$136 Find Cheap Flights from Des Moines to Mississippi

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Mississippi departing on 4/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Mississippi

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Mississippi, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Mississippi, as well as popular online travel agencies
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Cheap Flights from Des Moines to Mississippi

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Jackson
Jackson1 stop$342
Gulfport
Gulfport1 stop$289
Memphis
Memphis1 stop$251
Jackson
Jackson1 stop$342
Gulfport
Gulfport1 stop$289
Memphis
Memphis1 stop$251

Book Cheap Des Moines to Mississippi Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Mississippi that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Mississippi

Sat, Apr 18 - Sat, Apr 25
Southwest Logo
5:35 am - 11:40 am
DSM
-
MEM
6h 05m
1 stop
Southwest Logo
5:00 am - 11:30 am
MEM
-
DSM
6h 30m
1 stop
$251Southwest
Sat, Apr 18 - Sat, Apr 25
Southwest Logo
5:35 am - 2:00 pm
DSM
-
MEM
8h 25m
2 stops
Southwest Logo
5:00 am - 11:30 am
MEM
-
DSM
6h 30m
1 stop
$256Southwest
Sat, Apr 18 - Sat, Apr 25
Southwest Logo
5:35 am - 2:00 pm
DSM
-
MEM
8h 25m
2 stops
Southwest Logo
5:25 am - 1:30 pm
MEM
-
DSM
8h 05m
2 stops
$261Southwest
Sat, Apr 18 - Sat, Apr 25
Delta Logo
2:44 pm - 7:29 pm
DSM
-
MEM
4h 45m
1 stop
Delta Logo
6:20 am - 11:05 am
MEM
-
DSM
4h 45m
1 stop
$265Delta
Sat, Apr 18 - Sat, Apr 25
Southwest Logo
6:40 am - 2:00 pm
DSM
-
MEM
7h 20m
2 stops
Southwest Logo
5:00 am - 11:30 am
MEM
-
DSM
6h 30m
1 stop
$270Southwest
Tue, Apr 21 - Tue, Apr 28
American Airlines Logo
6:13 pm - 10:59 pm
DSM
-
MOB
4h 46m
1 stop
American Airlines Logo
5:22 am - 11:26 am
MOB
-
DSM
6h 04m
1 stop
$286American Airlines
Sat, May 23 - Sat, May 30
Delta Logo
5:27 am - 12:50 pm
DSM
-
BTR
7h 23m
1 stop
Delta Logo
4:00 pm - 10:32 pm
BTR
-
DSM
6h 32m
1 stop
$289Delta
Tue, Apr 21 - Tue, Apr 28
American Airlines Logo
6:13 pm - 10:59 pm
DSM
-
MOB
4h 46m
1 stop
American Airlines Logo
10:49 am - 8:21 pm
MOB
-
DSM
9h 32m
2 stops
$292American Airlines
Tue, Aug 11 - Sat, Aug 22
United Airlines Logo
6:00 am - 3:32 pm
DSM
-
BTR
9h 32m
2 stops
United Airlines Logo
7:15 am - 2:17 pm
BTR
-
DSM
7h 02m
1 stop
$294United Airlines
Tue, Aug 11 - Sat, Aug 22
United Airlines Logo
5:00 am - 1:15 pm
DSM
-
BTR
8h 15m
2 stops
United Airlines Logo
4:07 pm - 11:55 pm
BTR
-
DSM
7h 48m
2 stops
$300United Airlines
Booking Insights

KAYAK's insights & trends for Des Moines to Mississippi flights

Get data-powered insights and trends into flights from Des Moines to Mississippi to help you find the cheapest flights, the best time to fly and much more.

Which airlines provide the cheapest flights from Des Moines to Mississippi?

The cheapest round-trip price for the route for each airline clicked by KAYAK users in the last 72 hours.

In the past 3 days, the cheapest round-trip tickets from Des Moines to Mississippi were found on Southwest ($256) and Delta ($271).

Find deals

Good to know

Low seasonAugust
Cheapest flight$136
Best time to beat the crowds with an average 33% drop in price.
Most popular time to fly and prices are also 14% lower on average.
Flight from Des Moines to Memphis

FAQs - booking Mississippi flights

  • How does KAYAK find such low prices on flights from Des Moines to Mississippi?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Mississippi.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Mississippi?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Mississippi is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Mississippi?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Mississippi with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Mississippi?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Mississippi up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Des Moines to Mississippi

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Mississippi. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Mississippi? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.1
American AirlinesOverall score based on 11403 reviews
7.2Comfort
8.0Crew
6.9Entertainment
6.4Food
7.5Boarding
Airline reviews

Never had such a lazy first class attendant. Literally spent 60%+ of the flight playing games on her personal phone making up excuses of why she was unavailable.

2.0 MediocreCody, Mar 2026
ORF - CLT
Read more American Airlines reviews

Never had such a lazy first class attendant. Literally spent 60%+ of the flight playing games on her personal phone making up excuses of why she was unavailable.

The flight attendants and the service is getting worse by the day.

Not to have gotten delayed by 2+ hours for the fourth straight American flight. They're the worst.

Like all of the flights I took to get down to Dallas. They were delayed

Other than nearly three hour delay for maintenance issues, everything went smooth

Plane from partner PSA was filthy. Plastic needs to be thoroughly cleaned. Really disgusting to look at and wonder about cleanliness of parts less visible.

The baggage claim experience was poor. The plane crew and the AA app said that checked baggage in CLT would be at carousel 7 but the sign at Baggage Claim said carousel 1. The carousel 1 sign had the correct flight # listed above the belt. But the luggage never came. I went to an AA baggage claim office after about 1 hour and the clerk directed me to another AA room that was poorly marked, with a closed door and no obvious way to know what to do. Finally someone opened the door and my bag was inside. The clerk was totally unable to explain why.

They are rarely on time! Very hard to plan your travels when flights or connections keep getting delayed.

Flight delay for mechanical. Inbound arrived on time. No one said why mechanical delay.

Forced to check bags. Crew uninterested in collecting trash. Unclean seats.

Everything you need to know for your flight from Des Moines to Mississippi

Information on your arrival and departure airports

Des Moines (DSM)