Find Cheap Flights from Des Moines to Knoxville McGhee Tyson (DSM - TYS)

Depart
Return
1 adult
Adults
18-64
Seniors
65+
Youths
12-17
Children
2-11
Seat Infants
under 2
Lap Infants
under 2
The price shown for each flight will be the average for all passengers including any infants.
Compare vs. KAYAK all | none
Browse Origins:
Browse Destinations:

Dates flexible? Here are the best fares found in the past 48 hours...

Book cheap flights from Des Moines to Knoxville McGhee Tyson

(Round-trip)
Depart: Tue Aug 8 2017 Return: Sun Aug 13 2017 Trip spans 6 days
United
United
DSM
12:00a
TYS
4:10a
4h 10m
1 stop
TYS
12:00a
DSM
3:59a
3h 59m
1 stop
Depart: Tue Aug 8 2017 Return: Mon Aug 14 2017 Trip spans 7 days
Major Airline
Major Airline
DSM
12:00a
TYS
11:53p
23h 53m
2 stops
TYS
12:00a
DSM
3:52a
27h 52m
2 stops
Depart: Wed Sep 27 2017 Return: Sun Oct 1 2017 Trip spans 5 days
Delta
Delta
DSM
12:00a
TYS
6:03a
6h 03m
1 stop
TYS
12:00a
DSM
4:46a
4h 46m
1 stop
Depart: Wed Sep 27 2017 Return: Sat Sep 30 2017 Trip spans 4 days
American Airlines
American Airlines
DSM
12:00a
TYS
6:43a
6h 43m
1 stop
TYS
12:00a
DSM
4:28a
4h 28m
1 stop
Depart: Tue Aug 8 2017 Return: Sat Aug 12 2017 Trip spans 5 days
Frontier
Frontier
DSM
12:00a
TYS
11:53p
23h 53m
1 stop
TYS
12:00a
DSM
10:37p
22h 37m
1 stop
Depart: Wed Aug 9 2017 Return: Sun Aug 13 2017 Trip spans 5 days
United
United
DSM
12:00a
TYS
4:10a
4h 10m
1 stop
TYS
12:00a
DSM
3:59a
3h 59m
1 stop
Depart: Thu Sep 14 2017 Return: Sun Sep 17 2017 Trip spans 4 days
Major Airline
Major Airline
DSM
12:00a
TYS
12:18a
0h 18m
1 stop
TYS
12:00a
DSM
2:18a
2h 18m
1 stop
Depart: Wed Sep 27 2017 Return: Sat Sep 30 2017 Trip spans 4 days
Delta
Delta
DSM
12:00a
TYS
4:19a
4h 19m
1 stop
TYS
12:00a
DSM
6:12a
6h 12m
1 stop
Depart: Fri Oct 20 2017 Return: Sun Oct 22 2017 Trip spans 3 days
American Airlines
American Airlines
DSM
12:00a
TYS
5:15a
5h 15m
1 stop
TYS
12:00a
DSM
8:44a
8h 44m
2 stops
Depart: Thu Aug 10 2017 Return: Sun Aug 13 2017 Trip spans 4 days
United
United
DSM
12:00a
TYS
4:29a
4h 29m
1 stop
TYS
12:00a
DSM
3:59a
3h 59m
1 stop
Depart: Sat Jul 22 2017 Return: Tue Jul 25 2017 Trip spans 4 days
American Airlines
American Airlines
DSM
12:00a
TYS
3:54a
3h 54m
1 stop
TYS
12:00a
DSM
4:26a
4h 26m
1 stop
Depart: Sat Jul 22 2017 Return: Tue Jul 25 2017 Trip spans 4 days
Delta
Delta
DSM
12:00a
TYS
4:07a
4h 07m
1 stop
TYS
12:00a
DSM
6:04a
6h 04m
1 stop
Depart: Fri Aug 18 2017 Return: Sun Aug 20 2017 Trip spans 3 days
United
United
DSM
12:00a
TYS
4:20a
4h 20m
1 stop
TYS
12:00a
DSM
5:41a
5h 41m
1 stop
Depart: Tue Aug 8 2017 Return: Sun Aug 13 2017 Trip spans 6 days
Delta
Delta
DSM
12:00a
TYS
4:33a
4h 33m
1 stop
TYS
12:00a
DSM
5:29a
5h 29m
1 stop
Depart: Tue Jul 25 2017 Return: Mon Jul 31 2017 Trip spans 7 days
American Airlines
American Airlines
DSM
12:00a
TYS
7:07a
7h 07m
1 stop
TYS
12:00a
DSM
6:06a
6h 06m
1 stop
Depart: Thu Sep 14 2017 Return: Sun Sep 17 2017 Trip spans 4 days
United
United
DSM
12:00a
TYS
4:20a
4h 20m
1 stop
TYS
12:00a
DSM
4:31a
4h 31m
1 stop
Depart: Thu Aug 10 2017 Return: Sun Aug 13 2017 Trip spans 4 days
Delta
Delta
DSM
12:00a
TYS
6:05a
6h 05m
1 stop
TYS
12:00a
DSM
5:29a
5h 29m
1 stop
Depart: Wed Jul 26 2017 Return: Mon Jul 31 2017 Trip spans 6 days
American Airlines
American Airlines
DSM
12:00a
TYS
7:07a
7h 07m
1 stop
TYS
12:00a
DSM
6:06a
6h 06m
1 stop
Depart: Fri Jul 21 2017 Return: Tue Jul 25 2017 Trip spans 5 days
United
United
DSM
12:00a
TYS
4:10a
4h 10m
1 stop
TYS
12:00a
DSM
5:36a
5h 36m
1 stop
Depart: Wed Dec 27 2017 Return: Sat Dec 30 2017 Trip spans 4 days
Major Airline
Major Airline
DSM
12:00a
TYS
12:18a
0h 18m
1 stop
TYS
12:00a
DSM
2:18a
2h 18m
1 stop
* Prices are per person and are for e–tickets and include all taxes & fees in USD.

We attempt to get accurate prices, however, prices are not guaranteed.

Here's why:

We’re not the seller.
At KAYAK we don’t set the prices, so it’s not possible for us to guarantee what other companies are selling.

We compile tonnes of data for you
Our service lets you quickly and easily compare results from hundreds of travel sites at once. In this sense, KAYAK is a search engine and we can't guarantee prices we find.

Why aren’t prices accurate 100% of the time?
Prices on airline seats, hotel rooms and car rentals can change frequently. Several people may also be trying to buy the same travel option simultaneously. As a result, you may find, on occasion, that certain prices are no longer available.

If you have more questions or if you have a bad price to report to us,
please send us an email and someone from our team will get back to you promptly.

Airports
Origin

Des Moines
$376
Destination

Knoxville
$376