SNA - TYS

$100 Find Cheap Flights from John Wayne (Santa Ana) to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Knoxville departing on 5/18. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from John Wayne (Santa Ana) to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from John Wayne (Santa Ana) to Knoxville, as well as popular online travel agencies
Travelers love KAYAK
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Everything you should know

Cheapest round-trip
$327
Typical prices: $569-$395
Multiple Airlines
Sun 5/17Thu 5/21
SNA - TYS • 1 stop
Cheapest one-way
$100
Typical prices: $188-$422
Frontier
Mon 5/18
SNA - TYS • 1 stop
Top airlines
Cheapest • from $349 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Santa Ana and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $403 (round-trip)
Shortest trip • 6h 32m (one-way)
Insights
Insights
Insights
Insights
When to book
in advance
Our data shows that travelers who book at least 3 weeks in advance save around 13% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
Cheapest • 27% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Ana to Knoxville (SNA-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Knoxville

Sun, May 17 - Thu, May 21
Multiple Airlines Logo
8:14 pm - 10:51 pm
SNA
-
TYS
23h 37m
1 stop
Multiple Airlines Logo
1:22 pm - 12:19 pm
TYS
-
SNA
25h 57m
2 stops
$327Multiple Airlines
Sun, May 24 - Thu, May 28
Delta Logo
2:00 pm - 11:56 pm
SNA
-
TYS
6h 56m
1 stop
Delta Logo
6:36 am - 12:45 pm
TYS
-
SNA
9h 09m
1 stop
$349Delta
Wed, May 27 - Sat, May 30
American Airlines Logo
2:30 pm - 11:56 pm
SNA
-
TYS
6h 26m
1 stop
American Airlines Logo
5:36 am - 9:40 am
TYS
-
SNA
7h 04m
1 stop
$361American Airlines
Sun, May 24 - Thu, May 28
American Airlines Logo
8:45 am - 7:31 pm
SNA
-
TYS
7h 46m
1 stop
American Airlines Logo
7:10 am - 2:14 pm
TYS
-
SNA
10h 04m
1 stop
$369American Airlines
Fri, Jul 3 - Thu, Jul 9
Delta Logo
11:44 am - 9:41 pm
SNA
-
TYS
6h 57m
1 stop
Delta Logo
6:05 pm - 10:25 pm
TYS
-
SNA
7h 20m
1 stop
$403Delta
Wed, May 27 - Sat, May 30
Delta Logo
11:53 am - 9:25 pm
SNA
-
TYS
6h 32m
1 stop
Delta Logo
5:35 pm - 10:29 pm
TYS
-
SNA
7h 54m
1 stop
$404Delta
Thu, Jul 16 - Mon, Jul 20
Multiple Airlines Logo
10:19 am - 12:03 pm
SNA
-
TYS
22h 44m
2 stops
Multiple Airlines Logo
2:47 pm - 10:20 pm
TYS
-
SNA
10h 33m
1 stop
$414Multiple Airlines
Thu, Jul 16 - Mon, Jul 20
Multiple Airlines Logo
10:19 am - 7:36 pm
SNA
-
TYS
30h 17m
1 stop
Multiple Airlines Logo
2:47 pm - 10:20 pm
TYS
-
SNA
10h 33m
1 stop
$415Multiple Airlines
Tue, Jun 23 - Mon, Jun 29
Multiple Airlines Logo
7:30 am - 7:37 pm
SNA
-
TYS
33h 07m
2 stops
Multiple Airlines Logo
7:22 pm - 12:15 pm
TYS
-
SNA
19h 53m
1 stop
$420Multiple Airlines
Mon, Jul 27 - Fri, Jul 31
Multiple Airlines Logo
8:55 am - 7:36 pm
SNA
-
TYS
7h 41m
1 stop
Multiple Airlines Logo
5:31 pm - 9:26 am
TYS
-
SNA
18h 55m
2 stops
$429Multiple Airlines
Booking Insights

KAYAK's insights & trends for Santa Ana to Knoxville flights

Get data-powered insights and trends into flights from Santa Ana to Knoxville to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from Santa Ana, California to Knoxville?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from Santa Ana, California to Knoxville departing in May.

What is the cheapest month to fly from John Wayne (Santa Ana) to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from John Wayne (Santa Ana) to Knoxville is August, where tickets cost $338 (return) on average. On the other hand, the most expensive months are March and June, where the average cost of round-trip tickets is $569 and $568 respectively.

How far in advance should I book a flight from John Wayne (Santa Ana) to Knoxville?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Santa Ana to Knoxville, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from John Wayne (Santa Ana) to Knoxville, you should book around 3 weeks before departure, which saves you about 13% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 22 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$100
Best time to beat the crowds with an average 2% drop in price.
Flight from John Wayne (Santa Ana) to Knoxville

When to book flights from Santa Ana to Knoxville

Are your dates flexible? Find out the best times to travel from Santa Ana to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from John Wayne (Santa Ana) to Knoxville

  • What is the cheapest flight from John Wayne (Santa Ana) to Knoxville?

    In the last 3 days, the lowest price for a flight from John Wayne (Santa Ana) to Knoxville was $100 for a one-way ticket and $306 for a round-trip.

  • Do I need a passport to fly between John Wayne (Santa Ana) and Knoxville?

    No, a passport isn't needed to fly from John Wayne (Santa Ana) to Knoxville. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from John Wayne (Santa Ana) to Knoxville?

    On your way to Knoxville, you’ll fly out from Santa Ana J. Wayne/Orange Cnty. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from John Wayne (Santa Ana) to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from John Wayne (Santa Ana) to Knoxville?

    SkyTeam, Star Alliance, and oneworld are the airline alliances operating flights between John Wayne (Santa Ana) and Knoxville, with SkyTeam being the most commonly used for this route.

  • Which is the best airline for flights from John Wayne (Santa Ana) to Knoxville, Delta or Southwest?

    The two airlines most popular with KAYAK users for flights from John Wayne (Santa Ana) to Knoxville are Delta and Southwest. With an average price for the route of $380 and an overall rating of 7.9, Delta is the most popular choice. Southwest is also a great choice for the route, with an average price of $643 and an overall rating of 7.9.

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from John Wayne (Santa Ana) is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to John Wayne (Santa Ana) with another airline. Booking your flights between John Wayne (Santa Ana) and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from John Wayne (Santa Ana) up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 4 airlines serving from Santa Ana to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from John Wayne (Santa Ana) to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Ana to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
SouthwestOverall score based on 4305 reviews
8.0Comfort
8.6Crew
7.5Entertainment
8.1Boarding
7.0Food
Airline reviews

The entire experience from boarding to landing was amazing! The crew were very friendly. Will definitely be back.

10.0 Excellentlarry, Apr 2026
LGB - PHX
Read more Southwest reviews

The entire experience from boarding to landing was amazing! The crew were very friendly. Will definitely be back.

Delayed flight, lack of information, boarding process is a mess as is the carryon luggage causing issues when leaving the plane….just a poor experience.

Comfortable. Easy. No problems. Just wish they had gf options for snacks.

The crew was very kind and made going to Hawaii relaxing and fun to look forward to! Thank you Southwest for a pleasant flight!

Terrible. Even though there’s assigned seating now, they are still the slowest boarding airline of anyone.

It was good from LAX to Phoenix, But the connection in Phoenix to Tulsa was not that great. The staff on both flights were great. The choice of free entertainment was ok nothing to brag about. The 45 min delay because of some electrical issue wasn't great from Phoenix to Tulsa. We sat there with hardly any air, The seat I had was between windows so the side of the plane pushed in on you. My being a bigger man it then made the seating area uncomfortable. The seats on the plane had no power to connect to recharge your phone or anything. I would recommend that they should look into a slot or clamp to hold your phone to enjoy while watching the entertainment choices hands-free. Also make it possible to raise the inner seat by the window be able to raise the arm rest up to make more room for larger people to set more comfortably. I would also say other then that stop price gouging the airfare or nickel and diming everything. Not fair for people having to fly for emergencies and be paying for higher prices due to the season or holidays. Your making your money either way and the cost of flying is still going to be the same regardless if there's 100 people or 200 people.

Great flight. Good snacks and drinks. Grateful it was free. The flight from Nashville to louisville, i think her name was Tracy (not sure that's right) super awesome, nice and cheerful. She really enjoyed being at work today! She was the person who scanned the boarding pass on flight wn941. She should be recommended for a raise !

Southwest was greaat! The most expensive but the least upsetting for those we were flying to see.

Boarding was easy. The seats are small and fairly uncomfortable

I was supposed to be on a later flight. When I showed up at the gate, the woman working there was extremely helpful getting moved up to this earlier flight.

While they turned off most cabin lights to allow people to sleep, I was bothered by how bright the side lights still were. It was still quite bright for me in a window seat, when I wish I could have slept!

Generally on time departures and arrivals, clean planes, sky miles membership provides great benefits (complimentary upgrades, etc).

N Everything was perfect from boarding to assistance to baggage in Tampa

Loved the crew! Sucks that we went from 1 hour and 8 minute layover to a 3 hour layover. But weather sucks like that.

Fast, lovely scenery, great info on the Delta flight screen about landmarks we were flying over. Great landing!

Long flight but comfortable and not freezing as I have experienced on Hawaiian flights to the islands. They gave us blankets just in case. Nice touch.

I took seat 15A in anticipation of window seat, there is no window.

Flight late, the waited for a long time for “personal” to arrive at gate to dock the plane in Rochester. So annoying. This flight was expected, why aren’t personel available for the jet bridge?

My recent experience was excellent on Delta! I flew with Delta Comfort and I was really comfortable in my seat. I enjoyed the in-flight service. The flight attendants were so friendly and hospitable. I love the snack on the flight as well. This was my first time flying on Delta and I will definitely consider flying with them again.

My flight was canceled on Sunday. Rebooking took three hours. Had to pay for accommodations another night. New flight was delayed for 5 hours, all that was sent was a 12 dollar food voucher, which doesn’t tell you how to use it. Then when we landed we had to sit on the plane for an hour before we could get off.

Booked through Kayak Business, had a seat in middle and towards back due to booking rate, not comfortable.

Outstanding service, efficient & friendly crew, flight was safe, comfortable & on time

It was a red-eye, but the flight felt surprisingly quick. The seats were very comfortable, and that made resting much easier. I also want to thank the gentleman seated next to me, who graciously moved so my mom could sit beside me. We slept almost the entire way. The cabin crew was respectful in not disturbing us, while also being courteous and professional throughout. Thank you, United.

Poor communication, flight was delayed for preventable reasons. I missed my connection.

Boarding was again a "free for all". We were boarding group 4, and almost the entire plane was able to board before us. It's a shame that someone who follows the rules, gets the short end of the stick. Not fair.

It was perfect! I've never flown with United before, but I definitely will in the future

I had a cancelled flight because of technical issues going to my destination, and a delayed flight coming home. All told it wasn’t a total bust.

They delayed the flight from 9:00 to 11:55 At 11:45 they canceled the flight. I paid a premium price for the tickets with poor service

We had excellent customer service despite the chaos at George Bush airport in Houston!

My flight was canceled a few hours before boarding. I was rebooked on Copa airlines and missed an important meeting .

Left early arrived early..right amount of talking from pilots..of course had to love the biscuit and water!

Boarding gate at LAX was too crowded—two gates next to one another

Flying in the United States with the major airlines has become so underwhelming. A 2-3hr flight in most other parts of the world with the major carriers of the area comes with newer, CLEANER aircraft and significantly better in flight service in terms of both staff attitude and a actual meal service.

On time departure and early arrival. Flight attendant very nice.

The SFO Lounge crew were amazing. The bartender Faris was great. Thanks!

Was not able to do a online check-in because the American Airlines system doesn't store our visa or other passport information, allowing us to have a trouble-free check-in. We were forced to have to check-in at the counter which Changes are upgrade status given that we were not able to check in much earlier.

Good flight, seated and had a water within 5 minutes. Crew was hospitable.

Delays experienced in boarding/take off due to incoming plane delayed. However, the boarding time/depart time in the app was significantly delayed in providing these updates. Usually not updated until an hour after we should have already boarded. Poorly managed.

We left at 1030 am pacific from LA and supposed to land at 7 pm Eastern in NY. They made a detour, stopped in Philadelphia and didn’t land till 1130 PM Eastern!!! Worst flight experience with no pilot communication with no explanation as to what was going on. Everyone was very frustrated to say the least.

Flight boarded from Gate 159B, the farthest gate in the LAX Bradley Terminal. While the flight operated on time, the first class cabin attendant made no recognition of my being an Advantage Executive Platinum member.

Everything you need to know for your flight from Santa Ana to Knoxville

Information on your arrival and departure airports