$56 Find Cheap Flights from Indianapolis to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 1/26. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Indianapolis to South Carolina.
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Indianapolis to South Carolina.
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Flight Deals

Cheap Flights from Indianapolis to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$137
Myrtle Beach
Myrtle Beach1 stop$166
Greenville
Greenville1 stop$243
Columbia
Columbia1 stop$220
Charlotte
Charlotte1 stop$133
Charleston
Charleston1 stop$137
Myrtle Beach
Myrtle Beach1 stop$166
Greenville
Greenville1 stop$243
Columbia
Columbia1 stop$220
Charlotte
Charlotte1 stop$133

Book Cheap Indianapolis to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Indianapolis to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Indianapolis to South Carolina

Tue, Feb 17 - Tue, Feb 24
Frontier Logo
9:13 pm - 7:58 am
IND
-
CLT
10h 45m1 stop
Frontier Logo
2:46 pm - 12:28 pm
CLT
-
IND
21h 42m1 stop
$133Frontier
Mon, Feb 2 - Mon, Feb 9
Multiple Airlines Logo
7:33 pm - 10:40 am
IND
-
CLT
15h 07m1 stop
Multiple Airlines Logo
5:24 pm - 10:48 pm
CLT
-
IND
29h 24m1 stop
$134Multiple Airlines
Mon, Jan 26 - Mon, Feb 2
Spirit Airlines Logo
5:10 am - 5:36 pm
IND
-
CHS
12h 26m1 stop
Spirit Airlines Logo
5:05 pm - 12:18 am
CHS
-
IND
7h 13m1 stop
$137Spirit Airlines
Sun, Jan 11 - Thu, Jan 15
Spirit Airlines Logo
6:55 am - 4:10 pm
IND
-
CHS
9h 15m1 stop
Spirit Airlines Logo
5:05 pm - 12:18 am
CHS
-
IND
7h 13m1 stop
$149Spirit Airlines
Sat, Jun 6 - Sat, Jun 13
Allegiant Air Logo
6:15 am - 8:00 am
IND
-
MYR
1h 45mnonstop
Allegiant Air Logo
8:50 am - 10:39 am
MYR
-
IND
1h 49mnonstop
$213Allegiant Air
Thu, Feb 12 - Tue, Feb 17
Delta Logo
1:44 pm - 6:05 pm
IND
-
CAE
4h 21m1 stop
Delta Logo
5:35 am - 10:31 am
CAE
-
IND
4h 56m1 stop
$220Delta
Sat, Jun 20 - Sat, Jun 27
Allegiant Air Logo
9:00 am - 10:46 am
IND
-
SAV
1h 46mnonstop
Allegiant Air Logo
5:03 pm - 6:55 pm
SAV
-
IND
1h 52mnonstop
$235Allegiant Air
Sun, Jan 18 - Sat, Jan 24
Delta Logo
6:00 am - 11:08 am
IND
-
GSP
5h 08m1 stop
Delta Logo
5:40 am - 9:39 am
GSP
-
IND
3h 59m1 stop
$243Delta
Sat, Feb 28 - Fri, Mar 6
American Airlines Logo
10:23 am - 2:36 pm
IND
-
AGS
4h 13m1 stop
American Airlines Logo
8:20 pm - 12:33 am
AGS
-
IND
4h 13m1 stop
$247American Airlines
Sat, Feb 28 - Fri, Mar 6
American Airlines Logo
10:47 am - 7:55 pm
IND
-
AGS
9h 08m2 stops
American Airlines Logo
8:20 pm - 12:33 am
AGS
-
IND
4h 13m1 stop
$252American Airlines
Booking Insights

KAYAK's insights & trends for Indianapolis to South Carolina flights

Get data-powered insights and trends into flights from Indianapolis to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Indianapolis to South Carolina flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South Carolina from Indianapolis found in the last 72 hours was to Myrtle Beach, at $147 round-trip. The most popular route is from Indianapolis (IND) to Charleston (CHS), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $202.

Can I save money by flying with a layover from Indianapolis to South Carolina?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $424, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Indianapolis to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Indianapolis to South Carolina is June, when tickets cost $164 (return) on average. On the other hand, the most expensive months are March and December, when the average cost of round-trip tickets is $412 and $411 respectively.

How far in advance should I book a flight from Indianapolis to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Indianapolis to South Carolina, you should book around 4 weeks before departure, which saves you about 58% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 22 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$56
Best time to beat the crowds with an average 4% drop in price.
Most popular time to fly and prices are also 16% lower on average.
Flight from Indianapolis to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Indianapolis to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Indianapolis to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Indianapolis to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Indianapolis to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Indianapolis to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Indianapolis to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Indianapolis to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Indianapolis to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally in the morning, when round-trip flights cost $141 on average. Morning departures are around 20% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally at night, which is peak travel time and where the average cost of a ticket is $326.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Indianapolis to the following destinations at these prices or less: Charlotte $190 one-way - $368 round-trip

Reviews of the top 5 airlines serving from Indianapolis to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Indianapolis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Indianapolis to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4250 reviews
7.5Entertainment
7.0Food
8.1Boarding
8.0Comfort
8.6Crew
Airline reviews

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

10.0 ExcellentAnonymous, Dec 2025
DAL - CHS
Read more Southwest reviews

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Flight was on time. Wi-fi was a little spotty/slow. Boarding and exit were efficient.

Okay, not wonderful. Short flight. Wi-fi didn't work properly. Stuck waiting for a gate to open upon arrival for 20 or so minutes.

They sent a notice that they were boarding an hour early. We had to leave the club and run to the gate. They said sorry, that came from corporate and was a mistake. They did not have enough seating because the flight before it had not taken off on time. They moved our gate and delayed it for an hour.

The boarding and seat assignment system no longer works for me, but I know it is being replaced. Otherwise, I am good with the overall experience.

The lead steward kept singing about "San Francisco" and hotel California---more annoying than humorous....needs work. Flight was smooth and on time.

Still a fan of open seating. Flight was on schedule and arrived on time. The 737 MAX is very comfortable.

Airline travel is always too cramped to really be pleasant, but the cabin crew on this flight did a pretty good job of making up for it by putting on some music during boarding and sprinkling a few funny remarks into the safety briefing and announcements, and just generally being friendly and helpful. It definitely reminded me of why I prefer the in-flight experience on Southwest!

No delays and arrived to destination 30 min early. Staff was super friendly.

San Diego airport is brand new, spacious, airy and very smooth checkin at SW baggage drop.

Did not realize internet screen was hidden between seats and no info printed!!!!

2 of the seats in row 31 the entertainment system was not working, and one seat the tray table did not go all the way down. Flight arrived early and departed on time which was great.

Very good flight crew and very nice people staff were incredible especially the gate agent

Waited at the usual crowded gate at DCA where one ends up standing up because there aren't enough seats.

The flight was delayed for about 2 hrs. Other than it, it was good.

Advertised fruit trays with cheese, but only snacks handed out!

The plant way delayed departing by 3 hours. It was an old airplane with broken seats and armrests. The bathroom made a hollering sound. A really crappy flight experience and travel day all around.

Flight delays both to Detroits and return flight . The flight to Detroit was associated with mechanical difficulty

I am extremely disappointed that delta internal pilot manuals now refer to the Gulf of Mexico as the “gulf of America”. You can bow down to the Orange turd on your own. I will never fly delta again

Wasn't a Delta issue I don't think, but seems there was a Delta flight at each of the 2 Dallas airports at the same exact time, both to Atlanta. I was evidently booked on the one at Love Airport, but the Carey transport shuttle took me to DFW instead and I ended up missing the flight by just a few minutes. Was able to book a Southwest flight from Love Airport, but was a big loss of time and an inconvenience.

We were 4+ hours delayed. AA is absolutely obnoxious. They just kept pushing back the time to the point where we did not get into Vegas until after midnight when we were supposed to arrive like 845pm.

My last flight on 25 Dec, it’s Christmas Day, everyone happy and very good mood. I really enjoy traveling with Americans Airlines from Miami to Minneapolis my home town after long flight from lhe to Doha then Miami. Thank you again to make my travels comfortable and relaxed. Best regards

The boarding process needs to be fixed. The zone don't work, especially when there is hardly anyone in zones 3, 4,and 5, leaving the majority of the passengers backed up in the aisle, especially because passengers seated near the front are blocking passengers who are seated in the rear of the plane. It would also help if the size of carry on bags was more strictly enforced.

WiFi didn’t work the entire flight. Very disappointing. Minimal food and options - sadly the state of current affairs. All other aspects of the flight were fine.

Great flight - friendly and attentive team! Seats in coach were comfy, but a little cramped - but that is the case with all airlines ;)

The boarding by groups is pointless. The first two groups worked fine, but almost Noone boarded in goups three thru five leaving the vast majority boarding when group six was called. It defeated the purpose of spreading out the crowd.

For whatever reason, the flight was not catered -we were told it would be a 45 minute delay waiting for catering - so no food. There were opened candy and peanuts in the seatback pocket. Flight landed early in DFW but due to the assigned gate not being available, we sat on the ground for 30 minutes waiting for the gate to open - making the flight actually arrive at the gate late.

The pilot greased the landing and the crew was fantastic.

I bought wifi and most of the flight could not even use it my apps would just spin. I couldn't even listen to music. super frustrating.

delayed due to weather. Could not communicate with family since the wifi was broken

It was fine. Nobody was outstandingly friendly but no one was rude and everything was smooth . The captain thanked us for flying but no one greeted me as I walked on the plane or as I exited which is the least they could do lol

Clean, friendly, roomy. But check-in from the phone link was terrible. Repeated attempts wouldn’t save at the final step. Just kept spinning! It was very frustrating. Finally, I used the app (vs website link) to check-in which worked very smoothly on the first attempt.

Check in on the web portal was cumbersome! After several attempts I finally got the boarding pass.

Excellent flight and even arrived 23 min early. No entertainment , or wi fi on board, but I downloaded a couple of movies beforehand which kept me entertained. Really like flying Allegiant airlines.

WE were delayed about an hour and never any communications from the employees working the gate. We also were moved to a total of three gates.

I love how they show love to their customers and care about them too.

I liked how when I got on board how fast we ended up taking off but what I truly disliked was how uncomfortable the seats were. There was truly never a time that I could ever get comfortable during both of my flights. The seats could get away during shorter flights but flights 3 hour plus makes it hard to enjoy.

The crew was great and the flight was very smooth. Can’t really judge food since I did not get any because it costs money. The seat was comfortable for what we bought. Thanks!

Crew was great. No entertainment and food and beverage was for purchase only, even water

It was canceled. The flight wasn’t rescheduled, everyone had to figure out their own new arrangements. They said we would get refunded our original fare and receive an additional $150. We received links for $100 only and they expired before we could activate them.

Delays due to a "power bank removal", no wifi, pilot said wrong arrival city, stewardess mumbled the word drinks as she rushed past, loud passengers with no enforcement of rules (blasting music out loud on their phones), screaming children

They cancelled my flight same day with no explanation why. They offered to rebook me but it would not be until 2 days later. I will never use them again.

Flight was cancelled with no help From spirit or kayak. Please refund asap

The flight was delayed by over an hour. The flight departure time and gate info kept changing several times. Very frustrating boarding experience and inconvenient for families with little children.

I waited for 4+ extra hours to even board when i was fighting off a cold. So i was sitting there in the airport with a fever and chills while spirit wasted my time. Then once on the plane we had at least an extra hour of taxiing before and after takeoff. Really poor airline, no amenities to speak of, and a lack of organization that will just ruin your experience.

Got to LAX at 3:20 am, the counter personnel did not start to check in bags till 3:40 am. I patiently waited at the priority check in line as they started to take people from the general line. After about 15 minutes of waiting, I approached the lady exactly in front of the priority line and asked her if they would be taking people from the priority line or if I would need to switch to waiting in the general line. She responded “yes”, I then asked her yes to what? And she yelled back at me loudly “I SAID YES!” Needless to say, I waited at the end of the line of the general line. I could have been told the priority line would not be called upon and could have queued in the general line ahead of many people that arrived to cue after I did

Very bad. Our flight was canceled and we need to rebook another flight which was in two hours after we’ve known about cancelation. It changed our plans. We had financial and other loses. Nobody did reimbursement to us.

A flight attendant was extremely friendly and offered to move me to a row that was less crowded

Awful!!! Spirit cancelled my flight just 4 hours before departure- with no alternative flights available. I ended up missing a huge family gathering because I wasn’t able to get out. Such An awful experience. And on top of that, all the buckle and dime-ing for bags. I will never book with Spirit EVER

Spirit has improved a lot since I flew with it in 2011. I give the airline a huge thumbs up!!

Everything you need to know for your flight from Indianapolis to South Carolina

Information on your arrival and departure airports