EYW - TYS

$65 Find Cheap Flights from Key West to Knoxville - Compare and Save

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$319
Typical prices: $145-$1,060
American Airlines
Thu 12/10Mon 12/14
EYW - TYS • 1 stop
Cheapest one-way
$65
Allegiant Air
Fri 11/6
EYW - TYS • Non-stop
Nonstop flights
2 days a week
Mon, Fri
You can fly direct with Allegiant Air. Average duration is 2h 15m
Direct flights
Direct flights
+1
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Direct flights
Direct flights
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Top airlines
Cheapest • from $319 (round-trip)
Best reviews • 7.3 score
Airline reviews
Airline reviews
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Airline reviews
Airline reviews
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Top layover airports
Cheapest • Avg $288 (round-trip)
Shortest trip • 4h 06m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 100% price drop
Most popular
Good to know
Good to know
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Good to know
Good to know
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Key West to Knoxville (EYW-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Key West to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to Knoxville

Thu, Dec 10 - Mon, Dec 14
American Airlines Logo
8:00 am - 2:29 pm
EYW
-
TYS
6h 29m
1 stop
American Airlines Logo
2:55 pm - 9:45 pm
TYS
-
EYW
6h 50m
1 stop
$319American Airlines
Fri, Sep 4 - Mon, Sep 7
American Airlines Logo
1:35 pm - 7:10 pm
EYW
-
TYS
5h 35m
1 stop
American Airlines Logo
6:06 am - 1:05 pm
TYS
-
EYW
6h 59m
1 stop
$339American Airlines
Fri, Sep 4 - Mon, Sep 7
Multiple Airlines Logo
12:07 pm - 10:56 pm
EYW
-
TYS
10h 49m
1 stop
Multiple Airlines Logo
7:06 pm - 12:34 pm
TYS
-
EYW
17h 28m
2 stops
$360Multiple Airlines
Fri, Sep 4 - Mon, Sep 7
American Airlines Logo
1:35 pm - 8:59 pm
EYW
-
TYS
7h 24m
2 stops
American Airlines Logo
5:15 am - 1:05 pm
TYS
-
EYW
7h 50m
2 stops
$554American Airlines
Thu, Dec 10 - Mon, Dec 14
American Airlines Logo
4:10 pm - 11:57 pm
EYW
-
TYS
7h 47m
2 stops
American Airlines Logo
2:55 pm - 9:45 pm
TYS
-
EYW
6h 50m
1 stop
$573American Airlines
Thu, Dec 10 - Mon, Dec 14
United Airlines Logo
2:30 pm - 10:00 am
EYW
-
TYS
19h 30m
2 stops
United Airlines Logo
7:35 pm - 1:02 pm
TYS
-
EYW
17h 27m
2 stops
$776United Airlines
Fri, Aug 14 - Mon, Aug 17
United Airlines Logo
2:15 pm - 4:58 pm
EYW
-
TYS
26h 43m
2 stops
United Airlines Logo
7:20 pm - 1:29 pm
TYS
-
EYW
18h 09m
2 stops
$1,266United Airlines
Booking Insights

KAYAK's insights & trends for Key West to Knoxville flights

Get data-powered insights and trends into flights from Key West to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What’s the cheapest day of the week to fly from Key West to Knoxville?

The average price of all round-trip flights from Key West to Knoxville clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Knoxville on a Friday, as we generally find the cheapest rates on that day for this route. On the other hand, Monday is the most expensive day to fly from Key West to Knoxville. For your return ticket, we recommend flying on a Monday and avoiding Sundays for the best deals.

What is the cheapest month to fly from Key West to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Key West to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Key West to Knoxville is February, where tickets cost $0 (return) on average. On the other hand, the most expensive months are September and August, where the average cost of round-trip tickets is $603 and $572 respectively.

Can I save money by flying with a layover from Key West to Knoxville?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $228, prices are generally cheapest when you fly direct.

Good to know

Low season

March

Cheapest flight

$65
Best time to beat the crowds with an average 58% drop in price.
Most popular time to fly with an average 86% increase in price.
Flight from Key West to Knoxville

When to book flights from Key West to Knoxville

Are your dates flexible? Find out the best times to travel from Key West to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Key West to Knoxville

  • How many flights are there between Key West and Knoxville per day?

    There is a maximum of 1 nonstop flight a day that takes off from Key West and lands in Knoxville, with an average flight time of 2h 15m. The most common departure time is 10:00 am and most flights take off in the morning. Each week, there are 2 flights.

  • What is the cheapest flight from Key West to Knoxville?

    In the last 5 days, the lowest price for a flight from Key West to Knoxville was $65 for a one-way ticket and $319 for a round-trip.

  • Do I need a passport to fly between Key West and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Key West to Knoxville?

    When flying out of Key West you will be using Key West. You will be landing at Knoxville, also known as Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Key West to Knoxville?

    The Airbus A320-100/200 is the aircraft model that flies most regularly on the Key West to Knoxville flight route.

  • On which days can I fly direct from Key West to Knoxville?

    You can catch a nonstop flight from Key West to Knoxville on on Monday, and Friday.

  • How does KAYAK find such low prices on flights from Key West to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Key West to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Key West to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Key West is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Key West to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Key West with another airline. Booking your flights between Key West and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Key West to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Key West up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Key West to Knoxville

  • Looking for a cheap flight? 25% of our users found flights on this route for $107 or less one-way.

Prefer to fly direct from Key West to Knoxville?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Key West to Knoxville McGhee Tyson.
Find which airlines fly direct from Key West Airport to Knoxville McGhee Tyson Airport, which days they fly and book direct flights.

Direct departures

Key West to Knoxville McGhee Tyson

Monday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

See more direct flights

Direct returns

Knoxville McGhee Tyson to Key West

Monday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

See more direct flights

Reviews of the top airline flying from Key West to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Key West to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Key West to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.3
Allegiant AirOverall score based on 678 reviews
7.6Boarding
8.1Crew
6.9Comfort
5.5Entertainment
5.8Food
Airline reviews

This is a no frills, get it done, efficient airline. The seat is a lawn chair. You better bring your own entertainment. If you want something other than water you need to pay for it. But they will get you to your destination quickly, on time, and then they will turn the flight around and go right back where they came from. Reliably. Couple times a week tops. If it fits into your schedule, you can’t get there cheaper or faster.

10.0 ExcellentChristina, Jun 2026
PGD - PIT
Read more Allegiant Air reviews

This is a no frills, get it done, efficient airline. The seat is a lawn chair. You better bring your own entertainment. If you want something other than water you need to pay for it. But they will get you to your destination quickly, on time, and then they will turn the flight around and go right back where they came from. Reliably. Couple times a week tops. If it fits into your schedule, you can’t get there cheaper or faster.

Allegiant actually impressed me, original inbound flight from PBG was so late they gave us a bird inbound from Des Moines and only left 1h late and gained 40 minutes back in the air. Comfortable flight with no frills but no complaints.

Flight was delayed. Crew was good but hot coffee was not available.

It was cold on the flight. The crew was very pleasant. I didn't order any food. We were delayed due to Captain waiting on maintenance log. He kept us informed though. The flight itself was smooth. I would definitely fly with Allegiant again!

Superb. Staff great. Great flight. As with other airlines, seating too tight and restrictive.

WE were delayed about an hour and never any communications from the employees working the gate. We also were moved to a total of three gates.

Easiest flights I’ve ever taken. Plane was comfortable without overly crowded seating.

Flight was good, boarding was a breeze, flight attendants were friendly and professional. There was a medical issue with another passenger and the crew handled it in a calm and professional way.

Great seat space. However food and drink prices outrageous. Jabbing to pay for a carry on bag or stuck paying at the gate too much.

desk agent in sioux falls is rough .needs customer courtesy training

Everything you need to know for your flight from Key West to Knoxville

Information on your arrival and departure airports