DSM - GNV

$264 Find Cheap Flights from Des Moines to Gainesville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Gainesville departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Gainesville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Gainesville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Gainesville, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 22% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Gainesville (DSM-GNV)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Gainesville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Gainesville

Mon, Oct 6 - Mon, Oct 13
American Airlines Logo
6:22 pm - 12:17 amDSM-GNV
4h 55m1 stop
American Airlines Logo
1:46 pm - 5:42 pmGNV-DSM
4h 56m1 stop
$447American Airlines
Find Deal
Mon, Oct 6 - Mon, Oct 13
American Airlines Logo
3:56 pm - 12:17 amDSM-GNV
7h 21m2 stops
American Airlines Logo
1:46 pm - 5:42 pmGNV-DSM
4h 56m1 stop
$452American Airlines
Find Deal
Mon, Oct 6 - Mon, Oct 13
American Airlines Logo
5:00 am - 1:16 pmDSM-GNV
7h 16m2 stops
American Airlines Logo
1:46 pm - 8:11 pmGNV-DSM
7h 25m2 stops
$526American Airlines
Find Deal
Tue, Dec 23 - Sun, Dec 28
Delta Logo
6:37 pm - 11:53 pmDSM-GNV
4h 16m1 stop
Delta Logo
6:00 am - 10:39 amGNV-DSM
5h 39m1 stop
$592Delta
Find Deal
Tue, Dec 23 - Sun, Dec 28
Delta Logo
6:15 am - 2:21 pmDSM-GNV
7h 06m2 stops
Delta Logo
6:00 am - 10:39 amGNV-DSM
5h 39m1 stop
$797Delta
Find Deal

Everything you should know

Top airlines
American Airlines
Cheapest • from $447 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Cheapest round-trip
$447
American Airlines
Mon 10/6Mon 10/13
DSM - GNV • 1 stop
Cheapest one-way
$264
American Airlines
Thu 11/6
DSM - GNV • 1 stop
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Gainesville!
Booking Insights

KAYAK's insights & trends for Des Moines to Gainesville flights

Get data-powered insights and trends into flights from Des Moines to Gainesville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to Gainesville?

The average price of all round-trip flights from Des Moines to Gainesville clicked on KAYAK for each day over the last 12 months.

If you are looking for a flight deal from Des Moines to Gainesville, look for departures on Wednesdays and avoid leaving on a Friday, as it's usually the priciest day. When flying back from Gainesville, Saturday is the cheapest day to fly and Wednesday is the most expensive.

Find deals

Good to know

Cheapest flight$264
Flight from Des Moines to Gainesville

When to book flights from Des Moines to Gainesville

Are your dates flexible? Find out the best times to travel from Des Moines to Gainesville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Gainesville

  • What is the cheapest flight from Des Moines to Gainesville?

    In the last 3 days, the lowest price for a flight from Des Moines to Gainesville was $264 for a one-way ticket and $447 for a round-trip.

  • Do I need a passport to fly between Des Moines and Gainesville?

    A passport is not required to fly from Des Moines to Gainesville.

  • Which aircraft models fly most regularly from Des Moines to Gainesville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Gainesville?

    oneworld, and SkyTeam are the airline alliances operating flights between Des Moines and Gainesville, with SkyTeam being the most commonly used for this route.

  • How does KAYAK find such low prices on flights from Des Moines to Gainesville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Gainesville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Gainesville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Gainesville from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Gainesville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Gainesville with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and GNV can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Gainesville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Gainesville from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Des Moines to Gainesville

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Gainesville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Gainesville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7954 reviews
7.9Entertainment
7.3Food
8.5Crew
7.9Comfort
8.2Boarding
Airline reviews

Perfect flight both ways. On time, courteous staff, plane comfortable and cool. Best domestic flights I’ve had in awhile.

10.0 ExcellentAnonymous, Sep 2025CLT - BOS
Read more Delta reviews

Perfect flight both ways. On time, courteous staff, plane comfortable and cool. Best domestic flights I’ve had in awhile.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

Crew was good. The reservation got mixed up and they didn't have my TSA number. I am also a Silver Medallion and wasn't able to use Sky Priority.

Delta made it easy, comfortable and timely. The crew was fantastic.

This route with Delta always has delays or is cancelled. Aircrafts seem smaller and older. I fly Delta quite a bit - haven’t had issues with the international flights. But this route has always been the troublesome one

Three seats in first class were broken and while they were able to still acommodate us it was looking very touch and go and they had others they could not acommodate

Always good but we must do something about people in rows ahead of you that don't put their seats back up when they are suppose to. And It's rough to not be able to even lean over to get something out of my purse.

this crew didn't care much. bumping carts into seats more times than i care to remember

Everything was fine except the entertainment was not working for half of the flight.

Everything you need to know for your flight from Des Moines to Gainesville

Information on your arrival and departure airports

Des Moines (DSM)
Gainesville (GNV)

Not what you’re looking for? Find thousands of other hotels, flights, car rentals and package deals with KAYAK.