SNA - TYS

$182 Find Cheap Flights from John Wayne (Santa Ana) to Knoxville - Compare and Save

1 adult
1 adult, Economy, 0 bags

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Everything you should know

Cheapest round-trip
$287
Typical prices: $431-$713
Multiple Airlines
Mon 12/3Fri 12/7
SNA - TYS • 1 stop
Cheapest one-way
$182
Typical prices: $218-$383
United Airlines
Sat 12/1
SNA - TYS • 1 stop
Nonstop flights
Not available
There are currently no direct flights between Santa Ana and Knoxville. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to book
18 weeks
in advance
Our data shows that travelers who book at least 18 weeks in advance save around 51% compared to booking last minute.
Insights
Insights
When to travel
January
Cheapest • 29% price drop
March
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Las Vegas Harry Reid Intl (LAS)
Cheapest • Avg $380 (round-trip)
Dallas Love Field (DAL)
Shortest trip • 6h 04m (one-way)
Insights
Insights
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Flight Deals
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Flight Deals

Cheap Flights from Santa Ana to Knoxville (SNA-TYS)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from Santa Ana to Knoxville

Thu, Dec 3 - Mon, Dec 7
Multiple Airlines Logo
3:39 pm - 8:25 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
25h 46m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
8:00 am - 6:06 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
13h 06m2 stops Austin Bergstrom Las Vegas Harry Reid Intl
$287Multiple Airlines
Thu, Dec 3 - Mon, Dec 7
Multiple Airlines Logo
3:39 pm - 8:25 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
25h 46m1 stop Las Vegas Harry Reid Intl
Multiple Airlines Logo
9:15 pm - 3:03 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
20h 48m1 stop Las Vegas Harry Reid Intl
$321Multiple Airlines
Fri, Dec 11 - Tue, Dec 15
American Airlines Logo
6:45 am - 4:39 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 54m1 stop Dallas/Fort Worth
American Airlines Logo
5:30 am - 12:30 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
10h 00m1 stop Dallas/Fort Worth
$363American Airlines
Sat, Dec 5 - Sat, Dec 12
American Airlines Logo
7:15 am - 6:53 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
8h 38m1 stop Charlotte Douglas
American Airlines Logo
5:30 am - 12:30 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
10h 00m1 stop Dallas/Fort Worth
$363American Airlines
Mon, Jan 11 - Thu, Jan 14
Delta Logo
2:40 pm - 11:58 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 18m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:15 am - 11:20 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
9h 05m1 stop Atlanta Hartsfield-Jackson
$363Delta
Fri, Dec 11 - Tue, Dec 15
United Airlines Logo
11:20 am - 11:59 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
9h 39m2 stops Denver Intl Washington, D.C. Dulles Intl
United Airlines Logo
1:55 pm - 6:52 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 57m1 stop Chicago O'Hare Intl
$368United Airlines
Fri, Dec 11 - Tue, Dec 15
Southwest Logo
8:15 am - 8:35 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
9h 20m2 stops San Jose Nashville Intl
Southwest Logo
7:05 am - 2:00 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
9h 55m2 stops Nashville Intl Denver Intl
$373Southwest
Sat, Dec 5 - Sat, Dec 12
Southwest Logo
7:40 pm - 3:00 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
16h 20m2 stops Phoenix Sky Harbor Intl Dallas Love Field
Southwest Logo
7:10 am - 12:45 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 35m2 stops Nashville Intl Phoenix Sky Harbor Intl
$406Southwest
Tue, Dec 1 - Mon, Dec 7
United Airlines Logo
11:34 am - 9:57 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
7h 23m1 stop Houston George Bush Intcntl
United Airlines Logo
5:00 pm - 9:45 pmTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
7h 45m1 stop Houston George Bush Intcntl
$410United Airlines
Mon, Feb 8 - Thu, Feb 11
Delta Logo
2:40 pm - 11:58 pmSNA  Santa Ana J. Wayne/Orange Cnty-TYS Knoxville McGhee Tyson
6h 18m1 stop Atlanta Hartsfield-Jackson
Delta Logo
5:40 am - 11:18 amTYS  Knoxville McGhee Tyson-SNA Santa Ana J. Wayne/Orange Cnty
8h 38m1 stop Atlanta Hartsfield-Jackson
$481Delta
Booking Insights

Price, demand and travel trends for Santa Ana to Knoxville flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What's the cheapest day of the week to fly from Santa Ana to Knoxville?

Based on deals KAYAK users found in the last 12 months, Wednesday is the cheapest day of the week to fly from Santa Ana to Knoxville. It’s 19% cheaper than the average day, while Monday is the most expensive, with prices 42% higher.

What’s the cheapest month to fly from Santa Ana to Knoxville?

•January is the cheapest month to fly from Santa Ana to Knoxville at $395 round-trip.
•November ($748) and June ($727) are the most expensive months.
•The price difference between flying in the cheapest and most expensive months is 89% on average.
This is based on KAYAK aggregated and averaged internal data over the past 12 months.

When are flights from Santa Ana to Knoxville the cheapest?

Flights from Santa Ana to Knoxville are cheapest 18 weeks before departure. Booking in this window typically costs about 51% less than the average last-minute fare (within 2 weeks of the flight), based on KAYAK data.

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Key details for Santa Ana to Knoxville flights

Low season

January

Cheapest flight

$182
Beat the crowds with an average 20% drop in travelers.
The most popular month to fly with an average 24% increase in travelers.
One-way flight from Santa Ana to Knoxville

When to book flights from Santa Ana to Knoxville

Are your dates flexible? Find out the best times to travel from Santa Ana to Knoxville based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your Santa Ana to Knoxville flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from Santa Ana to Knoxville?

    Two cabin classes are available on flights from Santa Ana to Knoxville:

    • Economy Class
    • First Class

  • How long is a flight from Santa Ana to Knoxville?

    A nonstop flight from Santa Ana to Knoxville takes 00m, covering 1,918 miles.

  • Do I need a passport to fly from Santa Ana to Knoxville?

    No, a passport is not required for this domestic route, but you will need a real ID-compliant driver's license, a state ID or another TSA-accepted form of identification.

  • How much should I expect to pay for a Santa Ana to Knoxville flight?

    Round-trip flights from Santa Ana to Knoxville range from $431 to $713, with an average of $557 over the past 12 months. Anything below $431 counts as a good deal.

  • How expensive are last-minute Santa Ana to Knoxville flights?

    Last-minute fares on this route (booked within two weeks of departure) run 44% above the $557 route average. Book 18 weeks before departure for the lowest fares.

  • Have flight prices from Santa Ana to Knoxville changed much recently?

    Yes. Based on fares seen in the past 5 days, round-trip prices on this route showed a wide range, from about $287 to $1,228. That means the highest observed fare was about 4x higher than the lowest one.

  • How are flight prices from Santa Ana to Knoxville looking right now?

    One-way fares from Santa Ana to Knoxville are currently lower than usual. Average one-way flight prices are about $226, which is 29% below the typical average for this route.

  • What car rental options are available at Knoxville McGhee Tyson Airport (TYS)?

    Knoxville McGhee Tyson Airport (TYS) hosts 5 major car rental companies, with daily rates averaging $80 for economy cars. Top options include:

    • Budget
    • Alamo
    • Enterprise Rent-A-Car
    • Thrifty
    • Avis

  • Which airports can I use when flying from Santa Ana to Knoxville?

    Flights from Santa Ana to Knoxville usually depart from Santa Ana J. Wayne/Orange Cnty (SNA) and arrive at Knoxville McGhee Tyson (TYS).

  • Which airports do connecting flights from Santa Ana to Knoxville pass through?

    One-stop flights from Santa Ana to Knoxville most commonly connect through:

    • Dallas/Fort Worth (DFW) - 63% of one-stop connections
    • Denver Intl (DEN) - 22% of one-stop connections
    • Atlanta Hartsfield-Jackson (ATL) - 10% of one-stop connections
    • Houston George Bush Intcntl (IAH) - 2% of one-stop connections

  • Can I save money by using flexible dates for flights from Santa Ana to Knoxville?

    Yes. Flexible dates can save you up to 43% on flights from Santa Ana to Knoxville. Wednesday is the cheapest departure day at $454 round-trip on average, while Monday is the most expensive at $796, a difference of $342.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from Santa Ana to Knoxville?

    Flying via Dallas Love Field (DAL) gives the shortest average 1-stop total travel time at 6h 04m, compared with 6h 53m via Dallas/Fort Worth (DFW) and 7h 03m via Denver Intl (DEN).

  • What is the time difference between Santa Ana and Knoxville?

    Knoxville is 3 hours ahead of Santa Ana (Eastern Time vs Pacific Time). Plan for the time shift when scheduling connections or first-day activities.

Your guide to booking Santa Ana to Knoxville flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Wednesday departure and avoid flying on Monday. On this route, Wednesday flights average $454, about $342 less than Monday fares (43% savings) based on the last 12 months.
  • For the best chance at a low fare, aim to book around 18 weeks before you fly. On this route, that window historically saves about 51% versus last-minute pricing (KAYAK booking data, last 12 months).
  • If you can choose when to travel, plan your Santa Ana to Knoxville trip for January. Fares historically average $395 round-trip in that month - typically $353 less than the most expensive month, which is November (based on the last 12 months).

More options for your flight from Santa Ana to Knoxville

Complete your trip to Knoxville with a hotel stay or car rental

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