$84 Find Cheap Flights from Indianapolis to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from Indianapolis to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charleston1 stop$192
Myrtle Beach
Myrtle Beach1 stop$250
Greenville
Greenville1 stop$244
Columbia
Columbia1 stop$296
Charlotte
Charlotte1 stop$176
Charleston
Charleston1 stop$192
Myrtle Beach
Myrtle Beach1 stop$250
Greenville
Greenville1 stop$244
Columbia
Columbia1 stop$296
Charlotte
Charlotte1 stop$176

Book Cheap Indianapolis to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Indianapolis to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Indianapolis to South Carolina

Wed, Oct 28 - Mon, Nov 2
Frontier Logo
10:44 am - 4:38 pmIND  Indianapolis-CLT Charlotte Douglas
5h 54m1 stop Orlando
Frontier Logo
10:02 pm - 9:49 amCLT  Charlotte Douglas-IND Indianapolis
11h 47m1 stop Orlando
$176Frontier
Wed, Oct 21 - Mon, Oct 26
Frontier Logo
6:41 pm - 12:38 pmIND  Indianapolis-CLT Charlotte Douglas
17h 57m1 stop Orlando
Frontier Logo
10:02 pm - 9:49 amCLT  Charlotte Douglas-IND Indianapolis
11h 47m1 stop Orlando
$178Frontier
Tue, Oct 27 - Tue, Nov 10
Multiple Airlines Logo
10:44 am - 8:38 amIND  Indianapolis-CHS Charleston
21h 54m1 stop Orlando
Multiple Airlines Logo
3:00 pm - 9:49 amCHS  Charleston-IND Indianapolis
18h 49m1 stop Orlando
$192Multiple Airlines
Mon, Sep 14 - Thu, Sep 17
Multiple Airlines Logo
9:20 pm - 8:38 amIND  Indianapolis-CHS Charleston
11h 18m1 stop Orlando
Multiple Airlines Logo
2:13 pm - 6:53 pmCHS  Charleston-IND Indianapolis
28h 40m2 stops Orlando Atlanta Hartsfield-Jackson
$198Multiple Airlines
Thu, Sep 24 - Thu, Oct 1
Allegiant Air Logo
8:30 am - 1:28 pmIND  Indianapolis-GSP Greenville
28h 58m1 stop Fort Lauderdale
Allegiant Air Logo
8:07 pm - 8:18 amGSP  Greenville-IND Indianapolis
12h 11m1 stop Sarasota Bradenton Intl
$253Allegiant Air
Tue, Sep 1 - Thu, Sep 3
Southwest Logo
12:15 pm - 7:00 pmIND  Indianapolis-CLT Charlotte Douglas
6h 45m1 stop Baltimore/Washington
Southwest Logo
1:05 pm - 10:40 pmCLT  Charlotte Douglas-IND Indianapolis
9h 35m2 stops Baltimore/Washington Chicago Midway
$267Southwest
Sat, Sep 5 - Sat, Sep 12
American Airlines Logo
3:20 pm - 9:26 pmIND  Indianapolis-MYR Myrtle Beach Intl
6h 06m1 stop Charlotte Douglas
American Airlines Logo
5:45 pm - 11:41 pmMYR  Myrtle Beach Intl-IND Indianapolis
5h 56m1 stop Charlotte Douglas
$276American Airlines
Tue, Sep 1 - Thu, Sep 3
Southwest Logo
7:40 am - 11:55 amIND  Indianapolis-CLT Charlotte Douglas
4h 15m1 stop Chicago Midway
Southwest Logo
8:10 am - 12:10 pmCLT  Charlotte Douglas-IND Indianapolis
4h 00m1 stop Chicago Midway
$277Southwest
Sat, Sep 5 - Sun, Sep 6
United Airlines Logo
3:42 pm - 11:59 pmIND  Indianapolis-CHS Charleston
8h 17m1 stop Newark
United Airlines Logo
11:40 am - 4:48 pmCHS  Charleston-IND Indianapolis
5h 08m1 stop Chicago O'Hare Intl
$280United Airlines
Fri, Oct 23 - Mon, Oct 26
American Airlines Logo
6:04 am - 11:38 amIND  Indianapolis-MYR Myrtle Beach Intl
5h 34m1 stop Washington, D.C. Reagan-National
American Airlines Logo
8:12 pm - 12:37 amMYR  Myrtle Beach Intl-IND Indianapolis
4h 25m1 stop Charlotte Douglas
$281American Airlines
Booking Insights

KAYAK's insights & trends for Indianapolis to South Carolina flights

Get data-powered insights and trends into flights from Indianapolis to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Indianapolis to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Indianapolis to South Carolina departing in October.

Flight prices are below average for this route right now.

Flights to South Carolina from Indianapolis usually cost between $292 and $640 in October.
The lowest price found in the past 5 days was $192 on Multiple Airlines (Oct 27-Nov 10).

What is the cheapest Indianapolis to South Carolina flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South Carolina from Indianapolis found in the last 5 days was to Myrtle Beach, at $70 round-trip. The most popular route is from Indianapolis (IND) to Myrtle Beach (MYR), and the cheapest round-trip airline ticket found on this route in the last 5 days was $70.

What is the cheapest time of day to fly to South Carolina?

The average price for all round-trip flights from Indianapolis to South Carolina depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to South Carolina is generally in the evening, when round-trip flights cost $117 on average. Morning departures are around 100% cheaper than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the evening, which is peak travel time and where the average cost of a ticket is $117.

Can I save money by flying with a layover from Indianapolis to South Carolina?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $348, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Indianapolis to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Indianapolis to South Carolina is July, when tickets cost $184 (return) on average. On the other hand, the most expensive months are April and March, when the average cost of round-trip tickets is $446 and $423 respectively.

What’s the cheapest day of the week to fly from Indianapolis to South Carolina?

The average price of all round-trip flights from Indianapolis to South Carolina clicked on KAYAK for each day over the last 12 months.

When flying from Indianapolis to South Carolina, you should consider leaving on a Thursday and avoid Fridays if you are looking for the best rates. For your return to Indianapolis, you’ll find the best rates on Fridays and the most expensive ones on Saturdays.

How far in advance should I book a flight from Indianapolis to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Indianapolis to South Carolina, you should book around 3 weeks before departure, which saves you about 53% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 21 weeks before departure.

Good to know

Low season

January

Cheapest flight

$84
Best time to beat the crowds with an average 6% drop in price.
Most popular time to fly and prices are also 17% lower on average.
Flight from Indianapolis to Charlotte

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Indianapolis to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Indianapolis to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Indianapolis to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Indianapolis to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Indianapolis to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Indianapolis to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Indianapolis to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Indianapolis to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Indianapolis to the following destinations at these prices or less: Charlotte $189 one-way - $376 round-trip

Reviews of the top 5 airlines serving from Indianapolis to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Indianapolis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Indianapolis to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
SouthwestOverall score based on 4216 reviews
7.5Entertainment
7.0Food
8.1Boarding
8.0Comfort
8.6Crew
Airline reviews

Just crazy with times being pushed and pushed and pushed and gate crew at Philly super rude and unprofessional with many under stress with delays.

2.0 MediocreHans, Aug 2026
Read more Southwest reviews

Just crazy with times being pushed and pushed and pushed and gate crew at Philly super rude and unprofessional with many under stress with delays.

I liked the new boarding process. I thought the buyup options (legroom, early boarding) to be easy to request and reasonably priced. All the Southwest team from gate to in-flight were so nice.

Flight time kept changing and so did the gate. It was very frustrating

Exceptional. The gate crew responded quickly and got me onto this earlier flight as the final passenger, saving me more than four hours of wait time for my reserved flight.

The flight was delayed due to earlier issues at other airports. The crew was excellent & made it a good trip.

Boarding process of asking for volunteers to check bags goes against the system you had before with 2 bags checked free. This process is more of a guilt trip than a caring attitude toward the customer. In addition bag-size scrutiny has increased which also slows down the process of boarding. My wife said she will not fly on your airline again unless there is no other option.

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Only one drink pass through the cabin for a 4 hour flight. Quite rough and bumpy landing.

Excellent! Only question is how we check in at exactly 24 hours in advance and end up at the end of the B boarding group

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

Extremely dosappoontined and frustrated. Refused entry to lounge in Detroit despite having Delta AMEX Reserve linked in MyDelta phone app as revommended and also having proof of account. No pillows were available for overnight flight to AMS and breakfast was not served in Delta Comfort.

All good on Delta's part. Passengers could be a little more courteous to each other.

The pilots were good. Disappointing when planes don't have electrical ports

Delta flight overall it was goodT!the crew could do more and the food could be better.

No complaints - left 20 minutes later than planned but still arrived on time.

Like the fact that the boarding was expedited. But the delay and chaos around the onboarding was not appreciated.

Flight was 2.5 late. Maybe not United’s fault but late none the less. We were late as well on the first leg. WiFi quit working with an hour left.

Old 757 with poor entertainment system. United no longer partners with United for free text and email. O'Hara an absolute disaster! Limited gates clauses two hour delay. Unfortunately this appears to be the norm.

The flight to America was freezing. The overnight flight back to the UK was boiling hot and the cabin stank of toilet or occasionally perfume, even though I was several rows back from either bathroom. Food was tiny portions. Two small pieces of tough and dry beef in random gravy with pretend mashed potato raking up most of it. Very little veg. Salad was ok. Wooden cutlery broke within minutes of using. Lots of old films for entertainment. Some new ones. Generally a bit rubbish.

It was a good experience, unfortunately my checked baggages were come late and not arrived on time.

Very stressful to locate United Airline boarding area, delayed flight, changing boarding area again to another location with all tiredness 😩. But flying was fine.

Flight staff and all was fine. Food always sucks on planes so nothing new.

Not a bad flight but a long delay boarding and taking off due to the pilot not arriving on time.

Awful. No counter attendants. No dinner offered due to delays.

Flight was great. On time. Pleasant crew and responsible passengers. My only disappointment was that there was no coffee or tea offered. It was a short flight but a coffee would have been appreciated for what the price of tickets are now.

It was poor a four hour delay and no explanation for the delay. What’s a 35 dollars going to do. It also made me miss my car rental,

It was on time. Flight was comfortable. Staff was nice. It was the way a flight should always be.

The price was the only good thing about this flight. It was scary during takeoff when the plane tilted side to side. It made me feel very nervous as I have never had a take-off that unsmooth. There was no on-flight movie or music options and the only complimentary option was water. Other airlines offer trail mix or a caramel cookie and pop options as complimentary. This flight was a 2.5 hour flight. I understand for shorter flights not having options, but a flight 2 hours or longer should offer more complimentary options and in flight entertainment. Also the seats did not recline and for a longer flight reclining seats are a must for comfort.

A very pleasant flight but it would be greatly improved with wifi to help entertain kids

This is a no frills, get it done, efficient airline. The seat is a lawn chair. You better bring your own entertainment. If you want something other than water you need to pay for it. But they will get you to your destination quickly, on time, and then they will turn the flight around and go right back where they came from. Reliably. Couple times a week tops. If it fits into your schedule, you can’t get there cheaper or faster.

A three hour delay to board and then another hour on the tarmac because they couldn't get a tractor? Ugh.

It was canceled. The flight wasn’t rescheduled, everyone had to figure out their own new arrangements. They said we would get refunded our original fare and receive an additional $150. We received links for $100 only and they expired before we could activate them.

I didn't even take this flight. My plans changed and I couldn't get ahold of customer service and the website kept breaking down during the attempt to change the flight. I wound up taking another airline entirely and eating the cost.

We had a 4-hour delay due to a maintenance issue. We boarded, deplaned, then boarded again.

No frills, value airline. This trip was exactly what I expected. The flight was on time departing and arrived ahead of schedule. The crew was very efficient at getting people on and off the plane. I think the carry-on bag charges discouraged most people from bringing one, which led to quicker de-planing. I was careful to only bring a carefully packed personal item that was under the size limit. If you keep in mind that everything costs extra with this airline (including snacks, drinks, and printing boarding passes), and go into this with the right expectations, then all will be well. For the price difference, I would fly this airline again. My flight was only 1 hr. 20 minutes though. Much longer than that and comfort might drive me to another airline. The seats are very basic and don't recline at all.

IT issues created a mess had you change my flight and your system never changed it

The ground closures and flight delays were unwelcome. I think the captain did what he could to manage expectations for the delays, but the stress level increasing in the cabin was palpable with every announcement. It may be obvious to those who fly frequently, but if the ground is closed for us to get to a gate, it's also closed for connecting flights to leave. Other passengers were so stressed they were rude. A bit further explanation could have helped.

I’ve been on 8 flights with American Airlines in the last 2 months and 4 have been delayed.

Passenger was too loud for the entire flight crew not once ask them to tame it …. Many passengers are uncomfortable including having headaches

The Mario was so helpful and provided amazing customer service however l have being waiting for a callback for almost a week now and have not heard anything further after l informed them l wanted to change my date of traveling because of my hospital appointment even send them proof and l was unable to use manag your booking on their website is a bit frustrating and l would appreciate an update on My request as soon as possible. And have called them times without numbers no response

There is no room, no gluten free options, or any free internet/entertainment. You have to bring your own tablet or smartphone because there are no screens.

April was the flight attendant in first class and was the most pleasant, cordial and efficient person I have seen on a flight in years. Good example of the type of people AA should hire to increase customer satisfacdtion.

Excellent accommodating crew at gate and on board. Baggage claim and gate checking were flawless.

Delayed 6 times. Eventually rebooked and missed a whole day of my vacation. Hot mess

Unfriendly gate staff and significant delay once we were on the plane.

Everything you need to know for your flight from Indianapolis to South Carolina

Information on your arrival and departure airports