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DSM - TYS

$216 Find cheap flights from Des Moines to Knoxville

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Knoxville departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
Sat 6/8
Sat 6/15

Search hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Knoxville, as well as popular online travel agencies
In the last 7 days travelers have searched 43,895,468 times on KAYAK, and here is why:

Save 21% or moreCompare multiple travel sites with one search.

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Cheap flight deals from Des Moines to Knoxville (DSM-TYS)

Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices and deals for you by selecting your travel dates.
Choose your dates
7:06 am - 2:28 pmDSM-TYS
6h 22m1 stop
7:41 am - 2:13 pmTYS-DSM
7h 32m1 stop
$216American Airlines
Find Deal
Sat, Aug 31 - Fri, Sep 6
5:48 pm - 12:18 amDSM-TYS
5h 30m1 stop
6:31 pm - 11:02 pmTYS-DSM
5h 31m1 stop
$253American Airlines
Find Deal
Tue, May 28 - Tue, Jun 4
4:02 pm - 11:58 pmDSM-TYS
6h 56m1 stop
7:40 pm - 12:05 amTYS-DSM
5h 25m1 stop
$255American Airlines
Find Deal
Wed, Jun 26 - Sun, Jun 30
3:19 pm - 10:40 pmDSM-TYS
6h 21m1 stop
7:00 am - 10:41 amTYS-DSM
4h 41m1 stop
$266United Airlines
Find Deal
Fri, Sep 20 - Sun, Sep 22
4:02 pm - 11:58 pmDSM-TYS
6h 56m1 stop
7:40 pm - 12:05 amTYS-DSM
5h 25m1 stop
$275American Airlines
Find Deal
Fri, Jun 28 - Sun, Jun 30
5:48 pm - 12:18 amDSM-TYS
5h 30m1 stop
2:43 pm - 10:04 pmTYS-DSM
8h 21m2 stops
$296American Airlines
Find Deal
Tue, May 28 - Tue, Jun 4
6:04 am - 11:04 amDSM-TYS
4h 00m1 stop
5:30 am - 10:50 amTYS-DSM
6h 20m1 stop
$343American Airlines
Find Deal
Mon, May 27 - Tue, May 28
4:02 pm - 11:58 pmDSM-TYS
6h 56m1 stop
7:40 pm - 12:05 amTYS-DSM
5h 25m1 stop
$350American Airlines
Find Deal
Wed, Jun 26 - Sun, Jun 30
6:00 am - 3:44 pmDSM-TYS
8h 44m2 stops
5:29 am - 11:15 amTYS-DSM
6h 46m2 stops
$351American Airlines
Find Deal
Sat, Aug 31 - Fri, Sep 6
6:04 am - 2:13 pmDSM-TYS
7h 09m2 stops
2:43 pm - 10:04 pmTYS-DSM
8h 21m2 stops
$381American Airlines
Find Deal
Tue, May 28 - Tue, Jun 4

Flights from Des Moines to Knoxville - Travel Insights & Trends

Get data-powered insights and trends into flights from Des Moines to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to Knoxville?

The average price of all flights from Des Moines to Knoxville clicked on KAYAK for each day over the last 12 months.
Your flight ticket price will generally be cheaper if you fly to Knoxville on a Saturday and more expensive on a Sunday. On your return trip to Des Moines, you should consider flying back on a Wednesday, and avoid Mondays for better deals.

What is the cheapest month to fly from Des Moines to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for flights from Des Moines to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.
The cheapest month for flights from Des Moines to Knoxville is January, where tickets cost $291 on average. On the other hand, the most expensive months are November and July, where the average cost of tickets is $493 and $458 respectively.

How far in advance should I book a flight from Des Moines to Knoxville?

To calculate daily average prices, KAYAK takes all prices for each day before departure over the last year for flights from Des Moines to Knoxville, removes the top 0.1% to account for outliers, and then takes the average of all the values for each month.
To get a below average price on the flight from Des Moines to Knoxville, you should book around 1 day before departure. For the absolute cheapest price, our data suggests you should book 87 days before departure.

Which airlines provide the cheapest flights from Des Moines to Knoxville?

The cheapest price for the route for each airline clicked by KAYAK users in the last 72 hours.
In the last 72 hours, the cheapest one-way ticket from Des Moines to Knoxville found on KAYAK was with Delta for $294. American Airlines proposed a round-trip connection from $216 and United Airlines from $266.

Good to know

Low season

January

High season

July

Cheapest flight

$216
Best time to beat the crowds with an average 26% drop in price.
Most popular time to fly with an average 16% increase in price.
Flight from Des Moines to Knoxville

When to book flights from Des Moines to Knoxville

Are your dates flexible? Find out the best times to travel from Des Moines to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Des Moines to Knoxville

  • What is the cheapest flight from Des Moines to Knoxville?

    In the last 3 days, the lowest price for a flight from Des Moines to Knoxville was $294 for a one-way ticket and $216 for a round-trip.

  • Do I need a passport to fly between Des Moines and Knoxville?

    No

  • Which airports will I be using when flying from Des Moines to Knoxville?

    On your way to Knoxville, you’ll fly out from Des Moines. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Des Moines to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Des Moines to Knoxville?

    SkyTeam, oneworld, and Star Alliance are the airline alliances operating flights between Des Moines and Knoxville, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Des Moines to Knoxville, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Des Moines to Knoxville are Delta and United Airlines. With an average price for the route of $422 and an overall rating of 8.0, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $419 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from Des Moines to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Des Moines is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Des Moines with another airline. Booking your flights between Des Moines and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Des Moines up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top 4 airlines serving from Des Moines to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10778 reviews
7.4Food
7.9Comfort
8.6Crew
8.0Entertainment
8.2Boarding
Airline reviews

The gate area was incredibly short staffed, with one representative manning 4-5 flights, which caused a 3 hr delay in boarding even though the plane was all ready to leave. Other flights also were delayed because of this. The flight crew was awesome and I feel bad for the only gate worker on call, but Delta needs to hire more employees.

2.0 MediocreAnonymous, May 2024AVL - LGA
Read more about Delta reviews

The gate area was incredibly short staffed, with one representative manning 4-5 flights, which caused a 3 hr delay in boarding even though the plane was all ready to leave. Other flights also were delayed because of this. The flight crew was awesome and I feel bad for the only gate worker on call, but Delta needs to hire more employees.

Very frustrated with boarding gate crew. She announced the plane was small and they would be limiting us to one item to carry on. Not a problem for me as I understand the tiny planes have limited space!! Not the case here! It was a rather large plane and had plenty of room for bags! So because I don’t want to be one of “those people” who ignores the request to check a carry on I did so asking if I would be able to pick it up at the bottom of the ramp on arrival in Knoxville to which she responded “yes”! Then I watched as every other passenger held onto their 2 items and boarded!! Then when we arrived in Knoxville our 2 carry ons had been put with all the other luggage and we had to go to baggage pick up and wait for all the big checked bags to come off the carousel! So she lied!! Frustrating. Next time I won’t be so nice!

It was a good experience except when boarding a female flight attendant did not go out of her way to assist my teenage daughters in finding space for their carry-ons after their compartments were full.

On time departure, smooth trip, flight attendant told through passengers the gate we would arrive at and the gate our outbound flight was departing from. Early arrival

Checking in at the airport the agent only booked the first keg of my trip and had my checked luggage going to the airport with a layover! Never was issued a boarding pass for the second leg or received sticker fir my checked bag. All was well in the end! Delta agents helped to resolve the situation!!!

Delayed due to an ill passenger after loading. Not preventable on Delta's part. Was in first class. The seats are becoming worn and detaching from their velcro attachments. Only got snacks on flight. The attendant was not the friendliest.

I would fly again the whole experience was great. The only feed back I can give that they don't do that American Airlines does is the crew there is more humorous with boarding and thank their passengers. It makes it more fun to fly with them. I would however fly Delta again.

From Atlanta to Cabo I would have hoped on a plane that size I would have been able to breathe and wiggle my feet a little! The leg room in that plane is non existent and I am only 5”4’. And the air vent either wasn’t working very well or just could not blow air from the ceiling to the seat area as I was suffocating through the entire flight! And please don’t say I would have been more comfortable in first class because I cannot afford those rates and have always travelled Main Cabin without issues !

The pilots were good. Disappointing when planes don't have electrical ports

I liked the piloting of the aircraft. Very disappointed about lack of electrical ports. Also, although a short flight. there was enough time to hand out snacks to comfort + seats as was done for first class.

The net issue I had was with the gate agent. We had added a carryon to our boarding pass when we checked bags. When I got to the boarding gate the agent was rude asking why I had a backpack - I said I added it - even had an orange tag on it. She ripped my tag off and swung her monitor around to show me how she was right- saying it isn’t wasn’t listed - only a checked bag. I explained again that I wasn’t sure what the issue was but I wouldn’t have an orange tag if I hadn’t added it. Then she finally checked my husband’s boarding pass and found that the agent at checkin had added my carryon to his boarding pass instead of mine. She sent me on my way without my orange tag. Was a bit embarrassing for me the tone she used with me assuming I was trying to get away with something.

Gate agent asked if I could switch seats so a family could sit together. Agent moved me to a seat in the front of the plane, no charge. It was easy. The agent did a great job.

Great seat space. However food and drink prices outrageous. Jabbing to pay for a carry on bag or stuck paying at the gate too much.

Every Allegiant Air flight I've ever taken has been delayed. This flight was delayed a full 2 hours. It was excuse after excuse after excuse. It was a flight from southern Florida. They made us board the plane on time, but made us wait for 2 hours on the tarmac. Because the engines were kept shut off, so was the air conditioning. One can only imagine how hot the air was in the cabin over those 2 hours on the tarmac, while in the hot Florida sun. Just terrible.

Actually, for the price, I'm willing to put up with a little discomfort (upright chairs) and at times inconveniences (like any airline), lack of entertainment (I can bring my own). My flight was non stop and smooth. I would fly this route again.

The flight was delayed 6 hours and we were only offered an $8 food credit. My husband stood in line to get the credit for 45 minutes and when he got close to the end of the line the computers went down.

Worst ever! Flight cancelled supposedly for weather even though we k ow of many others who flew into Bangor same time no problem. At the airport there was no customer service at all just refund and no possibility of rebook for 3-4 days. Aweful won’t fly with them again!!

It’s a budget airline so adjust expectations accordingly. Nothing is without a fee but such is necessary for tickets to remain so affordable.

No complaints. It’s a budget airline so can’t expect any frills.

My TSA number was missing from my ticket which shouldn’t have happened since it’s in my file. The on board flight attendant who was a male, did not want to help me put my luggage in the overhead bin and made a very rude comment and was very unpleasant. The good… the woman who fixed my ticket with the TSA number was excellent and I had extra legroom which was perfect.

Surprisingly easy! I was hesitant to try this, but the cost swayed me. I actually felt like I had less stress than all the taxiing and possible delays that occur with short regional flights where you spend less time in the air than getting to and from the plane..

This flight was delayed multiple times and eventually canceled around 2-3ish. Original take off time was around 10:30am. By 3, there were no other options out of Houston, so stuck in Houston for from 3pm - 11am the next day.

Should have video screens Plane audio was poor and without wired connection hard to understand crew. Should serve more than just cups of water and pretzels on six hour flight. Did not see crew rest of flight. Fix charging sockets to retain charging blocks.

I paid $380 for my one-way ticket from California to Minnesota. The fair did not include online check-in. I received instructions from their app to check in at a kiosk. At the kiosk, the boarding pass would not print until an actual person came to verify that I had a personal item and not a carry-on item, On the plane, the person next to me was drunk and allowed to continue to order alcohol. United is garbage I’d rather fly spirit.

The plane was dirty and the in seat air wasn't blowing as planes usually do.

Generally good but there wasn’t any staff available when my luggage didn’t appear at baggage claim in Fresno. It took about half an hour to locate a staff member to open up the locked room where it was being kept.

Do not like the feeling of being in the basic economy. Everyone should feel good no matter what.

All flights were on time and boarding was issue free

Terrible! The plane was old and you are required to connect your own device to their Wi-Fi rather than have entertainment options in the back of the seat in front of you. The Wi-Fi went out during the flight and there was only one plug for the devices every two seats. Three out of five surrounding my family did not work. The seats and spaces under them were so small I could not fit my backpack, which I’ve always brought on flights and fit before no problem. The crew were unpleasant and patronizing.

Great! The plane was decently sized and comfortable. The staff was nice and there was great in flight entertainment

Left from gate 30 minutes before flight. Never been late to a flight ever. It says 15 minutes before explicitly on the ticket.

I like the boarding process, it was fast. The seat doesn’t have a TV for a long flight and food wasn’t served, just snacks.

Use planes with TVs on flights over 4 hours. The free entertainment was a cheap in between solution for a very long flight that you don't even bother providing meals or decent snacks.

Even though we left CMI late, we mostly made up the time.

Delayed almost 4 hours for a 45 minute flight with no explanation.

Again, multiple delays and I eventually just canceled and drove!

Great crew. We were delayed so that late passengers could get on the flight. Love the bedding in business class. Good food. Great experience.

The CX617 from HK to BKK was delayed more than 1.5 hours.

Horrible - they lied to me about baggage & boarding, even though I specifically spoke to their agents the day before my flight about my issue. When I showed up they did not let me board and stranded me at my airport until I bought a new flight with money I did not have to spend.

All four American Airlines flights I took in last seven days were delayed. Caused me loads of problems, missed meetings, loss of time and money.

Book cheap flights from Des Moines to Knoxville

Recent one-way flight deals

 
Only flying one-way? Below are some of the best one-way flight deals from Des Moines to Knoxville found on KAYAK in the last 72 hours.
5/27Mon
1 stopDelta
7h 00mDSM-TYS
$294
5/27Mon
2 stopsAmerican Airlines
7h 09mDSM-TYS
$364

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Last minute flights from Des Moines to Knoxville

Last minute flight, train and bus deals

 
These last-minute flight deals are the cheapest flights found on KAYAK in the last 72 hours for flights from Des Moines to Knoxville that are departing in the next 10 days.
5/11Sat
multi-stopAmerican Airlines
4h 28mDSM-TYS
5/14Tue
multi-stopAmerican Airlines
4h 19mTYS-DSM
$366
5/12Sun
multi-stopDelta
7h 00mDSM-TYS
5/15Wed
multi-stopDelta
7h 16mTYS-DSM
$368
5/11Sat
multi-stopAmerican Airlines
9h 08mDSM-TYS
5/14Tue
multi-stopAmerican Airlines
7h 19mTYS-DSM
$371
5/12Sun
multi-stopAmerican Airlines
7h 11mDSM-TYS
5/15Wed
multi-stopAmerican Airlines
6h 41mTYS-DSM
$403
5/10Fri
multi-stopUnited Airlines
4h 22mDSM-TYS
5/15Wed
multi-stopUnited Airlines
4h 34mTYS-DSM
$408
5/11Sat
multi-stopDelta
4h 37mDSM-TYS
5/13Mon
multi-stopDelta
4h 30mTYS-DSM
$428
5/12Sun
multi-stopDelta
7h 00mDSM-TYS
5/12Sun
multi-stopDelta
4h 30mTYS-DSM
$443
5/11Sat
multi-stopAmerican Airlines
9h 08mDSM-TYS
5/14Tue
multi-stopAmerican Airlines
7h 17mTYS-DSM
$451
5/10Fri
multi-stopUnited Airlines
4h 22mDSM-TYS
5/16Thu
multi-stopUnited Airlines
4h 34mTYS-DSM
$473
5/11Sat
multi-stopUnited Airlines
14h 04mDSM-TYS
5/15Wed
multi-stopUnited Airlines
5h 16mTYS-DSM
$622

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Des Moines - Knoxville Flights

Departure:

Des Moines (undefined)United States

Destination:

Knoxville (TYS)United States

Return flight deals:

Knoxville - Des Moines

Cabin classes: