TYS - DSM

$359 Find Cheap Flights from Knoxville to Des Moines

This is the cheapest round-trip flight price found by a KAYAK user in the last 72 hours by searching for a flight from Knoxville to Des Moines departing on 12/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Des Moines

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Des Moines, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Knoxville to Des Moines, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$359
Overall average: $407
Delta
Tue 12/30Sat 1/3
TYS - DSM • 1 stop
Cheapest one-way
Multiple Airlines
Tue 12/16
TYS - DSM • multi-stop
Top airlines
Allegiant Air
Cheapest • from $425 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
September
Cheapest • 33% price drop
July
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Des Moines!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Des Moines (TYS-DSM)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Knoxville to Des Moines that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Des Moines

Tue, Dec 30 - Sat, Jan 3
Delta Logo
7:05 am - 10:38 am
TYS
-
DSM
4h 33m1 stop
Delta Logo
5:55 pm - 11:13 pm
DSM
-
TYS
4h 18m1 stop
$359Delta
Sun, Dec 28 - Wed, Dec 31
Allegiant Air Logo
12:31 pm - 3:40 pm
TYS
-
DSM
28h 09m2 stops
Allegiant Air Logo
1:45 pm - 9:07 pm
DSM
-
TYS
6h 22m1 stop
$425Allegiant Air
Sun, Dec 28 - Wed, Dec 31
Allegiant Air Logo
10:04 pm - 10:03 am
TYS
-
DSM
12h 59m1 stop
Allegiant Air Logo
1:45 pm - 9:07 pm
DSM
-
TYS
6h 22m1 stop
$463Allegiant Air
Tue, Dec 30 - Sat, Jan 3
American Airlines Logo
5:00 am - 1:03 pm
TYS
-
DSM
9h 03m2 stops
American Airlines Logo
6:57 pm - 10:50 am
DSM
-
TYS
14h 53m1 stop
$485American Airlines
Sat, Dec 27 - Tue, Dec 30
American Airlines Logo
5:08 pm - 8:15 am
TYS
-
DSM
16h 07m1 stop
American Airlines Logo
6:52 pm - 10:50 am
DSM
-
TYS
14h 58m1 stop
$505American Airlines
Sat, Dec 27 - Tue, Dec 30
United Airlines Logo
5:45 am - 2:33 pm
TYS
-
DSM
9h 48m2 stops
United Airlines Logo
6:46 pm - 10:17 am
DSM
-
TYS
14h 31m1 stop
$564United Airlines
Sun, Dec 28 - Wed, Dec 31
American Airlines Logo
5:23 am - 10:47 am
TYS
-
DSM
6h 24m1 stop
American Airlines Logo
2:07 pm - 7:41 pm
DSM
-
TYS
4h 34m1 stop
$567American Airlines
Sun, Dec 28 - Wed, Dec 31
United Airlines Logo
11:00 am - 2:33 pm
TYS
-
DSM
4h 33m1 stop
United Airlines Logo
8:00 am - 7:51 pm
DSM
-
TYS
10h 51m2 stops
$608United Airlines
Sat, Dec 27 - Tue, Dec 30
United Airlines Logo
5:45 am - 2:33 pm
TYS
-
DSM
9h 48m2 stops
United Airlines Logo
3:14 pm - 11:59 pm
DSM
-
TYS
7h 45m2 stops
$619United Airlines
Sun, Dec 28 - Wed, Dec 31
United Airlines Logo
5:45 am - 2:33 pm
TYS
-
DSM
9h 48m2 stops
United Airlines Logo
8:00 am - 7:51 pm
DSM
-
TYS
10h 51m2 stops
$643United Airlines
Booking Insights

KAYAK's insights & trends for Knoxville to Des Moines flights

Get data-powered insights and trends into flights from Knoxville to Des Moines to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Knoxville to Des Moines?

The average price of all round-trip flights from Knoxville to Des Moines clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Des Moines on a Thursday, as we generally find the cheapest rates on that day for this route. On the other hand, Monday is the most expensive day to fly from Knoxville to Des Moines. For your return ticket, we recommend flying on a Saturday and avoiding Mondays for the best deals.

What is the cheapest month to fly from Knoxville to Des Moines?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Knoxville to Des Moines, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Knoxville to Des Moines is September, where tickets cost $248 (return) on average. On the other hand, the most expensive months are March and October, where the average cost of round-trip tickets is $757 and $421 respectively.

Good to know

Low seasonApril
Cheapest flight$359
Best time to beat the crowds with an average 9% drop in price.
Most popular time to fly and prices are also 24% lower on average.
Flight from Knoxville to Des Moines

When to book flights from Knoxville to Des Moines

Are your dates flexible? Find out the best times to travel from Knoxville to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Knoxville to Des Moines

  • What is the cheapest flight from Knoxville to Des Moines?

    In the last 3 days, the lowest price for a flight from Knoxville to Des Moines was $315 for a round-trip ticket.

  • Do I need a passport to fly between Knoxville and Des Moines?

    No, a passport isn't needed to fly from Knoxville to Des Moines. However, local authorities might ask for an official ID.

  • Which aircraft models fly most regularly from Knoxville to Des Moines?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Knoxville to Des Moines?

    SkyTeam, and oneworld are the airline alliances operating flights between Knoxville and Des Moines, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from Knoxville to Des Moines, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Knoxville to Des Moines are Delta and American Airlines. With an average price for the route of $283 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $343 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Knoxville to Des Moines?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Knoxville to Des Moines.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Knoxville to Des Moines?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Des Moines from Knoxville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Knoxville to Des Moines?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Des Moines with an airline and back to Knoxville with another airline. Booking your flights between Knoxville and DSM can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Knoxville to Des Moines?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Des Moines from Knoxville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Knoxville to Des Moines

 
See real verified KAYAK customer reviews for airlines flying from Knoxville to Des Moines. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Knoxville to Des Moines? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8008 reviews
8.1Boarding
7.9Entertainment
8.5Crew
7.9Comfort
7.3Food
Airline reviews

I noticed that the planes seem to be outdated. There was no entertainment per se. Also, the waiting area did not have any working electrical outlets

10.0 ExcellentMargaret, Dec 2025
BOS - PIT
Read more Delta reviews

I noticed that the planes seem to be outdated. There was no entertainment per se. Also, the waiting area did not have any working electrical outlets

Original flight was cancelled and when i was rebooked by the airline, they couldn't seat me in the same type of seat as I had originally booked (went from window/aisle to middle/middle and one was a bulkhead seat, and other wasn't in the same class)

Lady Pilot was perfect in every way wheels up to wheels down communication, professionalism, excellent on time departure and on time arrival, excellent communication! Fantastic job with Superb attitude!!

The food is terrible. The staff is wonderful. Comfort is good.

Left on time, a bit delayed due to headwinds most of the trip.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

Good seats in Main cabin, excellent service and excellent landing

My flight was cancelled with no explanation after I had already cleared security. I was given 4 options to rebook, only one being non-stop like I had paid for. I grabbed it. It was 4 plus hours later and then took off even later. Biggest complaint is that I booked early and had an aisle seat. They gave me a "window" seat in front of the exit row, so the seat did not decline. I weigh all of 103 #s and it was tight for me! For what I paid, I feel I was kind of ripped off. I think they should have given me the empty comfort seat for the inconvenience. There was no apology nor any explanation as to why the flight was cancelled. My guess is it benefitted Delta in some way.

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

Staff was exceptional! Everyone was kind, professional and friendly making the trip very pleasant. Thank you!

Gate was overcrowded. Gate agents performed very well. Flight crew was top notch! Efficient & professional & courteous. Both meals not thermalized well. Dinner main dish was actually cold in the center. Almost inedible. Breakfast sandwich was lukewarm.

The boarding was as always, the crew tried their best but not enough. The food was a disaster I had dietary restrictions that were half met because the company did not loaded the food for the flight. The entertainment screen was fine but content was not and also they removed the free messaging option from the flight and they charged 30 dollars for that crappy bandwidth. This flight is not worth the cost and the company is going down on quality.

Awful. They won’t help me with anything. I booked on American but they abdicated to Iberia. The ticket was overpriced. Everything negative

it was fine, decent flight... dont get food besides cookies or pretzels so not sure why you ask about food. same for entertainment..

I got sick nothing contagious but distressing and the care I received by Kayla? Keighly the flight attendant will be memorable for ever. Thank You

I got sick nothing contagious but distressing enough and the care I received on the flight was astounding.

Waaay too small plane. They also need to up the size of the overhead bins. I would love to keep me 3k with of camera equipment in my hard case baggahe instead of it being thrown into the belly of the plane

Attendants were pleasant and the flight was smooth and relaxed.

A little late at the start but all worked out well.

It was fine. No drinks nor snacks offered though. I thought that was unusual.

Everything you need to know for your flight from Knoxville to Des Moines

Information on your arrival and departure airports