$59 Find Cheap Flights from Indianapolis to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 8/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from Indianapolis to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$213
Myrtle Beach
Myrtle Beach1 stop$271
Greenville
Greenville2 stops$245
Columbia
Columbia1 stop$293
Charlotte
Charlotte1 stop$211
Charleston
Charleston1 stop$213
Myrtle Beach
Myrtle Beach1 stop$271
Greenville
Greenville2 stops$245
Columbia
Columbia1 stop$293
Charlotte
Charlotte1 stop$211

Book Cheap Indianapolis to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Indianapolis to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Indianapolis to South Carolina

Sat, Aug 29 - Tue, Sep 1
Frontier Logo
7:33 pm - 8:01 am
IND
-
CLT
12h 28m
1 stop
Frontier Logo
8:56 am - 6:38 pm
CLT
-
IND
9h 42m
1 stop
$211Frontier
Tue, Sep 1 - Tue, Sep 15
Frontier Logo
7:33 pm - 4:58 pm
IND
-
CLT
21h 25m
1 stop
Frontier Logo
9:32 am - 10:25 am
CLT
-
IND
24h 53m
1 stop
$211Frontier
Mon, Aug 24 - Sun, Aug 30
Multiple Airlines Logo
7:00 am - 8:38 am
IND
-
CHS
25h 38m
1 stop
Multiple Airlines Logo
2:53 pm - 5:26 pm
CHS
-
IND
26h 33m
2 stops
$213Multiple Airlines
Mon, Aug 24 - Tue, Sep 1
Multiple Airlines Logo
7:00 am - 8:38 am
IND
-
CHS
25h 38m
1 stop
Multiple Airlines Logo
3:13 pm - 5:26 pm
CHS
-
IND
26h 13m
2 stops
$214Multiple Airlines
Tue, Aug 25 - Mon, Aug 31
American Airlines Logo
6:00 am - 11:24 am
IND
-
MYR
5h 24m
1 stop
American Airlines Logo
7:33 pm - 11:13 pm
MYR
-
IND
3h 40m
1 stop
$271American Airlines
Sat, Sep 19 - Sat, Sep 26
American Airlines Logo
3:06 pm - 9:08 pm
IND
-
MYR
6h 02m
1 stop
American Airlines Logo
12:10 pm - 6:07 pm
MYR
-
IND
5h 57m
1 stop
$271American Airlines
Sun, Sep 6 - Sat, Sep 12
Southwest Logo
4:25 pm - 8:30 pm
IND
-
MYR
4h 05m
1 stop
Southwest Logo
1:40 pm - 8:15 pm
MYR
-
IND
6h 35m
1 stop
$276Southwest
Thu, Sep 10 - Mon, Sep 14
Southwest Logo
5:25 am - 10:15 am
IND
-
MYR
4h 50m
1 stop
Southwest Logo
3:20 pm - 9:30 pm
MYR
-
IND
6h 10m
2 stops
$276Southwest
Thu, Aug 20 - Mon, Aug 24
Delta Logo
8:05 am - 1:55 pm
IND
-
GSP
5h 50m
1 stop
Delta Logo
5:20 pm - 9:23 pm
GSP
-
IND
4h 03m
1 stop
$279Delta
Thu, Aug 27 - Tue, Sep 1
Delta Logo
6:00 am - 10:20 am
IND
-
CHS
4h 20m
1 stop
Delta Logo
5:10 am - 10:30 am
CHS
-
IND
5h 20m
1 stop
$285Delta
Booking Insights

KAYAK's insights & trends for Indianapolis to South Carolina flights

Get data-powered insights and trends into flights from Indianapolis to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Indianapolis to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Indianapolis to South Carolina departing in August.

Flight prices are below average for this route right now.

Flights to South Carolina from Indianapolis usually cost between $282 and $441 in August.
The lowest price found in the past 5 days was $213 on Multiple Airlines (Aug 24-Aug 30).

What is the cheapest Indianapolis to South Carolina flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South Carolina from Indianapolis found in the last 5 days was to Myrtle Beach, at $70 round-trip. The most popular route is from Indianapolis (IND) to Myrtle Beach (MYR), and the cheapest round-trip airline ticket found on this route in the last 5 days was $70.

What is the cheapest time of day to fly to South Carolina?

The average price for all round-trip flights from Indianapolis to South Carolina depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to South Carolina is generally in the evening, when round-trip flights cost $117 on average. Morning departures are around 100% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the evening, which is peak travel time and where the average cost of a ticket is $117.

Can I save money by flying with a layover from Indianapolis to South Carolina?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $348, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Indianapolis to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Indianapolis to South Carolina is July, when tickets cost $197 (return) on average. On the other hand, the most expensive months are April and March, when the average cost of round-trip tickets is $446 and $426 respectively.

What’s the cheapest day of the week to fly from Indianapolis to South Carolina?

The average price of all round-trip flights from Indianapolis to South Carolina clicked on KAYAK for each day over the last 12 months.

When flying from Indianapolis to South Carolina, you should consider leaving on a Thursday and avoid Fridays if you are looking for the best rates. For your return to Indianapolis, you’ll find the best rates on Saturdays and the most expensive ones on Fridays.

How far in advance should I book a flight from Indianapolis to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Indianapolis to South Carolina, you should book around 3 weeks before departure, which saves you about 53% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 13 weeks before departure.

Good to know

Low season

January

Cheapest flight

$59
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 16% lower on average.
Flight from Indianapolis to Myrtle Beach

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Indianapolis to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Indianapolis to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Indianapolis to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Indianapolis to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Indianapolis to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Indianapolis to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Indianapolis to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Indianapolis to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Indianapolis to the following destinations at these prices or less: Charlotte $203 one-way - $380 round-trip

Reviews of the top 5 airlines serving from Indianapolis to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Indianapolis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Indianapolis to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4221 reviews
8.6Crew
7.5Entertainment
8.0Comfort
8.1Boarding
7.0Food
Airline reviews

The flight was delayed due to earlier issues at other airports. The crew was excellent & made it a good trip.

6.0 GoodJeremy, Aug 2026
STL - PHL
Read more Southwest reviews

The flight was delayed due to earlier issues at other airports. The crew was excellent & made it a good trip.

Boarding process of asking for volunteers to check bags goes against the system you had before with 2 bags checked free. This process is more of a guilt trip than a caring attitude toward the customer. In addition bag-size scrutiny has increased which also slows down the process of boarding. My wife said she will not fly on your airline again unless there is no other option.

Eveeyrime I fly they are begging for bags due to cabin overhead space. What they should so ia take the bags that are clearly too big to fit wheels first on their side. And those of us who give up the bag should really get their bags first. When boarding, nobody wants stupid jokes about how hot it is on board. Give us some cool air. Im usually sick from the heat by the time we take off.

No wifi, seems to be very common with Southwest currently. Everything else was normal.

Poor customer service, no accommodation for passengers when the flight was delayed over 5 hours.

Friendly crew kept coming by to make sure all was ok, provide additional refreshments, etc.

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Only one drink pass through the cabin for a 4 hour flight. Quite rough and bumpy landing.

Excellent! Only question is how we check in at exactly 24 hours in advance and end up at the end of the B boarding group

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

Extremely dosappoontined and frustrated. Refused entry to lounge in Detroit despite having Delta AMEX Reserve linked in MyDelta phone app as revommended and also having proof of account. No pillows were available for overnight flight to AMS and breakfast was not served in Delta Comfort.

All good on Delta's part. Passengers could be a little more courteous to each other.

The pilots were good. Disappointing when planes don't have electrical ports

Delta flight overall it was goodT!the crew could do more and the food could be better.

No complaints - left 20 minutes later than planned but still arrived on time.

Flight staff and all was fine. Food always sucks on planes so nothing new.

The flight crew were very helpful. The seats were very close together. There was barely room to sit without touching the person next to you.

I’m an EP on AA every year for more than a decade but this was a very pleasant and surprising experience. Clean and sizable plane for HOU to CHI. 5 row first class. And excellent food in first class the steak option was really good. Your flight attendants even better. Seat 5A

It was hot and not as comfortable as the flight to Chicago. Must have been a different plane that needs to be worked on or replaced.

My flight was delayed so bad i missed u it so i just said never mind

Wonderful flight! The crew was good, check-in was good and orderly and the flight was uneventful and good.

Gluten free snack options and meals that offer both gluten free and dairy free.

Not a bad flight but a long delay boarding and taking off due to the pilot not arriving on time.

Awful. No counter attendants. No dinner offered due to delays.

Flight was great. On time. Pleasant crew and responsible passengers. My only disappointment was that there was no coffee or tea offered. It was a short flight but a coffee would have been appreciated for what the price of tickets are now.

It was poor a four hour delay and no explanation for the delay. What’s a 35 dollars going to do. It also made me miss my car rental,

It was on time. Flight was comfortable. Staff was nice. It was the way a flight should always be.

The price was the only good thing about this flight. It was scary during takeoff when the plane tilted side to side. It made me feel very nervous as I have never had a take-off that unsmooth. There was no on-flight movie or music options and the only complimentary option was water. Other airlines offer trail mix or a caramel cookie and pop options as complimentary. This flight was a 2.5 hour flight. I understand for shorter flights not having options, but a flight 2 hours or longer should offer more complimentary options and in flight entertainment. Also the seats did not recline and for a longer flight reclining seats are a must for comfort.

A very pleasant flight but it would be greatly improved with wifi to help entertain kids

This is a no frills, get it done, efficient airline. The seat is a lawn chair. You better bring your own entertainment. If you want something other than water you need to pay for it. But they will get you to your destination quickly, on time, and then they will turn the flight around and go right back where they came from. Reliably. Couple times a week tops. If it fits into your schedule, you can’t get there cheaper or faster.

A three hour delay to board and then another hour on the tarmac because they couldn't get a tractor? Ugh.

It was canceled. The flight wasn’t rescheduled, everyone had to figure out their own new arrangements. They said we would get refunded our original fare and receive an additional $150. We received links for $100 only and they expired before we could activate them.

I didn't even take this flight. My plans changed and I couldn't get ahold of customer service and the website kept breaking down during the attempt to change the flight. I wound up taking another airline entirely and eating the cost.

We had a 4-hour delay due to a maintenance issue. We boarded, deplaned, then boarded again.

No frills, value airline. This trip was exactly what I expected. The flight was on time departing and arrived ahead of schedule. The crew was very efficient at getting people on and off the plane. I think the carry-on bag charges discouraged most people from bringing one, which led to quicker de-planing. I was careful to only bring a carefully packed personal item that was under the size limit. If you keep in mind that everything costs extra with this airline (including snacks, drinks, and printing boarding passes), and go into this with the right expectations, then all will be well. For the price difference, I would fly this airline again. My flight was only 1 hr. 20 minutes though. Much longer than that and comfort might drive me to another airline. The seats are very basic and don't recline at all.

IT issues created a mess had you change my flight and your system never changed it

The ground closures and flight delays were unwelcome. I think the captain did what he could to manage expectations for the delays, but the stress level increasing in the cabin was palpable with every announcement. It may be obvious to those who fly frequently, but if the ground is closed for us to get to a gate, it's also closed for connecting flights to leave. Other passengers were so stressed they were rude. A bit further explanation could have helped.

I’ve been on 8 flights with American Airlines in the last 2 months and 4 have been delayed.

Passenger was too loud for the entire flight crew not once ask them to tame it …. Many passengers are uncomfortable including having headaches

The Mario was so helpful and provided amazing customer service however l have being waiting for a callback for almost a week now and have not heard anything further after l informed them l wanted to change my date of traveling because of my hospital appointment even send them proof and l was unable to use manag your booking on their website is a bit frustrating and l would appreciate an update on My request as soon as possible. And have called them times without numbers no response

There is no room, no gluten free options, or any free internet/entertainment. You have to bring your own tablet or smartphone because there are no screens.

April was the flight attendant in first class and was the most pleasant, cordial and efficient person I have seen on a flight in years. Good example of the type of people AA should hire to increase customer satisfacdtion.

Excellent accommodating crew at gate and on board. Baggage claim and gate checking were flawless.

Delayed 6 times. Eventually rebooked and missed a whole day of my vacation. Hot mess

Unfriendly gate staff and significant delay once we were on the plane.

Everything you need to know for your flight from Indianapolis to South Carolina

Information on your arrival and departure airports