RSW - TYS

$138 Find Cheap Flights from Fort Myers to Knoxville - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$215
Typical prices: $328-$477
American Airlines
Sun 11/4Wed 11/7
RSW - TYS • 1 stop
Cheapest one-way
$137
Typical prices: $165-$319
Southwest
Mon 1/29
RSW - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Fort Myers and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
September
Cheapest • 12% price drop
August
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Orlando (MCO)
Cheapest • Avg $265 (round-trip)
Atlanta Hartsfield-Jackson (ATL)
Shortest trip • 4h 26m (one-way)
Insights
Insights
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Flight Deals

Cheap Flights from Fort Myers to Knoxville (RSW-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Fort Myers to Knoxville

Wed, Nov 4 - Sat, Nov 7
American Airlines Logo
4:47 pm - 10:48 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
6h 01m1 stop Charlotte Douglas
American Airlines Logo
6:01 am - 10:17 amTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
4h 16m1 stop Charlotte Douglas
$215American Airlines
Tue, Oct 27 - Wed, Nov 18
American Airlines Logo
1:14 pm - 6:43 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 29m1 stop Charlotte Douglas
American Airlines Logo
4:12 pm - 9:51 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
5h 39m1 stop Charlotte Douglas
$215American Airlines
Sat, Nov 7 - Wed, Nov 11
Southwest Logo
2:30 pm - 7:50 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 20m1 stop Baltimore/Washington
Southwest Logo
7:05 am - 2:00 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
6h 55m1 stop Nashville Intl
$218Southwest
Tue, Oct 27 - Wed, Nov 18
Southwest Logo
3:10 pm - 8:10 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 00m1 stop Baltimore/Washington
Southwest Logo
1:00 pm - 10:00 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
9h 00m1 stop Orlando
$220Southwest
Tue, Oct 27 - Wed, Nov 18
Southwest Logo
3:10 pm - 8:10 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 00m1 stop Baltimore/Washington
Southwest Logo
1:00 pm - 10:00 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
9h 00m1 stop Orlando
$220Southwest
Wed, Oct 21 - Wed, Nov 18
Delta Logo
5:30 am - 10:54 amRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 24m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 9:47 amTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
4h 07m1 stop Atlanta Hartsfield-Jackson
$225Delta
Wed, Oct 14 - Wed, Dec 2
Delta Logo
5:30 am - 9:34 amRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
4h 04m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:17 pm - 12:42 amTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
6h 25m1 stop Atlanta Hartsfield-Jackson
$230Delta
Wed, Oct 14 - Wed, Oct 21
Delta Logo
8:09 am - 1:40 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 31m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 9:50 amTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
4h 10m1 stop Atlanta Hartsfield-Jackson
$230Delta
Sat, Jan 9 - Wed, Jan 13
American Airlines Logo
4:46 pm - 10:53 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
6h 07m1 stop Charlotte Douglas
American Airlines Logo
12:30 pm - 5:59 pmTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
5h 29m1 stop Charlotte Douglas
$259American Airlines
Sun, Nov 1 - Sat, Nov 7
American Airlines Logo
2:32 pm - 7:34 pmRSW  Fort Myers SW Florida Intl-TYS Knoxville McGhee Tyson
5h 02m1 stop Charlotte Douglas
American Airlines Logo
6:01 am - 10:17 amTYS  Knoxville McGhee Tyson-RSW Fort Myers SW Florida Intl
4h 16m1 stop Charlotte Douglas
$272American Airlines
Booking Insights

Price, demand and travel trends for Fort Myers to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Fort Myers to Knoxville with more confidence.

How much is a round-trip flight from Fort Myers to Knoxville?

Round-trip flights from Fort Myers to Knoxville start at $215. Prices are below average for this route right now, with typical round-trip fares ranging from $328 to $477. The lowest price found in the past 5 days was $215 on American Airlines.

What's the cheapest day of the week to fly from Fort Myers to Knoxville?

Friday is the cheapest day of the week to fly from Fort Myers to Knoxville, it is 6% cheaper than the average day. Thursday is the most expensive day with flight prices 32% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from Fort Myers to Knoxville?

•September is the cheapest month to fly from Fort Myers to Knoxville at $328 round-trip.
•January ($715) and December ($646) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 117% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Fort Myers to Knoxville flights

Low season

February

Cheapest flight

$137
Best time to beat the crowds but there is an average 23% increase in price.
Flight from Fort Myers to Knoxville

When to book flights from Fort Myers to Knoxville

Are your dates flexible? Find out the best times to travel from Fort Myers to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Fort Myers to Knoxville flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Fort Myers to Knoxville?

    Flights from Fort Myers to Knoxville usually depart from Fort Myers SW Florida Intl (RSW) and arrive at Knoxville McGhee Tyson (TYS).

  • What cabin classes can I book on flights from Fort Myers to Knoxville?

    Only Economy Class is available on flights from Fort Myers to Knoxville.

  • Which airports do connecting flights from Fort Myers to Knoxville pass through?

    One-stop flights from Fort Myers to Knoxville most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 56% of one-stop connections
    • Charlotte Douglas (CLT) - 42% of one-stop connections
    • Orlando (MCO) - 1% of one-stop connections
    • Chicago O'Hare Intl (ORD) - 1% of one-stop connections

    Atlanta Hartsfield-Jackson (ATL) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Fort Myers to Knoxville?

    Yes. Being flexible with your travel dates can save you up to 29% on the Fort Myers to Knoxville route. Friday is the cheapest departure day at $354 round-trip on average, while Thursday is the most expensive at $494, a difference of $140. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How long is a flight from Fort Myers to Knoxville?

    A nonstop flight from Fort Myers to Knoxville takes 0h 00m, covering 653 miles.

  • Do I need a passport to fly from Fort Myers to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Fort Myers to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $215 to $1,392. That means the highest observed fare was about 6x higher than the lowest one.

  • How are flight prices from Fort Myers to Knoxville looking right now?

    One-way fares from Fort Myers to Knoxville are currently lower than usual. Average one-way flight prices are about $190, which is 12% below the typical average for this route.

  • How much time can I save by choosing a different layover airport from Fort Myers to Knoxville?

    Flying via Atlanta Hartsfield-Jackson (ATL) gives the shortest average 1-stop total travel time at 4h 26m, compared with 4h 28m via Charlotte Douglas (CLT) and 6h 11m via Chicago O'Hare Intl (ORD).

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
    • Budget
    • Alamo
    • Thrifty
    • Enterprise Rent-A-Car
    • Payless

  • How much should I expect to pay for a Fort Myers to Knoxville flight?

    Round-trip flights from Fort Myers to Knoxville range from $328 to $477, with an average of $373 over the past 12 months. Anything below $328 counts as a good deal.

Your guide to booking Fort Myers to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Friday departure instead of Thursday. On this route, Friday flights average $354 - about $140 less than Thursday (28% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Fort Myers to Knoxville trip for September. Fares historically average $328 round-trip in that month - typically $387 less than the most expensive month, which is January (based on the last 12 months).

More options for your flight from Fort Myers to Knoxville

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