SNA

$123 Find Cheap Flights from Florida Keys to John Wayne (Santa Ana) - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Santa Ana departing on 8/9. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Florida Keys to Santa Ana

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Florida Keys to Santa Ana that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Florida Keys to Santa Ana

Thu, Jul 30 - Tue, Aug 4
Frontier Logo
6:50 am - 5:54 pm
MIA
-
SNA
14h 04m
1 stop
Frontier Logo
4:13 pm - 6:30 am
SNA
-
MIA
11h 17m
1 stop
$244Frontier
Fri, Jul 31 - Wed, Aug 5
Frontier Logo
6:20 am - 2:47 pm
MIA
-
SNA
11h 27m
1 stop
Frontier Logo
4:13 pm - 6:30 am
SNA
-
MIA
11h 17m
1 stop
$245Frontier
Fri, Jul 31 - Fri, Aug 7
Frontier Logo
6:20 am - 2:47 pm
MIA
-
SNA
11h 27m
1 stop
Frontier Logo
7:53 pm - 6:30 am
SNA
-
MIA
7h 37m
1 stop
$246Frontier
Thu, Sep 10 - Mon, Sep 14
Multiple Airlines Logo
7:00 am - 6:18 pm
MIA
-
SNA
14h 18m
1 stop
Multiple Airlines Logo
7:13 pm - 5:13 pm
SNA
-
MIA
19h 00m
1 stop
$295Multiple Airlines
Thu, Oct 15 - Tue, Oct 20
Delta Logo
2:35 pm - 10:29 pm
EYW
-
SNA
10h 54m
1 stop
Delta Logo
6:45 am - 7:43 pm
SNA
-
EYW
9h 58m
1 stop
$531Delta
Thu, Oct 15 - Tue, Oct 20
Delta Logo
11:45 am - 10:24 pm
EYW
-
SNA
13h 39m
2 stops
Delta Logo
6:45 am - 7:43 pm
SNA
-
EYW
9h 58m
1 stop
$536Delta
Thu, Oct 15 - Tue, Oct 20
American Airlines Logo
2:57 pm - 8:07 pm
EYW
-
SNA
8h 10m
1 stop
American Airlines Logo
6:45 am - 6:24 pm
SNA
-
EYW
8h 39m
2 stops
$604American Airlines
Thu, Oct 15 - Tue, Oct 20
American Airlines Logo
12:06 pm - 9:51 pm
EYW
-
SNA
12h 45m
2 stops
American Airlines Logo
6:45 am - 6:24 pm
SNA
-
EYW
8h 39m
2 stops
$749American Airlines
Sun, Jul 5 - Thu, Jul 9
Multiple Airlines Logo
12:05 pm - 12:11 pm
EYW
-
SNA
27h 06m
2 stops
Multiple Airlines Logo
3:22 pm - 11:07 am
SNA
-
EYW
16h 45m
1 stop
$822Multiple Airlines
Thu, Oct 15 - Tue, Oct 20
Breeze Airways Logo
12:01 pm - 4:15 pm
EYW
-
SNA
31h 14m
3 stops
Breeze Airways Logo
7:30 am - 9:24 am
SNA
-
EYW
22h 54m
3 stops
$1,024Breeze Airways
Useful Info

Good to know

Low seasonJanuary
Cheapest flight$123
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly and prices are also 5% lower on average.
Flight from Miami to John Wayne (Santa Ana)

FAQs for booking flights from Florida Keys to John Wayne (Santa Ana)

  • How does KAYAK find such low prices on flights from Florida Keys to John Wayne (Santa Ana)?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Florida Keys to John Wayne (Santa Ana).

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Florida Keys to John Wayne (Santa Ana)?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to John Wayne (Santa Ana) from Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Florida Keys to John Wayne (Santa Ana)?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to John Wayne (Santa Ana) with an airline and back to Florida Keys with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Florida Keys to John Wayne (Santa Ana)?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to John Wayne (Santa Ana) from Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Florida Keys to Santa Ana

 
Need help choosing which airline to fly with from Florida Keys to Santa Ana? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.4
United AirlinesOverall score based on 9875 reviews
8.1Crew
7.1Entertainment
7.3Comfort
7.7Boarding
6.6Food
Airline reviews

This was an overnight flight, and in the morning they did know coffee service. How you can throw passengers in a San Francisco airport at 5:40 a.m. in the morning and not giving them Coffee is a crime.

8.0 ExcellentWilliam Drew, Jun 2026
HNL - SFO
Read more United Airlines reviews

This was an overnight flight, and in the morning they did know coffee service. How you can throw passengers in a San Francisco airport at 5:40 a.m. in the morning and not giving them Coffee is a crime.

Our flight was delayed several Times due to mechanical issues. Although I understand this may happen at times, it was very inconvenient and we had to book a hotel for an overnight stay. We were traveling with my 3-yo grandson and waiting at the airport from noon until 6:30pm with no reassurance that our next rescheduled flight would depart, we had to decide what’s best for him. A day later, I found out that I may be able to demand compensation if my flight is delayed more than 4 hours. I will hav to read the fine print next time.

Service was professional and quick. Premium economy seat was comfortable given the class

Like: departed and arrived on time. Unlike: Food options for purchase allways bad, 1 of 2 of the crew members not very friendly at all. Seats and leg room aweful. At this point I am thinking on switching to AA.

The staff was extremely helpful and friendly at all times! They went above and beyond to get us into an earlier flight in San Diego to make our connection in SFO possible, because our original flight did actually not make it! I did so much appreciate the UA team and how they made this possible. We also didn’t have seats together on the long flight to Singapore, but they found us seats together last moment with no additional cost! Nobody sat next to us, so that we were able to sleep! Thanks to UA for improving their service and Underpricer for booking this trip! Please be careful: 1,5 hrs for transfer in San Francisco might not be enough time in the future

Packed flight, which makes it tough on crew and boarding staff (and the customers of course). But this was great boarding, clear instructions, etc. Traveling on the weekends are always fraught with danger as you have families and less frequent flyers thus more confusion. But this flight went as planned.

Destroyed my suitcase. Tired of talking about it. Cancelling my unite mileage plus account.

New plane was lovely. Crew customer service is always lax but expected. Kraft on time and arrived safely.

Seat pitch is horrible especially on the 15 hour flight. Gate crew at SFO was Outstanding. The flight crew was also great.

6 1/2 hours from Tampa to SFO on a Boeing 737. Cramped. No Service. No real food. One pass for coffee at the beginning and a second pass THREE hours later. And check-in in Tampa was nasty even by United standards. And I am at almost TWO million miles on United. It's a non-stop. But terrible service.

Flight cancelled. Twice. And no communication. No gate agent. Went past boarding time and had to go and see email from AA. Airport communication was bad

It was so much better than expected, Ohare is not such a pleasant experience but American Airlines with the new, clean aeroplane and free Wi-Fi was outstanding and the crew so pleasant and helpful.

Was put into a seat right behind the toilet that had no entertainment possible but did have plenty of leg room over noisy part of plane.

American delayed the flight for a crew rest period. The delay occurred late in the evening - the earliest i can find is 10:20 pm. With a 6 am flight anyone on the flight would have already have been asleep (unless you are insane, a vampire or on drugs) and at least for me i was already on the way to the airport at 445 am the next morning when i discovered they delayed the flight until 9 am. Given the incoming flight was in the air at 6 pm the evening before this should have been figured out a lot more timely that was there only crew to use. Just frustrating given there is no consideration for customer experience anymore in flying.

Flight: Started on time. Comfortable flight. Arrived on time. Crew: Very cordial and helpful. Drinks and snack was served with a smile. Overall enjoyed the trip. Regards, Hari Doss Chanchala Doss

To have arrived on time and not 3 hours late after having already spent $100 to change to an earlier flight, only to arrive back home close to the original flight time.

American Airlines is a miserable experience. It is predictably miserable, in the sense that every time I fly American, I brace myself for the certainty that it will be unpleasant and uncomfortable. But it is unpredictable in the sense that I never know if the flight will be on time or delayed nine hours (both happened to me this week). I never know if I will be able to sit in the seat that I selected when I purchased the ticket or if I will be told by Customer Service (!!!) that I must relocate from first class to a seat in the back of the aircraft with no explanation (both happened to me this week). Will the food be frozen and half defrosted, or scalding hot? Will the drinks be warm? Will the flight attendants be surly and mean? Will the toilets be cramped and foul? Will the seats be narrow and uncomfortable? Will there be a real electric outlet at the seat, or just an unreliable USB-2 port? Will there be enough seats in the boarding lounge or just a few? Will the boarding process be smooth and efficient, or will the gate agents mess it up and delay it needlessly for 30 or 40 minutes? Will the catering and cleaning crew be prompt or will they take an extra 30 minutes? Will the brakes on the aircraft work properly, or will the pilot delay takeoff for four hours while the ground crew attends to what can only be described as routine maintenance that should have been done the night before? I've eexperienced every one of these unpleasant things this year, 2026. The only thing I can reliably count on is that American will find a new way to make the experience of flying as miserable as they possibly can.

Wifi was spotty. Tray table was very dirty when I sat down.

The WiFi would not connect enough for me to do my actual work. It permaspooled, disconnected, said it was connected, then wouldn't open an email... it was frustrating. I am not a tall person, 5'4" - and I felt cramped with little room to reach into my bag under the seat in front of me. I feel sorry for anyone taller than me having to fly. the one positive thing I will add, is the overhead bins are roomy enough to manage more bags than other carriers.

Going non stop to lax like I paid for. Not stopping in MCI for gas. Too long of delays

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