STL - SCL

$461 Find Cheap Flights from St. Louis to Santiago - Compare and Save

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Everything you should know

Cheapest round-trip
$718
Typical prices: $883-$1,267
Multiple Airlines
Tue 11/27Tue 12/4
STL - SCL • 2 stops
Cheapest one-way
$461
Typical prices: $533-$753
Multiple Airlines
Fri 12/28
STL - SCL • 3 stops
Nonstop flights
Not available
There are currently no direct flights between St. Louis and Santiago. You'll need to take a connecting flight to reach the destination.
Insights
Insights
When to travel
March
Cheapest • 32% price drop
February
Most popular
Good to know
+1
Good to know
+1
Top layover airports
Houston George Bush Intcntl (IAH)
Cheapest • Avg $1,058 (round-trip)
Dallas/Fort Worth (DFW)
Shortest trip • 13h 46m (one-way)
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Insights
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Flight Deals

Cheap Flights from St. Louis to Santiago (STL-SCL)

 
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Santiago

Wed, Dec 23 - Mon, Dec 28
LATAM Airlines Logo
6:00 am - 5:55 amSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
20h 55m2 stops Atlanta Hartsfield-Jackson Miami
LATAM Airlines Logo
11:00 pm - 11:52 amSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
15h 52m1 stop Atlanta Hartsfield-Jackson
$962LATAM Airlines
Wed, Dec 23 - Mon, Dec 28
LATAM Airlines Logo
9:52 am - 3:00 pmSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
26h 08m3 stops Atlanta Hartsfield-Jackson Miami Buenos Aires Ministro Pistarini
LATAM Airlines Logo
8:25 pm - 9:07 amSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
15h 42m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson
$962LATAM Airlines
Wed, Dec 23 - Mon, Dec 28
LATAM Airlines Logo
6:00 am - 5:55 amSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
20h 55m2 stops Atlanta Hartsfield-Jackson Miami
LATAM Airlines Logo
5:55 pm - 9:07 amSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
18h 12m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson
$962LATAM Airlines
Tue, Dec 1 - Thu, Dec 10
Multiple Airlines Logo
4:05 pm - 6:38 amSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
35h 33m2 stops Toronto Pearson Intl Punta Cana
Multiple Airlines Logo
10:00 am - 11:17 amSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
28h 17m3 stops Punta Cana Newark Atlanta Hartsfield-Jackson
$1,084Multiple Airlines
Tue, Dec 1 - Thu, Dec 10
Multiple Airlines Logo
4:05 pm - 6:38 amSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
35h 33m3 stops Toronto Pearson Intl Montreal Pierre Elliott Trudeau Intl Punta Cana
Multiple Airlines Logo
10:00 am - 11:17 amSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
28h 17m3 stops Punta Cana Newark Atlanta Hartsfield-Jackson
$1,087Multiple Airlines
Wed, Dec 30 - Thu, Jan 14
Delta Logo
12:37 pm - 7:40 amSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
16h 03m1 stop Atlanta Hartsfield-Jackson
Delta Logo
9:50 pm - 9:17 amSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
14h 27m1 stop Atlanta Hartsfield-Jackson
$1,116Delta
Mon, Feb 15 - Tue, Mar 2
Delta Logo
3:40 pm - 3:00 pmSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
20h 20m2 stops Atlanta Hartsfield-Jackson Lima J Chavez Intl
Delta Logo
8:25 pm - 2:43 pmSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
21h 18m2 stops Lima J Chavez Intl Atlanta Hartsfield-Jackson
$1,116Delta
Fri, Apr 9 - Fri, Apr 16
American Airlines Logo
10:00 am - 7:05 amSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
20h 05m1 stop Miami
American Airlines Logo
8:35 pm - 9:20 amSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
13h 45m1 stop Miami
$1,116American Airlines
Mon, Feb 15 - Tue, Mar 2
United Airlines Logo
10:05 am - 8:50 amSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
19h 45m1 stop Houston George Bush Intcntl
United Airlines Logo
10:45 pm - 4:46 pmSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
21h 01m1 stop Houston George Bush Intcntl
$1,116United Airlines
Fri, Apr 9 - Fri, Apr 16
American Airlines Logo
9:37 am - 7:05 amSTL  Lambert-St Louis-SCL Santiago Arturo Merino Benitez
20h 28m2 stops Dallas/Fort Worth Miami
American Airlines Logo
8:35 pm - 3:06 pmSCL  Santiago Arturo Merino Benitez-STL Lambert-St Louis
19h 31m2 stops Miami Dallas/Fort Worth
$1,120American Airlines
Booking Insights

Price, demand and travel trends for St. Louis to Santiago flights

Use KAYAK data on prices, travel dates, airlines and seasonal trends to compare options and book flights with more confidence.

What's the cheapest day of the week to fly from St. Louis to Santiago?

Based on deals KAYAK users found in the last 12 months, Wednesday is the cheapest day of the week to fly from St. Louis to Santiago. It’s 20% cheaper than the average day, while Sunday is the most expensive, with prices 25% higher.

Find deals

Key details for St. Louis to Santiago flights

Low season

October

Cheapest flight

$461
Beat the crowds with an average 67% drop in travelers.
The most popular month to fly with an average 33% increase in travelers.
One-way flight from St. Louis to Santiago

When to book flights from St. Louis to Santiago

Are your dates flexible? Find out the best times to travel from St. Louis to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price

Your St. Louis to Santiago flight questions, answered

Find helpful answers about this route, including flight times, airports, airlines and booking tips.

  • What cabin classes can I book on flights from St. Louis to Santiago?

    Four cabin classes are available on flights from St. Louis to Santiago:

    • Economy Class
    • Premium Economy Class
    • Business Class
    • First Class

    Prices vary by airline.

  • How long is a flight from St. Louis to Santiago?

    A nonstop flight from St. Louis to Santiago takes 00m, covering 5,137 miles.

  • Do I need a passport to fly from St. Louis to Santiago?

    Yes, a valid passport is required for this international route. Many destinations require at least six months of validity beyond your travel dates. Check your passport expiry well before booking.

  • How much should I expect to pay for a St. Louis to Santiago flight?

    Round-trip flights from St. Louis to Santiago range from $883 to $1,267, with an average of $1,112 over the past 12 months. Anything below $883 counts as a good deal.

  • How are flight prices from St. Louis to Santiago looking right now?

    One-way fares from St. Louis to Santiago are currently lower than usual. Average one-way flight prices are about $576, which is 14% below the typical average for this route.

  • What car rental options are available at Santiago Arturo Merino Benitez Airport (SCL)?

    Santiago Arturo Merino Benitez Airport (SCL) hosts 5 major car rental companies, with daily rates averaging $36 for economy cars. Top options include:

    • Lucano
    • United Rent-A-Car
    • Rosselot
    • FlexWays
    • Alamo

  • Which airports can I use when flying from St. Louis to Santiago?

    Flights from St. Louis to Santiago usually depart from Lambert-St Louis (STL) and arrive at Santiago Arturo Merino Benitez (SCL).

  • Which airports do connecting flights from St. Louis to Santiago pass through?

    One-stop flights from St. Louis to Santiago most commonly connect through:

    • Atlanta Hartsfield-Jackson (ATL) - 65% of one-stop connections
    • Houston George Bush Intcntl (IAH) - 14% of one-stop connections
    • Miami (MIA) - 12% of one-stop connections
    • Dallas/Fort Worth (DFW) - 8% of one-stop connections

  • Can I save money by using flexible dates for flights from St. Louis to Santiago?

    Yes. Flexible dates can save you up to 36% on flights from St. Louis to Santiago. Wednesday is the cheapest departure day at $894 round-trip on average, while Sunday is the most expensive at $1,395, a difference of $501.

    KAYAK's flexible dates feature shows options up to 3 days before and after your selected dates, making it easier to compare nearby fares.

  • How much time can I save by choosing a different layover airport from St. Louis to Santiago?

    Flying via Dallas/Fort Worth (DFW) gives the shortest average 1-stop total travel time at 13h 46m, compared with 13h 51m via Atlanta Hartsfield-Jackson (ATL) and 14h 02m via Houston George Bush Intcntl (IAH).

  • What is the time difference between St. Louis and Santiago?

    Santiago is 2 hours ahead of St. Louis (Chile Time vs Central Time). Plan for the time shift when scheduling connections or first-day activities.

  • What popular places can I visit in Santiago?

    Some of the most popular sights in Santiago are Estadio Nacional Julio Martinez Pradanos, Espacio Riesco Convention and Exhibition Center and Costanera Center. These are among the most viewed places in Santiago on KAYAK.

Your guide to booking St. Louis to Santiago flights

Get tips on when to book, when to fly and what to know before your trip.
  • If your dates are flexible, aim for a Wednesday departure and avoid flying on Sunday. On this route, Wednesday flights average $894, about $501 less than Sunday fares (36% savings) based on the last 12 months.
  • If you can choose when to travel, plan your St. Louis to Santiago trip for March. Fares historically average $755 round-trip in that month - typically $850 less than the most expensive month, which is June (based on the last 12 months).
  • If you're arriving late at night and need somewhere to stay, check out these hotels close to Santiago Arturo Merino Benitez Airport.

    • Holiday Inn Santiago - Airport Terminal By IHG

More options for your flight from St. Louis to Santiago

Complete your trip to Santiago with a hotel stay or car rental

Car rentals in Santiago
Hotels in Santiago
Vacations in Santiago