TYS - DSM

$155 Find Cheap Flights from Knoxville to Des Moines

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Des Moines departing on 12/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Des Moines

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Des Moines, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Des Moines, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Knoxville to Des Moines (TYS-DSM)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Des Moines that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Des Moines

Thu, Nov 13 - Mon, Nov 17
Allegiant Air Logo
9:00 am - 2:01 pmTYS-DSM
6h 01m1 stop
Allegiant Air Logo
8:00 am - 1:01 pmDSM-TYS
28h 01m1 stop
$225Allegiant Air
Find Deal
Mon, Nov 24 - Thu, Nov 27
Allegiant Air Logo
9:29 pm - 11:24 pmTYS-DSM
26h 55m1 stop
Allegiant Air Logo
9:00 am - 5:29 pmDSM-TYS
7h 29m1 stop
$254Allegiant Air
Find Deal
Wed, Nov 12 - Sun, Nov 16
Allegiant Air Logo
4:32 pm - 10:00 amTYS-DSM
18h 28m1 stop
Allegiant Air Logo
2:51 pm - 9:25 amDSM-TYS
17h 34m1 stop
$268Allegiant Air
Find Deal
Tue, Dec 9 - Sat, Dec 13
American Airlines Logo
5:24 am - 10:29 amTYS-DSM
6h 05m1 stop
American Airlines Logo
8:50 am - 5:12 pmDSM-TYS
7h 22m1 stop
$271American Airlines
Find Deal
Tue, Dec 9 - Sat, Dec 13
American Airlines Logo
8:06 am - 11:42 amTYS-DSM
4h 36m1 stop
American Airlines Logo
6:00 am - 2:29 pmDSM-TYS
7h 29m2 stops
$276American Airlines
Find Deal
Thu, Nov 13 - Mon, Nov 17
Multiple Airlines Logo
9:00 am - 2:01 pmTYS-DSM
6h 01m1 stop
Multiple Airlines Logo
8:40 am - 10:34 amDSM-TYS
24h 54m3 stops
$311Multiple Airlines
Find Deal
Tue, Nov 25 - Tue, Dec 2
United Airlines Logo
5:45 am - 12:14 pmTYS-DSM
7h 29m2 stops
United Airlines Logo
8:00 am - 1:17 pmDSM-TYS
4h 17m1 stop
$318United Airlines
Find Deal
Tue, Nov 25 - Tue, Dec 2
United Airlines Logo
8:50 am - 4:12 pmTYS-DSM
8h 22m1 stop
United Airlines Logo
8:00 am - 1:17 pmDSM-TYS
4h 17m1 stop
$324United Airlines
Find Deal
Fri, Nov 14 - Mon, Nov 17
Delta Logo
5:34 pm - 9:15 pmTYS-DSM
4h 41m1 stop
Delta Logo
2:17 pm - 7:02 pmDSM-TYS
3h 45m1 stop
$359Delta
Find Deal
Thu, Nov 13 - Mon, Nov 17
Multiple Airlines Logo
5:38 pm - 2:55 pmTYS-DSM
22h 17m3 stops
Multiple Airlines Logo
1:37 pm - 10:34 amDSM-TYS
19h 57m2 stops
$380Multiple Airlines
Find Deal

Everything you should know

Top airlines
Allegiant Air
Cheapest • from $225 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
September
Cheapest • 33% price drop
July
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Cheapest round-trip
$225
Overall average: $452
Allegiant Air
Thu 11/13Mon 11/17
TYS - DSM • 1 stop
Cheapest one-way
$155
Typical prices: $188-$241
Allegiant Air
Sun 12/21
TYS - DSM • 1 stop
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Des Moines!
Booking Insights

KAYAK's insights & trends for Knoxville to Des Moines flights

Get data-powered insights and trends into flights from Knoxville to Des Moines to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Knoxville to Des Moines?

The average price of all round-trip flights from Knoxville to Des Moines clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Des Moines on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Monday is the most expensive day to fly from Knoxville to Des Moines. For your return ticket, we recommend flying on a Saturday and avoiding Mondays for the best deals.

What is the cheapest month to fly from Knoxville to Des Moines?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Des Moines, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Des Moines is September, where tickets cost $248 (return) on average. On the other hand, the most expensive months are March and November, where the average cost of round-trip tickets is $714 and $452 respectively.

Good to know

Low seasonJune
Cheapest flight$155
Best time to beat the crowds with an average 9% drop in price.
Most popular time to fly and prices are also 19% lower on average.
Flight from Knoxville to Des Moines

When to book flights from Knoxville to Des Moines

Are your dates flexible? Find out the best times to travel from Knoxville to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Des Moines

  • What is the cheapest flight from Knoxville to Des Moines?

    In the last 3 days, the lowest price for a flight from Knoxville to Des Moines was $155 for a one-way ticket and $225 for a round-trip.

  • Do I need a passport to fly between Knoxville and Des Moines?

    No, a passport isn't needed to fly from Knoxville to Des Moines. However, local authorities might ask for an official ID.

  • Which aircraft models fly most regularly from Knoxville to Des Moines?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Des Moines?

    SkyTeam, and oneworld are the airline alliances operating flights between Knoxville and Des Moines, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Des Moines, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Des Moines are Delta and American Airlines. With an average price for the route of $283 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $340 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Knoxville to Des Moines?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Des Moines.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Des Moines?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Des Moines from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Des Moines?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Des Moines with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and DSM can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Des Moines?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Des Moines from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Des Moines

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Des Moines. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Des Moines? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7996 reviews
8.5Crew
7.3Food
8.2Boarding
7.9Comfort
7.9Entertainment
Airline reviews

Everything went well and was good. Nothing exceptional, but no complaints either. Cheap seats are pretty comfortable.

8.0 ExcellentPAULINA, Oct 2025LAS - ATL
Read more Delta reviews

Everything went well and was good. Nothing exceptional, but no complaints either. Cheap seats are pretty comfortable.

Staff were friendly and happy. Delta could make sure passengers that don't have the app know of changes. Without Kayak I would not have known about the change of gate or the delay. Kayak was faster to notify me.

They ended up paying for the bag twice, but the counter wouldn't take my baggage receipt. Left it to me to resolve. Not sure how to resolve the issue.

The customer service before board was very rude and when I expressed my concerns about making the connecting flight she laughed and told me I bought the wrong ticket. I explained once it showed the flight was delayed it no longer let me change seats or anything. I was trying to upgrade to make sure I would get to the next gate on time.

Non stop on long haul is the way to go. Great experience

The flight used a B767 with a very old interior from before 2014. The entertainment system did not work at all during the flight despite attempts to reset the system. It was like they flew this route just to be competitive.

They changed planes and the new plane couldn’t carry enough fuel to fly across the country so we had to stop in Kansas City to refuel. Flight was delayed .

Flight was too crowded and seats are too small, especially since passengrs are getting larger. Having a middle seat is ALWAYS tough! Woman on my left was large & kept creeping in to my space. Flight personnel were great! Have more savory rather than sweet snacks please.

Flight was crowded and the woman sitting on my left was large & kept crouching in to my space. You need bigger seats or smaller passengers to fit into the seats you DO have! Snack were OK. Would appreciate if airlines had more savory rather than sweet snacks, thank you!

Delayed flight (1hour) plus a long layover after an overnight flight with no backup plane available.

Wish some foods provided rather than just biscuit/cookie for flight more than 2 hours

Wish a flight with more than 2 hours with some snack rather than just cookie/biscuit.

The flight attendant, a black woman with curly hair who sat near Row 21, was wonderful and kind.

It was good..clean, comfy seat. Friendly warm welcoming crew. Was able to check my cabin luggage at the gate which I was able to pickup in a decent time from baggage claim. The app gave all updates from delays to baggage claim info. Overall smooth flight.

Flight was delayed leaving Dallas. Arrived about 2 hours later than scheduled.

Flight delayed and missed connection. Rescheduled flight cancelled after 6 hrs wait. Rerouted thru ORD, flight cancelled, overnight stay in ORD. Still in the air on new flight!

We are too tired and frustrated to comment politely at this point

Terrible. Our luggage was delayed and couldn’t be delivered for several days. We got bad information from the airline agents at baggage claim. We had to pick up our car so we wouldn’t be charged for an extra day. We got lost in the maze of airport parking. The baggage claim agents didn’t offer us any compensation for our extra time and expense. We are tired, hungry and very frustrated.

The flight was flawless and we even arrived between 20 and 25 minutes early!

The only thing to like was that we eventually got to our destination

Everything you need to know for your flight from Knoxville to Des Moines

Information on your arrival and departure airports

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