$131 Find Cheap Flights from Des Moines to Knoxville - Compare and Save

In the last 5 days, the lowest price for a flight from Des Moines to Knoxville was $131 for a one-way ticket and $190 for a round-trip.

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On your way to Knoxville, you’ll fly out from Des Moines. You’ll be landing at Knoxville McGhee Tyson.

We unfortunately don’t have that data for this specific route.

SkyTeam, Star Alliance, and oneworld are the airline alliances operating flights between Des Moines and Knoxville, with SkyTeam being the most commonly used for this route.

The two airlines most popular with KAYAK users for flights from Des Moines to Knoxville are Delta and United Airlines. With an average price for the route of $386 and an overall rating of 7.8, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $387 and an overall rating of 7.4.

KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Knoxville.

KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and TYS can sometimes prove cheaper using this method.

Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.