RSW - TYS

$160 Find Cheap Flights from Fort Myers to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Fort Myers to Knoxville departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Fort Myers to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Fort Myers to Knoxville, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$291
Overall average: $321
American Airlines
Sat 5/23Wed 5/27
RSW - TYS • 1 stop
Cheapest one-way
$160
American Airlines
Thu 8/20
RSW - TYS • 1 stop
Top airlines
Cheapest • from $291 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Fort Myers and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $365 (round-trip)
Shortest trip • 4h 15m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 28% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Fort Myers to Knoxville (RSW-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Fort Myers to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Fort Myers to Knoxville

Sat, May 23 - Wed, May 27
American Airlines Logo
6:15 am - 12:18 pm
RSW
-
TYS
6h 03m
1 stop
American Airlines Logo
5:00 am - 9:07 am
TYS
-
RSW
4h 07m
1 stop
$291American Airlines
Thu, Jul 23 - Thu, Jul 30
American Airlines Logo
7:41 pm - 11:51 pm
RSW
-
TYS
4h 10m
1 stop
American Airlines Logo
5:03 am - 9:08 am
TYS
-
RSW
4h 05m
1 stop
$319American Airlines
Sat, May 23 - Wed, May 27
Delta Logo
5:35 am - 9:34 am
RSW
-
TYS
3h 59m
1 stop
Delta Logo
1:59 pm - 8:44 pm
TYS
-
RSW
6h 45m
1 stop
$325Delta
Sat, May 23 - Wed, May 27
Delta Logo
5:35 am - 11:11 am
RSW
-
TYS
5h 36m
1 stop
Delta Logo
7:33 pm - 12:27 am
TYS
-
RSW
4h 54m
1 stop
$343Delta
Sat, Apr 25 - Sat, May 2
Southwest Logo
6:45 am - 1:20 pm
RSW
-
TYS
6h 35m
1 stop
Southwest Logo
6:40 am - 4:15 pm
TYS
-
RSW
9h 35m
1 stop
$349Southwest
Fri, Jul 31 - Tue, Aug 4
Delta Logo
7:56 pm - 11:46 pm
RSW
-
TYS
3h 50m
1 stop
Delta Logo
5:57 pm - 12:36 am
TYS
-
RSW
6h 39m
1 stop
$352Delta
Sat, Apr 25 - Sat, May 2
Southwest Logo
6:25 am - 1:20 pm
RSW
-
TYS
6h 55m
2 stops
Southwest Logo
6:40 am - 4:15 pm
TYS
-
RSW
9h 35m
1 stop
$355Southwest
Sat, Apr 25 - Sat, May 2
Southwest Logo
6:25 am - 1:20 pm
RSW
-
TYS
6h 55m
2 stops
Southwest Logo
6:40 am - 6:45 pm
TYS
-
RSW
12h 05m
2 stops
$360Southwest
Thu, Jul 2 - Fri, Jul 3
Delta Logo
5:35 am - 9:11 am
RSW
-
TYS
3h 36m
1 stop
Delta Logo
5:30 am - 9:58 am
TYS
-
RSW
4h 28m
1 stop
$361Delta
Fri, Jul 31 - Tue, Aug 4
Southwest Logo
6:05 am - 3:45 pm
RSW
-
TYS
9h 40m
2 stops
Southwest Logo
8:00 am - 7:50 pm
TYS
-
RSW
11h 50m
2 stops
$368Southwest
Booking Insights

KAYAK's insights & trends for Fort Myers to Knoxville flights

Get data-powered insights and trends into flights from Fort Myers to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Fort Myers to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Fort Myers to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Fort Myers to Knoxville is September, where tickets cost $313 (return) on average. On the other hand, the most expensive months are January and March, where the average cost of round-trip tickets is $715 and $626 respectively.

Good to know

Low seasonMarch
Cheapest flight$160
Best time to beat the crowds but there is an average 44% increase in price.
Most popular time to fly and prices are also 15% lower on average.
Flight from Fort Myers to Knoxville

When to book flights from Fort Myers to Knoxville

Are your dates flexible? Find out the best times to travel from Fort Myers to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Fort Myers to Knoxville

  • What is the cheapest flight from Fort Myers to Knoxville?

    In the last 3 days, the lowest price for a flight from Fort Myers to Knoxville was $160 for a one-way ticket and $291 for a round-trip.

  • Do I need a passport to fly between Fort Myers and Knoxville?

    No

  • Which airports will I be using when flying from Fort Myers to Knoxville?

    Fort Myers airport is called Fort Myers SW Florida Intl and the only airport in Knoxville is Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Fort Myers to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Fort Myers to Knoxville?

    oneworld, and SkyTeam are the airline alliances operating flights between Fort Myers and Knoxville, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from Fort Myers to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Fort Myers to Knoxville are Delta and American Airlines. With an average price for the route of $370 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $398 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Fort Myers to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Fort Myers to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Fort Myers to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Fort Myers is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Fort Myers to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Fort Myers with another airline. Booking your flights between Fort Myers and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Fort Myers to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Fort Myers up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airlines flying from Fort Myers to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Fort Myers to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Fort Myers to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8286 reviews
7.9Comfort
7.2Food
8.1Boarding
8.5Crew
7.8Entertainment
Airline reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

10.0 ExcellentDebra, Mar 2026
PBI - ATL
Read more Delta reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

Same experience as the flight from Norfolk to Atlanta where people are boarded in zones that don't make sense. People behind you on the plane will get on before you and they take the luggage space on your row.

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

Smallest leg room I've ever had on a plane.

The flight was great as well as the airline staff

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Flights were constantly delayed. CRW took 50 minutes to get bags

Where do I start!! I was delayed with my flight from Dallas to Tampa. On the way back from Tampa to Dallas the flight was delayed over 4 hours+. I was put on another flight that was also delayed but not as long. Traveling on American Airlines is becoming exhausing.

I didn't end up taking this flight. I got up at 4am for a flight that was supposed to board at 6am - at 5:55am you delayed the flight to 10am. The airport is under construction so I switched to a later flight as I wasn't going to sit in the airport for 4 hours. They said the delay was due to the crew needing rest from a flight coming in late the night before - if that was the case then I think you should have delayed the flight much sooner so that passengers wouldn't get up so early and get to the airport to sit and wait.

The flight attendants and the service is getting worse by the day.

Other than nearly three hour delay for maintenance issues, everything went smooth

why would I bother with this airline and pick seats when I am asked to move for a weight imbalance

Overall good. The pilots and flight attendants are excellent! The equipment was the issue on my First flight as they had to wait for a part to be installed. So the take off was at least 30 minutes later.

For my arriving destination, we were delayed multiple times to the point that we arrived 6 hours after we were originally scheduled. On my flight home, they overbooked and involuntarily removed passengers (including me) from the plane. It was not a good experience.

Everything you need to know for your flight from Fort Myers to Knoxville

Information on your arrival and departure airports