SNA - TYS

$155 Find Cheap Flights from John Wayne (Santa Ana) to Knoxville - Compare and Save

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1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$299
Typical prices: $398-$610
American Airlines
Sat 12/1Sun 12/9
SNA - TYS • 1 stop
Cheapest one-way
$155
Typical prices: $209-$379
United Airlines
Sat 10/6
SNA - TYS • 2 stops
Nonstop flights
Not available
There are currently no direct flights between Santa Ana and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to book
9 weeks
in advance
Our data shows that travelers who book at least 9 weeks in advance save around 45% compared to booking last minute.
Insights
Insights
When to travel
September
Cheapest • 21% price drop
March
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Atlanta Hartsfield-Jackson (ATL)
Cheapest • Avg $466 (round-trip)
Dallas Love Field (DAL)
Shortest trip • 6h 04m (one-way)
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Insights
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Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Ana to Knoxville (SNA-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Knoxville

Tue, Dec 1 - Wed, Dec 9
American Airlines Logo
12:10 pm - 9:47 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 37m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 9:55 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 25m1 stop Dallas/Fort Worth
$299American Airlines
Wed, Dec 2 - Sat, Dec 12
Delta Logo
12:00 pm - 10:17 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 17m1 stop Atlanta Hartsfield-Jackson
Delta Logo
8:25 am - 12:41 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 16m1 stop Atlanta Hartsfield-Jackson
$299Delta
Wed, Dec 2 - Wed, Dec 9
Delta Logo
12:00 pm - 10:17 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 17m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 12:41 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
10h 01m1 stop Atlanta Hartsfield-Jackson
$299Delta
Sat, Feb 13 - Sat, Feb 20
Southwest Logo
6:45 am - 5:15 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 30m1 stop Denver Intl
Southwest Logo
4:40 pm - 8:40 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 00m1 stop Dallas Love Field
$300Southwest
Sat, Feb 13 - Mon, Feb 22
Southwest Logo
6:45 am - 5:15 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 30m1 stop Denver Intl
Southwest Logo
2:40 pm - 7:15 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 35m1 stop Denver Intl
$321Southwest
Thu, Dec 3 - Sat, Dec 5
American Airlines Logo
1:20 pm - 11:32 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 12m1 stop Dallas/Fort Worth
American Airlines Logo
5:19 pm - 10:32 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 13m1 stop Charlotte Douglas
$325American Airlines
Thu, Dec 3 - Mon, Dec 7
Multiple Airlines Logo
7:39 pm - 8:25 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
21h 46m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:15 pm - 3:03 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
20h 48m1 stop Las Vegas Harry Reid Intl
$326Multiple Airlines
Thu, Oct 29 - Tue, Nov 3
United Airlines Logo
1:09 pm - 10:32 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 23m1 stop Denver Intl
United Airlines Logo
5:05 pm - 10:00 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 55m1 stop Denver Intl
$341United Airlines
Wed, Oct 21 - Tue, Oct 27
United Airlines Logo
1:05 pm - 10:14 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 09m1 stop Denver Intl
United Airlines Logo
7:00 am - 1:51 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
9h 51m1 stop Houston George Bush Intcntl
$341United Airlines
Thu, Dec 3 - Thu, Dec 10
Multiple Airlines Logo
7:39 pm - 8:25 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
21h 46m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:05 pm - 4:41 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
22h 36m2 stops Tampa St. Petersburg Dallas/Fort Worth
$347Multiple Airlines
Booking Insights

Price, demand and travel trends for Santa Ana to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights from Santa Ana to Knoxville with more confidence.

How much is a round-trip flight from Santa Ana to Knoxville?

Round-trip flights from Santa Ana to Knoxville start at $299. Prices are below average for this route right now, with typical round-trip fares ranging from $398 to $610. The lowest price found in the past 5 days was $299 on American Airlines.

What's the cheapest day of the week to fly from Santa Ana to Knoxville?

Wednesday is the cheapest day of the week to fly from Santa Ana to Knoxville, it is 14% cheaper than the average day. Thursday is the most expensive day with flight prices 22% higher than average. Based on deals found by KAYAK users in the last 12 months.

What is the cheapest month to fly from Santa Ana to Knoxville?

•September is the cheapest month to fly from Santa Ana to Knoxville at $392 round-trip.
•June ($727) and July ($610) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 85% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

When are prices from Santa Ana to Knoxville the cheapest?

Flights from Santa Ana to Knoxville are cheapest 9 weeks before departure. Booking in this window typically costs about 45% less than the average last-minute fare (within 2 weeks of the flight), based on KAYAK data.

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Key details for Santa Ana to Knoxville flights

Low season

October

Cheapest flight

$155
Best time to beat the crowds but there is an average 11% increase in price.
Most popular time to fly with an average 15% increase in price.
Flight from Santa Ana to Knoxville

When to book flights from Santa Ana to Knoxville

Are your dates flexible? Find out the best times to travel from Santa Ana to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Santa Ana to Knoxville flight questions, answered

Find helpful route details based on KAYAK data, including flight times, airports, airlines and booking questions.

  • Which airports can I use when flying from Santa Ana to Knoxville?

    Flights from Santa Ana to Knoxville usually depart from Santa Ana J. Wayne/Orange Cnty (SNA) and arrive at Knoxville McGhee Tyson (TYS).

  • What cabin classes can I book on flights from Santa Ana to Knoxville?

    Two cabin classes are available on flights from Santa Ana to Knoxville:

    • Economy Class
    • First Class

  • Which airports do connecting flights from Santa Ana to Knoxville pass through?

    One-stop flights from Santa Ana to Knoxville most commonly connect through:

    • Dallas/Fort Worth (DFW) - 70% of one-stop connections
    • Denver Intl (DEN) - 13% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 9% of one-stop connections
    • Houston George Bush Intcntl (IAH) - 2% of one-stop connections

    Dallas/Fort Worth (DFW) handles the largest share of one-stop connections on this route.

  • Can I save money by using flexible dates for flights from Santa Ana to Knoxville?

    Yes. Being flexible with your travel dates can save you up to 30% on the Santa Ana to Knoxville route. Wednesday is the cheapest departure day at $428 round-trip on average, while Thursday is the most expensive at $607, a difference of $179. KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How expensive are last-minute Santa Ana to Knoxville flights?

    Last-minute fares on this route - booked within 2 weeks of departure - run 34% above the route average of $496. Book 9 weeks before departure for the lowest fares.

  • How long is a flight from Santa Ana to Knoxville?

    A nonstop flight from Santa Ana to Knoxville takes 0h 00m, covering 1,918 miles.

  • Do I need a passport to fly from Santa Ana to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID, or another TSA-accepted form of identification.

  • Have flight prices from Santa Ana to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $299 to $2,346. That means the highest observed fare was about 8x higher than the lowest one.

  • How are flight prices from Santa Ana to Knoxville looking right now?

    One-way fares from Santa Ana to Knoxville are currently lower than usual. Average one-way flight prices are about $234, which is 24% below the typical average for this route.

  • How much time can I save by choosing a different layover airport from Santa Ana to Knoxville?

    Flying via Dallas Love Field (DAL) gives the shortest average 1-stop total travel time at 6h 04m, compared with 6h 55m via Dallas/Fort Worth (DFW) and 7h 15m via Denver Intl (DEN).

  • What is the time difference between Santa Ana and Knoxville?

    Knoxville is 3 hours ahead of Santa Ana (Eastern Time vs Pacific Time). Plan for the time shift when scheduling connections or first-day activities.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates starting from around $33 for economy cars. Top options include:
    • Budget
    • Alamo
    • Thrifty
    • Enterprise Rent-A-Car
    • Payless

  • How much should I expect to pay for a Santa Ana to Knoxville flight?

    Round-trip flights from Santa Ana to Knoxville range from $398 to $610, with an average of $496 over the past 12 months. Anything below $398 counts as a good deal.

Your guide to booking Santa Ana to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates can be flexible, aim for a Wednesday departure instead of Thursday. On this route, Wednesday flights average $428 - about $179 less than Thursday (29% savings) based on the last 12 months.
  • For the best chance at a low fare, aim to book around 9 weeks before you fly. On this route, that window historically saves about 45% versus last-minute pricing (KAYAK booking data, last 12 months).
  • If you can choose when to travel, plan your Santa Ana to Knoxville trip for September. Fares historically average $392 round-trip in that month - typically $335 less than the most expensive month, which is June (based on the last 12 months).

More options for your flight from Santa Ana to Knoxville

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