EYW - TYS

$144 Find Cheap Flights from Key West to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Key West to Knoxville departing on 1/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Key West to Knoxville, as well as popular online travel agencies
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Flight Deals

Cheap Flights from Key West to Knoxville (EYW-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Key West to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Key West to Knoxville

Mon, Apr 6 - Fri, Apr 10
Allegiant Air Logo
11:01 am - 1:16 pmEYW-TYS
2h 15mnonstop
Allegiant Air Logo
8:00 am - 10:11 amTYS-EYW
2h 11mnonstop
$161Allegiant Air
Find Deal
Fri, Apr 3 - Mon, Apr 13
Allegiant Air Logo
11:01 am - 1:16 pmEYW-TYS
2h 15mnonstop
Allegiant Air Logo
8:00 am - 10:11 amTYS-EYW
2h 11mnonstop
$190Allegiant Air
Find Deal
Fri, Apr 3 - Fri, Apr 10
Allegiant Air Logo
11:01 am - 1:16 pmEYW-TYS
2h 15mnonstop
Allegiant Air Logo
8:00 am - 10:11 amTYS-EYW
2h 11mnonstop
$193Allegiant Air
Find Deal
Fri, Nov 14 - Tue, Nov 18
Multiple Airlines Logo
9:01 am - 11:16 amEYW-TYS
2h 15mnonstop
Multiple Airlines Logo
11:24 am - 10:07 amTYS-EYW
22h 43m2 stops
$218Multiple Airlines
Find Deal
Thu, Apr 9 - Fri, Apr 10
Allegiant Air Logo
3:08 pm - 10:33 pmEYW-TYS
7h 25m1 stop
Allegiant Air Logo
8:00 am - 10:11 amTYS-EYW
2h 11mnonstop
$221Allegiant Air
Find Deal
Tue, Apr 7 - Tue, Apr 14
Delta Logo
6:00 pm - 11:44 pmEYW-TYS
5h 44m1 stop
Delta Logo
5:30 am - 10:58 amTYS-EYW
5h 28m1 stop
$249Delta
Find Deal
Mon, Apr 6 - Mon, Apr 13
Multiple Airlines Logo
1:06 pm - 6:21 pmEYW-TYS
5h 15m1 stop
Multiple Airlines Logo
8:00 am - 10:11 amTYS-EYW
2h 11mnonstop
$263Multiple Airlines
Find Deal
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
1:36 pm - 6:36 pmEYW-TYS
5h 00m1 stop
American Airlines Logo
8:50 am - 3:56 pmTYS-EYW
7h 06m1 stop
$301American Airlines
Find Deal
Fri, Feb 20 - Tue, Feb 24
American Airlines Logo
1:36 pm - 6:36 pmEYW-TYS
5h 00m1 stop
American Airlines Logo
12:15 pm - 7:24 pmTYS-EYW
7h 09m2 stops
$306American Airlines
Find Deal
Tue, Apr 7 - Mon, Apr 13
Delta Logo
6:00 pm - 11:44 pmEYW-TYS
5h 44m1 stop
Delta Logo
5:30 am - 10:58 amTYS-EYW
5h 28m1 stop
$321Delta
Find Deal

Everything you should know

Top airlines
Allegiant Air
Cheapest • from $161 (round-trip)
Delta
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
When to travel
October
Cheapest • 47% price drop
August
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Nonstop flights
4 days a week
There are direct flights from Key West to Knoxville 4 days a week: Mon, Wed, Fri, Sun.
Direct flights
Direct flights
Direct flights
Direct flights
Cheapest round-trip
$161
Typical prices: $261-$286
Allegiant Air
Mon 4/6Fri 4/10
EYW - TYS • Non-stop
Cheapest non-stop
$161
Allegiant Air
Mon 4/6Mon 4/13
EYW - TYS • Non-stop
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KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Booking Insights

KAYAK's insights & trends for Key West to Knoxville flights

Get data-powered insights and trends into flights from Key West to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Key West to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Key West to Knoxville departing in April.

What’s the cheapest day of the week to fly from Key West to Knoxville?

The average price of all round-trip flights from Key West to Knoxville clicked on KAYAK for each day over the last 12 months.

If your flying dates are flexible, you should consider flying to Knoxville on a Friday, as we generally find the cheapest rates on that day for this route. On the other hand, Sunday is the most expensive day to fly from Key West to Knoxville. For your return ticket, we recommend flying on a Monday and avoiding Tuesdays for the best deals.

What is the cheapest month to fly from Key West to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Key West to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Key West to Knoxville is October, where tickets cost $203 (return) on average. On the other hand, the most expensive months are September and August, where the average cost of round-trip tickets is $603 and $572 respectively.

Can I save money by flying with a layover from Key West to Knoxville?

The average round-trip price for all non-stop flights, flights with one layover, and flights with two layovers for the route found by users searching on KAYAK in the last 2 weeks.

No, with an average price for the route of $197, prices are generally cheapest when you fly direct.

Good to know

Low seasonSeptember
Cheapest flight$144
Best time to beat the crowds but there is an average 57% increase in price.
Most popular time to fly with an average 49% increase in price.
Flight from Key West to Knoxville

When to book flights from Key West to Knoxville

Are your dates flexible? Find out the best times to travel from Key West to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from Key West to Knoxville

  • What is the cheapest flight from Key West to Knoxville?

    In the last 3 days, the lowest price for a flight from Key West to Knoxville was $144 for a one-way ticket and $161 for a round-trip.

  • Do I need a passport to fly between Key West and Knoxville?

    Even though you are not required to have a passport, keep in mind that an official ID is needed to board the airplane.

  • Which airports will I be using when flying from Key West to Knoxville?

    When flying out of Key West you will be using Key West. You will be landing at Knoxville, also known as Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from Key West to Knoxville?

    The Airbus A319 is the aircraft model that flies most regularly on the Key West to Knoxville flight route.

  • Which airline alliances offer flights from Key West to Knoxville?

    SkyTeam, and oneworld are the airline alliances operating flights between Key West and Knoxville, with SkyTeam being the most commonly used for this route.

  • On which days can I fly direct from Key West to Knoxville?

    You can catch a nonstop flight from Key West to Knoxville on on Monday, Wednesday, Friday, and Sunday.

  • Which is the best airline for flights from Key West to Knoxville, Delta or American Airlines?

    The two airlines most popular with KAYAK users for flights from Key West to Knoxville are Delta and American Airlines. With an average price for the route of $408 and an overall rating of 7.9, Delta is the most popular choice. American Airlines is also a great choice for the route, with an average price of $398 and an overall rating of 7.2.

  • How does KAYAK find such low prices on flights from Key West to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from Key West to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from Key West to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from Key West is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from Key West to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to Key West with another airline. Booking your flights between Key West and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from Key West to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from Key West up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

KAYAK’s top tips for finding a cheap flight from Key West to Knoxville

  • Looking for a cheap flight? 25% of our users found flights on this route for $96 or less one-way.

Prefer to fly direct from Key West to Knoxville?

 
Direct data is based off flight results for the next 60 days. Find direct flights from all airlines flying direct from Key West to Knoxville McGhee Tyson.
Find which airlines fly direct from Key West Airport to Knoxville McGhee Tyson Airport, which days they fly and book direct flights.

Direct departures

Key West to Knoxville McGhee Tyson

Monday

Allegiant Air

Allegiant Air

Wednesday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

Sunday

Allegiant Air

Allegiant Air

See more direct flights

Direct returns

Knoxville McGhee Tyson to Key West

Monday

Allegiant Air

Allegiant Air

Wednesday

Allegiant Air

Allegiant Air

Friday

Allegiant Air

Allegiant Air

Sunday

Allegiant Air

Allegiant Air

See more direct flights

Reviews of the top airlines flying from Key West to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Key West to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Key West to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 7992 reviews
8.2Boarding
7.9Entertainment
8.5Crew
7.9Comfort
7.3Food
Airline reviews

Non stop on long haul is the way to go. Great experience

10.0 ExcellentEric, Oct 2025MCO - ATL
Read more Delta reviews

Non stop on long haul is the way to go. Great experience

The boarding process needs to be refined. Sometimes the gate crew call out the boarding zone, and then flip to the monitor to show which zones are boarding. So unless everyone is gathered around to see the monitor there is usually confusion as wi which zones are boarding.

Really low quality food especially for an international flight. The crew also was surprisingly unpleasant except couple of ladies. I know we were not in first class but that’s no reason to treat customers as less.

For a 69 year old with health problems I had the worse experience, no wheelchair when I entered a lady told me to sit and wait while a gentleman told me I had to walk to the Delta station, which I did. I had a carry on and a bag, and I was traveling with my service dog, which was on his carrier and the lady charged me for my carry on luggage, beside all the waiting cause of the delay, I had to walk to get my luggage cause no wheelchair showed up, I am so disappointed. I will get in touch with the company. I got home at 3:00 am, not good for my health situation.

Flight was an hour late, who knows why. It was OK, nothing outstanding.

Excellent check-in. Crew was good. Excellent communication from flight deck.

Amazing flight! I have never noticed the uniforms of the attendants before in twenty years of flying except today when one female had the most amazing dress on. It was beautifully designed and showed she was in charge. I never dreamed I would google who designed Delta uniforms . The ultimate compliment is when another woman admires your outfit. . I hope your designer puts it on the market

This had nothing to do with Delta… The flights were on time and flawless. The service was excellent. We purchased seats in (aisle/middle) comfort plus since this was a cross country flight. Unfortunately, the woman seated at the window was 300+ pounds and, as might be expected, covered up about a third of the middle seat also. there was absolutely nothing that Delta could have done about that… I just don’t know what the answer should be. If you purchase a seat, you should should be able to use the entire seat and not just the portion that someone else is not sitting/oozing in. Disappointing…there should be something that could be done….I'm just not sure what solution could be.

The worst part was I was NOT allowed in the lounge even though I was holding a first class ticket and have a premium American Express card. I have flown Business or First Class with many airlines. Delta is the ONLY one who does not extend this courtesy to anyone except people who hold the very expensive American Express card. As a result, I won’t fly Delta if I have any other choice.

The Dekta Rep that checked us in was great. She's very personable, pleasant, and can tell she enjoys her job.

We had 3 flights. 1 & 2 were on the same plane but we had to de-board just to re-board 30 mins later. That may have been due to a crew change though. Our 3rd flight had a couple “maintenance” issues that held us up. They were quickly resolved but it took forever for someone to bring the paperwork needed so we could leave. Apparently there was a computer glitch so a driver had to bring a physical copy. It delayed us about 1 1/2 hrs. The flights themselves were smooth & no problems. For boarding, I don’t know why they don’t start with the back of the plane & move forward. It would eliminate the back up from people trying to find their seats & put their bags in the overhead bins. Unless you’re on an overseas flight, there is no food, you get a beverage & either a small bag of pretzels or a biscuit cookie. Take your own food or snacks of you want something more.

Lost bag and 2 days no word leaving for cruise no clothes or stuff

We will be writing a long, detailed letter to corporate about our awful experience with American airlines.

Internet was a bit expensive and did not work ask that week otherwise a good flight

Food was ok, but not as good as I have had before on AA.

Pretty good. The food was just mediocre, the boarding and crew were good.

Crew should be nicer and emphatic with customers. Same cookies as the past 20 years. Seat are ok and the plane was clean though it was delayed.

Plane was delayed for 6 hours, at first by weather, which is understandable, but was further delayed with NO given reason for 2 1/2 hours more. We had no clue when we were going to depart actually until they opened the ramp. VERY POOR to ZERO COMMUNICATION!!!

It was very difficult to stretch my knee out and I am very short. I also had a torn tendon in my knee which made it extra uncomfortable anyways. My husband is 6'2" and I can't imagine him flying in that plane.

Delayed because of weather in Nashville. I think God or some higher power generally has cursed me when it comes to flying out of Charlotte on American. I'm delayed pretty much everytime. We need Team Cobra Kai types to come in and "sweep the leg(s)" of the Charlotte ops people on principle. Don't let the sweet southern rocking chairs fool you, Charlotte is a sinkhole

Everything you need to know for your flight from Key West to Knoxville

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