TYS - DSM

$184 Find Cheap Flights from Knoxville to Des Moines - Compare and Save

1 adult
1 adult, Economy, 0 bags

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Everything you should know

Cheapest round-trip
$239
Typical prices: $343-$555
Delta
Sat 10/13Sat 10/20
TYS - DSM • 1 stop
Cheapest one-way
$184
Typical prices: $218-$333
Delta
Wed 9/26
TYS - DSM • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Des Moines. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
September
Cheapest • 22% price drop
July
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Fort Lauderdale (FLL)
Cheapest • Avg $413 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 4h 27m (one-way)
Insights
Insights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Des Moines!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Des Moines (TYS-DSM)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Des Moines

Tue, Oct 13 - Tue, Oct 20
Delta Logo
5:18 pm - 8:40 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
4h 22m1 stop Detroit Metropolitan Wayne County
Delta Logo
3:03 pm - 8:08 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
4h 05m1 stop Atlanta Hartsfield-Jackson
$239Delta
Fri, Oct 23 - Sat, Oct 31
United Airlines Logo
6:00 am - 10:31 amTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 31m1 stop Chicago O'Hare Intl
United Airlines Logo
9:36 am - 4:59 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 23m1 stop Chicago O'Hare Intl
$271United Airlines
Fri, Oct 23 - Sat, Oct 31
United Airlines Logo
6:00 am - 10:31 amTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 31m1 stop Chicago O'Hare Intl
United Airlines Logo
9:36 am - 7:36 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
9h 00m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$276United Airlines
Tue, Oct 27 - Mon, Nov 2
American Airlines Logo
6:20 am - 12:23 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
7h 03m1 stop Charlotte Douglas
American Airlines Logo
3:31 pm - 11:32 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
7h 01m1 stop Dallas/Fort Worth
$321American Airlines
Tue, Oct 13 - Tue, Oct 20
United Airlines Logo
6:00 am - 10:31 amTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 31m1 stop Chicago O'Hare Intl
United Airlines Logo
6:00 am - 2:42 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
7h 42m2 stops Chicago O'Hare Intl Washington, D.C. Dulles Intl
$324United Airlines
Wed, Sep 30 - Sun, Oct 4
Multiple Airlines Logo
4:14 pm - 9:02 amTYS  Knoxville McGhee Tyson-DSM Des Moines
17h 48m1 stop Fort Lauderdale
Multiple Airlines Logo
6:40 am - 5:57 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
34h 17m2 stops Philadelphia Orlando
$354Multiple Airlines
Tue, Sep 29 - Sat, Oct 3
American Airlines Logo
7:15 am - 1:43 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
7h 28m1 stop Washington, D.C. Reagan-National
American Airlines Logo
6:41 am - 2:29 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 48m1 stop Dallas/Fort Worth
$367American Airlines
Tue, Oct 13 - Tue, Oct 20
Delta Logo
6:23 pm - 10:33 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
5h 10m1 stop Atlanta Hartsfield-Jackson
Delta Logo
3:03 pm - 10:22 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
6h 19m1 stop Atlanta Hartsfield-Jackson
$367Delta
Tue, Oct 13 - Tue, Oct 20
American Airlines Logo
6:20 am - 12:23 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
7h 03m1 stop Charlotte Douglas
American Airlines Logo
1:14 pm - 9:14 pmDSM  Des Moines-TYS Knoxville McGhee Tyson
7h 00m1 stop Charlotte Douglas
$367American Airlines
Thu, Oct 1 - Sun, Oct 4
Allegiant Air Logo
2:06 pm - 9:31 pmTYS  Knoxville McGhee Tyson-DSM Des Moines
8h 25m1 stop Sarasota Bradenton Intl
Allegiant Air Logo
1:37 pm - 10:35 amDSM  Des Moines-TYS Knoxville McGhee Tyson
19h 58m1 stop Fort Lauderdale
$368Allegiant Air
Booking Insights

Price, demand and travel trends for Knoxville to Des Moines flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Knoxville to Des Moines with more confidence.

How much is a round-trip flight from Knoxville to Des Moines?

Round-trip flights from Knoxville to Des Moines start at $239. Prices are below average for this route right now, with typical round-trip fares ranging from $343 to $555. The lowest price found in the past 5 days was $239 on Delta.

What's the cheapest day of the week to fly from Knoxville to Des Moines?

Friday is the cheapest day of the week to fly from Knoxville to Des Moines, it is 15% cheaper than the average day. Saturday is the most expensive day with flight prices 114% higher than average. Based on deals found by KAYAK users in the last 12 months.

Find deals

Key details for Knoxville to Des Moines flights

Low season

January

Cheapest flight

$184
Best time to beat the crowds with an average 16% drop in price.
Most popular time to fly with an average 46% increase in price.
Flight from Knoxville to Des Moines

When to book flights from Knoxville to Des Moines

Are your dates flexible? Find out the best times to travel from Knoxville to Des Moines based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Knoxville to Des Moines flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Knoxville to Des Moines?

    Flights from Knoxville to Des Moines usually depart from Knoxville McGhee Tyson (TYS) and arrive at Des Moines (DSM).

  • What cabin classes can I book on flights from Knoxville to Des Moines?

    Only Economy Class is available on flights from Knoxville to Des Moines.

  • Which airports do connecting flights from Knoxville to Des Moines pass through?

    One-stop flights from Knoxville to Des Moines most commonly connect through:

    • Chicago O'Hare Intl (ORD) - 65% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 18% of one-stop connections
    • Charlotte Douglas (CLT) - 12% of one-stop connections
    • Dallas/Fort Worth (DFW) - 3% of one-stop connections

    Chicago O'Hare Intl (ORD) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Knoxville to Des Moines?

    Yes. Being flexible with your travel dates can save you up to 60% on the Knoxville to Des Moines route. Friday is the cheapest departure day at $347 round-trip on average, while Saturday is the most expensive at $867, a difference of $520. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • What popular places can I visit in Des Moines?

    Some of the most popular sights in Des Moines are UnityPoint Health - Des Moines, Science Center of Iowa and Hy Vee Hall. These are among the most viewed places in Des Moines on KAYAK.

  • How long is a flight from Knoxville to Des Moines?

    A nonstop flight from Knoxville to Des Moines takes 0h 00m, covering 654 miles.

  • Do I need a passport to fly from Knoxville to Des Moines?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Knoxville to Des Moines changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $239 to $829. That means the highest observed fare was about 3x higher than the lowest one.

  • How are flight prices from Knoxville to Des Moines looking right now?

    One-way fares from Knoxville to Des Moines are currently higher than usual. Average one-way flight prices are about $320, which is 25% above the typical average for this route.

  • How much time can I save by choosing a different layover airport from Knoxville to Des Moines?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 27m, compared with 4h 36m via Chicago O'Hare Intl (ORD) and 4h 48m via Charlotte Douglas (CLT).

  • What is the time difference between Knoxville and Des Moines?

    Des Moines is 1 hour behind Knoxville (Central Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What car rental options are available at Des Moines Airport (DSM)?

    Des Moines Airport (DSM) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
    • Hertz
    • Payless
    • Budget
    • Alamo
    • Avis

  • How much should I expect to pay for a Knoxville to Des Moines flight?

    Round-trip flights from Knoxville to Des Moines range from $343 to $555, with an average of $404 over the past 12 months. Anything below $343 counts as a good deal.

Your guide to booking Knoxville to Des Moines flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Friday departure instead of Saturday. On this route, Friday flights average $347 - about $520 less than Saturday (60% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Knoxville to Des Moines trip for September. Fares historically average $317 round-trip in that month - typically $635 less than the most expensive month, which is March (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Des Moines Airport.
    - Days Inn & Suites by Wyndham Des Moines Airport
    - Holiday Inn Des Moines-Airport/Conf Center By IHG
    - Quality Inn & Suites Des Moines Airport

More options for your flight from Knoxville to Des Moines

Complete your trip to Des Moines with a hotel stay or car rental

Car rentals in Des Moines
Hotels in Des Moines
Vacations in Des Moines