$194 Find Cheap Flights from Des Moines to Mexico - Compare and Save

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Cheap Flights from Des Moines to Mexico

Cheapest round-trip prices found by our users on KAYAK in the last 5 days
Cancún
Cancún1 stop$592
Guadalajara
Guadalajara1 stop$480
Puerto Vallarta
Puerto Vallarta1 stop$646
León
León2 stops$675
Monterrey
Monterrey2 stops$649
Morelia
Morelia1 stop$676
Mérida
Mérida1 stop$660
Cancún
Cancún1 stop$592
Guadalajara
Guadalajara1 stop$480
Puerto Vallarta
Puerto Vallarta1 stop$646
León
León2 stops$675
Monterrey
Monterrey2 stops$649
Morelia
Morelia1 stop$676
Mérida
Mérida1 stop$660
Booking Insights

Price, demand and travel trends for Des Moines to Mexico flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

Are flights from Des Moines to Mexico cheaper or more expensive than last year?

Fares from Des Moines to Mexico are running about 6% higher than they were around this time last year, averaging $664 round-trip.

What are the cheapest fares from Des Moines to Mexico right now?

Here are the cheapest round-trip fares from Des Moines to Mexico on KAYAK in the last week:

• Mexico City Benito Juarez (MEX) from $438
• Guadalajara Miguel Hidal (GDL) from $480
• Cancun (CUN) from $592
• Cozumel Intl (CZM) from $613
• San José del Cabo Los Cabos (SJD) from $617

What’s the cheapest month to fly from Des Moines to Mexico?

January is the cheapest time of year to fly, with average fares of $600. Prices are highest in December, when average flight costs increase to around $805.

When is the best time to book flights from Des Moines to Mexico?

Book your flights 25 weeks before your trip. KAYAK data collected over the past 12 months shows that booking in this window can save you around 27% compared to booking last-minute (within 2 weeks of departure).

Which airport in Mexico is the cheapest to fly to from Des Moines?

Based on KAYAK data from the past 12 months, the cheapest airports to fly into Mexico are:

• Tulum Intl (TQO) (avg. price $555)
• Cozumel Intl (CZM) (avg. price $588)
• Cancun (CUN) (avg. price $653)

What’s the cheapest day to fly from Des Moines to Mexico?

Thursday tends to be the cheapest day to fly from Des Moines to Mexico, while Tuesday is the most expensive. Fares run about 13% higher that day, based on the past 12 months of KAYAK data.

What's the cheapest time of day to fly from Des Moines to Mexico?

Data from the past 12 months shows it's cheapest to fly to Mexico during the night with average prices of $539. The evening is the most expensive time to fly, with average prices of $796.

Key details for Des Moines to Mexico flights

Low season

September

Cheapest flight

$194
Beat the crowds with an average 49% drop in travelers.
The most popular month to fly with an average 59% increase in travelers.
One-way flight from Des Moines to Guadalajara

Your Des Moines to Mexico flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • Is now a good time to book a flight from Des Moines to Mexico?

    Yes. Fares from Des Moines to Mexico are low right now. As a rule of thumb, a round-trip under $597 (cheaper than most fares this year) is a good deal, so if you spot one at or below that, it's a good time to book.

  • How much should I budget for a flight from Des Moines to Mexico?

    Over the past 12 months, round-trip fares from Des Moines to Mexico have ranged from $597 to $855.

  • What are the main airports serving Mexico?

    Mexico has 62 airports. The three busiest are Cancun (CUN) (31% of arrivals), San José del Cabo Los Cabos (SJD) (14%) and Mexico City Benito Juarez (MEX) (12%).

  • What airlines fly nonstop from Des Moines to Mexico?

    Based on the flight schedule for the next 3 months, no airline regularly operates nonstop flights from Des Moines to Mexico. One-stop options include:

    • American Airlines
    • United Airlines
    • Delta

  • Which cabin classes are available on flights from Des Moines to Mexico?

    On flights from Des Moines to Mexico you can book Economy Class, Premium Economy Class, Business Class or First Class.

  • What are some popular landmarks in Mexico?

    KAYAK travelers' favorite landmarks in Mexico include:

    • El Ángel de la Independencia
    • Plaza de la Constitucion
    • Mexico City Stadium
    • Centro Cultural Tijuana

Your guide to booking Des Moines to Mexico flights

Get tips on when to book, when to fly and what to know before your trip.
  • If you can plan ahead, the sweet spot for booking your flight is 25 weeks before your trip. KAYAK data shows fares in this window are around 27% lower than last-minute bookings (made within 2 weeks of departure). Not ready to commit? Set a Price Alert and we'll let you know when prices change.
  • If your travel dates are flexible, book your trip for January when flights are typically cheapest and avoid December when prices are at their highest.
  • Flying on Thursday is usually the cheapest. Flights on Tuesday cost about 13% more on average, so being flexible with your travel dates could help you save.
  • If you're looking to save, Tulum Intl (TQO) is the cheapest airport to fly into from Des Moines. If you have onward travel, don't forget to factor in the cost of your journey by train, bus or domestic flight.
  • Start your trip in Cancún, which is the most popular destination in Mexico. From there, it's easy to continue on to other popular destinations such as Playa del Carmen, Cabo San Lucas and Puerto Vallarta.

Reviews of the top 5 airlines serving from Des Moines to Mexico

 
Need help choosing which airline to fly with from Des Moines to Mexico? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4219 reviews
8.1Boarding
8.6Crew
8.0Comfort
7.0Food
7.4Entertainment
Airline reviews

On time departure and arrival. Had to be the oldest plane in the SWA fleet but it got me where I needed to be.

8.0 ExcellentJohn, Oct 2026
Read more Southwest reviews

On time departure and arrival. Had to be the oldest plane in the SWA fleet but it got me where I needed to be.

Flight was delayed out of BWI unexpectedly / without a reason given but otherwise ok.

I got a bit sick on the flight, and was so grateful when the male flight attendant explained to me they keep the back row open for cases like mine. He took such great care of me! I was incredibly grateful.

Friendly crew. Snacks were carb-heavy. Flight was quite delaye

The service was fine, about the same as you get on most lower end airlines. I dont understand the perks of flying them much anymore for the cost.

the flight was significantly delayed. Not much was done by the airline to compensate passengers

the flight itself was totally fine. The crew were great and very helpful. The flight was delayed, however, over an hour without a lot of information as to why.

Had to walk back and forth between concourses to figure out which gate I was supposed to be at. The app and the flight board in the airport had different gates listed. Was told numerous times to check bags only to get on the plane and find that there was plenty of room for bags. The flight was over an hour late which had me landing after the last train departed. WiFi was unusable

My experience was okay I changed my returning flight and I was charged extra money which I dont think should be the case, especially because I experienced small delays from my going flight. And many flights were either canceled or delayed after my original flight time. I believe some customers should have the ability to change flights due to certain situations

I've taken four flights with Southwest within the last three months and every single flight was delayed.

Everything was pretty good. I would like to have more drinks (water) during four hours of the flight.

My son’s suitcase was left behind at SFO and did not make the flight.

I am writing to express my dissatisfaction with the poor service and unprofessional staff we encountered when traveling with an infant. Our flight was delayed, and the gate staff failed to manage the boarding process appropriately. Due to incorrect, unavailable, or missing 'pink tag' stroller and car seat check-in procedures at the gate, we were forced to board last. Furthermore, the gate staff was rude and dismissive, causing significant distress to our infant. To make matters worse, one of our checked items—an infant sleeper/lounger—was returned to us broken. Given the unsafe handling of essential equipment and unprofessional treatment, I expect a prompt resolution regarding compensation for the damaged items.

With Aeromexico it ended up good but with Delta it was bad because we did everything through Delta... Showed up at the Delta terminal... It was the wrong place! Nothing ever told us to go to the Aeromexico terminal. It said "in partnership with Aeromexico" but I was never instructed to check in with them or go to their terminal. We had to haul @$$ running through the airport and almost didn't make it thanks to this poor communication. 👎🏽

Excellent!!! Aeromexico is a great airline. What was not that good is the service provided by Kayak. It is never clear and not easy to manage.

It was nt delta. It was aeromexo. Service was awful. They served a very small drink and NO snack for a 3hr and 35min flight. Then for the first 30 min of the flight is was talk and talk over head interruption the movie/ show i picked to watch.

The flight was comfortable and uneventful, which is what I desire

It was an overnight flight and I desperately needed coffee before we landed, but Delta does only one beverage service, and that is shortly after takeoff, not before landing at 5 am.

Free Wi-Fi is good. That’s all - food mediocre, unfriendly crew, poor communication after trying to file a claim for my lost bag, which Delta didn’t even know was lost until I told them.

Typical flying experience in the US. Nothing particularly good or bad.

At my original departure Istanbul I was told my seat and flight was cancelled from the 3rd party. I had no seat to get to my other flights .. they charged me $481 USD to board the flight that I already paid for

All went very well. We used the AIFI Airport, such a lovely facility. Definitely needs better transportation options to get there.

From the check-in, to the flight, and arriving, everything went very smoothly. Unfortunately, when I received my baggage it was severely damaged. I have a hard shelled suitcase and it was completely smashed it. I’m not sure how this could happened but I am extremely disappointed that my belongings were damaged beyond repair and continued use.

Lousy No wheelchair. As normal at Atlanta Cheap airline Cheap aero plane. - Neither entertainment nor food on a 5 hour saga

The plane was so outdated, that it made it uncomfortable. The temperature was hot during the whole flight

Some entertainment and food/snack service would have been nice

All the pessengers should be wait in a line útil the creo and piloto are arrived.

Planes seat could be bigger very uncomfortable for tall humans.

1 hour waiting for suitcases to come out traveling in business class and food in business class is a sandwich? Avoid Aeromexico .

No space reserved for anyone who didn’t have underseat in front of them. Made it inconvenient to get the backs secured. No inflight entertainment in the 190. Bring your own! Food was excellent and we were surprised to get a full breakfast.

Miss My connection I had to take a flight from Indianapolis to Denver , then to san fransisco , sleep in sans fransisco en the flight to Los Cabos the next morning

The air hostess was excellent. I have taken so many flight domestic and international, this is the first time the air hostess was so caring. She was a delight

It was partially ok .. not anything like from Orlando to Houston... first the flight attendant was not so nice and insisted on have a small backpack down when really was not to put in danger anyone, also the beverages they were not so good... not big chance to select other tea.. the seat was partially ok could not have those flips to hold your head.. and finally when it land off in Guadalajara, it was raining and the flight was going to the main area then go back and drop us out of nowhere with the rain.

1 flight cancelled Had to fly out of different city Flight at new departure city was delayed 3 hours causing us to miss connecting flights. By the time we did make it to Prague our luggage did not. Had to wait day and a half for luggage to be delivered. Customer service was not good. Agents did not arrive at gate until 5-10 minutes before boarding

I needed internet for critical matters and it never worked.

It was better than excellent. The staff in Mason City were great. The young woman that pushed my wheelchair did more than could be expected of her. She came from India 17 years ago. I don't remember her name.

No seat back entertainment. And app had a hard time getting entertainment loaded.

Very rough getting into denver. my kid threw up it was so rough.

Liked that we left on time for each flight. Snacks not the best, but we're okay.

I had requested wheelchair assistance prior to flight. The airport staff had no record of it. It was not provided at Cedar Rapids which was a small airport, so I managed on my own. At O'Hare airport the same thing happened. The staff told me they had no record of my request for a wheel chair. But they finally provided it after a delay when I insisted that I needed it.

Flight was delayed a couple of times. Which is annoying, but manageable.

Delayed couple hours due to airplane maintenance issues, we boarded and then asked to unboard, but cmon!! Can they do the whole maintenance prior to boarding?

Broke my luggage and I can't get a resolution yet.

The plane was experiencing problems with the HVAC system, it was very cold in the front of the plane and very hot in the back.

The boarding process needs to be fixed. The zone don't work, especially when there is hardly anyone in zones 3, 4,and 5, leaving the majority of the passengers backed up in the aisle, especially because passengers seated near the front are blocking passengers who are seated in the rear of the plane. It would also help if the size of carry on bags was more strictly enforced.

In flight connectivity (via T-Mobile) was often not working.

Terrible. Internet/kiosk glitch prevented baggage checkin. Line at ticket co in Ter was under serviced and did not move. Agents did not call for flight but rather allowed time to pass. Then told each person as they reached the front if line that it was too late to check bags so they’d have to rebook flights. At least 15 people missed the flight as a result of this incompetence.

It was exactly what I expected, actually arriving sooner than scheduled.

Terrible, they canceled my flight due to an issue they had, couldn't fly me into the same place within 24 hrs so had to fly in 2.5 hrs away from my destination and spend even more money. The customer service was terrible (except at the airport in Charleston). Had to call to get my checked baggage fees reimbursed 2 wks later in which one customer service agent was very rude, wouldn't listen and then hung up on me. The second lady I spoke with was actually able to help me with that part thankfully. Would not recommend flying AA.

Delayed, missed connecting flight, ground crew double charged for international charges, were super rude and told me to just”deal with it” when I complained. Horrible airline, very frustrating.

More options for your flight from Des Moines to Mexico

Complete your trip to Mexico with a hotel stay or car rental