SNA - TYS

$162 Find Cheap Flights from Santa Ana to Knoxville

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to Knoxville departing on 4/15. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Knoxville

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Ana to Knoxville, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from Santa Ana to Knoxville, as well as popular online travel agencies
Travelers love KAYAK
41,299,237 searches in the past 7 days on KAYAK

Save 23% or moreCompare multiple travel sites with one search.

Track pricesNot ready to book? Create a price alert for when prices drop.

Bundle and saveSave money when you bundle your flight + hotel.

Filter your dealsChoose cabin class, free Wi-Fi and more.

Everything you should know

Cheapest round-trip
$329
Overall average: $429
American Airlines
mar 7/28mar 8/4
SNA - TYS • 1 stop
Cheapest one-way
$162
Typical prices: $263-$705
Multiple Airlines
mer 4/15
SNA - TYS • 2 stops
Top airlines
Cheapest • from $329 (round-trip)
Best reviews • 7.9 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between Santa Ana and Knoxville. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $388 (round-trip)
Shortest trip • 6h 31m (one-way)
Insights
Insights
Insights
Insights
When to book
in advance
Our data shows that travelers who book at least 3 weeks in advance save around 9% compared to booking last minute.
Insights
Insights
Insights
Insights
When to travel
Cheapest • 24% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Knoxville!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from Santa Ana to Knoxville (SNA-TYS)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from Santa Ana to Knoxville that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Knoxville

mar, lug 28 - mar, ago 4
American Airlines Logo
12:55 pm - 11:52 pm
SNA
-
TYS
7h 57m
1 stop
American Airlines Logo
1:53 pm - 8:23 pm
TYS
-
SNA
9h 30m
1 stop
$329American Airlines
mer, apr 8 - lun, apr 13
Multiple Airlines Logo
7:30 am - 9:57 pm
SNA
-
TYS
35h 27m
2 stops
Multiple Airlines Logo
1:43 pm - 7:40 pm
TYS
-
SNA
8h 57m
1 stop
$349Multiple Airlines
mar, apr 7 - mar, apr 14
American Airlines Logo
1:23 pm - 11:56 pm
SNA
-
TYS
7h 33m
1 stop
American Airlines Logo
4:09 pm - 8:50 pm
TYS
-
SNA
7h 41m
1 stop
$351American Airlines
sab, apr 25 - mer, apr 29
United Airlines Logo
7:00 am - 7:56 pm
SNA
-
TYS
9h 56m
2 stops
United Airlines Logo
4:30 pm - 9:58 pm
TYS
-
SNA
8h 28m
1 stop
$354United Airlines
lun, apr 13 - mer, apr 15
American Airlines Logo
1:23 pm - 11:56 pm
SNA
-
TYS
7h 33m
1 stop
American Airlines Logo
6:54 pm - 10:45 pm
TYS
-
SNA
6h 51m
1 stop
$361American Airlines
mer, lug 22 - mer, lug 29
United Airlines Logo
6:45 am - 3:53 pm
SNA
-
TYS
6h 08m
1 stop
United Airlines Logo
4:56 pm - 10:01 pm
TYS
-
SNA
8h 05m
1 stop
$366United Airlines
mar, lug 28 - mar, ago 4
United Airlines Logo
10:20 am - 12:35 am
SNA
-
TYS
11h 15m
2 stops
United Airlines Logo
4:56 pm - 8:40 pm
TYS
-
SNA
6h 44m
1 stop
$370United Airlines
mer, apr 22 - lun, apr 27
Multiple Airlines Logo
7:30 am - 9:57 pm
SNA
-
TYS
35h 27m
2 stops
Multiple Airlines Logo
1:43 pm - 3:33 pm
TYS
-
SNA
28h 50m
1 stop
$378Multiple Airlines
mar, lug 28 - mar, ago 4
Southwest Logo
8:00 am - 8:20 pm
SNA
-
TYS
9h 20m
2 stops
Southwest Logo
7:00 am - 1:35 pm
TYS
-
SNA
9h 35m
2 stops
$383Southwest
mer, lug 22 - mer, lug 29
United Airlines Logo
10:20 am - 10:19 pm
SNA
-
TYS
8h 59m
1 stop
United Airlines Logo
4:56 pm - 10:01 pm
TYS
-
SNA
8h 05m
1 stop
$385United Airlines
Booking Insights

KAYAK's insights & trends for Santa Ana to Knoxville flights

Get data-powered insights and trends into flights from Santa Ana to Knoxville to help you find the cheapest flights, the best time to fly and much more.

What is the cheapest month to fly from Santa Ana to Knoxville?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from Santa Ana to Knoxville, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from Santa Ana to Knoxville is August, where tickets cost $338 (return) on average. On the other hand, the most expensive months are March and December, where the average cost of round-trip tickets is $569 and $498 respectively.

How far in advance should I book a flight from Santa Ana to Knoxville?

To calculate weekly average prices, KAYAK takes all prices for each week before departure over the last year for round-trip flights from Santa Ana to Knoxville, removes the top 0.1% to account for outliers, and then takes the average of all the values for each week.

To get a below average price on the flight from Santa Ana to Knoxville, you should book around 3 weeks before departure, which saves you about 9% compared to booking last minute. For the absolute cheapest price, our data suggests you should book 21 weeks before departure.

Good to know

Low seasonJanuary
Cheapest flight$162
Best time to beat the crowds but there is an average 1% increase in price.
Flight from John Wayne (Santa Ana) to Knoxville

When to book flights from Santa Ana to Knoxville

Are your dates flexible? Find out the best times to travel from Santa Ana to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from John Wayne (Santa Ana) to Knoxville

  • What is the cheapest flight from Santa Ana to Knoxville?

    In the last 3 days, the lowest price for a flight from Santa Ana to Knoxville was $162 for a one-way ticket and $329 for a round-trip.

  • Do I need a passport to fly between John Wayne (Santa Ana) and Knoxville?

    No, a passport isn't needed to fly from John Wayne (Santa Ana) to Knoxville. However, local authorities might ask for an official ID.

  • Which airports will I be using when flying from John Wayne (Santa Ana) to Knoxville?

    On your way to Knoxville, you’ll fly out from Santa Ana J. Wayne/Orange Cnty. You’ll be landing at Knoxville McGhee Tyson.

  • Which aircraft models fly most regularly from John Wayne (Santa Ana) to Knoxville?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from John Wayne (Santa Ana) to Knoxville?

    Star Alliance, SkyTeam, and oneworld are the airline alliances operating flights between John Wayne (Santa Ana) and Knoxville, with Star Alliance being the most commonly used for this route.

  • Which is the best airline for flights from Santa Ana to Knoxville, Delta or United Airlines?

    The two airlines most popular with KAYAK users for flights from Santa Ana to Knoxville are Delta and United Airlines. With an average price for the route of $363 and an overall rating of 7.9, Delta is the most popular choice. United Airlines is also a great choice for the route, with an average price of $450 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to Knoxville?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to Knoxville.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to Knoxville?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Knoxville from John Wayne (Santa Ana) is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to Knoxville?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Knoxville with an airline and back to John Wayne (Santa Ana) with another airline. Booking your flights between John Wayne (Santa Ana) and TYS can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to Knoxville?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Knoxville from John Wayne (Santa Ana) up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from Santa Ana to Knoxville

 
See real verified KAYAK customer reviews for airlines flying from Santa Ana to Knoxville. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from Santa Ana to Knoxville? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.9
DeltaOverall score based on 8286 reviews
7.2Food
7.8Entertainment
7.9Comfort
8.1Boarding
8.5Crew
Airline reviews

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

2.0 MediocreIsabella, Mar 2026
SJC - SLC
Read more Delta reviews

I was in first class and literally the men behind me were so aggressively loud I moved myself to economy. This has become so common on Delta - people using audio without headphones, and men on 12am / late night flights drinking and yelling to talk to each other which prevents anyone around them from resting. Pretty crazy to have to move from first to economy (poorer service, less comfort...). Wild wild. Looking into other airlines.

Same experience as the flight from Norfolk to Atlanta where people are boarded in zones that don't make sense. People behind you on the plane will get on before you and they take the luggage space on your row.

Flight was delayed by 3-hours and their fix was… complimentary pretzels.

The crew, and fellow passengers, were super gracious and kind. There seemed to be plenty of bin space even though the plane was full. It’s nice to get a glass of wine with dinner in Premiere seating, and there was a lot of food.

Everything I mentioned earlier - the airbus was more comfortable indeed and the experience was further enhanced.

Smallest leg room I've ever had on a plane.

The plane was an older model, so it wasn’t as comfortable as others. The flight attendants were not helpful during onboarding. It was a full flight so there was chaos finding space for baggage.

Awesome! On time flight, early arrival, and a complimentary upgrade!

Delta One is extraordinary. I fly business when somebody hires me. I just wonder why there is such a chasm between business class and the insanely inhumane and nonsensical coach. The seats are not large enough to fit even my tiny wife. We fly 10% of what we did because we don’t want to pay 5-10 k but for $400 it’s unbearable. It seems like the accountants took over and made stupid decisions. Screw in 20 extra seats and make it so unbearable that people fly 90% less. Just put the damn price up and put some proper chairs in. But business, yay.

Delta’s staff is unmatched. From the gate agents, to the pilots, to the flight attendants… all top of the industry.

OK, we were delayed and had to de plane and reboard.

Seats are uncomfortable. This has been a trend in the industry for decades. Trying to fit more seats on each plane to increase profits at the expense of the passenger.

The flight was delayed so we were dead tired, and after that the turbulence was horrible. I was very scared.

Staff were good. My seat was in need of repair, but for a short flight was not problematic. Usual basic snack and drink setup that you'll find on any US carrier. Over, a decent, basic flight.

Complimentary light meal would be appreciated. But great flight crew service on all legs

Flight delayed for more than 16 hrs and no effort was spent to provide an alternate

Women boarding passengers at the gate was absolutely rude and disrespectful of passengers. The flight attendant was absolutely delightful! Smiling and connected with the passengers. So happy. The seats are cramped and uncomfortable but I guess that’s just the way it is Communication regarding flight was excellent

it was a very short flight so my expectations were low.

Very disappointing given gate agent behavior. Filed a formal complaint with United.

Crew was great (professional, attentive, prompt). Snacks for 4 hrs flight is deplorable.

Delay after delay with little communication then AA lost my luggage and at airport would not assist just said scan this QR code to track your luggage and submit a claim. However QR code provided did not work so have to go back to airport

Dloght delayed by 2.5 hrs . Common theme in my last four american floghts

They are rarely on time! Very hard to plan your travels when flights or connections keep getting delayed.

My seat was assigned last row behind restrooms No legroom’s I’m very Pettit Still was not comfortable Food choice was excellent

The chicken wrap was tiny ($13 for what looked like a 1/3 of a normal wrap?) and disgusting.

Mediocre would be best description. Food bland. Seat biz class uncomfortable to sleep. Crew never dimmed lights completely in an overnight flight to Europe. Would avoid AA if possible.

Small plane, poor meal choices for first class, bad terminal and boarding experience at LAX

Arrived early picked up my bag in a few minutes- great trip - thank you

Massimo, flight attendant was very authentic, attentive - wonderful. Food/wrap was just okay.

Experience was great. The best part is the free Wi-Fi connection which helps me to work on the flight

Everything you need to know for your flight from Santa Ana to Knoxville

Information on your arrival and departure airports