$123 Find Cheap Flights from Des Moines to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South Carolina departing on 9/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$327
Myrtle Beach
Myrtle Beach2 stops$284
Greenville
Greenville1 stop$365
Columbia
Columbia1 stop$295
Charlotte
Charlotte1 stop$256
Charleston
Charleston1 stop$327
Myrtle Beach
Myrtle Beach2 stops$284
Greenville
Greenville1 stop$365
Columbia
Columbia1 stop$295
Charlotte
Charlotte1 stop$256

Book Cheap Des Moines to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South Carolina

Thu, Sep 10 - Thu, Sep 17
Frontier Logo
11:29 am - 6:59 pmDSM  Des Moines-CLT Charlotte Douglas
6h 30m1 stop Denver Intl
Frontier Logo
7:54 pm - 7:33 pmCLT  Charlotte Douglas-DSM Des Moines
24h 39m1 stop Denver Intl
$256Frontier
Thu, Sep 24 - Thu, Oct 1
Frontier Logo
11:29 am - 6:59 pmDSM  Des Moines-CLT Charlotte Douglas
6h 30m1 stop Denver Intl
Frontier Logo
7:54 pm - 7:33 pmCLT  Charlotte Douglas-DSM Des Moines
24h 39m1 stop Denver Intl
$256Frontier
Sat, Sep 5 - Sat, Sep 12
United Airlines Logo
3:20 pm - 9:28 pmDSM  Des Moines-CAE Columbia Metropolitan
5h 08m1 stop Chicago O'Hare Intl
United Airlines Logo
5:38 pm - 10:55 pmCAE  Columbia Metropolitan-DSM Des Moines
6h 17m1 stop Chicago O'Hare Intl
$295United Airlines
Sat, Sep 5 - Sat, Sep 12
United Airlines Logo
6:00 am - 2:21 pmDSM  Des Moines-CAE Columbia Metropolitan
7h 21m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
5:38 pm - 10:55 pmCAE  Columbia Metropolitan-DSM Des Moines
6h 17m1 stop Chicago O'Hare Intl
$300United Airlines
Wed, Nov 18 - Mon, Nov 23
Delta Logo
6:50 pm - 11:53 pmDSM  Des Moines-CAE Columbia Metropolitan
4h 03m1 stop Atlanta Hartsfield-Jackson
Delta Logo
1:59 pm - 6:05 pmCAE  Columbia Metropolitan-DSM Des Moines
5h 06m1 stop Atlanta Hartsfield-Jackson
$307Delta
Wed, Dec 16 - Fri, Jan 1
Delta Logo
11:28 am - 5:10 pmDSM  Des Moines-CAE Columbia Metropolitan
4h 42m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:35 am - 10:18 amCAE  Columbia Metropolitan-DSM Des Moines
5h 43m1 stop Atlanta Hartsfield-Jackson
$307Delta
Tue, Aug 25 - Tue, Sep 8
American Airlines Logo
2:21 pm - 10:52 pmDSM  Des Moines-CAE Columbia Metropolitan
7h 31m1 stop Washington, D.C. Reagan-National
American Airlines Logo
6:46 pm - 11:44 pmCAE  Columbia Metropolitan-DSM Des Moines
5h 58m1 stop Washington, D.C. Reagan-National
$322American Airlines
Sat, Sep 5 - Fri, Sep 11
American Airlines Logo
1:43 pm - 9:26 pmDSM  Des Moines-MYR Myrtle Beach Intl
6h 43m1 stop Charlotte Douglas
American Airlines Logo
8:08 am - 12:04 pmMYR  Myrtle Beach Intl-DSM Des Moines
4h 56m1 stop Charlotte Douglas
$325American Airlines
Mon, Aug 31 - Sat, Sep 5
Southwest Logo
5:40 am - 11:10 amDSM  Des Moines-CLT Charlotte Douglas
4h 30m1 stop Chicago Midway
Southwest Logo
7:55 am - 11:30 amCLT  Charlotte Douglas-DSM Des Moines
4h 35m1 stop Chicago Midway
$343Southwest
Fri, Oct 30 - Tue, Nov 3
Southwest Logo
6:20 am - 6:40 pmDSM  Des Moines-CHS Charleston
11h 20m2 stops Denver Intl Dallas Love Field
Southwest Logo
8:00 am - 11:25 amCHS  Charleston-DSM Des Moines
4h 25m1 stop Chicago Midway
$350Southwest
Booking Insights

KAYAK's insights & trends for Des Moines to South Carolina flights

Get data-powered insights and trends into flights from Des Moines to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to South Carolina departing in September.

Flight prices are below average for this route right now.

Flights to South Carolina from Des Moines usually cost between $387 and $438 in September.
The lowest price found in the past 5 days was $327 on American Airlines (Sep 20-Sep 29).

What is the cheapest month to fly from Des Moines to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to South Carolina is September, when tickets cost $357 (return) on average. On the other hand, the most expensive months are March and November, when the average cost of round-trip tickets is $473 and $450 respectively.

Good to know

Low season

February

Cheapest flight

$123
Best time to beat the crowds but there is an average 5% increase in price.
Most popular time to fly with an average 2% increase in price.
Flight from Des Moines to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Des Moines to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Des Moines to the following destinations at these prices or less: Charlotte $268 one-way - $395 round-trip

Reviews of the top 4 airlines serving from Des Moines to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4216 reviews
7.5Entertainment
8.1Boarding
7.0Food
8.6Crew
8.0Comfort
Airline reviews

Fairly good - the seats seemed more comfortable on this flight. The staff out of Detroit were quite friendly. But they directed us to the wrong carousel for luggage. :(

8.0 ExcellentDavid, Aug 2026
Read more Southwest reviews

Fairly good - the seats seemed more comfortable on this flight. The staff out of Detroit were quite friendly. But they directed us to the wrong carousel for luggage. :(

Just crazy with times being pushed and pushed and pushed and gate crew at Philly super rude and unprofessional with many under stress with delays.

I liked the new boarding process. I thought the buyup options (legroom, early boarding) to be easy to request and reasonably priced. All the Southwest team from gate to in-flight were so nice.

Flight time kept changing and so did the gate. It was very frustrating

Exceptional. The gate crew responded quickly and got me onto this earlier flight as the final passenger, saving me more than four hours of wait time for my reserved flight.

The flight was delayed due to earlier issues at other airports. The crew was excellent & made it a good trip.

Boarding process of asking for volunteers to check bags goes against the system you had before with 2 bags checked free. This process is more of a guilt trip than a caring attitude toward the customer. In addition bag-size scrutiny has increased which also slows down the process of boarding. My wife said she will not fly on your airline again unless there is no other option.

Eveeyrime I fly they are begging for bags due to cabin overhead space. What they should so ia take the bags that are clearly too big to fit wheels first on their side. And those of us who give up the bag should really get their bags first. When boarding, nobody wants stupid jokes about how hot it is on board. Give us some cool air. Im usually sick from the heat by the time we take off.

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Some of the passengers are coming on board with luggage so overstuffed and/or too large that have no business going into the overhead bins.

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

All good on Delta's part. Passengers could be a little more courteous to each other.

The pilots were good. Disappointing when planes don't have electrical ports

No complaints - left 20 minutes later than planned but still arrived on time.

Really old place. Not as clean as it should be, tray tables needed better cleaning. The items, trays and some other items need to b6 engineered. Anything task you or crew may do is incredibly load, seriously engineer for quiet smooth, easy. Just opening and closing the tray table is actually dangerous and can easily injure a finger. I'm sure it happens as it happened to me! First time I used United and likely will be the last!

Like the fact that the boarding was expedited. But the delay and chaos around the onboarding was not appreciated.

Flight was 2.5 late. Maybe not United’s fault but late none the less. We were late as well on the first leg. WiFi quit working with an hour left.

Old 757 with poor entertainment system. United no longer partners with United for free text and email. O'Hara an absolute disaster! Limited gates clauses two hour delay. Unfortunately this appears to be the norm.

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

Awful. No counter attendants. No dinner offered due to delays.

Very rough getting into denver. my kid threw up it was so rough.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

For the price of the ticket you get nothing. The plane had 1 bathroom in the back and when the flight attendant did service no one could use it. No announcement just was told to go back to my seat. Ridiculous and rude.

In-flight Wi-Fi didn’t work and the flight was 25 minutes late. The Embraer plane I was on was pretty old and the tray table was broken.

American Airlines no longer has Bischoff biscuits. This is intolerable.

Everything you need to know for your flight from Des Moines to South Carolina

Information on your arrival and departure airports