$45 Find Cheap Flights from Indianapolis to South Carolina - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Indianapolis to South Carolina departing on 8/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
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Cheap Flights from Indianapolis to South Carolina

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours
Charleston
Charlestonnonstop$83
Myrtle Beach
Myrtle Beachnonstop$70
Greenville
Greenville1 stop$227
Columbia
Columbia1 stop$276
Charlotte
Charlotte1 stop$199
Charleston
Charlestonnonstop$83
Myrtle Beach
Myrtle Beachnonstop$70
Greenville
Greenville1 stop$227
Columbia
Columbia1 stop$276
Charlotte
Charlotte1 stop$199

Book Cheap Indianapolis to South Carolina Plane Tickets

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Indianapolis to South Carolina that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Indianapolis to South Carolina

Sat, Aug 1 - Sat, Aug 8
Allegiant Air Logo
6:10 am - 7:56 am
IND
-
MYR
1h 46mnonstop
Allegiant Air Logo
8:51 am - 10:45 am
MYR
-
IND
1h 54mnonstop
$70Allegiant Air
Sat, Aug 1 - Sat, Aug 8
Allegiant Air Logo
6:10 am - 7:56 am
IND
-
MYR
1h 46mnonstop
Allegiant Air Logo
8:51 am - 10:45 am
MYR
-
IND
1h 54mnonstop
$74Allegiant Air
Fri, Sep 25 - Sat, Sep 26
Delta Logo
2:30 pm - 7:52 pm
IND
-
GSP
5h 22m
1 stop
Delta Logo
9:00 am - 1:02 pm
GSP
-
IND
4h 02m
1 stop
$227Delta
Fri, Aug 7 - Fri, Aug 14
Southwest Logo
3:30 pm - 8:15 pm
IND
-
GSP
4h 45m
1 stop
Southwest Logo
7:00 am - 2:50 pm
GSP
-
IND
7h 50m
2 stops
$232Southwest
Thu, Aug 6 - Mon, Aug 10
Southwest Logo
5:20 pm - 9:35 pm
IND
-
GSP
4h 15m
1 stop
Southwest Logo
7:00 am - 2:50 pm
GSP
-
IND
7h 50m
2 stops
$234Southwest
Mon, Sep 14 - Fri, Sep 18
United Airlines Logo
4:25 pm - 9:19 pm
IND
-
SAV
4h 54m
1 stop
United Airlines Logo
4:23 pm - 11:40 pm
SAV
-
IND
7h 17m
1 stop
$251United Airlines
Tue, Aug 18 - Sat, Aug 22
United Airlines Logo
7:00 am - 2:38 pm
IND
-
SAV
7h 38m
2 stops
United Airlines Logo
4:59 pm - 10:00 pm
SAV
-
IND
5h 01m
1 stop
$256United Airlines
Sat, Aug 8 - Sun, Aug 9
American Airlines Logo
6:00 am - 9:34 am
IND
-
CAE
3h 34m
1 stop
American Airlines Logo
8:34 pm - 12:20 am
CAE
-
IND
3h 46m
1 stop
$276American Airlines
Wed, Aug 12 - Mon, Aug 17
Delta Logo
1:41 pm - 8:10 pm
IND
-
CAE
6h 29m
1 stop
Delta Logo
7:47 pm - 12:27 am
CAE
-
IND
4h 40m
1 stop
$283Delta
Thu, Aug 27 - Sun, Aug 30
American Airlines Logo
6:00 am - 9:34 am
IND
-
CAE
3h 34m
1 stop
American Airlines Logo
5:00 am - 9:06 am
CAE
-
IND
4h 06m
1 stop
$303American Airlines
Booking Insights

KAYAK's insights & trends for Indianapolis to South Carolina flights

Get data-powered insights and trends into flights from Indianapolis to South Carolina to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Indianapolis to South Carolina?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Indianapolis to South Carolina departing in July.

What is the cheapest Indianapolis to South Carolina flight route?

Data is based on round-trip flight searches on KAYAK over the past month.

The cheapest ticket to South Carolina from Indianapolis found in the last 5 days was to Charleston, at $79 round-trip. The most popular route is from Indianapolis (IND) to Charleston (CHS), and the cheapest round-trip airline ticket found on this route in the last 5 days was $79.

What is the cheapest time of day to fly to South Carolina?

The average price for all round-trip flights from Indianapolis to South Carolina depending on the time of departure, clicked by users on KAYAK in the last 2 weeks.

The cheapest time of day to fly to South Carolina is generally in the evening, when round-trip flights cost $113 on average. Morning departures are around 60% more expensive than evening flights, on average. The most expensive time of day to fly to South Carolina is generally in the morning, which is peak travel time and where the average cost of a ticket is $181.

Can I save money by flying with a layover from Indianapolis to South Carolina?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $315, prices are generally cheapest when you fly direct.

What is the cheapest month to fly from Indianapolis to South Carolina?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Indianapolis to South Carolina is July, when tickets cost $45 (return) on average. On the other hand, the most expensive months are April and January, when the average cost of round-trip tickets is $270 and $185 respectively.

How far in advance should I book a flight from Indianapolis to South Carolina?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Indianapolis to South Carolina, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Indianapolis to South Carolina, you should book around 4 weeks before departure, which saves you about 62% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 7 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$45
Best time to beat the crowds with an average 5% drop in price.
Most popular time to fly and prices are also 16% lower on average.
Flight from Indianapolis to Charleston

FAQs - booking South Carolina flights

  • How does KAYAK find such low prices on flights from Indianapolis to South Carolina?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Indianapolis to South Carolina.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Indianapolis to South Carolina?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight from Indianapolis to South Carolina is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Indianapolis to South Carolina?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly from Indianapolis to South Carolina with an airline and back with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Indianapolis to South Carolina?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying from Indianapolis to South Carolina up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

  • How many flights are there between Indianapolis and South Carolina per day?

    There is a maximum of 1 nonstop flight a day that takes off from Indianapolis and lands in South Carolina, with an average flight time of 1h 50m. The most common departure time is 6:00 pm and most flights take off in the evening. Each week, there are 3 flights.

Top tips for finding cheap flights to South Carolina

  • Looking for a cheap flight? 25% of our users found tickets from Indianapolis to the following destinations at these prices or less: Charlotte $178 one-way - $366 round-trip

Reviews of the top 5 airlines serving from Indianapolis to South Carolina

 
See real verified KAYAK customer reviews for airlines flying from Indianapolis to South Carolina. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Indianapolis to South Carolina? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4250 reviews
7.5Entertainment
7.0Food
8.6Crew
8.0Comfort
8.1Boarding
Airline reviews

Overall good, just screaming kids in the area the whole flight.

8.0 ExcellentAnonymous, Jul 2026
MDW - MHT
Read more Southwest reviews

Overall good, just screaming kids in the area the whole flight.

My experience will Southwest was good. I wish there was more entertainment and the boarding process was slow at time but other than that my experience was great definitely will be flying with SouthWest again.

Flight was delayed by 2 hours, meaning that a flight to Dwnver which should have arrived at 11pm came into the airport at 1 am. Made for a very long day.

I think Southwest is the number one airline that anyone can fly I have flown for the first time Frontier and what a joke and their customer service United was a very strange experience I'm only sticking to Southwest from here on out for sure

Great job! My family doesnt fly often but we felt safe 100%

Great job Southwest! My family doesn't fly often but we felt safe the whole time.

I'm glad it wasn't only 75% full because I could get a good seat

Check-in, Boarding and flight were smooth. All the employees and crew was very nice and funny. They gave the kids crayons and workbooks to keep them occupied which was a big win. I’ve flown Southwest many times and that’s the first time I’ve seen that and it is a great addition.

Only one drink pass through the cabin for a 4 hour flight. Quite rough and bumpy landing.

Excellent! Only question is how we check in at exactly 24 hours in advance and end up at the end of the B boarding group

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

For some reason, TSA Atlanta didn’t have my bag on the flight on time and they don’t have to provide Delta a reason for that.

I am still at the Airport! Delayed Delayed and Delyaed

The landing was the worst I’ve experienced with a flight.

It was last minute due to weather - considering - it was amazing! Good smiles, friendly staff and they were making sure we knew what was going on when and where.

Extremely dosappoontined and frustrated. Refused entry to lounge in Detroit despite having Delta AMEX Reserve linked in MyDelta phone app as revommended and also having proof of account. No pillows were available for overnight flight to AMS and breakfast was not served in Delta Comfort.

All good on Delta's part. Passengers could be a little more courteous to each other.

The pilots were good. Disappointing when planes don't have electrical ports

Delta flight overall it was goodT!the crew could do more and the food could be better.

No complaints - left 20 minutes later than planned but still arrived on time.

It was a short, comfortable flight. It did leave an hour late due to the pilot having to be replaced (family emergency) but that didn’t inconvenience myself & my friend. The situation was explained, eventually.

Flight was delayed “due to earlier delays of that plane”, so we were nearly three hours late.

There was a piece of plastic baked into my buttermilk biscuit! I have a pictures. The flight attendants in first class were really apologetic, and tried to rectify the situation. I I am very appreciative that they were able to give me some packets of pretzels and gummy bears. I understand they don't personally handle the food until warming it up so I know it wasn't their fault. I don't know whether it was a newer aircraft, or different food packaging, but I was happy that when the food was being warmed up - it didn't smell like plastic. Jokes on me with finding plastic in my food.

The seats were uncomfortable, as if the cushions haven't been switched out in many years. I felt like I was on an old bus. The food was delicious. thank you. Onboard entertainment, very limited. Unless you like violent movies. Why in the world would you have such severely violent movies on a plane? if you don't want to see such things, you don't have a choice. Have you considered that when choosing entertainment? Good god. Why would you have the Godfather? Or black women being brutally beaten with a club? Why in the hell would you put that kind of material on a plane? As for Kayak: Why when I ordered Qantas, was the plane on United?

The head rest is too big and cannot be placed differently/removed. Causes one head to tilt forward and increase back pain

It was terribly delayed with zero support from united airlines. I reached at 1 am in the night. They did not provide any option to change the flights.

It was great. All the crew were professional and nice.

Flight was delayed 14 hours due to DC air show and weather. Missed connection to MUC.

Awful. No counter attendants. No dinner offered due to delays.

Flight was great. On time. Pleasant crew and responsible passengers. My only disappointment was that there was no coffee or tea offered. It was a short flight but a coffee would have been appreciated for what the price of tickets are now.

The price was the only good thing about this flight. It was scary during takeoff when the plane tilted side to side. It made me feel very nervous as I have never had a take-off that unsmooth. There was no on-flight movie or music options and the only complimentary option was water. Other airlines offer trail mix or a caramel cookie and pop options as complimentary. This flight was a 2.5 hour flight. I understand for shorter flights not having options, but a flight 2 hours or longer should offer more complimentary options and in flight entertainment. Also the seats did not recline and for a longer flight reclining seats are a must for comfort.

A very pleasant flight but it would be greatly improved with wifi to help entertain kids

This is a no frills, get it done, efficient airline. The seat is a lawn chair. You better bring your own entertainment. If you want something other than water you need to pay for it. But they will get you to your destination quickly, on time, and then they will turn the flight around and go right back where they came from. Reliably. Couple times a week tops. If it fits into your schedule, you can’t get there cheaper or faster.

A three hour delay to board and then another hour on the tarmac because they couldn't get a tractor? Ugh.

Allegiant canceled the flight. The flight the next day was full. Allegiant did not provide any compensation besides a refund. Last time on Allegiant.

Seats were very uncomfortable and being charged for snacks and water.........

It was canceled. The flight wasn’t rescheduled, everyone had to figure out their own new arrangements. They said we would get refunded our original fare and receive an additional $150. We received links for $100 only and they expired before we could activate them.

I didn't even take this flight. My plans changed and I couldn't get ahold of customer service and the website kept breaking down during the attempt to change the flight. I wound up taking another airline entirely and eating the cost.

We had a 4-hour delay due to a maintenance issue. We boarded, deplaned, then boarded again.

No frills, value airline. This trip was exactly what I expected. The flight was on time departing and arrived ahead of schedule. The crew was very efficient at getting people on and off the plane. I think the carry-on bag charges discouraged most people from bringing one, which led to quicker de-planing. I was careful to only bring a carefully packed personal item that was under the size limit. If you keep in mind that everything costs extra with this airline (including snacks, drinks, and printing boarding passes), and go into this with the right expectations, then all will be well. For the price difference, I would fly this airline again. My flight was only 1 hr. 20 minutes though. Much longer than that and comfort might drive me to another airline. The seats are very basic and don't recline at all.

Passenger was too loud for the entire flight crew not once ask them to tame it …. Many passengers are uncomfortable including having headaches

Very turbulent flight, no drinks, very little service, unorganized boarding, gate changed multiple times

The Mario was so helpful and provided amazing customer service however l have being waiting for a callback for almost a week now and have not heard anything further after l informed them l wanted to change my date of traveling because of my hospital appointment even send them proof and l was unable to use manag your booking on their website is a bit frustrating and l would appreciate an update on My request as soon as possible. And have called them times without numbers no response

There is no room, no gluten free options, or any free internet/entertainment. You have to bring your own tablet or smartphone because there are no screens.

April was the flight attendant in first class and was the most pleasant, cordial and efficient person I have seen on a flight in years. Good example of the type of people AA should hire to increase customer satisfacdtion.

Excellent accommodating crew at gate and on board. Baggage claim and gate checking were flawless.

Delayed 6 times. Eventually rebooked and missed a whole day of my vacation. Hot mess

Unfriendly gate staff and significant delay once we were on the plane.

I am tired of being nickel and dimed for seat location, checked luggage and carry on bags. That is why i rarely fly anymore.

Did not get to Ontario yet. Sitting on tarmac for 2 plus hours.

Everything you need to know for your flight from Indianapolis to South Carolina

Information on your arrival and departure airports