$129 Find Cheap Flights from Des Moines to Mississippi

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Des Moines to Mississippi departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Mississippi

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Mississippi, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Des Moines to Mississippi, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Des Moines to Mississippi

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Jackson
Jackson1 stop$275
Gulfport
Gulfport1 stop$249
Memphis
Memphis1 stop$237
Jackson
Jackson1 stop$275
Gulfport
Gulfport1 stop$249
Memphis
Memphis1 stop$237

Book Cheap Des Moines to Mississippi Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Des Moines to Mississippi that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Des Moines to Mississippi

Tue, Sep 16 - Wed, Sep 17
Delta Logo
6:00 am - 1:22 pmDSM-MEM
7h 22m1 stop
Delta Logo
12:13 pm - 5:13 pmMEM-DSM
5h 00m1 stop
$237Delta
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Tue, Sep 16 - Thu, Sep 18
Delta Logo
2:05 pm - 8:47 pmDSM-MEM
6h 42m1 stop
Delta Logo
6:00 am - 10:14 amMEM-DSM
4h 14m1 stop
$241Delta
Find Deal
Tue, Sep 30 - Tue, Oct 7
American Airlines Logo
3:50 pm - 10:59 pmDSM-MEM
7h 09m2 stops
American Airlines Logo
5:52 pm - 11:59 pmMEM-DSM
6h 07m1 stop
$242American Airlines
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Thu, Dec 11 - Mon, Dec 15
American Airlines Logo
2:08 pm - 6:50 pmDSM-MEM
4h 42m1 stop
American Airlines Logo
6:08 pm - 10:42 pmMEM-DSM
4h 34m1 stop
$245American Airlines
Find Deal
Wed, Sep 17 - Wed, Sep 24
Southwest Logo
8:25 am - 7:40 pmDSM-MEM
11h 15m2 stops
Southwest Logo
10:55 am - 9:25 pmMEM-DSM
10h 30m1 stop
$253Southwest
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Tue, Sep 16 - Wed, Sep 17
Southwest Logo
8:25 am - 7:40 pmDSM-MEM
11h 15m2 stops
Southwest Logo
10:55 am - 9:25 pmMEM-DSM
10h 30m1 stop
$294Southwest
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Sun, Aug 31 - Thu, Sep 4
United Airlines Logo
8:00 am - 2:50 pmDSM-MEM
6h 50m1 stop
United Airlines Logo
7:30 am - 2:20 pmMEM-DSM
6h 50m1 stop
$297United Airlines
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Thu, Oct 16 - Sun, Oct 19
 Logo
10:41 am - 9:00 amDSM-MEM
22h 19m1 stop
 Logo
8:20 pm - 10:35 amMEM-DSM
14h 15m1 stop
Thu, Oct 16 - Sun, Oct 19
 Logo
10:41 am - 9:00 amDSM-MEM
22h 19m1 stop
 Logo
4:08 pm - 5:01 pmMEM-DSM
24h 53m2 stops
Mon, Sep 8 - Thu, Sep 11
United Airlines Logo
1:10 pm - 9:37 pmDSM-MEM
8h 27m2 stops
United Airlines Logo
7:30 am - 12:14 pmMEM-DSM
4h 44m1 stop
$351United Airlines
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Booking Insights

KAYAK's insights & trends for Des Moines to Mississippi flights

Get data-powered insights and trends into flights from Des Moines to Mississippi to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Des Moines to Mississippi?

The average price of all round-trip flights from Des Moines to Mississippi clicked on KAYAK for each day over the last 12 months.

When flying from Des Moines to Mississippi, you should consider leaving on a Saturday and avoid Wednesdays if you are looking for the best rates. For your return to Des Moines, you’ll find the best rates on Saturdays and the most expensive ones on Wednesdays.

Good to know

Low seasonMarch
Cheapest flight$129
Best time to beat the crowds but there is an average 60% increase in price.
Most popular time to fly and prices are also 4% lower on average.
Flight from Des Moines to Jackson

FAQs - booking Mississippi flights

  • How does KAYAK find such low prices on flights from Des Moines to Mississippi?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Des Moines to Mississippi.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Des Moines to Mississippi?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Des Moines to Mississippi is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Des Moines to Mississippi?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Des Moines to Mississippi with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Des Moines to Mississippi?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Des Moines to Mississippi up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to Mississippi?

    The cheapest time of day to fly to Mississippi is generally in the evening, when round-trip flights cost $296 on average. Morning departures are around 27% more expensive than evening flights, on average. The most expensive time of day to fly to Mississippi is generally in the afternoon, which is peak travel time and where the average cost of a ticket is $560.

Reviews of the top airline flying from Des Moines to Mississippi

 
See real verified KAYAK customer reviews for airlines flying from Des Moines to Mississippi. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Des Moines to Mississippi? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.2
American AirlinesOverall score based on 10000 reviews
8.0Crew
6.9Entertainment
7.2Comfort
6.5Food
7.5Boarding
Airline reviews

Any flight to ORD after about 2pm this summer has been challenging. Flight was delayed getting in (coming from ORD) and that led to it not leaving before a ground stop due to lightening before they could fuel the plane, and so forth. They made up some time but we were still late in arriving at ORD, and that led to missed connections.

6.0 GoodMitchell, Aug 2025CMH - ORD
Read more American Airlines reviews

Any flight to ORD after about 2pm this summer has been challenging. Flight was delayed getting in (coming from ORD) and that led to it not leaving before a ground stop due to lightening before they could fuel the plane, and so forth. They made up some time but we were still late in arriving at ORD, and that led to missed connections.

Food was ok, but not as good as I have had before on AA.

No issues. They did change our gate FOUR times in about 30 minutes which was mildly annoying but the flight was fine.

Great flight. No issues at all. I still think boarding could be more efficient but otherwise, a good experience.

Pretty good. The food was just mediocre, the boarding and crew were good.

The comfort of the seats was great, the crew eased my child’s anxieties and the fact that I had full cans of my beverage choice was great.

My flight got switched and my prepaid bag didnt transfer over properly so I paid to check ANOTHER BAG. I was placed in a middle seat and it was just miserable. At least it was a bulkhead row so I had legroom. The flight just never seem3d to end

4 hours late, including over +1 hour waiting in plane to take off. Baggage left behind too.

Sat on the ground in Cincinnati for 50 minutes before deplaning

While waiting to claim my checked luggage, I discovered the airline had lost it. After a long wait and inquiries, I discovered it was on another flight. Fortunately, the airline finally sent my luggage home.

Everything you need to know for your flight from Des Moines to Mississippi

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