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$116 Find Cheap Flights from Florida Keys to John Wayne (Santa Ana) - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight to Santa Ana departing on 9/17. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Cheap Flights from Florida Keys to Santa Ana

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Florida Keys to Santa Ana that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Florida Keys to Santa Ana

Thu, Sep 3 - Thu, Sep 10
Frontier Logo
6:50 am - 5:54 pm-
14h 04m
Frontier Logo
11:50 am - 12:46 am-
9h 56m
$234Frontier
Thu, Sep 17 - Mon, Sep 21
Frontier Logo
5:50 am - 11:05 am-
8h 15m
Frontier Logo
10:45 am - 10:17 pm-
8h 32m
$234Frontier
Thu, Sep 24 - Mon, Sep 28
Frontier Logo
5:50 am - 11:05 am-
8h 15m
Frontier Logo
10:45 am - 10:00 pm-
8h 15m
$234Frontier
Thu, Jan 14 - Mon, Jan 18
American Airlines Logo
7:00 am - 11:48 am-
7h 48m
American Airlines Logo
1:24 pm - 10:33 pm-
6h 09m
$333American Airlines
Mon, Aug 31 - Wed, Sep 9
American Airlines Logo
12:15 pm - 7:35 pm-
10h 20m
American Airlines Logo
10:35 am - 11:18 pm-
9h 43m
$333American Airlines
Tue, Sep 15 - Wed, Sep 23
United Airlines Logo
12:17 pm - 6:51 pm-
9h 34m
United Airlines Logo
11:10 am - 9:58 pm-
7h 48m
$333United Airlines
Tue, Oct 27 - Fri, Oct 30
United Airlines Logo
4:58 pm - 9:55 pm-
7h 57m
United Airlines Logo
6:36 pm - 7:50 am-
10h 14m
$333United Airlines
Thu, Sep 3 - Sun, Sep 6
Delta Logo
2:08 pm - 6:37 pm-
7h 29m
Delta Logo
2:00 pm - 12:47 am-
7h 47m
$333Delta
Wed, Sep 2 - Fri, Sep 11
Delta Logo
7:00 am - 12:46 pm-
8h 46m
Delta Logo
4:58 pm - 5:49 am-
9h 51m
$333Delta
Fri, Sep 11 - Sat, Sep 12
Delta Logo
2:45 pm - 8:23 pm-
8h 38m
Delta Logo
6:45 am - 7:05 pm-
9h 20m
$333Delta
Useful Info

Good to know

Low season

January

Cheapest flight

$116
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly with an average 5% increase in price.
Flight from Miami to John Wayne (Santa Ana)

FAQs for booking flights from Florida Keys to John Wayne (Santa Ana)

  • How does KAYAK find such low prices on flights from Florida Keys to John Wayne (Santa Ana)?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Florida Keys to John Wayne (Santa Ana).

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Florida Keys to John Wayne (Santa Ana)?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to John Wayne (Santa Ana) from Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Florida Keys to John Wayne (Santa Ana)?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to John Wayne (Santa Ana) with an airline and back to Florida Keys with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Florida Keys to John Wayne (Santa Ana)?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to John Wayne (Santa Ana) from Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Florida Keys to Santa Ana

 
Need help choosing which airline to fly with from Florida Keys to Santa Ana? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8491 reviews
8.1Boarding
8.5Crew
7.8Entertainment
7.8Comfort
7.2Food
Airline reviews

Comfortable seats. Nice service online. Short flight, so not a lot of time to enjoy.

8.0 ExcellentMichael, Jul 2026
Read more Delta reviews

Comfortable seats. Nice service online. Short flight, so not a lot of time to enjoy.

The flight was done by SkyWest only WIFI no entertainment center are available on the CRJ

Delta is always late. Ruined our first day of a short vacation. Timing is important. We pay to stay on an itinerary

We never made it on this flight because we missed our connection due to o delayed flight from Jackson.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

Great. Flight departed early and arrived early. Deplaning and baggage claim ww were quick.

They separated our seats and moved us to the back of the plane. Hundreds of dollars and thousands of miles used and this was my platinum member experience.

The flight was canceled two hours before departure, it took over five hours to rebook us on another flight.

Worst service and meal in Delta First Class ever. I am really surprised as a loyal Delta flier. There was no welcoming or warmth from the crew toward us or our fellow travelers in the First Class cabin of the Airbus 321 Neo plane.

There was a piece of plastic baked into my buttermilk biscuit! I have a pictures. The flight attendants in first class were really apologetic, and tried to rectify the situation. I I am very appreciative that they were able to give me some packets of pretzels and gummy bears. I understand they don't personally handle the food until warming it up so I know it wasn't their fault. I don't know whether it was a newer aircraft, or different food packaging, but I was happy that when the food was being warmed up - it didn't smell like plastic. Jokes on me with finding plastic in my food.

Destroyed my suitcase. Tired of talking about it. Cancelling my unite mileage plus account.

6 1/2 hours from Tampa to SFO on a Boeing 737. Cramped. No Service. No real food. One pass for coffee at the beginning and a second pass THREE hours later. And check-in in Tampa was nasty even by United standards. And I am at almost TWO million miles on United. It's a non-stop. But terrible service.

The crew was great. Very friendly and responsive. The plane was old, small and tight. We ran out of overhead space and I had to check. Middle seat was particularly tight.

Flight delayed for more than 16 hrs and no effort was spent to provide an alternate

My flight was delayed a very short period of time but they did not hold my connecting flight to San Diego, also through United. So they closed the doors before we got off our plane. They would only have to help the door open for another five to ten minutes. So I missed a court deadline for a manditory mediation settlement conference for my client. I had to get an associate to be there in person and be on the phone with him relaying what he needs to do the entire time. The court was very upset with me and so was my client. United cannot be trusted.

Awful. Worst airline I have ever been on. Crew were among the rudest people I have ever dealt with. United staff members were rude and disrespectful. My flight was delayed, causing me to miss a connecting flight. I understand things happen, but when staff start lying about what actually happened, that is when I have an issue. Just be honest, really it isn’t that hard. I’m being very honest with this review and I don’t find this difficult what so ever. In fact, because of United Airlines, my Christmas holiday was off to a really rocky start. As someone who has traveled across the world, it has only been United that I have had a truly awful experience.

The control panel for the seat back screen did not work at all after takeoff.

The crew was nice but the people going to Orange County are so entitled. Everyone thinks everything is suppose for be perfect for them. Tough crowd.

How they treated my luggage was horrible. And foods are not edible… Flight attendants were not listening my request. Etc

Worst communication. Delayed boarding for two hours without a single announcement until hour 1 had passed - on time status showing until our flight was supposed to takeoff and the crew had already walked away. No one was boarding. Disgusting part of DFW overcrowded with no AC on a 97 degree day. Then the first app update is that we’d take off in 15 mins… but again no one had boarded a full flight. No announcement in the terminal so everyone is just crowded around a disgusting place with no info for over an hour which turned into two. This was an overfill flight and a disgrace to passenger decency all while likely just trying to fix their own issue of overbooking. The worst airline at the worst airport.

Flight: Started on time. Comfortable flight. Arrived on time. Crew: Very cordial and helpful. Drinks and snack was served with a smile. Overall enjoyed the trip. Regards, Hari Doss Chanchala Doss

To have arrived on time and not 3 hours late after having already spent $100 to change to an earlier flight, only to arrive back home close to the original flight time.

The WiFi would not connect enough for me to do my actual work. It permaspooled, disconnected, said it was connected, then wouldn't open an email... it was frustrating. I am not a tall person, 5'4" - and I felt cramped with little room to reach into my bag under the seat in front of me. I feel sorry for anyone taller than me having to fly. the one positive thing I will add, is the overhead bins are roomy enough to manage more bags than other carriers.

A first class seat should fit a fat person, and this doesn't. The trays in the armrest are less functional than an ordinary tray in the back of the seat.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

Amazing food, great staff, with one noticable detail missing ...but no seat entertainment in any of aircraft ...I am not a fan

Plane felt so crowded and tightly packed. The chair itself was not comfortable.

2.5h delay due to unruly passenger in first class. Had to be removed from the flight. No food unless pre ordered. Didn't know we would need it because of delay.

On our return trip we were able to get on an earlier flight. American airlines made it so easy to do & at no cost!

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