$134 Find Cheap Flights from Des Moines to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South Carolina departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$287
Myrtle Beach
Myrtle Beach1 stop$227
Greenville
Greenville1 stop$261
Columbia
Columbia1 stop$285
Charlotte
Charlotte1 stop$314
Charleston
Charleston1 stop$287
Myrtle Beach
Myrtle Beach1 stop$227
Greenville
Greenville1 stop$261
Columbia
Columbia1 stop$285
Charlotte
Charlotte1 stop$314

Book Cheap Des Moines to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South Carolina

Sun, Oct 11 - Thu, Oct 22
Multiple Airlines Logo
3:54 pm - 7:58 am
DSM
-
MYR
15h 04m
1 stop
Multiple Airlines Logo
8:35 am - 2:42 pm
MYR
-
DSM
7h 07m
1 stop
$227Multiple Airlines
Thu, Oct 1 - Thu, Oct 8
Multiple Airlines Logo
8:10 am - 11:44 am
DSM
-
MYR
26h 34m
2 stops
Multiple Airlines Logo
8:35 am - 2:42 pm
MYR
-
DSM
7h 07m
1 stop
$236Multiple Airlines
Sat, Sep 5 - Sat, Sep 12
Delta Logo
4:11 pm - 11:54 pm
DSM
-
CAE
6h 43m
1 stop
Delta Logo
11:57 am - 3:15 pm
CAE
-
DSM
4h 18m
1 stop
$285Delta
Sat, Sep 12 - Tue, Sep 22
United Airlines Logo
8:00 am - 7:07 pm
DSM
-
CAE
10h 07m
2 stops
United Airlines Logo
6:25 am - 10:31 am
CAE
-
DSM
5h 06m
1 stop
$290United Airlines
Wed, Aug 12 - Wed, Aug 19
Delta Logo
5:40 am - 1:14 pm
DSM
-
CAE
6h 34m
1 stop
Delta Logo
5:40 am - 10:43 am
CAE
-
DSM
6h 03m
1 stop
$297Delta
Wed, Aug 12 - Tue, Aug 18
United Airlines Logo
6:00 am - 2:21 pm
DSM
-
CAE
7h 21m
2 stops
United Airlines Logo
6:25 am - 10:26 am
CAE
-
DSM
5h 01m
1 stop
$302United Airlines
Sat, Aug 22 - Sat, Aug 29
Southwest Logo
12:10 pm - 6:10 pm
DSM
-
CLT
5h 00m
1 stop
Southwest Logo
3:25 pm - 7:25 pm
CLT
-
DSM
5h 00m
1 stop
$321Southwest
Mon, Oct 5 - Thu, Oct 8
Southwest Logo
6:20 am - 8:05 pm
DSM
-
CHS
12h 45m
1 stop
Southwest Logo
7:15 pm - 10:55 pm
CHS
-
DSM
4h 40m
1 stop
$322Southwest
Fri, Jul 31 - Thu, Aug 6
American Airlines Logo
5:12 am - 1:23 pm
DSM
-
CAE
7h 11m
1 stop
American Airlines Logo
6:46 pm - 11:44 pm
CAE
-
DSM
5h 58m
1 stop
$324American Airlines
Sat, Sep 12 - Thu, Sep 17
American Airlines Logo
7:00 am - 2:55 pm
DSM
-
SAV
6h 55m
1 stop
American Airlines Logo
4:15 pm - 7:48 pm
SAV
-
DSM
4h 33m
1 stop
$336American Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to South Carolina flights

Get data-powered insights and trends into flights from Des Moines to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to South Carolina departing in October.

What is the cheapest month to fly from Des Moines to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to South Carolina is September, when tickets cost $338 (return) on average. On the other hand, the most expensive months are March and November, when the average cost of round-trip tickets is $473 and $467 respectively.

Good to know

Low season

December

Cheapest flight

$134
Best time to beat the crowds with an average 3% drop in price.
Most popular time to fly with an average 10% increase in price.
Flight from Des Moines to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Des Moines to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Des Moines to the following destinations at these prices or less: Charlotte $242 one-way - $391 round-trip

Reviews of the top 4 airlines serving from Des Moines to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4242 reviews
8.1Boarding
8.6Crew
7.5Entertainment
7.0Food
8.0Comfort
Airline reviews

Friendly crew kept coming by to make sure all was ok, provide additional refreshments, etc.

10.0 ExcellentTamara, Jul 2026
MCO - DEN
Read more Southwest reviews

Friendly crew kept coming by to make sure all was ok, provide additional refreshments, etc.

It was good. Last flight was delayed but I always say that is in God's plan

Red eye from San Diego. Temperature of the cabin was way too warm and the air duct flowed very little air.

Overall good, just screaming kids in the area the whole flight.

My experience will Southwest was good. I wish there was more entertainment and the boarding process was slow at time but other than that my experience was great definitely will be flying with SouthWest again.

Flight was delayed by 2 hours, meaning that a flight to Dwnver which should have arrived at 11pm came into the airport at 1 am. Made for a very long day.

I think Southwest is the number one airline that anyone can fly I have flown for the first time Frontier and what a joke and their customer service United was a very strange experience I'm only sticking to Southwest from here on out for sure

Great job! My family doesnt fly often but we felt safe 100%

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Seat was too small for someone as tall as I am. I was behind an exit row making my leg room even less. There flights were delayed by multiple hours. Some weather related and others staff related. The plane was hot. Horrible experience.

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

All good on Delta's part. Passengers could be a little more courteous to each other.

The pilots were good. Disappointing when planes don't have electrical ports

No complaints - left 20 minutes later than planned but still arrived on time.

We flew business fares. Was amazing. However, the check in didn't offer business fares preboarding which is less hectic. 8/10 due to this. Staff compared to Canadian carriers go above and beyond. Would gladly fly United again.

It was extremely hot in the cabin the entire flight, vent air was worn

The Wi-Fi did not work, so you weren't able to watch entertainment on your own device. They did not have wired headphones so you couldn't watch it on the in-seat entertainment screen either. There was plenty of time to do a drink and snag service but the flight attendants chose not to.

Great experience, boarding was fast and efficient, so much so that we arrived to Chicago very early

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

Awful. No counter attendants. No dinner offered due to delays.

Very rough getting into denver. my kid threw up it was so rough.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

For the price of the ticket you get nothing. The plane had 1 bathroom in the back and when the flight attendant did service no one could use it. No announcement just was told to go back to my seat. Ridiculous and rude.

In-flight Wi-Fi didn’t work and the flight was 25 minutes late. The Embraer plane I was on was pretty old and the tray table was broken.

American Airlines no longer has Bischoff biscuits. This is intolerable.

Everything you need to know for your flight from Des Moines to South Carolina

Information on your arrival and departure airports