$45 Find Cheap Flights from Key West to Knoxville - Compare and Save

If your flying dates are flexible, you should consider flying to Knoxville on a Friday, as we generally find the cheapest rates on that day for this route. On the other hand, Monday is the most expensive day to fly from Key West to Knoxville. For your return ticket, we recommend flying on a Wednesday and avoiding Sundays for the best deals.

The cheapest month for flights from Key West to Knoxville is February, where tickets cost $0 (return) on average. On the other hand, the most expensive months are September and August, where the average cost of round-trip tickets is $603 and $572 respectively.

In the past 5 days, the cheapest round-trip tickets from Key West to Knoxville were found on Allegiant Air ($73) and Delta ($309).

There is just one airline that flies from Key West to Knoxville direct and that is Allegiant Air. The best round-trip deal found from Allegiant Air for the route is $92.

Atlanta (ATL) is the top choice – 40% of KAYAK users who clicked on 1-stop flights from Key West to Knoxville picked an itinerary connecting there.

Flights via Tampa (PIE) offer the most affordable fares, with an average round-trip price of $288.

Consider flying via Miami (MIA) for the shortest journey. The average one-way travel time for flights connecting there is 4h 06m.

If you prefer a quick connection, Charlotte (CLT) often has the shortest layovers from Key West to Knoxville, with an average of 1h 15m.

There is only one cabin class option available for the route, which is Economy. Perform a search on KAYAK to find the latest prices and availability for all cabin fares, which differ across airlines.

There is a maximum of 1 nonstop flight a day that takes off from Key West and lands in Knoxville, with an average flight time of 2h 15m. The most common departure time is 10:00 am and most flights take off in the morning. Each week, there are 2 flights.