$116 Find Cheap Flights from John Wayne (Santa Ana) to Florida Keys - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Florida Keys departing on 9/13. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

Save 21% or more on flights. Compare deals from all over the web.

Never overpay with our price tracking tools.

Filter searches by price, airline and more to find your best flights.

Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Ana to Florida Keys

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Miami
Miami1 stop$234
Key West
Key West1 stop$497
Miami
Miami1 stop$234
Key West
Key West1 stop$497

Book Cheap Santa Ana to Florida Keys Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Florida Keys that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Florida Keys

Thu, Sep 10 - Thu, Sep 17
Frontier Logo
11:50 am - 12:46 amSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
9h 56m1 stop Denver Intl
Frontier Logo
5:50 am - 11:05 amMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
8h 15m1 stop Denver Intl
$234Frontier
Thu, Sep 10 - Mon, Sep 14
Frontier Logo
11:50 am - 12:46 amSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
9h 56m1 stop Denver Intl
Frontier Logo
5:50 am - 11:05 amMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
8h 15m1 stop Denver Intl
$234Frontier
Tue, Sep 15 - Mon, Sep 21
Multiple Airlines Logo
10:36 am - 5:13 pmSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
27h 37m1 stop Seattle/Tacoma Intl
Multiple Airlines Logo
5:50 am - 11:05 amMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
8h 15m1 stop Denver Intl
$289Multiple Airlines
Sat, Oct 24 - Fri, Oct 30
American Airlines Logo
12:41 pm - 10:42 pmSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
7h 01m1 stop Phoenix Sky Harbor Intl
American Airlines Logo
4:45 pm - 10:29 pmMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
8h 44m1 stop Dallas/Fort Worth
$333American Airlines
Thu, Nov 19 - Wed, Nov 25
American Airlines Logo
12:10 pm - 11:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
8h 49m1 stop Dallas/Fort Worth
American Airlines Logo
7:00 am - 12:26 pmMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
8h 26m1 stop Dallas/Fort Worth
$333American Airlines
Thu, Sep 24 - Tue, Sep 29
United Airlines Logo
7:30 am - 8:58 pmSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
10h 28m1 stop San Francisco
United Airlines Logo
8:02 am - 1:14 pmMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
8h 12m1 stop Denver Intl
$333United Airlines
Tue, Jan 5 - Tue, Jan 12
United Airlines Logo
8:00 am - 6:05 pmSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
7h 05m1 stop Houston George Bush Intcntl
United Airlines Logo
5:00 pm - 9:53 pmMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
7h 53m1 stop Houston George Bush Intcntl
$333United Airlines
Wed, Oct 7 - Wed, Oct 21
Delta Logo
7:02 pm - 6:22 amSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
8h 20m1 stop Salt Lake City
Delta Logo
2:30 pm - 8:56 pmMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
9h 26m1 stop Minneapolis St Paul
$333Delta
Wed, Sep 2 - Sun, Sep 6
Delta Logo
7:05 pm - 6:00 amSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
7h 55m1 stop Salt Lake City
Delta Logo
6:00 am - 12:46 pmMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
9h 46m1 stop Atlanta Hartsfield-Jackson
$333Delta
Thu, Sep 17 - Sat, Sep 26
Multiple Airlines Logo
11:50 am - 12:46 amSNA  Santa Ana J. Wayne/Orange Cnty-MIA Miami
9h 56m1 stop Denver Intl
Multiple Airlines Logo
7:35 am - 9:30 pmMIA  Miami-SNA Santa Ana J. Wayne/Orange Cnty
16h 55m2 stops Phoenix Sky Harbor Intl Seattle/Tacoma Intl
$339Multiple Airlines
Booking Insights

KAYAK's insights & trends for Santa Ana to Florida Keys flights

Get data-powered insights and trends into flights from Santa Ana to Florida Keys to help you find the cheapest flights, the best time to fly and much more.

Can I save money by flying with a layover from John Wayne (Santa Ana) to Florida Keys?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $420, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from John Wayne (Santa Ana) to Florida Keys?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Florida Keys, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from John Wayne (Santa Ana) to Florida Keys is September, when tickets cost $362 (return) on average. On the other hand, the most expensive months are June and March, when the average cost of round-trip tickets is $629 and $609 respectively.

How far in advance should I book a flight from John Wayne (Santa Ana) to Florida Keys?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Santa Ana to Florida Keys, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from John Wayne (Santa Ana) to Florida Keys, you should book around 5 weeks before departure, which saves you about 53% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 21 weeks before departure.

Good to know

Low season

June

Cheapest flight

$116
Best time to beat the crowds but there is an average 19% increase in price.
Most popular time to fly and prices are also 32% lower on average.
Flight from John Wayne (Santa Ana) to Miami

FAQs - booking Florida Keys flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Florida Keys?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Florida Keys.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Florida Keys?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from John Wayne (Santa Ana) to Florida Keys is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Florida Keys?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from John Wayne (Santa Ana) to Florida Keys with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Florida Keys?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from John Wayne (Santa Ana) to Florida Keys up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 5 airlines serving from Santa Ana to Florida Keys

 
See real verified KAYAK customer reviews for airlines flying from John Wayne (Santa Ana) to Florida Keys. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Ana to Florida Keys? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4216 reviews
8.6Crew
8.1Boarding
7.5Entertainment
7.0Food
8.0Comfort
Airline reviews

Red eye from San Diego. Temperature of the cabin was way too warm and the air duct flowed very little air.

6.0 GoodGordon, Jul 2026
Read more Southwest reviews

Red eye from San Diego. Temperature of the cabin was way too warm and the air duct flowed very little air.

Over a 3 hour flight. The turbulence was almost imperceptible except for 2 short periods which were not bad and over quickly. The attendants claimed "Safety first" and sat looking at their phones for 3 hours with no drink or snack service. This isn't the first time with Southwest. I thinkit may be there new plan of operation. Oh, and it was June 18, Southwest's Birthday which offered free drinks. NOT.

The flight was okay. The pilots did an amazing job and kept us updated on the flight. The flight attendants were okay. They found time to be chatty with each other rather than focus on the guests. One of the attendants was a little less warm when asking about my bag I had on my lap that I was using during latter part of the mid- flight. Mind you, it was not the departure descent. I’m respectful to each and every attendant, it was the tone in her voice reminding me to place my carryon bag on the floor. I hope to have a better experience next time.

Terrible. Even though there’s assigned seating now, they are still the slowest boarding airline of anyone.

It was canceled. Supposedly weather. But there was no snow in Baltimore. At least we found out before driving to airport

Okay, not wonderful. Short flight. Wi-fi didn't work properly. Stuck waiting for a gate to open upon arrival for 20 or so minutes.

They sent a notice that they were boarding an hour early. We had to leave the club and run to the gate. They said sorry, that came from corporate and was a mistake. They did not have enough seating because the flight before it had not taken off on time. They moved our gate and delayed it for an hour.

The quality of Southwest Airlines continues to degrade each time I fly with them. If it were not for the free luggage, I would probably choose another airline. Their prices are a little bit competitive, but way too high for the quality of the service. Southwest is not unique in this way. Domestic flight in the United States of America has continued to be a lower and lower quality product. Very sad when you compare the quality of domestic airlines to that of many international airlines around the world.

Great flight, 47 passengers on a 180 seat plane. Stewardess was pleasant and cheerful.

The 700 model seating is too tight both seat size & leg room

overall the crew onboarding and providing service during our flight was great; they were friendly and helpful. I said ok to the entertainment because there was none, but the crew explained why which was very helpful. I am a diabetic and the type of snacks are not diabetic friendly (full of carbs and sugar). However, I am always prepared because I know the catering is for the larger population.

Flight team was great and we even arrived ahead of plan!

We were skipped when the snack cart passed and then the attendant said we weren’t . I am disabled and was in a row toward the back of the plane which was very difficult for me to navigate. Disabled people should not be forced to walk the plank.

Flight was delayed and then "they did not have time to load food". No snack or drink at all for 1.5 how flight. Somebody wasn't prepared.

It is usually very pleasant. Good service for the price, international flights are even better

N Everything was perfect from boarding to assistance to baggage in Tampa

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

Flight was delayed by 3-hours and their fix was… complimentary pretzels.

Flight delayed for two and half hours and then canceled altogether due to mechanical issues. No mechanic onsite to fix so had to send one from LAX.

Flight and seats were great. Food service was average at best. The real main problem we had is that we got cheeseburgers for the kids but the plates was extremely hot. Like ridiculously hot and the stewardess never said anything. Luckily or unluckily my wife touched the plate and was able to deal with it before the kids got burned.

The experience with United Airlines was excellent; however, the experience with Houston Intercontinental Airport (IAH) was horrible. Although our flight departed from Terminal B, we had to go through security in Terminal C and then get on a train for travel to Terminal B. Additionally, there was significant walking required to get to the boarding location.

Flight was delayed 5 hours. Updates kept changing. Sears were extremely cramped. Very little leg room. Flight attendant was rushing through with drinks and hit me in the knee either the cart and didn’t apologize. They gave a 15 dollar voucher in airport which doesn’t buy. Much and it was so late that choices were limited.

Lost one piece of luggage even though I checked in 2.5 hours before the flight

Horrifying Almost 2 million miles. Bring your own food and drink. One coffee or drink every three hours. Have to order meals on app more than 24 hours ahead Tiny and dirty bathrooms

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

They delayed the flight from 9:00 to 11:55 At 11:45 they canceled the flight. I paid a premium price for the tickets with poor service

Not a great experience. We paid for the upgrade for premium economy seats and seated ourselves in very comfortable seats. Someone came along with the same seat on their boarding pass. The aircraft had been changed and as a result we were booted out and sent further back to small uncomfortable seats. After complaining we were moved to emergency row seats, which gave us more leg room but the seats don’t recline. For people in our 70’s we found having to sit upright from California to NJ very uncomfortable. Not sure why they chose to move senior citizens instead of the two people that were allowed to take the more comfortable seats. Not happy.

Very poor the plane itself was really old, slight smell that couldn’t be named. I didn’t even get a boarding pass UNTIL AFTER clearing security! Even then, they said when I get to my connected flight I’ll get my 2nd boarding pass there! A bit ridiculous!

Due to one crew member not showing up to work, our flight was significantly delayed causing us to miss our connecting flight in Houston to Mississippi causing us to be delayed by more than 6 hours and missing our event all together. Very disappointing. All because ONE crew member called in sick. United did grant us a $15 meal voucher, which was a small but appreciated concession that I wasn’t able to use because I ordered my lunch and paid for it before applying the concession, and the staff said it was too late to use it. Ugh! We also had a TWO delay coming back from Mississippi, but that was on American Airlines and it was due to weather, so not their fault. Anyway, not at all impressed with United’s handling of our flight and the HUGE disappointment of missing our important family event for our 90 year old mother. All that money and all that stress and emotions for nothing. Having to wait the hour to bring an employee from LAX seemed like something that should not have happened. Why don’t you have a local back-up? Santa Ana is not a little airport in a rural area.

the head jack on my seat didn't work and the power outlet didn't work for my seat

Gate 461 the worst in LAX Boarding lacks professionalism And as usual, your food sucks.

The WiFi didn’t work entire flight, couldn’t watch a movie. The recline button didn’t work

Was not able to do a online check-in because the American Airlines system doesn't store our visa or other passport information, allowing us to have a trouble-free check-in. We were forced to have to check-in at the counter which Changes are upgrade status given that we were not able to check in much earlier.

The flight was really crowded. Flight attendants were just ok.

Our flight was 1.5 hours delayed. There was no weather for the inbound flight, so I don't understand why. This meant a VERY late arrival and only a quick nap before my morning flight.

The flight encountered a delay exceeding 4 hours. The food voucher issued was valued at $12, insufficient to cover our meal expenses. Consequently, I was unable to take my medication, leading to a drop in blood sugar levels and exacerbating my anxiety.

Flights were on time. That's the main consideration since I had to change planes. The entertainment was whatever you bring with you and the food (in Economy) is non-existant. Neither of those was a surprise.

The gate crew did try to help, however they lacked the information as to whether the flight will operate or not. Being delayed 6 hours and in a limbo on whether the flight will operate or not is not fun. The airline having staffing issues is not encouraging at all.

Flight was delayed and missed connecting flight. Did not give warning about delay until we showed up at the airport. Not good.

I love to be able to connect my own devices to the entertainment system. It works great!

Our flight was delayed 2 hours and when they changed the the time to 1 hour I wasn't alerted and when I checked the gate the plane was still there but they already shut the doors so I had to buy another flight.

The flight was great . But you only had one vegan item on the whole flight and someone prior to me took it . I was so disappointed cause I came in from the flooded area and couldn’t pick up anything prior to my flight .

Plane was hot and miserable and the crew was rude!

My flight was originally from SAT to MCO connecting from MCO to ORD. We got diverted to ATL and than Frontier staff there was sooo un helpful first they said they couldn’t give us any accommodation since our flight first got delayed that cancelled and now it’s 221am and I am still in ATL since they said they need to create a new flight my final destination is ORD and I have been delayed twice and cancelled. With no real help the frontier app didn’t work no email updates over all such a horrible experience

Flight was canceled. Most upsetting was message from Kayak, stating that the flight was canceled and click with Kayak for details regarding rebook, refund details. THERE'S NO INFORMATION PROVIDED BY KAYAK EXCEPT THAT FLIGHT IS CANCELED. AND NOW THIS SURVEY TO FIND OUT HOW WAS THE FLIGHT !!!!!!!

The flight never took off and we spent 7 hours at the airport

I am writing to express my disappointment with my recent Frontier Airlines flight. I was charged $99 at the gate because my bag was said to be too large, yet once onboard there was no available overhead bin space, and I was required to place the bag under the seat in front of me anyway. This made the charge feel unnecessary and unfair. Additionally, before the flight even took off, I was asked to move from the seat I paid for into a middle seat so another passenger and her cat could have my seat to themselves. I was not offered compensation or an explanation for being moved from a paid seat. Between the unexpected bag fee and being forced to give up my seat, this experience fell well below acceptable customer service standards. I would appreciate a review of this situation and appropriate compensation.

One of the worst travel experiences I've had. Had a flight scheduled with CVG to RSW on VLSWQX this morning departing at 5:30. Two individuals at the gate and one was in training. Not her fault but she didn't have the ability to check people in resulting in at least 15 families that didn't make it on the plane because they weren't checked into the system in time. When arriving at the airport to drop off our prepaid checked bags, the bag drop off agent asked if we could check our bags at the gate because of the long line. We said no problem so arrived at the gate by 5:00. They told those people that had previously paid for checked bags to stand off to the side while they let others that either didn't have a checked bag or their bag was already on the plan through. Realizing the gate workers had an issue, they either called for help or this lady showed up late for work as she didn't arrive until 5:15. The worker who had been there training the other individual and working diligently to make sure all passengers got on board. He even said that at one point all people that are currently in line are fine but asked the person in training to stand outside the ticketing area around 5:15 to notify any late travels that the flight was in boarding process and they arrrived too late. At that point, we're sill standing off to the side with our pre-paid checked bags patiently waiting. When the new lady arrived she couldn't have been more rude. It was an awful seen. Essentially they had asked for those without an assigned seat to board last, those with pre-paid checked bag stand off to the site and any traveling with a larger items that needed to be checked at the gate (such as a stroller), wait on the side. They realized that the flight needed to leave on time so the gate attendant shut the gate. So anyone without a seat assignment, those that had pre-checked bags, and the worst one I saw was a mother with two infant children was in line with use because she was asked to stand to the side because her stroller. When they shut the door to the plan they told her she could no longer get on. Her checked bags were already on the plane with her car keys in them, and the lady told her we couldn't accept anyone else on because the door was shut. She didn't even have a way to get home from the airport. Truely evil behavior. I've flown Frontier enough to know customer service is not a top priority in the company's mission, but this was an all-time low. I'm sending this after an 18 hour drive that our family just completed to Bonita Springs . I felt really bad for the lady being trained and the other individual trying to help, but when the new lady came to the gate she was truly one of the rudest individuals I've ever met. One lady had been there since 4am but because she didn't have an assigned seat they wouldn't let her on the plan.

Better than expected. Staff were friendly and nice on both flights.

This airline sucks. They offer low rates then charge you for everything, the app does not work well, the seats are the most uncomfortable. Maintenance issues on the flight, and you still have to sit through their credit card commercials. People are nice enough but does not make up for overall poor experience.

Everything you need to know for your flight to Florida Keys

Information on your arrival and departure airports