TYS - SNA

$167 Find Cheap Flights from Knoxville to John Wayne (Santa Ana) - Compare and Save

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Everything you should know

Cheapest round-trip
$320
Typical prices: $422-$696
American Airlines
Fri 11/9Wed 11/14
TYS - SNA • 1 stop
Cheapest one-way
$182
Typical prices: $218-$368
American Airlines
Sat 10/20
TYS - SNA • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Knoxville and Santa Ana. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
December
Cheapest • 35% price drop
October
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Las Vegas Harry Reid Intl (LAS)
Cheapest • Avg $365 (round-trip)
Dallas/Fort Worth (DFW)
Shortest trip • 6h 55m (one-way)
Insights
Insights
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We hope you love your trip to Santa Ana!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Knoxville to Santa Ana (TYS-SNA)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Knoxville to Santa Ana

Wed, Dec 2 - Sat, Dec 5
Delta Logo
7:00 am - 11:48 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 48m1 stop Atlanta Hartsfield-Jackson
Delta Logo
6:45 am - 5:30 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 45m1 stop Atlanta Hartsfield-Jackson
$363Delta
Mon, Nov 23 - Thu, Dec 3
Multiple Airlines Logo
1:32 pm - 5:59 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 27m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
2:15 pm - 8:25 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
27h 10m1 stop Las Vegas Harry Reid Intl
$374Multiple Airlines
Mon, Nov 23 - Thu, Dec 3
Multiple Airlines Logo
1:32 pm - 5:59 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 27m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
2:15 pm - 8:25 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
27h 10m1 stop Las Vegas Harry Reid Intl
$375Multiple Airlines
Wed, Nov 25 - Wed, Dec 2
United Airlines Logo
5:05 pm - 10:00 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 55m1 stop Denver Intl
United Airlines Logo
11:34 am - 9:57 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 23m1 stop Houston George Bush Intcntl
$383United Airlines
Wed, Nov 25 - Wed, Dec 2
United Airlines Logo
5:05 pm - 10:00 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 55m1 stop Denver Intl
United Airlines Logo
11:20 am - 11:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
9h 39m2 stops Denver Intl Washington, D.C. Dulles Intl
$388United Airlines
Wed, Nov 25 - Wed, Dec 2
American Airlines Logo
5:30 am - 10:01 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 31m1 stop Dallas/Fort Worth
American Airlines Logo
7:15 am - 6:44 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
8h 29m1 stop Charlotte Douglas
$415American Airlines
Wed, Nov 25 - Tue, Dec 1
American Airlines Logo
5:30 pm - 10:38 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 08m1 stop Dallas/Fort Worth
American Airlines Logo
1:17 pm - 11:32 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 15m1 stop Dallas/Fort Worth
$415American Airlines
Wed, Nov 25 - Wed, Dec 2
Southwest Logo
5:35 pm - 9:55 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 20m1 stop Denver Intl
Southwest Logo
7:00 am - 7:50 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
9h 50m2 stops Austin Bergstrom Nashville Intl
$433Southwest
Fri, Feb 12 - Sun, Feb 21
Southwest Logo
5:20 pm - 9:55 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 35m1 stop Denver Intl
Southwest Logo
8:00 am - 4:40 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
5h 40m1 stop Dallas Love Field
$450Southwest
Fri, Oct 23 - Sun, Oct 25
Delta Logo
6:23 pm - 10:12 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
6h 49m1 stop Atlanta Hartsfield-Jackson
Delta Logo
2:00 pm - 11:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 59m1 stop Atlanta Hartsfield-Jackson
$481Delta
Booking Insights

Price, demand and travel trends for Knoxville to Santa Ana flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Knoxville to Santa Ana with more confidence.

How much is a round-trip flight from Knoxville to Santa Ana?

Round-trip flights from Knoxville to Santa Ana start at $320. Prices are below average for this route right now, with typical round-trip fares ranging from $422 to $696. The lowest price found in the past 5 days was $320 on American Airlines.

What's the cheapest day of the week to fly from Knoxville to Santa Ana?

Thursday is the cheapest day of the week to fly from Knoxville to Santa Ana, it is 16% cheaper than the average day. Friday is the most expensive day with flight prices 16% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from Knoxville to Santa Ana?

•December is the cheapest month to fly from Knoxville to Santa Ana at $358 round-trip.
•November ($699) and January ($640) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 95% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

Find deals

Key details for Knoxville to Santa Ana flights

Low season

January

Cheapest flight

$182
Best time to beat the crowds but there is an average 16% increase in price.
Most popular time to fly with an average 9% increase in price.
Flight from Knoxville to Santa Ana

When to book flights from Knoxville to Santa Ana

Are your dates flexible? Find out the best times to travel from Knoxville to Santa Ana based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Knoxville to Santa Ana flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • What cabin classes can I book on flights from Knoxville to Santa Ana?

    Two cabin classes are available on flights from Knoxville to Santa Ana:

    • Economy Class
    • First Class

  • How long is a flight from Knoxville to Santa Ana?

    A nonstop flight from Knoxville to Santa Ana takes 0h 00m, covering 1,918 miles.

  • Do I need a passport to fly from Knoxville to Santa Ana?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • How much should I expect to pay for a Knoxville to Santa Ana flight?

    Round-trip flights from Knoxville to Santa Ana range from $422 to $696, with an average of $550 over the past 12 months. Anything below $422 counts as a good deal.

  • Have flight prices from Knoxville to Santa Ana changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $363 to $1,351. That means the highest observed fare was about 4x higher than the lowest one.

  • How are flight prices from Knoxville to Santa Ana looking right now?

    One-way fares from Knoxville to Santa Ana are currently lower than usual. Average one-way flight prices are about $229, which is 25% below the typical average for this route.

  • What car rental options are available at Santa Ana J. Wayne/Orange Cnty Airport (SNA)?

    Santa Ana J. Wayne/Orange Cnty Airport (SNA) hosts 5 major car rental companies, with daily rates starting from around $19 for economy cars. Top options include:
    • Thrifty
    • Dollar
    • Budget
    • Alamo
    • GREEN MOTION

  • Which airports can I use when flying from Knoxville to Santa Ana?

    Flights from Knoxville to Santa Ana usually depart from Knoxville McGhee Tyson (TYS) and arrive at Santa Ana J. Wayne/Orange Cnty (SNA).

  • Which airports do connecting flights from Knoxville to Santa Ana pass through?

    One-stop flights from Knoxville to Santa Ana most commonly connect through:

    • Dallas/Fort Worth (DFW) - 77% of one-stop connections
    • Denver Intl (DEN) - 9% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 8% of one-stop connections
    • Las Vegas Harry Reid Intl (LAS) - 3% of one-stop connections

    Dallas/Fort Worth (DFW) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Knoxville to Santa Ana?

    Yes. Being flexible with your travel dates can save you up to 28% on the Knoxville to Santa Ana route. Thursday is the cheapest departure day at $466 round-trip on average, while Friday is the most expensive at $640, a difference of $174. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Knoxville to Santa Ana?

    Flying via Dallas/Fort Worth (DFW) gives the shortest average 1-stop total travel time at 6h 55m, compared with 7h 14m via Denver Intl (DEN) and 7h 24m via Atlanta Hartsfield-Jackson (ATL).

  • What is the time difference between Knoxville and Santa Ana?

    Santa Ana is 3 hours behind Knoxville (Pacific Time vs Eastern Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Santa Ana?

    Some of the most popular sights in Santa Ana are Embassy Suites by Hilton Santa Ana Orange County Airport, Santa Ana Zoo and Old Orange County Courthouse. These are among the most viewed places in Santa Ana on KAYAK.

Your guide to booking Knoxville to Santa Ana flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Thursday departure instead of Friday. On this route, Thursday flights average $466 - about $174 less than Friday (27% savings) based on the last 12 months.
  • If you can choose when to travel, plan your Knoxville to Santa Ana trip for December. Fares historically average $358 round-trip in that month - typically $341 less than the most expensive month, which is November (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Santa Ana J. Wayne/Orange Cnty Airport.
    - Courtyard by Marriott Santa Ana Orange County
    - voco Orange County - Airport by IHG
    - Hotel Zessa Orange County Airport, a DoubleTree by Hilton

More options for your flight from Knoxville to Santa Ana

Complete your trip to Santa Ana with a hotel stay or car rental

Car rentals in Santa Ana
Hotels in Santa Ana
Vacations in Santa Ana