2 stops
LATAM Airlines Logo
2:55 pm - 12:04 pmAEP-CMH
22h 09m2 stops
$1,070LATAM Airlines
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Mon, Jan 26 - Wed, Feb 11
LATAM Airlines Logo
6:01 pm - 10:15 amCMH-EZE
14h 14m1 stop
LATAM Airlines Logo
2:45 pm - 5:39 pmEZE-CMH
28h 54m2 stops
$1,094LATAM Airlines
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Tue, Jan 27 - Sun, Feb 8
Delta Logo
2:08 pm - 10:15 amCMH-EZE
18h 07m2 stops
Delta Logo
4:05 am - 12:04 amEZE-CMH
21h 59m2 stops
$1,106Delta
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Sun, Jan 25 - Tue, Feb 10
United Airlines Logo
4:41 pm - 7:20 amCMH-EZE
36h 39m1 stop
United Airlines Logo
11:55 pm - 10:29 pmEZE-CMH
24h 34m1 stop
$1,113United Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Columbus to South America flights

Get data-powered insights and trends into flights from Columbus to South America to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Columbus Airport to South America?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Columbus Airport to South America, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Columbus Airport to South America is January, when tickets cost $707 (return) on average. On the other hand, the most expensive months are June and December, when the average cost of round-trip tickets is $982 and $927 respectively.

What’s the cheapest day of the week to fly from Columbus to South America?

The average price of all round-trip flights from Columbus Airport to South America clicked on KAYAK for each day over the last 12 months.

When flying from Columbus to South America, you should consider leaving on a Wednesday and avoid Saturdays if you are looking for the best rates. For your return to Columbus, you’ll find the best rates on Sundays and the most expensive ones on Fridays.

How far in advance should I book a flight from Columbus Airport to South America?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Columbus Airport to South America, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Columbus Airport to South America, you should book around 5 weeks before departure, which saves you about 35% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 15 weeks before departure.

Good to know

Low seasonOctober
Cheapest flight$120
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly with an average 32% increase in price.
Flight from Columbus to Medellín Jose Maria Cordova Intl

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from Columbus to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Columbus to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Columbus to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Columbus to South America is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Columbus to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Columbus to South America with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Columbus to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Columbus to South America up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South America?

    The cheapest time of day to fly to South America is generally in the afternoon, when round-trip flights cost $818 on average. Morning departures are around 2% more expensive than evening flights, on average. The most expensive time of day to fly to South America is generally at night, which is peak travel time and where the average cost of a ticket is $851.

Reviews of the top 5 airlines serving from Columbus to South America

 
Need help choosing which airline to fly with from Columbus to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8011 reviews
7.3Food
8.5Crew
7.9Comfort
8.1Boarding
7.9Entertainment
Airline reviews

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

10.0 ExcellentHartaj, Nov 2025LGA - RDU
Read more Delta reviews

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

Staff was exceptional! Everyone was kind, professional and friendly making the trip very pleasant. Thank you!

No lunch on a x-country flight scheduled for 10:50 am departure, arrived 5+ hrs later. That requires a black box label before you pay for the tickets. Worst, when I checked in online, it's specifically said that lunch was served on his flight for economy Plus passengers.

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

It would’ve been nice for all that money to have a more substantial snack for free. I remember once upon a time getting a very nice turkey sandwich with Swiss cheese on whole wheat bread for no charge along with a drink. I guess those days are gone. it’s a little insulting being given a cookie or a bag of baked chips Going forward I’ll just bring my own.

Great. Seamless. Check in agent at kiosk international was amazing and extremely helpful.

Our flight from SFO to MSP was right on time on 11/15/2025. No delays. As we approached MSP at about 8 pm, we circled in the air until 8:40 pm so I don't call that efficient for MSP. I think the captain should announce the delay and why. (as if we all don't know that we are just circling around the area, slowing down, speeding up, slowing down.) Thank you. Marilyn Fischer

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

we were missing our luggage, trying to find someone to have any empathy was pretty much not happening....

Poor handling of carry on luggage. We had a 8 hour stop in Santiago, are over 70 and, in spite of paying full fare they wanted to send carry on to luggage hold. No empathy. We had to show that several group 4/5 passengers were not sending their carry ons before they finally let Is keep them. Very poor .

The flight was late. Please do not delay next time.

I couldn't travel, now I can't get a refund and to change the date I have to pay an absurd fine.

Boarding was confusing with a delayed flight because there was no English translation

My biggest complaint is the comfort. I am not tall and there was no legroom. It was very uncomfortable. During my transfer in Sao Paola, the flight was slightly delayed so boarding was confusing because there were no instructions in English.

I never got this flight. You sent me to Chile!!! And from Chile I got the other flight to São Paulo... I've arrived 7h latter than I was supposed to arrive because of Delta delays.

Because the flight was late, we lost the connection to Brazil. You, Delta delayed, and you Delta anticipated the door closing in 15 min from Miami to GRU. Why? It caused a lot of stress! I almost could not see my mother in law alive because of your delay.

Seats had less pitch than a regional jet. Food was OK. Have to buy alcohol on US based carriers flying international. Boarding was a mess. Did not have bags but overhead space was gone quick. Would like to see the airlines enforce the one bag over and one bag under policy

Ot was overall fine. Left on time and had basic snacks. Weather was finicky but that’s not the airlines fault.

from SFO-> FRA flight, AVML meal was significantly less compared to regular meal, especially no Desert, no Bread, no sides.

Very nice flight love the small aircraft. We had a wonderful flight attendant. Nice to see someone that really enjoys her job. Don't have her name but had a southern accent.

This was an older airplane. The cabin was constantly warm to hot throughout the 10 hour flight and there were no vents to personalize air flow. Also since it was an older plane, the material and comfort of the chairs were very uncomfortable. I left my flight with major soreness on my tailbone.

Very thoughtful flight attendant offered me water immediately since I had run to make my connection.

Door to door, the crew and staff were amazing. It was a stressful travel day with delays, but they were focused on customers and doing what they could to get us to our destinations.

Even though we were delayed, we were able to make our connection

Seats in waiting area and on plane hard as rock. Fast internet on the flight was great! Crew was kind.

Starlink wifi on the Embraer E175 is an excellent experience. I was able to connect and work from IAD all the way to approach into BTV.

I like that the crew kept us informed but we moved back and forth from gate to gate before the aircraft arrived.

The flight was delayed multiple times, again no fault of American but again the extra cost, for everything makes it feel like a cheap airline! Especially when flights are outrageously expensive already

Horrible. Both legs of my flight were delayed more than 6 hours. No compensation, no screens on the plane, and the plane was not clean.

I had a positive experience on American. I'm blind and traveling with a guide dog and the flight attendants were so kind, friendly, and helpful towards us. They checked in on us during the flight and they made us feel comfortable and welcomed. There was an hour delay before depature, but overall the flight was a smooth ride. I appreciate that there were no issues on this long flight back home.

We were told the flight was delayed 5 times, then it was moved to the next day.

More choices on snacks. Built-in video screen to enjoy entertainment choices.

we landed at cmh ten minutes early but had to sit on tarmac for twenty minutes because a plane was at our gate despite the fact that 3 other gates were open.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

I have a gluten allergy so did have any food

I have a gluten allergy so didn't have any food

I didn't eat, so I can't rate the food. Delayed set off was beyond

No free snacks or drinks. Freezing. Uncomfortable. No plugs or entertainment. If you fly to LA the make you change terminals with a slow bus. Awful trip that took forever. Terrible airline- maybe the worst I’ve ever flown.

I hope you continue to be one of the great company

Crew are always very angry and dismissive like they seem they are being forced to work. In addition, there was a long line for the bathrooms, and only one was allowed to be used. No reason was given for only one bathroom being available; apparently, the stewardess was more interested in using the jumpseat instead of allowing the customers to use the bathroom.

Very positive in both directions. Safe travels, nice staff, lost and found in fact found my phone under my chair! I was out of cash after my NYC trip otherwise I would've offered a reward for helping my day out immensly! Thanks you so much Spirit staff!

I stopped flying spirit as much because they are crooks and thieves. It's not like other airlines where you can at least get credits they just take your money.

Flight was on time. Friendly crew. Gate agents in the other hand were very unfriendly.

Uncomfortable seats and tiny tray table. Expensive snacks. Flight was on time and crew was pleasant but take me back to Southwest!

Boarding and unboarding processes were pretty smooth. I gave a low score for Boarding because of how my flight was missing from all the boards at the airport, and when I checked the flight status on the Spirit website, it said it would be departing from Terminal E, gate D15. There are no "D" gates in terminal E.

Speaker airport didn't work well, so we couldn't hear the boarding call but the plane was on time leaving and on time arriving took a while for them to open the door and there was a non-disruptive guy who was inebriated a few rows ahead of us. Overall the flight was good and we appreciate the on-time-ness

Everything you need to know for your flight to South America

Information on your arrival and departure airports