EYW - TYS

$160 Find Cheap Flights from Key West to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 4/28. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$302
Multiple Airlines
Tue 3/31Sat 4/4
EYW - TYS • 1 stop
Cheapest one-way
$160
Typical prices: $293-$307
Multiple Airlines
Tue 4/28
EYW - TYS • 2 stops
Nonstop flights
2 days a week
Mon, Fri
You can fly direct with Allegiant Air. Average duration is 2h 15m
Direct flights
Direct flights
+1
+1
Direct flights
Direct flights
+1
Top airlines
Cheapest • from $471 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Top layover airports
Cheapest • Avg $455 (round-trip)
Shortest trip • 4h 06m (one-way)
Insights
Insights
Insights
Insights
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Key West to Knoxville (EYW-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Key West to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to Knoxville

Tue, Mar 31 - Sat, Apr 4
Multiple Airlines Logo
12:25 pm - 10:36 am
EYW
-
TYS
22h 11m
1 stop
Multiple Airlines Logo
1:45 pm - 2:52 pm
TYS
-
EYW
25h 07m
1 stop
$302Multiple Airlines
Tue, Mar 31 - Sat, Apr 4
Multiple Airlines Logo
1:01 pm - 10:36 am
EYW
-
TYS
21h 35m
2 stops
Multiple Airlines Logo
1:45 pm - 2:52 pm
TYS
-
EYW
25h 07m
1 stop
$321Multiple Airlines
Mon, Mar 30 - Fri, Apr 10
American Airlines Logo
7:42 pm - 11:59 pm
EYW
-
TYS
4h 17m
1 stop
American Airlines Logo
3:58 pm - 10:36 pm
TYS
-
EYW
6h 38m
1 stop
$471American Airlines
Mon, Mar 30 - Fri, Apr 10
Delta Logo
6:25 pm - 11:57 pm
EYW
-
TYS
5h 32m
1 stop
Delta Logo
5:40 am - 10:48 am
TYS
-
EYW
5h 08m
1 stop
$473Delta
Mon, Mar 30 - Fri, Apr 10
American Airlines Logo
7:42 pm - 11:59 pm
EYW
-
TYS
4h 17m
1 stop
American Airlines Logo
2:06 pm - 10:58 pm
TYS
-
EYW
8h 52m
2 stops
$568American Airlines
Mon, Mar 30 - Fri, Apr 10
American Airlines Logo
12:55 pm - 8:05 pm
EYW
-
TYS
7h 10m
1 stop
American Airlines Logo
3:58 pm - 10:58 pm
TYS
-
EYW
7h 00m
2 stops
$608American Airlines
Mon, Apr 20 - Mon, Apr 27
American Airlines Logo
4:20 pm - 11:55 pm
EYW
-
TYS
7h 35m
1 stop
American Airlines Logo
5:57 pm - 10:36 pm
TYS
-
EYW
4h 39m
1 stop
$669American Airlines
Mon, Apr 20 - Mon, Apr 27
American Airlines Logo
4:20 pm - 10:24 pm
EYW
-
TYS
6h 04m
1 stop
American Airlines Logo
3:58 pm - 10:58 pm
TYS
-
EYW
7h 00m
2 stops
$674American Airlines
Mon, Apr 20 - Mon, Apr 27
United Airlines Logo
6:22 pm - 10:08 am
EYW
-
TYS
15h 46m
2 stops
United Airlines Logo
7:20 pm - 5:39 pm
TYS
-
EYW
22h 19m
2 stops
$732United Airlines
Mon, Apr 20 - Mon, Apr 27
United Airlines Logo
6:22 pm - 10:08 am
EYW
-
TYS
15h 46m
2 stops
United Airlines Logo
7:00 am - 3:57 pm
TYS
-
EYW
32h 57m
2 stops
$742United Airlines
Booking Insights

KAYAK's insights & trends for Key West to Knoxville flights

Get data-powered insights and trends into flights from Key West to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Key West to Knoxville?

The average price of all round-trip flights from Key West to Knoxville clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Knoxville on a Monday, as we generally find the cheapest rates on that day for this route. On the other hand, Friday is the most expensive day to fly from Key West to Knoxville. For your return ticket, we recommend flying on a Wednesday and avoiding Fridays for the best deals.

Can I save money by flying with a layover from Key West to Knoxville?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $148, prices are generally cheapest when you fly direct.

Good to know

Low seasonMarch
Cheapest flight$160
Best time to beat the crowds with an average 62% drop in price.
Most popular time to fly with an average 67% increase in price.
Flight from Key West to Knoxville

When to book flights from Key West to Knoxville

Are your dates flexible? Find out the best times to travel from Key West to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Key West to Knoxville

  • What is the cheapest flight from Key West to Knoxville?

    In the last 3 days, the lowest price for a flight from Key West to Knoxville was $160 for a one-way ticket and $302 for a round-trip.

  • Do I need a passport to fly between Key West and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Key West to Knoxville?

    When flying out of Key West you will be using Key West. You will be landing at Knoxville, also known as Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Key West to Knoxville?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Key West to Knoxville flight route.

  • Which airline alliances offer flights from Key West to Knoxville?

    SkyTeam, and oneworld are the airline alliances operating flights between Key West and Knoxville, with SkyTeam being the most commonly used for this route.

  • On which days can I fly direct from Key West to Knoxville?

    You can catch a nonstop flight from Key West to Knoxville on on Monday, and Friday.

  • Which is the best airline for flights from Key West to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Key West to Knoxville are Delta and American Airlines. With an average price for the route of $498 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $485 and an overall rating of 7.1.

  • How does KAYAK find such low prices on flights from Key West to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Key West to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Key West to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Key West is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Key West to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Key West with another airline. Booking your flights between Key West and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Key West to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Key West up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Prefer to fly direct from Key West to Knoxville?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Key West to Knoxville McGhee Tyson.
Find which airlines fly direct from Key West Airport to Knoxville McGhee Tyson Airport, which days they fly and book direct flights.

Direct departures

Key West to Knoxville McGhee Tyson

Monday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

See more direct flights

Direct returns

Knoxville McGhee Tyson to Key West

Monday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

See more direct flights

Reviews of the top airlines flying from Key West to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Key West to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Key West to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8288 reviews
7.9Comfort
7.8Entertainment
7.2Food
8.1Boarding
8.5Crew
Airline reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

10.0 ExcellentDebra, Mar 2026
PBI - ATL
Read more Delta reviews

Perhaps when you’re sitting in 1st class and the crew closes the bathroom for the pilots, there could be a notification other than holding your hands up as a blockade when you get there and you’re told the restrooms are closed please turn around … especially at night when visibility is poor and you’re met by a flight attendants with their arms up

Loved flying First Class. Very comfortable. The seat was amazing. Enjoyed a movie and was able to relax so much better than in coach.

We landed and sat on the tarmac for 45 minutes because they only have one gate at the airport and there was another plane running late so we had to wait

Same experience as the flight from Norfolk to Atlanta where people are boarded in zones that don't make sense. People behind you on the plane will get on before you and they take the luggage space on your row.

An awesome flight crew. FC seat cushion just doesn’t cut it for a 3+ hour flight.

Delta continues to set the benchmark for traveler-friendly service with minimal disruption and clear communication within the mainland US (coast to coast). I am consistently pleased to be a Delta customer, and this experience once again met my expectations. There was a brief delay departing from MIA due to a technical issue that required the aircraft to return to the gate. However, the situation was handled professionally and transparently. Fortunately, my planned layover allowed ample buffer time, so the adjustment caused no stress. Overall, another smooth and reassuring experience.

Totally worth the miles to upgrade to Delta Comfort. Plenty of legroom.

This was my first time flying Delta ever and I had a great experience!

Smallest leg room I've ever had on a plane.

The flight was great as well as the airline staff

After changing the departure gate 5 times making us mo e from one side of the airport to the other and then back the flight was delayed nearly 2 hours. The male flight attendant had a bad attitude with the guest being condescending, disrespectful with people who were already on edge.

There was no beverage service and the only time I saw a crew member walk through the cabin is when we were preparing to land.

Flights were constantly delayed. CRW took 50 minutes to get bags

Where do I start!! I was delayed with my flight from Dallas to Tampa. On the way back from Tampa to Dallas the flight was delayed over 4 hours+. I was put on another flight that was also delayed but not as long. Traveling on American Airlines is becoming exhausing.

I didn't end up taking this flight. I got up at 4am for a flight that was supposed to board at 6am - at 5:55am you delayed the flight to 10am. The airport is under construction so I switched to a later flight as I wasn't going to sit in the airport for 4 hours. They said the delay was due to the crew needing rest from a flight coming in late the night before - if that was the case then I think you should have delayed the flight much sooner so that passengers wouldn't get up so early and get to the airport to sit and wait.

The flight attendants and the service is getting worse by the day.

Other than nearly three hour delay for maintenance issues, everything went smooth

why would I bother with this airline and pick seats when I am asked to move for a weight imbalance

Overall good. The pilots and flight attendants are excellent! The equipment was the issue on my First flight as they had to wait for a part to be installed. So the take off was at least 30 minutes later.

For my arriving destination, we were delayed multiple times to the point that we arrived 6 hours after we were originally scheduled. On my flight home, they overbooked and involuntarily removed passengers (including me) from the plane. It was not a good experience.

Everything you need to know for your flight from Key West to Knoxville

Information on your arrival and departure airports