TYS - DSM

$181 Find Cheap Flights from Knoxville to Des Moines - Compare and Save

1 adult
1 adult, Economy, 0 bags

Save 25% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Everything you should know

Cheapest round-trip
$303
Typical prices: $347-$612
American Airlines
Mon 12/3Fri 12/7
TYS - DSM • 1 stop
Cheapest one-way
$181
Typical prices: $188-$343
Delta
Thu 12/6
TYS - DSM • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Des Moines. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
January
Cheapest • 25% price drop
July
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Fort Lauderdale (FLL)
Cheapest • Avg $413 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 4h 23m (one-way)
Insights
Insights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Des Moines!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Des Moines (TYS-DSM)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Des Moines

Thu, Dec 3 - Mon, Dec 7
American Airlines Logo
6:50 am - 10:58 amTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 08m1 stop Charlotte Douglas
American Airlines Logo
8:00 am - 3:26 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 26m1 stop Charlotte Douglas
$303American Airlines
Fri, Dec 18 - Sun, Dec 20
American Airlines Logo
8:01 pm - 11:58 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 57m1 stop Charlotte Douglas
American Airlines Logo
6:16 pm - 11:53 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
4h 37m1 stop Charlotte Douglas
$332American Airlines
Wed, Dec 23 - Mon, Dec 28
American Airlines Logo
8:01 pm - 11:58 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 57m1 stop Charlotte Douglas
American Airlines Logo
7:58 pm - 11:02 amDSM  Des Moines-TYS Knoxville McGhee Tyson
14h 04m1 stop Chicago O'Hare Intl
$391American Airlines
Thu, Dec 3 - Mon, Dec 7
United Airlines Logo
6:00 am - 10:37 amTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 37m1 stop Chicago O'Hare Intl
United Airlines Logo
3:20 pm - 11:59 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
7h 39m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$408United Airlines
Thu, Dec 3 - Mon, Dec 7
United Airlines Logo
6:20 am - 2:14 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
8h 54m2 stops Newark Chicago O'Hare Intl
United Airlines Logo
3:20 pm - 11:59 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
7h 39m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$413United Airlines
Tue, Nov 17 - Sat, Nov 21
United Airlines Logo
1:56 pm - 5:28 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 32m1 stop Chicago O'Hare Intl
United Airlines Logo
1:27 pm - 10:32 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
8h 05m1 stop Denver Intl
$423United Airlines
Mon, Nov 16 - Wed, Nov 18
Delta Logo
6:10 pm - 10:35 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 25m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:30 am - 11:28 amDSM  Des Moines-TYS Knoxville McGhee Tyson
4h 58m1 stop Atlanta Hartsfield-Jackson
$437Delta
Mon, Nov 16 - Wed, Nov 18
American Airlines Logo
8:52 pm - 12:26 amTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 34m1 stop Chicago O'Hare Intl
American Airlines Logo
8:07 am - 1:42 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
4h 35m1 stop Charlotte Douglas
$437American Airlines
Mon, Nov 16 - Wed, Nov 18
Southwest Logo
7:05 am - 8:50 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
14h 45m2 stops Nashville Intl Denver Intl
Southwest Logo
6:00 am - 8:50 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
13h 50m2 stops Chicago Midway Baltimore/Washington
$447Southwest
Mon, Nov 16 - Wed, Nov 18
Southwest Logo
7:05 am - 8:50 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
14h 45m2 stops Nashville Intl Denver Intl
Southwest Logo
6:00 am - 4:40 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
9h 40m3 stops Chicago Midway Cleveland Hopkins Intl Orlando
$453Southwest
Booking Insights

Price, demand and travel trends for Knoxville to Des Moines flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Knoxville to Des Moines?

Round-trip flights from Knoxville to Des Moines typically range from $347 to $612. The lowest price found in the past 5 days was $303, on American Airlines.

What's the cheapest day of the week to fly from Knoxville to Des Moines?

Based on deals KAYAK users found in the last 12 months, Friday is the cheapest day of the week to fly from Knoxville to Des Moines. It’s 24% cheaper than the average day, while Monday is the most expensive, with prices 56% higher.

Find deals

Key details for Knoxville to Des Moines flights

Low season

January

Cheapest flight

$181
Beat the crowds with an average 58% drop in travelers.
The most popular month to fly with an average 57% increase in travelers.
One-way flight from Knoxville to Des Moines

When to book flights from Knoxville to Des Moines

Are your dates flexible? Find out the best times to travel from Knoxville to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Knoxville to Des Moines flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Knoxville to Des Moines?

    Only Economy Class is available on flights from Knoxville to Des Moines.

  • How long is a flight from Knoxville to Des Moines?

    A nonstop flight from Knoxville to Des Moines takes 00m, covering 654 miles.

  • Do I need a passport to fly from Knoxville to Des Moines?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Knoxville to Des Moines flight?

    Round-trip flights from Knoxville to Des Moines range from $347 to $612, with an average of $452 over the past 12 months. Anything below $347 counts as a good deal.

  • Have flight prices from Knoxville to Des Moines changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $303 to $1,037. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Knoxville to Des Moines looking right now?

    One-way fares from Knoxville to Des Moines are currently higher than usual. Average one-way flight prices are about $337, which is 38% above the typical average for this route.

  • What car rental options are available at Des Moines Airport (DSM)?

    Des Moines Airport (DSM) hosts 5 major car rental companies, with daily rates averaging $81 for economy cars. Top options include:

    • Hertz
    • Payless
    • Budget
    • Alamo
    • Avis

  • Which airports can I use when flying from Knoxville to Des Moines?

    Flights from Knoxville to Des Moines usually depart from Knoxville McGhee Tyson (TYS) and arrive at Des Moines (DSM).

  • Which airports do connecting flights from Knoxville to Des Moines pass through?

    One-stop flights from Knoxville to Des Moines most commonly connect through:

    • Chicago O'Hare Intl (ORD) - 59% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 19% of one-stop connections
    • Charlotte Douglas (CLT) - 16% of one-stop connections
    • Dallas/Fort Worth (DFW) - 3% of one-stop connections

  • Can I save money by using flexible dates for flights from Knoxville to Des Moines?

    Yes. Flexible dates can save you up to 51% on flights from Knoxville to Des Moines. Friday is the cheapest departure day at $347 round-trip on average, while Monday is the most expensive at $708, a difference of $361.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Knoxville to Des Moines?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 23m, compared with 4h 39m via Chicago O'Hare Intl (ORD) and 4h 45m via Charlotte Douglas (CLT).

  • What is the time difference between Knoxville and Des Moines?

    Des Moines is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Des Moines?

    Some of the most popular sights in Des Moines are UnityPoint Health - Des Moines, Science Center of Iowa and Hy Vee Hall. These are among the most viewed places in Des Moines on KAYAK.

Your guide to booking Knoxville to Des Moines flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Friday departure and avoid flying on Monday. On this route, Friday flights average $347, about $361 less than Monday fares (51% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Knoxville to Des Moines trip for January. Fares historically average $341 round-trip in that month - typically $611 less than the most expensive month, which is March (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Des Moines Airport.

    • Days Inn & Suites by Wyndham Des Moines Airport
    • Homewood Suites by Hilton - Des Moines Airport
    • Quality Inn & Suites Des Moines Airport

More options for your flight from Knoxville to Des Moines

Complete your trip to Des Moines with a hotel stay or car rental

Car rentals in Des Moines
Hotels in Des Moines
Vacations in Des Moines