Which airports can I use when flying from Des Moines to Knoxville?

Flights from Des Moines to Knoxville usually depart from Des Moines (DSM) and arrive at Knoxville McGhee Tyson (TYS).

What cabin classes can I book on flights from Des Moines to Knoxville?

Only Economy Class is available on flights from Des Moines to Knoxville.

Which airports do connecting flights from Des Moines to Knoxville pass through?

One-stop flights from Des Moines to Knoxville most commonly connect through: • Chicago O'Hare Intl (ORD) - 57% of one-stop connections • Charlotte Douglas (CLT) - 17% of one-stop connections • Atlanta Hartsfield-Jackson (ATL) - 10% of one-stop connections • Detroit Metropolitan Wayne County (DTW) - 5% of one-stop connections

Can I save money by using flexible dates for flights from Des Moines to Knoxville?

Yes. Flexible dates can save you up to 46% on flights from Des Moines to Knoxville. Monday is the cheapest departure day at $287 round-trip on average, while Wednesday is the most expensive at $523, a difference of $236. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

How long is a flight from Des Moines to Knoxville?

A nonstop flight from Des Moines to Knoxville takes 00m, covering 654 miles.

Do I need a passport to fly from Des Moines to Knoxville?

No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

Have flight prices from Des Moines to Knoxville changed much recently?

Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $283 to $1,793. That means the highest observed fare was about 6x higher than the lowest one.

How are flight prices from Des Moines to Knoxville looking right now?

One-way fares from Des Moines to Knoxville are currently higher than usual. Average one-way flight prices are about $276, which is 31% above the typical average for this route.

How much time can I save by choosing a different layover airport from Des Moines to Knoxville?

Flying via Detroit Metropolitan Wayne County (DTW) gives the shortest average 1-stop total travel time at 4h 26m, compared with 4h 43m via Minneapolis St Paul (MSP) and 4h 53m via Chicago O'Hare Intl (ORD).

What is the time difference between Des Moines and Knoxville?

Knoxville is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include: • Budget • Alamo • Enterprise Rent-A-Car • Thrifty • Avis

How much should I expect to pay for a Des Moines to Knoxville flight?

Round-trip flights from Des Moines to Knoxville range from $299 to $446, with an average of $378 over the past 12 months. Anything below $299 counts as a good deal.

How much is a round-trip flight from Des Moines to Knoxville?

Round-trip flights from Des Moines to Knoxville typically range from $299 to $446. The lowest price found in the past 5 days was $283, on American Airlines.

What's the cheapest day of the week to fly from Des Moines to Knoxville?

Based on deals KAYAK users found in the last 12 months, Monday is the cheapest day of the week to fly from Des Moines to Knoxville. It’s 25% cheaper than the average day, while Wednesday is the most expensive, with prices 38% higher.

Which airline is the cheapest to fly from Des Moines to Knoxville?

American Airlines ($283) and Delta ($317) are the cheapest airlines to fly round-trip from Des Moines to Knoxville according to KAYAK data over the last 5 days.

What’s the most popular layover airport when flying from Des Moines to Knoxville?

Chicago O'Hare Intl (ORD) is the most popular layover for the Des Moines to Knoxville route. 57% of KAYAK users who booked 1-stop round-trips over the past 3 months connected via ORD.

What is the cheapest layover airport when flying from Des Moines to Knoxville?

Flights via Detroit Metropolitan Wayne County (DTW) offer the most affordable fares, with an average round-trip price of $203. Based on KAYAK data over the past 3 months.

When flying from Des Moines to Knoxville which airport offers the shortest layover?

Detroit Metropolitan Wayne County (DTW) had the shortest average connection time for Des Moines to Knoxville layovers at 2h 38m over the past 3 months.

$192 CHEAP FLIGHTS from Des Moines to Knoxville (DSM - TYS)

Save 25% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Cheapest round-trip

$283

Typical prices: $299-$446

American Airlines

Tue 12/4Fri 12/7

DSM - TYS • 1 stop

Cheapest one-way

$192

Typical prices: $159-$323

American Airlines

Thu 11/15

DSM - TYS • 1 stop

Nonstop flights

Not available

There are currently no direct flights between Des Moines and Knoxville. You'll need to take a connecting flight to reach the destination.

Insights

When to travel

November

Cheapest • 35% price drop

August

Most popular

Good to know

Top layover airports

Detroit Metropolitan Wayne County (DTW)

Cheapest • Avg $203 (round-trip)

Minneapolis St Paul (MSP)

Shortest trip • 4h 43m (one-way)

Insights

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KAYAK searches 100s of sites at once to find you the best travel deals.

We hope you love your trip to Knoxville!

Flight Deals

Cheap Flights from Des Moines to Knoxville (DSM-TYS)

Discover the best prices for you by selecting your travel dates on KAYAK.

Round-trip

One-way

Last minute

Recent round-trip flight deals from Des Moines to Knoxville

Fri, Dec 4 - Mon, Dec 7

3:31 pm - 11:40 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 09m1 stop Dallas/Fort Worth

8:46 pm - 12:33 amTYS Knoxville McGhee Tyson-DSM Des Moines

4h 47m1 stop Chicago O'Hare Intl

$283American Airlines

Fri, Dec 4 - Mon, Dec 7

3:31 pm - 11:40 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 09m1 stop Dallas/Fort Worth

8:46 pm - 12:33 amTYS Knoxville McGhee Tyson-DSM Des Moines

4h 47m1 stop Chicago O'Hare Intl

$283American Airlines

Thu, Dec 3 - Mon, Dec 7

6:53 pm - 11:57 pmDSM Des Moines-TYS Knoxville McGhee Tyson

4h 04m1 stop Atlanta Hartsfield-Jackson

7:26 pm - 10:38 pmTYS Knoxville McGhee Tyson-DSM Des Moines

4h 12m1 stop Atlanta Hartsfield-Jackson

$317Delta

Fri, Dec 4 - Mon, Dec 7

3:31 pm - 11:40 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 09m1 stop Dallas/Fort Worth

6:00 am - 10:20 amTYS Knoxville McGhee Tyson-DSM Des Moines

5h 20m1 stop Charlotte Douglas

$317American Airlines

Fri, Dec 4 - Mon, Dec 7

3:20 pm - 11:59 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 39m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

5:00 pm - 10:21 pmTYS Knoxville McGhee Tyson-DSM Des Moines

6h 21m1 stop Houston George Bush Intcntl

$369United Airlines

Thu, Dec 3 - Mon, Dec 7

9:30 am - 5:00 pmDSM Des Moines-TYS Knoxville McGhee Tyson

6h 30m1 stop Chicago O'Hare Intl

2:07 pm - 9:25 pmTYS Knoxville McGhee Tyson-DSM Des Moines

8h 18m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$369United Airlines

Thu, Dec 3 - Mon, Dec 7

7:00 am - 7:50 pmDSM Des Moines-TYS Knoxville McGhee Tyson

11h 50m2 stops Denver Intl Nashville Intl

7:05 am - 2:15 pmTYS Knoxville McGhee Tyson-DSM Des Moines

8h 10m2 stops Nashville Intl Denver Intl

$382Southwest

Sat, Apr 17 - Wed, Apr 21

6:30 pm - 11:46 pmDSM Des Moines-TYS Knoxville McGhee Tyson

4h 16m1 stop Atlanta Hartsfield-Jackson

12:00 pm - 5:42 pmTYS Knoxville McGhee Tyson-DSM Des Moines

6h 42m1 stop Atlanta Hartsfield-Jackson

$387Delta

Sat, Apr 17 - Sat, Apr 24

6:30 pm - 11:46 pmDSM Des Moines-TYS Knoxville McGhee Tyson

4h 16m1 stop Atlanta Hartsfield-Jackson

11:30 am - 4:50 pmTYS Knoxville McGhee Tyson-DSM Des Moines

6h 20m1 stop Detroit Metropolitan Wayne County

$387Delta

Mon, Apr 19 - Thu, Apr 22

6:30 am - 5:51 pmDSM Des Moines-TYS Knoxville McGhee Tyson

10h 21m1 stop Tampa St. Petersburg

2:19 pm - 10:23 pmTYS Knoxville McGhee Tyson-DSM Des Moines

9h 04m1 stop Fort Lauderdale

$392Allegiant Air

Recent last minute flight deals from Des Moines to Knoxville

Thu, Nov 5 - Tue, Nov 10

2:22 pm - 10:35 pmDSM Des Moines-TYS Knoxville McGhee Tyson

31h 13m2 stops Santa Ana J. Wayne/Orange Cnty Las Vegas Harry Reid Intl

8:30 am - 11:56 amTYS Knoxville McGhee Tyson-DSM Des Moines

28h 26m1 stop Orlando Sanford Intl

$663Multiple Airlines

Thu, Nov 5 - Tue, Nov 10

4:15 pm - 1:48 pmDSM Des Moines-TYS Knoxville McGhee Tyson

20h 33m1 stop Fort Lauderdale

8:30 am - 11:56 amTYS Knoxville McGhee Tyson-DSM Des Moines

28h 26m1 stop Orlando Sanford Intl

$708Allegiant Air

Mon, Nov 2 - Thu, Nov 5

1:27 pm - 10:32 pmDSM Des Moines-TYS Knoxville McGhee Tyson

8h 05m1 stop Denver Intl

1:51 pm - 7:16 pmTYS Knoxville McGhee Tyson-DSM Des Moines

6h 25m1 stop Chicago O'Hare Intl

$717United Airlines

Mon, Nov 2 - Thu, Nov 5

3:01 pm - 9:57 pmDSM Des Moines-TYS Knoxville McGhee Tyson

5h 56m1 stop Houston George Bush Intcntl

11:20 am - 7:16 pmTYS Knoxville McGhee Tyson-DSM Des Moines

8h 56m2 stops Newark Chicago O'Hare Intl

$722United Airlines

Mon, Nov 2 - Thu, Nov 5

6:05 am - 2:48 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 43m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

1:51 pm - 5:28 pmTYS Knoxville McGhee Tyson-DSM Des Moines

4h 37m1 stop Chicago O'Hare Intl

$722United Airlines

Mon, Nov 2 - Thu, Nov 5

6:05 am - 2:48 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 43m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl

9:45 am - 7:16 pmTYS Knoxville McGhee Tyson-DSM Des Moines

10h 31m2 stops Washington, D.C. Dulles Intl Chicago O'Hare Intl

$728United Airlines

Wed, Nov 4 - Sun, Nov 8

12:46 pm - 12:27 pmDSM Des Moines-TYS Knoxville McGhee Tyson

46h 41m2 stops Orlando Sanford Intl Key West

9:33 pm - 9:34 amTYS Knoxville McGhee Tyson-DSM Des Moines

13h 01m1 stop Tampa St. Petersburg

$735Allegiant Air

Sun, Nov 1 - Mon, Nov 2

7:06 am - 3:18 pmDSM Des Moines-TYS Knoxville McGhee Tyson

7h 12m1 stop Charlotte Douglas

5:19 pm - 11:26 pmTYS Knoxville McGhee Tyson-DSM Des Moines

7h 07m1 stop Charlotte Douglas

$767American Airlines

Wed, Nov 4 - Sun, Nov 8

6:00 am - 12:12 pmDSM Des Moines-TYS Knoxville McGhee Tyson

5h 12m1 stop Dallas/Fort Worth

8:04 pm - 11:57 pmTYS Knoxville McGhee Tyson-DSM Des Moines

4h 53m1 stop Charlotte Douglas

$768American Airlines

Sun, Nov 1 - Mon, Nov 2

5:25 am - 4:50 pmDSM Des Moines-TYS Knoxville McGhee Tyson

10h 25m2 stops Chicago Midway Orlando

12:50 pm - 11:00 pmTYS Knoxville McGhee Tyson-DSM Des Moines

11h 10m2 stops Orlando Chicago Midway

$777Southwest

Booking Insights

Price, demand and travel trends for Des Moines to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Prices

Airlines

Layovers

How much is a round-trip flight from Des Moines to Knoxville? This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Des Moines to Knoxville departing in december.
What's the cheapest day of the week to fly from Des Moines to Knoxville?: Based on deals KAYAK users found in the last 12 months, Monday is the cheapest day of the week to fly from Des Moines to Knoxville. It’s 25% cheaper than the average day, while Wednesday is the most expensive, with prices 38% higher.

Find deals

Low season	January
High season	August
Cheapest flight	$192

Beat the crowds with an average 67% drop in travelers.

The most popular month to fly with an average 75% increase in travelers.

One-way flight from Des Moines to Knoxville

When to book flights from Des Moines to Knoxville

Are your dates flexible? Find out the best times to travel from Des Moines to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.

Estimated round-trip price

KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

What cabin classes can I book on flights from Des Moines to Knoxville?
Only Economy Class is available on flights from Des Moines to Knoxville.
How long is a flight from Des Moines to Knoxville?
A nonstop flight from Des Moines to Knoxville takes 00m, covering 654 miles.
Do I need a passport to fly from Des Moines to Knoxville?
No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.
How much should I expect to pay for a Des Moines to Knoxville flight?
Round-trip flights from Des Moines to Knoxville range from $299 to $446, with an average of $378 over the past 12 months. Anything below $299 counts as a good deal.
Have flight prices from Des Moines to Knoxville changed much recently?
Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $283 to $1,793. That means the highest observed fare was about 6x higher than the lowest one.
How are flight prices from Des Moines to Knoxville looking right now?
One-way fares from Des Moines to Knoxville are currently higher than usual. Average one-way flight prices are about $276, which is 31% above the typical average for this route.
What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?
Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include:

• Budget
• Alamo
• Enterprise Rent-A-Car
• Thrifty
• Avis
Which airports can I use when flying from Des Moines to Knoxville?
Flights from Des Moines to Knoxville usually depart from Des Moines (DSM) and arrive at Knoxville McGhee Tyson (TYS).
Which airports do connecting flights from Des Moines to Knoxville pass through?
One-stop flights from Des Moines to Knoxville most commonly connect through:

• Chicago O'Hare Intl (ORD) - 57% of one-stop connections
• Charlotte Douglas (CLT) - 17% of one-stop connections
• Atlanta Hartsfield-Jackson (ATL) - 10% of one-stop connections
• Detroit Metropolitan Wayne County (DTW) - 5% of one-stop connections
Can I save money by using flexible dates for flights from Des Moines to Knoxville?
Yes. Flexible dates can save you up to 46% on flights from Des Moines to Knoxville. Monday is the cheapest departure day at $287 round-trip on average, while Wednesday is the most expensive at $523, a difference of $236.

KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.
How much time can I save by choosing a different layover airport from Des Moines to Knoxville?
Flying via Detroit Metropolitan Wayne County (DTW) gives the shortest average 1-stop total travel time at 4h 26m, compared with 4h 43m via Minneapolis St Paul (MSP) and 4h 53m via Chicago O'Hare Intl (ORD).
What is the time difference between Des Moines and Knoxville?
Knoxville is 1 hour ahead of Des Moines (Eastern Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

If your dates are flexible, aim for a Monday departure and avoid flying on Wednesday. On this route, Monday flights average $287, about $236 less than Wednesday fares (45% savings) based on the last 12 months.
If you can choose when to travel, plan your Des Moines to Knoxville trip for November. Fares historically average $246 round-trip in that month - typically $355 less than the most expensive month, which is September (based on the last 12 months).

More options for your flight from Des Moines to Knoxville

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DSM - TYS

$192 Find Cheap Flights from Des Moines to Knoxville - Compare and Save

Everything you should know

Cheap Flights from Des Moines to Knoxville (DSM-TYS)

Recent round-trip flight deals from Des Moines to Knoxville

Recent one-way flight deals from Des Moines to Knoxville

Recent last minute flight deals from Des Moines to Knoxville

Price, demand and travel trends for Des Moines to Knoxville flights

How much is a round-trip flight from Des Moines to Knoxville?

What's the cheapest day of the week to fly from Des Moines to Knoxville?

Which airline is the cheapest to fly from Des Moines to Knoxville?

What’s the most popular layover airport when flying from Des Moines to Knoxville?

What is the cheapest layover airport when flying from Des Moines to Knoxville?

When flying from Des Moines to Knoxville which airport offers the shortest layover?

Key details for Des Moines to Knoxville flights

Low season

High season

Cheapest flight

When to book flights from Des Moines to Knoxville

Your Des Moines to Knoxville flight questions, answered

Your guide to booking Des Moines to Knoxville flights

More options for your flight from Des Moines to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

Information on your arrival and departure airports

Cabin class types available on flights from Des Moines to Knoxville

Find direct flights to and from Des Moines and Knoxville

Flights from domestic origins to Knoxville

Flights to other popular destinations

Find deals for your return flight