$46 Find Cheap Flights from Indianapolis to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from Indianapolis to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charlestonnonstop$83
Myrtle Beach
Myrtle Beachnonstop$74
Greenville
Greenville1 stop$216
Columbia
Columbia1 stop$263
Charlotte
Charlotte1 stop$210
Charleston
Charlestonnonstop$83
Myrtle Beach
Myrtle Beachnonstop$74
Greenville
Greenville1 stop$216
Columbia
Columbia1 stop$263
Charlotte
Charlotte1 stop$210

Book Cheap Indianapolis to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Indianapolis to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Indianapolis to South Carolina

Sat, Aug 1 - Sat, Aug 8
Allegiant Air Logo
6:10 am - 7:56 am
IND
-
MYR
1h 46mnonstop
Allegiant Air Logo
8:51 am - 10:45 am
MYR
-
IND
1h 54mnonstop
$74Allegiant Air
Mon, Jul 20 - Fri, Jul 31
Allegiant Air Logo
6:51 pm - 8:41 pm
IND
-
CHS
1h 50mnonstop
Allegiant Air Logo
9:37 pm - 11:31 pm
CHS
-
IND
1h 54mnonstop
$83Allegiant Air
Sat, Aug 22 - Mon, Aug 24
American Airlines Logo
6:48 pm - 10:50 pm
IND
-
GSP
4h 02m
1 stop
American Airlines Logo
6:34 pm - 11:58 pm
GSP
-
IND
5h 24m
1 stop
$227American Airlines
Sat, Aug 8 - Mon, Aug 10
Southwest Logo
6:35 am - 12:15 pm
IND
-
GSP
5h 40m
1 stop
Southwest Logo
4:40 pm - 10:20 pm
GSP
-
IND
5h 40m
1 stop
$228Southwest
Sat, Aug 22 - Tue, Aug 25
Southwest Logo
2:30 pm - 5:30 pm
IND
-
GSP
3h 00m
1 stop
Southwest Logo
1:20 pm - 10:45 pm
GSP
-
IND
9h 25m
2 stops
$234Southwest
Wed, Sep 2 - Wed, Sep 9
United Airlines Logo
5:45 am - 9:47 am
IND
-
CAE
4h 02m
1 stop
United Airlines Logo
2:15 pm - 8:14 pm
CAE
-
IND
5h 59m
1 stop
$263United Airlines
Wed, Sep 2 - Wed, Sep 9
United Airlines Logo
6:00 am - 2:21 pm
IND
-
CAE
8h 21m
2 stops
United Airlines Logo
10:22 am - 2:22 pm
CAE
-
IND
4h 00m
1 stop
$268United Airlines
Fri, Sep 11 - Mon, Sep 14
American Airlines Logo
10:32 am - 4:19 pm
IND
-
CAE
5h 47m
1 stop
American Airlines Logo
7:33 pm - 11:41 pm
CAE
-
IND
4h 08m
1 stop
$303American Airlines
Wed, Sep 16 - Wed, Sep 23
Delta Logo
6:10 am - 11:31 am
IND
-
HHH
5h 21m
1 stop
Delta Logo
4:10 pm - 11:59 pm
HHH
-
IND
7h 49m
2 stops
$328Delta
Mon, Aug 10 - Mon, Aug 17
Delta Logo
7:02 am - 11:09 am
IND
-
CAE
4h 07m
1 stop
Delta Logo
7:47 pm - 12:27 am
CAE
-
IND
4h 40m
1 stop
$331Delta
Booking Insights

KAYAK's insights & trends for Indianapolis to South Carolina flights

Get data-powered insights and trends into flights from Indianapolis to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Indianapolis to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Indianapolis to South Carolina departing in July.

What is the cheapest Indianapolis to South Carolina flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South Carolina from Indianapolis found in the last 5 days was to Charleston, at $74 round-trip. The most popular route is from Indianapolis (IND) to Charleston (CHS), and the cheapest round-trip airline ticket found on this route in the last 5 days was $74.

What is the cheapest time of day to fly to South Carolina?

The average price for all round-trip flights from Indianapolis to South Carolina depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to South Carolina is generally in the evening, when round-trip flights cost $113 on average. Morning departures are around 60% more expensive than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the morning, which is peak travel time and where the average cost of a ticket is $181.

Can I save money by flying with a layover from Indianapolis to South Carolina?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $211, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Indianapolis to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Indianapolis to South Carolina is July, when tickets cost $45 (return) on average. On the other hand, the most expensive months are April and January, when the average cost of round-trip tickets is $270 and $185 respectively.

How far in advance should I book a flight from Indianapolis to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Indianapolis to South Carolina, you should book around 4 weeks before departure, which saves you about 59% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 7 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$46
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 16% lower on average.
Flight from Indianapolis to Myrtle Beach

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Indianapolis to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Indianapolis to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Indianapolis to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Indianapolis to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Indianapolis to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Indianapolis to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Indianapolis to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Indianapolis to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • How many flights are there between Indianapolis and South Carolina per day?

    There is a maximum of 1 nonstop flight a day that takes off from Indianapolis and lands in South Carolina, with an average flight time of 1h 50m. The most common departure time is 6:00 pm and most flights take off in the evening. Each week, there are 3 flights.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Indianapolis to the following destinations at these prices or less: Charlotte $178 one-way - $358 round-trip

Reviews of the top 5 airlines serving from Indianapolis to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Indianapolis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Indianapolis to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4250 reviews
8.0Comfort
7.5Entertainment
7.0Food
8.6Crew
8.1Boarding
Airline reviews

Overall good, just screaming kids in the area the whole flight.

8.0 ExcellentAnonymous, Jul 2026
MDW - MHT
Read more Southwest reviews

Overall good, just screaming kids in the area the whole flight.

My experience will Southwest was good. I wish there was more entertainment and the boarding process was slow at time but other than that my experience was great definitely will be flying with SouthWest again.

Flight was delayed by 2 hours, meaning that a flight to Dwnver which should have arrived at 11pm came into the airport at 1 am. Made for a very long day.

I think Southwest is the number one airline that anyone can fly I have flown for the first time Frontier and what a joke and their customer service United was a very strange experience I'm only sticking to Southwest from here on out for sure

Great job! My family doesnt fly often but we felt safe 100%

Great job Southwest! My family doesn't fly often but we felt safe the whole time.

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Only one drink pass through the cabin for a 4 hour flight. Quite rough and bumpy landing.

Excellent! Only question is how we check in at exactly 24 hours in advance and end up at the end of the B boarding group

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

Extremely dosappoontined and frustrated. Refused entry to lounge in Detroit despite having Delta AMEX Reserve linked in MyDelta phone app as revommended and also having proof of account. No pillows were available for overnight flight to AMS and breakfast was not served in Delta Comfort.

All good on Delta's part. Passengers could be a little more courteous to each other.

The pilots were good. Disappointing when planes don't have electrical ports

Delta flight overall it was goodT!the crew could do more and the food could be better.

No complaints - left 20 minutes later than planned but still arrived on time.

Boarded from a very small gate at LAX. Staff at gate had us line up, then waited 25 minutes to board without a word of explanation. Plane arrived on time then waited 20 minutes for a plane to vacate our gate. Majority of bags arrived after 15 minutes but it took an hour for a small number of remaining bags to be off-loaded despite my “priority” bag tag.

It's fine but Newark to Nashville was too long

The flight was delayed because they closed several flight ways because of air shows, fire works, etc.

Horrible experience. They delayed our flight 7 hours!! We had to seat at the airport with kids on 4th July all day!

Excellent flight. On time. Great staff. Clean and crisp cabin.

The flight was delayed by a hour and I wish they had communicated it sooner. No issues on the plane, it did take a while for food to come.

Know that the movies that you are going to be offered are the oldest be rated movies they could possibly get. They may have one or two new movies that they keep advertising but when you’re flying 15 hours, there is nothing to see past the first new movie.

Great staff. Clean plane, but we were delayed for more than an hour due to maintenance issues and had to board another plane.

Awful. No counter attendants. No dinner offered due to delays.

Flight was great. On time. Pleasant crew and responsible passengers. My only disappointment was that there was no coffee or tea offered. It was a short flight but a coffee would have been appreciated for what the price of tickets are now.

A very pleasant flight but it would be greatly improved with wifi to help entertain kids

This is a no frills, get it done, efficient airline. The seat is a lawn chair. You better bring your own entertainment. If you want something other than water you need to pay for it. But they will get you to your destination quickly, on time, and then they will turn the flight around and go right back where they came from. Reliably. Couple times a week tops. If it fits into your schedule, you can’t get there cheaper or faster.

A three hour delay to board and then another hour on the tarmac because they couldn't get a tractor? Ugh.

Allegiant canceled the flight. The flight the next day was full. Allegiant did not provide any compensation besides a refund. Last time on Allegiant.

Seats were very uncomfortable and being charged for snacks and water.........

Allegiant actually impressed me, original inbound flight from PBG was so late they gave us a bird inbound from Des Moines and only left 1h late and gained 40 minutes back in the air. Comfortable flight with no frills but no complaints.

It was canceled. The flight wasn’t rescheduled, everyone had to figure out their own new arrangements. They said we would get refunded our original fare and receive an additional $150. We received links for $100 only and they expired before we could activate them.

I didn't even take this flight. My plans changed and I couldn't get ahold of customer service and the website kept breaking down during the attempt to change the flight. I wound up taking another airline entirely and eating the cost.

We had a 4-hour delay due to a maintenance issue. We boarded, deplaned, then boarded again.

No frills, value airline. This trip was exactly what I expected. The flight was on time departing and arrived ahead of schedule. The crew was very efficient at getting people on and off the plane. I think the carry-on bag charges discouraged most people from bringing one, which led to quicker de-planing. I was careful to only bring a carefully packed personal item that was under the size limit. If you keep in mind that everything costs extra with this airline (including snacks, drinks, and printing boarding passes), and go into this with the right expectations, then all will be well. For the price difference, I would fly this airline again. My flight was only 1 hr. 20 minutes though. Much longer than that and comfort might drive me to another airline. The seats are very basic and don't recline at all.

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

The Mario was so helpful and provided amazing customer service however l have being waiting for a callback for almost a week now and have not heard anything further after l informed them l wanted to change my date of traveling because of my hospital appointment even send them proof and l was unable to use manag your booking on their website is a bit frustrating and l would appreciate an update on My request as soon as possible. And have called them times without numbers no response

Poor seat in rear of aircraft Food at Admiral’s Club Terminal D at DFW inedible

There is no room, no gluten free options, or any free internet/entertainment. You have to bring your own tablet or smartphone because there are no screens.

April was the flight attendant in first class and was the most pleasant, cordial and efficient person I have seen on a flight in years. Good example of the type of people AA should hire to increase customer satisfacdtion.

Excellent accommodating crew at gate and on board. Baggage claim and gate checking were flawless.

Delayed 6 times. Eventually rebooked and missed a whole day of my vacation. Hot mess

Unfriendly gate staff and significant delay once we were on the plane.

I am tired of being nickel and dimed for seat location, checked luggage and carry on bags. That is why i rarely fly anymore.

Did not get to Ontario yet. Sitting on tarmac for 2 plus hours.

Everything you need to know for your flight from Indianapolis to South Carolina

Information on your arrival and departure airports