STL - SCL

$479 Find Cheap Flights from St. Louis to Santiago

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from St. Louis to Santiago departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
1 adult, Economy, 0 bags

KAYAK searches hundreds of travel sites at once for deals on flights to Santiago

 
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Santiago, as well as popular online travel agencies
These are the airlines KAYAK users have selected most often from within our search results in flight searches from St. Louis to Santiago, as well as popular online travel agencies
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41,299,237 searches in the past 7 days on KAYAK

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Everything you should know

Cheapest round-trip
$947
Typical prices: $843-$1,195
American Airlines
Tue 9/1Sun 9/6
STL - SCL • 1 stop
Cheapest one-way
$479
Typical prices: $533-$687
Multiple Airlines
Fri 7/10
STL - SCL • 3 stops
Top airlines
Cheapest • from $947 (round-trip)
Best reviews • 7.8 score
Airline reviews
Airline reviews
+1
+1
Airline reviews
Airline reviews
+1
Nonstop flights
Not available
There are currently no direct flights between St. Louis and Santiago. You'll need at least 1 connection.
Insights
Insights
Insights
Insights
Top layover airports
Cheapest • Avg $1,082 (round-trip)
Shortest trip • 13h 08m (one-way)
Insights
Insights
Insights
Insights
When to travel
Cheapest • 29% price drop
Most popular
Good to know
Good to know
+1
+1
Good to know
Good to know
+1
Start a new search
KAYAK searches 100s of sites at once to find you the best travel deals.
We hope you love your trip to Santiago!
Flight Deals
Booking Insights
Flight Deals

Cheap Flights from St. Louis to Santiago (STL-SCL)

 
Here are some of the best deals found on KAYAK recently from the most popular airlines for round-trip flights from St. Louis to Santiago that are departing in the next months. While these flights were available on KAYAK in the last 72 hours, prices and availability are subject to change and deals may expire.
Discover the best prices for you by selecting your travel dates on KAYAK.

Recent round-trip flight deals from St. Louis to Santiago

Tue, Sep 1 - Sun, Sep 6
American Airlines Logo
11:35 am - 6:25 am
STL
-
SCL
17h 50m
1 stop
American Airlines Logo
9:50 pm - 10:45 am
SCL
-
STL
14h 55m
1 stop
$947American Airlines
Tue, Sep 1 - Sun, Sep 6
American Airlines Logo
12:45 pm - 6:25 am
STL
-
SCL
16h 40m
2 stops
American Airlines Logo
9:50 pm - 10:45 am
SCL
-
STL
14h 55m
1 stop
$952American Airlines
Wed, Sep 2 - Mon, Sep 7
LATAM Airlines Logo
6:00 am - 10:49 am
STL
-
SCL
27h 49m
3 stops
LATAM Airlines Logo
4:30 pm - 11:42 pm
SCL
-
STL
33h 12m
2 stops
$957LATAM Airlines
Tue, Sep 1 - Sun, Sep 6
LATAM Airlines Logo
12:52 pm - 1:25 pm
STL
-
SCL
23h 33m
3 stops
LATAM Airlines Logo
11:05 pm - 9:34 am
SCL
-
STL
36h 29m
2 stops
$962LATAM Airlines
Tue, Sep 1 - Sun, Sep 6
LATAM Airlines Logo
12:52 pm - 1:25 pm
STL
-
SCL
23h 33m
3 stops
LATAM Airlines Logo
11:05 pm - 9:34 am
SCL
-
STL
36h 29m
2 stops
$972LATAM Airlines
Tue, Dec 1 - Mon, Dec 14
LATAM Airlines Logo
6:00 am - 7:40 am
STL
-
SCL
22h 40m
1 stop
LATAM Airlines Logo
12:55 am - 5:06 pm
SCL
-
STL
19h 11m
1 stop
$978LATAM Airlines
Mon, Jul 13 - Sun, Jul 19
LATAM Airlines Logo
10:51 am - 7:15 am
STL
-
SCL
19h 24m
1 stop
LATAM Airlines Logo
11:05 pm - 5:53 pm
SCL
-
STL
19h 48m
2 stops
$983LATAM Airlines
Mon, Jul 13 - Sun, Jul 19
Delta Logo
1:22 pm - 7:15 am
STL
-
SCL
16h 53m
1 stop
Delta Logo
8:40 pm - 12:17 pm
SCL
-
STL
16h 37m
1 stop
$987Delta
Tue, Jul 14 - Tue, Jul 21
LATAM Airlines Logo
1:22 pm - 1:25 pm
STL
-
SCL
23h 03m
3 stops
LATAM Airlines Logo
8:40 pm - 9:43 am
SCL
-
STL
14h 03m
1 stop
$988LATAM Airlines
Mon, Jul 13 - Sun, Jul 19
LATAM Airlines Logo
6:58 pm - 9:45 pm
STL
-
SCL
25h 47m
3 stops
LATAM Airlines Logo
11:05 pm - 5:53 pm
SCL
-
STL
19h 48m
2 stops
$993LATAM Airlines
Booking Insights

KAYAK's insights & trends for St. Louis to Santiago flights

Get data-powered insights and trends into flights from St. Louis to Santiago to help you find the cheapest flights, the best time to fly and much more.

How much is a round-trip flight from St. Louis to Santiago?

This analysis is based on the cheapest round-trip price found on KAYAK in the last 12 months by searching for a flight from St. Louis to Santiago departing in September.

What is the cheapest month to fly from St. Louis to Santiago?

To calculate monthly average prices, KAYAK takes all prices for each month over the last year for round-trip flights from St. Louis to Santiago, removes the top 0.1% to account for outliers, and then takes the median of all values for each month.

The cheapest month for flights from St. Louis to Santiago is July, where tickets cost $811 (return) on average. On the other hand, the most expensive months are January and June, where the average cost of round-trip tickets is $1,948 and $1,605 respectively.

Good to know

Low seasonApril
Cheapest flight$479
Best time to beat the crowds with an average 12% drop in price.
Most popular time to fly and prices are also 18% lower on average.
Flight from St. Louis to Santiago

When to book flights from St. Louis to Santiago

Are your dates flexible? Find out the best times to travel from St. Louis to Santiago based on our flight data from the last year. Discover the cheapest month and even day to fly.
Estimated round-trip price
KAYAK looks at all historical flight data for each date to provide a predicted price for one-way trips or round-trips with a duration up to 40 days. While we try to provide actual minimum prices for each date, some prices are predictions and actual prices may differ.

FAQs for booking flights from St. Louis to Santiago

  • What is the cheapest flight from St. Louis to Santiago?

    In the last 5 days, the lowest price for a flight from St. Louis to Santiago was $479 for a one-way ticket and $947 for a round-trip.

  • Do I need a passport to fly between St. Louis and Santiago?

    Yes, you'll most likely have to show a valid passport before boarding the plane in St. Louis and on arrival in Santiago.

  • Which aircraft models fly most regularly from St. Louis to Santiago?

    We unfortunately don’t have that data for this specific route.

  • Which airline alliances offer flights from St. Louis to Santiago?

    oneworld, and SkyTeam are the airline alliances operating flights between St. Louis and Santiago, with oneworld being the most commonly used for this route.

  • Which is the best airline for flights from St. Louis to Santiago, Delta or LATAM Airlines?

    The two airlines most popular with KAYAK users for flights from St. Louis to Santiago are Delta and LATAM Airlines. With an average price for the route of $1,112 and an overall rating of 7.8, Delta is the most popular choice. LATAM Airlines is also a great choice for the route, with an average price of $1,013 and an overall rating of 7.4.

  • How does KAYAK find such low prices on flights from St. Louis to Santiago?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from St. Louis to Santiago.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from St. Louis to Santiago?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to Santiago from St. Louis is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from St. Louis to Santiago?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to Santiago with an airline and back to St. Louis with another airline. Booking your flights between St. Louis and SCL can sometimes prove cheaper using this method.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from St. Louis to Santiago?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to Santiago from St. Louis up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

Reviews of the top 3 airlines serving from St. Louis to Santiago

 
See real verified KAYAK customer reviews for airlines flying from St. Louis to Santiago. Airline scores are aggregated from all reviews left by passengers on KAYAK after flying with an airline. KAYAK doesn’t show reviews that are older than 5 years. Learn how KAYAK collects reviews.
Need help choosing which airline to fly with from St. Louis to Santiago? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
7.8
DeltaOverall score based on 8420 reviews
7.8Entertainment
7.8Comfort
7.2Food
8.5Crew
8.1Boarding
Airline reviews

Flight got canceled 4 times, missed my connecting flight due to delays, have to wait to go home tomorrow

2.0 MediocreChelsea, Jun 2026
DAL - ATL
Read more Delta reviews

Flight got canceled 4 times, missed my connecting flight due to delays, have to wait to go home tomorrow

Third flight in two months where the crew was not there. Comfort seating does not guarantee overhead bin space. Passengers with children are allowed on the plane first - if you are flying to and from Orlando, this means half the plane has boarded before you get on. And somehow all the bin space is taken up. 3 out of 5 flights have had issues with equipment or procedure. Some of these instances caused the flight to be delayed because of a "nuisance" light. One time it was a bag that had been brought on board but did not belong to anyone so we had to return to the gate. Last night we were told the "AC" on the plane doesn't work well and we're 10th for take off- because the crew was late - and that it will get cool when we're in the air. Not sure if this is usual, but I didn't think flight crew could jump seat in first class. Movie and TV selection has not been refreshed for several months- flying one to two round trips each month easily exhausts the list of content.

Great experience nice pilot very soft and easy landing and take off

We sat on the runway for over an hour before departure. That was unwelcome.

Horrible. Faucet in sink not working, wifi not working. Didn’t bring food or snacks

Flight was delayed before take off and at landing. Baggage took 20 minutes. Flight crew would not serve full soft drink and had to ask multiple times before receiving water.

From checking to boarding, it was a seamless experience. The service agents were so helpful. The flight crew was so pleasant.

Gate agent showed up 20 minutes before boarding and was not at all friendly. Had to take this flight due to the one on the day before being cancelled and any later options were already full with long standby lists. Despite having paid for Delta Comfort seats, Delta did not allow me (or anyone) to choose their seat. The agent assigned them for everyone just prior to boarding. Self seat selection was allowed on the original flight. Flight staff was great - very friendly.

Flight attendants were great. Cheerful, upbeat and friendly. Jet, in particular, was fantastic.

I have Precheck. Flew HPN to DEN and return this past weekend. Delta didn't attach my Precheck number to this trip. So it was waiting in general line especially in Denver. Unavailable.

Honestly first time flying with delta and it was pretty good. All the process very smooth and crew was always nice and attentive.

Deleted flight made me loose my connection flight now stuck in Atlanta for a day

Apart of Sky miles delta. And they go everywhere in Brazil

Latam wouldn’t tell me how much checked luggage would until I was at the airport and they charged me the highest price possible. Besides that, it was okay.

We traveled with two young children, and it was not possible for our family to be seated together. No one offered help or assistance to organize seating so we could sit with our kids. In the end, we managed to find two seats in Economy so I could at least sit with one of them, even though I had originally paid for Comfort+. In summary, I had to downgrade my seat just to be able to sit with one of my children, which was very disappointing

I booked a flight through Kayak to Brazil I have traveled to Brazil several times before Kayak Delta or LATAM never mentioned during the booking or in the pre flight process that the visa requirements to visit Brazil have changed earlier this year. I was unaware of this change and as such never got a visa and was unable to fly from JFK to Sao Paulo Add to this that Delta allowed me to fly from Boston to JFK which they should not have as I didn’t have a visa. It has been a terrible experience and a huge loss of money

Wish the seats were a little more comfortable.. it was a 6 hrs nonstop trip. But the crew was courteous and w a smile

The assistance we received and the flight itself was wonderful. We will fly with LATAM airlines again, in the future.

Latam may be the worst airline in the world, far worse than even the lowest of low cost airlines in the USA. I wasted hours trying to PAY THEM TO CHECK A BAG! Then they misled me at the terminal, sent me through the wrong security line, the list goes on and on... Just absolutely terrible in every way. Avoid at all costs.

Check in -- in business took over 30 mins as there was only one attendant. Boarding was also a mess. The seat was too narrow and was not working properly. Food was very bad and the entertainment very poor. Crew was very polite and helpful, in fairness.

Flight cancelled. Twice. And no communication. No gate agent. Went past boarding time and had to go and see email from AA. Airport communication was bad

I love the e fact that the staff communicated swiftly when my flight was delayed and gate number changed

It was awful. The communication between corporate and the crew on the ground left more to be desired. The crew even said that Corporate was waiting on answers because they themselves didn't know. Every hour, there was a new excuse. I also understood that passengers were angry, but the crew should have done a better job at crowd control. There was a racial exchange between passengers that could've been avoided has the crew acted sooner.

Delayed and horrible communication and sat on flight for an hour before taking off

Flight was delayed three times and we had an international connecting flight which we would’ve missed but AA manage to find us a flight that allowed us to catch and we made our international flight. However, due to the flight change, I’m in Amman, Jordan missing all 4 bags. It’s been a nightmare. Been waiting since June 17 and today is June 20th. Still without luggage. Customer service wait times are two hours and I get disconnected while waiting. I’ll update when/if my luggage arrives. Every day is costing money in a hotel in Amman. I can’t continue my trip to Palestine until the luggage arrives. Then, I will be updating my review.

They did not offer coffee on a 7am flight…awful!!

Plane temperature was so hot that everyone on the plane was sweating. Departure gates changed 3 times in the hour before the flight. Internet service was so poor in the terminal that updates weren't always being received.

We had a mechanical delay which made us 90 minutes late (9:30 PM) then land and put into the penalty box because a plane was in our gate? What the hell! We should get priority.Damn American.

Check in for 5am flight at RDU was hampered by American check in counters being seriously understaffed , was told even supervisor called out. Took so long in line for special services check in that we missed our 5am departure even after arriving at 3:30am. Had to be rescheduled to later flight from Charlotte to St Thomas.

Delayed flight due to maintenance and I have had multiple delayed flights due to maintenance in the last month plus

Everything you need to know for your flight from St. Louis to Santiago

Information on your arrival and departure airports