EYW - TYS

$57 Find Cheap Flights from Key West to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 10/27. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to Knoxville, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Key West to Knoxville (EYW-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Key West to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to Knoxville

Wed, Dec 31 - Sun, Jan 4
Allegiant Air Logo
8:45 pm - 11:00 pmEYW-TYS
2h 15mnonstop
Allegiant Air Logo
1:01 pm - 3:12 pmTYS-EYW
2h 11mnonstop
$199Allegiant Air
Find Deal
Sat, Oct 11 - Fri, Oct 17
Allegiant Air Logo
9:52 am - 9:08 pmEYW-TYS
11h 16m1 stop
Allegiant Air Logo
12:07 pm - 2:18 pmTYS-EYW
2h 11mnonstop
$255Allegiant Air
Find Deal
Wed, Dec 31 - Sun, Jan 4
Allegiant Air Logo
8:45 pm - 11:00 pmEYW-TYS
2h 15mnonstop
Allegiant Air Logo
5:13 pm - 9:47 pmTYS-EYW
4h 34m1 stop
$268Allegiant Air
Find Deal
Sat, Oct 11 - Sat, Oct 18
Allegiant Air Logo
9:52 am - 9:08 pmEYW-TYS
11h 16m1 stop
Allegiant Air Logo
9:58 pm - 4:04 pmTYS-EYW
18h 06m1 stop
$296Allegiant Air
Find Deal
Sat, Oct 11 - Thu, Oct 16
Multiple Airlines Logo
9:52 am - 9:08 pmEYW-TYS
11h 16m1 stop
Multiple Airlines Logo
9:25 pm - 9:17 amTYS-EYW
11h 52m1 stop
$306Multiple Airlines
Find Deal
Sun, Oct 12 - Fri, Oct 17
Multiple Airlines Logo
8:55 am - 11:16 pmEYW-TYS
38h 21m3 stops
Multiple Airlines Logo
12:07 pm - 2:18 pmTYS-EYW
2h 11mnonstop
$323Multiple Airlines
Find Deal
Sat, Mar 7 - Tue, Mar 10
Delta Logo
6:00 pm - 10:07 amEYW-TYS
16h 07m1 stop
Delta Logo
6:10 am - 12:41 pmTYS-EYW
6h 31m1 stop
$428Delta
Find Deal
Sat, Mar 7 - Tue, Mar 10
American Airlines Logo
3:57 pm - 9:39 pmEYW-TYS
5h 42m1 stop
American Airlines Logo
12:40 pm - 6:30 pmTYS-EYW
5h 50m1 stop
$433American Airlines
Find Deal
Sat, Mar 7 - Tue, Mar 10
American Airlines Logo
3:57 pm - 9:39 pmEYW-TYS
5h 42m1 stop
American Airlines Logo
2:25 pm - 11:59 pmTYS-EYW
9h 34m2 stops
$455American Airlines
Find Deal
Wed, Dec 31 - Sun, Jan 4
United Airlines Logo
5:00 pm - 5:00 pmEYW-TYS
24h 00m2 stops
United Airlines Logo
5:45 am - 2:13 pmTYS-EYW
8h 28m2 stops
$612United Airlines
Find Deal

Everything you should know

Top airlines
Allegiant Air
Cheapest • from $199 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
4 days a week
There are direct flights from Key West to Knoxville 4 days a week: Mon, Wed, Fri, Sun.
Direct flights
Direct flights
Direct flights
Direct flights
Cheapest round-trip
$199
Allegiant Air
Wed 12/31Sun 1/4
EYW - TYS • Non-stop
Cheapest one-way
$57
Typical prices: $263-345
Allegiant Air
Mon 10/27
EYW - TYS • Non-stop
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Booking Insights

KAYAK's insights & trends for Key West to Knoxville flights

Get data-powered insights and trends into flights from Key West to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Key West to Knoxville?

The average price of all round-trip flights from Key West to Knoxville clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Knoxville on a Friday, as we generally find the cheapest rates on that day for this route. On the other hand, Sunday is the most expensive day to fly from Key West to Knoxville. For your return ticket, we recommend flying on a Monday and avoiding Tuesdays for the best deals.

Can I save money by flying with a layover from Key West to Knoxville?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $498, prices are generally cheapest when you fly direct.

Good to know

Low seasonOctober
Cheapest flight$57
Best time to beat the crowds with an average 37% drop in price.
Most popular time to fly with an average 55% increase in price.
Flight from Key West to Knoxville

When to book flights from Key West to Knoxville

Are your dates flexible? Find out the best times to travel from Key West to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Key West to Knoxville

  • How many flights are there between Key West and Knoxville per day?

    There is a maximum of 1 nonstop flight a day that takes off from Key West and lands in Knoxville, with an average flight time of 2h 15m. The most common departure time is 8:00 am and most flights take off in the morning. Each week, there are 2 flights.

  • What is the cheapest flight from Key West to Knoxville?

    In the last 3 days, the lowest price for a flight from Key West to Knoxville was $57 for a one-way ticket and $199 for a round-trip.

  • Do I need a passport to fly between Key West and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Key West to Knoxville?

    When flying out of Key West you will be using Key West. You will be landing at Knoxville, also known as Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Key West to Knoxville?

    The Airbus A319 is the aircraft model that flies most regularly on the Key West to Knoxville flight route.

  • On which days can I fly direct from Key West to Knoxville?

    You can catch a nonstop flight from Key West to Knoxville on on Monday, and Friday.

  • Which is the best airline for flights from Key West to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Key West to Knoxville are Delta and American Airlines. With an average price for the route of $393 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $398 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Key West to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Key West to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Key West to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Key West is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Key West to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Key West with another airline. Booking your flights between Key West and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Key West to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Key West up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Prefer to fly direct from Key West to Knoxville?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Key West to Knoxville McGhee Tyson.
Find which airlines fly direct from Key West Airport to Knoxville McGhee Tyson Airport, which days they fly and book direct flights.

Direct departures

Key West to Knoxville McGhee Tyson

Monday

Allegiant Air

Allegiant Air

Wednesday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

Sunday

Allegiant Air

Allegiant Air

See more direct flights

Direct returns

Knoxville McGhee Tyson to Key West

Monday

Allegiant Air

Allegiant Air

Wednesday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

Sunday

Allegiant Air

Allegiant Air

See more direct flights

Reviews of the top airlines flying from Key West to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Key West to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Key West to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7954 reviews
7.9Comfort
8.2Boarding
7.9Entertainment
7.3Food
8.5Crew
Airline reviews

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

8.0 ExcellentOlaf, Sep 2025FLL - ATL
Read more Delta reviews

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Flight was an hour late, who knows why. It was OK, nothing outstanding.

Excellent check-in. Crew was good. Excellent communication from flight deck.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

The Dekta Rep that checked us in was great. She's very personable, pleasant, and can tell she enjoys her job.

Kind staff. Snacks are small but that’s the new normal.

The young man who was our flight attendant in first class was lazy and did not do his job well at all. Never offered drinks upon boarding - actually I take that back... said "are you okay with water" as if I do not want to get you anything else, only passed the snacks around once, got my drink order wrong and then never offered a second round of drinks. He was the worst I have ever seen on Delta and we fly a lot.

We will be writing a long, detailed letter to corporate about our awful experience with American airlines.

Internet was a bit expensive and did not work ask that week otherwise a good flight

Food was ok, but not as good as I have had before on AA.

Pretty good. The food was just mediocre, the boarding and crew were good.

Crew should be nicer and emphatic with customers. Same cookies as the past 20 years. Seat are ok and the plane was clean though it was delayed.

Plane was delayed for 6 hours, at first by weather, which is understandable, but was further delayed with NO given reason for 2 1/2 hours more. We had no clue when we were going to depart actually until they opened the ramp. VERY POOR to ZERO COMMUNICATION!!!

It was very difficult to stretch my knee out and I am very short. I also had a torn tendon in my knee which made it extra uncomfortable anyways. My husband is 6'2" and I can't imagine him flying in that plane.

Delayed because of weather in Nashville. I think God or some higher power generally has cursed me when it comes to flying out of Charlotte on American. I'm delayed pretty much everytime. We need Team Cobra Kai types to come in and "sweep the leg(s)" of the Charlotte ops people on principle. Don't let the sweet southern rocking chairs fool you, Charlotte is a sinkhole

It was one of my worst flight ever. First they were changing the gate for at least 4 times, changing from gate D7 to D12 to D44. Considering the size of the Miami Airport, we are talking about long distance and the train at the airport was not working. Then the flight was delayed around one hour. Then finally we boarded into the plane and when everybody was seated, there was an announcement that there is an issue with one of the tire of the plane, so we all had to get out of the plane with our belongings, to replace the tire. So we had around 2.5-hour delay

I was late from Jacksonville, FL but the limited interaction I had with the Philly crew was great.

Everything you need to know for your flight from Key West to Knoxville

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