GSP - PTY

$497 Find Cheap Flights from Greenville to Panama City

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Greenville to Panama City departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Panama City

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Greenville to Panama City, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Greenville to Panama City, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$497
American Airlines
Tue 9/15Thu 10/15
GSP - PTY • 1 stop
Cheapest one-way
$219
Delta
Tue 5/5
GSP - PTY • 1 stop
Top airlines
American Airlines
Cheapest • from $497 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Greenville and Panama City. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Atlanta (ATL)
Cheapest • Avg $553 (round-trip)
Atlanta (ATL)
Shortest trip • 7h 01m (one-way)
Insights
Insights
Insights
Insights
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Panama City!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Greenville to Panama City (GSP-PTY)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Greenville to Panama City that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Greenville to Panama City

Tue, Sep 15 - Thu, Oct 15
American Airlines Logo
5:55 am - 2:10 pm
GSP
-
PTY
9h 15m
1 stop
American Airlines Logo
3:35 pm - 11:14 pm
PTY
-
GSP
6h 39m
1 stop
$497American Airlines
Tue, Sep 15 - Thu, Oct 15
American Airlines Logo
5:38 am - 2:10 pm
GSP
-
PTY
9h 32m
2 stops
American Airlines Logo
3:35 pm - 8:08 am
PTY
-
GSP
15h 33m
2 stops
$501American Airlines
Tue, Apr 28 - Tue, May 5
American Airlines Logo
6:00 am - 12:46 pm
GSP
-
PTY
7h 46m
1 stop
American Airlines Logo
1:49 pm - 11:59 pm
PTY
-
GSP
9h 10m
1 stop
$503American Airlines
Tue, Sep 15 - Thu, Oct 15
United Airlines Logo
7:00 am - 6:37 pm
GSP
-
PTY
12h 37m
1 stop
United Airlines Logo
3:20 pm - 9:46 pm
PTY
-
GSP
29h 26m
1 stop
$506United Airlines
Mon, May 4 - Thu, May 7
United Airlines Logo
7:35 pm - 2:14 pm
GSP
-
PTY
19h 39m
2 stops
United Airlines Logo
10:00 am - 9:47 am
PTY
-
GSP
22h 47m
2 stops
$507United Airlines
Sat, May 2 - Wed, May 6
Delta Logo
6:51 am - 1:02 pm
GSP
-
PTY
7h 11m
1 stop
Delta Logo
2:27 pm - 11:56 pm
PTY
-
GSP
8h 29m
1 stop
$521Delta
Sat, Aug 15 - Fri, Aug 21
American Airlines Logo
7:39 pm - 2:20 pm
GSP
-
PTY
19h 41m
2 stops
American Airlines Logo
3:20 pm - 3:32 pm
PTY
-
GSP
23h 12m
2 stops
$522American Airlines
Mon, May 4 - Thu, May 7
United Airlines Logo
7:35 pm - 4:12 pm
GSP
-
PTY
21h 37m
2 stops
United Airlines Logo
3:30 pm - 10:14 pm
PTY
-
GSP
29h 44m
1 stop
$533United Airlines
Mon, Jul 6 - Mon, Jul 13
United Airlines Logo
7:49 pm - 4:04 am
GSP
-
PTY
9h 15m
1 stop
United Airlines Logo
10:55 pm - 10:37 am
PTY
-
GSP
10h 42m
1 stop
$535United Airlines
Mon, Jul 6 - Mon, Jul 13
United Airlines Logo
7:49 pm - 4:04 am
GSP
-
PTY
9h 15m
1 stop
United Airlines Logo
10:55 pm - 5:00 pm
PTY
-
GSP
17h 05m
2 stops
$539United Airlines
Booking Insights

KAYAK's insights & trends for Greenville to Panama City flights

Get data-powered insights and trends into flights from Greenville to Panama City to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Greenville to Panama City?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Greenville to Panama City departing in September.
Find deals

Good to know

Low seasonAugust
Cheapest flight$497
Best time to beat the crowds with an average 34% drop in price.
Most popular time to fly and prices are also 13% lower on average.
Flight from Greenville to Panama City

When to book flights from Greenville to Panama City

Are your dates flexible? Find out the best times to travel from Greenville to Panama City based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Greenville to Panama City

  • What is the cheapest flight from Greenville to Panama City?

    In the last 3 days, the lowest price for a flight from Greenville to Panama City was $219 for a one-way ticket and $497 for a round-trip.

  • Do I need a passport to fly between Greenville and Panama City?

    Yes, you'll most likely have to show a valid passport before boarding the plane in Greenville and on arrival in Panama City.

  • Which airports will I be using when flying from Greenville to Panama City?

    On your way to Panama City, you’ll fly out from Greenville. You’ll be landing at Panama City Tocumen Intl.

  • Which aircraft models fly most regularly from Greenville to Panama City?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from Greenville to Panama City?

    SkyTeam is the only airline alliance operating flights between Greenville and Panama City.

  • Which is the best airline for flights from Greenville to Panama City, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Greenville to Panama City are Delta and American Airlines. With an average price for the route of $452 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $613 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Greenville to Panama City?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Greenville to Panama City.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Greenville to Panama City?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Panama City from Greenville is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Greenville to Panama City?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Panama City with an airline and back to Greenville with another airline. Booking your flights between Greenville and PTY can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Greenville to Panama City?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Panama City from Greenville up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top airline flying from Greenville to Panama City

 
See real verified KAYAK customer reviews for airlines flying from Greenville to Panama City. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Greenville to Panama City? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8356 reviews
7.2Food
8.1Boarding
8.5Crew
7.8Entertainment
7.9Comfort
Airline reviews

Delta is always a wonderful experience. A clean plane and the crew is really friendly.

10.0 ExcellentCharlean, Mar 2026
LAS - ATL
Read more Delta reviews

Delta is always a wonderful experience. A clean plane and the crew is really friendly.

Too many people are taking up space in the overhead bins with their extra piece of luggage. Since they cannot fit their backpacks or extra luggage piece under the seat in front of them, they store it in the overheads and thus taking up room for other passengers. It wasn’t only one or two persons; more like 12 or 13 passengers.

Excellent service, I love the soft blush pink mood lighting on the 767-400ER during meal service. The overhead gasper vents on the 767-400ER were also very strong with a lot of airflow to keep me comfortable on my flight.

This was the worse experience. They delayed our flight twice and we still had to find another flight to get home sooner which was alos delayed. Also, the flight attendant named Ginny on DL9890 leaving at 4:13pm on 3/23/26 was extremely rude.

I love Delta the flight attendants were personable and the flight arrived 1/2 earlier thanks expected. All a plus. The gate agent was a bit flustered but even with that I still had a good experience. Her supervisor assisted me.

Got to fly my favorite plane, the Boeing 767-400ER, to Milan. The soft blush pink mood lighting during meal service was very beautiful and gorgeous. The service was top-notch, and our flights were on time. I highly recommend Delta.

I am still at the Airport! Delayed Delayed and Delyaed

I took seat 15A in anticipation of window seat, there is no window.

The first class flight attendant was awful to everyone. Very rude; no customer service. She should not be working in first class.

Snacks and included beverages were appreciated. Boarding went smoothly. Plenty of overhead bin space. Seats get very uncomfortable after a couple of hours. After waiting 10 painful minutes for my walker, a very nice Delta guest agent pushed me in a wheelchair to the gate. It was finally delivered to me after another 15 minutes . Our checked bag was on the carousel long b4 I was able to retrieve it. Fortunately it was still there but somewhere along the way the straps we used to secure it were removed and and were not reattached. Wish I had made note of the agents name.

Everything you need to know for your flight from Greenville to Panama City

Information on your arrival and departure airports

Greenville (GSP)
Panama City (PTY)