EYW - TYS

$136 Find Cheap Flights from Key West to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to Knoxville, as well as popular online travel agencies
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Everything you should know

Cheapest round-trip
$153
Allegiant Air
Fri 5/8Mon 5/18
EYW - TYS • Non-stop
Cheapest one-way
$136
Typical prices: $227-$242
Allegiant Air
Thu 4/23
EYW - TYS • 1 stop
Top airlines
Allegiant Air
Cheapest • from $153 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
2 days a week
There are direct flights from Key West to Knoxville 2 days a week: Mon, Fri.
Direct flights
Direct flights
Direct flights
Direct flights
Start a new search
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We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Key West to Knoxville (EYW-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Key West to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to Knoxville

Fri, May 8 - Mon, May 18
Allegiant Air Logo
11:01 am - 1:16 pm
EYW
-
TYS
2h 15mnonstop
Allegiant Air Logo
8:00 am - 10:11 am
TYS
-
EYW
2h 11mnonstop
$153Allegiant Air
Mon, Jun 8 - Fri, Jun 12
Allegiant Air Logo
9:01 am - 11:16 am
EYW
-
TYS
2h 15mnonstop
Allegiant Air Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
$156Allegiant Air
Mon, Jun 8 - Fri, Jun 12
Multiple Airlines Logo
12:10 pm - 11:34 pm
EYW
-
TYS
11h 24m
1 stop
Multiple Airlines Logo
7:30 am - 9:41 am
TYS
-
EYW
2h 11mnonstop
$231Multiple Airlines
Fri, May 8 - Mon, May 18
Allegiant Air Logo
3:33 pm - 9:48 pm
EYW
-
TYS
6h 15m
1 stop
Allegiant Air Logo
8:00 am - 10:11 am
TYS
-
EYW
2h 11mnonstop
$247Allegiant Air
Fri, May 8 - Mon, May 18
Multiple Airlines Logo
12:10 pm - 11:06 am
EYW
-
TYS
22h 56m
2 stops
Multiple Airlines Logo
8:00 am - 10:11 am
TYS
-
EYW
2h 11mnonstop
$312Multiple Airlines
Mon, Jun 8 - Fri, Jun 12
Multiple Airlines Logo
12:10 pm - 11:34 pm
EYW
-
TYS
11h 24m
1 stop
Multiple Airlines Logo
7:00 pm - 1:58 pm
TYS
-
EYW
18h 58m
1 stop
$323Multiple Airlines
Fri, May 8 - Mon, May 18
Multiple Airlines Logo
11:01 am - 1:16 pm
EYW
-
TYS
2h 15mnonstop
Multiple Airlines Logo
1:15 pm - 11:06 am
TYS
-
EYW
45h 51m
3 stops
$335Multiple Airlines
Mon, Jun 8 - Fri, Jun 12
Multiple Airlines Logo
9:01 am - 11:16 am
EYW
-
TYS
2h 15mnonstop
Multiple Airlines Logo
7:22 pm - 10:24 am
TYS
-
EYW
39h 02m
3 stops
$341Multiple Airlines
Fri, Feb 13 - Tue, Feb 17
Delta Logo
5:56 pm - 11:52 pm
EYW
-
TYS
5h 56m
1 stop
Delta Logo
5:35 am - 10:59 am
TYS
-
EYW
5h 24m
1 stop
$401Delta
Fri, Feb 13 - Tue, Feb 17
American Airlines Logo
4:40 pm - 9:55 pm
EYW
-
TYS
5h 15m
1 stop
American Airlines Logo
8:50 am - 4:49 pm
TYS
-
EYW
7h 59m
2 stops
$406American Airlines
Booking Insights

KAYAK's insights & trends for Key West to Knoxville flights

Get data-powered insights and trends into flights from Key West to Knoxville to help you find the cheapest flights, the best time to fly and much more.

Can I save money by flying with a layover from Key West to Knoxville?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $320, prices are generally cheapest when you fly direct.

Good to know

Low seasonDecember
Cheapest flight$136
Best time to beat the crowds with an average 46% drop in price.
Most popular time to fly with an average 58% increase in price.
Flight from Key West to Knoxville

When to book flights from Key West to Knoxville

Are your dates flexible? Find out the best times to travel from Key West to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Key West to Knoxville

  • What is the cheapest flight from Key West to Knoxville?

    In the last 3 days, the lowest price for a flight from Key West to Knoxville was $136 for a one-way ticket and $153 for a round-trip.

  • Do I need a passport to fly between Key West and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Key West to Knoxville?

    When flying out of Key West you will be using Key West. You will be landing at Knoxville, also known as Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Key West to Knoxville?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Key West to Knoxville flight route.

  • Which airline alliances offer flights from Key West to Knoxville?

    SkyTeam, and oneworld are the airline alliances operating flights between Key West and Knoxville, with SkyTeam being the most commonly used for this route.

  • On which days can I fly direct from Key West to Knoxville?

    You can catch a nonstop flight from Key West to Knoxville on on Monday, and Friday.

  • Which is the best airline for flights from Key West to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Key West to Knoxville are Delta and American Airlines. With an average price for the route of $498 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $389 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Key West to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Key West to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Key West to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Key West is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Key West to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Key West with another airline. Booking your flights between Key West and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Key West to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Key West up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Prefer to fly direct from Key West to Knoxville?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Key West to Knoxville McGhee Tyson.
Find which airlines fly direct from Key West Airport to Knoxville McGhee Tyson Airport, which days they fly and book direct flights.

Direct departures

Key West to Knoxville McGhee Tyson

Monday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

See more direct flights

Direct returns

Knoxville McGhee Tyson to Key West

Monday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

See more direct flights

Reviews of the top airlines flying from Key West to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Key West to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Key West to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8130 reviews
8.1Boarding
7.2Food
8.5Crew
7.8Entertainment
7.9Comfort
Airline reviews

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

10.0 ExcellentSteven, Jan 2026
FLL - CVG
Read more Delta reviews

Excellent flight and got us around tough weather. Only issue was seat TV did not work and crew tried to reboot.

Connection through Atlanta was difficult. Mechanical issue on plane caused a two hour delay. New gate was a mile away.

No WiFi. Comfort plus should have alcohol provided, crew only offered water or tea. Who the heck wants tea?

I have diamond medallion status and usually we are in comfort plus . We were in main this time ( which was fine ) and my husband wanted wine . I have at least 10 vouchers for drinks that are good for this year and next! The attendant would not take the picture of the voucher as proof and never came back to check as She asked me to pull it up on delta Wi-Fi. Instead my husband just used his Amex to buy the wine . Disappointing!!!

Food is basically Sun Chips, cookies or Cheezits. I had an exit row seat so I had plenty of room. The crew was very nice and efficient. Pilot kept us informed. Pretty good flight.

The only thing nice I can say is the flight crew was really nice and apologetic about the situation. They shared as much information as they had and advised us on what we could do about missing connecting flights. The boarding process was so slow. The gate agent was working by herself and should have had someone working with her. It took almost an hour to board because she was trying to board a full flight of people and provide customer service to everyone who was flying standby and/or had questions. It was really chaotic. This didn't help the fact that we were delayed and folks were missing connections the longer it took.

The plant way delayed departing by 3 hours. It was an old airplane with broken seats and armrests. The bathroom made a hollering sound. A really crappy flight experience and travel day all around.

The food is terrible. The staff is wonderful. Comfort is good.

I fly Delta all the time, have Platinum Medallion status. But this route seems to have major problems with delays and seems to never leave on time! Have only taken it twice in the last two weeks, and each time it had delays of more than 1 hour... very disappointed!!!!

We had a lot of really rough weather but that was not Delta's fault. Pilot was amazing.

Flight was smooth, quick and felt safe. The 2 delays not happening would have been better but I guess that happens in the airline industry

On time on a day with lots of weather cancellations on other flights. Thank you for getting me home during a winter storm!

Don't change gate multiple times make people run across the airport. Announce delays in a timely manner. Have maintenance crew ready. Don't delay and keep passengers on the plane for 3 hrs. on tarmac.

The attendants were kind and helpful. A sugar-free drink would have been very welcome.

Little warm on the plane and delayed for an hour

UGH I HAD TO MISS MY FIRST FLIGHT TO TAMPA CAUSE OF THE 10 MINUTE DELAY OF THE ORLANDO TO MIAMI ONE SO THEY HAD ME GET ANOTHER TICKET. I AM NOT HAPPY AT ALL BECAUSE IT MADE ME MISS MY CONNECTING FLIGHT FROM TAMPA TO LONDON AND FORCED ME TO MISS A DAY AT MY ROOM IN THE UK.

Wish they didnt delay off-boarding for 10 minutes so i could connect to my flight from miami to tampa

It was fine. My connection in Charlotte to go to WPB was too late and I had to spend the night in the Charlotte Airport in the mini suites.

Boarding was organized and timely. Food was mediocre, especially for first class travel.

We were 4+ hours delayed. AA is absolutely obnoxious. They just kept pushing back the time to the point where we did not get into Vegas until after midnight when we were supposed to arrive like 845pm.

Everything you need to know for your flight from Key West to Knoxville

Information on your arrival and departure airports