$188 Find Cheap Flights from Des Moines to Mexico - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Mexico departing on 8/31. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from Des Moines to Mexico

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Cancún
Cancún1 stop$506
Mexico City
Mexico City1 stop$477
Guadalajara
Guadalajara1 stop$422
Puerto Vallarta
Puerto Vallarta1 stop$531
León
León1 stop$548
Monterrey
Monterrey1 stop$563
Morelia
Morelia1 stop$624
Mérida
Mérida2 stops$619
Veracruz
Veracruz1 stop$558
Cancún
Cancún1 stop$506
Mexico City
Mexico City1 stop$477
Guadalajara
Guadalajara1 stop$422
Puerto Vallarta
Puerto Vallarta1 stop$531
León
León1 stop$548
Monterrey
Monterrey1 stop$563
Morelia
Morelia1 stop$624
Mérida
Mérida2 stops$619
Veracruz
Veracruz1 stop$558

Book Cheap Des Moines to Mexico Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Mexico that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Mexico

Mon, Aug 31 - Sat, Sep 5
Multiple Airlines Logo
8:54 pm - 4:49 pm
DSM
-
GDL
20h 55m
1 stop
Multiple Airlines Logo
8:02 am - 7:57 pm
GDL
-
DSM
34h 55m
2 stops
$422Multiple Airlines
Fri, Sep 11 - Fri, Sep 18
Multiple Airlines Logo
8:30 pm - 5:30 pm
DSM
-
MEX
22h 00m
1 stop
Multiple Airlines Logo
11:05 am - 8:39 am
MEX
-
DSM
44h 34m
2 stops
$477Multiple Airlines
Sat, Sep 19 - Sat, Sep 26
American Airlines Logo
4:14 pm - 10:00 am
DSM
-
CUN
17h 46m
1 stop
American Airlines Logo
3:56 pm - 11:12 am
CUN
-
DSM
19h 16m
1 stop
$506American Airlines
Thu, Sep 10 - Thu, Sep 17
American Airlines Logo
6:30 am - 1:57 pm
DSM
-
CUN
7h 27m
1 stop
American Airlines Logo
11:00 am - 11:12 pm
CUN
-
DSM
12h 12m
1 stop
$506American Airlines
Sun, Oct 4 - Thu, Oct 8
United Airlines Logo
6:00 am - 12:02 pm
DSM
-
CUN
6h 02m
1 stop
United Airlines Logo
3:38 pm - 11:35 pm
CUN
-
DSM
7h 57m
1 stop
$517United Airlines
Wed, Sep 16 - Wed, Sep 23
United Airlines Logo
6:24 am - 1:10 pm
DSM
-
CUN
6h 46m
1 stop
United Airlines Logo
1:12 pm - 10:30 pm
CUN
-
DSM
9h 18m
1 stop
$517United Airlines
Mon, Oct 5 - Wed, Oct 7
Aeromexico Logo
11:31 am - 7:50 pm
DSM
-
CUN
8h 19m
1 stop
Aeromexico Logo
6:04 am - 10:33 pm
CUN
-
DSM
16h 29m
2 stops
$517Aeromexico
Mon, Oct 5 - Wed, Oct 7
Aeromexico Logo
11:31 am - 7:50 pm
DSM
-
CUN
8h 19m
1 stop
Aeromexico Logo
2:25 pm - 10:33 pm
CUN
-
DSM
8h 08m
1 stop
$517Aeromexico
Tue, Jan 26 - Tue, Feb 23
Southwest Logo
6:55 am - 7:45 pm
DSM
-
CUN
11h 50m
2 stops
Southwest Logo
9:40 am - 8:40 pm
CUN
-
DSM
12h 00m
2 stops
$521Southwest
Tue, Jan 19 - Tue, Jan 26
Southwest Logo
5:55 am - 3:25 pm
DSM
-
CUN
8h 30m
2 stops
Southwest Logo
9:40 am - 8:40 pm
CUN
-
DSM
12h 00m
2 stops
$521Southwest
Booking Insights

KAYAK's insights & trends for Des Moines to Mexico flights

Get data-powered insights and trends into flights from Des Moines to Mexico to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Des Moines to Mexico?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Des Moines to Mexico, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Des Moines to Mexico is September, when tickets cost $559 (return) on average. On the other hand, the most expensive months are December and July, when the average cost of round-trip tickets is $797 and $760 respectively.

How far in advance should I book a flight from Des Moines to Mexico?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Des Moines to Mexico, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Des Moines to Mexico, you should book around 4 weeks before departure, which saves you about 29% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 6 weeks before departure.

Good to know

Low season

September

Cheapest flight

$188
Best time to beat the crowds but there is an average 3% increase in price.
Most popular time to fly and prices are also 10% lower on average.
Flight from Des Moines to Guadalajara

FAQs - booking Mexico flights

  • How does KAYAK find such low prices on flights from Des Moines to Mexico?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Mexico.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Mexico?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Mexico is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Mexico?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Mexico with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Mexico?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Mexico up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from Des Moines to Mexico

 
Need help choosing which airline to fly with from Des Moines to Mexico? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4226 reviews
8.0Comfort
8.1Boarding
8.6Crew
7.0Food
7.5Entertainment
Airline reviews

Eveeyrime I fly they are begging for bags due to cabin overhead space. What they should so ia take the bags that are clearly too big to fit wheels first on their side. And those of us who give up the bag should really get their bags first. When boarding, nobody wants stupid jokes about how hot it is on board. Give us some cool air. Im usually sick from the heat by the time we take off.

6.0 GoodVera, Jul 2026
MCO - BNA
Read more Southwest reviews

Eveeyrime I fly they are begging for bags due to cabin overhead space. What they should so ia take the bags that are clearly too big to fit wheels first on their side. And those of us who give up the bag should really get their bags first. When boarding, nobody wants stupid jokes about how hot it is on board. Give us some cool air. Im usually sick from the heat by the time we take off.

No wifi, seems to be very common with Southwest currently. Everything else was normal.

Poor customer service, no accommodation for passengers when the flight was delayed over 5 hours.

Friendly crew kept coming by to make sure all was ok, provide additional refreshments, etc.

It was good. Last flight was delayed but I always say that is in God's plan

Red eye from San Diego. Temperature of the cabin was way too warm and the air duct flowed very little air.

Overall good, just screaming kids in the area the whole flight.

My experience will Southwest was good. I wish there was more entertainment and the boarding process was slow at time but other than that my experience was great definitely will be flying with SouthWest again.

Flight was delayed by 2 hours, meaning that a flight to Dwnver which should have arrived at 11pm came into the airport at 1 am. Made for a very long day.

I think Southwest is the number one airline that anyone can fly I have flown for the first time Frontier and what a joke and their customer service United was a very strange experience I'm only sticking to Southwest from here on out for sure

My son’s suitcase was left behind at SFO and did not make the flight.

I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.

With Aeromexico it ended up good but with Delta it was bad because we did everything through Delta... Showed up at the Delta terminal... It was the wrong place! Nothing ever told us to go to the Aeromexico terminal. It said "in partnership with Aeromexico" but I was never instructed to check in with them or go to their terminal. We had to haul @$$ running through the airport and almost didn't make it thanks to this poor communication. 👎🏽

Excellent!!! Aeromexico is a great airline. What was not that good is the service provided by Kayak. It is never clear and not easy to manage.

It was nt delta. It was aeromexo. Service was awful. They served a very small drink and NO snack for a 3hr and 35min flight. Then for the first 30 min of the flight is was talk and talk over head interruption the movie/ show i picked to watch.

The flight was comfortable and uneventful, which is what I desire

It was an overnight flight and I desperately needed coffee before we landed, but Delta does only one beverage service, and that is shortly after takeoff, not before landing at 5 am.

Free Wi-Fi is good. That’s all - food mediocre, unfriendly crew, poor communication after trying to file a claim for my lost bag, which Delta didn’t even know was lost until I told them.

Typical flying experience in the US. Nothing particularly good or bad.

Everything went smoothly. I didn’t like that when I booked in the main cabin my wife and I weren’t seated together. One would think when booking on an option that allows picking your seat. They would put you and your travel partner together. Had to call to get it sorted. They did fix.

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

I needed internet for critical matters and it never worked.

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

No seat back entertainment. And app had a hard time getting entertainment loaded.

It was great with United overall except for two things. 1) It was a 5-hour flight and we were with kids, so we were asking for extra snacks. They were extremely reticent to dole them out even though there wasn't any meal and the kids were starting to hit their limit towards the end. 2) Baggage didn't arrive until 80 minutes after we landed.

Seats had less pitch than a regional jet. Food was OK. Have to buy alcohol on US based carriers flying international. Boarding was a mess. Did not have bags but overhead space was gone quick. Would like to see the airlines enforce the one bag over and one bag under policy

Great smooth flight. Had a seating change, but that was an improvement. Thanks United Airways Crew.

Very rough getting into denver. my kid threw up it was so rough.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.

At my original departure Istanbul I was told my seat and flight was cancelled from the 3rd party. I had no seat to get to my other flights .. they charged me $481 USD to board the flight that I already paid for

All went very well. We used the AIFI Airport, such a lovely facility. Definitely needs better transportation options to get there.

From the check-in, to the flight, and arriving, everything went very smoothly. Unfortunately, when I received my baggage it was severely damaged. I have a hard shelled suitcase and it was completely smashed it. I’m not sure how this could happened but I am extremely disappointed that my belongings were damaged beyond repair and continued use.

Lousy No wheelchair. As normal at Atlanta Cheap airline Cheap aero plane. - Neither entertainment nor food on a 5 hour saga

The plane was so outdated, that it made it uncomfortable. The temperature was hot during the whole flight

Some entertainment and food/snack service would have been nice

All the pessengers should be wait in a line útil the creo and piloto are arrived.

Planes seat could be bigger very uncomfortable for tall humans.

1 hour waiting for suitcases to come out traveling in business class and food in business class is a sandwich? Avoid Aeromexico .

No space reserved for anyone who didn’t have underseat in front of them. Made it inconvenient to get the backs secured. No inflight entertainment in the 190. Bring your own! Food was excellent and we were surprised to get a full breakfast.

Broke my luggage and I can't get a resolution yet.

The plane was experiencing problems with the HVAC system, it was very cold in the front of the plane and very hot in the back.

There were no TV screens - even in Business class. 5 delays, and only given $12 meal voucher! Terrible!

The professionals have excellent customer service, the seats don´t have enough space.

The boarding process needs to be fixed. The zone don't work, especially when there is hardly anyone in zones 3, 4,and 5, leaving the majority of the passengers backed up in the aisle, especially because passengers seated near the front are blocking passengers who are seated in the rear of the plane. It would also help if the size of carry on bags was more strictly enforced.

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

Delayed, missed connecting flight, ground crew double charged for international charges, were super rude and told me to just”deal with it” when I complained. Horrible airline, very frustrating.

Everything you need to know for your flight from Des Moines to Mexico

Information on your arrival and departure airports