TYS - DSM

$97 Find Cheap Flights from Knoxville to Des Moines

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Des Moines departing on 6/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Des Moines

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Des Moines, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Des Moines, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$279
United Airlines
Wed 4/8Wed 4/15
TYS - DSM • 1 stop
Cheapest one-way
$97
Typical prices: $171-$199
Allegiant Air
Thu 6/4
TYS - DSM • 1 stop
Top airlines
Cheapest • from $279 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Des Moines. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $343 (round-trip)
Shortest trip • 4h 31m (one-way)
Insights
Insights
Insights
Insights
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Des Moines!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Des Moines (TYS-DSM)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Des Moines that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Des Moines

Wed, Apr 8 - Wed, Apr 15
United Airlines Logo
5:15 pm - 10:43 pm
TYS
-
DSM
6h 28m
1 stop
United Airlines Logo
3:21 pm - 11:08 pm
DSM
-
TYS
6h 47m
1 stop
$279United Airlines
Wed, Apr 8 - Wed, Apr 15
American Airlines Logo
5:00 am - 11:30 am
TYS
-
DSM
7h 30m
2 stops
American Airlines Logo
2:16 pm - 9:21 pm
DSM
-
TYS
6h 05m
1 stop
$304American Airlines
Sat, May 9 - Wed, May 20
American Airlines Logo
7:53 am - 1:46 pm
TYS
-
DSM
6h 53m
1 stop
American Airlines Logo
1:25 pm - 9:40 pm
DSM
-
TYS
7h 15m
1 stop
$311American Airlines
Sat, May 9 - Wed, May 20
American Airlines Logo
7:00 am - 1:46 pm
TYS
-
DSM
7h 46m
2 stops
American Airlines Logo
1:25 pm - 9:40 pm
DSM
-
TYS
7h 15m
1 stop
$316American Airlines
Thu, Apr 9 - Thu, Apr 16
Allegiant Air Logo
6:00 am - 1:46 pm
TYS
-
DSM
8h 46m
1 stop
Allegiant Air Logo
8:30 am - 8:42 pm
DSM
-
TYS
11h 12m
1 stop
$334Allegiant Air
Wed, Apr 8 - Wed, Apr 15
Southwest Logo
7:05 am - 2:05 pm
TYS
-
DSM
8h 00m
2 stops
Southwest Logo
5:30 am - 7:40 pm
DSM
-
TYS
13h 10m
2 stops
$340Southwest
Thu, Mar 26 - Mon, Mar 30
Allegiant Air Logo
7:00 am - 1:29 pm
TYS
-
DSM
7h 29m
1 stop
Allegiant Air Logo
2:15 pm - 10:51 pm
DSM
-
TYS
7h 36m
1 stop
$347Allegiant Air
Sat, May 9 - Wed, May 20
Southwest Logo
6:40 am - 1:30 pm
TYS
-
DSM
7h 50m
2 stops
Southwest Logo
5:30 am - 5:10 pm
DSM
-
TYS
10h 40m
2 stops
$350Southwest
Thu, Mar 26 - Mon, Mar 30
Multiple Airlines Logo
7:00 am - 1:29 pm
TYS
-
DSM
7h 29m
1 stop
Multiple Airlines Logo
7:22 pm - 12:45 pm
DSM
-
TYS
40h 23m
2 stops
$379Multiple Airlines
Sat, Apr 11 - Mon, Apr 13
United Airlines Logo
9:00 am - 2:22 pm
TYS
-
DSM
6h 22m
1 stop
United Airlines Logo
3:21 pm - 10:34 pm
DSM
-
TYS
6h 13m
1 stop
$381United Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Des Moines flights

Get data-powered insights and trends into flights from Knoxville to Des Moines to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Knoxville to Des Moines?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Knoxville to Des Moines were found on United Airlines ($279) and American Airlines ($304).

Good to know

Low seasonFebruary
Cheapest flight$97
Best time to beat the crowds with an average 33% drop in price.
Most popular time to fly with an average 5% increase in price.
Flight from Knoxville to Des Moines

When to book flights from Knoxville to Des Moines

Are your dates flexible? Find out the best times to travel from Knoxville to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Des Moines

  • What is the cheapest flight from Knoxville to Des Moines?

    In the last 3 days, the lowest price for a flight from Knoxville to Des Moines was $97 for a one-way ticket and $279 for a round-trip.

  • Do I need a passport to fly between Knoxville and Des Moines?

    No, a passport isn't needed to fly from Knoxville to Des Moines. However, local authorities might ask for an official ID.

  • Which aircraft models fly most regularly from Knoxville to Des Moines?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Des Moines?

    SkyTeam, and oneworld are the airline alliances operating flights between Knoxville and Des Moines, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Des Moines, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Des Moines are Delta and American Airlines. With an average price for the route of $332 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $387 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Knoxville to Des Moines?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Des Moines.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Des Moines?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Des Moines from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Des Moines?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Des Moines with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and DSM can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Des Moines?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Des Moines from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Des Moines

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Des Moines. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Des Moines? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8296 reviews
7.8Entertainment
8.5Crew
8.1Boarding
7.9Comfort
7.2Food
Airline reviews

First class is comfortable. Enjoyed a movie and was able to relax compared to coach.

10.0 ExcellentAnonymous, Mar 2026
ATL - DTW
Read more Delta reviews

First class is comfortable. Enjoyed a movie and was able to relax compared to coach.

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

The WiFi was not working. That made for a long flight.

Absolutely no communication on why there's a delay and multiple flight time reschedules. I would have canceled the flight and drove back home if I known it was going to be rescheduled 3 or 4 times.

Another late night flight and MORE men belligerently drinking and yelling. I had to move from first to economy because they were so obnoxious and disruptive. Crazy to go from a cozy chair to cardboard when you were supposed to be in first. Delta allows was too much drinking which leads to belligerent behavior.

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Love delta smaller commuter plane so no entertainment and paid wifi on MKE-LGA leg was extremely unreliable and slow

Stop changing gates. Stop cancelling flights Stop moving my seat.

Extremely disappointed with Delta. They canceled flight last minute and then I rebooked the other flights and with which were delayed as well

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

Easy boarding. Rows are smaller but that may be an older and bigger me now :)

It would have been nice if American tried to care.

American Airlines did everything they could with the high Spring Break crowd. I was frustrated to be changed from 1st class to a middle seat at the back of the plane. This has happened before, not sure booking 1st class and paying the extra actually works.

I booked 1st class, my flights were changed and I was sitting in the middle at the back of the plane. A far cry from the 1st class I purchased for my flights. I am grateful I arrived on time.

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Our flight was delayed 3 times and this is why I am giving such low reviews. Everything else was okay but being in the airport at 4:30pm for my initial flight at 7pm to not leave until after 9:30pm is insane,

Flights were constantly delayed. CRW took 50 minutes to get bags

Flight has been delayed every time I've ever taken it. Seats uncomfortable. Children behind me yelling the entire flight. Some of this is out of their control but overall just consistently not a great experience.

Everything you need to know for your flight from Knoxville to Des Moines

Information on your arrival and departure airports