$198 Find Cheap Flights from Des Moines to South Carolina - Compare and Save

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Cheap Flights from Des Moines to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Charleston
Charleston1 stop$276
Myrtle Beach
Myrtle Beach1 stop$363
Greenville
Greenville1 stop$389
Columbia
Columbia1 stop$339
Charlotte
Charlotte1 stop$343
Charleston
Charleston1 stop$276
Myrtle Beach
Myrtle Beach1 stop$363
Greenville
Greenville1 stop$389
Columbia
Columbia1 stop$339
Charlotte
Charlotte1 stop$343

KAYAK's insights & trends for Des Moines to South Carolina flights

Get data-powered insights and trends into flights from Des Moines to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to South Carolina?

Flight prices are below average for this route right now.

Flights to South Carolina from Des Moines usually cost between $370 and $596 in January.
The lowest price found in the past 5 days was $276 on Multiple Airlines (Jan 11-Jan 19).

What is the cheapest month to fly from Des Moines to South Carolina?

The cheapest month for flights from Des Moines to South Carolina is January, when tickets cost $386 (return) on average. On the other hand, the most expensive months are March and December, when the average cost of round-trip tickets is $502 and $491 respectively.

Good to know

Low season

August

Cheapest flight

$198
Best time to beat the crowds but there is an average 12% increase in price.
Most popular time to fly with an average 6% increase in price.
Flight from Des Moines to Greenville

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Des Moines to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Des Moines to the following destinations at these prices or less: Charlotte $211 one-way - $437 round-trip

Reviews of the top 4 airlines serving from Des Moines to South Carolina

 
Need help choosing which airline to fly with from Des Moines to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4213 reviews
8.1Boarding
7.4Entertainment
8.0Comfort
8.6Crew
7.0Food
Airline reviews

I fly out every other weekend and this is the 4th time my flight has been delayed at Southwest. I will be flying out twice a month on average for the next 6-7 months. If this is your average ‘on time’ I’ll probably be flying another airline.

8.0 ExcellentDelores, Oct 2026
Read more Southwest reviews

I fly out every other weekend and this is the 4th time my flight has been delayed at Southwest. I will be flying out twice a month on average for the next 6-7 months. If this is your average ‘on time’ I’ll probably be flying another airline.

WiFi was inoperable - second in four recent Southwest flights where that was true. I need WiFi for work and if Southwest cannot provide, I’ll stop using it

It’s too cold like fridge and they don’t offer a blanket with expensive price

Boarding now takes twice as long since going with assigned seats.

Smooth flights, connection, and friendly crew in the air and at the gate.

Flight was delayed again. I fly out every other weekend and lately the flight is delayed 3 out of five times 🤷🏻‍♀️

A List preferred boarding was nice Asked for a mask and cheerfully received Denver bag check-in is tricky. Not near other checking desk. Have to navigate to east security and up to level six for bag checkin. TSA busy and 20 minutes process thru pre lines Denver train to gates quick but one more thing to plan time for and long concourse walk to gate

Nice managed … it was a smaller plane, so the seating wasn’t as comfortable.

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Very good- all went as planned. Flight was on time. Seating was a little sub , as always. Snacks and entertainment were basic. We arrived on time- no problems.

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

All good on Delta's part. Passengers could be a little more courteous to each other.

The pilots were good. Disappointing when planes don't have electrical ports

No complaints - left 20 minutes later than planned but still arrived on time.

Takeoff delayed 2 hrs. Boarded on time to find we were missing part of the flight crew. Then informed that they had loaded too much fuel. Spent 1 1/2 hrs sitting there burning off the excess, which included a couple of laps around the runway until we were light enough to fly! Ridiculous!

The WiFi went out an hour before the flight was due to land so I did not get my money's worth.

I have been flying united for a long time but now I’m done

It's not United, but TSA security at Terminal A in Newark is a disaster and seriously makes me consider switching to flying out of JFK. The touchless TSA pre-check had a line of over 50 people and the bag screening was so slow that it limited the flow of people through the facial recognition process. It is the only airport that I frequent that has this issue and makes me reconsider whether I should fly out of Newark given the wasted time and frustration it causes. As I said, it is not a United issue but will impact United if people choose to stop utilizing Newark airport because of the poor experience.

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

Awful. No counter attendants. No dinner offered due to delays.

Very rough getting into denver. my kid threw up it was so rough.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.

First class snacks - stewardess gave out multiples to everyone until there was almost no selection left when she got back to me last in first class cabin. Nothing left that I would eat.

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

For the price of the ticket you get nothing. The plane had 1 bathroom in the back and when the flight attendant did service no one could use it. No announcement just was told to go back to my seat. Ridiculous and rude.

In-flight Wi-Fi didn’t work and the flight was 25 minutes late. The Embraer plane I was on was pretty old and the tray table was broken.

More options for your flight from Des Moines to South Carolina

Complete your trip to South Carolina with a hotel stay or car rental