DSM - TYS

$120 Find Cheap Flights from Des Moines to Knoxville - Compare and Save

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Everything you should know

Cheapest round-trip
$239
Typical prices: $299-$436
Delta
Wed 10/24Sat 10/27
DSM - TYS • 1 stop
Cheapest one-way
$120
Typical prices: $165-$318
American Airlines
Wed 10/24
DSM - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Des Moines and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
November
Cheapest • 34% price drop
July
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Detroit Metropolitan Wayne County (DTW)
Cheapest • Avg $203 (round-trip)
Minneapolis St Paul (MSP)
Shortest trip • 4h 43m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Des Moines to Knoxville (DSM-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Knoxville

Tue, Oct 27 - Wed, Oct 28
Delta Logo
3:03 pm - 10:22 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 19m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 10:42 amTYS  Knoxville McGhee Tyson-DSM Des Moines
6h 02m1 stop Atlanta Hartsfield-Jackson
$239Delta
Sat, Oct 24 - Tue, Oct 27
Delta Logo
4:01 pm - 11:02 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 01m1 stop Minneapolis St Paul
Delta Logo
10:29 am - 2:09 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 40m1 stop Atlanta Hartsfield-Jackson
$239Delta
Sat, Oct 24 - Wed, Oct 28
Delta Logo
5:39 am - 10:53 amDSM  Des Moines-TYS Knoxville McGhee Tyson
4h 14m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:23 pm - 10:33 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 10m1 stop Atlanta Hartsfield-Jackson
$239Delta
Sun, Sep 27 - Thu, Oct 1
Allegiant Air Logo
1:58 pm - 7:34 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
28h 36m1 stop Philadelphia
Allegiant Air Logo
2:06 pm - 9:31 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
8h 25m1 stop Sarasota Bradenton Intl
$264Allegiant Air
Fri, Nov 13 - Tue, Nov 17
United Airlines Logo
1:27 pm - 10:32 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
8h 05m1 stop Denver Intl
United Airlines Logo
1:56 pm - 5:28 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 32m1 stop Chicago O'Hare Intl
$271United Airlines
Fri, Nov 13 - Tue, Nov 17
Southwest Logo
6:40 am - 6:45 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
11h 05m1 stop Denver Intl
Southwest Logo
7:05 am - 2:15 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
8h 10m2 stops Nashville Intl Denver Intl
$290Southwest
Mon, Oct 26 - Fri, Oct 30
Southwest Logo
4:30 pm - 10:45 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
5h 15m2 stops Chicago Midway Nashville Intl
Southwest Logo
5:30 pm - 10:20 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 50m1 stop Denver Intl
$308Southwest
Sat, Oct 24 - Sat, Oct 31
United Airlines Logo
11:27 am - 11:59 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
11h 32m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
United Airlines Logo
1:54 pm - 5:33 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 39m1 stop Chicago O'Hare Intl
$324United Airlines
Wed, Oct 28 - Mon, Nov 2
American Airlines Logo
11:22 am - 7:32 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
7h 10m1 stop Charlotte Douglas
American Airlines Logo
8:52 pm - 12:26 amTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 34m1 stop Chicago O'Hare Intl
$335American Airlines
Tue, Oct 27 - Mon, Nov 2
American Airlines Logo
9:26 am - 4:02 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
5h 36m1 stop Chicago O'Hare Intl
American Airlines Logo
8:52 pm - 12:26 amTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 34m1 stop Chicago O'Hare Intl
$335American Airlines
Booking Insights

Price, demand and travel trends for Des Moines to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Des Moines to Knoxville with more confidence.

How much is a round-trip flight from Des Moines to Knoxville?

Round-trip flights from Des Moines to Knoxville start at $239. Prices are below average for this route right now, with typical round-trip fares ranging from $299 to $436. The lowest price found in the past 5 days was $239 on Delta.

What's the cheapest day of the week to fly from Des Moines to Knoxville?

Monday is the cheapest day of the week to fly from Des Moines to Knoxville, it is 20% cheaper than the average day. Wednesday is the most expensive day with flight prices 33% higher than average. Based on deals found by KAYAK users in the last 12 months.

Find deals

Key details for Des Moines to Knoxville flights

Low season

January

Cheapest flight

$120
Most popular time to fly with an average 7% increase in price.
Flight from Des Moines to Knoxville

When to book flights from Des Moines to Knoxville

Are your dates flexible? Find out the best times to travel from Des Moines to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Des Moines to Knoxville flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Des Moines to Knoxville?

    Flights from Des Moines to Knoxville usually depart from Des Moines (DSM) and arrive at Knoxville McGhee Tyson (TYS).

  • What cabin classes can I book on flights from Des Moines to Knoxville?

    Only Economy Class is available on flights from Des Moines to Knoxville.

  • Which airports do connecting flights from Des Moines to Knoxville pass through?

    One-stop flights from Des Moines to Knoxville most commonly connect through:

    • Chicago O'Hare Intl (ORD) - 52% of one-stop connections
    • Charlotte Douglas (CLT) - 20% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 13% of one-stop connections
    • Detroit Metropolitan Wayne County (DTW) - 5% of one-stop connections

    Chicago O'Hare Intl (ORD) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Des Moines to Knoxville?

    Yes. Being flexible with your travel dates can save you up to 40% on the Des Moines to Knoxville route. Monday is the cheapest departure day at $297 round-trip on average, while Wednesday is the most expensive at $494, a difference of $197. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How long is a flight from Des Moines to Knoxville?

    A nonstop flight from Des Moines to Knoxville takes 0h 00m, covering 654 miles.

  • Do I need a passport to fly from Des Moines to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • How are flight prices from Des Moines to Knoxville looking right now?

    One-way fares from Des Moines to Knoxville are currently in line with typical prices for this route. Average one-way fares are about $214.

  • How much time can I save by choosing a different layover airport from Des Moines to Knoxville?

    Flying via Detroit Metropolitan Wayne County (DTW) gives the shortest average 1-stop total travel time at 4h 26m, compared with 4h 43m via Minneapolis St Paul (MSP) and 4h 53m via Chicago O'Hare Intl (ORD).

  • What is the time difference between Des Moines and Knoxville?

    Knoxville is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
    • Budget
    • Alamo
    • Thrifty
    • Enterprise Rent-A-Car
    • Payless

  • How much should I expect to pay for a Des Moines to Knoxville flight?

    Round-trip flights from Des Moines to Knoxville range from $299 to $436, with an average of $370 over the past 12 months. Anything below $299 counts as a good deal.

Your guide to booking Des Moines to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Monday departure instead of Wednesday. On this route, Monday flights average $297 - about $197 less than Wednesday (40% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Des Moines to Knoxville trip for November. Fares historically average $246 round-trip in that month - typically $399 less than the most expensive month, which is September (based on the last 12 months).

More options for your flight from Des Moines to Knoxville

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