DSM - TYS

$82 Find Cheap Flights from Des Moines to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 7/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$213
Typical prices: $447-$308
Allegiant Air
Thu 7/16Sun 7/19
DSM - TYS • 1 stop
Cheapest one-way
$82
Typical prices: $154-$188
Allegiant Air
Thu 7/16
DSM - TYS • 1 stop
Top airlines
Cheapest • from $213 (round-trip)
Best reviews • 7.8 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $203 (round-trip)
Shortest trip • 4h 23m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 100% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Des Moines to Knoxville (DSM-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Knoxville

Thu, Jul 16 - Sun, Jul 19
Allegiant Air Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Allegiant Air Logo
3:38 pm - 10:47 pm
TYS
-
DSM
8h 09m
1 stop
$213Allegiant Air
Thu, Jul 16 - Mon, Jul 20
Allegiant Air Logo
5:08 pm - 10:00 pm
DSM
-
TYS
27h 52m
1 stop
Allegiant Air Logo
10:05 pm - 3:24 pm
TYS
-
DSM
18h 19m
1 stop
$243Allegiant Air
Tue, Aug 4 - Tue, Aug 11
American Airlines Logo
4:48 pm - 11:51 pm
DSM
-
TYS
6h 03m
1 stop
American Airlines Logo
7:31 pm - 11:44 pm
TYS
-
DSM
5h 13m
1 stop
$279American Airlines
Wed, Aug 19 - Tue, Aug 25
United Airlines Logo
6:00 am - 2:37 pm
DSM
-
TYS
7h 37m
2 stops
United Airlines Logo
4:50 pm - 11:44 pm
TYS
-
DSM
7h 54m
1 stop
$284United Airlines
Wed, Aug 19 - Tue, Aug 25
Southwest Logo
6:10 am - 2:20 pm
DSM
-
TYS
7h 10m
2 stops
Southwest Logo
12:45 pm - 9:55 pm
TYS
-
DSM
10h 10m
2 stops
$289Southwest
Tue, Aug 4 - Tue, Aug 11
United Airlines Logo
6:00 am - 2:27 pm
DSM
-
TYS
7h 27m
2 stops
United Airlines Logo
9:00 am - 4:19 pm
TYS
-
DSM
8h 19m
1 stop
$299United Airlines
Tue, Aug 4 - Tue, Aug 11
Southwest Logo
6:10 am - 2:20 pm
DSM
-
TYS
7h 10m
2 stops
Southwest Logo
12:45 pm - 9:55 pm
TYS
-
DSM
10h 10m
2 stops
$309Southwest
Thu, Jul 16 - Tue, Jul 21
Delta Logo
11:30 am - 6:44 pm
DSM
-
TYS
6h 14m
1 stop
Delta Logo
6:05 pm - 10:29 pm
TYS
-
DSM
5h 24m
1 stop
$318Delta
Thu, Oct 29 - Sat, Oct 31
Delta Logo
3:30 pm - 11:02 pm
DSM
-
TYS
6h 32m
1 stop
Delta Logo
5:30 am - 10:18 am
TYS
-
DSM
5h 48m
1 stop
$319Delta
Tue, Aug 25 - Sun, Aug 30
United Airlines Logo
11:32 am - 4:58 pm
DSM
-
TYS
4h 26m
1 stop
United Airlines Logo
5:45 am - 2:16 pm
TYS
-
DSM
9h 31m
2 stops
$323United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Knoxville flights

Get data-powered insights and trends into flights from Des Moines to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Des Moines to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to Knoxville departing in July.

What is the cheapest month to fly from Des Moines to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Knoxville is January, where tickets cost $0 (return) on average. On the other hand, the most expensive months are September and October, where the average cost of round-trip tickets is $541 and $494 respectively.

Good to know

Low seasonNovember
Cheapest flight$82
Best time to beat the crowds with an average 49% drop in price.
Most popular time to fly and prices are also 10% lower on average.
Flight from Des Moines to Knoxville

When to book flights from Des Moines to Knoxville

Are your dates flexible? Find out the best times to travel from Des Moines to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Knoxville

  • What is the cheapest flight from Des Moines to Knoxville?

    In the last 5 days, the lowest price for a flight from Des Moines to Knoxville was $82 for a one-way ticket and $213 for a round-trip.

  • Do I need a passport to fly between Des Moines and Knoxville?

    No

  • Which airports will I be using when flying from Des Moines to Knoxville?

    On your way to Knoxville, you’ll fly out from Des Moines. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Des Moines to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Knoxville?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between Des Moines and Knoxville, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Knoxville, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to Knoxville are Delta and United Airlines. With an average price for the route of $356 and an overall rating of 7.8, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $387 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Des Moines to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Des Moines to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8417 reviews
8.1Boarding
8.5Crew
7.2Food
7.8Comfort
7.8Entertainment
Airline reviews

Great experience nice pilot very soft and easy landing and take off

10.0 ExcellentKaran, Jun 2026
LGA - ATL
Read more Delta reviews

Great experience nice pilot very soft and easy landing and take off

We sat on the runway for over an hour before departure. That was unwelcome.

Horrible. Faucet in sink not working, wifi not working. Didn’t bring food or snacks

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

From checking to boarding, it was a seamless experience. The service agents were so helpful. The flight crew was so pleasant.

Gate agent showed up 20 minutes before boarding and was not at all friendly. Had to take this flight due to the one on the day before being cancelled and any later options were already full with long standby lists. Despite having paid for Delta Comfort seats, Delta did not allow me (or anyone) to choose their seat. The agent assigned them for everyone just prior to boarding. Self seat selection was allowed on the original flight. Flight staff was great - very friendly.

Flight attendants were great. Cheerful, upbeat and friendly. Jet, in particular, was fantastic.

I have Precheck. Flew HPN to DEN and return this past weekend. Delta didn't attach my Precheck number to this trip. So it was waiting in general line especially in Denver. Unavailable.

Original flight was delayed, then cancelled and the gate staff did not expedite rebooking. Also, no instructions were given that a ticket number was needed before being called to facilitate rebooking. This could have been much more organized.

Be on time? When not on time a circling for over an hour offer more than 1 bag of chips to the passengers? It was a 7 hour flight by the time we got done.

They delayed the flight 3 hours because it wasn't full they moved us to 5 different gates probably the worst airline ever not even spirit is this bad.

Very easy ! Use the kiosk and bag drop and right to security within 10 min

Checking bag at terminal was horrible. No agents to check us in and only 1 kiosk working. Boarding went ok. Crew onboard was very scattered rained. Missed our row while serving and then didn’t see them hardly again.

Crew was amazing, takeoff wonderful. The bathroom was disgusting from before takeoff the odor made the flight uncomfortable as you could smell the bathroom from the center of the plane where we were sitting. Smelled like raw sewage. My daughter was throwing up as we landed due to the smell and horrible turbulence as we approached Newark.

Airline tickets are not cheap. You expect reliable competent service. Thanks to canceled flights and botched transfers we arrived at our destination two days late. This is not acceptable

Horrible! Several delays and then was cancelled! I spent over 24 hours in the airport and was unable to get a hotel or food voucher.

The entertainment is a bit limited, it would be better if they added some games to play besides the movies and tv shows. But the seats are comfortable and the crew is polite

This planes staff was top tier. Everything went great and had a great flight home.

Food was great. Staff was phenomenal. Seats were a bit hard and could use a lot more entertainment options as far as movies to choose from. WiFi was good. Overall great trip.

This was an overnight flight, and in the morning they did know coffee service. How you can throw passengers in a San Francisco airport at 5:40 a.m. in the morning and not giving them Coffee is a crime.

Plane temperature was so hot that everyone on the plane was sweating. Departure gates changed 3 times in the hour before the flight. Internet service was so poor in the terminal that updates weren't always being received.

We had a mechanical delay which made us 90 minutes late (9:30 PM) then land and put into the penalty box because a plane was in our gate? What the hell! We should get priority.Damn American.

Check in for 5am flight at RDU was hampered by American check in counters being seriously understaffed , was told even supervisor called out. Took so long in line for special services check in that we missed our 5am departure even after arriving at 3:30am. Had to be rescheduled to later flight from Charlotte to St Thomas.

Delayed flight due to maintenance and I have had multiple delayed flights due to maintenance in the last month plus

Excellent service. Flight attendance like Jessica,, on our flight, is a reason I wouldn’t mind flying through British Airways again. Jessica,, was very courteous and helpful.

The seats were extremely cramped, with very little legroom or personal space. There was no room left in the overhead bins for a backpack, and the space under the seat in front was so limited that I could barely fit my bag underneath. Overall, the seating arrangement felt very uncomfortable and overcrowded.

Significant delays on my trip to Chicago and my trip back to NY

Terrible boarding and first class experience. Nice staff but overall disorganized, dirty plane.

Delayed by 5 hours and I had to wit in the airport for more than 6+ hours.

weather delay of almost 2 hours then we landed and our gate wasn't available so we waited another 30 min

Everything you need to know for your flight from Des Moines to Knoxville

Information on your arrival and departure airports