$127 Find Cheap Flights from Des Moines to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to South Carolina departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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1 adult, Economy, 0 bags

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Cheap Flights from Des Moines to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$263
Myrtle Beach
Myrtle Beach2 stops$257
Greenville
Greenville1 stop$263
Columbia
Columbia1 stop$285
Charlotte
Charlotte1 stop$267
Charleston
Charleston1 stop$263
Myrtle Beach
Myrtle Beach2 stops$257
Greenville
Greenville1 stop$263
Columbia
Columbia1 stop$285
Charlotte
Charlotte1 stop$267

Book Cheap Des Moines to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to South Carolina

Thu, Sep 10 - Sun, Sep 13
Multiple Airlines Logo
1:58 pm - 11:44 am
DSM
-
MYR
20h 46m
2 stops
Multiple Airlines Logo
8:27 am - 7:57 pm
MYR
-
DSM
12h 30m
1 stop
$257Multiple Airlines
Fri, Aug 7 - Fri, Aug 14
Delta Logo
6:35 pm - 11:59 pm
DSM
-
CHS
4h 24m
1 stop
Delta Logo
3:14 pm - 8:59 pm
CHS
-
DSM
6h 45m
1 stop
$263Delta
Thu, Aug 13 - Mon, Aug 17
American Airlines Logo
1:08 pm - 8:59 pm
DSM
-
MYR
6h 51m
1 stop
American Airlines Logo
6:04 pm - 11:44 pm
MYR
-
DSM
6h 40m
1 stop
$263American Airlines
Tue, Aug 4 - Sat, Aug 15
Delta Logo
2:54 pm - 8:32 pm
DSM
-
GSP
4h 38m
1 stop
Delta Logo
7:28 am - 10:43 am
GSP
-
DSM
4h 15m
1 stop
$263Delta
Thu, Aug 20 - Thu, Aug 27
Southwest Logo
3:50 pm - 9:25 pm
DSM
-
CHS
4h 35m
1 stop
Southwest Logo
7:00 am - 11:25 am
CHS
-
DSM
5h 25m
1 stop
$264Southwest
Tue, Aug 18 - Tue, Aug 25
Southwest Logo
2:40 pm - 9:10 pm
DSM
-
CLT
5h 30m
1 stop
Southwest Logo
6:35 pm - 9:55 pm
CLT
-
DSM
4h 20m
1 stop
$267Southwest
Fri, Aug 21 - Fri, Aug 28
United Airlines Logo
1:35 pm - 9:35 pm
DSM
-
CHS
7h 00m
1 stop
United Airlines Logo
10:14 am - 5:28 pm
CHS
-
DSM
8h 14m
2 stops
$268United Airlines
Sat, Nov 7 - Tue, Nov 10
American Airlines Logo
11:30 am - 6:30 pm
DSM
-
CHS
6h 00m
1 stop
American Airlines Logo
7:53 pm - 12:21 am
CHS
-
DSM
5h 28m
1 stop
$280American Airlines
Wed, Sep 9 - Wed, Sep 16
United Airlines Logo
8:00 am - 7:07 pm
DSM
-
CAE
10h 07m
2 stops
United Airlines Logo
6:25 am - 10:31 am
CAE
-
DSM
5h 06m
1 stop
$290United Airlines
Thu, Jul 30 - Thu, Aug 6
Allegiant Air Logo
9:23 am - 7:30 am
DSM
-
GSP
21h 07m
1 stop
Allegiant Air Logo
3:30 pm - 11:14 pm
GSP
-
DSM
32h 44m
2 stops
$322Allegiant Air
Booking Insights

KAYAK's insights & trends for Des Moines to South Carolina flights

Get data-powered insights and trends into flights from Des Moines to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to South Carolina departing in August.

What is the cheapest month to fly from Des Moines to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to South Carolina is September, when tickets cost $158 (return) on average. On the other hand, the most expensive months are July and May, when the average cost of round-trip tickets is $361 and $356 respectively.

Good to know

Low seasonDecember
Cheapest flight$127
Most popular time to fly and prices are also 27% lower on average.
Flight from Des Moines to Myrtle Beach

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Des Moines to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Des Moines to the following destinations at these prices or less: Charlotte $247 one-way - $392 round-trip

Reviews of the top 4 airlines serving from Des Moines to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4248 reviews
8.6Crew
7.5Entertainment
8.1Boarding
7.0Food
8.0Comfort
Airline reviews

Overall good, just screaming kids in the area the whole flight.

8.0 ExcellentAnonymous, Jul 2026
MDW - MHT
Read more Southwest reviews

Overall good, just screaming kids in the area the whole flight.

My experience will Southwest was good. I wish there was more entertainment and the boarding process was slow at time but other than that my experience was great definitely will be flying with SouthWest again.

Flight was delayed by 2 hours, meaning that a flight to Dwnver which should have arrived at 11pm came into the airport at 1 am. Made for a very long day.

I think Southwest is the number one airline that anyone can fly I have flown for the first time Frontier and what a joke and their customer service United was a very strange experience I'm only sticking to Southwest from here on out for sure

Great job! My family doesnt fly often but we felt safe 100%

Great job Southwest! My family doesn't fly often but we felt safe the whole time.

SW can't get their wifi right. I upgrade to insure wifi service but the last two trips had intermittent service. Not worth the extra costs.

The flight was late. The crew was rude. There was no food. Cramped and uncomfortable. Nothing about this flight was good.

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

The team was wonderful. The entertainment screens were not working, so they recommended that we use the plane wifi to watch entertainment on our phones and none of the Delta entertainment links worked. Extremely frustrating process.

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

All good on Delta's part. Passengers could be a little more courteous to each other.

The pilots were good. Disappointing when planes don't have electrical ports

No complaints - left 20 minutes later than planned but still arrived on time.

Boarded from a very small gate at LAX. Staff at gate had us line up, then waited 25 minutes to board without a word of explanation. Plane arrived on time then waited 20 minutes for a plane to vacate our gate. Majority of bags arrived after 15 minutes but it took an hour for a small number of remaining bags to be off-loaded despite my “priority” bag tag.

It's fine but Newark to Nashville was too long

The flight was delayed because they closed several flight ways because of air shows, fire works, etc.

Horrible experience. They delayed our flight 7 hours!! We had to seat at the airport with kids on 4th July all day!

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

Awful. No counter attendants. No dinner offered due to delays.

Very rough getting into denver. my kid threw up it was so rough.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

Multiple gate changes and significant delay leaving DFW. Made for a late arrival

For the price of the ticket you get nothing. The plane had 1 bathroom in the back and when the flight attendant did service no one could use it. No announcement just was told to go back to my seat. Ridiculous and rude.

In-flight Wi-Fi didn’t work and the flight was 25 minutes late. The Embraer plane I was on was pretty old and the tray table was broken.

American Airlines no longer has Bischoff biscuits. This is intolerable.

Everything you need to know for your flight from Des Moines to South Carolina

Information on your arrival and departure airports