RSW - TYS

$130 Find Cheap Flights from Fort Myers to Knoxville - Compare and Save

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Everything you should know

Cheapest round-trip
$259
Typical prices: $328-$605
American Airlines
Sat 12/1Sat 12/8
RSW - TYS • 1 stop
Cheapest one-way
$130
Typical prices: $163-$268
Southwest
Sun 12/16
RSW - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Fort Myers and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
August
Cheapest • 31% price drop
October
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Orlando (MCO)
Cheapest • Avg $265 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 4h 22m (one-way)
Insights
Insights
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Fort Myers to Knoxville (RSW-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Fort Myers to Knoxville

Tue, Dec 1 - Tue, Dec 8
American Airlines Logo
2:32 pm - 7:34 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 02m1 stop Charlotte Douglas
American Airlines Logo
4:17 pm - 9:55 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
5h 38m1 stop Charlotte Douglas
$259American Airlines
Mon, Dec 14 - Fri, Dec 18
Southwest Logo
7:30 am - 12:20 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
4h 50m1 stop Nashville Intl
Southwest Logo
7:15 pm - 12:40 amTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
5h 25m1 stop Nashville Intl
$259Southwest
Tue, Jan 19 - Fri, Jan 22
Southwest Logo
6:05 am - 12:15 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
6h 10m1 stop Nashville Intl
Southwest Logo
6:45 am - 4:00 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
9h 15m1 stop Nashville Intl
$264Southwest
Tue, Jan 19 - Fri, Jan 22
Southwest Logo
6:05 am - 12:15 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
6h 10m1 stop Nashville Intl
Southwest Logo
7:45 am - 4:00 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
8h 15m2 stops Baltimore/Washington Nashville Intl
$264Southwest
Sat, Dec 5 - Mon, Dec 7
Delta Logo
5:20 am - 11:02 amRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 42m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:26 pm - 11:28 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
4h 02m1 stop Atlanta Hartsfield-Jackson
$277Delta
Fri, Dec 4 - Fri, Dec 11
Delta Logo
5:20 am - 11:27 amRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
6h 07m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 11:57 amTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
6h 17m1 stop Atlanta Hartsfield-Jackson
$277Delta
Thu, Dec 10 - Sun, Dec 13
American Airlines Logo
7:19 pm - 11:59 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
4h 40m1 stop Charlotte Douglas
American Airlines Logo
6:02 pm - 11:04 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
5h 02m1 stop Charlotte Douglas
$282American Airlines
Thu, Dec 10 - Sun, Dec 13
American Airlines Logo
2:32 pm - 7:30 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
4h 58m1 stop Charlotte Douglas
American Airlines Logo
6:02 pm - 11:04 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
5h 02m1 stop Charlotte Douglas
$282American Airlines
Fri, Dec 11 - Sun, Dec 13
Delta Logo
6:27 pm - 11:57 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 30m1 stop Atlanta Hartsfield-Jackson
Delta Logo
7:26 pm - 12:42 amTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
5h 16m1 stop Atlanta Hartsfield-Jackson
$300Delta
Mon, Dec 28 - Fri, Jan 1
American Airlines Logo
3:55 pm - 9:57 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
6h 02m1 stop Charlotte Douglas
American Airlines Logo
8:01 pm - 12:38 amTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
4h 37m1 stop Charlotte Douglas
$304American Airlines
Booking Insights

Price, demand and travel trends for Fort Myers to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

How much is a round-trip flight from Fort Myers to Knoxville?

Round-trip flights from Fort Myers to Knoxville typically range from $328 to $605. The lowest price found in the past 5 days was $259, on American Airlines.

What's the cheapest day of the week to fly from Fort Myers to Knoxville?

Based on deals KAYAK users found in the last 12 months, Friday is the cheapest day of the week to fly from Fort Myers to Knoxville. It’s 9% cheaper than the average day, while Saturday is the most expensive, with prices 69% higher.

What’s the cheapest month to fly from Fort Myers to Knoxville?

•August is the cheapest month to fly from Fort Myers to Knoxville at $268 round-trip.
•January ($715) and November ($658) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 166% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Fort Myers to Knoxville flights

Low season

July

Cheapest flight

$130
Beat the crowds with an average 42% drop in travelers.
The most popular month to fly with an average 35% increase in travelers.
One-way flight from Fort Myers to Knoxville

When to book flights from Fort Myers to Knoxville

Are your dates flexible? Find out the best times to travel from Fort Myers to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Fort Myers to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Fort Myers to Knoxville?

    Only Economy Class is available on flights from Fort Myers to Knoxville.

  • How long is a flight from Fort Myers to Knoxville?

    A nonstop flight from Fort Myers to Knoxville takes 00m, covering 653 miles.

  • Do I need a passport to fly from Fort Myers to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Fort Myers to Knoxville flight?

    Round-trip flights from Fort Myers to Knoxville range from $328 to $605, with an average of $389 over the past 12 months. Anything below $328 counts as a good deal.

  • Have flight prices from Fort Myers to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $259 to $1,370. That means the highest observed fare was about 5x higher than the lowest one.

  • How are flight prices from Fort Myers to Knoxville looking right now?

    One-way fares from Fort Myers to Knoxville are currently in line with typical prices for this route. Average one-way fares are about $207.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $82 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from Fort Myers to Knoxville?

    Flights from Fort Myers to Knoxville usually depart from Fort Myers SW Florida Intl (RSW) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Fort Myers to Knoxville pass through?

    One-stop flights from Fort Myers to Knoxville most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 64% of one-stop connections
    • Charlotte Douglas (CLT) - 34% of one-stop connections
    • Orlando (MCO) - 1% of one-stop connections

  • Can I save money by using flexible dates for flights from Fort Myers to Knoxville?

    Yes. Flexible dates can save you up to 47% on flights from Fort Myers to Knoxville. Friday is the cheapest departure day at $354 round-trip on average, while Saturday is the most expensive at $658, a difference of $304.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Fort Myers to Knoxville?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 22m, compared with 4h 32m via Charlotte Douglas (CLT) and 7h 27m via Orlando (MCO).

Your guide to booking Fort Myers to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Friday departure and avoid flying on Saturday. On this route, Friday flights average $354, about $304 less than Saturday fares (46% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Fort Myers to Knoxville trip for August. Fares historically average $268 round-trip in that month - typically $447 less than the most expensive month, which is January (based on the last 12 months).

More options for your flight from Fort Myers to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

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