$64 Find Cheap Flights from Indianapolis to South Carolina

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to South Carolina

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Indianapolis to South Carolina.
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Indianapolis to South Carolina.
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Cheap Flights from Indianapolis to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$151
Myrtle Beach
Myrtle Beach1 stop$174
Greenville
Greenville1 stop$203
Columbia
Columbia1 stop$229
Charlotte
Charlotte1 stop$167
Charleston
Charleston1 stop$151
Myrtle Beach
Myrtle Beach1 stop$174
Greenville
Greenville1 stop$203
Columbia
Columbia1 stop$229
Charlotte
Charlotte1 stop$167

Book Cheap Indianapolis to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Indianapolis to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Indianapolis to South Carolina

Thu, Jan 15 - Mon, Jan 19
Spirit Airlines Logo
6:55 am - 4:10 pmIND-CHS
9h 15m1 stop
Spirit Airlines Logo
6:35 pm - 10:48 pmCHS-IND
28h 13m1 stop
$151Spirit Airlines
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Thu, Jan 8 - Sun, Jan 11
Spirit Airlines Logo
6:55 am - 4:10 pmIND-CHS
9h 15m1 stop
Spirit Airlines Logo
6:35 pm - 10:48 pmCHS-IND
28h 13m1 stop
$157Spirit Airlines
Find Deal
Sat, Dec 13 - Thu, Dec 18
Allegiant Air Logo
11:00 am - 10:44 amIND-GSP
23h 44m1 stop
Allegiant Air Logo
3:25 pm - 11:32 pmGSP-IND
8h 07m1 stop
$203Allegiant Air
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Fri, Jan 30 - Sun, Feb 1
Delta Logo
4:24 pm - 8:27 pmIND-CAE
4h 03m1 stop
Delta Logo
6:59 pm - 12:06 amCAE-IND
5h 07m1 stop
$229Delta
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Sat, Jan 17 - Wed, Jan 21
Delta Logo
4:20 pm - 8:31 pmIND-AGS
4h 11m1 stop
Delta Logo
5:45 am - 10:36 amAGS-IND
4h 51m1 stop
$247Delta
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Thu, Dec 11 - Sun, Dec 14
Allegiant Air Logo
1:40 pm - 2:10 pmIND-GSP
24h 30m1 stop
Allegiant Air Logo
11:34 am - 1:09 pmGSP-IND
25h 35m1 stop
$284Allegiant Air
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Thu, Dec 25 - Sat, Dec 27
American Airlines Logo
6:00 am - 11:17 amIND-CAE
5h 17m1 stop
American Airlines Logo
2:35 pm - 8:56 pmCAE-IND
6h 21m1 stop
$299American Airlines
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Fri, Jan 2 - Mon, Jan 5
American Airlines Logo
5:30 am - 10:47 amIND-GSP
5h 17m1 stop
American Airlines Logo
5:39 am - 12:34 pmGSP-IND
6h 55m1 stop
$304American Airlines
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Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
11:25 am - 7:24 pmIND-GSP
7h 59m2 stops
United Airlines Logo
10:45 am - 2:58 pmGSP-IND
4h 13m1 stop
$322United Airlines
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Sat, Feb 21 - Wed, Feb 25
United Airlines Logo
11:25 am - 7:24 pmIND-GSP
7h 59m2 stops
United Airlines Logo
2:51 pm - 9:59 pmGSP-IND
7h 08m2 stops
$327United Airlines
Find Deal
Booking Insights

KAYAK's insights & trends for Indianapolis to South Carolina flights

Get data-powered insights and trends into flights from Indianapolis to South Carolina to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest Indianapolis to South Carolina flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South Carolina from Indianapolis found in the last 72 hours was to Myrtle Beach, at $127 round-trip. The most popular route is from Indianapolis (IND) to Myrtle Beach (MYR), and the cheapest round-trip airline ticket found on this route in the last 72 hours was $127.

Can I save money by flying with a layover from Indianapolis to South Carolina?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $315, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Indianapolis to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Indianapolis to South Carolina is June, when tickets cost $164 (return) on average. On the other hand, the most expensive months are March and December, when the average cost of round-trip tickets is $404 and $389 respectively.

What’s the cheapest day of the week to fly from Indianapolis to South Carolina?

The average price of all round-trip flights from Indianapolis to South Carolina clicked on KAYAK for each day over the last 12 months.

When flying from Indianapolis to South Carolina, you should consider leaving on a Wednesday and avoid Sundays if you are looking for the best rates. For your return to Indianapolis, you’ll find the best rates on Fridays and the most expensive ones on Tuesdays.

How far in advance should I book a flight from Indianapolis to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Indianapolis to South Carolina, you should book around 4 weeks before departure, which saves you about 55% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 22 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$57
Best time to beat the crowds but there is an average 9% increase in price.
Most popular time to fly and prices are also 16% lower on average.
Flight from Indianapolis to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Indianapolis to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Indianapolis to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Indianapolis to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Indianapolis to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Indianapolis to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Indianapolis to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Indianapolis to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Indianapolis to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • What is the cheapest time of day to fly to South Carolina?

    The cheapest time of day to fly to South Carolina is generally in the morning, when round-trip flights cost $141 on average. Morning departures are around 20% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally at night, which is peak travel time and where the average cost of a ticket is $326.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Indianapolis to the following destinations at these prices or less: Charlotte $173 one-way - $337 round-trip

Reviews of the top 5 airlines serving from Indianapolis to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Indianapolis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Indianapolis to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4255 reviews
7.5Entertainment
8.6Crew
7.0Food
8.1Boarding
8.0Comfort
Airline reviews

No delays and arrived to destination 30 min early. Staff was super friendly.

10.0 ExcellentIlevba, Nov 2025DCA - DAL
Read more Southwest reviews

No delays and arrived to destination 30 min early. Staff was super friendly.

San Diego airport is brand new, spacious, airy and very smooth checkin at SW baggage drop.

It was rough. The staff was unprofessional, the choice of on board drinks terrible, it was cramped in space at every airport, they always ran out of overhead bin space so they pressured people to check bags for free or we couldn’t leave on the plane— so I did check my bag to help, and they nearly lost my bag. My bag did not arrive on the luggage belt, another man on my flight and I had to waste our time going to the baggage office to search for our bags. I would only fly southwest again if it was my last choice. Also, my flights were consistently delayed over and over again— at one point they straight up told us we were waiting for the pilot to arrive.

Crew could have been friendlier, maybe I'm spoiled by SW crews. In flight wifi was good. Would be nice to have more food offerings on a 4 plus hour flight

Had to get off plane from prior flight even though I had to reboard same plane to continue to my final destination.

Everything a cheap airline should be at normal airline rates.

Plane crashed into a bus or some other vehicle on the ground while pulling out of the gate. No injuries, but wing tip was damaged and returned to gate for “maintenance issues” and we departed 5 hours later because the plane went out of service and new plane was flown in from a nearby airport, Midway.

Ever since Southwest starting charging for bags, passengers don't want to pay to check their bags, so the gate agents have to beg people to check their roller bags now because there's "not enough space". This was a terrible business move by Southwest.

Full cans of soda would be nice. A choice between two snacks would be appreciated.

Tried watching free movie and it kept freezing so I couldn’t finish.

Very smooth, on-time, and pleasantly uneventful flight. The team at the gate and on board were professional and genuinely courteous. The pilot kept us well updated throughout, and both takeoff and landing were steady and enjoyable without any drama. Just a good, solid flight. Thank you! 💗

Staff was exceptional! Everyone was kind, professional and friendly making the trip very pleasant. Thank you!

No lunch on a x-country flight scheduled for 10:50 am departure, arrived 5+ hrs later. That requires a black box label before you pay for the tickets. Worst, when I checked in online, it's specifically said that lunch was served on his flight for economy Plus passengers.

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

First, Delta needs more flights to/from Miami. Second, a 1000pm leaving at 1230pm is unacceptable from their biggest airport world hub. Another aircraft could have been used such as the aircraft scheduled to be used in the morning for that exact same route. Yes, I did get me there but the lack of sleep the next day didn't help me enjoy my entire trip since I was busy with activities during the weekend. This can be and is expected from Spirit (going bankrupt) and Frontier (despite they're nickel and dimers). But from Delta's World Hub? That's totally unacceptable!

This flight was straightforward and without difficulty. Service was OK, but I continue to be underwhelmed by level of attention given to Sky Priority passengers.

It would’ve been nice for all that money to have a more substantial snack for free. I remember once upon a time getting a very nice turkey sandwich with Swiss cheese on whole wheat bread for no charge along with a drink. I guess those days are gone. it’s a little insulting being given a cookie or a bag of baked chips Going forward I’ll just bring my own.

Our flight from SFO to MSP was right on time on 11/15/2025. No delays. As we approached MSP at about 8 pm, we circled in the air until 8:40 pm so I don't call that efficient for MSP. I think the captain should announce the delay and why. (as if we all don't know that we are just circling around the area, slowing down, speeding up, slowing down.) Thank you. Marilyn Fischer

Service in business class was not impressive. I ordered coffee with dinner and then watched other people get 2 refills before I got my 1 cup of coffee, and only after I pressed the attendant button overhead. Furthermore, the seats in the forward cabin need maintenance on this 737-800: the upholstery is detaching from the seat frame, at least on the backs of seats 1C, 1D.

The ticket agents in West Palm Beach on Friday afternoon Nov. 7th were incredible in getting us on an earlier plane to Atlanta during the government shutdown. Had the taken our original flight we would have missed our connection. She did this on her own, We didn't even have to ask, and she did it all with a smile and showing genuine concern that we would be taken care of. We are very grateful and thankful. We fly often, and now we will be sure to fly Delta.

I like that the crew kept us informed but we moved back and forth from gate to gate before the aircraft arrived.

The flight was delayed multiple times, again no fault of American but again the extra cost, for everything makes it feel like a cheap airline! Especially when flights are outrageously expensive already

Horrible. Both legs of my flight were delayed more than 6 hours. No compensation, no screens on the plane, and the plane was not clean.

I had a positive experience on American. I'm blind and traveling with a guide dog and the flight attendants were so kind, friendly, and helpful towards us. They checked in on us during the flight and they made us feel comfortable and welcomed. There was an hour delay before depature, but overall the flight was a smooth ride. I appreciate that there were no issues on this long flight back home.

We were told the flight was delayed 5 times, then it was moved to the next day.

More choices on snacks. Built-in video screen to enjoy entertainment choices.

we landed at cmh ten minutes early but had to sit on tarmac for twenty minutes because a plane was at our gate despite the fact that 3 other gates were open.

The experience with American Airlines was good, although the Philippines Airlines flight was much better (better seats, better food, better entertainment options, overall better). Again, the MIA to LAX flight was fine, but nothing in comparison to the comfort and accommodations of the Philippines Airlines flight from LAX to MNL.

I have a gluten allergy so did have any food

I have a gluten allergy so didn't have any food

Excellent flight and even arrived 23 min early. No entertainment , or wi fi on board, but I downloaded a couple of movies beforehand which kept me entertained. Really like flying Allegiant airlines.

WE were delayed about an hour and never any communications from the employees working the gate. We also were moved to a total of three gates.

I love how they show love to their customers and care about them too.

I liked how when I got on board how fast we ended up taking off but what I truly disliked was how uncomfortable the seats were. There was truly never a time that I could ever get comfortable during both of my flights. The seats could get away during shorter flights but flights 3 hour plus makes it hard to enjoy.

The crew was great and the flight was very smooth. Can’t really judge food since I did not get any because it costs money. The seat was comfortable for what we bought. Thanks!

Crew was great. No entertainment and food and beverage was for purchase only, even water

It was canceled. The flight wasn’t rescheduled, everyone had to figure out their own new arrangements. They said we would get refunded our original fare and receive an additional $150. We received links for $100 only and they expired before we could activate them.

The plane had originated in Las Vegas at 6:30 in the morning and flew to Moline where we boarded. The flight left around 12:30 PM and there were no boxed snacks available and many of the alcoholic beverages were unavailable. I would find it hard to believe that that many of the passengers coming from Las Vegas at 6:30 in the morning, drank and ate that much of the items. I can only come to the conclusion that someone failed to stock the plane for the round-trip. This is a huge revenue failure for the airline and disappointment for the passengers. The flight crew did not seem happy to be there and did not engage with passengers. Allegiant you can do better.

They did not let my husband on the plane with our service animal at the last minute. Do NOT fly this airline with a service animal!

Tight! Seats are not designed for those of us who wear extra-large clothes.

I didn't eat, so I can't rate the food. Delayed set off was beyond

No free snacks or drinks. Freezing. Uncomfortable. No plugs or entertainment. If you fly to LA the make you change terminals with a slow bus. Awful trip that took forever. Terrible airline- maybe the worst I’ve ever flown.

I hope you continue to be one of the great company

Crew are always very angry and dismissive like they seem they are being forced to work. In addition, there was a long line for the bathrooms, and only one was allowed to be used. No reason was given for only one bathroom being available; apparently, the stewardess was more interested in using the jumpseat instead of allowing the customers to use the bathroom.

Very positive in both directions. Safe travels, nice staff, lost and found in fact found my phone under my chair! I was out of cash after my NYC trip otherwise I would've offered a reward for helping my day out immensly! Thanks you so much Spirit staff!

I stopped flying spirit as much because they are crooks and thieves. It's not like other airlines where you can at least get credits they just take your money.

Flight was on time. Friendly crew. Gate agents in the other hand were very unfriendly.

Uncomfortable seats and tiny tray table. Expensive snacks. Flight was on time and crew was pleasant but take me back to Southwest!

Boarding and unboarding processes were pretty smooth. I gave a low score for Boarding because of how my flight was missing from all the boards at the airport, and when I checked the flight status on the Spirit website, it said it would be departing from Terminal E, gate D15. There are no "D" gates in terminal E.

Speaker airport didn't work well, so we couldn't hear the boarding call but the plane was on time leaving and on time arriving took a while for them to open the door and there was a non-disruptive guy who was inebriated a few rows ahead of us. Overall the flight was good and we appreciate the on-time-ness

Everything you need to know for your flight from Indianapolis to South Carolina

Information on your arrival and departure airports